Search Term: " Asked "
Can CBD oil help with pain, and can raisins really help you sleep?
March 09, 2019 09:44 AM
1.There is scientific support for the use of cannabis-based medicines to manage chronic pain. However, medicinal marijuana is not availabe in all states. Where it is not available, some are using CBD oil as an alternative. CBD is cannabidiol, a compound derived from cannabis. 2.Hot compresses are sometimes prescribed to treat a condition called blepharitis, which affects the eyelids. It can be difficult to keep a hot compress hot for more than a short time. Hand warmers and reheatable Dry Eye Relief Masks are a good alternative. 3.Eating a handful of raisins before bedtime can reduce the number of bathroom trips during the night.
"I live in an upscale retirement community, and a large number of people here are using marijuana oil to relieve pain without side effects."
Read more: https://www.seattletimes.com/life/wellness/pharmacy-marijuana-senior-citizens/
Supplementing with chlorella can hasten recovery from intensetraining and exercise
January 11, 2019 01:49 PM
High impact and strenuous training or lifestyle takes its toll on the body. One area that has a highly impacted rate of declined performance is that of the immune system. Lower immune system function can happen not only with the physical stress of training , work outs or lifestyle, but mental stress as well. Chorella is a micro marine algae that has several minerals and vitamins that help to repair the system as well as act as a detoxification vehicle.
"Researchers in England aimed to evaluate the effects of chlorella supplementation on salivary sIgA in response to a two-day intensive training exercise."
Read more: https://www.naturalnews.com/2018-12-27-supplementing-with-chlorella-can-hasten-recovery-from-intense-training-and-exercise.html
Vitamin C: The Immune-Boosting, Skin-Supporting Nutrient You ShouldBe Getting Plenty Of
December 17, 2018 12:59 PM
No nutrient is quiet as important as Vitamin C. It's a power-packed immune-boosting powerhouse that is found in oranges and other citrus fruits, and many other foods. When the body gets an adequate supply of Vitamin C, it thrives in more ways than one and you will look and feel your best. So while there are many nutrients that your body needs, it is important to put special emphasis on vitamin C and the positive attributes it can bring into your life.
"A very interesting study from last month demonstrated that in diabetes-induced rats who showed depression-like behavior, giving vitamin C helped with the depression, especially if blood sugar and insulin levels were also regulated."
Read more: https://www.mindbodygreen.com/articles/vitamin-c-health-benefits-side-effects-and-dosing
6 Natural Remedies To Cleanse Your Congested Colon
February 10, 2018 03:59 PM
The colon is part of the digestive system whose function is to assimilate the nutrients of food, however, due to poor eating habits, this organ houses a large amount of toxic material that eventually wears it and generates health consequences; In this sense it is very important to consider healthy practices to improve the functioning and restore the health of this vital organ, such as drinking between 10 and 12 glasses of water and if it has a high level of alkalinity, excellent; the consumption of seeds of linanza provides a high content of fiber and omega3, the juice of lemon contributes with its detoxification and the consumption of plums helps its mobility. Finally these simple habits, can improve the health and life of your colon .
"It just so happens that one of the most effective ways to cleanse and detoxify your colon is also one of the easiest: drink more water!"
Read more: https://www.thealternativedaily.com/6-natural-remedies-cleanse-congested-colon/
Ask the Expert: What are the symptoms of inflammatory bowel disease?
January 31, 2018 07:59 AM
A question about the symptoms of inflammatory bowel disease is asked. The person asking the question is unknown, the expert answering is Dr. Brian Behm a gastroenterologist. Inflammatory bowel disease (IBD) is defined as chronic inflammation of the intestines.
The difference between Crohn's disease and ulcerative colitis is discussed.
No cure is available. Lifestyle changes and diet modification can control the inflammation. These are not completely successful.
Treatment options are steroids, immunomodulators biologic medicines and aminosalicylates.
"The two main types of IBD are ulcerative colitis and Crohn's disease."
Read more: http://www.dailyprogress.com/lifestyles/ask-the-expert-what-are-the-symptoms-of-inflammatory-bowel/article_316678e6-0218-11e8-96d9-579ea5f1643b.html
Can your dog be arrested for using a cannabis extract?
December 16, 2017 03:59 PM
Thomas McDermott, a Democrat and the Mayor of Hammond, Indiana, brought up the legality of using cannabidiol oil (CBD) for treating his Labrador retriever's arthritis at the BGD Legislative Conference in Indianapolis. At the conference was Republican Indiana Attorney General Curtis Hill who last month stated that the use of CBD was illegal in most circumstances in his state after a bill passed to allow epilepsy patients to legally use the oil for seizures. McDermott questioned Hill using a story about his dog that suffered from arthritis, noting that his vet recommended using CBD oil to treat the pain. He mentioned that the oil allowed his dog to move around more easily, had more energy, and had improved appetite. McDermott thought aloud that Hill was "grandstanding" on CBD, but Hill simply stated he was following the law as it was written. When McDermott asked if his dog was breaking the law, Hill responded that the Mayor himself was breaking the law - not the dog. McDermott was upset afterwards that Hill accused him for being a criminal for treating his dog with CBD, and he has no plans to change the therapy for his dog.
"The question Thomas McDermott wanted answered Wednesday doesn’t get asked often during policy discussions in Indiana: Could his Labrador retriever be breaking the law by using a pain remedy extracted from cannabis?"
Read more: https://www.indystar.com/story/news/2017/12/13/can-your-dog-arrested-using-cannabis-extract/949429001/
Is C-Reactive Protein Secretly Making You Gain Weight?
June 08, 2017 09:14 AM
C-reactive protein or CRP is something that your liver increases production in when your body has increased inflammation as a result of high levels of stress, a lack of sleep or other symptoms. Inflammation is a direct cause of weight gain and in some cases, obesity. When inflamed, your body does things to deal with it, including storing more calories and slowing down your metabolism. Scientists found a common link between c-reactive protein and obesity, mostly in women.
"Here, we've asked experts to break down what's to blame for c-reactive protein in your blood, what it says about your weight, and what you can do to fight back."
Read more: http://www.womenshealthmag.com/weight-loss/c-reactive-protein
Greatist: Your Ideal Weight Isn't What You Think
February 18, 2017 02:59 PM
Many people have attempted dieting with a goal weight in mind, But is physical and mental health a factor in this. Science is unable to tell you what you should weigh they can only give you a generalization with body mass index. What really matters is that your are taking in enough calories and exercising a healthy amount. This along with good sleeping habits can keep you from going hopping on and off the scale often.
"Your BMI tells you almost nothing about your nutritional status, body fat percentage, or strength, and therefore tells you almost nothing about how healthy you are (or aren’t)."
Want to be smarter and have a better memory? Eat foods rich in this
December 30, 2016 12:59 PM
According to a study by the University of Illinois, eating foods rich in lutein like many leafy greens and cruciferous vegetables, for example, will help promote a healthy aging brain. The study did not specify the amount of lutein that is needed for ultimate brain protection and only concluded that more levels of the vitamin meant a better chance at brain health preservation. If your brain health is poor, Collingridge says it could lead to other serious neurological conditions like developmental disorders right through to dementia.
"Smoking can cause illnesses that contribute to memory loss, including stroke and hypertension. Smoking also constricts the blood vessels to the brain, depriving it of oxygen and possibly harming neurons."
Reducing salt intake may help protect kidney patients’ heart and kidney health
December 03, 2016 02:59 PM
Chronic kidney disease is a serious condition. One of the most detrimental effects of the disease is albuminuria. In most patients, this effect can be controlled by kidney medications. In some, however, albuminuria cannot be reduced. A recent study in which 45 patients were Asked to reduce their sodium intake, take paricalcitrol, or both showed promising results in significantly reducing albuminuria. Reducing salt intake alone helped, but combining both salt reduction and paricalcitrol provided the best results.
"The investigators found that dietary sodium restriction led to a significant reduction of residual albuminuria and blood pressure, whereas paricalcitol had no significant effect on these measures. The combination of paricalcitol and a low sodium diet, however, resulted in the lowest albuminuria levels."
The diet habits you need to change immediately
November 28, 2016 04:59 PM
We have grown up being told to take changes gradually in order to build a better support system. We are taught that sudden or extreme changes are harder to maintain and may harm us in the end. A study from the University of California is contesting that belief. They had participants spend 5 hours a day committing to healthy habits such as exercise or taking wellness classes. The researchers noticed that several individual changes helped to reinforce the others, which made rapid changes to their wellbeing. We may have to rethink what we were taught as kids.
"Many of us know that we need to drink more water but yet it is estimated that up to 70 per cent of us are dehydrated at any one time."
Studies Linked to Soda Industry Mask Health Risks
November 19, 2016 09:54 AM
Can you trust the studies that are out there concerning soda and the health risks that it brings when consumed? Perhaps they're telling you the truth, but not the whole truth. Some are saying that the health risks of soda are being mAsked when the results are released to the public. What should you know?
"The notion that sugary drinks play a major role in the spread of obesity has prompted authorities and health officials to increasingly call for soda taxes and similar measures aimed at curbing their consumption."
five anti-aging food found in the grocery store
November 13, 2016 06:46 AM
The choices we make at meal time affect how we age. By choosing healthy options, some of the common symptoms of old age can be reversed, removed, or mAsked. Many vitamins and nutrients prevent diseases that are mostly diagnosed during old age and maintain a healthy body. Eating correctly is essential to preserving our youth.
"Tomatoes, eggplants, blueberries, blackberries, and other colorful fruits are packed with antioxidants. These help combat free radicals that damage healthy cells and suppress the immune system."
Benefits of Neroli Oil
February 27, 2014 11:48 AM
Neroli oil is an essential oil that has been used for aromatherapy for a long time. It is produced from the bitter orange tree known as citrus aurantium. Neroli oil is believed to be a source of a variety of health benefits ranging from physical to mental health. It has a sweet smelling aroma with a floral fragrance that contains an element of citrus.
Neroli oil has a variety of health benefits some of which are outlined below;
Neroli oil is widely used for aromatherapy. Due to the sweet smelling fragrance of Neroli, inhaling the aroma has an effect on the brain region responsible for emotions control. This brain region is referred to as the limbic system and has a direct connection to the nervous system. As a result, it has a direct effect on the heart rate, breathing, blood pressure and the immune function.
Several studies conducted in the past point to the fact that neroli oil can reduce anxiety levels on an individual. For instance, a research conducted in 2013 and later published in the Evidence-based Complimentary and Alternative Medicine found that the sweet fragrance in neroli oil when mixed with other sweet smelling essential oils including lavender and chamomile for use in aromatherapy treatment significantly alleviated anxiety and greatly improved the quality of sleep among patients in an ICU.
High blood pressure
According to a study conducted in 2012, neroli oil plays an important role in the control of high blood pressure. The study involved 83 people who suffered from prehypertension. The patients were Asked to inhale a range of essential oils including neroli, lavender, marjoram and ylang-ylang for a period of 24 hours. The results showed that the patients assigned to inhale neroli oil showed a significant decrease in the level of blood pressure as compared to other essential oils.
Other health benefits
Neroli oil can also be used to reduce headaches, colds, indigestion, and insomnia as well as boost the immune system.
Keeping your body alkalized
November 10, 2013 09:46 PM
About is Alkaline
Keeping Your Body Alkalized is a term used commonly to refer to maintaining acid-alkaline balance. With the right PH balance, your body will always be in good health. In order to enjoy optimum health, your body needs to have an equal amount of both acidic elements and basic (alkaline) elements.
What Are the Benefits of Alkaline?
There is the mostly Asked question- Can You Fight Disease by Keeping Your Body Alkalized? The answer is yes. Basically, PH has its main impact on the body enzymes. Enzymes can only function properly if the level of PH is right, otherwise, the body will be too weak to protect itself from diseases. In some worst scenarios, if the enzyme activity cannot take place anymore, a condition called acute acidosis, then one may be faced by a critical medical condition. If not handled immediately, the situation might lead to death.
Having excess of either can bring devastating impacts. For example, if your body has large volumes of acidity, then you might suffer from serious fatigue, arthritis or eczema. For you to eliminate such a condition, you need to consider one of the following diet tips or lifestyles to alleviate your overall health and maintain your body alkalized.
African Mango Fuit and Seed
December 12, 2012 10:49 AM
The African mango (Irvingia Gabonensis) also commonly known as the bush mango or wild mango is the fruit of the tree that is mainly found in Africa and South Asia. This tree belongs to the family of Irvingiaceae. These trees bear fruits that look like mango and hence the name. They contain nuts that are rich in fats and proteins. Besides being very tasty, African mango brings a lot of health benefits when consumed. The indigenous people of Africa used to eat the fresh fruits and nuts like all other nuts in bulk amounts. They were also ground and used to garnish the food. During early 1990s, this fruit had caught the attention of scientists from western countries. It is those people who have brought to light the wonderful medical powers of this fruit and discovered that the nuts of this fruit possess weight reducing properties.
This was however confirmed later with the help of some tests. In the first test, the subjects were given the fruit and were Asked to continue their lifestyle by not making any changes to the type and the amounts of the food they consume and by not changing their exercise habits. Miracle! The subjects have lost weight! This test stood as the conformity to the weight loss property of African mango. Besides reducing the weight of the people, African mango also has certain other health benefits. It suppresses hunger and also contributes to a drastic reduction in the levels of cholesterol. It can also well regulate the sugar levels of blood.
African mango is also good for the health of heart. Above all, it does not cause any adverse side effects even when consumed in large amounts. It is been consumed in large amounts by the people since times immemorial. This is considered to be the secret behind the slim build of many tribes living in Cameroon and Nigeria. Also the people of these tribes are very less prone to cardiovascular diseases. The African mango reduces the body weight via various processes. It boosts the body metabolism and helps in burning the stored fats. It regulates the levels of leptin, the hormone that lets the body know it is hungry. Hence this reduces the appetite naturally and allows people to eat little. It also delays the process of digestion.
Hence it makes the body to feel full and avoids all the unnecessary craving for food that makes people put on weight. Hence this will help in losing weight without putting any extra efforts for it. With the increasing popularity of African mango as weight-loss aid, many extracts or supplements of African mango are now available in the market. However, one has to make sure about such products before using and check if Irvingia Gabonensis is the main ingredient in it. In the end, it can be said that African mango is really a boon to all those suffering from excessive body weight or obesity. The fact that is adding up to their happiness is that it does not demand any exercise or diet control to reduce the weight.
