RELEVANT RESEARCH
LEANFIRE™ Keeps your metabolism optimized
even when operating on reduced calories, and increases energy
levels to support an active and healthy lifestyle.
Because
INSTONE™ is committed to bringing you the best that nutritional
science has to offer, we have compiled research and information
indicating that LEANFIRE™ is truly best in class.
HOW IT
WORKS
LEANFIRE™ works by keeping your metabolism ramped up
to burn fat as well as increasing your energy and stamina.
LEANFIRE™ also works to optimize thyroid and metabolic activity
to burn fat, and contains ingredients to maximize endurance,
focus, and combat stress.
As such, LEANFIRE™ is an optimal
product to help you lose weight and gain the energy that you are
looking for. It is a perfect addition to your diet/exercise
regimen and will definitely jump start your
program!
Research has shown that the potent adrenal
steroid DHEA has profound physiological impacts including
heightened thermogenesis, decreases in body weight gain, and
decreased incidence of obesity in animals 1.
7-Keto™, a
metabolite or derivative of DHEA - a primary ingredient in
LEANFIRE™ - has also been shown to have similar significant
physical effects.
More specifically, 7-Keto™ has been shown
to increase key enzymes related to thermogenesis to an even
greater extent than its parent DHEA 2,3. Studies have also shown
that 7-Keto™ is related to decreases in body weight and
significant reductions in body fat 4.
7-Keto™ is included as
a key ingredient in LEANFIRE™ . As such, LEANFIRE™ , is a
superior way to ramp up the body’s metabolism and activate key
fat-burning enzymes! Whether you goal to accelerate fat loss or
prevent “diet-induced” metabolic decline, LEANFIRE™ is an
effective way to get the results you desire.
7-Keto™ is the
registered trademark of Humanetics Corp.
EVOLEAN™
E and Z
GUGGULSTERONES
Guggulsterones, key ingredients in LEANFIRE™
, support the conversion of peripheral, inactive thyroid hormone
(T4) into active thyroid hormone (T3). T3 is the chemical
messenger that governs metabolic rate, or how much energy the
cells of our bodies use day to day.
By increasing T3
overall, the effect is an increased metabolic need for energy.
This metabolic support increases the body’s ability to burn fat
for fuel.
Specifically, LEANFIRE™ contains 95% pure E and Z
guggulsterones. These are strains of the herbal derivative that
have been shown to have this metabolic effect. As such,
LEANFIRE™ is a superior way to optimize thyroid activity to
promote significant fat loss.
EVODIAMINE
Evodiamine is
an alkaloid found in the herb Wu-Chu-Yu. It demonstrates
thermoregulatory, analgesic, and cardiovascular effects, and is
included in LEANFIRE™ as a primary ingredient. It has been
related to the promotion of weight loss, fat breakdown,
increased blood flow, and the promotion of oxygen use.
Included in LEANFIRE™ , Evodiamine is an exciting new compound
that accelerates fat-loss by increasing your body’s core
temperature !
RHODIOLA
Rhodiola rosea, a key ingredient
in LEANFIRE™ is a plant or herb also known as “golden root” or
“rose root.” This potent plant has been incorporated as part of
traditional and folk medicinal practices for many years.
Typically, Rhodiola was used to combat stress to the body
system. It was used as a method to increase endurance, combat
fatigue, treat depression, and promote longevity5. It has been
shown to stimulate the recovery process after intense exercise
and increase energy recovery as well6. Rhodiola rosea has also
been found to have a large neural effect - resulting in
decreased “sluggishness” and increased mental energy, attention,
and feelings of well being7.
As such, it is included in
LEANFIRE™ because of these potent effects. This ingredient makes
LEANFIRE™ an optimal method to increase one’s energy and
stamina, as well as combat oxidative stress during intense
exercise!
GREEN TEA AIDS IN FAT LOSS
Green tea
components are included in INSTONE™’s LEANFIRE™, making it a
phenomenal fat-loss aid! Anti-obesity effects of components of
green tea were investigated by researchers in Japan recently8.
