New Oxybolin by Hi Tech Pharmaceuticals
Oxybolin 250 is a
non-steroidal anabolic agent designed to increase muscle mass
and decrease bodyfat. Oxybolin 250 is an adaptogenic aid that
can help athlete's from over-training by accelerating
recuperative powers. Oxybolin can be used alone or in cojunction
with any bodybuilding stack. Its effects complement other
products and are non-redundant.
Oxybolin by: Dr. Roy Gill
--
Oxybolin 250 is the product every athlete or health
conscious person has been waiting for.
Every now and then, a
supplement comes along that defies the odds. In other words, it
actually works the way its advertisers claim, and at the dosages
recommended on the bottle. This is far from the norm, though. In
my opinion, the only clear-cut, non-steroidal anabolic agent and
ergogenic aid to come out of the 90’s was creatine.
As fate
would have it, I recently received a lot of Soviet translated
research on a water soluable, sugar-like derivative of
cholesterol. According to the data, it is orally active,
effective at low dosages (assuming the proper starting material
is used prior to extraction), non-toxic, and in most people,
exerts noticeable effects in less than 10 days. It’s called
20-Hydroxyecdysone (20-EC), and I can honestly say that this
compound works, if extracted correctly with the other
phytochemicals in Rhaponticum carthamoides.
As a group,
ecdysteroids are naturally occurring, polyhydroxylated plant
sterols that have a plethora of non-hormonal anabolic and
ergogenic activities in the body. Their structure includes three
hexane (6 carbon) rings and one pentane (5 carbon) rings. The
most biologically active form of the ecdysteroids is thought to
be 20-EC and turkesterone, both of which are harvested from
Rhaponticum carthamoides. Extracts of this potent plant have
been approved by the Ministry of Public Health in the former
Soviet Union over 20 years ago to be used for “raising the
mental and physical working ability” as a pharmacological
preparation.
Introduction
Rhaponticum carthamoides
(Willd.) Iljin, syn. Leuzea carthamoides (Willd.) DC, is a large
perennial herb in the compositae family. Rhaponticum
carthamoides has a wood-like horizontal rhizome, multiple long,
hard roots, and is capable of growing to a height of over six
feet. Rhaponticum carthamoides grows in the pristine alpine and
subalpine zones, and alpine meadows of Southern Siberia. The
roots and rhizomes are the medicinal parts, with the biological
activity determined by phytoecdystone quantity, including
ecdysterone.
This herb is a hidden jewel. Rhaponticum
carthamoides extract (RCE) has demonstrated a normalizing effect
on the central nervous and cardiovascular systems. RCE improves
sleep, appetite, mood, mental and physical state, and the
functional ability of humans under working conditions. It is a
classic adaptogen, possessing a wide spectrum of anabolic
activities, acting on the contractile proteins of the skeletal
muscles, as well as on other areas of the body, including the
liver, heart, kidneys, and brain. It builds lean muscle, reduces
body fat, improves work and/or athletic performance, improves
mental acuity, relieves depression, is a tonic for the vital
organ systems, is reliable blood-building tonic, and delays the
effects of aging. It is useful for both andropause and
menopause.
Chemistry
The principal constituents of the
whole plant are ecdysteroids (5-beta-cholest-6-on-7-ene
derivatives) and flavonoids. Also polyacetylenes and triterpenes
have been isolated from different parts of the plant (Girault
et. al. 1984, Szendrei et. al. 1984, Varga et al. 1986 and
1990). Of the isolated compounds, only 20-hydroxyecdysone and
Turkesterone are currently considered to play an important role
in the action of this plant. (Syrov and Kurmukov 1976). The main
flavonoides are 6-methoxy-kampferol, patuletin,
isorhamnetin-glycoside and quercetin-5-glycoside. All leaf and
root samples contained 20-hydroxyecdysone as a main compound of
Rhaponticum carthamoides. The 20-hydroxyecdysone of the roots
ranged from 0.7% to 2.0% being higher than that of the
leaves.
The 20-hydroxyecdysone content of the leaves ranged
between 0.006 and 0.10%. According to the quantitative and
qualitative data obtained experimentally, the optimum time for
root harvest of Rhaponticum carthamoides is at the end of August
when the 20-hydroxyecdysone content is the highest.