What are the Health Benefits of Oligonol?
March 23, 2012 08:12 AM
Oligonol is one of the few existing products in the market that has helped so many people so when one is Asked what are the health benefits of Oligonol it's guaranteed that they won't fall short of words to say. This health supplement has anti-oxidant and anti-aging properties that help you achieve the best possible state of wellbeing. The following are some of the health benefits that you can get from using this natural supplement;
Improves blood circulation:Oligonol helps in improving blood circulation because it contains anti-oxidant elements that help in enhancing blood flow to the vital organs of the body.
Helps boost immunity: this health supplement fights against infectious bacteria and its agents and this is because it contains the lychee fruit which is a good source of vitamin C.
Helps reduce fatigue: in the research to find out what are the health benefits of Oligonol it was found that it helps speed up the body's recovery from fatigue after a period of physical exercises.
High energy levels: Helps increase energy levels in the body due to the fact that it helps facilitate the body's metabolic processes which in turn improves digestion.
Protects the body against cardiovascular diseases: when medical practitioners did a research on what are the health benefits of Oligonol, they found out that it contains minerals that include copper and potassium. These two minerals come from the lychee fruit. Potassium helps control a body's blood pressure and heart rate and for this reason protecting it from against diseases like strokes. On the other hand, Copper is important for the production of red blood cells in the human body. These blood cells are used to deliver oxygen to the body organs, tissues and muscles and without them the body would fail to function.
Reduces calorie levels and visceral fat production: use of oligonol health supplements helps reduce heart diseases risk that are brought about by visceral fat. Oligonol also contains elements that are rich in dietary fiber content and this helps control excess body weight.
Boosts memory: when Asked what are the health benefits of Oligonol persons who had previously used the health supplement said it helped them remember stuff more easily than they did before they started using it.
Reduces stress levels: use of oligonol has proven to reduce peoples stress levels and it has been used as a remedy for depression as an added point to the research on what are the health benefits of Oligonol.
Inhibits production of influenza virus: previous studies gave sufficient proof that oligonol inhibits the production of the influenza virus by blocking the attachment of the virus to the body cells.
Improves skin: oligonol helps improve the skin appearance by reducing wrinkles and helping get rid of freckles on people's faces.
In addition, the oligonol health supplement is safe. This is because it is made from pure natural ingredients, and has no negative interactions therefore it can be used by all who would like to find out what are the health benefits of Oligonol and in turn benefit from it.
What is Vitamin K Good For?
February 15, 2012 10:05 PM
Understanding Vitamin K
Vitamin K can be found in different forms, Phylloquinone is vitamin k1 and it is found in plants. Vitamin k2 is referred to as Mena Quinone and is produced by the intestinal bacteria. It can also be obtained from purified fish. The synthetic version of this mineral is called Menadione.
The role of the mineral is to aid in the blood clotting functions. When there is a deficiency, the production of prothrombin and various clotting factors is reduced. With time a person begins showing signs of hemorrhage.
The human body is incapable of synthesizing the mineral so you need to get it from dietary sources. The intestinal bacteria produce it as a metabolic by product. It is hard for someone to suffer from a deficiency since the vitamin is available from so many sources.
Vitamin K Stability
Since it is water soluble and heat stable there is no risk of leeching or inactivation during cooking. However, strong acids and alkalis have a destructive effect on the substance. Even though gamma irradiation is used to prolong the shelf life of food it inactivates the mineral.
Bile has to be present in order for the vitamin to be absorbed by the body. Lipoproteins in the bloodstream are responsible for transporting it to the liver. When it gets to the liver it is in is inactive form. A reductase is needed in order to revert it into its active state.
How Vitamin K Is Made
Normal intestinal bacteria are usually destroyed by prolonged use of antibiotics. This means that the body is unable to synthesize the mineral. The patient is put on supplements so as to prevent hemorrhagic tendencies. When a person is taking the supplements they are administered via intravenous or intramuscular injections. In some cases people are Asked to take the supplements orally.
During the first weeks of their lives babies can suffer from hemorrhagic conditions due to a deficiency in vitamin k. in order to prevent this from happening, the infants are routinely injected with natural minerals at the time of birth depending on their weight. Medical practitioners do not use the synthetic version because it is toxic to babies.
A person suffering from a deficiency of vitamin k has certain symptoms such as excessive bleeding, less active prothrombin in their blood, their blood takes long to clot and if they are newborns they suffer from hemorrhagic episodes. There are a number of medical conditions and treatments that can cause a deficiency.
If you have a medical condition that interferes with the absorption of fats in the intestines then you could suffer from a deficiency of vitamin k. some of the conditions that lead to the problem include obstructive jaundice, ulcerative colitis, gallbladder disorders and diarrhea. When you have any one of these conditions your body is unable to absorb the vitamin.
You can also suffer from a deficiency if you use mineral oil as laxatives. The vitamin usually attaches itself to the oil droplets in your intestines instead. The body is unable to absorb it so it is excreted in the feces. People are usually discouraged from using mineral oil to cure constipation because of this reason.
Fight Anxiety Disorders Naturally
December 14, 2010 04:27 PM
Do you suffer from an Anxiety Disorder?
Before considering how to test for anxiety disorders and discussing natural supplements that can help we should first discuss what anxiety disorders are - what the term means and if there are degrees of anxiety disorders as there are of depression and stress. First, what is anxiety?
Anxiety is a natural reaction to stress and it is anxiety that makes you worry about the consequences of not studying for an exam - so you study. It focuses you on problems so that you will be more likely to solve them, and helps you to perform better whatever you are doing. However, it can get out of hand and these positive mental processes become negative anxiety disorders.
With some people, anxiety becomes a dread of situations that were once everyday occurrences and can make your life a misery. Here are some forms of anxiety disorder.
Typical Anxiety Disorders
General Anxiety Disorder
Its symptoms include excessive sweating, worry, headaches, irritability, difficulty in sleeping, tiredness and tension in your muscles. It can lead to substance abuse and deep depression if left untreated.
These are three typical forms of anxiety, but how do you test for anxieties? Here are some tests that are used, beginning with the easiest - doing it yourself!
Testing for Anxiety Disorders
Many that believe they may have an anxiety disorder either tend to panic or go into a depression. It is far better to carry out a self-test. This anxiety test is very simple: simply tick which of the symptoms below you have experienced in the past six months:
I can't relax
I am always worried about something.
I get headaches for no apparent reason
I frequently sweat a lot and get hot flashes
I have no time for anybody and am easily annoyed
I find it hard to sleep and I often wake up during the night
My attention keeps wandering and I can't focus on anything
I sometimes get so worried I want to be sick or have a lump in my throat
If you have ticked more than three then perhaps you should pay your doctor a visit, or try some of the recommendations below.
b) Doctors' Tests
If you feel you might be suffering some form of anxiety disorder you should consult your doctor, particularly if you have tried the self test above and it indicates that you might be. Your doctor might carry out various tests for your general health, and if it is felt necessary you may be Asked about your family history: is there any history of mental problems in the family, particularly with your mother or father.
Other questions may appertain to your own physical and mental background, such as have you been stressed for any reason lately, have you suffered anxiety or panic attacks in the past and what is your normal use of prescription and non-prescription medications and drugs. Do you smoke, drink or take any social drugs.
It is important that you are totally honest: the doctor is not judging you, simply trying to find the cause of your problem. Under the terms of their oath they cannot divulge anything you tell them to anyone else, so be honest and let them help you. Among the tests you will be given will be to declare all your history of anxiety-related symptoms. To achieve that, you will be Asked a series of questions while the doctor assesses your mental condition.
Finally, you may be referred to a psychiatrist who will be able to help you more than your doctor. Psychiatrists have a good record in resolving anxiety disorders, but once you are diagnosed positively, what then? Chemical drugs? Or perhaps you would prefer something more natural such as herbal remedies.
Herbal Remedies for Anxiety
There are a number of herbs that can be used to treat anxiety disorders. Here are the more commonly used of these:
Passion flower contains the active substances maltol and ethylmaltol that your body's biochemistry uses to increase the concentration of GABA (gamma-butyric acid) in your brain. GABA is a neurotransmitter that calms you and helps you to relax and forget anything that is making you anxious. It relieves muscle tension, can lower your blood pressure and some equate its effect to that of Valium: although it is totally different chemically it is similar in its effect. It offers a sedative effect and helps you sleep.
Kava Kava root
Kava kava. Generally just referred to as kava, comes from the Pacific and the kavalactones it contains increase the concentration of neurotransmitters in your vascular system, particularly serotonin, the feel-good substance. Its sedative effects have been likened to that of alcohol, and it can certainly give you a lift and certainly helps you worry less as it reduces the negative symptoms of stress and depression.
St. John's Wort
St. John's wort is a well-known anti-depressant and it can also help reduce the symptom of anxiety. The hyperforin the plant contains helps to improve the brain's content of the neurotransmitters serotonin, dopamine and norepinephrine that make you feel good, and St. John's wort certainly washes away your anxiety. Not only that, but the napththodianthrone in another of its important components, hypericin, promotes a reduction in depression through the inhibition of monoamine oxidase, a pro-depressive enzyme.
An extract of valerian root can help you to relax and sleep well, and this can often be enough to prevent your anxiety attacks. A lot depends on their cause, but if the attacks are mild and don't require extensive medical or psychiatric intervention, then valerian can help, particularly in treating stress-related anxiety. Make sure you stick to the recommended dose because valerian can be dangerous if taken to excess.
The four herbal remedies above should between them be all you need to treat your anxiety. One major problem is that, just like any chemical drugs, they only treat the symptoms and not the underlying cause which is something you and your physician will have to work on yourselves.
However, until then, the above herbal remedies for anxiety disorders are generally safer to use than prescription drugs and each has a well proven effect, both on the symptoms of anxiety and on depression.
May 07, 2009 05:45 PM
L-carnitine is amino acid essential for the metabolism of fats into a form of energy necessary for extended aerobic activity. Originally discovered in Russia, and Germany a year later, the structural formulation of carnitine, as it is correctly known, was determined in 1927, although it is physiological and biochemical activity was not understood until the 1960s.
The amino acid is biosynthesized in the liver and kidneys from lysine and methionine. The vitamins niacin, B6, C and iron are essential for this reaction to take place. However, the supply of L-carnitine has to be supplemented by the diet, good sources being dairy products, red meat, nuts and seeds, pulses and fruits such as apricots, bananas and avocado. Most of the L-carnitine supply of the body is stored within the muscle tissue. However, it is not unusual for conditions to arise making it difficult for the body to obtain all the carnitine required.
L-carnitine enables fatty acids to be transported into the mitochondria, where cell metabolism occurs. The biochemistry is discussed below, although in simple terms the amino acid allows body fats, in the form of triglycerides, to be made more readily available for the generation of energy required for extended exertion. In this way, body fats can be used for energy and the supplies of glycogen stored by the liver can be retained for emergency use.
By providing the energy for endurance and stamina in this way, carnitine makes use of an otherwise unavailable energy source, and has the added benefit of reducing body fat stores and reducing strain on the heart.
Although there is generally a plentiful supply of L-carnitine available in a healthy diet, supplementation can ensure that a deficiency does not occur. Supplements are available in the form of L-carnitine or its acetylated derivative, acetyl L-carnitine.
In order for fatty acids to be used in the production of energy, their long-chain acetyl groups have to get inside the mitochondria where they are oxidized to the acetate to be used for the production of energy via the Citric Acid or Krebs cycle.
In order for the biochemistry to take place, fatty acids must be rendered suitable for binding to the carnitine molecule. The chemical grouping with a good affinity for L-carnitine is the acetyl or acetyl group, available in the molecule acetyl coenzyme A (CoA). The free fatty acid, therefore, is attached to coenzyme-A by means of a thioester bond, catalyzed by means of the enzyme fatty acetyl-CoA synthetase. The reaction is then completed by means of in organic pyrophosphatase.
In this way, the fatty acid in the form of an acetyL-carnitine derivative can be transported through the mitochondrial wall. This transportation takes place by means of several steps. These are:
1. As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I. This enzyme is conveniently located on the outer mitochondrial membrane.
2. The enzyme carnitine-acetylcarnitine translocase helps the acetyL-carnitine through the membrane.
3. Another enzyme, carnitine acetyltransferase II, located on the inner mitochondrial membrane, converts the acetyL-carnitine to acetyl-CoA, liberating the carnitine which returns to the muscle mass.
L-carnitine is the only known substance that allows fatty acids to cross the mitochondrial membrane, and therefore deficiencies must be avoided.
Another way in which carnitine is used in energy production is in the Krebs cycle itself. Part of this cycle involves the conversion of guanine diphosphate to the higher energy form guanine triphosphate. In this way energy can be stored in much the same way as it is in the conversion of ADP to ATP. Succinyl CoA is involved in this conversion, and one of the by-products of it is a corresponding succinate, that is then converted to a fumarate by the action of L-carnitine fumarate. Carnitine, therefore, has two parts to play in the production of long-term energy from the fatty acids contained in body fats.
Since the fatty acid triglycerides contained in body fats are a major source of energy in the heart and skeletal muscles, it is easy to understand how L-carnitine is believed to lead to the increased energy levels required for stamina and staying power. A major reason for its effect on longer-term or extended energy requirements is that in enabling stored body fats to be used for immediate and longer-term energy requirements, L-carnitine allows emergency glycogen stores to be retained for use once immediate fatty acid supplies or those of carnitine have been depleted, and so allows the energy supply to be extended even farther. Research has also suggested that the amino acid can possibly be used to treat liver and kidney disease, diabetes and chronic fatigue syndrome.
As with many supplements, the question is often Asked how does L-carnitine work in practice as opposed to the claims made for it by the supplement providers? Recent research indicates mixed results, but sufficient to justify its use. It is generally accepted that a supplement is necessary when there is a deficiency, but once that deficiency has been corrected further intake is unnecessary. However, it is also believed that during long and extended periods of exercise a carnitine deficiency does occur as L-carnitine is used up, and the supplement is necessary to ensure sufficient energy supply throughout the period of exercise.
There has also been a case reported in the Journal of Clinical Neurology (Negoro, Tsuda, Kato & Morimatsu, 1995) where a deficiency, caused by anorexia nervosa damaging the liver to the extent that it was unable to synthesize L-carnitine, was remedied by means of an oral supplement. Studies on endurance athletes have been mixed, ranging from no effect to L-carnitine being found to promote weight loss.
