PureWay C Sustained Release Vitamin C
Supplement
Facts:
Serving size 1 tablet
servings per container: 60
servings
Vitamin C
....................................500mg
(as Pureway-C and
ascorbyl palmitate)
Citrus
bioflavonoids..........................50mg
other
ingredients: hydroxypropyl methylcellulose, vegetable fatty
acids, magnesium stearate (vegetable source) and silicon
dioxide.
suggested adult use: for continous 24 hour vitamin
C coverage, take one tablet every 12 hours
PureWay-C®
Sustained Release Vitamin C contains PureWay-C®, a newly
discovered form of vitamin C consisting of highly absorbable
vitamin C-lipid metabolites. Vitamin C-lipid metabolites have
faster and more beneficial effects than other forms of vitamin C
[1]. PureWay-C® Sustained Release Vitamin C also contains citrus
bioflavonoids and ascorbyl palmitate. Ascorbyl palmitate is a
fat-soluble form of vitamin C that is able to be stored in lipid
cell membranes for later use. Citrus bioflavonoids include the
flavonones, such as hesperidin and naringin, as well as the
polymethoxylated flavones, such as tangeretin and nobiletin.
Bioflavonoids, and citrus bioflavonoids in particular, work in
conjunction with vitamin C to improve absorption and boost its
effects [2].
The PureWay-C® formulation allows for
better cellular uptake and absorption of vitamin C.* This
enhances the opportunity for vitamin C to take part in its wide
range of support for the human body.* Vitamin C is the main
water-soluble nutrient antioxidant in human plasma and has many
functions. It is a potent free radical scavenger, immune
enhancer, and cell protector.* It maintains collagen, helps form
red blood cells, aids in the absorption of iron, stimulates
adrenal function, and helps detoxify certain metals and drugs.
It also plays a role in the synthesis of mood-enhancing
neurotransmitters, in cholesterol metabolism, and in mediating
inflammation.* Citrus bioflavonoids are also antioxidants with
their own powerful biological effects including modulation of
the immune system, anti-inflammatory activity, and protection of
the nervous system.*
Contains Vitamin C-lipid
Metabolites (PureWay-C®):
PureWay-C® is a novel vitamin C
preparation containing vitamin C-lipid metabolites. Studies in
the laboratory show that human cells absorb this new form of
vitamin C more rapidly and in greater amounts than the three
most popular forms of vitamin C: ascorbic acid, calcium
ascorbate and calcium ascorbate-calcium
threonate-dehydroascorbate.*
Laboratory (in vitro)
research also shows that PureWay-C®:
* Protects
the nervous system by promoting the survival of nerve cells
*
* Protects the immune system against damage induced
by pesticides *
* Delivers effective antioxidant and
free radical scavenging activity *
* Enhances normal
wound healing by improving the functioning of collagen-secreting
fibroblast cells *
Human clinical studies conducted with
PureWay-C® also show:
* PureWay-C® is better absorbed
and retained in the serum at higher levels.*
*
PureWay-C® decreases blood levels of a common marker of an
imbalanced immune response.*
* PureWay-C® decreases
blood levels of a common marker of oxidative stress (cellular
degeneration resulting from free radical
production).*
Delivers Effective Antioxidant and Free
Radical Scavenging Activity to Decrease Markers of Oxidative
Stress*
The PureWay-C® vitamin C-lipid metabolite
formulation has potent antioxidant and free radical scavenging
capabilities based on ORAC and DPPH assays, two methods commonly
used to evaluate antioxidant capacities. PureWay-C® reached 93%
scavenging capability using the DPPH assay, indicative of an
excellent free radical scavenger. PureWay-C® has 1343 units of
antioxidant activity per gram based on ORAC analysis (ORAC
values are in ìM Trolox® Equivalents/gram of substance), showing
stronger antioxidant activity on a gram basis than some other
common natural sources of antioxidants such as green and black
teas (235-1526 ORAC units), cinnamon (1243), and broccoli
(65.8-121.6) [1].*
In order for vitamin C to exert its
antioxidant benefits, it must be able to get inside cells.
