Why does this formula include mixed tocopherols instead of just d-alpha tocopherol?

While d-alpha tocopherol is the main form recognized and circulated by your liver's carrier proteins, nature delivers vitamin E as a complete family of alpha, beta, delta, and gamma tocopherols. Research shows gamma-tocopherol is especially capable of disarming reactive nitrogen species, a damaging type of cellular stress in blood vessels that alpha-tocopherol cannot neutralize alone. Keeping all four tocopherols together mirrors real plant foods and delivers broader cellular defense.

What is the difference between natural d-alpha and synthetic dl-alpha vitamin E?

“d-alpha” is the natural form extracted directly from plants. Your liver produces a dedicated transport protein (a-TTP) that binds selectively to this exact molecular shape. “dl-alpha” is a synthetic molecule created from petroleum chemicals. Synthetic vitamin E contains eight distinct stereoisomer shapes, but your body can only properly use one, making synthetic vitamin E roughly 50% less bioavailable than natural d-alpha.

Can I pierce the softgel and apply the oil directly to my skin?

Yes. You can carefully snip the edge of the softgel with clean scissors and squeeze the golden oil onto your cuticles, dry skin patches, or minor skin blemishes. Because the carrier oil is organic extra virgin olive oil, it doubles as a soothing, clean topical moisturizer that delivers natural antioxidant hydration without artificial additives.

Will taking this softgel break an intermittent fast?

Yes, technically it will. The bovine gelatin capsule and organic olive oil base provide trace calories (about 2 to 3 calories). More importantly, fat-soluble vitamins require dietary fats from a complete meal to trigger bile release and enable proper absorption. For best results, take your softgel alongside your first solid meal when opening your eating window.

Is this product safe for people with soy sensitivities?

While the raw vitamin E is extracted from non-GMO soy, it undergoes thorough molecular distillation and purification that removes allergenic soy proteins. However, because the product is made in a facility that processes other ingredients containing allergens, individuals with severe, life-threatening soy allergies should consult their physician before use.

E-400 MT - 50 SGELS

by NOW FOODS

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NOW Foods Vitamin E-400 with Mixed Tocopherols (268 mg / 400 IU) – 50 Softgels

NOW Foods Vitamin E-400 provides 268 mg (400 International Units) of 100% plant-derived natural d-alpha tocopherol blended with natural mixed tocopherols (d-beta, d-delta, and d-gamma). Carried in certified organic extra virgin olive oil, this daily fat-soluble nutrient enters your system smoothly to protect your cell walls from everyday cellular wear and tear. It provides balanced antioxidant protection for your cardiovascular system, blood vessels, immune health, and skin without synthetic petrochemicals [1, 2].

Quick Specs Snapshot

✓ Active Form & Potency: 268 mg (400 IU) of pure natural d-alpha tocopherol per softgel (1,787% Daily Value), supported by natural d-beta, d-delta, and d-gamma mixed tocopherols.
✓ Primary Cellular Target: Cell membrane lipid bilayers, vascular walls, and circulating blood lipids, protecting delicate fats from free radical oxidation.
✓ Supply & Value Math: 50 easy-to-swallow softgels deliver a convenient 50-day supply (over 7 weeks), making it an accessible trial size for daily antioxidant support.
✓ Formulation Purity: Non-GMO plant origin, BSE-free bovine gelatin, suspended in certified organic extra virgin olive oil, and bottled in 100% post-consumer recycled (PCR) resin.

Buyer’s Guide: Natural vs. Synthetic Vitamin E

Why the Form Matters

The type of vitamin E you take determines how well your cells can use it. Lower-cost supermarket and big-box store formulas typically use synthetic vitamin E labeled as “dl-alpha tocopherol,” which is chemically manufactured from petroleum byproducts [1]. Synthetic vitamin E is a mixture of eight different mirror-image molecules, but your body can only fully use one of them [1]. Your liver produces a specialized escort protein called alpha-tocopherol transfer protein (α-TTP) that binds directly to natural d-alpha tocopherol like a custom key in a lock [1, 3]. Because of this natural biological fit, natural plant-derived vitamin E provides twice the retention and blood availability of synthetic forms [1]. Furthermore, NOW includes natural mixed tocopherols (d-beta, d-delta, and d-gamma) to match the diverse antioxidant balance found in nature [2].

