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Cinnamon and Blood Sugar

old message Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic Darrell Miller 05/18/05
old message Additional Supplements to lower Blood sugar. Darrell Miller 05/18/05
old message Fenugreek and Cinnamon to lower blood sugar ... Darrell Miller 05/18/05


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Date: May 18, 2005 09:20 AM
Author:
Subject: Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic

Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.

Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a model of genetic hypertension. Material and Methods: Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.

Results: We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major differences were in the types and proportions of individual oils contributing to a given formula.

Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity. Keywords: diabetes mellitus, essential oils, insulin resistance, insulin sensitivity, insulin sensitivity, natural products Received 11 August 2003; returned for revision 25 September 2003; revised version accepted 16 March 2004 Introduction The prevalence of insulin resistance and its most severe form type 2 diabetes mellitus is rapidly increasing in the USA – even throughout the world [1–3]. The recent increase is attributed, at least to some extent, to the greater occurrence of overweight and obesity that is due mainly to an augmented intake of calories and refined carbohydrates, lesser consumption of fibres and a more sedentary lifestyle [4–6]. Obviously, reversal of these situations should ameliorate the problem. Unfortunately, more is often needed than simply advising lifestyle changes that frequently fail in order to combat insulin resistance and its accompanying perturbations (cardiovascular diseases, obesity, dyslipidemias, diabetes mellitus and premature ageing) [7,8]. Experience shows that the afflicted not infrequently require aids to help with the maintenance of a healthful lifestyle. Correspondence: Harry G. Preuss, D, Georgetown University Medical Center, Department of Physiology and Biophysics, Basic Science Building, Room 231B, 4000 Reservoir Road, N.W., Washington, DC 20057, USA. O R I G I N A L ART I C L E doi: 10.1111/j.1463–1326.2004.00386.x # 2004 Blackwell Publishing Ltd Diabetes, Obesity and Metabolism, 7, 2005, 193–199 193

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    Date: May 18, 2005 09:24 AM
    Author:
    Subject: Additional Supplements to lower Blood sugar.

    example, supplementary niacin-bound chromium [20,21], garlic [22], soluble fibres [23] and vanadium [24] can overcome, to some extent, many of these perturbations. Thus, natural nutrients/elements have the potential to favourably influence the glucose/insulin system and the onset of age-related chronic disorders with little threat of serious adverse side effects [1]. We should mention that it is possible that proper combinations of these natural products may give even better risk/benefit ratios than single agents alone.

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    Date: May 18, 2005 09:27 AM
    Author:
    Subject: Fenugreek and Cinnamon to lower blood sugar ...

    Fenugreek and cinnamon have had extensive studies devoted to their anti-diabetic properties. The major action of fenugreek may be via blockage of glucose absorption [35]. Cinnamon has been shown to have insulin-like action [38] and affect insulin signalling [39]. There is little association of diabetes treatment with cumin, pumpkin seed and oregano [35], although animal studies do suggest that cumin may lower circulating lipid levels in diabetic rats [40]. The long-term safety of these condiments in the food supply suggests the possibility of daily use over the long haul to prevent or ameliorate insulin resistance and perhaps even increase useful lifespan [1,41]. Previous studies with other natural products have suggested this potential [42]. Future studies are necessary to test the veracity of this hypothesis.

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