Carnitine has no unknown harmful side effects, and has been studied for medical applications other than as an energy supplement. For example it possesses extensive antioxidant properties, and can be used as a supplement against oxidative stress and the prevention of the lipid peroxidation that is a precursor to atherosclerosis.
Its use in osteoporosis and reducing bone mass is also being studied. The concentration of L-carnitine diminishes with age, and affects fatty acid metabolism in a number of tissues. Bones are particularly affected since they require continuous reconstruction. Without detailing the biochemistry involved in this, administration of carnitine helps to reduce the speed by which this occurs. Trials are so far been carried out only on animals.
In studies on both healthy volunteers and patients with type II diabetes, L-carnitine was found to improve storage of glucose in both groups, although its oxidation increased only in the group with diabetes. Other studies carried out include improving the function of neurotransmitters in the brains of elderly patients and in the treatment of Alzheimer's and Parkinson's disease, and other neurological disorders.
In conclusion then, although the jury is out on the use of L-carnitine is an energy-giving or weight-loss supplement, it appears to be effective where the body's stores of carnitine could be depleted such as with long-term exercise, natural deficiencies or deficiencies caused through age. It is also under study in the treatment of various medical conditions. On balance, it would appear that the prospective benefits of L-carnitine render it worthy of use.
Lutein 20mg (FloraGlo)
September 26, 2008 03:49 PM
Maintains Healthy Visual Function*
It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the first four weeks of the study, plasma levels increased five-fold from pre-supplement measures, and then remained at this level for the duration of the study. It was also shown that, due to increased deposition of lutein in optical tissues, macular pigment density increased by an average of 5.3% at the 4-week mark, and continued to increase until the duration of the study.1
A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids might play a protective role in supporting the maintenance of healthy vision.2
The Age-Related Eye Disease Study (AREDS) was a landmark study of the effects of diet and antioxidant supplementation on eye health. The study enrolled over 3500 subjects aged 55 to 80 years who were followed for approximately 6 years. Among the data collected in this multi-faceted study was a self-administered Food Frequency Questionnaire (FFQ). The AREDS Report No. 22 examined the data from the FFQs and determined that, of the nutrients evaluated, only lutein and zeaxanthin were directly related to maintaining eye health with statistical significance3. These findings corroborated similar results of an earlier multi-center study published in the Journal of the American Medical Association that also found that those with a higher intake of lutein and zeaxanthin maintained healthier eye function.4 These promising results have spurred the design of a second major clinical trial (AREDS2), which is currently enrolling participants to study the impact of supplemental xanthophylls (FloraGLO® Lutein and zeaxanthin) and other nutrients on age-related eye health.5
In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg FloraGLO® lutein, 10 mg FloraGLO® lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the FloraGLO® lutein and FloraGLO® lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.6 These results demonstrate FloraGLO® lutein’s beneficial effect on maintaining healthy visual function.
Newly published research has demonstrated that lutein and zeaxanthin supplementation may enhance visual performance under glare conditions. Forty healthy subjects took daily doses of 10 mg FloraGLO® Lutein plus 2 mg zeaxanthin for six months. They were evaluated for changes in macular pigment, glare disability and photostress recovery at the onset of the study, and at 1, 2, 4 and six months. After six months, subjects experienced an average increase in macular pigment optical density (MPOD) of 39% compared to baseline, and all but two participants experienced some increase in MPOD. This increase in MPOD was also directly related to measured improvements in visual performance after exposure to bright light, as well as photostress recovery.7 This study suggests another way in which lutein and zeaxanthin can help support optimal visual function in healthy individuals.
Potent Antioxidant Protection*
Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.8
More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol9 demonstrating its potential as a high-powered antioxidant.
A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental models of a number of body systems.10
Supports Healthy Skin*
A recent randomized, double blind, placebo-controlled study has demonstrated the positive effects of oral and topical administration of lutein on skin health parameters (surface lipids, hydration, photoprotective activity, skin elasticity and skin lipid peroxidation). Forty female subjects were divided into four treatment groups. Treatment options included oral administration of 5 mg of FloraGLO® Lutein twice daily or placebo and topical administration of 50 ppm FloraGLO® Lutein twice daily or placebo. Each treatment group received either an active oral treatment with a placebo topical treatment, a placebo oral treatment with an active topical treatment, both active treatments, or both placebo treatments. Statistically significant improvements were seen in all five parameters tested in all treatment groups compared to the group receiving only placebos. The greatest overall improvements were seen in the group receiving both active oral and topical treatments, while lesser but still significant improvement was seen in both the active oral only and the active topical only groups. Additionally, oral administration of lutein conferred superior photoprotective activity (as measured by skin surface redness after exposure to ultraviolet light) and prevention of lipid peroxidation (as indicated by levels of malondialdehyde in skin lipids after exposure to ultraviolet light) than either topical lutein or placebo.11
Diverse Cinical Benefits*
Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.12
Suggested Adult Use: One softgel daily with food, or as directed by a health care professional.
Does Not Contain: milk, egg, wheat, sugar, sweeteners, starch, salt, or preservatives.
1. Berendschot TT, et al. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Opthalmol Vis Sci. 2000 Oct; 41(11): 3322-6.
2. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7.
3. Age-Related Eye Disease Study Research Group. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep; 125(9): 1225-32.
4. Seddon JM, et al. Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration. JAMA. 1994 Nov; 272(18):1413-1420.
5. www.nei.nih.gov/neitrials/viewStudyWeb.aspx?id=120. Clinical Studies Database. Age-Related Eye Disease Study 2 (AREDS2). Last Updated 2/28/2008. Viewed 5/15/2008.
6. Richer S, et al. Double-mAsked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230.
7. Stringham JM and Hammond BR. Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008 Feb; 85(2):82-8.
8. “Lutein and Zeaxanthin”. PDR Health. www.gettingwell.com/drug_info/nmdrugprofiles/nutsupdrugs/lut_0164.shtml
9. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32.
10. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S.
11. Palombo P, et al. Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol. 2007; 20: 199-210.
12. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.
July 31, 2008 02:46 PM
Feverfew is most commonly used in the treatment and prevention of migraine headaches. Migraines are extremely common and can be very difficult to treat. Other methods of relieving pain have been explored because, for many migraine sufferers, conventional treatments have not been successful. Feverfew is one of the most successful forms of alternative treatments that have been found for treating migraines. Many studies have been conducted which have validated the already existing knowledge of many herbalists: feverfew is a great tool for helping to prevent migraines in many cases.
Although feverfew had long been used for treating headaches, its popularity declined with the advent of modern medicine. The herb has resurged into medical interest after the wife of a doctor who worked for the British National Coal Board had been suffering from migraines and was told by a coal miner to trey chewing on two feverfew leaves a day. After trying the herb, the woman noticed improvement, with fewer and less severe migraines. Her husband then urged a migraine specialist in London, Dr. E. Stewart Johnson, to test feverfew, with the results of several studies now showing it to be effective.
Dr. Johnson agreed to try the herb because he had many patients who had been suffering from migraine pain for years and had yet to find a successful treatment. Originally, he tried the herbal remedy on only ten of his patients. The results of this trial were so promising that it led to a study of another 270 of his patients, with seventy percent reporting that they received significant improvement when receiving feverfew for their headache pain.
Following this, a group of researchers in the City of London Migraine Clinic were led by Dr. Johnson to conduct a study, which was reported in the British Medical Journal, investigating seventeen patients who had already been using feverfew for at least three months. All were Asked to discontinue use of their original method of treating with feverfew. Eight patients were given a capsule of feverfew, while the other nine were given a placebo.
Those that were given a placebo had an increase in frequency and severity of headaches, nausea, and vomiting, while those that were given feverfew capsules had no increase in frequency or severity of their migraines. This research has led to the belief that feverfew is advantageous in the prevention of migraines. Many other studies have been done to further test the effects of feverfew. It has been concluded that feverfew treatment is effective and there were always definite improvements in the group that used feverfew. Additionally, there were no serious side-effects that appeared to exist.
Feverfew seems to have similar properties as NSAIDs such as aspirin and ibuprofen. Also, the parthenolide that is found in feverfew is the main inhibitor for the formation of compounds that promote inflammation. Parthenolide reduces the secretory activity of blood platelets and white blood cells. This is important because migraines are thought to be associated with abnormal platelet behavior, as they are responsible for the release of serotonin, which constricts blood vessels and leads to migraine pain.
Feverfew is now recognized by the British and Canadian governments as a migraine treatment and is often prescribed by doctors. Many physicians and pharmacists have recent began to take more interest in the use of herbal remedies, especially since patients are beginning to become more interested in natural methods of healing.
April 23, 2008 11:21 AM
Chromium is a trace element in your body, meaning that it is present only in very small quantities, yet like many trace elements it is extremely important to your health. Most people associate chromium with the shiny finish on car fenders, but it is more than that.
Chromium oxide was discovered as being a part of crocoite, better known as red lead, which is actually lead chromate, sometimes containing some molybdate and perhaps vanadium. Although it was discovered in the middle of the 18th century, it was not until 1797 that chemist Louis-Nicholas Vauquelin discovered it for what it was. He synthesized it in his laboratory in 1798, which is the ultimate proof of the identity and chemical structure of any substance.
It was eventually named chromium, after the Greek ‘chroma’ meaning color, because its compounds are highly colored, normally yellow, red and green, and it is chromium that gives emerald its green color. It is also found in low concentrations in the human body, but too low, thankfully, to color your body red, green or yellow! Perhaps Martians contain a lot of chromium!
The first indication of the potential benefits of chromium to health was when a pork kidney extract called the Glucose Tolerance Factor was discovered in 1957 to enable rats to improve their use of insulin in maintaining the effective use of blood sugar in generating energy. The GTF contained chromium, and that was believed to be the effective ingredient.
Diabetes is a condition in which people either do not generate enough insulin or cannot use it properly. Insulin is a hormone biosynthesized in a group of cells known as the islets of Langerhen in the pancreas and is a necessary part of your metabolism. Your metabolism converts carbohydrates and various sugars into glucose, and when the glucose level reaches a certain concentration in your blood, you stop feeling hungry and the pancreas is stimulated into secreting insulin.
The insulin allows the cells to admit sugar and the mitochondria within them to convert the glucose to energy. Your body likes the blood glucose level to be maintained at between 70 and 110 mg/dl. If it falls below 70, then you will be suffering from hypoglycemia, but you can be above 110 if you have recently eaten. If your blood glucose is being measured it must be at least four hours after your last meal, which is why you are Asked to fast first. The absolute maximum is 180 mg/dl, above which you are in trouble and suffering hyperglycemia.
If your pancreas cannot produce any insulin you are regarded as having Type 1 diabetes, and if it produces too little or your body cannot use it effectively, it is Type 2 diabetes. It is believed today that chromium is one of the factors involved in allowing the cells to absorb glucose, and that without it the mitochondria are unable to convert your blood glucose into energy.
Although up to 90% of Americans are thought to have a low chromium content, few are believed to be deficient and there is a big difference between the two. However, pregnant women and the elderly are particularly prone to a deficiency, as are those that consume too many sugary foods. A deficiency in chromium not only leads to an excess of blood sugar however, but also of cholesterol and triglycerides. This can in turn lead to atherosclerosis, heart disease and strokes.
Although the role of chromium in the control of blood sugar levels was discovered in the 1950s, it was not until the 1970s that it was proven. As with many such proofs it came about accidentally, through what was known as Total Parenteral Nutrition (TPN). This provided intravenous nourishment to patients who were unable to eat, and contained a mixture of the nutrients believed to be essential to life.
However, the mixture was based on current knowledge, and it was found that some patients developed the symptoms of hyperglycemia, or high blood sugar levels. This was what would have been expected of untreated diabetics, but none were diagnosed with the condition so the cause was a mystery. The physicians responsible for the treatment had no option but to administer insulin, even though there appeared to be no deficiency in the patients.
If you are with us so far, then you will realize that the insulin would not have had the expected result. That is because the condition is not caused by too much sugar or carbohydrate in the diet, and also not caused by a deficiency of insulin. However, due to the known role of chromium in the action of insulin, it was then thought that TNP solution would be improved by adding chromium. When chromium was added in small quantities of under 50 micrograms (5 hundredths of a gram) the patients’ condition improved to normal, and the effect of chromium on blood sugar levels was finally proven.
So how does chromium achieve this? In fact the biochemistry is complex, and dietary chromium works in a different way to the chromium picolinate that is the most popular form of chromium supplement. However, in a nutshell, what appears to happen is that its effect on human tissue may be through an increase in the activation of Akt Phosphorylation, which is a protein within the body cells that enables the easy absorption of glucose into the cells.
In addition to that, cell membranes contain insulin receptor sites that respond to biochemical signals from messengers such as hormones and nutrients, and it is believed that chromium might be involved in promoting the binding of insulin to these sites. Alternatively, it is possible that it may promote the reactions that occur after the insulin has bound to the receptor site, an occurrence that is referred to as a post-receptor event.
Whether chromium is involved in a post-receptor event or in binding the insulin top the receptor sites, there is no doubting the importance of the element to the overall insulin-glucose-energy metabolism, and that the trace element chromium is indeed important in helping your body cells to absorb glucose.
Msm Is Good For More Thank Just Joint Health
March 27, 2008 11:07 AM
When Asked to think of essential minerals, sulfur is probably not the first item that comes to your mind. But organic forms of this element shine brightly within every cell. No type of sulfur shines more brightly than methylsulfonylmethane, which is commonly known as MSM. MSM helps to form a vital connective tissue component and is best known as a joint supplement. However, skin is made of the same basic stuff, a strong protein called collagen, so it isn’t surprising that MSM also provides cosmetic benefits.
Collagen, which is a mesh of protein fibers that supports all the other skin cells, is what actually holds the skin together. These fibers are extremely flexible, yet very tough, with collagen actually having a greater tensile strength than steel. There are different varieties of collagen: type I through type XII. One of the main reasons that a child’s skin is so soft and smooth is that it is filled with type III collagen, which is the kind found in fast-growing tissue. As the child ages, this type is replaced with the tougher type I collagen. However, as the skin continues to age, the amount of collagen in the body begins to decline, causing wrinkles, discoloration, and other signs of skin aging.
The protein that is found within collagen is actually loaded with sulfur, which explains why MSM has been shown to restore a softer look to those people who use it. Users of MSM report that hair grows faster and thicker with the use of MSM and nails are also stronger. Some practitioners even found that scleroderma, which is a condition marked by thick, hard skin, actually is improved by the use of MSM.