This study focused on examining several primary components in
green tea. Researchers were interested in how these components
aided in green tea’s presumed fat-loss properties. Diets
containing powder made from green tea and corresponding singular
components of green tea – catechins, caffeine, and theanine –
were fed to laboratory mice. Each mouse received a diet
containing 2% green tea powder or respective components of green
tea based on this 2% powder level for 16 weeks.
At the end
of the 16 week trial, body weight, adipose tissue, serum lipid
levels, as well as liver lipid levels were measured. Results
indicated that body weight and fat tissue were lowered in mice
that were fed green tea powder, as well as caffeine and theanine
separately. When caffeine was examined in conjunction with
catechins from green tea, theanine, and both catechins and
theanine, similar significant fat and weight loss was evident.
Specifically, those mice fed caffeine and green tea catechins
combined experienced over 76% decreased weight relative to a
control group. Serum concentrations and non-esterified fatty
acids were also found to be lowered with diets including green
tea, catechins, and theanine powder.
As such, it is
suggested that green tea and components in green tea have
significant anti-obesity effects – specifically body weight loss
and fat accumulation decreases. In addition, green tea catechins
and caffeine were found to have synergistic effects that aid in
these same anti-obesity effects.
As can be seen, Green tea
components included in INSTONE™’s LEANFIRE™, make it a
phenomenal fat-loss aid!
References
1Tagliaferro, A.R.,
Davis , J.R., Truchon, S., and van Hamont, N. Journal of
Nutrition, 1986; 116: 1977-1983.
2Lardy, H, Partridge, B,
Kneer N, and Wei, Y. Ergosteroids: Induction of thermogenic
enzymes in liver of rats treated with steroids derived from
dehydroepiandrosterone. Proc. Natl. Acad. Sci. USA, 1995; 92:
6617-6619.
3Lardy, H, Kneer, N, Wei, Y, Partridge, B, and
Marwah, P. Ergosteroids II: Biologically active metabolites and
synthetic derivatives of dehydroepiandrosterone. Steroids 1998;
63: 158-165.
4Kalman, DS, Colker, CM, Swain, MA, Torina, GC,
and Shi, Q. A randomized, double-blind, placebo-controlled study
of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight
adults, Current Therapeutic Research, 2000; 61(7).
5Brown R.
Rhodiola rosea A Phytomedicinal Overview, 2002; 56: 40-52.
6Bogatova R, et al. Evaluation of the Effect of a Single Dose of
a Phytoadaptogen on the Working Capacity of Human Subjects
During Prolonged Isolation. 1997; 31(4): 51-54.
7Ramazanov
Z. Rhodiola Rosea The Premier Adaptogen for Mental and Physical
Health. 2003.
8Zheng G, Sayama K, Okubo T, Juneja LR, Oguni
I. Anti-obesity effects of three major components of green tea,
catechins, caffeine and theanine, in mice. In Vivo. 2004
Jan-Feb;18(1):55-62.
Kao YH, Modulation of obesity by a
green tea extract catechin. Am J Clin Nutr. 2000;72: 1232-41.
Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal
caffeine consumption: influence on thermogenesis and daily
energy expenditure in lean and postobese human volunteers. Am J
Clin Nutr. 1989 Jan;49(1):44-50.
Acheson KJ, Maarkiewic B,
Pittet P,. Caffeine and coffee: their influence on metabolic
rate and substrate utilization in normal weight and obese
individuals. Am J Clin Nutr. 33: May 1980 989-997.
Douglas
S. Kalman, Carlon M. Colker, Melissa A. Swain, Georgeann C.
Torina, and Qiuhu Shi, A Randomized, Double-Blind, Placebo
Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in
Healthy Overweight Adults
C Colker, M.D, G Torina, M Swain,
D Kalman. Department of Medicine, Greenwich Hospital, Peak
Wellness, Inc, Greenwich, CT 06830 Double-Blind,
Placebo-Controlled, Randomized Clinical Trial Evaluating the
Effects of Exercise Plus 3-Acetyl-7-oxo-dehydroepiandrosterone
on Body Composition and the Endocrine System in Overweight
Adults
Marwah P, et al. Ergosteroids IV: Synthesis and
Biological Activity of Steroid Glucuronoids, Ethers and
Alkylcarbonates. Steroids 2001; 66: 581-595.
