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Every movement of your body involves
your joints. Joints are protected and supported by cartilage, a dense,
shock absorbing connective tissue; and protective synovial fluid that
lubricates joint movement.
Stress on joints can damage cartilage
and trigger the natural inflammatory response, leading to swelling and
significant discomfort. The natural inflammatory response is the body’s
attempt to minimize the adverse affects of stress and trauma. This
mechanism is highly effective, but often excessive. An overabundance of
synovial fluid in joints results in swelling, discomfort and limited
movement. Supplements to relieve joint discomfort should therefore focus
on protecting and building cartilage and maintaining normal synovial fluid
levels.
Sulfur compounds, such as those found in
Nature’s Life MSM Tri-Sulfate Joint Ease™, are critical for
maintaining and protecting normal cartilage structure and inhibiting the
natural inflammatory response with few, if any, side effects.* Drugs that
reduce inflammation are effective, but even the relatively
"safe" ones like aspirin can induce gastritis or ulcers.
Nature’s Life MSM Tri-Sulfate Joint
Ease™ Supplement
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Contains MSM, chondroitin sulfate
and glucosamine sulfate
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Reduces discomfort and tenderness in
joints*
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Helps maintain normal cartilage
growth and function*
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Attracts cushioning fluids to the
cartilage matrix*
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Helps slow the action of degrading
enzymes in joints*
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Naturally occurring source of
dietary sulfur.
Sulfur
Sulfur is the eighth most abundant
element in all living organisms and is found in especially high
concentrations in the connective tissues of joints, where it is essential
for maintaining normal function. Supplementing the body’s sulfur intake
can have significant potential for relieving joint discomfort.*1,2
MSM
MSM (Methylsulfonyl Methane) is a
naturally occurring form of sulfur.3 MSM’s effectiveness is thought to
be a result of its action as a sulfur donor to repair damaged connective
tissues.*4 An odorless, white crystalline substance, MSM is an oxidative
product of its parent compound dimethyl sulfoxide (DMSO).4,5 Several
well-established studies have shown conclusively that DMSO is highly
effective in relieving joint discomfort and inhibiting the natural
inflammatory response.*6,7,8,9 MSM appears to provide the same benefits as
DMSO, yet MSM is retained in the body longer and does not produce sulfur’s
strong, unpleasant odor.*6
Glucosamine Sulfate
Glucosamine sulfate is a
mucopolysaccharide found in cartilage and synovial fluid. A
mucopolysaccharide is a compound of glucose (a sugar) and glutamine (an
amino acid). Glucosamine bonds to water to create pockets of moisture that
absorb shock and maintain resilience.* Glucosamine stimulates and supports
the production of cartilage cells, or chondrocytes.* Contributing to
glucosamine’s effectiveness is its 98% absorption rate.*10 Once
absorbed, glucosamine sulfate is distributed primarily to joint
tissues.*10
Chondroitin sulfate
Chondroitin sulfate is a mucopolysaccharide that acts as
a structural component in connective tissue.*11 Just as glucosamine
sulfate helps attract moisture to cartilage by bonding to water,
chondroitin sulfate enhances this effect through its negative electrical
charge.11 Chondrocytes, in addition to creating new mucopolysaccharides,
also secrete enzymes that degrade old mucopolysaccharides. Chondroitin
sulfate inhibits the breakdown of cartilage, protecting the existing
tissue.*11,12,13,14
References:
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Murav’ev
IuV, Venikova MS, Pleskovskaia GN, et al. Effect of dimethyl sulfoxide
and dimethyl sulfone on a destructive process in the joints of mice
with spontaneous arthritis. Patol Fiziol Eksp Ter. 1991;2:37-9.
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Lawrence
RM. Methylsulfonylmethane (MSM): a double-blind study of its use in
degenerative arthritis. Int J of Anti-Aging Med.1998;1:50.
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Richmond
VL. Incorporation of methylsulfonyl methane sulfur into guinea pig
serum proteins. Life Sci 1986;39:263-68.
-
Jacob
S, Herschler R. Biological Actions and Medical Applications of
Dimethyl Sulfoxide, Introductory Remarks. Ann NY Acad Sci 1983;411:xiii-xvii.
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Hucker
HB, Ahmad PM, Miller EA, et al. Metabolism of Dimethyl Sulfoxide to
Dimethyl Sulfone in the Rat and Man. Nature 1966;209:619-620.
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Percy
EC, Carson JD. The use of DMSO in tennis elbow and rotator cuff
tendonitis: a double-blind study. Med Sci Sports Exerc 1981;13:215-19.
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Kneer
W, Kuhnau S, Bias P, et al. Dimethylsulfoxide (DMSO) gel in treatment
of acute tendopathies. A multicenter, placebo-controlled, randomized
study. Fortschr Med 1994;112:142-6.
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Swanson
BN. Medical use of dimethyl sulfoxide (DMSO). Rev Clin Basic Pharm
1985;5:1-33.
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Eberhardt
R, Zqingers T, Hoffman R. DMSO in patients with active gonarthrosis. A
double-blind placebo-controlled phase III study. Fortschr Med 1995;113:446-50.
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Setnikar
I, Giacchetti C, Zanolo G. Pharmacokinetics of glucosamine in the dog
and man. Arzneim Forsch 1986;36:729.
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Tapadinhas
MJ, Rivera C, Bignamini AA. Oral glucosamine sulfate in the management
of arthrosis: report on a multi-centre open investigation in Portugal.
Pharmatherapeutica 1982;3:157.
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Conte
A, Volpi n, Palmieri L, et al. Biomedical and pharmacokinetic aspects
of oral treatment with chondroitin sulfate. Arzneim-Forsch
1995;45:918-25.
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Pipitone
V, Amabanelli U, Cervini C, et al. A multicenter, triple-blind study
to evaluate galactosaminoglucuronoglycan sulfate vs. placebo in
patients with femorotibial gonarthritis. Curr Ther Res
1992;52:608-38.
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Pipitone
VR. Chondroprotection with chondroitin sulfate. Drugs Exper Clin
Res 1991
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