Joints also contain collagen and MSM delivers sulfur to these tissues, which is what made it a great supplement in the first place. Among people ages 40 to 76 with arthritic knees, MSM improved the symptoms of pain and physical function. MSM is even more effective when taken in conjunction with other joint aids including glucosamine and chondroitin. One study showed that glucosamine and MSM reduced pain and swelling more quickly when they were taken together than when taken separately.
MSM also seems to help ease pain by directly stopping pain signals as they travel along the nerves. This ability has led to its use in treating conditions like back pain, carpal tunnel syndrome, fibromyalgia, and tendonitis. Along with younger looking skin, MSM users have reported another use: reductions in allergy miseries. Scientists have discovered that MSM seems to block histamine, which is the chemical that is responsible for allergic reactions, from reaching tissues such as the mucous membranes lining the nose.
Results from studies have been promising, as seasonal allergy sufferers report significant symptom relief and increased energy levels. For pain relief, fewer allergy attacks, and softer smoother skin, MSM is the best choice to provide your body with a healthy boost of sulfur. More information about MSM and its abilities can be found at your local health food store.
Apple Cider Vinegar to Fight Heart Burn
February 16, 2008 08:55 AM
Strange as it may seem, apple cider vinegar can be used to fight heart burn, even though that type of vinegar is composed of acetic acid the same as any other. It wouldn’t seem logical to use an acid to alleviate a condition caused by excess acidity in the stomach, but all will be clear shortly.
First, let’s have a look at what cider apple vinegar is, and what health benefits it can impart to the body. There is more to the old maxim regarding an apple a day than most appreciate. Although an orange has more vitamin C, apples have a lot going for them. They not only contain the soluble dietary fiber and prebiotic pectin, that can help reduce blood cholesterol levels, but are also rich in vitamins and minerals. Many consider apple cider vinegar the form of the apple that provides its ultimate health benefits.
Hippocrates himself has written of the health benefits of apple cider vinegar and used it for the benefits to health that it imparted. That goes back almost 2400 years, to an age when the biochemistry of the body was unheard of and even the alchemists had yet to work their magic. There was no surprise then that an acid could be used to increase the alkalinity of the body since the terms had yet to be understood, let alone invented.
The later applications of vinegar followed a path that would be expected of a substance recognized as a form of medicine, and it has been poured over wounds to sterilize them from early in history, and by people of the 14th and 17th centuries to protect themselves against the Black Death and the Great Plague respectively. It was believed by people in these times that the disease was transferred by breathing in the ‘ill vapors’ and that a vinegar-soaked cloth over the face would protect them.
Many people, associate vinegar with ‘bad wine’ or solutions of acetic acid, generally 5%. But how is real cider apple vinegar produced? All vinegar has acetic acid as its key ingredient. The reason that it can be produced from wine is that acetic acid is produced naturally by the fermentation of ethanol, or ethyl alcohol, the main alcoholic product of the fermentation of sugars. If the fermentation of wine is allowed to continue after the sugar has been used up, then the yeast will act on the ethanol and convert it to acetic acid. In fact the word comes from the old French ‘vin aigre’ or ‘sour wine’, due to it resulting from the undesirable continuing fermentation of wine.
The concentration varies according to the use it is put, though commercial pickling vinegars can be distilled to any required concentration of acetic acid. Apple cider vinegar is obtained by the over-fermentation of apple must usually used for cider, and can be obtained either the clear filtered form, or unfiltered with a hazy light brownish color. Although the manufactured distilled vinegars consist of acetic acid at various concentrations, natural vinegars contain by-products of the fermentation process such as citric and tartaric acids.
However, none of this explains why apple cider vinegar should help to cure heartburn. The first thing you should keep in mind is that this type of vinegar has some nutritional value that will be explained later, but also that it is less bitter than many other types of vinegar and many enjoy drinking it with a small amount of honey as an energy pick-me-up and also to prevent various digestive problems that it appears to alleviate such as bloating and diarrhoea.
The reason that many people experience heartburn is due to the body finding that that the acidity of the stomach is lower than it should be to digest a meal. There might be several reasons for the body believing this, such as drinking too much milk during the meal and thereby neutralizing some of the acid while also introducing more fat to be digested. The body reacts by injecting more acid into the stomach. Excessively spicy foods or alcohol can cause the same effect.
Stomach acid is concentrated hydrochloric acid that is very corrosive and can even dissolve a nail. If your stomach is slightly full, the acid causes a slight, but not full, reflux and you get the burning sensation known as heartburn due to the corrosive effects of the very strong acid on the esophagus, which is not protected by the stomach lining that is designed to withstand it. Sometimes the excessive acid in your stomach will cause the bottom of the esophagus to open, allowing some of the stomach contents into the esophagus giving the horrible burning sensation. That sensation is acid corrosion of your body tissue, but it is rapidly repaired and does no lasting damage unless it is chronic when you have to see your doctor.
Since heartburn is caused by excess acidity then, it will seem strange that you can use an acid to alleviate it. However, keep in mind that your heartburn is due to the body (brain) being convinced that there is insufficient acid in your stomach. If you introduce a weak acid, then you can convince your brain that the acid has been brought to a satisfactory level and so it will stop sending signals to the stomach lining cells that secrete the HCl.
If you remember what I Asked you to remember above, regarding the traditional uses of apple cider vinegar and how easy it is to drink, then that vinegar is the ideal acid to take. It floods the stomach with acetic acid and signals pass back and forth between the stomach wall to the brain and back again to the effect that the stomach has enough acid and so no more hydrochloric acid need be secreted.
Had you treated it with milk or even an antacid, it would have worked initially, but eventually the signal would be initiated and the lining would secrete more HCl. With an antacid that can occur after the stomach contents have been passed on, but although it has had its effect, your food will have been poorly digested, and so the better remedy is likely not an alkaline antacid but a weak acid such as apple cider vinegar.
That’s how it works, but what other benefits does it bring to you. For starters it is a good source of potassium which is essential to maintain a proper cardiac rhythm. Potassium can also help to maintain a good blood pressure, and it is necessary for healthy nails, hair and teeth, and also helps to repair damage to soft tissues and to allow cells to repair internal tissue loss.
Potassium is an essential mineral, although there is normally sufficient in a healthy diet. However, if somebody is displaying the symptoms of potassium deficiency then this form of vinegar can help to resolve the problem. The elderly especially can benefit from a regular dose.
Other than its antiseptic effect, the most common popular use of apple cider vinegar, however, is to fight heart burn and in that respect it is very effective, even if it seems a bit of a paradox.
Lutein - A plant pigment provides sun protection from the inside out.
July 09, 2007 01:21 PM
A plant pigment provides sun protection from the inside out.
Energy on earth begins with the sun’s rays, which spark the photosynthesis in plants that ultimately powers all life. (Petroleum is the residue of prehistoric plants crushed over eons into liquid form.) But the sun’s energy is not totally benign for us humans; excess exposure can cause skin to wrinkle and eyesight to dim.
Enter lutein. This plant chemical, reddish-orange like the setting sun, has become a hot commodity over the past several years because of its ability to protect both eyes and skin against sun damage. A member of the carotenoid family of nutrients, lutein is generally paired with its partner, Zeaxanthin, in a wide variety of foods, including egg yolks, fruits, corn and leafy greens such as spinach (where its bright color is mAsked by the green of chlorophyll). That’s a good thing, since your body can’t make lutein and so needs to obtain it from your diet.
The sun produces a whole spectrum of light rays, from the visible (red through violet) to the invisible or ultraviolet (UV). UV rays—both ultraviolet-A (UVA) and ultraviolet-B (UVB)—are troublemakers. They attack collagen, the protein that gives skin its shape, which leads to wrinkles and other signs of aging. What’s worse, UV is also capable of damaging skin cell DNA, a process that can promote cancer development. And UV isn’t the only culprit: The sun’s visible blue rays are believed to help create harmful molecules called free radicals within the skin.
The clue to lutein’s importance in fending off skin damage lies in the fact that it is found throughout both the outer (epidermis) and inner (dermis) skin layers, where as an antioxidant it fights free radicals and as an orange pigment it soaks up blue light. In one study, using lutein both orally and topically produced improvements in skin hydration and suppleness (Skin Pharmacology and Physiology 4/19/07). Lutein has also shown an ability to counter the inflammation and immune system suppression associated with excess UV exposure (Journal of Investigative Dermatology 2/04).
What is it? A red orange carotenoid found in a number of fruits and vegetables, generally with a similar compound called Zeaxanthin.
What does it do? This powerful antioxidant helps protect the eyes against both cataracts and age-related macular degeneration (AMD); it also appears to defend the skin against sun damage and has been associated with reduced arterial wall thickness, a measure of cardiovascular health.
The Eyes Have It
Your eyes, like your skin, are directly exposed to the sun’s UV rays. Such exposure can cloud the eye’s lens to create cataracts. It can also disrupt the retina at the back of the eye particularly the macula, the part of the retina responsible for clear central vision—which can result in age-related macular degeneration.
Not surprisingly, the eye is yet another one of the body’s lutein hot spots. This pigment is especially concentrated in the macula; in fact, of the 600 or so carotenoids that exist in nature, only lutein and Zeaxanthin are found within this all important structure. So it also isn’t surprising to learn that they Eye Disease Case Control Study, one of the first large-scale investigations into carotenoids and eye health, found a link between reduced AMD risk and high levels of lutein and Zeaxanthin. Current research has focused on the use of supplemental lutein in AMD patients, with promising results.
It isn’t only the outside of your body that may benefit from lutein. When oxidized by free radicals, LDL cholesterol settles into arterial walls. Lutein may help slow this process; in one study, people with the most lutein in their blood had 80% less vessel-wall thickening than those with the least (circulation 6/19/01).
So enjoy some fun in the sun. But respect the power of those golden rays, and let lutein help make playtime a safe time. –Lisa James.
Safe Solutions for Chronic Pain
March 30, 2007 12:09 PM
Safe Solutions for Chronic Pain
One of the biggest challenged in healthcare today is the problem of pain. There are simply too many people living each and every day with ongoing, unremitting chronic pain. And there are far too many healthcare providers who – for a variety of reasons – are failing to adequately address this serious problem.
Recently, 368 doctors who routinely care for patients with chronic pain agreed to take part in a unique study. The doctors were surveyed about the pain medicines hey prescribe, what kind of treatment goals they hope to achieve, and how they felt about their ability to help their patients. They were also presented with four chronic pain vignettes or mock case studies and Asked to select the best treatment for each scenario from multiple choice answers.
Sadly, many doctors chose the worst treatment options in the case studies. The medications they reported using in their practices did not reflect current pain treatment standards. They tended to set low treatment goals 0 instead of aiming for a least a 75% reduction of pain for their patients, they settled for 10% to 20% reductions. And many of the doctors admitted they lacked confidence in their ability to relieve their patients’ pain and suffering.
Adding to the challenge are the almost daily news announcements about dangerous side effects in certain pain medications. Synthetic prescription COX-2 inhibitors, once hailed as the safest of drugs, have been linked to heart attacks, strokes, blood clots, and intestinal bleeding. The over-the counter (OTC) drugs aspirin and ibuprofen kill over 16,000 people each year. And acetaminophen, the most widely used pain reducer in the
As a doctor specializing in chronic pain disorders, I know that optimal pain management can be a real challenge. However, I also know:
-You do not have to live in chronic pain.
-Your chronic pain, no matter what the cause, can be reduced, and usually
-Chronic pain can be relived both effectively and safely with powerful all-natural
Q. What is chronic pain?
A. Sudden, or acute, pain occurs when pain signals immediately fire in your nervous system alerting you to an injury, like a broken ankle, or an illness, such as appendicitis. Once the injury heals or the illness is cured, the transmission of pain signals stop.
Ongoing – or chronic pain – is much different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial injury, such as sprained back muscles, or an initial illness, such as a serious infection. There might be an ongoing cause of pain, such as arthritis, cancer, or fibromyalgia. Chronic pain also occurs without any past injury or evidence of body damage.
The most common kinds of chronic pain are headache, low back pain, cancer pain, arthritis pain, and neurogenic pain (pain resulting from damage to nerves or to the nervous system itself). While chronic pain differs in its origin and where it occurs, it is generally your body’s way of saying that something urgently needs attention, and will not o away unless its underlying causes are addressed.
These causes can usually be determined if you remember the acronym “SHIN”. This stands for Sleep, Hormonal deficiencies, Infections/Inflammation/Impingement, and Nutritional deficiencies. When these are treated, pain often resolves.
Q. Why is it so hard to effectively reduce chronic pain?
A. Unfortunately, many physicians’ entire education in pain management consists of “giving nonsteroidal anti-inflammatory drugs or NSAIDs (pronounced en-sayds), COX-2 inhibitors, or acetaminophen and considering narcotics if the patient has cancer.
Some NSAIDs, like aspirin and ibuprofen, are available over-the-counter, while others, like the synthetic COX-2 inhibitors are only available with a doctor’s prescription. These mediations are usually inadequate and often toxic when used for chronic pain. And they do not address the problem(s) that the pain is trying to alert you to.
Q. What exactly are COX-2 inhibitors?
A. COX-2 inhibitors do pretty much what their name implies – they inhibit a natural enzyme in our body called the clclooxygenase-2, or COX-2, enzyme. There are two COX enzymes – COX-1 and COX-2 and both complete several actions in our bodies. One very important action that both COX-1 and COX-2 enzymes share is the speeding up of our body’s production of prostaglandins. These hormone-like substances are made by the cells of the body and have several important functions.
Some of the most powerful prostaglandins cause inflammation, pain, and fever when we are sick or injured. Prostaglandins also protect the lining of the stomach from the damaging effects of acid. Other prostaglandins make sure our platelets (important blood cells) make blood clots when needed. Still others help our kidneys get rid of unwanted salt and water. And researchers have just recently recognized the importance of still another prostaglandin that protects our heart and blood vessels.
The NSAIDs reduce pain by reducing prostaglandin production by blocking or inhibiting the COX enzymes. In theory – less prostaglandins, less pain and welling seems reasonable. But if you really stop and think about it, it’s pretty easy to understand why this method of pain relief might result in significant consequences.
Pain and inflammation are often needed for healing. And just as needed is the protection of our stomach lining, blood clotting ability, assisting kidney function, and keeping our blood vessels healthy. And scientists are beginning to understand if you interfere with one natural response, you may be disrupting the body’s ability to prevent extremes and imbalances.
