What causes pain?
No one completely understands how pain
works. Pain is really something you feel in your brain. For
example, let's say you hit your finger with a hammer. The part
of your finger that is damaged has nerve endings in it. These
are little detectors in your joints and your skin that feel
things like heat, touch, vibrating, and, of course, big crushing
shocks like being hit with a hammer. There are different
receptors for each of these types of sensations. The damaged
tissue in your finger also releases some chemicals that make
those nerve endings register the crushing shock even stronger,
like turning up the volume on your stereo so you can hear it
better. Some of these chemicals are prostaglandins, and working
cells in the damaged tissues make these chemicals using an
enzyme called cyclooxygenase-2 (COX-2).
There have been
chemicals, both natural and synthetic, used for centuries to
treat pain. One of the first and most influential physicians,
Hippocrates, wrote about a bitter powder extracted from willow
bark that could ease aches and pains and reduce fevers as long
ago as the fifth century B.C. The active constituent in willow
bark is known as salacin. This chemical can be converted
(changed) by the body after it is eaten to another chemical,
salicyclic acid.
A German man named Hoffmann had arthritis
and suffered from living in a great deal of pain from a bad
back. His son, German chemist Felix Hoffmann, worked for a
chemical company known as Freidrich Bayer & Co. Felix wanted to
help his father by developing a chemical that would ease his
dad's pain and not irritate the stomach lining. He finished his
studies in 1897 and companies have been trying to duplicate and
improve on this invention ever since.
Pain Management and the
Chemistry Behind It
Pain Rx helps by stopping cells from
making prostaglandins. Remember the enzyme, COX-2? It is a
protein made by your body's cells whose job is to take the
chemicals floating around in your tissues and turn them into
prostaglandins. COX-2 can be found in most normal tissues, but
much more of it is made in tissue that has been damaged in some
way. A recent natural pain management product, called Pain-Rx,
sticks to COX-2 and won't let it do its job; it is like a lock
you put on your bicycle. The bicycle won't move with the lock on
and COX-2 cannot work with Pain-Rx stuck in it. So by taking
Pain-Rx, you do not stop the problem that's causing the
pain-like the hammer damaged finger, but it does lower the
volume on the pain signals getting through your nerves to your
brain. By stopping the prostaglandin production, it has effects
on pain and inflammation. Many of the over-the-counter drugs on
the market today, such as ibuprofen (Motrin® and Advil®), and
naproxen (Aleve® and Naprosyn®), have various side effects that
are undesirable. Although they have various side effects, over
100 billion tablets are consumed annually. This is a staggering
number, if you think about it. This is almost 3 million tablets
per day!
Powerful Prescription Opioid Agonists
Over 100
million prescriptions are written each year for prescription
opioid agonists such as hydrocodone, oxycodone, fentanyl, and
hydromorphone. In fact, hydrocodone with acetaminophen was the
product with the most prescriptions written in 2004, with 92.7
million prescriptions in America alone. The products are
scheduled by the DEA for good reason, as they have a high
potential for abuse. Three drugs in particular have come under
increased scrutiny for their dangers: 1) Oxycontin® is a
powerful opioid agonist that is very powerful and effective if
used as directed. Unfortunately, people have figured out a way
to destroy the product's controlled-release mechanism, causing
all the drugs active components to hit the bloodstream all at
once. Thousands of deaths have been blamed and/or linked to
misuse of Oxycontin®. 2) Hydromorphone (Palladone®), also
marketed by Purdue Pharma L.P., is ten times stronger than
morphine! Palladone® was approved by the FDA on September 24,
2004 for the management of persistent, moderate to severe pain.