PureWay-C® was tested for its ability to be taken up and
retained in the cell, and for the rate at which it is able to do
so. Compared to ascorbic acid, the most common form of vitamin
C, PureWay-C® showed a 233% increase in cellular uptake into
human T-lymphocytes at both 30 and 45 minutes. This absorption
level was a 122% improvement over the next best form of vitamin
C, calcium ascorbate-calcium threonate-dehydroascorbate. The
absorbed levels peaked at approximately two hours with the
cellular level of PureWay-C® at 50 nmol / mg [1].
In
order to assess absorption in humans, PureWay-C® serum levels
were measured in healthy volunteers after oral supplementation.
Forty volunteers maintained a low vitamin C diet for 14 days
and, following an overnight fast, received a single oral dose of
1000 mg of either ascorbic acid, calcium ascorbate, PureWay-C®,
or calcium ascorbate-calcium threonate-dehydroascorbate. Blood
samples were collected immediately prior to the oral dose
administration and at various times after ingestion. Serum
vitamin C levels were measured, and PureWay-C® supplementation
led to the highest absolute serum vitamin C levels when compared
to the other forms of vitamin C. At two hours, PureWay-C® levels
were statistically significantly higher than ascorbic acid and
calcium ascorbate. At 24 hours post treatment, PureWay-C®
maintained the highest serum levels of vitamin C [3].
Supports the Body’s Immune System*
Excessive, chronic,
or unbalanced immune activation is associated with a variety of
health problems. High levels of certain proteins in the blood
serve as indicators of this unhealthy condition. Levels of
vitamin C in the blood have been found to be inversely
associated with these protein markers of unbalanced immune
activation [4]. Recent research has attributed much of the
beneficial immune-related effects of vitamin C supplementation
to the reduction of circulating levels of these markers [5].
To test the effects of vitamin C on levels of these markers in
humans, forty volunteers maintained a low vitamin C diet for 14
days and, following an overnight fast, received a single oral
dose of 1000 mg of either ascorbic acid, calcium ascorbate,
PureWay-C®, or calcium ascorbate-calcium
threonate-dehydroascorbate. Blood samples were collected
immediately prior to the oral dose administration and at various
times after ingestion. Plasma levels of two markers of
unbalanced immune activation were measured by enzyme linked
immunosorbent assay (ELISA). Oral supplementation with
PureWay-C® led to greater reductions in plasma levels of these
markers compared to the other vitamin C formulations. Overall,
PureWay-C® supplementation resulted in greater and more
beneficial effects than what was observed with the other forms
of vitamin C [3].
Laboratory testing also indicates
PureWay-C® has a greater protective effect on immune cells that
have been exposed to toxins and pesticides.* PureWay-C® is more
active and effective than ascorbic acid, calcium ascorbate and
other popular forms of vitamin C in reducing hyperactivity of
white blood cells and inflammatory damage caused by substances
that are foreign to the body.* Human T-lymphocytes are white
blood cells that aggregate or clump together when exposed in the
laboratory to toxins such as the common pesticide bifenthrin or
the toxin phytohemagglutinin (PHA). These immune cells were
treated in vitro with bifenthrin and PHA, and then either given
no further treatments or treated further with PureWay-C® or
other popular ascorbate brands. The cells were then incubated
and the number of cells per aggregate was determined. PureWay-C®
reduced PHA-induced T-cell aggregation, a marker of inflammatory
hyperactivation, more than other popular forms of vitamin C [6].
When these immune cells were treated with the pesticide
bifenthrin, along with various formulations of vitamin C, all of
the vitamin C formulations reduced the pesticide-mediated
aggregation. However, the effect of PureWay-C® on inhibiting the
aggregation was at least double the effect of the next best
vitamin C formulation [6].