That’s why using aspirin and ibuprofen can result in stomach ulcers, kidney problems, and internal bleeding. And that’s why using synthetic COX-2 inhibitors can result in high blood pressure, blood clots, heart attacks, and strokes.
Q. Why are we just now learning about the dangers of COX-2 inhibitors and other NSAIDs?
A. That’s a good question!
Many people over the age of 65 have chronic pain conditions and are frequent users of OTC and prescription NSAIDs. This age group also experiences heart disease and Alzheimer’s disease in greater numbers. So, if a 70 year old woman who’s been using Celebrex for the past two years for arthritis in her knees suddenly has a heart attack one morning, it would not be entirely unexpected.
For the past five or six years, researchers have been studying the possibility that NSAIDs may prevent certain cancers, Alzheimer’s disease, and other health problems. The ongoing, close scrutiny of large group of people taking these medications by scientists who were conducting these studies has resulted in the discovery of these dangers.
Q. What kind of natural compounds relieve chronic pain?
A. There are many – glucosamine, Omega-3 fatty acids, the B vitamins – the list goes on and on. Instead of disrupting normal bodily responses, these natural compounds work in harmony with our body to eliminate chronic pain. Three very powerful and very effective all natural plant compound pain and inflammation relievers are Sweet Cherry, Boswellia serrata, and White Willow Bark.
For many years there have been anecdotal or personal reports that claimed eating Sweet Cherries, specifically Prunus avium, wipes out back pain, arthritis, and gout. While anecdotal reports generally don’t account for much in the world of science, he sheer numbers of testimonials proclaiming the Sweet Cherry’s amazing ability to reduce pain made researchers sit up and take notice.
When Sweet Cherries were examined in the lab, it was easy for scientists to understand how this natural fruit is able to relieve pain. It seems Sweet Cherry’s bright red color is the key. Like many deeply colored fruits, Sweet Cherries are full of flavonoids called anthocyanins and proanthocyanidins.
These powerful plant compounds scavenge and destroy altered oxygen compounds called free radicals. Many degenerative, chronic diseases have been associated with the tissue damage caused by free radicals, including arthritis, heart disease, peripheral artery disease, and cancer. Cherry fruit extract is a natural anti-inflammatory compound, making it an excellent treatment for arthritis, fibromyalgia, and other chronic pain and inflammation diseases.
A pain relieving plant compound that comes from the bark of a tree, Boswellia serrata has been used by Indian healers for hundreds of years to reduce painful inflammation. When 20th century researchers looked at extracts of Boswellia Gum Resin in the laboratory they discovered the presence of powerful plant compounds, called boswellic acids.
Researchers found Boswellic Acids reduce inflammation in several ways. They open constricted blood vessels, improving blood flow to joints. They balance levels of leukotrienes – specific chemicals in the body that cause inflammation. And Boswellic Acids block two inflammatory chemicals that increase in asthma and inflammation of the colon. In addition to being helpful in treating these 2 illnesses, Boswellia has also been clinically studied and found to be quite effective in osteoarthritis and rheumatoid arthritis without any evidence of ulcers or stomach irritation.
Another bark extract, White Willow Bark is one of the oldest and most effective pain relievers. For over 2,000 years extracts from the bark of the White Willow tree have been used to ease aches and pains and reduce fevers. It is the original source of aspirin, but when used as the entire plant medicine, White Willow Bark is much safer than aspirin and quite effective.
White Willow Bark’s active ingredient is salicin and the combination of other compounds in the bark significantly enhances its pain killing power. In two large clinical trials of patients with chronic low back pain. White Willow Bark was found to be not only safer and much more effective than standard prescription therapies, it was also 40 percent more cost effective.
Salicylic acid from White Willow Bark lowers the body’s levels of prostaglandins, easing both acute and chronic pain. White Willow Bark reduces the pain and swelling of arthritis, headache, back and neck pain, muscle aches, and menstrual cramps. But, unlike aspirin, it doesn’t cause stomach bleeding or other known adverse effects.
Q. Do Sweet Cherry, Boswellic Acids, and White
A. They do indeed. Because they reduce both pain and inflammation by a broad combination of actions, these natural extracts have been proven to be excellent against arthritis, back pain, and pain from inflammatory intestinal diseases (Crohn’s disease and ulcerative colitis), and would be expected to be helpful in most kinds of pain.
Sweet Cherry, Boswellic Acids, and White Willow Bark relieve inflammation without causing stomach irritation, stomach ulcers, high blood pressure, blood clots, heart attacks, or strokes. That’s because these natural pain killers don’t disrupt the balance of enzymes or interfere with the body’s ability to prevent extremes and imbalances.
However, as with any pain therapy, Sweet Cherry, Boswellic Acids, and White Willow Bark work best when they are used as part of a comprehensive treatment plan to relieve the most common underlying causes of chronic pain or SHIN.
In addition, although these excellent natural remedies can often offer quick pain relief, natural remedies for severe chronic pains work best when they are given at maximum allowed doses and given 6 weeks to show their full effectiveness in combination with treating the pain’s underlying causes. The best chronic pain relief results when doctors and patients work together to meet the goals of treatment.
Some important last notes: Many causes of chronic pain are serious and life threatening. Everyone who is living with chronic pain must consult their doctor or other healthcare practitioner to determine the reason for their ongoing discomfort. In other words – make sure you know why you are having chronic pain and what’s causing the pain you want to relieve.
There are some types of chronic pain that only respond to opioids, or narcotic pain relievers. Morphine sulfate is an excellent pain medication and is used to relieve surgical pain, the pain of heart attacks, and pain from serious injuries. Morphine is also the very best drug for chronic cancer pain and non-malignant chronic pain. While many people fear opioids, these powerful pain killers can dramatically improve quality of life. If you are suffering with chronic cancer pain and you are hesitant to use morphine or another opioid, I urge you to discuss your concerns with your doctor other healthcare provider. No one with cancer should live with untreated or under-treated pain.
Even chronic pain can often be eliminated when SHIN is in combination with powerfully effective natural pain relievers. But, because some people may need to take pain relievers the rest of their lives, the medications they use must be safe as well as effective. The very safest come from natural plant compounds that have been studied for their ability to relieve chronic pain. You can become pain free and Sweet Cherries, Boswellic Acids, and White Willow Bark can help.
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.
Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.
To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.
Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.
Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.
Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.
In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."
In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:
• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.
• 78.9% of subjects showed an increased mean value of hair diameter.
• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."
Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.
Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:
• Total Number of Hairs: Significantly Increased
• Total Number of Terminal Hairs: Significantly Greater
• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher
• Hair Follicle Activation: Intensive
In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.
Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.
Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.
Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.
Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.
Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.
Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.
If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.
The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.
After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next Asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.
Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.
MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.
Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.
The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.
According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.
The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.
Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.
Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.
L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.
Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.
In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.
Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.
Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.
After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.
This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Q. Is Revita safe ?
A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.
Q: Can I have my hair colored or permed while using Revita ?
A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.
Q: What is SLS/SLES free ?
A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.
Q: Can I blow dry my hair after using Revita ?
A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.
Q: Who is a candidate for Revita ?
A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.
Q: What type of results should I expect with Revita ?
A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.
Q. Does Revita have any systemic side effects ?
A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.
Q. Does Revita work for women?
A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.
Q. I am using other topical treatments. Can I use Revita at the same time ?
A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.
Q. Do I need to use Revita for a long time ?
A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.
Q: Is stress a factor in hair loss?
A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
Q. If IP-6 comes from bran, wouldn’t eating more whole grain or high fiber foods = IP-6
November 22, 2006 01:42 PM
A. Scientists who study a specific IP-6 and inositol blend Asked this very same question and went to the laboratory to find the answer. They took cancerous tumors and exposed them to either the nutrients of fiber and bran, or to IP-6. The nutrients of the fiver and bran were the equivalent of a 20% bran diet. The scientists discovered that the IP-6 was twice as effective as the nutrients of the 20% bran diet.
In bran or fiber, IP-6 is bound to protein. For IP-6 to be well absorbed in the stomach, enter the bloodstream, and travel to the various organs where cancer has occurred, the IP-6 must first be separated from the protein. This normally happens with digestion, but it can take awhile and is inefficient. Phytase, an enzyme found in food and also the intestine, can actually break down IP-6, making it ineffective as a cancer fighter. The longer it takes IP-6 to be released from food, the more time phytase has to break down IP-6 to an ineffective form. Pure IP-6 is better, because it will be absorbed into the bloodstream before phytase has a chance to destroy it.
Testamonial by Wendy: Subject: DiGeorge Syndrome
September 19, 2006 05:50 PM
I was touched this morning by the attached E-mail. When someone tells me “these products are so expensive” these are the kind of stories that always come to mind. It is not about cost: IT IS ALL ABOUT VALUE. What else in this world has this kind of impact on health?
Subject: DiGeorge Syndrome
My name is Wendy and I live in Ponca City OK. This story is about my daughter Sydney and her journey with DiGeorge Syndrome.
DiGeorge syndrome is a rare congenital (i.e. present at birth) anomaly with symptoms vary greatly between individuals but commonly include a history of recurrent infection, heart defects, and characteristic facial features.
We learned about DiGeorge when Sydney was born. What a tough way to come into the world. Sydney had open heart surgery at 13 days old. We were told after her surgery that Sydney was born without a thymus gland. This gland is the home for the immune system. We were then told that she would likely die by the age of three. She would be very ill all of her life and would die from some type of infection. This devastated us!
One of the first people to provide some hope that there was something out there that could help was a friend of mine. His name is Tim O’Conner and told me about a company that provides glyconutrients. He is our pharmacist (we go to church together too). I had to call him from the hostpital with a medication list to make sure he had everything available in Ponca City before we could leave the hospital in Oklahoma City. Once we got to the pharmacy, Tim told me about the products and how it helps the immune system.
I had to think about it, research it and pray about it. I wasn’t just going to take his word for it! When Sydney was about 9 weeks old, I started her on glyconutrients, ¼ teaspoon twice a day. Because when Sydney was six weeks old, the immunologist told us she had a very poor immune system and to keep her away from everyone we can. No animals, no strangers, no church. So I really thought even more about the products. We started the products and went back to the immunologist at 6 months and at that point he told us that her immune system was probably better than mine! Then we Asked what else do we need to do and he said “let me hold her for a minute because I am not going to see her ever again”. I started to cry! I was so happy because I had been told so many terrible things about kids with DiGeorge Syndrome and how they are always sick and that pneumonia normally kills them. We have been so blessed! Until Sydney was 1 year old she had to take a form of calcium, I cant remember the specific type. We were told by the endocrinologist that she would always have a calcium deficiency. Guess what, she is off the calcium too! Genetics Asked what we had been doing with her, special therapy? No, just Sonner Start (a state funded occupational therapy) oh, and glyconutrients.
Every time we told a doctor about glyconutrients, they wanted to know more. We have told every doctor about this product. We have been told by all the genetic, immunologist, endocrinologist ect., that she doesn’t need to be followed by them any longer. Between that and prayer, Sydney is now almost 3 years old and is very healthy! Actually now, all we giver her are the glyconutrients kids supplements anywhere from 5 – 7 a day. She is great and loves the kids BEARS supplements!
Testamonial by Wayne. On March 25, 2006
September 19, 2006 05:49 PM
My name is Wayne. On March 25, 2006, I was working in may shop when a 3-foot crowbar fell from a 10 foot step ladder on top of my head. It didn’t knock me out, which was good because no one was home but me. I had a black and blue spot there for a couple weeks.
Two days later, on a Saturday, I started seeing double. My left eye wouldn’t follow to the left, so I was cross-eyed. My wife, who edits this newsletter, called our Glyconutrition doctor. He Asked if I’d had an MRI? So first thing Monday morning she calls the family doctor who cant see me until Thursday. They said to go ahead to the emergency room and get that done. The attending physician said it could have been a surge of high blood pressure or high sugar. The MRI showed no damage.
We then went to the eye doctor. He said I had 20/20 in both eyes. He crossed his fingers and said he thought it would come back, but It would take a long time. Two other doctors said it would come back in maybe 6 months.
My wife put me on the amounts of Glyconutrients the Doctor recommended. I’ve been a skeptic, but did as I was told. For a month I wore a patch on my eye or on my glasses and it wasn’t fun. I went back to see the eye doctor and Asked if he could put a prism on my lens to help the vision. My brother-in-law suggested that since he had the same problem several years ago. That really made a difference.
You should have heard my wife the day she saw that eye beginning to move in about 7 weeks! It kept improving and the first time I looked to the left and it didn’t bother me was july 25, 2006.
There’s a good reason to have a hard head, and God got my attention.
An Interview with Congressman Sam Farr, Representing California’s Central Coast.
May 30, 2006 02:36 PM
Ambassador to Health Profile
An Interview with Congressman Sam Farr, Representing California’s Central Coast.
Congressman Sam Farr, a fifth-generation Californian, represents the state’s beautiful central coast. His district encompasses the length of the big Sur coastline in Monterey County, the Monterey Bay National Marine Sanctuary, the Salinas Valley “Salad bowl,” the redwoods, mountains and beaches of Santa Cruz County, and the majestic rural landscape of San Benito County. The health and wealth of this region has been strengthened by Rep. Farr’s focus on the environment, education and the economy. Rep. Farr was raised in Carmel, California and graduated from Willamette University with a BS in biology. He later attended the Monterey Institute of International Studies and the University of Santa Clara. He is fluent in Spanish. As a tough advocate for the health food industry, he has lobbied for strict federal organic standards.
Todd: Congressman Farr, thank you for taking the time to speak with us! Id also like to thank you for all the great things you’ve done for our community, form funding marine sanctuaries and authoring the Ocean’s Act to expanding Pinnacles national Monument. The League of Conservation Voters and others have recognized you as an “Environmental Hero”. And, you’ve worked hard to support the economic vitality of central coast’s $3 billion agriculture industry which includes a substantial organic segment. Our backyard here is also the home of a robust group of nutritional supplement manufacturers. An estimated 187 million Americans are currently taking dietary supplements as part of their daily healthy diet. In California, we’ve got 792 natural product manufacturers and distributors. Where do you stand on the state of our industry?
Congressman Farr: Well, thank you for the introduction and for asking to talk to me about nutritional supplement issues. I am very supportive of this industry and include myself in the 187 million Americans taking dietary supplements. I think supplements offer many safe and viable tools to maintain your health. The continued growth of this industry is an indication of both consumer confidence in the products and the products’ ability to fill the gaps where conventional medical care falls short.
