Description 
  Cholesterol Control - Maintains levels within 
the normal range 
  
Cardiovascular Support Formula Patented 
Complex
SytrinolT is a powerful blend of bioflavonoids 
(polymethoxylated flavones) and tocotrienols extracted from 
natural citrus and palm fruits.
Clinically Tested
In multiple 
ways, SytrinolT positively affects the amount of cholesterol and 
triglycerides produced by the body.
 

 
   
 Supplement 
Facts
Serving Size: 1 Softgel
Servings per container: 60 
Amount Per Serving  % Daily Value  
 
Sytrinol (Proprietary 
blend of natural citrus and palm fruit extract) 150 mg * 
*Daily value not established.  
  
 
 

Other ingredients: 
Extra virgin olive oil, Gelatin (softgel), Glycerin, Purified, 
Lecithin, Yellow beeswax, Natural orange flavor, Titanium 
dioxide and Chlorophyllin.

 

Free Of 
  Artificial 
ingredients, preservatives, yeast, milk, lactose, wheat, sugar, 
soy or corn. 

Directions 
  Take 1 softgel twice daily, or 
as directed by your healthcare professional. 

Warnings 
  If 
you are pregnant or lactating, consult your healthcare 
professional before using this product. 

Disclaimer 
  These 
statements have not been evaluated by the FDA. These products 
are not intended to diagnose, treat, cure, or prevent any 
disease. 

Description 
  Cholesterol Control - Maintains levels within 
the normal range 
  
Cardiovascular Support Formula Patented 
Complex
SytrinolT is a powerful blend of bioflavonoids 
(polymethoxylated flavones) and tocotrienols extracted from 
natural citrus and palm fruits.
Clinically Tested
In multiple 
ways, SytrinolT positively affects the amount of cholesterol and 
triglycerides produced by the body.
 

 
   
 Supplement 
Facts
Serving Size: 1 Softgel
Servings per container: 60 
Amount Per Serving  % Daily Value  
 
Sytrinol (Proprietary 
blend of natural citrus and palm fruit extract) 150 mg * 
*Daily value not established.  
  
 
 

Other ingredients: 
Extra virgin olive oil, Gelatin (softgel), Glycerin, Purified, 
Lecithin, Yellow beeswax, Natural orange flavor, Titanium 
dioxide and Chlorophyllin.

 

Free Of 
  Artificial 
ingredients, preservatives, yeast, milk, lactose, wheat, sugar, 
soy or corn. 

Directions 
  Take 1 softgel twice daily, or 
as directed by your healthcare professional. 

Warnings 
  If 
you are pregnant or lactating, consult your healthcare 
professional before using this product. 

Disclaimer 
  These 
statements have not been evaluated by the FDA. These products 
are not intended to diagnose, treat, cure, or prevent any 
disease. 

Cholesterol Formula 
Cardiovascular Health 
150 mg Sytrinol® / 
10 mg Policosanol 
Maintains Healthy Range Cholesterol and 
Triglyceride Levels* 
Vegetarian Formula
NOW® Sytrinol® 
Cholesterol Formula contains the patented and clinically tested 
ingredient, Sytrinol®.  Sytrinol® is a proprietary formula 
consisting of polymethoxylated flavones (PMF's) from citrus, 
palm tocotrienols and other proprietary constituents.  Studies 
have shown that Sytrinol® helps maintain cholesterol and 
triglyceride levels already within the healthy range.  NOW® 
Sytrinol® Cholesterol Formula also contains Policosanol, a blend 
of long-chain fatty alcohols (LCFA) derived from sugar cane for 
its synergistic effect.  In addition, Milk Thistle and Alpha 
Lipoic Acid have been included for their antioxidant effects, as 
well as to support liver health.  This combination of 
ingredients makes NOW® Sytrinol® Cholesterol Formula an ideal 
supplement for naturally supporting overall cardiovascular 
function.*
 
 
 

