UPC: 733739033833
# N3383

NOW® Clinical Cardio: Targeted Cardiovascular & Arterial Support

Maintaining optimal cardiovascular vitality requires a multi-pathway strategy that addresses myocardial energy production, vascular endothelial tone, and arterial elasticity. NOW® Clinical Cardio delivers an advanced, clinically validated formula that combines bioavailable cofactors, patented botanicals, and targeted micronutrients to support cardiovascular structures and function within healthy ranges.

Engineered for Multi-Action Heart Health

Unlike generic single-ingredient heart supplements, NOW Clinical Cardio operates across three primary physiological pillars:
  • Myocardial Bioenergetics: Supplies cellular substrates to the mitochondria of cardiac muscle tissue, where continuous ATP generation is essential for healthy systolic pumping action.
  • Endothelial Function & Microcirculation: Enhances vascular nitric oxide production to help blood vessels relax and support blood pressure already within normal ranges.
  • Vascular Calcium Regulation: Promotes arterial flexibility and elasticity by directing systemic calcium out of vascular walls and into the bone matrix.

Clinically Researched Ingredients & Physiological Mechanisms

1. Carnipure® L-Carnitine Tartrate (500 mg per Daily Dose)

The human heart derives between 60% and 70% of its energy directly from fatty acid oxidation. Carnipure® L-Carnitine is a pharmaceutical-grade, pure L-carnitine that shuttles long-chain fatty acids across the inner mitochondrial membrane into the mitochondrial matrix. This fuels oxidative phosphorylation, providing continuous energy substrate to high-demand cardiac muscle fibers.

2. MegaNatural®-BP™ Grape Seed Extract (150 mg per Daily Dose)

Extracted through a patented hot-water extraction process yielding a minimum of 90% polyphenols, MegaNatural®-BP™ contains a unique, low-molecular-weight proanthocyanidin profile designed for superior bioavailability. Human clinical trials conducted at the University of California, Davis, demonstrated that MegaNatural®-BP™ supports endothelial nitric oxide synthase (eNOS) activation, encouraging vasodilation and supporting healthy blood pressure already within normal ranges.

3. MenaQ7® Vitamin K2 as MK-7 (180 mcg per Daily Dose)

Arterial stiffness often stems from inappropriate vascular calcification. MenaQ7® is a clinically backed, highly bioavailable, and long-acting form of Vitamin K2 (Menaquinone-7). MK-7 serves as the necessary cofactor for the carboxylation of Matrix Gla Protein (MGP)—the body’s primary inhibitor of soft-tissue calcification. By activating MGP, MenaQ7 helps keep arteries clear, supple, and elastic.

4. Coenzyme Q10 (CoQ10) (100 mg per Daily Dose)

CoQ10 (Ubiquinone) is an essential component of the mitochondrial electron transport chain, facilitating electron transfer between Complexes I, II, and III. Due to the myocardium's constant mechanical workload, heart tissue exhibits the highest concentration of CoQ10 in the human body. In addition to powering cellular energy production, CoQ10 provides vital lipophilic antioxidant defense against lipid peroxidation in arterial walls and circulating LDL particles.

5. Standardized Hawthorn Extract (300 mg per Daily Dose)

Derived from both leaf and flower and standardized to a minimum of 1.8% vitexin-2"-O-rhamnoside, Crataegus laevigata has a centuries-long history in European phytomedicine. Modern cardiovascular research demonstrates that hawthorn bioflavonoids inhibit cyclic AMP phosphodiesterase, exerting a mild, natural inotropic action and promoting coronary microvascular circulation.

6. Vitamin D3 as Cholecalciferol (2,000 IU / 50 mcg per Daily Dose)

Vitamin D receptors (VDRs) are widely distributed throughout the vascular endothelium, cardiac myocytes, and vascular smooth muscle cells. Adequate levels of Vitamin D3 contribute to the physiological down-regulation of the renin-angiotensin-aldosterone system (RAAS), promoting balanced fluid dynamics and vascular equilibrium.