Todd: It is estimated that by 2030, more than 70 million Americans will be over the age of 65 and the cost of health care could reach $16 Trillion per year. A recent study by the Lewin Group showed that by taking certain dietary supplements, seniors can lead healthier, more productive, independent lives while saving billions in reduced hospitalizations and physician services. Do you share our view that a Wellness Revolution is needed to counter the dilemma of an aging population versus shrinking health care support in the future?
Congressman Farr: Our health care system is definitely facing a challenge, especially as the Baby Boomers hit their 60’s and Americans are living longer than ever before. As a Baby Boomer myself, I am well aware of America’s aging population and the impact that will likely have not only on our social institutions but also our fiscal well-being. I agree that dietary supplements do play and will play an even larger role in the future as more seniors look for a way to augment their diets in order to stay healthy and active longer than past generations.
Todd: Our industry is regulated by DSHEA (the Dietary Supplement Health and Education Act), which was passed unanimously by Congress in 1994 to create a reasonable regulatory framework for access to, information about, dietary supplements. But many say that the FDA and DSHEA weren’t adequately funded to do the job as tAsked. “Supplements are unregulated” is a false argument we sometimes hear. To ensure that the FDA is able to carry out the law as Congress intended, Representatives Dan Burton (R-Ind.) and Frank Pallone (D-N.J.) introduced H.R. 2485, the DSHEA Full Implementation and Enforcement Act of 2005. Did you support this bill and where does it stand today?
Congressman Farr: I think the DSHEA is a critical law and was proud to support it when Congress considered it in 1993 and 1994. I would certainly support H.R. 2485 if it came up for a vote in Congress. Unfortunately this bill has not moved since it was first introduced and referred to the Subcommittee on health in the house energy and commerce committee. Since this is an election year we have a tight schedule with only about 60 legislative days scheduled before we adjourn. That means it’s likely Congress will only finalize bills such as the appropriation bills that fund government before adjournment.
Todd: Our business climate has included some valid and rigorous challenges to improve our industry, from good manufacturing practices (GMP), to allergy labeling, to implications of Prop-65 in California. It’s disconcerting that a new bill, H.R. 3156 The Dietary Supplement Access and Awareness Act would try to capitalize on misconceptions about the industry. In an era of declining health care and declining insurance coverage, this bill would regulate supplements as prescription drugs. Among other things, it would also require adverse event reports to be turned over to the FDA, even though other foods, including those with identical ingredients, do not have the same requirements. This has the potential to be the next Prop-65-like Lawsuit mill. The result of H.R. 3156 would be chilling. It will knock smaller producers out of the market. It will result in higher prices for all supplements. It will decrease the availability of health-giving supplements to the public. What’s your feeling on this?
Congressman Farr: I am similarly concerned about H.R. 3156 and would oppose it if it came up for a vote in Congress. Like H.R. 2485, this legislation has been referred to a subcommittee on Health in the House Energy and Commerce Committee without any further action. The supplement industry has worked in good faith with the FDA since passage of DSHEA and H.R. 3156 would re-invent a wheel that isn’t needed. Instead, adequate funding as proposed in H.R. 2485 would provide ample oversight for the industry.
Todd: According to a recent study, 72% of the general population believe the government should fund more research on health benefits of nutritional supplements. Do you agreen and what can be done to meet this need?
Congressman Farr: I definitely agree that the federal government should play a bigger role in support of research regarding the health benefits of nutritional supplements. As a member of the House Appropriation Committee, I sit on the subcommittee that has jurisdiction over the FDA’s budget and I know the tight fiscal restraints the agency is under. I’ve worked with my colleagues to provide adequate funding, but it’s an uphill battle especially when we’re in a “robbing Peter to pay Paul” kind of situation. I recommend that people within the industry organize and use your consumer base to actively lobby Congress for additional funds. I’m fond of reminding people that the squeaky wheel gets grease – so let every Congress member and Senator know how much this issue matters to you.
Todd: When there is overwhelming scientific evidence that nutritional supplements provides relief for a disease condition, it currently takes a lawsuit to get the FDA to relent and allow the claim. Even then, the FDA strictly limits the claim and requires a disclaimer that does more harm than good in communicating this important information to the public. There is a new bill, H.R. 4282, The Health Freedom Protection Act that would end FDA and FTC censorship of health information. As an example, the 50% of all adult males who suffer from an enlarged prostate could receive relief from that condition by consuming a simple and safe ingredient, saw palmetto derived from the fruit of the dwarf American palm tree. The FDA censors that information. The public deserves a better opportunity to be informed about omega-3 EFA and heart disease, folic acid and birth defects, phosphatidylserine and cognitive impairment. Do you agree and do you support this bill?
Congressman Farr: I agree the public needs to access to the best information possible so they can make well informed choices about their health. I likely would support H.R. 4282 if it came up for a vote in Congress. Unfortunately this bill is in a similar situation as other we’ve mentioned in this interview – and again because of the tight schedule of an election year, it’s unlikely action will happen this year.
Todd: According to the barometer study, 85% of the US population is currently using some type of dietary supplement. Do you? Looking at your busy schedule from co-chairing the House Oceans Caucus to your seat on the Travel and Tourism Caucus, you are one busy congressman! Are you popping nutritional supplements please tell us!
Congressman Farr: I do take some nutritional supplements, though they vary and since Ginkgo Biloba isn’t among them I cant remember their names off-hand! One product I do use faithfully is Airborne to help me combat germs and colds that I might get from sitting on an airplane. But, like many Americans my life is over-scheduled and combined with the amount of air-travel I do, I find nutritional supplements helpful as I try to stay healthy despite my hectic lifestyle.
Todd: Thank you Congressman Farr! Live long and prosper!
DSEA Release of Health/Cost Impact Study Conducted by the Lewin Group, Initial Results, Wash DC; Nov. 2, 2005
NNFA database. Adam.F on 3-15-06.
DSEA Nutritional Supplement Barometer Study, 2005 Report, Prepared by the Natural Marketing Institute (NMI).
Todd Williams; Source Naturals Marketing Programs Manager.
Lutein to fight age-related macular degeneration!
February 27, 2006 05:53 PM
Lutein: The Antiordinary Antioxidant
Lutein belongs to a class of compounds known as carotenoids. Carotenoids in general are yellow, orange, or red pigments responsible for many of the colors of the foods we consume each day. To date, over 600 carotenoids have been identified in nature, but are only produced by plants, algae and bacteria leaving humans and animals to consume carotenoids in the diet. Forty to fifty carotenoids are consumed in the typical US diet, but only 14 have been detected in the blood, indicating a selective use of specific carotenoids by the body. Lutein is one of these carotenoids found in the blood and has been increasingly associated with eye health over the last decade.
Lutein’s role in eye health
In the human eye, lutein is concentrated in the center of the retina in an area known as the macula. Lutein is deposited in the macula through the lutein we consume in out diet or through supplements. This area is responsible for human central vision and is colored intensely yellow due to high concentrations of lutein. Lutein is thought to be beneficial for eye health by reducing damage in the eye in two ways: 1) by absorbing blue light (blue light is thought to increase free radical formation in the eye) and 2) by acting as an antioxidant, reducing damage in the eye caused by free radicals. Leading carotenoid researchers believe these functions may lead to a reduced risk of age-related macular degeneration (AMD) and cataracts.
Age-related macular degeneration
Macular degeneration is the leading cause of blindness in the USA in those over 65. twenty-five and thirty million people are afflicted worldwide and currently there are no effective treatments for the disease. The disease has two forms known as dry and wet AMD.
Ninety percent of AMD cases diagnosed are the dry form. In dry AMD, also referred to as early AMD, debris deposits under the center of the retina (known as the macula) interfering with its normal function. Parts of the macula atrophy, causing the central vision to slowly become dimmer or more blurry. Wet age-related macular degeneration, also known as late AMD, often develops in areas where dry AMD exists. Abnormal blood vessels grow and leak blood and fluid under the macula, causing scarring, which leads to rapid loss of central vision.
Dr. Joanna Seddon published one of the first studies demonstrating a link between lutein intake and AMD risk in 1994 (1). This epidemiological study compared the risk of developing AMD to nutrient intake and showed a significant reduction in risk for developing AMD as lutein intake reached 6mg per day (57% reduction in risk). Since the Seddon study, researchers have shown that increasing dietary lutein intake raises blood levels of lutein as well as levels of lutein in the eye (2). Bone et al. demonstrated that eyes with higher levels of lutein were less likely to be afflicted with AMD (3).
The latest clinical trial that investigated lutein’s role in AMD is known as the lutein antioxidant supplementation trial (L.A.S.T) (4). This study evaluated the effects of lutein supplementation for one year in 90 veterans diagnosed with dry AMD. Supplementation with lutein in these subjects significantly increased the concentration of lutein in the macula. Improvements in visual function were also detected with lutein supplementation. Glare recovery, visual acuity, and contrast sensitivity were all improved. This study continues to build on clinical evidence that the dry form of AMD may be responsive to changes in nutrition.
A cataract is a natural clouding of the lens, the area of the eye responsible for focusing light and producing clear, sharp images. For most people, cataracts are a natural result of aging. Currently in the US, cataracts are the second leading cause of blindness in the elderly behind AMD.
Lutein is the major carotenoid that has been identified in the human lens asn is thought to provide similar benefits to the leans that are seen in the retina. Two large epidemiological studies consisting of >70,000 women (age 45-71) and >30,000 men (age 45-75) compared the risk of cataract extraction to nutrient intake (5,6). Similar to AMD, a significant reduction in risk of cataract extraction was associated with lutein intakes of 6mg per day (20% reduction in risk). Besides cataract extraction, higher levels of lutein consumption have been associated with a decreased risk of cataract development and improvements in visual acuity and glare sensitivity in people with age-related cataracts.
The richest source of free lutein in the typical US diet are dark green leafy vegetables, with the highest concentration found in kale followed by spinach.
The average daily lutein intake is low, average between 1-2 mg/day. Currently there is no recommendations of the dietary guidelines for Americans 2005 (9 servings of fruits and vegetables every day) you would consume between 4 and 8 mg of lutein a day (7). Epidemiological evidence, animal models, and clinical data have indicated levels of 6-10 mg a day may be necessary to realize the health benefits associated with lutein consumption. By continuing to increase our intake of lutein, we begin to ensure the optimal health of our eyes.
Seddon et al. (1994) dietary carotenoids, vitamin a, c, and e, and advanced age-related macular degeneration. Eye disease case-control study group. JAMA. 272: 1413-20.
Bone et al. (2000) Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp. Eye Res. 71: 239-45.
Bone et al. (2001) Macular pigment in donor eyes with and without AMD: a case-control study. Invest. Ophthalmal. Vis Sci. 42: 235-40.
Richer et al. (2004) Double-mAsked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-relaged macular degeneration: the veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 75: 216-30.
Brown et al. (1999) A prospective study of carotenoid intake and risk of cataract extraction in the US men. Am. J. Clin. Nutr. 70: 517-24.
Chasen-Taber et al. (1999) A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am. J. Clin. Nutr. 70: 509-16
HHS/USDA. Dietary Guidelines for Americans 2005. //www.healthierus.Gov/dietaryguidelines/CDC. National health and nutrition examination survey data 2001-2002. //www.cdc.gov/nchs/about/major/nhanes/nhanes01-02.html
Brandon lewis, Ph.D. is the applied research and Technical services manager at kemin health, L.C. in des moines, iowa. His responsibilities include the initiation and management of laboratory projects pertaining to the inclusion and analysis of kemin ingredients in vitamins and dietary supplements, as well as developing new applications and prototypes that include kemin ingredients. Prior to joining kemin, Brandon was enrolled at the university of Florida where he received his Ph.D. in Nutritional Science from the department of Food Science and Human Nutrition.
Olive Leaf Extract
January 02, 2006 10:17 AM
In today’s stressful world, immune system health is more important than ever. History has proven that no matter what we do to combat viruses, bacteria and parasites, they have the remarkable capability to mutate for survival, often returning in a more virulent form than before. New strains of the flu and other microbial invaders are being discovered at an alarming rate, and modern medicine is constantly on the defensive. At the time this was written, the Centers for Disease Control (CDC) in Atlanta is predicting a “bad flu season” because a “killer drift variant” strain of flu had been discovered, called type A Fujian. This new strain has already caused deaths abroad, and vaccinations are strongly recommended, especially for the very young and the elderly.
However, mutating microbes are only part of the problem confronting our immune systems. Factors such as environmental pollution and over-processing of foods are believed by many researchers to play a major role in many health conditions. Which means, more than ever before, you need to make sure your immune system is functioning at peak efficiency. Fortunately, there are a number of natural products available that can assist you in reaching this goal.
One of the most effective discovered to date is Olive Leaf Extract (OLE). Natural olive leaf extract is derived from the olive tree (Olea europaea), which happens to have a very long and interesting history. One of the most revered botanicals, the olive tree is mentioned numerous times in the Bible. One of the earliest and most powerful mentions is the delivery of the olive branch to Noah by a dove, a sign that the floodwaters were receding and life was returning. The olive tree was, and still is, a life-giver. It’s fruit is used for food, and the oil is used for cooking and as a source of light to ward off the darkness. Ancient cultures soon discovered that the various components of the olive tree provided a myriad of health benefits as well, benefits confirmed by modern science.
Extract of olive leaves is one of the best, if not THE best, natural antimicrobials and antioxidants ever discovered.* Oddly enough it might have been well recognized in this role much sooner since it was reported in the mid-1850’s that a bitter tea brewed from olive leaves might be a potential cure for malaria. However, not all great discoveries are immediately recognized as valuable, and physicians of that era didn’t give much credence to the reports. It wasn’t until decades later that a simple analysis conducted on olive leaves led to the discovery of an active component, the phenolic compound oleuropein, which has since been associated with many health benefits.
