ESTROGENEX is a nutritional supplement, available without a
prescription, designed to normalize all hormone levels, yielding
a wide spectrum of health and anti-aging benefits.
ESTROGENEX
is a multi-pathway formulation that minimizes or eliminates the
undesirable effects associated with an estrogen dominant
environment. ESTROGENEX maintains the correct testosterone to
estrogen ratios that yield the benefits associated with normal
estrogen levels. ESTROGENEX acts as an irreversible
anti-aromatase agent and is thus a powerful elevator of total
testosterone and maximum liberator of free testosterone.
ESTROGENEX may also play a role in long-term selective estrogen
blocking and/or inhibition of selective estrogen signaling.
ESTROGENEX may contribute to notable improvements in muscular
growth and fat loss, in addition to its wide array of health and
anti-aging benefits.
ESTROGENEX is designed for:
Normalization of all hormone levels, with specific tendencies
toward testosterone dominance, in all aging males.
Prevention
and reversal of Gynecomastia.
Adjunctive supplementation for
men undergoing hormone replacement therapy to ensure that
raising testosterone levels will not yield an undesirable
increase in estrogen levels.
A natural, more effective
alternative for traditional testosterone hormone replacement
therapy.
Bodybuilders and athletes during and immediately
after periods of anabolic steroid use for the purpose of
stimulating endogenous testosterone production.
Testosterone:
Free-Testosterone and Plasma Protein-Bound
Testosterone
Testosterone exists in the blood in either an
active (free) or unbound state (+-2%) or inactive state bound to
one of two proteins: sex-hormone-binding-globulin (SHBG) (+-45%)
or albumin (+-53%). Only when testosterone is in its free state
can it directly interact with cellular receptors and exert its
activity. SHBG preferentially binds to testosterone over
estrogen. Higher levels of SHBG in women help to maintain higher
estrogen to testosterone ratios. Increased estrogen leads to an
increase in SHBG. Thus, lowering the level of SHBG allows for an
increased level of free testosterone. Obviously, if testosterone
finds it more difficult to locate available plasma proteins in
the presence of the additional compound, more will be left in an
unbound state.
The amount of free testosterone can be altered
(increased) by the use of aromatase inhibitors (the less
testosterone that is synthesized [aromatized] into estrogen, the
more total testosterone) or inhibitors of the plasma proteins
that bind into testosterone. Manipulating the tendency of a
testosterone to exist in an unbound state is an effective way to
alter the overall activity and potency of one's overall
testosterone levels. Higher levels of testosterone produce an
enhanced anti-glucocorticoid effect, which yields an
anti-catabolic, or more precisely, anti-proteoolytic, effect on
muscle cells. This indirect anabolic effect is the result of
testosterone's high affinity for binding with glucocorticoid
receptors, thus blocking the normal messenger pathway that
triggers protein release from muscle tissue. More free
testosterone also likely results in higher concentrations of
IGF-1 and IGF-1 receptor sites in skeletal muscle tissue.
Correspondingly, lower testosterone also likely yields less
IGF-1 production and a corresponding decrease in IGF-1 receptor
sites. Lower free testosterone also likely means a weaker immune
system.
The Synthesis (Aromatization) of Testosterone to
Estrogen in Males and the Significance of Maintaining Correct
Testosterone to Estrogen Ratios
Although testosterone is
considered to be a male hormone and estrogen a female hormone,
both hormones exist in both males and females and serve
important functions for both. Estrogen is a term that really
represents a collection of female hormones, with esterone
predominating. Since esterone is the estrogen that is normally
in the highest concentration, it is an excellent marker for
basic estrogen levels for that reason. At least three estrogens
have multiple and overlapping functions. Men obtain their
estrogen through the action of the aromatase, which synthesizes
(aromatizes) testosterone into estrogen. However, when
concentrations of estrogen become too high and/or the normal
ratio of testosterone to estrogen decreases, the potential for
the development of undesirable conditions arises. This includes
the development of the female breast tissue (gynecomastia),
increased body fat and water retention. Also, research suggests
that DHT and prostate tissue growth have a direct connection to
above normal estrogen elevations and reduced testosterone
levels.
The ESTROGENEX Mechanism of Action
The ESTROGENEX
proprietary formula was developed by combining naturally
occurring aromatase inhibitors and inhibitors of the action of
SHBG. The primary active ingredients in ESTROGENEX are
Coumesterol and Chrysin. ESTROGENEX does not exert its action
through any direct hormonal or prohormonal activity (androgenic
or estrogenic).
Before ESTROGENEX , little success had been
achieved using chrysin as an effective aromatase inhibitor
because chrysin is poorly absorbed in the bloodstream. However,
in addition to their own specific aromatase inhibiting and
estrogen blocking actions, the proprietary blend of other
ingredients work in synergy with chrysin to maintain a stable
estrogen environment. We also incorporated our proprietary
delivery system called ESTROGENEX to avoid competing with other
hormones such as testosterone in the Aromatase Cytochrome
P450.
It is believed that ESTROGENEX exerts its effects
through several mechanisms of action, which can be classified
into two groups:
as an inhibitor of the aromatase enzyme
responsible for the conversion of testosterone to estrogen and
an inhibitor of the action of SHBG, and
as a blocker of
selective anabolic estrogen receptors and/or inhibitor of
selective estrogen signaling.
Substances that are
aromatase inhibitors block the action of the enzyme aromatase
that converts testosterone to estrogen. Substances that act as
an anti-estrogen are those that block the estrogen receptor.
Thus, even though there is estrogen circulating in the blood,
the estrogen cannot exert its effects because it is blocked from
attaching to its estrogen receptor. The dietary supplement
ESTROGENEX is a multi-pathway agent that exerts its influence by
blocking various stages in the aromatase process and by
inhibiting SHBG's action; an activity not clearly addressed by
any of the aromatase inhibiting or anti-estrogen products.
Further, it appears that use of ESTROGENEX may result in
long-term blocking of selective anabolic estrogen receptors
and/or inhibition of selective estrogen signaling (these
anabolic estrogens are those demonstrating the undesirable
effects associated with breast cancer and gynecomastia). This
activity has not been addressed by any known dietary supplements
or pharmacological agents.
ESTROGENEX as an Elevator of Total
Testosterone and Liberator of Free Testosterone
As a powerful
aromatase inhibitor, ESTROGENEX also possesses notable
testosterone stimulating properties. The aromatase inhibiting
action reduces the signal that estrogen sends to the brain to
suppress endogenous testosterone production (estrogen is a main
feedback signal to control the release of testosterone, thus
increasing the testicular output of testosterone).
ESTROGENEX
thus assists in resetting the body's level of its own natural
testosterone production by regulating the activity of the
hypothalamic-pituitary-testicular axis (HPTA), which constantly
adjusts the body's production of testosterone to maintain target
blood levels. Continued use of ESTROGENEX results in not only a
significant reduction in the production of estrogen, but also a
corresponding substantial increase in endogenous
testosterone.
Only ESTROGENEX addresses all possible channels
to estrogen maintenance and free testosterone elevation, which
means optimal hormonal levels for muscle building, fat loss and
anti-aging support.
Suggested Use: Take 3 tablets daily.
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