Various citrus bioflavonoids
also possess a wide range of immune and inflammation- related
therapeutic properties [7]. Immune and inflammation responses
are controlled by enzymes and cytokines produced in the body
such as TNF-alpha, a pro-inflammatory cytokine. Citrus
bioflavonoids can inhibit these enzymes and cytokines to
decrease inflammatory responses in vitro [8]. In vitro studies
also indicate how bioflavonoids modulate inflammation through a
number of other mechanisms, such as inhibition of gene
expression in the cells lining blood and lymph vessels [7]. In
these ways, bioflavonoids may support overall immune health and
wellness.
Supports a Healthy Cardiovascular
System*
Most prospective studies assessing vitamin C
intake in large numbers of people who are followed over time
indicate that the highest intakes of vitamin C are associated
with enhanced cardiovascular benefits. In addition, some large
studies in healthy individuals who take vitamin C supplements
suggest that vitamin C supplements support normal heart
function. The Nurses’ Health Study of more than 85,000 women
followed for over 16 years found vitamin C intakes of more than
359 mg per day from diet plus supplements or from supplements
alone were associated with a 27-28% reduction in cardiovascular
risk factors [9]. In a recent review of studies in which more
than 290,000 healthy adults were followed for an average of 10
years, those who took more than 700 mg per day of supplemental
vitamin C had a substantially better cardiovascular profile than
those who did not take vitamin C supplements [10].
One of the
ways vitamin C may enhance cardiovascular health is by
supporting levels of good cholesterol (HDL) that are already
within the normal range. Researchers from the National Institute
on Aging and the USDA investigated the effect of vitamin C
intake on lipid metabolism [11]. After adjustment for age, sex,
obesity, and smoking, they found that in healthy adults with
adequate vitamin C intake there was a significant positive
association between high levels of plasma vitamin C and healthy
lipid ratios. The research suggested that higher concentrations
of vitamin C in the blood, the result of taking up to two to
three times the RDA, are associated with improved cardiovascular
health.
Epidemiological and animal studies suggest that
citrus bioflavonoids also support healthy cardiovascular
function and circulation [12]. An analysis of the flavonoid
intake of 34,489 postmenopausal women in the sixteen-year Iowa
Women's Health Study found significant positive correlations
between flavonone and flavone intake and cardiovascular function
[13]. These two categories of flavonoids, flavonones and
flavones, are the primary flavonoids found in citrus fruit.
Hypothesized mechanisms by which flavonoids may have
cardioprotective effects include antioxidant protection of lipid
molecules, anti-inflammatory action, improvement in endothelial
function, and enhancement of circulation [14,
15].
Protects the Body’s Nervous System*
Vitamin C
is thought to protect the nervous system from degeneration. In
order for nerve cells to survive, the body secretes a critical
protein called nerve growth factor (NGF). In the laboratory,
vitamin C formulations enhance the NGF-mediated growth of nerve
cells. In vitro research indicates that compared to other forms
of vitamin C, PureWay-C® is more beneficial to the nervous
system. Nerve cells were treated with 100 ng/ml of NGF, and
incubated for a 24-hour period. These cells then received either
no further treatment, or treatment with 0.5 ìM of ascorbic acid,
calcium ascorbate, PureWay-C® or other ascorbate brands. After
these treatments, the cells were incubated over another 24-hour
period during which the formation of developing nerve cells was
assessed at hours 1, 3, 6, 9, 12 and 24. Compared with the other
forms of vitamin C, PureWay-C® significantly increased the
formation of developing nerve cells [6].
Citrus
bioflavonoids have also demonstrated neuroprotective effects in
laboratory and animal models. Hesperidin, for instance, has the
ability to cross the blood brain barrier and act on the central
nervous system [16]. Hesperidin and related citrus bioflavonoids
protect nerve cells against oxidative damage in vitro [16]. Even
at physiological concentrations, these flavonoids significantly
protected cells of the nervous system from hydrogen
peroxide-induced oxidative damage. Hydrogen peroxide is formed
in the brain under certain conditions, and quickly converts to
highly toxic hydroxy radicals that damage nerve
cells.
