Scivation LipidFX - Makes Losing Fat Easy
By: Derek Charlebois,
Chuck Rudolph and Marc Lobliner—Team Scivation
As anyone who
has ever dieted for an extended period time can tell you, the
hardest part about dieting is controlling your appetite. There
are products on the market today that aim to decrease appetite,
such as hoodia, but for most these simply do not work well
enough. Losing weight is governed by calories in vs. calories
out. If you eat more calories than you burn you are not going to
lose weight.
In addition to controlling one’s appetite,
bodybuilders and fitness enthusiast must worry about preserving
muscle tissue and losing only fat. Nobody wants to work hard to
gain muscle only to lose it when dieting to lose weight.
After extensive research, Scivation has created Lipid FX, a
supplement that activates PPARalpha causing an increase in fat
oxidation, along with decreasing appetite and improving insulin
sensitivity. LipidFX is comprised of three fatty acids:
Oleoylethanolamide, Stearoylethanolamide, TetradecylThioacetic
Acid as well as EGCG. These ingredients have been shown to help:
Maximize Fat Burn*
Support Appetite Control*
Promote
Optimal Cardiovascular Health*
LipidFX—The Future in Fat Loss
Has Arrived!
Scivation LipidFX™ is a precise, scientifically
advanced blend of Lipolytic Lipids™. Lipolytic Lipids™ are fatty
acids that can increase metabolic rate, significantly support
appetite control and immune health, help support healthy lipid
profiles and insulin levels and promote optimal cardiovascular
health. LipidFX™ can also help the body burn fat instead of
muscle while in a calorie-deficient state. Here is why LipidFX
is perhaps the biggest breakthrough in healthy fat loss to
date!
Peroxisome Proliferator-Activated Receptors
(PPAR)
The Peroxisome Proliferator-Activated Receptors (PPAR)
receptor family is divided into three subgroups: alpha,
delta/beta, and gamma. PPARalpha is highly expressed in muscle,
the liver, kidneys, and heart and is involved in the regulation
of lipid metabolism, specifically the transcription of the genes
involved in the beta-oxidation (burning) of fatty acids and
lipogenesis (storage of fatty acids).
Fat can be oxidized in
the mitochondria and the peroxisomes of cells, the majority of
this oxidation occurring in skeletal muscle cells and the liver.
PPARalpha activation increases fat oxidation in mitochondria and
peroxisomes by increasing the expression of enzymes involved in
beta-oxidation of fatty acids [6]. In addition to this,
PPARalpha activation increases the number of both peroxisomes
and mitochondria. The combination of the increased number of
peroxisomes and mitochondria plus the elevation in
beta-oxidation of fatty acids increases the rate and capacity at
which fat can be burned. The end result is more fat loss.
Activation of PPARalpha would be very beneficial for any
bodybuilder or fitness enthusiast looking to lose fat or watch
their weight.
PhosphoLean™: Oleoylethanolamide (OEA) and
EGCG
Oleoylethanolamide (OEA) is an endogenous lipid being
investigated as a potential anti-obesity drug. OEA is
synthesized in the intestines. Its synthesis is increased with
food intake and decreased with fasting. OEA has been shown to
have anorexic properties, meaning it decreases food intake. A
study done on rats showed that OEA’s ability to decrease
appetite did not change plasma levels of various intestinal
hormones involved in satiety, such as ghrelin and CCK, showing
OEA works independently of these hormones [1].
OEA is also
an activator of the Peroxisome Proliferator-Activator Receptor
Alpha (PPARalpha) [2]. Activation of PPARalpha by OEA will cause
an increase in fat oxidation along with a decrease in fat
storage, creating an ideal environment for fat loss. OEA’s
ability to decrease appetite and regulate body weight is
accomplished by the activation of PPARalpha [5]. Standard OEA
has very poor bioavailability so Scivation uses Phospholean, a
form of OEA that is protected from destruction in the stomach.
Green tea extract (EGCG) has been a popular supplement for a
while, but more and more research is confirming not only its
many health benefits, but its ability to promote fat loss. In
addition to multiple animal studies showing green tea to lead to
fat loss published just this year, a three month double-blind,
placebo controlled study on thirty men was published in the
January 2005 issue of the American Journal of Clinical
Nutrition. Compared to the placebo group, those who ingested
catechins (the beneficial compounds in green tea that extracts
are standardized for) daily lost more weight and more fat. While
the earlier research was more preliminary, this study confirms
the ability of green tea to lead to fat loss in
humans.
