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healthy joints and positive moods*
Features & Benefits
SAMe (S-Adenosyl-l-Methionine) is a naturally-occurring metabolite
which plays an important part in over 35 metabolic processes.*1,2 It is
naturally produced by the body from the amino acid methionine and
energy-producing ATP (Adenosine Triphosphate). An increase of methionine
doesn’t guarantee an adequate level of SAMe which also depends on
sufficient amounts of folic acid and vitamin B-12 as well as optimum
functioning of enzyme systems.
The elderly normally have decreased levels of SAMe, so supplementation may be recommended. SAMe is essential to the synthesis, activation and metabolism of hormones, neurotransmitters, nucleic acids, and to the integrity of cell membranes.*1,2
Since synthesis of SAMe is intimately linked with vitamin B-12 and folic acid, deficiencies in both of these vitamins have been found to correlate with lowered SAMe levels and concentration.*1,2 SAMe’s chief metabolic role is methylation, the donation of a methyl group (carbon unit) to another molecule.*1,3 This donation aids in the detoxification of the liver, maintenance of cell membranes, and the production of neurotransmitters.*4 The formation of neurotransmitters such as dopamine indicates that SAMe also has a function in mood regulation.*1,2,5
In a preliminary double-blind, placebo-controlled clinical trial, it was demonstrated that SAMe possesses the ability to rapidly improve moods with minimal side effects.*6,7,8,9 SAMe also helps people with tenderness at various points in their body.*10 In a double-blind study, 44 people pre-disposed to tenderness and stiffness, reduced muscle strength, and negative moods were monitored after taking 800 mg/day of SAMe. The results indicate that SAMe provided beneficial effects for these individuals, and was well-tolerated.*10
The naturally-occurring cyclical end of SAMe metabolism is the generation of sulfate groups which help maintain cartilage in joints.*11 In two separate randomized double-blind studies, a total of 72 people used a daily dose of 1,200 mg of SAMe. The results indicate significant improvement in joint mobility with little or no side effects.*12,13 Many other human studies have confirmed these results.14
SAMe may also provide support to the liver by replenishing
antioxidants and other important substances, increasing the fluidity of
membranes and improving the flow of bile.*3,4,15
Safety of SAMe
At daily doses between 400 mg and 1,200 mg, no significant side
effects of SAMe supplementation were reported. Occasional side effects
affecting a small percentage of people included gastrointestinal upset.
Individuals being treated for neurological conditions should consult their
healthcare practitioner before using.
S-Adenosyl l-Methionine is very sensitive to moisture and heat,
therefore it requires careful formulating with stabilizing compounds and
a protective enteric coating. Nature's Life SAMe Complex tablets contain
50%-52% of the active ingredient, enhanced with 48%-50% stabilizers. These
other ingredients guard the delicate SAMe compound. If tablet
disintegration occurs in the stomach, little or no absorption of SAMe will
occur. Nature's Life's enteric-coated tablet passes into the duodenum (the
first portion of the small intestine) to be broken down by digestive
enzymes secreted by the pancreas. The pH level in the small intestine
provides an alkaline environment for maximum absorption of SAMe.
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- Support Joint Comfort, Function and Mobility
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- Promotes Joint Comfort and Mobility*
- SAMe - AMINO ACIDS TO SUPPORT POSITIVE MENTAL FUNCTION