The gold standard in transdermal bioidentical progesterone for women experiencing the unpredictable hormonal shifts of perimenopause and menopause.
✓ 450 mg USP Progesterone Per ounce (approx. 20 mg per 1/4 teaspoon).Hormone changes do not happen overnight. In the years leading up to menopause (a phase known as perimenopause), ovulation becomes irregular. When an ovary does not release an egg, your body does not produce the expected wave of natural progesterone. Meanwhile, estrogen levels can swing dramatically high and low.
This mismatch is often described as estrogen dominance. Without enough progesterone to keep estrogen in balance, many women experience disruptive everyday discomforts:
The Bioidentical Difference: Emerita Pro-Gest provides micronized USP Progesterone derived from natural plant compounds found in wild yam (Dioscorea villosa). In a specialized laboratory setting, the plant's diosgenin is converted to match the molecular structure of the progesterone your own body naturally produces. This is fundamentally different from synthetic prescription progestins, which have altered chemical shapes.
Unlike many topical cosmetic creams on the market that make vague promises, Emerita Pro-Gest has been the subject of formal clinical investigation published in peer-reviewed medical literature. We believe in providing complete transparency about what clinical studies showed—and what they did not.
In a randomized, double-blind, placebo-controlled clinical trial led by Dr. Helene B. Leonetti, researchers tested transdermal Pro-Gest cream containing 20 mg of progesterone per quarter-teaspoon dose daily on postmenopausal women over a 1-year period:
Citation: Leonetti HB, Longo S, Anasti JN. "Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss." Obstet Gynecol. 1999 Aug;94(2):225-228. doi:10.1016/s0029-7844(99)00266-7. PMID: 10432132.
Topical delivery offers an important biological advantage: applying progesterone to the skin allows lipophilic (fat-soluble) progesterone molecules to be absorbed directly into the underlying microvasculature. This bypasses the digestive tract and avoids the liver's "first-pass metabolism," which can break down over 85% of oral progesterone before it reaches systemic circulation.
Citation: Cooper A, Spencer C, Whitehead MI, Ross D, Barnard GJ, Collins WP. "Systemic absorption of progesterone from Progest cream in postmenopausal women." Lancet. 1998 Apr 25;351(9111):1255-1256. PMID: 9643756.
Some early wellness books claimed over-the-counter progesterone cream builds new bone mass. However, rigorous clinical trials (including the Leonetti 1999 and 2003 follow-up trials) confirmed that transdermal progesterone cream alone does not prevent postmenopausal bone loss or rebuild bone mineral density. Women seeking osteoporosis prevention should speak with their doctor regarding comprehensive strategies including resistance training, dietary calcium, vitamin D3/K2, and approved medical therapies.
Using Emerita Pro-Gest is straightforward, but consistency and proper site rotation are essential for maintaining optimal skin absorption.
Gently squeeze out a dime-sized dollop of cream. This equals approximately 1/4 teaspoon, which provides 20 mg of bioidentical USP progesterone.
Most women apply this amount twice daily (once in the morning and once before bedtime) or as instructed by their healthcare practitioner.
Massage completely into thin-skinned, capillary-dense areas of your body until fully absorbed:
Target Sites: Inner wrists, inner forearms, chest/decolletage, inner thighs, lower abdomen, or back of the neck.
Pro-Tip: Rotate your application area each day to prevent local subcutaneous receptor saturation.
Start applying on Day 14 of your cycle (counting Day 1 as the first day of your period) through Day 28. Discontinue for the next 14 days while you bleed, then repeat. If bleeding begins early, stop using the cream and begin counting Day 1 again.
Protocol B: Postmenopausal Women (No Longer Having Periods)Apply daily for 21 to 25 consecutive days each calendar month, then rest for the remaining 5 to 7 days before starting again. Many women find it easy to use from the 1st of the month through the 25th, taking the rest of the month off.
Emerita Pro-Gest is formulated with a luxurious, non-greasy cream base that hydrates and softens skin while ensuring efficient transdermal transport. It contains zero mineral oil, no petrolatum, and no synthetic dyes or fragrances.
Bioidentical USP ProgesteroneStandardized to United States Pharmacopeia (USP) criteria for purity and strength. 450 mg per ounce.
Organic Aloe Vera Leaf JuiceSoothes skin surface, calms redness, and provides light water-based hydration without clogging pores.
Sweet Almond & Safflower OilsRich in essential fatty acids that support skin elasticity and assist in lipid-soluble carrier absorption.
Vitamin E & Provitamin B5 (Panthenol)Antioxidants that protect delicate skin tissues against oxidative stress while locking in smooth moisture.
Water (Purified), Tocopheryl Acetate (Vitamin E), Aloe Barbadensis (Aloe Vera) Leaf Juice, Carthamus Tinctorius (Hybrid Safflower) Seed Oil, Panthenol (Provitamin B5), Glycerin, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Glyceryl Stearate, Cetyl Alcohol, Sodium Behenoyl Lactylate, Stearic Acid, USP Progesterone, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Citrus Aurantium Dulcis (Orange) Oil, Citrus Medica Limonum (Lemon) Peel Oil, Carbomer.
Not all progesterone creams are created equal. Compare Emerita Pro-Gest 4 oz Value Size against standard 2 oz tubes and unstandardized wild yam cosmetic creams:
Your health and hormonal safety are our highest priorities. Please review the following medical precautions before beginning any new hormone-supportive regimen:
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Many women notice a calming sensation and improved sleep within the first 7 to 10 days of consistent use. For hot flashes and night sweats, published clinical research shows that maximum relief typically occurs within 3 to 4 weeks of consistent twice-daily application.
Because progesterone is lipophilic (fat-soluble), it can slowly accumulate in the subcutaneous fatty tissue right beneath the skin. Rotating application daily between your inner arms, wrists, upper chest, inner thighs, and neck ensures continuous, consistent systemic absorption and prevents localized receptor saturation.
Yes. Postmenopausal women often use Pro-Gest to help soothe ongoing hot flashes, night sweats, and sleep disturbances. The standard schedule for postmenopausal women is applying 1/4 teaspoon once or twice daily for 21 to 25 consecutive days each month, followed by a 5 to 7 day break to mimic natural hormonal rest periods.
No. While Pro-Gest originates from Mexican Wild Yam (Dioscorea villosa), the human body lacks the enzymes necessary to convert wild yam extracts or diosgenin into active progesterone on its own. Emerita Pro-Gest contains progesterone that has already been converted into USP (United States Pharmacopeia) bioidentical progesterone in a laboratory, meaning your cellular receptors recognize and utilize it immediately.
A 4 oz tube contains approximately 80 to 90 individual 1/4-teaspoon applications (providing 20 mg of USP progesterone each). If you apply it once daily on a 21-day cycle, one tube will last roughly 3 to 4 months. If applied twice daily (morning and evening), one tube will last approximately 6 to 8 weeks.
Unlike synthetic progestins (such as medroxyprogesterone acetate), which are frequently linked to fluid retention and weight changes, natural bioidentical progesterone actually acts as a mild natural diuretic. Many women find that by rebalancing relative estrogen dominance, it helps reduce premenstrual water retention and bloating.
VitaNet® LLC has been serving health-conscious customers online since 1995. We store all nutritional and personal care products in climate-controlled warehouses to ensure raw ingredient stability, offer an industry-leading 100% money-back guarantee, and ship fresh inventory directly from our Ohio fulfillment facility.