 Nutrition Info   
  Serving Size 1 
Vcap® 
 
   Amount Per Serving  % Daily Value  
Chromium 
(from Chromium Chelavite® Amino Acid Chelate)   60 mcg    50% 
Sytrinol® (Proprietary Blend of Natural Citrus and Palm Fruit 
Extract)   150 mg    †   
Milk Thistle Extract (Silybum 
marianum) (Fruit/Seeds) (min. 80% Silymarin)   50 mg    † 
Alpha Lipoic Acid   50 mg    †   
Policosanol (frm Sugar Cane) 
10 mg    †   
* Percent Daily Values are based on 2,000 calorie 
diet.
† Daily Value not established. 
Details  
Serving Size:  1 Vcap®
 
Suggested Usage:  As a 
dietary supplement, take 1 Vcap® twice daily.
 
Other 
Ingredients:  Cellulose (capsule), Cellulose, Tapioca Flour, 
Magnesium Stearate (vegetable source) and Silica. 
Vegetarian/Vegan Product.
 
Contains no:  salt, yeast, wheat, 
gluten, corn, soy, milk, egg, shellfish or preservatives. 
Caution:  Do Not Eat Freshness Packet.  Keep in Bottle. 
Disclaimers:  *These statements have not been evaluated by the 
FDA.  This product is not intended to diagnose, treat, cure or 
prevent any disease. 

Cholesterol Formula 
Cardiovascular Health 
150 mg Sytrinol® / 
10 mg Policosanol 
Maintains Healthy Range Cholesterol and 
Triglyceride Levels* 
Vegetarian Formula
NOW® Sytrinol® 
Cholesterol Formula contains the patented and clinically tested 
ingredient, Sytrinol®.  Sytrinol® is a proprietary formula 
consisting of polymethoxylated flavones (PMF's) from citrus, 
palm tocotrienols and other proprietary constituents.  Studies 
have shown that Sytrinol® helps maintain cholesterol and 
triglyceride levels already within the healthy range.  NOW® 
Sytrinol® Cholesterol Formula also contains Policosanol, a blend 
of long-chain fatty alcohols (LCFA) derived from sugar cane for 
its synergistic effect.  In addition, Milk Thistle and Alpha 
Lipoic Acid have been included for their antioxidant effects, as 
well as to support liver health.  This combination of 
ingredients makes NOW® Sytrinol® Cholesterol Formula an ideal 
supplement for naturally supporting overall cardiovascular 
function.*
 
 
 

 Nutrition Info   
  Serving Size 1 
Vcap® 
 
   Amount Per Serving  % Daily Value  
Chromium 
(from Chromium Chelavite® Amino Acid Chelate)   60 mcg    50% 
Sytrinol® (Proprietary Blend of Natural Citrus and Palm Fruit 
Extract)   150 mg    †   
Milk Thistle Extract (Silybum 
marianum) (Fruit/Seeds) (min. 80% Silymarin)   50 mg    † 
Alpha Lipoic Acid   50 mg    †   
Policosanol (frm Sugar Cane) 
10 mg    †   
* Percent Daily Values are based on 2,000 calorie 
diet.
† Daily Value not established. 
Details  
Serving Size:  1 Vcap®
 
Suggested Usage:  As a 
dietary supplement, take 1 Vcap® twice daily.
 
Other 
Ingredients:  Cellulose (capsule), Cellulose, Tapioca Flour, 
Magnesium Stearate (vegetable source) and Silica. 
Vegetarian/Vegan Product.
 
Contains no:  salt, yeast, wheat, 
gluten, corn, soy, milk, egg, shellfish or preservatives. 
Caution:  Do Not Eat Freshness Packet.  Keep in Bottle. 
Disclaimers:  *These statements have not been evaluated by the 
FDA.  This product is not intended to diagnose, treat, cure or 
prevent any disease. 