The
research on the effects of Rhaponticum carthamoides has been
done for the last 60 years on the whole plant extract with
20-Hydroxyecdysone and turkesterone being the principal active
compounds. Ingested ecdysteroids survive exposure to gastric
acid and are rapidly absorbed into the enteric blood vessels.
Excretion is primarily via the liver. More recent research has
identified 8 ecdysterones, and has confirmed synergy in their
combined usage (Baltaev and Abubakirov 1987; Gorovits et al
1974; 1977). When using a powdered extract of Rhaponticum
carthamoides ensure that it is standardized to 50-65%
20-Hydroxyecdysterone. This will ensure that the extract
possesses an effective amount of 20-EC and with a natural
extraction process it should yield between 75% and 100% total
Ecdysones or ecdysteroids. When properly extracted, Rhaponticum
carthamoides should have 2 parts 20-Hydroxyecdysterone to 1 part
total ecdysones or ecdysteroids. Rhaponticum carthamoides
contains a number of other biologically active compounds
believed to act in harmony with ecdysterones, imparting its
unique adaptogenic qualities (Azizov and Seifulla 1998). It is
rich in flavanoids, sesquiterpene lactones, and polyines
(Opletal et al 1997).
Therapeutic Activity
In 1961
Rhaponticum carthamoides liquid extract (1:1) was officially
recognized and included in the Soviet Pharmacopoeia as a natural
remedy for overcoming fatigue, improving physical and mental
productivity performance, and for shortening recovery time after
illness. Over the years, RCE has been reported to have numerous
pharmacological effects in humans and laboratory animals
(Kokoska et al 2002; Kolmakova and Kutolina
1966).
Adaptogenic Activity
RCE has pronounced adaptogenic
effects. It increases dynamic work capacity, improves stress
response and adaptability to physical and mental challenges, and
enhances mental and physical capacity for work under unfavorable
conditions. It has a fundamentally different mechanism of action
than anabolic steroids in that it does not cause the androgenic,
thymolytic or antigonadotropic effects associated with anabolic
steroid
use. During intense muscular activity, RCE inhibits
disorders of energetic metabolism, maintains stable glycogen
levels in the skeletal muscles, increases the blood supply to
the muscles and brain, and shortens the recovery period after
prolonged muscular workloads. Animals given RCE and subjected
experimentally to extreme stressors (a wide range of physical,
chemical and biological factors) as part of screening techniques
for adaptogenic plants, were found to have increased resistance
to the adverse influence of various chemical stressors. RCE
normalizes adrenal health (weight) and other endocrine glands
during and after prolonged periods of stress. Administration of
RCE improved cold temperature adaptation in men working in a
Nordic climate (Galambosi et al 1997).
Oxybolin 250 can be
used by:
Anyone who wants to build muscle and/or enhance
athletic performance.
Any bodybuilder/ athlete already using
anabolic steroids, HGH, and/or creatine supplements who wants to
promote muscle growth.
Anyone who wants a supplement that
will complement (rather than be redundant to) his or her current
athletic supplement stack.
Athletes who are avoiding androgen
supplements (e.g., women), but still want to promote muscle
growth.
Athletic Enhancement and Recovery, including
Metabolic Effects
Studies conducted at the National Research
Institute of Sports in Moscow, Russia have confirmed that the
use of RCE by trained athletes improves endurance, speed,
recovery and other physiological parameters. Based on in-depth
studies, Russian scientists, researchers, and trainers recommend
RCE in many areas of athletics. Since it actively influences
metabolic processes RCE is effective for preventing and
eliminating myocardial tension associated with exercise.