Complete Supplement Facts & Nutritional Profile

Serving Size: 1 Veg Capsule | Servings Per Container: 90 Suggested Usage: Take 1 capsule twice daily with meals containing healthy dietary fats for optimal absorption, or as directed by your healthcare practitioner.
Active Ingredient Amount per 1 Veg Capsule Amount per Daily Serving (2 Veg Caps) % Daily Value (per Serving)
Vitamin D3 (as Cholecalciferol from Lanolin) 25 mcg (1,000 IU) 50 mcg (2,000 IU) 125% (250% Daily)
L-Carnitine (Carnipure®) (from 373 mg L-Carnitine Tartrate) 250 mg 500 mg *Daily Value not established
Hawthorn Extract (Crataegus laevigata / monogyna) (Leaf & Flower) (Std. to min. 1.8% Vitexin-2"-O-rhamnoside) 150 mg 300 mg *Daily Value not established
Grape Seed Extract (MegaNatural®-BP™) (Vitis vinifera) (Std. to min. 90% Polyphenols) 75 mg 150 mg *Daily Value not established
Coenzyme Q10 (CoQ10) 50 mg 100 mg *Daily Value not established
Vitamin K2 (as Menaquinone-7) (MK-7) (MenaQ7®) 90 mcg 180 mcg *Daily Value not established
Other Ingredients: Hypromellose (cellulose capsule), Microcrystalline Cellulose, Stearic Acid (vegetable source), and Silicon Dioxide. Allergen Specifications: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or sesame ingredients. Produced in a certified Good Manufacturing Practices (cGMP) facility that processes other ingredients containing these allergens. Quality Assurance: Non-GMO, identity verified via in-house HPLC/mass-spectrometry testing, and formulated without synthetic colorings or artificial preservatives.

Medical Precautions, Contraindications & Safety Profile

Clinical Caution & Drug Interactions: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Frequently Asked Questions (FAQ)

How does NOW Clinical Cardio support blood pressure?

NOW Clinical Cardio contains MegaNatural®-BP™, a patented grape seed extract backed by clinical research demonstrating that its low-molecular-weight polyphenols help stimulate endothelial nitric oxide production. This naturally encourages vasodilation and assists the body in maintaining blood pressure levels already within the healthy, normal range.

What makes MenaQ7® Vitamin K2 essential for arterial health?

While Vitamin D3 assists in calcium absorption, Vitamin K2 as MenaQ7® (MK-7) ensures that calcium is properly utilized. MK-7 activates Matrix Gla Protein (MGP), an essential physiological regulator that binds excess circulating calcium and prevents it from calcifying inside arterial walls, preserving long-term arterial flexibility and vascular compliance.

Why is L-Carnitine paired with CoQ10 in this formula?

L-Carnitine and CoQ10 work synergistically to support cardiac cellular bioenergetics. Carnipure® L-Carnitine acts as the molecular shuttle that carries fatty acids into myocardial mitochondria, while CoQ10 facilitates the enzymatic transfer of electrons required to convert those fatty acids into adenosine triphosphate (ATP), the primary fuel for heart contractions.

How long should I take NOW Clinical Cardio before noticing benefits?

Nutritional and botanical cardiovascular support functions through cellular remodeling and vascular antioxidant balance. While cellular uptake begins immediately, human clinical studies evaluating ingredients like MegaNatural®-BP™ and MenaQ7® typically demonstrate optimal vascular and arterial benefits after 4 to 8 weeks of consistent daily usage.

Can I take NOW Clinical Cardio alongside prescription blood thinners?

No. NOW Clinical Cardio provides 90 mcg of Vitamin K2 (MK-7) per capsule (180 mcg daily). Vitamin K is known to counteract Vitamin K antagonist anticoagulants such as Warfarin (Coumadin). Always consult your cardiologist or prescribing physician prior to starting this supplement if you are taking any blood-thinning or cardiac medication.

When is the best time to take NOW Clinical Cardio?

The recommended protocol is 1 veg capsule twice daily, taken with morning and evening meals. Taking the capsules with food containing dietary fats significantly enhances the intestinal absorption of fat-soluble cofactors, specifically CoQ10, Vitamin D3, and Vitamin K2.

Is NOW Clinical Cardio vegan, non-GMO, and gluten-free?

NOW Clinical Cardio is encapsulated in vegetable cellulose (hypromellose) capsules, is non-GMO, and contains no wheat, gluten, soy, milk, egg, fish, shellfish, or sesame ingredients. Note that the Vitamin D3 is derived from lanolin (sheep's wool), making it suitable for vegetarians, though strict vegans may choose a purely plant-sourced D3 formula.
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