Sytrinol is a formula derived from citrus and palm fruit extracts. It is a combination of citrus flavonoids and palm-sourced tocotrienols that can exert potent antioxidant effects. This product may have its major effect in the liver by acting there to balance the production of cholesterol. Research shows that it may be beneficial in helping to maintain normal cholesterol levels in healthy people.*

Helps maintain normal cholesterol levels in healthy individuals.* Contains nothing other than listed ingredients.

Suggested adult use: One softgel two times daily, with or without food.

Supplement Facts
Serving Size: 1 softgel
Servings Per Container: 60
Amount Per Serving % Daily Value
This product
(a proprietary blend of citrus polymethoxylated flavones and palm tocotrienols) 150 mg †
† Daily Value not established.

Other Ingredients: Extra virgin olive oil, gelatin, glycerin, purified water, lecithin, yellow beeswax, orange natural flavor, titanium dioxide, chlorophylline, riboflavin based colorant (for imprint).

Expiration Date: Approx. 2 years from the date of purchase.

60 Softgel Caps

Research into the way in which PMFs modulate the production of cholesterol has revealed potential mechanisms of action. One such in vitro trial looked at the effect of tangeretin on human HepG2 cells, a model commonly used to study the metabolism of lipids. This study found that when these cells are exposed to tangeretin, the rate of Apoprotein B production rapidly decreases.1 Apoprotein B is a structural protein that controls the synthesis of LDL cholesterol from the cells. The study showed that tangeretin inhibited apoprotein B secretion in a dose-dependant manner.

Another interesting component that was measured in this study was tangeretin's effectiveness in a lipid-rich environment. The cells were bathed in the tangeretin solution in the presence of a high amount of fat. In this environment, tangeretin possessed the same ability to decrease apoprotein B secretion.1 It was thus shown that tangeretin can be effective at modulating the production of cholesterol in a variety of cellular environments.

The researchers also showed that tangeretin may modulate the production of triglycerides on an enzymatic level. Triglycerides are an important component of the body's lipid profile, and play a role in human health similar to other cholesterol components. Microsomal triglyceride transfer protein (MTP) and diacylglycerol acyltransferase (DGAT) are two components of triglyceride synthesis and transport within the cells. Tangeretin displayed inhibitory effects on MTP and suppressed the activity of DGAT, thereby affecting triglyceride metabolism.1

A 2005 in vitro study looked at the effects of the second major PMF present in Sytrinol , nobiletin. The results of this study showed that nobiletin, in addition to being able to modulate the production of cholesterol, has important free radical scavenging effects in the bloodstream.2

It is well known that the levels of cholesterol in the bloodstream are not the only factor in determining cardiovascular risk. Just as important, if not more important, is the state of oxidation of LDL cholesterol molecules. Oxidized LDL may deposit in blood vessels and increase cardiovascular risk factors. Nobiletin was shown to prevent oxidative damage to LDL molecules in this study.2 In purveying its potent antioxidant effect, it keeps the LDL molecules healthy and prevents them from causing potential harm.*

A recent trial was conducted in hamsters to measure the effectiveness of a combination of tangeretin and nobiletin on serum cholesterol levels. This controlled trial investigated the effect of including these PMFs into the diet for 5 weeks. The control group received a normal, standardized diet free of PMFs. Blood parameters were measured and at the end of the experimental period, the animals fed the tangeretin/nobiletin combination showed significantly favorable results in a number of lipid parameters.3 This research highlights the ability of these PMFs to have beneficial effects on the maintenance of cardiovascular health.*

Tocotrienols: Research Summary

A number of studies have highlighted the cardiovascular health benefits of tocotrienols. Animal studies have shown important serum lipid modulating functions of various tocotrienols. A study conducted in rats found that supplementation of their diets with gamma-tocotrienol resulted in significant effects on total and LDL cholesterol levels after 6 weeks.4A second study assessed the impact of feeding tocotrienol-rich rice bran oil to chickens. The results also showed significant decreases in total and LDL cholesterol levels.5

Additional in vitro and animal research has documented the far-reaching benefits of tocotrienols on a number of cardiovascular markers. Some of the most interesting research shows amazing antioxidant abilities of these compounds, including an ability to protect LDL cholesterol molecules from lipid peroxidation, thus preventing them from becoming harmful.6 This is also a noted effect of PMFs.

