Cinnamon and Blood Sugar - Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout
the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.
Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek,
cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of
these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously
hypertensive rats (SHRs), a model of genetic hypertension.
Material and Methods: Water or essential oils were given orally via droplets, and insulin sensitivity was
estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.
Results: We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin
sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs,
suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two
additional combinations of essential oils along with the original formula. The major differences were in the types and
proportions of individual oils contributing to a given formula.
Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the
others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added
to the long list of natural products that can affect insulin sensitivity.
Keywords: diabetes mellitus, essential oils, insulin resistance, insulin sensitivity, insulin sensitivity, natural products
Received 11 August 2003; returned for revision 25 September 2003; revised version accepted 16 March 2004
Introduction
The prevalence of insulin resistance and its mo ...
example,
supplementary niacin-bound chromium [20,21],
garlic [22], soluble fibres [23] and vanadium [24] can
overcome, to some extent, many of these perturbations.
Thus, natural nutrients/elements have the potential to
favourably influence the glucose/insulin system and the
onset of age-related chronic disorders with little threat of
serious adverse side effects [1]. We should mention that it
is possible that proper combinations of these natural products
may give even better risk/benefit ratios than single
agents alone.
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VitaNet ®
VitaNet ® Staff ...Fenugreek and cinnamon
have had extensive studies devoted to their anti-diabetic
properties. The major action of fenugreek may be
via blockage of glucose absorption [35]. Cinnamon has
been shown to have insulin-like action [38] and affect
insulin signalling [39]. There is little association of diabetes
treatment with cumin, pumpkin seed and oregano
[35], although animal studies do suggest that cumin may
lower circulating lipid levels in diabetic rats [40]. The
long-term safety of these condiments in the food supply
suggests the possibility of daily use over the long haul to
prevent or ameliorate insulin resistance and perhaps
even increase useful lifespan [1,41]. Previous studies
with other natural products have suggested this potential
[42]. Future studies are necessary to test the veracity
of this hypothesis.
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