Saw Palmetto Extract
60 softgel capsules
Ingredients per
capsule:
Saw palmetto
extract....................................320mg
Excipients:
none
Suggested Adult Use: One to capsule daily with food.
Ingredients
Saw Palmetto Extract
Standardized Saw palmetto
berry extract, guaranteed to contain 90 percent fatty acids and
sterols.
Benefits
Effective Prostate Support
Saw palmetto
extract is one of the world's leading herbal products for
prostate support. Widely-cited clinical studies conducted over
the last fifteen years have clearly established the ability of
Saw palmetto extract to produce major improvements in
prostate-related urinary function. Saw Palmetto's key active
ingredients help to normalize prostate gland
structure.
Discussion
As men pass through and beyond middle
age, hormonal changes occur which can impact the prostate gland.
Levels of dihydrotestoterone (DHT), a normal metabolite of
testosterone, increase. This, plus an increased binding of DHT
to nuclear receptors in the prostate cell, results in growth of
prostate tissue. This tissue growth takes place in the part of
the prostate which surrounds the urethra, the tube for urine
excretion. This can constrict the urethra, resulting in urinary
disturbances.
Saw palmetto extract has been shown to inhibit
5 alpha-reductase, an enzyme that controls conversion of
testosterone to DHT. Saw palmetto extract also blocks the
binding of DHT to prostate cells. These mechanisms are believed
to account for Saw palmetto extract's positive effect on
prostate gland structure.
In clinical studies, Saw palmetto
extract has produced measurable improvements in urinary
functions and prostate size. Quality of life scores have also
improved.
The results with Saw palmetto extract have been
duplicated in open trials and controlled, double-blind
studies.
Saw palmetto extract is safe and virtually free of
side-effects.
Saw palmetto’s effectiveness comes from its
content of natural fatty acids and sterols. These include oleic
acid, lauric acid, campasterol, stigmasterol, beta-sitosterol
and others. The standard of quality for Saw palmetto extract
products is a high concentration of fatty acids and sterols,
equaling 90%.
Scientific References
1. Braeckman, J., 'The
extract of Serenoa repens in the treatment of benign prostatic
hyperplasia: a multicenter open study,' Current Therapeutic
Research 1994: 55(7):776-85.
Abstract
Because prostatic
surgery is not the treatment of choice for most patients with
benign prostatic hyperplasia (BPH), the therapeutic effect of a
160 mg, twice daily, oral dose of Serenoa repens extract was
studied during a 3-month open trial in 505 patients with mild to
moderate symptoms of BPH. The efficacy of the regimen was
evaluated in 305 of these patients. Traditional parameters for
quantifying prostatism, such as the International Prostate
Symptom Score, the quality of life score, urinary flow rates,
residual urinary volume, and prostate size, were found to be
significantly improved after only 45 days of treatment. After 90
days of treatment, a majority of patients (88%) and treating
physicians (88%) considered the therapy effective. In addition,
the serum prostate-specific antigen concentration was not
modified by the drug, thus limiting the risk of masking any
possible development of prostate cancer during treatment. The
incidence of side effects (5%) was low and compares favorably
with that reported for existing therapies used in BPH patients.
The extract of Serenoa repens appears to be an effective and
well-tolerated pharmacologic agent in treating the mictional
problems accompanying BPH.
2. Smith, H.R., et. al., 'The
value of Permixon in benign prostatic hypertrophy,' British
Journal of Urology 1986; 58:36-40.
3. Tasca, A., et. al.,
'Treatment of obstructive symptomatology caused by prostatic
adenoma with an extract of Serenoa repens. Double-blind clinical
study vs. placebo,' Minerva Urologica e Nefrologica 1985;
37:87-91.
4. Champault, G., Bonnard, A.M., Cauquil, J.,
Patel, J.C., 'Medical treatment of prostatic adenoma. A
controlled test of PA 109 vs. placebo in 110 patients,' Ann.
Urol. 1984; 18(6):407-410.
5. Crimi, A., Russo, A., 'The use
of Serenoa repens extract in the treatment of functional
disturbances caused by prostate hypertrophy,' Med. Praxis 1983;
4:47-51.
6. Sultan, C., et. al., 'Inhibition of androgen
metabolism and binding of liposterolic extract of Serenoa repens
B in human foreskin fibroblasts,' J. Steroid Biochem. 1984;
20(1):515-519.
7. El-Sheikh, M.M., Dakkak, M.R., Saddique,
A., 'The effect of Permixon on androgen receptors,' Acta Obstet
Gynecol Scand 1988: 67:397-99.
8. Niederprüm, H.J.,
Schweikert. H.U., Zänker, K.S, 'Testosterone 5 alpha-reductase
inhibition by free fatty acids from Sabal serrulata fruits,'
Phytomedicine 1994; 1:127-133.
The statements in this fact
sheet have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat,
cure or prevent any disease.
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