Laboratory studies have shown the anabolic affects of RCE,
including the capacity to increase body weight by improving the
muscle-fat ration, to increase hemoglobin and erythrocyte
levels, to raise the total level of protein content in the
blood, and to reduce the build-up of uric acid. The proven net
result of this nutrient is that the body’s muscle building
processes outpace the muscle breakdown processes, leading to
greater fitness, endurance and performance (Saratikov 1949;
Cherdyntsev 1970; Salnik 1970; Demin et al 1976; Syrov and
Kurmokov 1976; Gerasyuta and Koval 1981a; Lupandin 1991;
Seifulla et al 1993; Gadzhieva et al 1995; Logvinov and
Pugachenko 2001). During intense muscular activity, RCE
maintains a stable level of glycogen and phosphates in the
skeletal muscles, increasing the blood supply to the muscles and
brain. It shortens the recovery period after prolonged muscular
workloads, estimated by normalizing of cardiovascular parameters
(Cherdyntsev 1970; Salnik 1970). Demin et al. (1976) reported a
significant increase in physical performance – strength,
endurance and coordination in top-level athletes after taking
RCE. Seifula et al. (1993) demonstrated that the RCE in
combination with carnitine increased the maximum running speed
and endurance (Demin et al 1976; Seifulla et al 1993). According
to V. Petkov et al. (1984) RCE considerably increases the
working capacity of tired skeletal muscles and increases the
concentration of glycogen, ATP and creatine phosphate (Petkov et
al 1984). The intense physical activity of high-class athletes
leads to an increase in blood coagulation, which causes soreness
of the muscles and often results in injuries. A comparative
study was conducted using an extract blend of RCE and
Eleutherococcus senticosus in combination with vitamins. A
20-day course produced a decrease in the blood clotting and
blood coagulation factors induced by intensive athletic
training. Treatment with this new combination adaptogenic
product caused a marked reduction in the coagulation potential
in athletes, accompanied by increased work capacity and recovery
after intensive training (Azizov 1997). In another experiment
with athletes it was found that the same “polyadaptogens”
provide significant antioxidant effect (Azizov and Seifulla
1998). Studies at the Russian National Sports Research Institute
revealed that RCE and several RCE based products possess a broad
spectrum of anabolic actions. Leading sport pharmacologist S.N.
Portugalov with a group of his associates have demonstrated that
RCE possesses a significant anabolic activity and when used by
top level athletes (middle and long distance runners) it can
prevent them from losing lean muscle tissue during the time of
intensive training enhancing their sport performance
(Pourtugalov et al 1994; Gadzhieva et al 1995).
In one study
a natural protein substance known to favorably influence the
muscle-fat ratio, as well as work capacity among athletes, was
used in combination with RCE and compared to placebo (Lupandin
1991). In the combined study it was found that taking RCE
combined with additional supplemental protein was optimal to
achieve the highest increase in work capacity in athletes. Of
the athletes who consumed just protein, only a slight increase
in muscle mass was observed. Those who used a placebo lost a
slight amount of lean muscle, while those who used protein plus
ecdysterone showed a 6-7% increase in lean muscle tissue with
nearly a 10% reduction in fat. No difference in hormonal
parameters in those taking RCE was observed during the study
period.
RCE was tested on the human body by caliperometric
measurements of body folds. RCE taken orally for three weeks
diminished body fat and increased lean muscle content under
conditions of daily aerobic-anaerobic training. RCE increased
the muscle mass, as well as the magnitude of “total work” (Syrov
and Kurmukov 1976). In an experiment with 112 athletes, 89
percent of those receiving RCE displayed a more rapid passing of
fatigue, less apathy after physical work, and improved
performance in sports, such as track and field athletics,
swimming, speed skating and ski racing. The speed and strength
qualities of the tested athletes were all significantly improved
in comparison with the control group that received a placebo.
After taking RCE, 69 percent of the subjects displayed
accelerated adaptation to climatic and social conditions, 86
percent displayed an improved appetite, and 78 percent
registered a significant increase in adaptation to intense
physical workloads. Additionally, a comparison experiment was
conducted with commonly known anabolic steroids. The effects of
RCE were comparable to that of the steroid compounds, yet RCE
had none of the negative affects on the function of the adrenal
cortex. The androgenic effects of anabolic steroids and their
accompanying side effects were not revealed in the RCE (Lupandin
1991).
Anti-diabetic/ Insulintrophic
In a study of people
with diabetes, who were treated with a combination of
Eleutherococcus, Rhaponticum, and Rhodiola extracts, impressive
improvements in the normalization of blood glucose levels were
shown (Kolmakova and Kutolinam 1966).
