NOW Extra Strength Phosphatidyl Serine 300 mg – 50 Softgels

NOW Foods Extra Strength Phosphatidyl Serine 300 mg delivers a high-potency dose of pure brain-nourishing phospholipids in just one single daily softgel [1, 2]. Formulated in a clean base of fast-digesting MCT oil, this formula supports brain cell membranes and promotes healthy intercellular communication [1]. It helps maintain sharp memory, quick recall, and everyday mental clarity as you age [1, 2].

Quick Specs Snapshot

• ✓ Active Form & Potency: 300 mg of pure Phosphatidyl Serine per softgel—delivering three times the strength of standard 100 mg capsules.
• ✓ Primary Cellular Target: Brain cell membranes, neurotransmitter receptors, and nerve signaling pathways [1, 2].
• ✓ Supply & Value Math: 50-day supply (nearly two months) per bottle; replaces three standard pills daily to save you money.
• ✓ Formulation Purity: Suspended in clean MCT oil; non-GMO; free of gluten, dairy, wheat, and shellfish; packaged in an eco-friendly 100% PCR recycled bottle.

Buyer's Guide: Is NOW Extra Strength Phosphatidyl Serine Right for You?

Why the Form Matters

Most standard phosphatidylserine supplements on big-box store shelves provide only 100 mg per pill in dry powder capsules [1]. To get an effective daily dose, you are forced to swallow three bulky capsules every single day. Dry powder capsules can also be tough for your digestive system to break down and absorb because phosphatidylserine is naturally fat-soluble [4]. NOW Foods solves this by dissolving 300 mg of pure Phosphatidyl Serine directly into liquid MCT (medium-chain triglyceride) oil inside a smooth softgel, giving you three times the potency in a single pill with rapid absorption [1, 4].

Ideal For Shoppers Who:

• ✓ Want strong nutritional support for memory, focus, and verbal recall without swallowing a handful of pills every day [1, 2].
• ✓ Experience mid-afternoon brain fog, mental fatigue, or normal age-related forgetfulness [1, 2].
• ✓ Deal with busy, high-stress workdays and want natural support for healthy cortisol balance and calm mental focus [3].

Consider Another Option If:

• ✗ You have a severe allergy to soy (while this product uses highly refined soy where protein allergens are removed, those with extreme sensitivities may prefer sunflower-derived PS).
• ✗ You follow a strict vegan or vegetarian diet (this softgel is made with pure BSE-free bovine gelatin).
• ✗ You prefer a multi-herb brain blend with botanical stimulants (such as NOW Brain Elevate) rather than a pure, high-potency standalone phospholipid.

Risk-Free Assurance: Every purchase at VitaNet®, LLC is backed by our unconditional 100% money-back guarantee—we even cover return shipping if you are not completely satisfied, even on opened bottles, so you can test digestive comfort completely risk-free!

Biochemical Pathways: How Phosphatidyl Serine Powers Brain Cells

Your brain contains about 100 billion nerve cells called neurons. Every single neuron is wrapped in a protective fatty wall called a cell membrane. Phosphatidylserine (or PS for short) is a specialized phospholipid that forms a foundational building block of this membrane [1]. Here is how it supports your brain biology under the hood:

1. Keeping Brain Cell Walls Fluid and Flexible

Think of each brain cell as a house with flexible outer walls. When your diet provides plenty of phosphatidylserine, your cell membranes stay soft and fluid—much like olive oil rather than stiff, cold butter [1, 2]. This flexibility allows tiny receptor proteins to float and move easily, catching chemical signals from neighboring cells so messages travel at full speed [1].

2. Fueling Neurotransmitter Messengers

For your brain to recall a name or solve a math problem, it relies on chemical messengers called neurotransmitters. Phosphatidylserine stimulates the release and reception of acetylcholine (the primary chemical for learning and memory) and dopamine (the chemical for focus and mood) [1]. It helps your brain cells talk to one another smoothly across microscopic gaps called synapses [1, 4].

3. Supporting Synaptic Plasticity & Learning

Whenever you learn something new, your brain physically grows tiny branching arms and makes new connections between cells. This biological process is known as synaptic plasticity [1]. Phosphatidylserine provides the structural lipids your neurons need to repair worn-out cell walls and build strong connections, supporting long-term cognitive resilience [1, 4].

4. Moderating Cortisol and Everyday Stress

When you face high mental or physical stress, your adrenal glands produce a hormone called cortisol. While cortisol helps you react in an emergency, chronically high cortisol levels can damage brain cells and cause brain fog [3]. Clinical studies show that supplemental phosphatidylserine helps moderate excessive cortisol spikes, keeping your mind calm, focused, and steady under pressure [3].

Dosing, Timing & Daily Absorption Strategy

Optimal Timing & Meal Pairing

Take 1 softgel daily with a meal that contains healthy dietary fats, such as eggs, avocado, olive oil, or yogurt. Phosphatidylserine is a fat-soluble nutrient. While NOW suspends this formula in MCT oil to jumpstart absorption, eating a meal with natural fats triggers your body to release bile and digestive enzymes [4]. These enzymes break the softgel contents into tiny droplets called micelles, allowing optimal absorption through your intestinal lining [4].

