GABA
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• Increase Growth Hormone
• Enhance
Recovery
• Promote Restful Sleep
• Reduce Body Fat
• Increase
Lean Muscle Mass
GABA, Gamma Aminobutyric Acid, is an amino
acid classified as a neurotransmitter (A neurotransmitter is a
substance that transmits nerve impulses across a synapse. A
synapse is a region where nerve impulses are transmitted across
axon terminals.)
"Studies Show A 550% Increase In Growth
Hormone Levels With Just 5 Grams Of GABA!"
GABA’s high
concentration in the hypothalamus suggests this amino acid plays
a significant role in hypothalamic-pituitary function. The
hypothalamus is a region of the posterior section of the brain
and is the regulating center for visceral (instinctive)
functions such as sleep cycles, body temperature, and the
activity of the pituitary gland.
The pituitary gland is the
master endocrine gland effecting all hormonal functions of the
body. One primary hormone of concern to the athlete is growth
hormone (GH) and its various hormonal constituents.
The
amino acid GABA has been shown in numerous studies to promote
significant increases in plasma growth hormone levels.
There
have been literally hundreds of clinical studies on GABA and
numerous studies on GABA’s ability to elevate growth hormone
levels. As with most nutritional studies, GABA research has come
directly from the medical community. One noted study from the
First Medical Clinic at the University of Milan in Milan, Italy
titled, “Effect of acute and repeated administration of gamma
aminobutyric acid (GABA) on growth hormone and prolactin
secretion in man”, shows just how effective GABA is.
Quoted
results from this study showed “In all of the 19 subjects
studied, compared with 18 controls, plasma growth hormone levels
were significantly increased (above 5 ng/ml) by acute oral
administration of 5 g of GABA.”
This study showed over a 5
1/2 fold increase in plasma growth hormone levels 90 minutes
after GABA administration. That is a significant increase
unmatched by any other nutritional means.
Most cited studies
on amino acids and growth hormone elevation utilize intravenous
delivery means. This is unrealistic and doesn’t reflect real
world results. Studies on GABA have been performed with both
oral and intravenous administration with the oral route showing
remarkable effectiveness.
GABA’s growth hormone elevating
effects rival that of potent pharmaceutical compounds.
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References:
1. Involvement of growth
hormone-releasing factor in growth hormone secretion induced by
gamma-aminobutyric acid in conscious rats. Murakami Y, 1985
Endocrinology 117(2), 787-789 (1985)
2. Evidence for a
GABAergic control of the exercise-induced rise in GH in man.
Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Eur J Clin
Pharmacol 28 (5): 607-609 (1985)
3. Growth hormone secretion
of the neonatal rat pituitaries is stimulated by
gamma-aminobutyric acid in vitro. Acs Z, Makara GB, Stark E Life
Sci 34 (16): 1505-1511 (Apr 1984)
4. Gamma aminobutyric acid
(GABA), a modulator of anterior pituitary hormone secretion by
hypothalamic and pituitary action. McCann SM, Vijayan E,
Negro-Vilar A, Mizunuma H, Mangat H Psychoneuroendocrinology 9
(2): 97-106 (1984)
5. Effect of gamma-aminobutyric acid on
growth hormone and prolactin secretion in man: influence of
pimozide and domperidone. Cavagnini F, Benetti G, Invitti C,
Ramella G, Pinto M, Lazza M, Dubini A, Marelli A, Muller EE J
Clin Endocrinol Metab 51 (4): 789-792 (Oct 1980)
6. Effects
of some gamma-aminobutyric acid (GABA)-ergic drugs on the
dopaminergic control of human growth hormone secretion. Koulu M,
Lammintausta R, Dahlstrom S J Clin Endocrinol Metab 51 (1):
124-129 (Jul 1980)
7. Effect of acute and repeated
administration of gamma aminobutyric acid (GABA) on growth
hormone and prolactin secretion in man. Cavagnini F, Invitti C,
Pinto M, Maraschini C, Di Landro A, Dubini A, Marelli A Acta
Endocrinol (Copenh) 93 (2): 149-154 (Feb 1980)
"A single
oral dose of 5 g gamma aminobutyric acid (GABA) was given to 19
subjects and serial venous blood samples were obtained before
and 3 h after drug administration. A placebo was administered to
18 subjects who served as controls. GABA caused a significant
elevation of plasma growth hormone levels (P less than 0.001),
but did not consistently alter plasma prolactin concentration
since only 5 out of 15 subjects showed an increase of the
hormone. Eight additional subjects were submitted to an insulin
tolerance test before and after per os administration of 18 g
GABA daily for 4 days. Protracted GABA treatment significantly
blunted the response of growth hormone and enhanced that of
prolactin to insulin hypoglycaemia (P less than 0.01). These
results indicate that pharmacological doses of GABA affect
growth hormone and prolactin secretion in man. The precise
nature of GABA's effects as well as its mechanism of action
remains to be clarified."