Increased protein
synthesis
Introduction of ecdysterone, (0.5 mg/ 100 g), from
RCE, to rats for 7 days was accompanied by accelerated body
weight gain and also by a rising weight of the liver, heart, and
kidneys. In these organs the total amount of protein increases
(Seifulla et al 1993). Studies conducted in seven clinics in
Moscow, Kiev, and Leningrad revealed that RCE significantly
improves the physical and mental state of patients; increases
work capacity and increases body weight during conditions of
decreased nourishment caused by protein synthesis disorders. Its
anabolic properties cause a normalization of body weight with no
negative influences noted on the functions of either the adrenal
cortex or the endocrine glands (Antoshechkin 2000). RCE
specifically helps prevent the catabolic state seen with stress.
Components of the plant have shown anabolic properties in
clinical studies. Under conditions of daily aerobic and
anaerobic training, patients who consumed RCE for three weeks
lost fat and gained muscle mass (Syrov et al
1997).
Pharmacology
Rhaponticum carthamoides considerably
increases the capacity of tired skeletal muscles, and
contributes to a more sparing use of carbohydrates and an
enhanced new synthesis of glycogen and high-energy phosphorus
compounds (Salnik 1967). When given to athletes, its extract is
claimed to increase endurance, reflexes and concentration, while
the athletes grew tired later and recovered earlier (Saratikov
1966). The rhizomes and roots of Rhaponticum carthamoides are
officially listed in the Russian Pharmacopoeia. The fluid
extract and the crude ecdysteroid fraction obtained from the
roots are used in the production of Ecdysten tablets, which are
used in the official medicine in Russia. Also other preparations
made from these are marketed in a number of
countries.
Turkesterone
Turkesterone is contained in
Rhaponticum extracts at a greater than 25% when extracted
properly. Dr. Zakir Ramazonov, a world-renowned scientist,
believes turkesterone to be the most potent ecdysteroid.
Unfortunately, most extracts on the market today are void of the
“full spectrum” of ecdysteroids, including
Turkesterone.
Mechanism of Action
In contrast to
anabolic-androgenic steroids that exert their effects
hormonally, 20-EC and turkesterone appear to have several
different mechanisms of action. In a nutshell, they appear to
act as potent “adaptogenic” compounds, enabling athletes to
increase their workloads, improve recovery and stimulate gains
in strength and stamina during periods of intense physical
activity. In other words, they appear to promote a “super
training” effect.
Typically, purported wonder supplements
like this one are teased out of research from other species and/
or from trauma patients, which can be quite different from the
typical trainee. Not so with ecdysterone. During the past 20
years, at least seven different Eastern Bloc scientific teams
have completed comprehensive research studies on 20-EC. As a
result of this research, data have been collected on mice, rats,
cats, birds, cattle, and yes, humans – top level male and female
athletes, to be exact.
The most intriguing part about 20-EC
is that despite its wide spectrum of biologic activities, the
benefits seem to occur without causing androgenic (body hair,
male pattern baldness, etc.) or anti-gonadotrophic
(testicle-shrinking) side effects. This is not totally
unexpected considering that 20-EC does not appear to bind to
androgen or estrogen receptors. Therefore, men can use it
without risk of developing gynecomastia (“bitch tits”), and
women can apparently use it without risk of
masculinization.
In fact, the safety of 20-EC is unquestioned
in Eastern literature, even at doses much higher than the 30-50
mg/day necessary to induce anabolic and ergogenic effects. As
far as we are aware, not a single athlete in any research study
to date reported having subjective side effects during
supplementation with 20-EC. There were also no objective changes
in blood work routinely used to assess side effects (i.e.,
resting hormone levels, blood lipids or tissue [liver]
enzymes).
At this point, some of the more suspicious readers
are probably asking the million-dollar question: What’s the
difference (if any) between all the 20-EC products on the
market? Very simply put – quality. You see, to extract 20-EC
from Russian Rhaponticum is an expensive proposition; it costs
about $2,500 a kilogram to do it right. This explains why
knock-off products using inferior material (typically derived
from Chinese sources) are widespread. There are even companies
using Chinese 20-EC that reference the Russian data in their
advertisements. Misleading? It is in my book. And the reason is
simple: to enhance their profit margin (Chinese 20-EC is only
several hundred dollars per kilo).
The difference in the
quality of Rhaponticum extracts is enormous! As a matter of fact
many people have tried ecdysterone products in the past and it
did not work at all. Today Authertic Rhaponticum extracts that
include turkesterone and 20-Hydroxyecdysterone exhibit sales
that are largely from repeat buyers – which shows it works. Only
products on the market that contain active fractions of both
20-Hydroxyecdysterone and turkesterone – the latter of which may
prove to be the most anabolic – appear advantageous.
