Folic acid enhances Chemotherapy - Folic acid enhances Chemotherapy
Scientists have discovered
that cancer cells have
a natural attraction to folic
acid. This safe constituent
of vitamin B is now being
used as a nontoxic “Trojan
horse” to carry chemotherapy
directly to various cancers.
Researchers reported
at the 4th annual Gene,
Drug Therapy and
Molecular Biology meeting
that the vitamin can be
used with conventional
chemotherapy drugs and a
variety of new gene therapies
to destroy cancer cells.
Scientists have repeatedly
found that folic acid is
overexpressed in certain
cancers: specifically, cancers
of the ovary, cervix,
endometrium, kidney,
breast, brain, lung and
colon. Scientists found that
folic acid is especially overexpressed
on tumors that
are resistant to conventional
chemotherapy. Dr. Philip
Low of Purdue University
and chief scientific officer at
Endocyte, Inc. based in
Lafayette, Indiana, told
attendees that folic acid
could become a perfect carrier
for many types of tumor
targeting.
Endocyte researchers
estimate that cancers that
overexpress the folate
receptor are diagnosed in
about 300,000 people each
year in the US.
This new specific targeting
approach exploits cancer
cells' insatiable appetite
for folic acid. Compared to
healthy cells, researchers
say that cancer cells have
500,000 times greater affinity
for folic acid. The folic
acid that these cells ravenously
seek can be used to
target and deliver drugs to
easy-to-find and hard-toreach
cancer cells at the
same time while avoiding
normal, healthy cells.
Folic acid does not trigger
an immune response in the
human body. It is readily
available, easy to produce
on large scale, and can be
attached to a great number
of drugs.
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