Quercetin and Bromelain - Maintains Tissue Comfort by Regulating Enzymes*
Helps Maintain Normal Blood Viscosity*
Bromelain May Enhance Quercetin Absorption
Benefits
Down-regulates the Body’s Response to Environmental Challenges
Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids.
Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein.1 Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist.1 Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action.2 Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability.3 Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells.4 A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils.5,6,7,8,9,10
Quercetin modifies the body’s response to antigenic substances.* Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing granules in mast cells.3 Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges.
Maintains Tissue Comfort by Regulating Enzymes*
Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the rele ...
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