More recently, numerous studies have been conducted on olive leaves and the active components found in the leaves, with a preponderance of positive results. A 1999 study conducted at the University of Rome assessed the antimicrobial activity of oleuropein and hydroxytyrosol, two of the most active components in olive leaf extract. They were pitted against many different bacterial strains, including salmonella and staphylococcus, in vitro. The study concluded, “Olea europaea can be considered a potential source of promising antimicrobial agents” for the support of intestinal and respiratory health.* 4
A 2002 study conducted at the University of South Australia compared the effectiveness of some of the typical components of the Mediterranean diet, including oleuropein and hydroxytyrosol, as reactive oxygen species inhibitors and free radical scavengers. Researchers also examined their capability in protecting against low-density lipoprotein oxidation in vitro. Results clearly indicated that these components are potent inhibitors of free radical generation, as well as effective free radical scavengers.* 5
NOW® Foods carries a number of olive leaf extract products, including our Olive Leaf Extract 500mg, standardized to contain 6% oleuropein, our Extra Strength product with 18% oleuropein and 100mg of Echinacea Extract, and Olive Leaf Glycerite liquid, which contains 18% oleuropein.
Why would you want a standardized Olive Leaf Extract product over a whole herb Olive Leaf product? We’re glad you Asked! Standardization allows for consistently effective herbal products because the active ingredient, or marker compound, is accurately identified and measured, ensuring that the product delivers a certain minimum level of the active component or components. In simpler terms, standardized herbal products allow the consumer to obtain the benefits of an herb without having to consume massive quantities because there is a much greater concentration of active components, which also improves the effectiveness of the herbal product. Purchasing standardized Olive Leaf with a guaranteed concentration of oleuropein is a smart choice.
Bird Flu Vaccine in short supply !!
November 26, 2005 02:23 PM
U.S Unprepared for Bird Flu Pandemic
Vaccine in short supply.
Officials worldwide are preparing for the worst, as bird flu spreads through asia and into Europe, resulting in the death of 140million chickens and ducks. Meanwhile waterfowl travel their migratory paths, shedding virus contaminated feathers, droppings and saliva into the water, air and soil.
Human cases of avian flue have so far been limited to individuals who had direct contact with sick birds. Experts, however, believe the virus could mutate into a form easily transmitted from human to human. The current strain, known as H5N1, is particularly lethal; it has killed 61 people—half of those infected.
A few times each century, flu pandemics sweep the world. One of the worst, the 1918 flu, killed 50 million people; it was also a bird flu, which jumped directly to humans. The grimmest forecast today is a pandemic that could kill millions. And, among developed nations, the united states is one of the least prepared.
After Delay, U.S. Must Wait in Line.
Congress and the President are considering spending billions to buy the drub tamiflu, which has been shown to reduce the duration and severity of bird flu. A few months ago, the manufacturer could have delivered much of this supply; now, orders placed by other countries have exhausted production capacity for the next two years, according to the New York Times. U.S. health agencies have 2 million doses on hand, enough to treat 1% of the population.
A Military Response?
Anticipating a crisis, President Bush Asked Congress to consider using the military to enforce a quarantine, and requested a review of the Posse Comitatus Act of 1878, which prohibits the armed forces from engaging in domestic policing. Critics question the effectiveness of a military response to a health problem, and point out that authorities can already call in the National Guard to deal with civil disorders.
Contagious Disease and the Wellness Revolution.
Concentrations of poverty, especially in Asia; huge, crowded farms and factories; poor hygiene; insufficient public health facilities; companies that refuse to produce unprofitable vaccines—all must be addressed to prevent future pandemics.
Meanwhile, individuals must do all they can to protect themselves. Wash your hands often and keep them away from your eyes and nose. Avoid contact with people who have respiratory illnesses. Clean surfaces used to prepare raw poultry with hot, soapy water, and cook poultry thoroughly. With so many potential assaults on your health, a wise strategy that is at the very core of the wellness revolution is to strengthen your immune system. Get enough sleep, take good daily multiple, and visit your health food store for a wide range of immune-boosting herbs and special nutrients to help you stay well this winter.
Sources: After Delay, U.S. Faces Line of Flu Drug, New York Times, 10/7/05; U.S. Warns of Future Flu Pandemic, Associated press, 10/10/05; Review of the monster at our door: the global threat of avian flue by Mike Davis.
Bird Flu Facts:
Symptoms: fever, cough, sore throat, aches, pneumonia.
Virulence of current strain: kills 100% of birds, 50% of humans.
Projected U.S. Pandemic Death toll: ½ million.
If Ip-6 comes from bran, wouldn’t eating more whole grain or high fiber foods provide IP6
November 11, 2005 06:30 PM
Q. If Ip-6 comes from bran, wouldn’t eating more whole grain or high fiber foods provide IP-6?
A. Scientists who study a specific IP-5 and inositol blend Asked this very same question and went to the laboratory to find the answer. They took cancerous tumors and exposed them to either the nutrients of fiber and bran, or to IP-6. The nutrients of fiber and bran were the equivalent of 20% bran diet. The scientists discovered that the IP-6 was twice as effective as the nutrients of the 20% bran diet.
In bran or fiber, IP-6 is bound to protein. For IP-6 to be well absorbed in the stomach, enter the bloodstream, and travel to the various organs where cancer has occurred, the Ip-6 must first be separated from the protein. This normally happens with digestion, but it can take awhile and is inefficient. Phytase, an enzyme found in food and also the intestine, can actually break down IP-6, making it ineffective as a caner fighter. The longer it takes IP-6 to be released from food, the more time phytase has to break down IP-6 to an ineffective form. Pure IP-6 is better, because it will be absorbed into the bloodstream before phytase has a chance to destroy it.
Prostate – Frequently Asked Questions…
October 25, 2005 09:57 AM
What’s a PSA test?
PSA stands for Prostate-Specific Antigen, a protein made by the prostate gland. It’s a simple blood sample that measures the level of the protein. In general, a PSA under 4 ng/ml (Nanograms per milliliter) is considered low, 4 to 10 is moderately elevated, and over 10 is considered high. Keep in mind, though, that prostate cancer isn’t the only thing or even the most likely thing that can cause PSA levels to rise. An enlarged prostate can also boost scores. Its important to have a digital rectal exam along with the PSA.
What’s a digital rectal exam like?
According to Tom Sansone, M.D. urologist at Bryn Mawr Hospital, says, “For a really vigorous exam, go to a urologist. Family practitioners tend to be more gentle and superficial.” An urologist will manipulate the gland for a full minute, exerting pressure in order to feel for nodules, areas of hardness, changes of consistency and symmetry. A normal prostate should have two symmetrical lobes and the consistency of a rubber ball. If it’s so hard that the doctor can’t indent it with this thumb, then he knows there’s a problem.
Can I still have sex with an enlarged prostate?
Yes, in fact, the more sex the better! Regular sex, or at least ejaculation, is beneficial since it gets the juices flowing and clears our the ducts.
If I have an enlarged prostate will I develop prostate cancer?
Not necessarily. According to Ronald L. Hoffman, M.D., medical director of the hoffman center in NYC and host of the “Health Talk”, a syndicated radio program, “It is very common to have prostate enlargement without cancer. In fact, prostate enlargement is virtually universal among north American men, while prostate cancer is not. Nevertheless, its estimated that the vast majority of men may have ‘microfoci’ of cancer: tiny clusters of cancer cells that are normally of very little consequence because they are slow growing. But some of them can develop down the line.” (Conscious Choice, June 1999)
Strontium Bone Maker 60 VC - Strengthen Bones
July 27, 2005 12:06 PM
Helps maintain strong, healthy bones.*
In Vitro and Animal Studies
Strontium is a bone-seeking mineral incorporated by ionic substitution for calcium onto the crystal surface of bone.2 In the test-tube (in vitro), strontium inhibits the activity of osteoclasts, bone cells that break down bone, or “resorb” bone as part of the normal bone remodeling process.3 The effect of strontium, in the form of strontium ranelate (a salt of strontium and ranelic acid), was studied in monkeys over a six-month period. Strontium altered the remodeling of bone in the monkeys, resulting in decreased bone resorption with a concomitant maintenance of bone formation. A trend toward increased volume of osteoid, the organic matrix of bone, was observed, although this was not associated with defects in bone mineralization.4 In another animal study, monkeys fed strontium at high doses for six weeks showed a marked increase in bone strontium content. No harmful effects on bone mineral chemistry or structure occurred.5 At low doses, strontium has been shown to increase the number of bone forming sites in thighbones of adult rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.6 Strontium was shown to reverse bone loss induced by estrogen deficiency in rats.7
Human clinical trials have examined the effect of strontium on bone in postmenopausal women. In the dose-ranging (Phase 2) PREVOS trial, women in early menopause were administered strontium ranelate or a placebo for two years. Strontium ranelate was given at daily doses of 125 mg, 500 mg or 1 gram. (Total weight of compound; strontium plus ranelic acid). Compared to women in the placebo group, who lost bone, women on strontium at the 1 gram dose showed statistically significant increases in bone mineral density (BMD) of the hip, thigh and lumbar spine. Biochemical markers of bone formation, such as serum alkaline phosphatase, increased. No effect on markers of bone resorption was observed, leading to the conclusion that strontium ranelate, at the 1 gram daily dose, increased bone formation without decreasing bone resorption proportionally. It was concluded that 1 gram per day is the minimum effective daily dose of strontium ranelate in these women.8
In another Phase 2 trial (STRATOS trial), 353 postmenopausal women with osteoporosis, who had experienced at least one spinal fracture, took strontium ranelate for two years at daily doses of 500 mg, 1 gram or 2 grams. Women on the 2-gram dose showed a significantly greater increase in lumbar spine BMD than those on placebo. The number of subjects who had new spinal deformities was significantly reduced.9 As in the PREVOS trial, serum levels of alkaline phosphatase, a marker of bone formation, increased, while markers of bone resorption (breakdown) decreased. The overall conclusion is that the minimum effective daily dose of strontium ranelate (whole compound) is 1 gram in early postmenopausal non-osteoporotic women and 2 grams in postmenopausal women with osteoporosis.10
Phase 3 efficacy studies on strontium ranelate have been conducted on 1649 subjects in 12 countries. These studies began with an open-run (non-controlled study period in which subjects took calcium and vitamin D supplements to normalize their blood levels of these nutrients.11 Following this, two parallel groups were administered 2 grams daily of strontium ranelate or placebo for 3-years. The subjects continued to take calcium and vitamin D during the study. In subjects on strontium ranelate, BMD increased in the lumbar vertebrae by 14.4 percent and in the thighbone by 8.3 percent. The number and risk of vertebral fractures decreased.12
Suggested Use: Take two capsules daily. Calcium intake must also be adequate. Do not take this product with calcium supplements.
Strontium ranelate was well-tolerated in the trials discussed above. The incidence of adverse events in subjects on strontium ranelate was statistically equivalent to the placebo groups, and no negative effects on hematology and other biochemical parameters have been observed.
In view of the fact that subjects on the strontium trials also took calcium, and in some cases vitamin D, to maintain normal blood levels of these nutrients, it is important to ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.13 In rats with chronic kidney failure, strontium has been shown to cause osteomalacia, a condition in which bone is softened due to lack of mineral content. For this reason, people on kidney dialysis should not use strontium supplements.14
1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 1952; 13:59 -66.
2. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone 2001;28(4):446-53.
3. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 2002; 450:11-17.
4. Buehler J, Chappuis P, Saffar JL, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis) Bone 2001;29(2):176-79.
5. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996 Sep;11(9):1302-11.
6. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18(3):253-9.
7. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 1993;8(5):607-15.
8. Reginster JY, Deroisy R, Dougados M, et al. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-mAsked, dose ranging, placebo-controlled PREVOS trial. Osteoporosis Int 2002; 13:925-31.
9. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis––a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87(5):2060-66.
10. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporosis Int 2003; 14(Suppl 3):S56-S65.
11. Meunier PJ, Reginster JY. Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis. Osteoporosis Int 2003;14(Suppl 3):S66-76.
12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350(5):459-68. 13. Grynpas MD, Marie PJ. Effects of strontium on bone quality and quantity in rats. Bone 1990;11:313-19.
14. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes osteomalacia in chronic renal failure in rats. Kidney Int 1998;54:448-56.
Best Lutein Featuring Biolut Marigold Ext., 60 VC
July 27, 2005 11:54 AM
It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the course of the study, plasma levels increased five-fold from pre-supplement measures. It was also shown that macular pigment density increased by an average of 5.3% after 4 weeks due to increased deposition of lutein in optical tissues.1
A second study compared the oral bioavailability of esterified lutein, the form in Best Lutein, versus non-esterified lutein in 18 human volunteers. Serum levels of lutein were measured at particular timepoints after consumption of a single dose of lutein. Researchers found that in these individuals, the lutein ester formulation was nearly 62% more bioavailable than non-esterified lutein, as determined by a higher mean area under the curve (AUC) and higher serum concentrations.2
A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids may play a protective role in supporting the maintenance of healthy vision.3
In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg lutein, 10 mg lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the lutein and lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.4 These results demonstrate lutein’s beneficial effect on maintaining healthy visual function.
• Potent Antioxidant Protection*
Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.5
More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol6, demonstrating its potential as a high-powered antioxidant.
A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental models of a number of body systems.7
• Diverse clinical benefits*
Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.8 Safety
Suggested Adult Use: One capsule daily, or as directed by a health care professional. Take with or without food.
2. Bowen PE, et al. Esterification does not impair lutein bioavailability in humans. J Nutr. 2002 December; 132: 3668-3673.
3. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7.
4. Richer S, et al. Double-mAsked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230.
5. "Lutein and Zeaxanthin". PDR Health.
6. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32.
7. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S.
8. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.
Progesterone: Ignorance Is Not Bliss
July 25, 2005 09:42 PM
Progesterone: Ignorance Is Not Bliss
Has anyone ever Asked you if you might be suffering from a progesterone deficiency? Women ranging in age from 12 to 100 may be subject to low progesterone levels and as a result, can suffer from a whole host of mysterious ills related to a hormonal imbalance. While most women are fairly informed about birth control pills and estrogen replacement therapy with all of its controversy, few of us understand the very profound role progesterone plays in determining our overall health. Moreover, the therapeutic effects of natural progesterone remain relatively unknown and untapped. Of even more significance is that a growing number of women seem to be suffering from progesterone depletion and estrogen dominance. If you’re like I was, this notion struck me as a completely new concept. I can say now, in retrospect, that this bit of knowledge is clearly one of the most important pieces of information I have had the opportunity to research. So many symptoms that women have to endure are readily branded as just part of inevitable PMS or worse yet, products of an overactive imagination or emerging psychosis. It is has been through my own personal experience with terrible mood swings, horrendous periods and all sorts of miserable hormonal demons that I have come to write this booklet. Make no mistake however, the information contained herein is based on scientific fact and is backed by the experience of medical doctors. More than any other physician or scientist, Dr. John R. Lee, M.D. has pioneered and documented his remarkable results using natural progesterone from wild yam for his female patients. To say the very least, his findings have profound health implications for all women.