Daily Schedule & Timing

Because NOW Extra Strength supplies a full 300 mg in a single softgel, you only need to take it once per day. Taking your softgel with breakfast or lunch is ideal, providing your brain cells with essential membrane lipids right before your workday begins. If you are using it primarily to support healthy cortisol balance and calm evening stress, taking it with dinner is also an effective strategy [3].

Smart Synergies & Spacing Rules

• ✓ Complementary Nutrients: Pairs exceptionally well with Omega-3 DHA (such as NOW DHA-1000), Alpha GPC, or Ginkgo Biloba for comprehensive cellular brain nutrition [1].
• ✗ Critical 2-Hour Spacing Rule: If you take fiber supplements (such as psyllium husk) or fat-binding supplements (such as chitosan), take your Phosphatidyl Serine softgel at least 2 hours apart. Insoluble fibers can bind to healthy lipids in your gut and carry them out before your body can absorb them.

Timeline of What to Expect

• Week 1 (Initial Absorption): Phosphatidylserine enters circulation and begins incorporating into cell membranes, supporting digestive comfort and subtle mental calm [4].
• Weeks 3–4 (Tissue Saturation): Brain tissue levels rise to steady-state concentrations, supporting daily working memory, faster name and word recall, and balanced stress responses [2, 3].
• Months 2–3+ (Optimal Maintenance): Sustained cellular membrane renewal promotes lasting focus, sharp cognitive processing, and durable brain cell defense as you age [1, 4].

Physical Profile, Clean Excipients & NOW's Lab Testing Standards

Delivery Format & Swallowability

NOW Extra Strength Phosphatidyl Serine is delivered in a smooth, golden-amber oval softgel. Because the active 300 mg of PS is suspended in liquid MCT oil, the softgel is compact and easy to swallow. The BSE-free bovine gelatin capsule becomes naturally slick when taken with a generous sip of water, gliding smoothly down your throat without sticking.

Natural Aroma, Taste & Color Notes

The softgel shell is completely sealed, making it virtually odorless and tasteless. Natural color variation from golden amber to rich brown may occur between production batches. This is completely normal and reflects the natural characteristics of non-GMO soy crops during different growing seasons.

Demystifying the Other Ingredients

• MCT (Medium-Chain Triglycerides) Oil: A healthy, easily digested carrier oil derived from coconut or palm kernel oil that dissolves fat-soluble PS for optimal liquid bioavailability.
• Bovine Gelatin (BSE-free): Pure, tested animal protein that forms the airtight outer capsule, protecting the delicate phospholipids from air and oxidation.
• Glycerin: A plant-based humectant that keeps the softgel shell pliable so it does not turn brittle or crack in the bottle.
• Sorbitol: A fruit-derived sugar alcohol used in tiny amounts to maintain capsule flexibility and stability.
• Water: Purified water (H₂O) used during the encapsulation process.
• Highly Refined Soy: The plant origin of this phosphatidylserine. It undergoes intensive purification that removes allergenic soy proteins, leaving pure, concentrated phospholipids.

NOW Foods Industry-Leading Lab Testing vs. Big-Box Brands

Many discount supplements found in big-box stores and online marketplaces are contract-manufactured with minimal oversight, frequently testing low on potency or testing positive for unwanted impurities. In contrast, NOW Foods operates private, state-of-the-art analytical testing facilities accredited to rigorous ISO/IEC 17025:2017 standards, staffed by over 150 chemists, toxicologists, and microbiologists. Every batch of Phosphatidyl Serine undergoes comprehensive laboratory verification:

• ✓ ICP-MS Heavy Metal Detection: Utilizing Inductively Coupled Plasma Mass Spectrometry, NOW tests every lot down to parts-per-billion (ppb) limits for toxic metals including lead, arsenic, cadmium, and mercury, ensuring compliance with strict California Proposition 65 and USP safety standards.
• ✓ HPLC Potency & Identification Assays: High-Performance Liquid Chromatography verifies that every softgel yields a true 300 mg of active Phosphatidyl Serine, guaranteeing label claim through product expiration without cheap lecithin fillers.
• ✓ GC-MS/MS & LC-MS/MS Contaminant Screens: Advanced tandem mass spectrometry screens raw materials against hundreds of agricultural pesticides, synthetic chemicals, and industrial solvents.
• ✓ Complete Microbial Screening: Every batch is tested for pathogens, guaranteeing absolute zero presence of Salmonella, Escherichia coli, and Staphylococcus aureus, alongside strict limits on yeast and molds.
• ✓ Third-Party cGMP Audits: NOW's manufacturing facilities are audited and certified for Current Good Manufacturing Practices (cGMP) by UL Solutions and the Natural Products Association (NPA).

Storage & Eco-Friendly Packaging

Store your bottle in a cool, dry place after opening, away from steam, stove heat, and direct sunlight. Keep the cap closed tightly. This bottle is proudly manufactured from 100% PCR (post-consumer recycled) resin, helping protect the environment by reducing virgin plastic waste.

Complete Supplement Facts & Retailer Verification