Date: July 13, 2005 09:42 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: WHAT EXACTLY IS PYCNOGENOL?

WHAT EXACTLY IS PYCNOGENOL?

Pycnogenol is a super antioxidant which consists of a highly bioavailable flavonoid called proanthocyanidin. This compound can be extracted from either pine bark or grape seed, and both sources are virtually identical. Biochemists will confirm that as a class, the proanthocyanidin bioflavonoids, regardless of their source, possess the same biochemical activity with very slight exceptions.

The differences lie in the varying concentrations of the flavonoid and its purity. Extraction processes for each source d i ffer and may contribute to the cost of the type of Pycnogenol in question. Regardless of its source, Pycnogenol has demonstrated extraordinary antioxidant capabilities.

NATURE’S BEST DEFENSE AGAINST FREE RADICALS: ANTIOXIDANTS

Potent substances called antioxidants, which scavenge for dangerous free radicals, afford us the best prospect for disease prevention, toxin protection and sustained longevity and vigor. According to many experts, making sure we arm our cellular systems with adequate supplies of antioxidants should be our first health priority. “It has now been established that more than 60 human diseases involve free-radical damage, including cancer, heart disease and the acceleration of the aging process. All that you really need to know is that your body is under constant free - radical atta ck, and that you need to keep your antioxidant defenses strong.”1 The role of Pycnogenol as an exc e ptional free radical scavenger is just beginning to emerge, and the protective potential of Pycnogenol is impressive, to say the least. It’s only a matter of time before scientific data supports the fact that this family of nutrients is far more effective in its antioxidant capacity than previously assumed.

OTHER ANTIOXIDANTS

Some of the most common of free radical scavengers or antioxidants include:

While all of these are excellent cellular protectants, the compound missing from the above list may be the most remarkable of all.

PYCNOGENOL: THE HERCULES OF ANTIOXIDANTS

Pycnogenol provides some of the most potent compounds known to nutritionally support and potentiate the body’s defense system against oxidants. Continually emerging research supports the fact that Pycnogenol may be the best antioxidant nature has to offer. In this regard, it is 50 times more potent than vitamin E and 20 times more so than vitamin C.2 Pycnogenol is considered by some health experts to be the greatest nutritional breakthrough of our century.

Date: July 13, 2005 09:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: WHAT IS A FREE RADICAL?

WHAT IS A FREE RADICAL?

Free radicals are unstable, unpredictable structures that pose a potential threat to healthy molecules on a cellular level. In their atte mpt to become stable, they assault and randomly impact healthy molecules, altering their functions in the process.

TO COMPLETLEY ELIMINATE FREE RADICALS, YOU MUST STOP BREATHING

The very act of breathing oxygen activates these reactive chemical structures. To make matte rs wo rse, because our generation, more than any other, is exposed to a number of potentially harmful environmental substances, free radical formation can reach epidemic proportions. Some of the more dangerous of these include:

EVEN EXERCISE HAS ITS PERILS

Exercising, as beneficial as it is, can initiate the release of free radicals within our cellular systems. Aerobic exercising produces oxidation products. Many of these compounds are not neutralized by our internal safety mechanisms and an overload can occur. Supplementing the diet with efficient antioxidants is highly recommended for eve ryone, but especially for those who exercise on a regular basis.

WHY ARE FREE RADICALS SO DANGEROUS

A free radical can destroy a protein, an enzyme or even a complete cell. To make matte rs wo rse, free radicals can multiply through a chain reaction mechanism resulting in the release of thousands of cellular oxidants. When this happens, cells can become so badly damaged that DNA codes can be altered and immunity can be compromised.

Contact with a free radical or oxidant on this scale can create cellular deterioration, resulting in cancer and heart disease. Tissue breakdown from this oxidative stress can also occur which can contribute to aging, arthritis and whole host of other degenerative conditions. “Through free radical reactions in our body, it’s as though we’re being irradiated at low levels all the time. They grind us down.”3

PREMATURE AGING AND FREE RADICALS:

Frequently, the oxidative stress caused by free radicals results in what we refer to as the aging process. While aging is inevitable, many of us hasten its outcome by not protecting ourselves, hence, we age prematurely. The early onset of wrinkling, arthritis, circulatory disorders, diabetes, heart disease and hardening of the arteries can result from free radical damage that could have been minimized by consistently taking strong antioxidants like Pycnogenol. More and more research suggests that it is a lack of certain protective nutrients, like the bioflavonoid compounds contained in Pycnogenol, which increases our risk of cancer and other degenerative diseases.4

WHY A NUTRITIOUS DIET DOES NOT AFFORD US ENOUGH PROTECTION

“They (antioxidants) may be much more important that doctors thought in warding off cancer, heart disease and the ravages of aging—and, no, you may not be getting enough of these nutrients in your diet.”5

Clearly, while diet modifications are invaluable, diet alone cannot provide the kind of physiological defense the body requires to inhibit free radicals before they cause biological harm. While there is no way to escape our exposure to free radicals, we can minimize potential cellular destruction by reducing their numbers.

