Best GPLC & CoQ10 featuring GlycoCarn™ contains a superior,
unique patented nutritional supplemental (Sigma-Tau Industries
US patent #6,703,042 B1) form of propionyl L-carnitine called
Glycine Propionyl L-Carnitine (an AminoCarnitine™) combined with
the complementary benefits of CoQ10 under Sigma-Tau Industries
US patent #6814972. Propionyl L-carnitine has been well studied
for its benefits in promoting the health of energy-intensive
muscular tissue, including skeletal muscle and the heart.
Propionyl L-carnitine has been shown to increase cellular
L-carnitine production. The amino acid L-carnitine facilitates
the process of energy production in muscle cells.* Propionyl
L-carnitine is also known to exhibit significant free radical
scavenging activity in the circulatory and cardiovascular
systems.* Studies have also shown that propionyl L-carnitine may
increase exercise capacity and overall energy in athletes and
supports the overall metabolism of fat.*
CoQ10 is a
versatile antioxidant, which stabilizes cell membranes,
protecting them from free radical damage.* CoQ10 also supports
heart function and promotes energy production in cells.* Heart
muscle is the most energy-intensive tissue in the entire body.
Best GPLC & CoQ10 featuring GlycoCarn™ combines the powerful
cardiovascular support of two potent nutrients into one
synergistic formulation designed to optimally support heart and
muscle function.*
Ingredients
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Benefits
· Supports Energy Production in Heart
Tissue*
Propionyl L-carnitine is a natural component of the
body’s carnitine pool. Research has shown that it mediates
several metabolic effects that may result in enhanced muscle
function. Studies indicate that propionyl L-carnitine stimulates
the efficiency of energy production in the Krebs’ cycle during
conditions in which oxygen levels are low. Propionyl L-carnitine
supplies the usable substrate propionate, which can be utilized
by the body to produce the Krebs’ intermediate succinate,
increasing the efficiency of energy production in vascular
tissue. Research suggests that individuals supplementing with
propionyl L-carnitine have improved maximal exercise duration
and oxygen consumption over those given a placebo.1 A major
mechanism of action of carnitine and propionyl L-carnitine in
supporting heart function, therefore, appears to be their
ability to increase the availability of substrates for energy
production in muscle tissue. However, propionyl L-carnitine also
has antioxidant activity, protecting tissue from the ravages of
oxidative stress.2
Coenzyme Q10 is a vitamin-like
nutrient found in the human body. CoQ10 works at the cellular
level to produce energy for metabolism in the form of ATP.3,4
CoQ10 serves as an important cofactor in the "electron transport
chain," which is the final step in the production of ATP in the
mitochondria of cells. Without an adequate supply of CoQ10,
cells can become energy-deficient, slowing down a number of
critical cellular processes. When cells are nourished with
adequate levels of CoQ10, tissues, organs and systems function
properly.
· Enhances Cardiovascular and Muscle
Function*
Research has shown that the nutrients propionyl
L-carnitine and coenzyme Q10 are essential for optimal
cardiovascular and skeletal muscle function, as both play major
roles in supporting the healthy functioning of heart tissue.
Research findings point to the fact that tissue levels of CoQ10
decrease with age. Similar research in animals and humans
demonstrate a decrease in tissue L-carnitine levels, resulting
in decreased integrity of mitochondrial membranes.5
Supplementation and replenishment of both nutritional factors
may be essential in maintaining healthy cardiac and skeletal
muscle function as we age.
Propionyl L-carnitine has
been extensively studied in animals and in human clinical
trials. The results of this research suggest an enhancement in
multiple parameters of heart function with the administration of
propionyl L-carnitine. In a rat study of chemically-induced
heart toxicity, the administration of propionyl L-carnitine for
2 weeks supported normal beta-oxidation of fatty acids, mediated
or induced antioxidant defenses to protect the integrity of
heart cell membranes against oxidative damage caused by the
chemical agent, and supported normal cardiac function.6 Human
clinical trials of propionyl L-carnitine supplementation show
that the nutrient may promote healthy circulatory function,
enhance exercise performance, support healthy energy levels and
increase muscle strength.7,8,9
Additional research
suggests CoQ10 has the ability to enhance the contractile
function of heart muscle. The heart is the hardest working
muscle in the body. Because of its high energy requirements,
the heart needs CoQ10 at all times. The highest concentration of
CoQ10 in the human body occurs in heart muscle tissue. Numerous
clinical studies have demonstrated significant improvements in
heart function with oral administration of CoQ10.10,11,12
While CoQ10 has direct benefits in heart muscle, a parallel
mechanism for its protective effect on cardiovascular tissue is
likely its potent antioxidant abilities. The reduced form of
CoQ10, ubiquinol-10, has been found to protect LDL against
oxidative damage by free radicals more effectively than vitamin
E. CoQ10 stabilizes cell membranes, protecting them from free
radical damage.13,14,15 Along with conferring protection to
cardiovascular and other tissues, CoQ10 has also been shown to
enhance the levels of other antioxidant vitamins in circulation,
such as vitamins, A, C and E.16
· Promotes
Fat Metabolism*
As mentioned above, propionyl L-carnitine
supplementation can increase plasma concentration of
L-carnitine.8 L-carnitine promotes energy production in cells by
transporting fatty acids into the mitochondrion. Its primary
function is to transfer long-chain fatty acids across the inner
mitochondrial membrane. Fatty acid molecules are activated to
coenzyme A (CoA) esters in the cytoplasm of the cell, and then
attached to an L-carnitine molecule. The combination of a fatty
acid molecule and L-carnitine is called “acyl-carnitine.” Much
of the body L-carnitine content is stored in the form of
acyl-carnitine.
L-carnitine is required as a transporter
to facilitate the passage of fatty acids across the
mitochondrial membrane, catalyzing their metabolism for energy
production. On the inside of the mitochondrial membrane, the
acyl-CoA esters are made available to be metabolized through the
process of beta-oxidation. One of the key metabolic byproducts
of this process is acetyl-CoA, which enters the Krebs’ cycle to
supply fuel for production of ATP, the cell’s primary energy
supply. L-carnitine also facilitates the removal of excess
short and medium chain fatty acids from the mitochondria that
accumulate during cellular metabolism.5 L-carnitine is then
recycled by the body and shuttled back across the mitochondrial
membrane to facilitate the process again.17 Since the heart is
dependent on fatty acid oxidation for its functionality,
L-carnitine is an essential cofactor for optimal heart
health.
Best GPLC & CoQ10 featuring GlycoCarn™
provides heart-healthy levels of propionyl L-carnitine and CoQ10
in a single formulation. Both nutrients complement each other to
support energy production in heart tissue, enhance
cardiovascular and muscle health, and promote optimal fat
metabolism.*
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Safety
Suggested Adult Use:
Take 1 capsule daily.
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