According to in vitro trials, tocotrienols work to modulate cholesterol synthesis at the enzymatic level. This action is unique to these compounds and researchers believe that this mechanism is responsible for the positive results seen in the animal studies.6

Two human trials with tocotrienols have also shown positive results on lipid profiles. Tocotrienol-rich palm oil or rice bran oil was used in these studies and they both showed significant effects on plasma cholesterol levels.6 The various mechanisms of action of tocotrienols make them an ideal choice for promoting heart health.

Sytrinol : Human Clinical Trials

Sytrinol combines the benefits of PMFs and tocotrienols in one convenient formula to promote cardiovascular health.* Two initial small clinical trials were conducted to determine the effectiveness of this product at maintaining healthy cholesterol levels already in the normal range.7

Both showed very positive results evidenced by a healthy impact on plasma cholesterol, LDL and triglyceride levels. Based on these results a larger clinical trial of 120 people was conducted with highly favorable results. This trial is due for publication soon.7 The promising results of this trial and prior research place Sytrinol as a safe and effective cornerstone of cardiovascular health maintenance and wellness protocols.*

Safety

Suggested adult use: One softgel two times daily, with or without food.

Does Not Contain: milk, egg, wheat, corn, sugar, sweeteners, starch, salt, or preservatives.

Scientific References

1. Kurowska EM, Manthey JA, et al. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids. 2004 Feb;39(2):143-151.

2. Whitman SC, Kurowska EM, et al. Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. Atherosclerosis. 2005 Jan;178(1):25-32.

3. Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004 May 19;52(10):2879-86.

4. Watkins T, Lenz P, et al. gamma-Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets. Lipids. 1993 Dec;28(12):1113-8.

5. Qureshi AA, Mo H, Packer L, Peterson DM. Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant, and antitumor properties. J Agric Food Chem. 2000 Aug;48(8):3130-40.

6. Theriault A, Chao JT, Wang Q, Gapor A, Adeli K. Tocotrienol: a review of its therapeutic potential. Clin Biochem. 1999 Jul;32(5):309-19.

7. Press Release. "SourceOne announces completion of phase III of Sytrinol ™ long-term clinical trial." NPI Center. URL: http://www.npicenter.com (25 Jan 2005).

Sytrinol™

Sytrinol™

Sytrinol is a patented proprietary formula derived from natural 
citrus polymethoxylated flavones (PMFs) and palm tocotrienols 
exclusively marketed worldwide SourceOne Global Partners for use 
in dietary supplements.  This combination results in a 
synergistic effect for significantly lowering total cholesterol, 
LDL cholesterol, and triglyceride levels.  Sytrinol has also 
been shown to increase HDL levels. Additionally, Sytrinol is a 
powerful antioxidant with numerous heart health benefits 
including the reduction of arterial plaque, improved glycemic 
control and reduced blood platelet aggregation. 

Source Naturals introduces the science of patented Sytrinol™, 
part of the Cholesterol Rescue™ family of products. Sytrinol 
helps to maintain cholesterol levels that are already within the 
normal range. Contrary to popular belief, the amount of 
cholesterol produced by the liver is much more significant to 
total cholesterol levels than cholesterol consumed from dietary 
sources. Preliminary clinical research shows that Sytrinol may 
assist in maintaining a balanced production of cholesterol by 
the liver. Support your cholesterol wellness with Source 
Naturals Sytrinol today.