Is This Formula Right for You?

Ideal For Shoppers Who:

✓ Want verified, plant-derived 400 IU (268 mg) natural vitamin E rather than cheap synthetic petrochemical forms [1].
✓ Want the broader protection of natural mixed tocopherols (beta, delta, and gamma) working in harmony with d-alpha [2].
✓ Prefer a practical 50-count bottle to evaluate digestive comfort and personal results before purchasing larger bulk sizes.

Consider Another Option If:

✗ You follow a strict vegan lifestyle (this softgel uses BSE-free bovine gelatin; consider a dry vegetarian capsule instead).
✗ You take prescription blood-thinning medications and have not yet consulted your healthcare practitioner about a 400 IU daily dose.
✗ You have serious fat-malabsorption concerns or lack a gallbladder and require an oil-free, water-soluble dry succinate powder.

Risk-Free Assurance from VitaNet®, LLC: Every purchase is backed by our unconditional 100% money-back guarantee—even on opened bottles, with return shipping covered by us—so you can evaluate this formula with complete confidence[cite: 1].

How It Works: Biochemical Pathways in Plain English

To understand how vitamin E protects your body, picture your cells as tiny homes. Every room is surrounded by an outer wall called a cell membrane, built largely from delicate fatty layers. Everyday activities like breathing, exercising, absorbing sunlight, and digesting food generate unstable molecules known as free radicals (such as reactive oxygen species, O₂^•−). Think of free radicals like flying sparks thrown off by a campfire. When these sparks strike your cell membranes, they set off a damaging chain reaction called lipid peroxidation, which is identical to cooking oil turning rancid or metal rusting [3].

Vitamin E (chemical formula C₂₉H₅₀O₂ for d-alpha tocopherol) is naturally fat-soluble. Because of its oily structure, it travels straight into your cell membranes and parks itself directly inside that fatty wall [3]. When an unstable free radical attacks, vitamin E acts like a protective shield: it donates an electron and a hydrogen atom to quench the spark immediately [2, 3]. This interrupts the harmful chain reaction before your cell wall can suffer damage [3].

The Mixed Tocopherols Advantage

NOW enriches this formula by adding natural mixed tocopherols. While d-alpha tocopherol is unmatched at disarming oxygen free radicals, gamma-tocopherol (C₂₈H₄₈O₂) features an open molecular position that captures reactive nitrogen species (such as nitrogen dioxide, NO₂), an aggressive type of cellular stress found inside blood vessels [2]. Suspended in organic extra virgin olive oil rich in oleic acid (C₁₈H₃₄O₂), these fat-soluble nutrients readily assemble into microscopic bubbles called micelles inside your digestive tract, promoting smooth uptake into your lymph and bloodstream [4].

Daily Dosing, Timing, and Helpful Combinations

Optimal Timing & Meal Pairing

Take 1 softgel daily with a meal containing wholesome dietary fats (such as eggs, avocado, yogurt, or olive oil) [4]. Because vitamin E dissolves only in fat, your digestive system requires food lipids to stimulate the release of bile from your gallbladder and lipolytic enzymes from your pancreas [4]. These digestive fluids create tiny transport spheres called micelles that ferry the tocopherols across your intestinal wall [3, 4]. Taking vitamin E on an empty stomach sharply reduces how much your body can absorb.

Daily Schedule & Habit Stacking

Because this formula delivers 268 mg (400 IU) in a single softgel, you only need one per day. Take your softgel consistently with breakfast or lunch. Fat-soluble vitamin E enters cell walls steadily and provides consistent 24-hour cellular protection throughout your daily routine [1].

Smart Synergies & Spacing Rules

✓ The Vitamin C Recharge Team: When vitamin E stops a free radical spark, it uses up an electron and becomes temporarily inactive. Vitamin C (ascorbic acid, C₆H₈O₆) acts like a rechargeable battery, donating an electron back to vitamin E so it can return to shielding your cell walls [3].
✗ The 2-Hour Spacing Rule: Keep your vitamin E softgel separated by at least 2 hours from inorganic iron supplements (such as ferrous sulfate) or fat-blocking weight-management supplements, which can bind to vitamin E in the gut and prevent absorption.