Date: July 13, 2005 12:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: PROANTHOCYANIDINS MAKE PYCNOGENOL SO EXTRAORDINARY

PROANTHOCYANIDINS MAKE PYCNOGENOL SO EXTRAORDINARY

Recently, the very profound effect of the proanthocyanidins found in Pycnogenol has been investigated for its remarkable antioxidant action. These bioflavonoid compounds have been found to significantly surpass other known antioxidants in their ability to scavenge free radicals. Pycnogenol is 50 times more potent than vitamin E and 20 time more so than vitamin C. In addition, it is one of the few compounds that can cross the blood- brain barrier making it therapeutically effective for a number of neurological disorders.

Date: July 13, 2005 09:48 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: THE ORIGINS OF PYCNOGENOL

THE ORIGINS OF PYCNOGENOL

For generations, certain tribes of North American Indians used bioflavonoids extracted from the bark of pine trees for a variety of disorders. Because of its marvelous healing properties, they called this pine the Annedda, or “tree of life.”

PINE BARK: GIVER OF LIFE

These native Americans, who routinely ate deer as their primary source of nutrition, when confronted with a scarcity of meat asked themselves ... where does the deer get its strength? They discovered that deer stripped away pine tree bark and we re able to derive life-giving nutrients from its organic composition. It was also observed that devastating diseases such as scurvy did not afflict those who ate the bark, leaves or needles of this pine tree.

CARTIER’S ENCOUNTER WITH ANNEDDA TEA

In 1535, Jacques Cartier learned of the medicinal value of the bark, which remained relatively unknown until 20 or 30 years ago, when scientists reviewed his notes and commenced research. Cartier became caught in the bitter snows of Quebec, while attempting to navigate the St. Lawrence River. Cartier and his crew subsisted on hard biscuits and cured meat and eventually came down with what was believed to be scurvy. Scurvy is an abhorrent disease which causes a very slow and agonizing death. Several of Cartier’s men died before they were approached by the Quebec Indians who prepared a tea they called “Annedda” from the bark of a certain native pine tree. The men took the tea and used its leaves as poultices. Their recovery was almost immediate. What must have seemed like a miraculous substance was technically, nothing more than vitamin C with bioflavonoids naturally inherent to the pine tree.

MASQUELIER’S SUBSEQUENT DISCOVERY OF PYCNOGENOL

Cartier was resourceful enough to document the incident. Over 400 years later, a French professor, Jacques Masquelier, assigned to the University of Quebec discove red Cartier’s account. Because he was already involved in bioflavonoid research, he became greatly intrigued by pine tree extract. Dr. Masquelier isolated a bio-active substance known as proanthocyanidin.

THE EMERGENCE OF PROANTHOCYANIDIN

After returning to France, Professor Masquelier found that this compound could be extracted from the bark of the French Maritime Pine pinus maritima found in abundance in southern France. Intensive research by Dr. Masquelier led to the discovery of Pycnogenol, which is another name for the group of bioflavonoids known as the proanthocyanidins. Subsequent in-depth testing revealed that these compounds are a nutrient treasure far more valuable that anyone originally thought. In time, the grape seed was found to contain the same compound and today, is considered an excellent source of Pycnogenol in France.

Date: July 13, 2005 10:01 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: PYCNOGENOL AS A DIETARY SUPPLEMENT

PYCNOGENOL AS A DIETARY SUPPLEMENT

While flavonoid concentrates were used in ancient times to treat a variety of human diseases, modern medicine has failed to utilize their enormous therapeutic potential. We assume RDA standards to provide us with all the vitamin C and bioflavonoids we need to be healthy. Even if these set quantities were accurate for maintaining optimal health, how many of us eat diets nutritious enough to maintain maximum health and protection? In other words, do we consume enough fruits and ve g etables to affo rd us adequate levels of vitamin C and bioflavonoids to provide the free radical protection we need?

“The USDA conducted a study in which they collected dietary information over the course of the year for four independent days. In that study 20% of the adult women had no fruit or juice for four days, and about 45% had no citrus fruit or citrus fruit juice in four days.”6

MALNUTRITION IN THE MIDST OF PLENTY?

Only 9% of our population gets and eats enough fruits and vegetables on a consistent basis. Unquestionably, most of us are not getting enough vitamin C and flavonoid compounds from our diets.

In addition, it’s important to remember that modern farming techniques, pre m a t u re harve sting of fruits and vegetables, indefinite cold storage, freezing, canning and cooking may denature food of its vitamin C and bioflavonoid content. Because we know that diseases are often nothing more than nutritional deficiencies, we must make adequate supplementation a priority if we want to enhance our longevity.

