Celadrin® Complex with Glucosamine
90 Tablets
Each tablet
contains:
Celadrin® 500 mg
(a proprietary blend
of esterified fatty acid carbons (EFAC) of myristate,
myristolcate, laurate, oleate, palmitate, and palmitoleate with
tapioca)
Glucosamine Sulfate KCl 500
mg
Excipients: cellulose, croscarmellose sodium, silicon
dioxide.
Suggested Adult Use: Take one tablet three times
daily. Take without food.
Ingredients
Celadrin®
Celadrin® is a unique formulation
of esterified (stable) fatty acids that has been shown to reduce
certain effects related to pronounced inflammatory processes
that can occur in the body. Being a complex molecule consisting
of various fatty acids, it is able to penetrate cell membranes,
which enhances membrane permeability and cell-to-cell signaling.
In doing so, Celadrin® may reduce the level of inflammatory
components of the immune system from binding to cells and thus
causing occasional inflammation in different parts of the
body.1
Glucosamine Sulfate
Glucosamine sulfate is the most
completely studied form of glucosamine. It is commonly derived
from the exoskeleton of shellfish and is a critical nutrient
needed for the synthesis and repair of joint cartilage.
Glucosamine sulfate has the ability to stimulate the synthesis
of glycosaminoglycans and other components of the structural
matrix of joint tissue. Because of the comprehensive nature of
glucosamine sulfate's effects, it may play a role in maintaining
the health of joint tissues.2
Benefits
Increased Range
of Motion in Joints*
Research has shown that Celadrin® can
have an impact on improving the range of motion in the joints. A
placebo-controlled trial conducted in 2002 showed that those
individuals taking a complex containing Celadrin® for 2 months
had a significant improvement in knee flexion (ability to bend
the knee) over those taking a placebo.1
Another study
conducted on Celadrin® published in 2004 concluded that
treatment “significantly increased physical performance (as
measured by a variety of orthopedic tests)” in patients with
compromised knee mobility. The study found that the subjects
given Celadrin® showed improvement in their ability to climb
stairs, rise from a chair and walk, along with an improved sense
of balance, strength and endurance.3
Helps Maintain Healthy
Joint Cartilage*
Glucosamine sulfate plays a fundamental role
as a building block for joint cartilage. Evidence to date
suggests it may reduce the severity of the symptoms in
individuals with joint problems.4,5
Glucosamine sulfate has
been shown in some studies to stimulate the regeneration of
damaged cartilage, while also having anti-inflammatory effects.
Research has found that glucosamine sulfate may have a
stimulatory effect on proteoglycan production from human
cartilage cells.6
A specific 3-year placebo-controlled,
randomized study was conducted to assess the impact of taking
oral glucosamine sulfate on the progression of joint space
narrowing. Joint space narrowing may be associated with certain
degenerative conditions of articular tissue. The study found
that those individuals taking the oral glucosamine at the
recommended intake had no space narrowing on average over the
time period versus significant space narrowing in the placebo
group.7 Glucosamine sulfate may further play a role in
enhancing joint lubrication by acting to form the protective
agent mucin, a necessary component of healthy
joints.2
Maintains Joint Comfort*
The anti-inflammatory
actions of Celadrin® have been demonstrated by one double-blind,
placebo controlled trial that showed Celadrin®, when taken
orally at recommended intake levels, decreased pain scores and
increased walking distance compared to the group receiving
placebo. The authors theorize that Celadrin® may work by
down-regulating the effect of certain precursors of the body's
inflammatory response.1
In one large open trial, over 1200
people took oral glucosamine sulfate for periods ranging from 36
to 64 days. Over 252 physicians participated in this multicenter
study. 95% of the subjects experienced greater joint comfort and
increased mobility. The physicians reported "good" results in
59%, and "sufficient" results in 36%. The improvements lasted
for up to three months after the glucosamine sulfate was
discontinued.8
*These statements have not been evaluated by
the Food and Drug Administration. This product is not intended
to diagnose, treat, cure, or prevent any
disease.
Scientific References
1.Hesslink R Jr., et
al. Cetylated fatty acids improve knee function in patients
with osteoarthritis. J Rheumatology
2002;8:1708-1712.
2.Anonymous. Monograph: Glucosamine
sulfate. Alt Med Review 1999;4:3;193-195.
3.Kraemer WJ, et
al. Effect of a cetylated fatty acid topical cream on
functional mobility and quality of life of patients with
osteoarthritis. J Rheumatology 2004;4:767-74.
4.Crolle G,
D'Este E. Glucosamine sulphate for the management of arthrosis:
a controlled clinical evaluation. Curr Med Res Opin
1980;7:104-109.
5.Rovati LC. Clinical research in
osteoarthritis: design and results of short-term and long-term
trials with disease modifying drugs. Int J Tissue React
1992;14:243-51.
Acting as a biochemical "super-thiamin," it
does this through several different cellular mechanisms, as
discussed below.
6.Bassleer C, et al. Stimulation of
proteoglycan production by glucosamine sulfate in chondrocytes
isolated from human osteoarthritic articular cartilage in vitro.
Osteoarthritis and Cartilage 1998;6:427-434.
7.Pavelka K, et
al. Glucosamine sulfate use and delay of progression of knee
osteoarthritis: a 3-year, randomized, placebo-controlled,
double-blind study. Arch Intern Med. 2002 Oct
14;162(18):2113-23.
8.Macario , J. T., Rivera, I.C.
Bignamini, A.A. Oral glucosamine sulphate in the management of
arthrosis: report on a multi-centre open investigation in
Portugal . Pharmatherpeutica 1982; 3(3):157-68.
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