Editors
Note: Hi-Tech’s Oxybolin 250 appears to be the only ecdysteroid
product to currently contain actual turkesterone with active
fractions of 20-Hydroxyecdysterone as well. It is standardized
to 250 mg Rhaponticum carthamoides extract per tablet with a
“full spectrum” of total ecdysteroids. It is standardized to
contain: 165 mg 20-Hydroxyecdysterone – 10 mg turkesterone – 70
mg broad-spectrum ecdysteroids. This yield is 98% pure
Rhaponticum carthamoides extract in Oxybolin 250.
Although
Oxybolin 250 by Hi-Tech Pharmaceuticals, Inc. appears to be the
first product of its kind, you can expect many copycats in the
near future. Do not be fooled. Oxybolin 250 ’s release is great
news for anyone wanting to increase lean muscle mass, decrease
fat and improve performance. So bodybuilders, fitness
enthusiasts, and athletes pay attention, the muscle-building
breakthrough of the 21st century is here and the results being
achieved by Oxybolin 250 has been phenomenal. Oxybolin 250 works
to create the “perfect” muscle-building environment in the body,
among other positive effects. The perfect conditions for
creating the perfect muscle building environment include
maintaining a positive nitrogen balance and increasing protein
synthesis along with intelligent, consistent exercise and a
balanced diet rich in protein. It’s long been understood that if
the body was able to maintain the perfect anabolic environment,
maximum muscle growth would occur. Oxybolin 250ä enhances the
rate of protein synthesis while simultaneously showing no side
effects. Now with the release of Oxybolin 250 these amazing
results can be achieved. I conducted a study to determine the
effect of Oxybolin 250 on muscle tissue mass and fat mass, while
testing for hormonal changes in the subjects. For the study,
three control factors were used: a placebo, protein, and
Oxybolin 250 with protein. The results were significantly in
favor of the third factor. Of the 50 highly trained male and 10
female athletes who consumed Oxybolin 250 and protein showed an
8% increase in lean muscle tissue with a 9.8% reduction in fat!
This was achieved in only 30 days. Safety testing was conducted
during the same period which showed no difference in hormonal
balance. If Oxybolin 250 can do this for highly trained
athletes, just think what it can do for the average
person!
Oxybolin 250 also contains a proprietary blend of
6-Keto Diosgenin, Beta-Sitosterol, 7-Keto Diosgenin, 6,7
Dihydroxybergamottin and Naringen for additional benefits. These
compounds act to work synergistically with Rhaponticum
carthamoides extract. The wild yam yields natural steroid
alkaloids called “diosgenins” that are virtually identical to
synthetic chemical structures of several prescription steroids
formulated years ago. And, because these steroidal alkaloids are
completely natural, they can be further “tweaked” to exert an
even stronger anabolic effect. This is what has been done when
forming 6-Keto and 7-Keto Diosgenin. Beta-Sitosterol is a plant
sterol that can increase the levels of natural testosterone
without added estrogenic and androgenic side effects. This
product may also have anabolic activity on its own and has
proven to have many health benefits like assisting in lowering
cholesterol and protecting the hair and prostate from conversion
of testosterone to DHT. Lastly, Extend-Rx™ has been incorporated
to extend the half-life of all the substances and ensure first
pass through the liver does not deactivate these compounds. Many
pro-hormones, testosterone, and oral plant sterols have poor
oral absorption, and have a very short (20-60 minute) duration
of action. Extend-Rx allows “safe passage” to the bloodstream,
as well as, prolongs the time in which the plant steroids remain
active in the body. Oxybolin 250 works by a different mechanism
than other bodybuilding supplements (such as androgens,
creatine, HGH, and protein), so it can also be complementary to
an athletic supplement stack rather than redundant.
Oxybolin
250 can be used by:
Anyone who wants to build muscle and/or
enhance athletic performance.
Any bodybuilder/ athlete
already using anabolic steroids, HGH, and/or creatine
supplements who wants to promote muscle growth.
Anyone who
wants a supplement that will complement (rather than be
redundant to) his or her current athletic supplement
stack.
Athletes who are avoiding androgen supplements (e.g.,
women), but still want to promote muscle growth.
|