As mentioned earlier, biofl avonoids must combine with vitamin C (ascorbic acid) in order to be effective. Mother nature was well aware of this synergistic relationship, as most plant biof l avonoids accomp a ny vitamin C compounds. In addition, the best, most bio-active and bioavailable flavonols must be chosen for their antioxidant properties. An overwhelming consensus exists that Pycnogenol may be the ideal choice.

Date: July 13, 2005 12:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: PYCNOGENOL - ITS REMARKABLE BENEFITS

PYCNOGENOL - ITS REMARKABLE BENEFITS

New to North America but not to Europe, this natural product is considered safe and effective in the treatment of various diseases and for the maintenance of optimal health. This family of bioflavonoids is non-toxic, water soluble and highly bioavailable. Because proanthocyanidins scavenge free radicals so effectively, they have shown remarkable curative effects. Extensive research demonst rates that proanthocyanidins are such potent antioxidants, they find and neutralize free radicals with great rapidity, allowing cells to regenerate rather than deteriorate. Specific actions associated with Pycnogenol include:

PYCNOGENOL SPECIFICALLY TARGETS: SKIN AND ELASTICITY

Testing has suggested that Pycnogenol flavonoids exhibited an anti-enzyme effect which prevented the break down of collagen and elastin, the very compounds which keep skin firm and inhibit the formation of wrinkles.7

TUMOR RELATED DISEASES

Unquestionably, studies have shown that Pycnogenol has the ability to inhibit cellular mutations.8 The implications of this finding for anyone suffering from tumor related disease which originates from cellular malfunctions should not be underestimated.

CARDIOVASCULAR CONDITIONS

The potential of Pycnogenol to pr e vent cellular deterioration or uncontrolled growth is profound to say the least. Several investigations have shown that if it is taken on a daily basis, Pycnogenol benefits people suffering from cardiovascular diseases and breast tumors.9 In addition, double blind placebo controlled studies have indicated that patients suffering from circulatory insufficiencies and diseases of the lymph system showed significant improvement in pain control and vessel elasticity after taking these flavonoids.10

VISION

Subsequent experiments concluded that the family of bioflavonoids contained in Pycnogenol is capable of improving night vision and initialing “a rapid and marked improvement of visual performances after glare in comparison with control group.”11

WATER RETENTION AND EDEMA

Pycnogenol is particularly valuable for anyone who suffers from water retention and edema. Studies at the Institute of Physiology at the Bulgarian Academy of Sciences confirm that this biofl avonoid compound stabilized capillary walls, which decreased fluid leakage into tissues which causes swelling and pressure.12

WHAT PATHOLOGICAL CONDITIONS RESPOND TO PYCNOGENOL?

The bioflavonoids found in Pycnogenol have been clinically indicated in the following pathological conditions:

PYCNOGENOL HAS THERAPEUTIC VALUE FOR THE FOLLOWING CONDITIONS:

PYCNOGENOL CAN CROSS THE BLOOD-BRAIN BARRIER

One of the most significant advantages of this flavonoid compound is its ability to cross the blood-brain barrier. Consequently, it acts as an invaluable therapeutic agent in treating depression, chronic fatigue, insomnia or loss of memory.

ANTI-ULCER FORMING PROPERTIES

Other scientific tests have indicated that proanthocyanidins also posses anti-ulcer properties and may work to prevent the formation of undesirable chemicals in the stomach.13

Date: July 13, 2005 12:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HOW BIOAVAILABLE IS PYCNOGENOL?

HOW BIOAVAILABLE IS PYCNOGENOL?

The results of isotopic testing confirmed that grape seed proanthocyanidins had a specific affinity for collagen, and demonstrated how long the bioflavonoid complex adhered to living tissue. Because this testing was not possible on pine bark sources of proanthocyanidins, data collected from grape seed testing has been extrapolated or applied to pine bark. Pycnogenol is rapidly absorbed and transported throughout the cellular system due to the high water solubility of the proanthocyanidins. Within one hour of ingesting this bioflavonoid complex, proanthocyanidins can be detectedin human saliva. Pycnogenol uptake in the body is rapid and is quickly distributed.

The bot tom line is that Pycnogenol is a water-soluble bioflavonoid which is quickly assimilated after ingestion into the bloodstream. There, it acts to scavenge free radicals and to strengthen connective tissue. The proanthocyanidins found in Pycnogenol can not only scavenge and remove free radicals, but inhibit their propagation as well.