8. Growth hormone release by
gamma-aminobutyric acid (GABA) and
gamma-amino-beta-hydroxybutyric acid (GABOB) in the rat. Abe H,
Kato Y, Chihara K, Ohgo S, Iwasaki YEndocrinol Jpn 24 (2):
229-231 (Apr 1977)
9. Regulation of growth hormone secretion
Kato Y, Chihara K, Daigo S, Iwasaki Y, Abe H Horumon To Rinsho
25 (2): 131-141 (Feb 1977)
10. Pharmacological evidence for
a dual GABAergic regulation of growth hormone release in humans.
Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Life Sci 39
(11): 979-985 (Sep 1986)
11. Involvement of alpha-adrenergic
and GABAergic mechanisms in growth hormone secretion induced by
central somatostatin in rats. Murakami Y, Kato Y, Koshiyama H,
Inoue T, Ishikawa Y, Imura H Brain Res 407 (2): 405-408 (Mar
1987)
12. Evidence for a sex difference in the basal growth
hormone response to GABAergic stimulation in humans. Monteleone
P, Maj M, Iovino M, Steardo L Acta Endocrinol (Copenh) 119 (3):
353-357 (Nov 1988)
13. Role of hypothalamic factors
(growth-hormone-releasing hormone and gamma-aminobutyric acid)
in the regulation of growth hormone secretion in the neonatal
and adult rat. Acs Z, Lonart G, Makara GB Neuroendocrinology 52
(2): 156-160 (Aug 1990)
14. Possible mediation of GABA
induced growth hormone secretion by increased calcium-flux in
neonatal pituitaries. Acs Z, Zsom L, Makara GB Life Sci 50 (4):
273-279 (1992)
15. Potent agonists of growth
hormone-releasing hormone. II. Zarandi M, Serfozo P, Zsigo J,
Deutch AH, Janaky T, Olsen DB, Bajusz S, Schally AV Pept Res 5
(4): 190-193 (Jul 1992)
16. New Gaba-containing analogues of
human growth hormone-releasing hormone (1-30)-amide: I.
Synthesis and in vitro biological activity. Mezo I, Kovacs M,
Szoke B, Szabo EZ, Horvath J, Makara GB, Rappay G, Tamas J,
Teplan I J Endocrinol Invest 16 (10): 793-798 (Nov 1993)
17.
Neuroendocrine regulation of growth hormone secretion in sheep.
VII. Effects of GABA. Spencer GS, Berry CJ, Bass JJ Regul Pept
52 (3): 181-186 (Aug 1994)
18. Growth hormone secretion and
activation of cyclic AMP by growth hormone releasing hormone and
gamma-aminobutyric acid in the neonatal rat pituitary. Mergl Z,
Acs Z, Makara GB Life Sci 56 (8): 579-585 (1995)
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General Information and datasheet (AST)
