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Vitaberry Plus + Super Fruit Antioxidant |
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Vitaberry Plus + Super Fruit Antioxidant
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Darrell Miller | 12/07/05 |
Date:
December 07, 2005 05:43 PM
Author: Darrell Miller
(dm@vitanetonline.com)
Subject: Vitaberry Plus + Super Fruit Antioxidant
Vitaberry Plus +™ Super Fruit Antioxidant
By Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),- Catalase (neutralizes peroxides),
- Functions similar to reduced Glutathione (GSH),
- Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent),
- Functions similar to Glutathione S-transferase (GST),
- Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/
ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697
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