ChromeMate® Chromium GTF 200 mcg Yeast Free by Source Naturals provides a clinically recognized,
biologically active form of trivalent chromium (Cr3+) complexed with niacin (nicotinic acid). Chromium is an essential
trace mineral required for normal macronutrient metabolism and cellular energy production. In the human body, chromium
functions as an integral component of the Glucose Tolerance Factor (GTF), an endogenous physiological complex
that potentiates the activity of insulin to shuttle blood glucose into peripheral cells.
Unlike conventional yeast-derived GTF supplements, this advanced formulation is 100% yeast-free, making
it the preferred choice for individuals with dietary yeast sensitivities, Candida albicans susceptibility, or
allergies. Each tablet delivers 200 mcg of elemental chromium as patented ChromeMate® chromium polynicotinate,
yielding superior systemic absorption and prolonged tissue retention compared to inorganic chromium salts.
Key Physiological Benefits of Niacin-Bound Chromium
Enhanced Insulin Sensitivity: Amplifies insulin receptor tyrosine kinase activity, facilitating
smooth glucose transport across cell membranes and helping balance postprandial blood sugar spikes.
Metabolic Energy & Craving Control: Promotes balanced cellular uptake of carbohydrates, proteins,
and lipids, reducing afternoon energy dips and mitigating intense sugar and carbohydrate cravings.
Patented ChromeMate® Polynicotinate Matrix: Features an oxygen-coordinated 1:2 chromium-to-niacin complex,
providing greater bioavailability and cellular uptake than standard chromium chloride or generic chromium picolinate.
100% Yeast-Free Formulation: True GTF biological activity synthesized without brewer’s or baker’s
yeast, ensuring gastrointestinal comfort and safety for yeast-sensitive regimens.
Supports Healthy Lipid Profiles: Clinical literature suggests optimal chromium status contributes
to maintaining total cholesterol, LDL, and triglyceride levels already within the normal reference range.
The Science Behind GTF: Why Niacin-Bound Chromium Matters
The concept of Glucose Tolerance Factor (GTF) was first characterized by Dr. Walter Mertz, who isolated a natural
dietary factor essential for restoring normal glucose tolerance in animals. Biologically, dietary trivalent chromium acts
through an oligopeptide known as chromodulin (low-molecular-weight chromium-binding substance). When insulin
binds to cell-surface receptors, chromodulin captures circulating chromium ions, changes conformation, and binds to the
internal tyrosine kinase domain of the insulin receptor, amplifying intracellular signaling and facilitating GLUT-4 glucose
transporter translocation.
Chromium Polynicotinate vs. Chromium Picolinate
While chromium picolinate binds chromium to picolinic acid, ChromeMate® binds chromium to niacin (vitamin B-3).
Comparative pharmacokinetic studies indicate that niacin-bound chromium is absorbed significantly better by red blood cells
and target tissues, is cleared more steadily through the kidneys, and exhibits significantly lower cellular toxicity profiles
than inorganic or picolinate complexes.
Complete Supplement Facts & Ingredient Profile
Serving Size: 1 Tablet | Servings Per Container: 120
Microcrystalline cellulose, dibasic calcium phosphate, stearic acid, and magnesium stearate.
Allergen & Dietary Information
Suitable for Vegetarians. Contains NO yeast, dairy, egg, gluten, corn, soy, or wheat.
Formulated without sugar, starch, artificial preservatives, synthetic dyes, artificial flavors, or fragrances.
Suggested Use & Protocol Guidelines
Directions: Take 1 tablet 1 to 2 times daily with meals, or as professionally recommended by your
physician or clinical nutritionist. Taking chromium with food enhances gastrointestinal tolerance and syncs chromium
availability with normal postprandial glucose dynamics.
Important Health & Medication Precautions
Diabetic & Hypoglycemic Precautions: Chromium enhances physiological insulin sensitivity. If you are
taking prescription insulin, metformin, sulfonylureas, or GLP-1 receptor agonists, monitor your blood glucose closely.
Dosage adjustments must be overseen by your prescribing physician to prevent unintended hypoglycemia.
Pregnancy & Nursing: If you are pregnant, planning to become pregnant, or lactating, consult your
healthcare provider before using this supplement.
Drug Interactions: Concurrent use with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase
chromium absorption, whereas antacids, proton pump inhibitors (PPIs), and corticosteroid medications may alter mineral
bioavailability or excretion.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to
diagnose, treat, cure, or prevent any disease.
Frequently Asked Questions (FAQ)
What makes Source Naturals ChromeMate® different from ordinary chromium supplements?
ChromeMate® utilizes a patented complex that chemically bonds trivalent chromium with bioavailable niacin (vitamin B-3).
This structural configuration mirrors the biological Glucose Tolerance Factor (GTF) found naturally in human tissue,
providing significantly higher absorption and cellular utilization than common inorganic forms such as chromium chloride.
Why is a "Yeast-Free" GTF chromium formula important?
Traditional GTF chromium was historically derived from brewer's yeast (Saccharomyces cerevisiae). However,
many individuals have yeast allergies, celiac/gluten sensitivities, or gastrointestinal dysbiosis such as
Candida overgrowth. Source Naturals ChromeMate® provides biologically active GTF activity synthetically complexed
without any yeast organisms or yeast by-products.
Can I take this supplement if I am on prescription blood sugar medication?
You must consult your endocrinologist or primary healthcare provider prior to use. Because chromium polynicotinate improves
cellular insulin efficiency, combining it with medications like insulin, glipizide, or metformin could trigger hypoglycemia
(excessively low blood sugar). Your physician may need to calibrate your prescription dosages.
What is the optimal time of day to take ChromeMate Chromium GTF 200 mcg?
It is recommended to take 1 tablet with your largest carbohydrate-containing meals (such as breakfast and dinner).
Administering chromium alongside meals optimizes nutrient uptake and assists insulin during active postprandial glucose
processing.
Does 200 mcg of chromium exceed the recommended daily dietary intake?
While 200 mcg represents 571% of the basic Daily Value (DV), this dosage is standard in targeted clinical nutrition.
The Institute of Medicine has not established a Tolerable Upper Intake Level (UL) for trivalent chromium due to its high
margin of physiological safety and low absorption rate of excess unneeded ions.
'Chromium is a trace element that works with insulin to help facilitate the uptake of glucose into cells.
The National Research Council has established the need for chromium in humans nutrition.
Only 1 tablet twice a day needed.
Do not use if tamper evident, or if protective seal is broken or missing