Quinlan PT,
Lane J, Moore KL, Aspen J, Rycroft JA, O'Brien DC. The acute
physiological and mood effects of tea and coffee: the role of
caffeine level. Pharmacol Biochem Behav. 2000 May;66(1):19-28
Nehlig A, Daval JL, Debry G.Caffeine and the central nervous
system: mechanisms of action, biochemical, metabolic and
psychostimulant effects. Brain Res Brain Res Rev. 1992
May-Aug;17(2):139-70
Liao S. The Medicinal Action of
Androgens and Green Tea Epigallocatechin Gallate. HKMJ 2001;
7(4): 369-374.
Poehlman ET. LaChance P, The effect of prior
exercise and caffeine ingestin on metabolic rate and hormones in
young adult males. Can J Physiol. Pharmacol. Vol 67, 1989
Graham TE, Spriet LL. Performance and metabolic responses to a
high caffeine dose during prolonged exercise. J Appl Physiol.
1991 Dec;71(6):2292-8.
Bell Dg, McLellan TM, Exercise
Endurance 1, 3 and 6 h after caffeine ingestion in caffeine
users and nonusers. J Apply Physiol. 2002 Oct;93(4):1227-34.
Musa A, et al. Effect of Rhodiola rosea and Rhodiola crenulata
root extracts on ATP content in Muscle Mitochondria.
Experimental Biology and Medicine. 2003; 136 (12) 664-666.
Baranov V.M. Experimental Trials of Herbal Adaptogen Effect on
the Quality of Operator Activity, Mental and Professional
Working Capacity. 1994; 2-40.
FREQUENTLY ASKED QUESTIONS
Is LEANFIRE™ for losing weight only, or will it give me energy
and a “kick?”
LEANFIRE™ is two products rolled into one.
LEANFIRE™ will optimize your metabolism when your body is
operating on reduced calories. LEANFIRE™ also contains
ingredients that will give you the energy and endurance to get
you through your active and demanding lifestyle.
Are there
any stimulants in LEANFIRE™ that will give me jitters or keep me
up at night?
Each LEANFIRE™ capsule contains as much
caffeine as a cup of coffee. Caffeine sensitive individuals
should start off by taking 1-2 capsules per day and gradually
increase the serving size.
How many times a day can I take
LEANFIRE™?
The recommended serving size is 1-3 capsules
twice daily (6 capsules/day max).
How long will it take
before I see results?
You will begin to feel the thermogenic
and sustained energy within an hour. LEANFIRE™ is a great aid
for weight loss, when coupled with proper diet and exercise
regimen.
Does LEANFIRE™ increase fat metabolism?
Yes –
Evodiamine is an alkaloid found in the herb Wu-Chu-Yu. It
demonstrates thermoregulatory, analgesic, and cardiovascular
effects, and is included in LEANFIRE™ as a primary ingredient.
It has been related to the promotion of weight loss, fat
breakdown, increased blood flow, and the promotion of oxygen
use.
Included in LEANFIRE™ , Evodiamine is an exciting new
compound that accelerates fat-loss by increasing your body’s
core temperature !
Should I take LEANFIRE™ on an empty
stomach, or can I take it with food?
LEANFIRE™ can be taken
on an empty stomach or with food.
What is the standard
recommended dose for men? For women?
Directions for Men:
Begin by taking 1-2 capsules twice daily before a meal and/or
exercise. Gradually increase serving size to 3 capsules twice
daily. Do not exceed the recommended serving size.
Directions for Women:
Begin by taking 1 capsule twice daily
before a meal and/or exercise. Gradually increase serving size
to 2-3 capsules twice daily. Do not exceed the recommended
serving size.
The recommended dosage of this product
contains about as much caffeine as a cup of coffee. Limit the
use of caffeine-containing medications, foods, or beverages
while taking this product because too much caffeine may cause
nervousness, irritability, sleeplessness, and occasionally,
rapid heart beat.
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General Information and datasheet (INSTONE)