Recent research has also given us a better picture of
how green tea leads to fat loss. The more well-known mechanisms
are catechol-O-methyl-transferase (COMT) inhibition, decreased
dietary fat absorption, and increased levels of some hormones
that suppress the appetite. A study published last year
suggested yet another mechanism: when given to rats, green tea
decreased the activity of glucose transporter 4 (GLUT4) in fat
tissue, while increasing GLUT4 activity in muscle tissue. What
this means is that fuel was being shunted away from fat and
towards muscle. Not only does green tea facilitate weight loss,
it can also lead to the preferential loss of fat over muscle.
This is a great asset, since maintaining muscle mass is one of
the hardest things to do on a diet.
A new study has
discovered the phytochemicals in green tea are better used by
the body in supplemental form rather than from actual green tea.
The main catechin responsible for the thermogenic effect of
green tea extract is epigallocatechin gallate (EGCG). Studies
show it can increase metabolism by about 4%. That equates to
more than 100 extra calories burned per day for most males. EGCG
inhibits the enzyme responsible for the degradation of NE. By
preventing NE breakdown, its fat burning effect is stronger and
lasts longer.
Stearoylethanolamide
(SEA)
Stearoylethanolamide (SEA) has been shown to decrease
food intake independent of PPAR and without changing
hematochemical parameters such as glucose and triglyceride
levels or leptin (a hormone involved with satiety) expression
[3]. The appetite decreasing effect of SEA was associated with a
reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA
expression. SCD-1 is the rate-limiting enzyme in the
biosynthesis of monounsaturated fats and its reduction is
believed to lead to increased fatty acid oxidation and decreased
lipogenesis in skeletal muscle and the liver [4].
TetradecylThioacetic Acid (TTA)
TetradecylThioacetic Acid
(TTA) is another PPARalpha activator [7]. TTA works in
conjunction with OEA in increasing the oxidation of fatty acids
and decreasing the storage of fatty acids. TTA has been shown to
increase insulin sensitivity by increasing hepatic fat oxidation
and ketogenesis while draining fatty acids from the blood and
extrahepatic tissues. Increased insulin sensitivity means less
insulin needs to be secreted to accomplish a given task. This is
beneficial while dieting because insulin is anti-lipolytic.
Summary
OEA and SEA decrease appetite
Consuming less
calories leads to fat loss
OEA and TTA activate PPARalpha
Activation of PPARalpha increase the rate and capacity of fat
oxidation
The combination of a decreased caloric intake and
elevated fatty acid oxidation ensures fat loss success
If
you’re interested in not only optimizing your health but also
decreasing appetite and enhancing fat loss all while preserving
precious lean muscle, LipidFX is the perfect supplement for
you!
Supplement Facts
Serving Size: 4 Vegetarian
Capsules
Servings Per Container: 30
Amount Per Serving %
DV
TTA (TetradecylThioacetic Acid) 1000 mg †
PhosphoLean™
(Standardized to 24% OEA (Oleoylethanolamide) and 14% EGCG
(epigallocatechin gallate)) 350 mg †
SEA (Stearoylethanolamide)
250 mg †
† Daily Value Not
Established.
References:
1. Proulx K, Cota D,
Castaneda TR, Tschop MH, D'Alessio DA, Tso P, Woods SC, Seeley
RJ. Mechanisms of oleoylethanolamide-induced changes in feeding
behavior and motor activity. Am J Physiol Regul Integr Comp
Physiol. 2005 Sep;289(3):R729-37.
2. Fu J, Oveisi F, Gaetani
S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous
PPAR-alpha agonist, lowers body weight and hyperlipidemia in
obese rats. Neuropharmacology. 2005 Jun;48(8):1147-53.
3.
Terrazzino S, Berto F, Dalle Carbonare M, Fabris M, Guiotto A,
Bernardini D, Leon A. Stearoylethanolamide exerts anorexic
effects in mice via down-regulation of liver stearoyl-coenzyme A
desaturase-1 mRNA expression. FASEB J. 2004 Oct;18(13):1580-2.
Epub 2004 Aug 2.
4. Dobrzyn A, Ntambi JM The role of
stearoyl-CoA desaturase in the control of
metabolism.
Prostaglandins Leukot Essent Fatty Acids. 2005
Jul;73(1):35-41.
5. Fu, J., et al. Oleylethanolamine regulates
feeding and body weight through activation of the nuclear
receptor PPAR-á. Nature 425, 90-93 (2003)
6. J Agric Food Chem.
2001 May;49(5):2647-51
7. Madsen L, et al. Tetradecylthioacetic
acid prevents high fat diet induced adiposity and insulin
resistance. J Lipid Res. 2002 May;43(5):742-50.
|