THE TOLERABILITY AND SAFETY OF PYCNOGENOL

It would certainly be pointless to find a substance that while seemingly beneficial, was not safe or could not be well tolerated by its users. Studies have shown that pure sources of Pycnogenol are practically devoid of any oral toxicity. Even extremely high dosages administered over sustained periods of time showed no toxicity or side-effects.14 Virtually no actual or potential risks were found with this compound. Pycnogenol has been shown to be safe for conception, pregnant women, and the unborn fetus. It is devoid of any perior postnatal toxicity. On the contrary, the compounds were found to not only benefit targeted disorders, but a variety of other conditions improved as well.

Date: July 13, 2005 12:35 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: PROPER DOSAGES OF PYCNOGENOL CAN DETERMINE ITS EFFECTIVENESS

PROPER DOSAGES OF PYCNOGENOL CAN DETERMINE ITS EFFECTIVENESS

Some doctors who have used Pycnogenol recommend a dose of 20 mg. for every 20 lbs. of body weight to obtain optimal results. This usually averages to approximately 150-200 mg. per person, per day. For therapeutic doses, a saturation level can be obtained by taking an increased amount of Pycnogenol initially and then tapering off to optimal body weight dosages.

PYCNOGENOL: LIFE-CHANGING COMPOUND

Supplementing the diet with nature’s most powerful antioxidants is certainly paramount in protecting ourselves and our families from the ravages of disease. Studies suggest the earlier we sta rt using Pycnogenol, the better for our biocellular health. While we anxiously await for the cure for cancer and other devastating diseases, we can arm our bodies with the most powerful protective nutrients available. Pycnogenol is the compound of choice.

A WORD CONCERNING TESTIMONIALS

Frequently, sensational claims emerge when new health supplements are introduced. Concerning Pycnogenol, accounts vary from anecdotal to scientific. Unquestionably, when it comes to vision problems, capillary weakness, prostate problems or any type of inflammatory problem, Pycnogenol has already compiled an impressive track record.

Date: July 13, 2005 12:39 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SUMMARY OF SPECIFIC ACTIONS ASSOCIATED WITH PYCNOGENOL

SUMMARY OF SPECIFIC ACTIONS ASSOCIATED WITH PYCNOGENOL

A REMARKABLE PREDICTION

The general consensus among many experts in the health field is that Pycnogenol is destined to become the most vital of all antioxidant compounds. As more scientific evidence presents itself, Pycnogenol may eventually sweep 21st century dietary supplementation.

Date: July 13, 2005 09:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: THE THERAPEUTIC PROPERTIES OF PYCNOGENOL

THE THERAPEUTIC PROPERTIES OF PYCNOGENOL

Pycnogenol provides extraordinary therapeutic benefits for a number of physiological conditions and has even contributed to the reversal of some disease states. The active compound found in Pycnogenol acts as a highly potent free radical scavenger, and can not only improve overall health, but protect it as well.

The proanthocyanidins contained in Pycnogenol may well become the most important nutritional breakthrough of the 21st century. They may prove to be the most potent and effective compounds which act to protect against the cellular damage caused by free radicals discovered to date.

Date: July 13, 2005 12:42 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: References

ENDNOTES

1 Time Magazine, (April 6, 1992).
2 Indena Fact Sheet, # 16.
3 The New York Times. (April 25, 1993).
4 Jon J. Mich n ovicz, M.D., Ph.D. H ow to Reduce Your Risk of Breast Cancer, (New York: Warner Books, 1994), 103.
5 Richard A. Passwater Ph.D., Cancer Prevention and Nutritional T h e ra p i e s, (New Canaan, Connecticut: Keats Publishing, 1993).
6 G. Block, University of Southern California at Berkeley
7 “ L e u c o a n t h o c yanins Extract From Grapeseeds (Vins Vinifera),” Indena Publication
8 Liviero, International Symposium on Phytochemistry of Plants Used in Traditional Medicine.
9 R.I. Rayer, and C. L. Schmidt, Seminary Hospital, (Paris: 1981), 57, 2009 and Indena International Report (Data on File). 10 J . F. Thebaut, P. Thebaut and F. Vin, Gazet te Medicale, (1985), 92, 96.
11 L. Fusi, F. Czimeg, F. Pesce, R. Germagli, A. Boero, M. Vanzetti, G. Gandiglio, Ann Ott Clin, Ocul, (1988) 114, 575.
12 D. Zafirov, G. Bredy-Dobreva, V. Litchev, M. Papasovasvie, Ac ta Physiol Pharmacol, Inst i t u te of Phys i o l o g y, Bulgarian Academy of Sciences, (Sofia, Bulgaria: 1990) 16 (3) 50-54.
13 B. Vennet, “Anti-ulcer Activity of Procyanidin Preparation of Wa ter Soluble Pro c yanidin Cimetidine Comp l exes,” Pharm Acta Helv, (Switzerland: 1989), 64 (11) 316-20
14 “Leucoanthocyanins Extract From Grapeseed (Vins Vinfera)” Indena Publication.

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Vitanet ®

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