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Treatment of alcohol dependence or alcohol abuse - For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough
literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies,
including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol
addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the
history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11
most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion:
to deter patients from further drinking by associating alcohol drinking with an unpleasant experience.
Interestingly, as time went by, treatments based solely on psychological aversion were gradually
eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness
and/or undesirable side effects. The only remedies that have survived this historical trial-anderror
scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP)
of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this
historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol
intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone
that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested
to date.
Alcohol abuse
Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, ...
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