Timeline of Expectations

✓ Week 1 (Uptake & Circulation): The softgel breaks down cleanly in your digestive tract; active tocopherols enter circulating blood lipoproteins to protect blood lipids from immediate oxidation [1, 4].
✓ Weeks 3–4 (Cellular Saturation): Daily intake saturates deeper cell membranes, arterial walls, and skin tissue, building an active antioxidant reserve [1].
✓ Months 2–3+ (Long-Term Defense): Sustained tissue equilibrium supports blood vessel flexibility, skin hydration, and resilient defense against everyday oxidative stress [2, 3].

Capsule Details, Sensory Notes, and Clean Ingredients

Delivery Format & Swallowability

NOW Vitamin E-400 with Mixed Tocopherols comes in a smooth, oval bovine gelatin softgel. Its slick outer surface slides down easily with a standard sip of water, eliminating the scratchy throat sensation and swallowing difficulty common with large, dry tablets.

Natural Aroma, Taste & Color

When taken whole, the softgel is completely tasteless and odorless. Inside the capsule, the pure oil has a rich golden-amber tone. Because NOW Foods uses pure botanical tocopherols and organic olive oil without artificial food dyes or titanium dioxide, natural color variations from sunny gold to darker amber are expected across different harvest seasons.

Other Ingredients Demystified

✓ Bovine Gelatin (BSE-free): Certified safe, high-purity protein that creates an airtight capsule wall to seal delicate oils away from atmospheric oxygen.
✓ Glycerin: A plant-derived moisture stabilizer that keeps the softgel shell supple so it will not become brittle or leak on the shelf.
✓ Water: Purified water utilized during the softgel encapsulation process.
✓ Organic Extra Virgin Olive Oil: Cold-pressed, unrefined Mediterranean olive oil rich in oleic acid (C₁₈H₃₄O₂) that holds the fat-soluble vitamins in solution for gentle digestive absorption [4].
✓ Mixed Tocopherols (d-beta, d-delta, d-gamma): Natural botanical tocopherol fractions that shield active d-alpha tocopherol from oxidation while supplying full-spectrum cell protection [2].
✓ Non-GMO Highly Refined Soy Source: Sourced from non-GMO soy, but rigorously purified through molecular distillation to eliminate soy proteins, satisfying non-allergenic purity standards.

Storage & Eco-Friendly Packaging

Keep your bottle tightly closed in a cool, dry place after opening. Avoid hot kitchens, humid bathrooms, and sunny window ledges. The bottle is molded from 100% post-consumer recycled (PCR) resin, protecting your softgels from UV degradation while preventing plastic waste from entering our landfills and oceans.

Supplement Facts and NOW Quality Standards

Supplement Facts

Serving Size: 1 Softgel

Servings Per Container: 50

Description	Amount per Serving	% Daily Value
Vitamin E (as d-alpha Tocopherol)	268 mg	1787%

Other Ingredients: Softgel Capsule [bovine gelatin (BSE-free), glycerin, water], Organic Extra Virgin Olive Oil and Mixed Tocopherols (d-beta, d-delta, d-gamma).

Allergen Notice: Vitamin E from non-GMO soy (highly refined). Not manufactured with yeast, wheat, gluten, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.

Natural color variations may occur in this product. Store in a cool, dry place after opening. Family and employee owned. Made and quality tested in the USA with globally sourced ingredients.

NOW Brand In-House Lab Testing & Contaminant Screening

Many discount supermarket and big-box store brands cut costs by purchasing cheap bulk softgels from unverified overseas middlemen, rarely testing beyond a paper specification sheet before shipping to stores. In sharp contrast, NOW maintains world-class, ISO/IEC 17025 accredited in-house testing laboratories, conducting more than 19,000 analytical tests every month to verify absolute safety, potency, and purity.

Curator’s Quality Assurance Note

Curated by the VitaNet®, LLC Nutritional Biochemistry Team. Founded in 1995 as an independent, family-operated health retailer in Hartville, Ohio, VitaNet®, LLC brings over 31 years of direct supplement curation and biochemical expertise to your doorstep[cite: 1]. As a BBB A+ accredited retailer, we review raw ingredient sources and independently verify manufacturer lab testing so you never have to settle for questionable supermarket brands[cite: 1]. You can purchase with complete peace of mind knowing your order is backed by our unconditional 100% money-back guarantee—even on opened bottles, with return shipping covered[cite: 1].

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.