Supplement Facts for 
softgels
Serving Size: 1 Softgel  
  Amount %DV 
Sytrinol™ 
(proprietary blend of citrus polymethoxylated flavones and palm 
tocotrienols) 150 mg † 
 

Other Ingredients: extra virgin 
olive oil, gelatin, glycerin, purified water, natural orange 
flavor, lecithin, yellow beeswax, , titanium dioxide, 
chlorophylline, and riboflavin based colorant.

Warning: If 
you are pregnant or breastfeeding, consult your health care 
professional before using this product.

Suggested Use: 1 
softgel twice daily, or as recommended by your health care 
professional. 

Source Naturals introduces the science of patented Sytrinol™, 
part of the Cholesterol Rescue™ family of products. Sytrinol 
helps to maintain cholesterol levels that are already within the 
normal range. Contrary to popular belief, the amount of 
cholesterol produced by the liver is much more significant to 
total cholesterol levels than cholesterol consumed from dietary 
sources. Preliminary clinical research shows that Sytrinol may 
assist in maintaining a balanced production of cholesterol by 
the liver. Support your cholesterol wellness with Source 
Naturals Sytrinol today.

Supplement Facts for 
softgels
Serving Size: 1 Softgel  
  Amount %DV 
Sytrinol™ 
(proprietary blend of citrus polymethoxylated flavones and palm 
tocotrienols) 150 mg † 
 

Other Ingredients: extra virgin 
olive oil, gelatin, glycerin, purified water, natural orange 
flavor, lecithin, yellow beeswax, , titanium dioxide, 
chlorophylline, and riboflavin based colorant.

Warning: If 
you are pregnant or breastfeeding, consult your health care 
professional before using this product.

Suggested Use: 1 
softgel twice daily, or as recommended by your health care 
professional. 

addition to Sytrinol (TM), this formula also contains CoQ10, a 
powerful antioxidant necessary for proper function and 
performance of the heart muscle.* Supporting the heart, along 
with maintaining proper cholesterol and triglyceride levels, are 
essential to cardiovascular health.

Recommendation: Take 1 
softgel twice daily, or as directed by your healthcare 
professional. 


Natural formula. Contains no artificial 
ingredients, preservatives, yeast, milk, lactose, wheat, sugar, 
soy or corn. 

Caution: If you are pregnant or lactating, 
consult your healthcare professional before using this product. 

In addition to Sytrinol (TM), this formula also contains premium 
fish oil (providing 30% EPA & 20% DHA). Supportive but not 
conclusive research shows that consumption of EPA and DHA 
Omega-3 fatty acids may reduce the risk of coronary heart 
disease.

Recommendation: Take 1 softgel twice daily, or as 
directed by your healthcare professional. 

Caution: If you 
are pregnant or lactating, consult your healthcare professional 
before using this prod 

In addition to Sytrinol (TM), this formula also contains premium 
fish oil (providing 30% EPA & 20% DHA). Supportive but not 
conclusive research shows that consumption of EPA and DHA 
Omega-3 fatty acids may reduce the risk of coronary heart 
disease.

Recommendation: Take 1 softgel twice daily, or as 
directed by your healthcare professional. 

Caution: If you 
are pregnant or lactating, consult your healthcare professional 
before using this prod 

Recommendation: Take 1 softgel twice daily, or as directed by 
your healthcare professional. 

Caution: If you are pregnant 
of lactating, consult your healthcare professional before using 
this product.

*These statements have not been evaluated by 
the Food & Drug Administration. This product is not intended to 
diagnose, treat, cure or prevent any 
disease.

Ingredients:
Serving Size 1 Softgel
Servings per 
Container 60
Calories 5
Sytrinol (TM) (proprietary blend of 
natural citrus and palm fruit extracts) 150 mg.
Phytosterols 
(from non-GMO soy) 100 mg. 

Other ingredients: extra virgin 
olive oil, gelatin (softgel), glycerin, purified water, annatto 
(seed) extract, yellow beeswax, titanium dioxide. 

Natural 
formula. Contains no artificial ingredients, preservatives, 
yeast, milk, lactose, wheat, sugar or corn.