Safety
Suggested Adult Use: For continuous
24 hour Vitamin C coverage take one tablet every 12
hours.
Does Not Contain: milk, egg, wheat, corn, sugar,
sweeteners, starch, salt, or preservatives.
Scientific
References
1. Weeks, B.S. and P.P. Perez, Absorption
rates and free radical scavenging values of vitamin C-lipid
metabolites in human lymphoblastic cells. Med Sci Monit, 2007.
13(10): p. BR205-10.
2. Vinson, J.A. and P. Bose,
Comparative bioavailability to humans of ascorbic acid alone or
in a citrus extract. Am J Clin Nutr, 1988. 48(3): p. 601-4.
3. Pancorbo, D., C. Vazquez, and M. Fletcher, Vitamin C-lipid
metabolites: Uptake and Retention and Effect on Plasma
C-Reactive Protein and Oxidized LDL Levels in Healthy
Volunteers. 2007, Comprehensive HealthCare of Miami, LLC:
Miami.
4. Wannamethee, S.G., et al., Associations of
vitamin C status, fruit and vegetable intakes, and markers of
inflammation and hemostasis. Am J Clin Nutr, 2006. 83(3): p.
567-74; quiz 726-7.
5. Sanchez-Moreno, C., A.
Jimenez-Escrig, and F. Saura-Calixto, Study of low-density
lipoprotein oxidizability indexes to measure the antioxidant
activity of dietary polyphenols. Nutrition Research, 2000.
20(7): p. 941-953.
6. Weeks, B.S. and P.P. Perez, A
novel vitamin C preparation enhances neurite formation and
fibroblast adhesion and reduces xenobiotic-induced T-cell
hyperactivation. Med Sci Monit, 2007. 13(3): p. BR51-8.
7. Manthey, J.A., K. Grohmann, and N. Guthrie, Biological
properties of citrus flavonoids pertaining to cancer and
inflammation. Curr Med Chem, 2001. 8(2): p. 135-53.
8.
Delaney, B., et al., Immunotoxicity of a standardized citrus
polymethoxylated flavone extract. Food Chem Toxicol, 2001.
39(11): p. 1087-94.
9. Osganian, S.K., et al., Vitamin
C and risk of coronary heart disease in women. J Am Coll
Cardiol, 2003. 42(2): p. 246-52.
10. Knekt, P., et al.,
Antioxidant vitamins and coronary heart disease risk: a pooled
analysis of 9 cohorts. Am J Clin Nutr, 2004. 80(6): p.
1508-20.
11. Hallfrisch, J., et al., High plasma
vitamin C associated with high plasma HDL- and HDL2 cholesterol.
Am J Clin Nutr, 1994. 60(1): p. 100-5.
12. Knekt, P.,
et al., Flavonoid intake and risk of chronic diseases. Am J Clin
Nutr, 2002. 76(3): p. 560-8.
13. Mink, P.J., et al.,
Flavonoid intake and cardiovascular disease mortality: a
prospective study in postmenopausal women. Am J Clin Nutr, 2007.
85(3): p. 895-909.
14. O'Byrne, D.J., et al.,
Comparison of the antioxidant effects of Concord grape juice
flavonoids alpha-tocopherol on markers of oxidative stress in
healthy adults. Am J Clin Nutr, 2002. 76(6): p. 1367-74.
15. Vita, J.A., Polyphenols and cardiovascular disease: effects
on endothelial and platelet function. Am J Clin Nutr, 2005. 81(1
Suppl): p. 292S-297S.
16. Hwang, S.L. and G.C. Yen,
Neuroprotective effects of the citrus flavanones against
H2O2-induced cytotoxicity in PC12 cells. J Agric Food Chem,
2008. 56(3): p. 859-64.
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