On July 13, 2005, the FDA asked Purdue Pharma to pull the
product from the market. The risk cited by the FDA involved a
dosage dump - the sudden release of the full strength of a drug
designed to be absorbed slowly. This can occur if a patient
mixes Palladone ® and alcohol. One drink of alcohol can cause
the sustained-release mechanism to be broken down. Even at its
lowest marketed dose (12 mg) of Palladone®, the consequences
could lead to serious, or even fatal, adverse events. This
product was pulled off the market less than a year after being
approved by the FDA. 3) Fentanyl Patch - The FDA issued a Public
Health Advisory regarding the safe use of transdermal fentanyl
patches in response to 120 deaths in patients using this potent
narcotic medication for pain management. As of the time of this
writing, they do not know if it relates to inappropriate use of
the patch or factors related to the quality of the
product.
These analgesic pain relieving narcotics and opioid
agonists are very effective when used as directed, but
unfortunately they seem to be causing way too many deaths and
addictions to support their continued widespread usage. Hi-Tech
Pharmaceuticals, Inc. in Norcross, GA, and Pharmatech Limited in
Belize recently developed the first natural alternative to OTC
and prescription pain relievers. Pain-Rx mimics the effects of
naturally occurring pain reducing chemicals (endorphins) that
are found in the brain and spinal cord. Pain-Rx blocks the pain
signals in the brain causing the pain to be lessened, if felt at
all. Pain-Rx also works on the prostaglandins, which actually
allow you to feel the pain. They also cause the inflammation to
bathe the tissues in fluid from your blood that will protect the
ailment and help it to heal. Pain-Rx was developed to work
synergistically as a non-addictive opioid agonist and as a COX-2
inhibitor. Its proprietary formula includes:
(1) Paullinia
tomentosa - a plant known to contain tannins effective at
dosages as low as 5 mg of a methanol extract; (2) Chiococca alba
- a plant known to contain coumarins, alkanes, and lignans known
to help alleviate pain with an ethanolic extract from the dried
leaves; (3) Mimosa pudica - the most potent of the three
Belizean plants in this product - has been shown to alleviate
pain, and is also used as an antispasmadic, muscle relaxant, and
anti-inflammatory. This 1:1 ethanol-water extract is very
effective for pain management and is currently patent pending
for pain relief; (4) Lactuca virosa - also known as lettuce
opium due to its mild sedative and analgesic effects. It was
studied some time ago by the council of the Pharmaceutical
Society of Great Britain in 1911. The two main constituents are
Lactucopicrin and Lactucin. Pain-Rx only uses the highest-grade
lactuca virosa grown in Great Britain; (5) White Willow Bark
extract - lowers the body's level of prostaglandins, which
reduces aches, pains, and inflammation. Hi-Tech's proprietary
95% extract has been shown to relieve acute and chronic pain,
control arthritis discomforts, and reduce muscle aches; (6)
Phellodendren Amurense - this amazing herb has been shown to
inhibit COX-2 enzymes. COX-2 enzymes in our bodies are involved
with how we feel and experience pain; (7) Boswellia Serrata -
this herb's active constituent, boswellic acid, has been shown
to exhibit anti-inflammatory activity. Clinical trials have
shown beneficial effects in rheumatoid arthritis
also.
Pain-Rx is unlike any other pain management product on
the market. Pain-Rx combines both the analgesic effect of
natural opioid agonists with natural COX-2 inhibitors. People
who experience minor pain, chronic discomfort, and constant or
frequent muscle pain need to give this amazing product a try.
Pain-Rx is the solution both OTC and prescription pain medicines
have unsuccessfully addressed from a safety and efficacy
standpoint.
Serving Size: 2 Tablets
Proprietary Blend with
Explotab Technology: 600 mg
Paullinia Tomentosa Extract
(leaves), Chiococca Alba Extract (leaves), Mimosa Pudica (whole
plant) Extract, Phellodendron Amurense Extract (bark), Latuca
Virosa Extract (leaves), White Willow 90% Extract (bark),
Tumeric Extract (rhizome), Valerian Extract (root), Boswellia
Extract (resin/gum), Naringen (fruit), 6-7 Dihydroxybergamottin
(fruit), Yerba Mate Extract (leaves).
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General Information and datasheet (HI-TECH PHARMACEUTICALS)
