Best Glucosamine Sulfate Sodium Free
500mg: 150C & 300C —
750mg: 180c
Excipients: gelatine capsuel, rice powder,
stearic acid, magnesium stearate, silica
Suggested Use: One
capsule three times daily.
Ingredients
Best
Glucosamine Sulfate contains pure glucosamine sulfate, as
confirmed by HPLC testing. Glucosamine sulfate consists of
glucosamine, an amino sugar extracted from shellfish skeletons.
"Chitin", the resilient polysaccharide that forms the structural
framework of animal shells, is a long-chain polymer consisting
of many glucosamine molecules linked together. The purified
glucosamine is then sulfated and stabilized with potassium
chloride. Note: Best Glucosamine Sulfate is sodium-free. It
contains 24-26% potassium chloride.
Benefits
Supplies the
body with building material for cartilage*
Cartilage, a
“connective tissue,” is composed of cells (chondrocytes),
protein fibers (chiefly collagen) and clusters of complex
molecules called “proteoglycans.” A proteoglycan consists of a
long protein (polypeptide) with many side chains attached to it.
(The structure of proteoglycan looks somewhat like a test-tube
brush.) The attached side chains are polysaccharides-chiefly
chondroitin sulfate and keratin sulfate.1,2 Glucosamine is a key
component of keratin sulfate.2 Glucosamine is also a component
of hyaluronic acid, another glycosaminoglycan found in cartilage
and other connective tissues. Hyaluronic acid forms the backbone
for the proteoglycan clusters.2 Glycosaminoglycans have a strong
attraction for water. The water-holding ability of proteoglycan
clusters to hold water gives cartilage its strong, sponge-like
quality. It also allows nutrients to flow into cartilage and
wastes to flow out.2
Supports Joint Structure and
Function*
Glucosamine sulfate is one the most important
nutritional supplements for joint health ever developed.
Glucosamine sulfate provides significant benefits for both the
structure and function of joints. Many years of research have
produced unequivocal evidence that glucosamine sulfate
normalizes cartilage metabolism, slows breakdown of cartilage,
and improves joint function.3,4,5
Glucosamine sulfate has been
thoroughly researched over the last 20 years. Experimental
studies and human clinical trials convincingly demonstrate that
orally consumed glucosamine sulfate improves joint function.
In
one large open trial, over 1200 people took oral glucosamine
sulfate for periods ranging from 36 to 64 days. 252 physicians
participated in this multi-center study. 95% of the subjects
experienced greater joint comfort and increased mobility. The
physicians reported “good” results in 59%, and “sufficient”
results in 36%. The improvements lasted for up to three months
after the glucosamine sulfate was discontinued.4
The
effectiveness of glucosamine sulfate for joint health has been
shown in double-blind, placebo-controlled research. One study
compared glucosamine sulfate to “ibuprofen,” a commonly used
pain medication, over an eight week period. During the first two
weeks, better results were seen with ibuprofen, but by the
eighth week, glucosamine sulfate produced greater improvements
in pain scores.5
Provides Sulfur, the Key Structural Mineral
in Cartilage*
Sulfur, one of the body’s essential structural
minerals, is incorporated into the structure of
glycosaminoglycans such as chondroitin sulfate and keratin
sulfate.1,2
Why Potassium-Stabilized Glucosamine Sulfate is
Preferable
In order for glucosamine sulfate to be processed for
oral consumption as a supplement, it must be stabilized with
either sodium or potassium. Either mineral works for this
purpose. Potassium is preferable for numerous reasons; many
people are on sodium-restricted diets, and the Standard American
Diet tends to be high in sodium and low in potassium. Moreover,
studies have found people needing joint support to be low in
both salivary potassium and total body
potassium.6,7,8
Scientific References and Abstracts
1.
Bland, J.H., Cooper, S.M. Osteoarthritis: A review of the cell
biology involved and evidence for reversibility. Management
rationally related to known genesis and pathophysiology.
Seminars in Arthritis and Rheumatism 1984;14(2):106-133.
2.
Hardingham, T. Proteoglycans: Their structure, interactions and
molecular organization in cartilage. Biochemical Society
Transactions 1981;9(6):489-97.
3. Vidal y Plana, R.R.,
Bizzarri, D., Rovati, A.L., “Articular cartilage pharmacology:
I. In vitro studies on glucosamine and non-steroidal
anti-inflammatory drugs,” Pharmacological Research
Communications 1978; 10(6):557-569.
4. Macario , J. T., Rivera,
I.C., Bignamini, A.A., ‘Oral glucosamine sulfate in the
management of arthrosis: report on a multi-center open
investigation in Portugal,’ Pharmatherpeutica 1982;
3(3):157-68.
Abstract: An open study was carried out by 252
doctors throughout Portugal to assess the effectiveness and
tolerability of oral glucosamine sulfate in the treatment of
arthrosis. Patients received 1.5 g daily in 3 divided doses over
a mean period of 50 ±14 days. The results from 1208 patients
were analyzed and showed that the symptoms of pain at rest, on
standing and on exercise and limited active and passive
movements improved steadily throughout the treatment period. The
improvement lasted for a period of 6 to 12 weeks after the end
of treatment. Objective therapeutic efficacy was rated by the
doctors as ‘good’ in 59% of the patients, and ‘sufficient’ in a
further 36%. These results were significantly better than those
obtained with previous treatments (except for injectable
glucosamine sulfate) in the same patients. Sex, age,
localization of arthrosis, concomitant illnesses or concomitant
treatments did not influence the frequency of responders to
treatment. Oral glucosamine sulfate was fully tolerated by 86%
of patients, a significantly larger proportion than that
previously reported with other previous treatments and
approached only by injectable glucosamine. The onset of possible
side-effects was significantly related to pre-existing
gastrointestinal disorders and related treatments, and to
concomitant diuretic treatment.
5. Vaz, A.L., ‘Double-blind
clinical evaluation of the relative efficacy of ibuprofen and
glucosamine sulfate in the management of osteoarthrosis of the
knee in out-patients,’ Current Medical Research and Opinion
1982; 8(3):145-149.
Abstract: A double-blind trial was carried
out in 40 outpatients with unilateral osteoarthrosis of the knee
to compare the efficacy and tolerance of oral treatment with
1.5g glucosamine sulfate or 1.2g ibuprofen daily over a period
of 8 weeks. Pain scores decreased faster during the first 2
weeks in the ibuprofen than in the glucosamine treatment group.
Although the rate of decrease was slower, the reduction in pain
scores was continued throughout the trial period in patients on
glucosamine and the difference between the two groups turned
significantly in favor of glucosamine at Week 8. No significant
differences were observed in swelling or any of the other
parameters monitored. Tolerance was satisfactory with both
treatments, with only minor complaints being reported by 2
patients on glucosamine compared with 5 patients on
ibuprofen.
6. Siamopoulou, A. et. al. Sialochemistry in
juvenile chronic arthritis. British Journal of Rheumatology
1989;28(5):383-5.
7. Syrjanen, S. et. al. Salivary and serum
levels of electrolytes and immunomarkers in edentulous healthy
subjects and in those with rheumatoid arthritis. Clinical
Rheumatology 1986;5(1):49-55.
8. Sambrook, P.N., et. al. Bone
turnover in early rheumatoid arthritis. 1. Biochemical and
kinetic indexes. Annals of the Rheumatic Diseases
1985;44(9):575-9.
*This statement has not been evaluated by
the Food and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
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General Information and datasheet (Doctors Best)