Natural plant-based progesterone may well be the most important breakthrough therapy for women to come out of the latter twentieth century. Ironically, its use from botanical sources has a long tried and true history. Like so many valuable natural treatments, the value of plant-based progesterones have been virtually ignored by modern medical practices.
Unfortunately, most physicians focus on the use of synthetic estrogen or artificial progestins to manage female disorders such as osteoporosis when, in reality, progesterone may be the key hormone. Ironically, natural progesterone, unlike its pharmaceutical counterparts, offers an impressive array of therapeutic actions with complete safety and efficacy. As previously mentioned, mainstream medicine continues to overlook the use of natural phytoestrogens which can offer practical treatment of hormonally-related disorders without negative side effects.
These simple plant-based medicinals have been used for generations by women of almost every culture and for good reason. These botanicals have been able to support the special health needs of both pre-and post-menopausal women with little or no side effects. Progesterone plays a profoundly more critical role in the maintenance of female health than previously assumed. Too little of this vital female hormone can lead to all kinds of menstrual disorders, infertility, miscarriages, osteoporosis and even cancer. Progesterone deficiencies are much more common that most of us would assume, even in younger women. Replenishing progesterone in its natural form is a safe and effective way of relieving a whole host of female symptoms ranging from the mildly annoying to the seriously debilitating. Simply stated: there are viable alternatives to popping synthetic hormones for problems like PMS or menopausal distress. In many cases, specific plant-based hormone creams can achieve better results without the significant health risks associated with synthetic hormonal analogues.
Today, the use of natural progesterone is dramatically growing as women and health practitioners alike become disillusioned with synthetic hormonal therapies. Using pharmaceutical estrogen has proven to be rather disappointing in treating osteoporosis.1 In addition, the controversy over the safety of birth control pills and estrogen replacement therapy for post-menopause rages on. In the midst of much misinformation concerning artificial hormonal drugs, plants like wild yam are being reconsidered and reevaluated for their intrinsic value.
Ironically, modern technological manipulations of these natural phytochemicals has resulted in more potency and more risk to the human body which was not designed to cope with artificial compounds. It turns out that ancient civilizations who turned to botanicals for female ills understood the value of natural therapies. In the face of high-tech pharmaceutical imitations, it turns out that Mother Nature knew what she was doing after all.
THE ORIGINS OF PYCNOGENOL
July 13, 2005 09:48 AM
THE ORIGINS OF PYCNOGENOL
For generations, certain tribes of North American Indians used bioflavonoids extracted from the bark of pine trees for a variety of disorders. Because of its marvelous healing properties, they called this pine the Annedda, or “tree of life.”
PINE BARK: GIVER OF LIFE
These native Americans, who routinely ate deer as their primary source of nutrition, when confronted with a scarcity of meat Asked themselves ... where does the deer get its strength? They discovered that deer stripped away pine tree bark and we re able to derive life-giving nutrients from its organic composition. It was also observed that devastating diseases such as scurvy did not afflict those who ate the bark, leaves or needles of this pine tree.
CARTIER’S ENCOUNTER WITH ANNEDDA TEA
In 1535, Jacques Cartier learned of the medicinal value of the bark, which remained relatively unknown until 20 or 30 years ago, when scientists reviewed his notes and commenced research. Cartier became caught in the bitter snows of Quebec, while attempting to navigate the St. Lawrence River. Cartier and his crew subsisted on hard biscuits and cured meat and eventually came down with what was believed to be scurvy. Scurvy is an abhorrent disease which causes a very slow and agonizing death. Several of Cartier’s men died before they were approached by the Quebec Indians who prepared a tea they called “Annedda” from the bark of a certain native pine tree. The men took the tea and used its leaves as poultices. Their recovery was almost immediate. What must have seemed like a miraculous substance was technically, nothing more than vitamin C with bioflavonoids naturally inherent to the pine tree.
MASQUELIER’S SUBSEQUENT DISCOVERY OF PYCNOGENOL
Cartier was resourceful enough to document the incident. Over 400 years later, a French professor, Jacques Masquelier, assigned to the University of Quebec discove red Cartier’s account. Because he was already involved in bioflavonoid research, he became greatly intrigued by pine tree extract. Dr. Masquelier isolated a bio-active substance known as proanthocyanidin.
THE EMERGENCE OF PROANTHOCYANIDIN
After returning to France, Professor Masquelier found that this compound could be extracted from the bark of the French Maritime Pine pinus maritima found in abundance in southern France. Intensive research by Dr. Masquelier led to the discovery of Pycnogenol, which is another name for the group of bioflavonoids known as the proanthocyanidins. Subsequent in-depth testing revealed that these compounds are a nutrient treasure far more valuable that anyone originally thought. In time, the grape seed was found to contain the same compound and today, is considered an excellent source of Pycnogenol in France.
HAWAIIAN NONI (Morinda citrifolia)
July 11, 2005 08:50 PM
In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:
Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni.
The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions.
Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic.
Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.
discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer.
ROOT AND ROOT BARK
Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells.
Body Systems Targeted
The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties.
Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended.
Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit .
NONI: ITS USE AND HISTORY
Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent .
Wonder Herb of Island Folk Healers
Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking.
Noni’s Medical Reputation
Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine.
A Timely Reemer gence
Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals.
TRADITIONAL USES OF NONI
Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15
decoctions to stimulate delayed menst ruation.
XERONINE: THE SECRET OF NONI?
One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit .
Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18
How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production.
MODERN APPLICATIONS OF NONI
Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure.
Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and Asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis.
xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion.
A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21
In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells.
with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration.
The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus.
The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions.
The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available.
While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes.
A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29
Skin Healing Agent
One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine.
burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30
The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions.
Complementary Agents of Noni
PrimaryApplications of Noni
June 25, 2005 07:23 PM
According to natives of the Amazon, when Tupan, the most powerful of all the Gods, decided to create man and woman and an environment in which they could t hrive, he assembled the other gods and goddesses and sought t heir assist ance. Jaci, the goddess of the moon, offered her help to Tupan. “I will teach the people how to grow seeds for food.
While many beneficial plants are steeped in myth and legend, few are as widely known and consumed among the natives of the Amazon river basin as catuaba, Erthyroxylum catuaba.
Revered as an enhancer of both libido and sexual potency, catuaba is a tree which grows widely across the northern Amazon.This most famous of all reputed aphrodisiac Amazonian plants is the subject of numerous indigenous songs,and the harvesting of catuaba bark (the part used for sexual enhancement) has become big business throughout Brazil.
In January of this year, I and two others went on a mission to the Brazilian Amazon to investigate catuaba as it is harvested and used by the indigenous people of that region. We possessed complementary skills.
My work involves researching and photographing indigenous native uses of plants around the world.My wife Shahannah, whose previous career as a marine mammal researcher put her on the ocean for three years, was our videographer.The third member, Bernie Peixoto, was born and raised in that region, speaks ten native languages fluently, and also holds a Ph.D in anthropology.We were a small, but capable group.
Entering Brazil through Manaus, we made contact with Antonio Matas,the most famous herbalist in that area.Antonio described to us numerous instances in which the use of catuaba had resulted in renewed sexual potency in men, and revived or enhanced libido in both men and women.Antonio also introduced us to a man named Sivao,the primary dealer of catuaba in the entire sprawling Manaus region. From Sivao we learned that catuaba was increasing in popularity every month, and had become one of the most sought after and widely used beneficial plants in northern Brazil, due to its ef fectiveness.
After our meetings in Manaus,we headed down the Amazon river where we stayed with Ipixuna and Crinicoru Indians in floating houses right on the river itself.
With the guidance of an outdoorsman named Geronimo and a fisherman named Jose’,we hiked into the forest,saw catuaba trees growing, and witnessed the harvesting and sale of the bark.In addition,we were led to two elderly women shamans,who described to us the sex-enhancing and restorative virtues of catuaba.
While space doesn’t permit an explanation of all that we saw and learned, we discovered during the course of our travels that while catuaba is used by almost all middle-aged men,it is also popular among couples of all ages for its enhancement of libido. More often than not,catuaba is used with muira puama. We Asked repeatedly why this was so,and each time we were told that the combination of the two plants results in significantly greater sexual enhancement than can be obtained by using either herb by itself. Most of the people with whom we spoke use catuaba personally, and they expressed great enthusiasm for catuaba’s sex-enhancing properties. Throughout history, people have sought to enhance their libido and improve sexual potency. Catuaba,a common tree growing widely across the Amazon river basin,has centuries of safe,effective use as a sex-enhancer.As more people become aware of the botanical treasures of the rainforest,catuaba is destined to become popular and widely used in this culture as well. The views expressed in this article are those of the author only, and have not been approved or endorsed by Nutraceutical Corporation or any of its subsidaries or affiliates.
Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplement
June 21, 2005 05:10 PM
By Adina Licht, MS
Adina Licht, M.S. is a Nutritional Scientist and Science Writer who works as a Marketing Specialist for Source Naturals. She has a B.A. in Environmental Science from UC Berkeley, an M.S. in Nutrition and Food Science from San Jose State University, and training in Technical Communication from Cal State Hayward. Her work has appeared in publications such as Advances in Packaging and Development, Health Supplement Retailer and Delicious Living.
Americans Need More Nutrients
The U. S. population is drastically malnourished. According to the latest A. C. Nielsen survey, only 12% of Americans claim to eat the 5 recommended servings of fruits and vegetables each day (Warner, 2004). And approximately 1/3 of the calories that people do consume are from nutrient-poor foods such as alcohol and soda (Yang, 2004). This combination has led to a population that consumes too few nutrients, which according to an article in the Journal of the American Medical Association (Fletcher, 2002) puts people at risk for long-term health concerns. With Americans eating fewer healthy foods, taking a daily multiple is one way for people to increase their intake of nutrients. But the search for what defines a good multiple can be confusing, even to health care professionals.
The Confusing U.S. Government Standards
Scientists first recognized the need for vitamins in the early 1900s (Levenstein, 1993). But setting U. S. government standards for vitamins and minerals didn't start until healthy soldiers were needed to fight World War II. And when a committee of scientists was Asked to determine the levels of nutrients needed to maintain good health they could only agree on "recommended allowances" to prevent deficiency with a wide margin of safety. In 1941, these allowances became the first Recommended Dietary Allowances (RDAs) for the nation (Levenstein, 1993). In 1997, the Food and Drug Administration (FDA) used latest RDAs to set the new Dietary Reference Intake (DRI) standards, which included Adequate Intakes (AIs) for when there was insufficient evidence to determine an RDA, and Upper Intake Levels (ULs) as the safe daily upper limit. To simplify the information, food labels express nutrient information as a percentage of the Daily Value (DV), which includes RDA values for a healthy adult who consumes 2000 calories per day (Whitney, 2002). However, these values do not include AIs or ULs and many individuals need different levels of nutrients than these.
Confusing Standards equals Confusing Recommendations
The RDAs and subsequent DRIs are the basis of the nutrient standards for at least 40 different nations and many professional health organizations. Currently, the American Dietetic Association (ADA) recommends that people who cannot reach the DRIs through diet take a multiple with nutrient levels that do not exceed the RDAs (JADA, 2001). And in 2002, the American Medical Association (AMA) published a paper that included a recommendation for all adults to take RDA levels of vitamin supplements in their Journal of the American Medical Association (Fletcher, 2002). Despite the benefits of having guidelines, most people only hear about the RDAs and DVs, which may be too low for preventing deficiencies while the ULs and AIs, which can be much more beneficial are rarely discussed. For example, the Daily Value of Vitamin E to prevent deficiency is 30 IU while the daily Upper Intake Limit is 1,467 IU. But, according to the ADA, as many as 75% of cardiologists recommend vitamin E to their patients to promote heart health, usually at a dosage of 400 IU (ADA, 2001; Meydani, 2004; & Whitney, 1998). And the Daily Value for Vitamin C is 60 mg while the daily Upper Intake Limit is 2000 mg, but in clinical studies it took 500 mg per day to help maintain healthy blood pressure (Whitney, 1998, & Hendler, 2001).
Lyle MacWilliam is a biochemist and former health advisor to the Canadian Ministry of Health, who decided to research, analyze and publish the Comparative Guide to Nutritional Supplements. In this book, the individually published recommendations from seven nutrition experts (Phyllis Balch, CNC, Dr. Michael Colgan, Ph.D., Dr. Earl Mindell, Ph.D., Dr. Michael Murray, N.D., Dr. Richard Passwater, Ph.D., Dr. Ray Strand, M.D., and Dr. Julian Whitaker, M.D.) were combined to create an ultimate blended standard of recommended median intakes for 39 nutrients to promote health. Those nutrients include vitamins, minerals, phytonutrients, and other supplements, that span 14 different health categories and are much closer to the Upper Intake Limit government standards. The guide also includes information about recommended forms, safety, purity and quality (MacWilliam, 2003). One of the most profound differences between MacWilliam?s compiled recommendations and the DRIs is the difference in the number of supplements: 39 vs. 26 respectively. The Comparative Guide standard includes additional nutrients, including many more antioxidants, based on decades of clinical research about their benefits. For example, the fat-soluble antioxidant Coenzyme Q10 that your body manufactures less of as you age is included. So is the fat and water-soluble antioxidant alpha lipoic acid that helps recycle other antioxidants such as vitamins C and E (Hendler, 2001).
Top Ranked Multiples for Optimal Health
In the latter half of MacWilliam's book he uses this ultimate blended standard to rank and compare 500 manufactured multiples. Of the five top-ranked multiples, only the Source Naturals multiples, Life Force and Élan Vitàl, are widely available at natural product stores and health outlets. And the new and improved Life Force formulation now rates higher than any of the products evaluated in the current edition of this guide (MacWilliam, 2004; & Mac-William, 2003). The ingredients that can be found in today's multiple supplements can vary greatly. But multiple choices don't have to lead to confusion. Health professionals, such as Lyle MacWilliam, understand the importance of remaining curious, evaluating the available research, and conferring with other scientists to determine the nutrients that support optimal health.
American Dietetic Association. 2001. Vitamin E: Disease Prevention for your Good Health. American Dietetic Association Website. Available at: Public/Other/index_nfs1001.cfm Fletcher, R. H., & Fairfield, K. M. 2002. Vitamins for Chronic Disease Prevention in Adults. JAMA. (23)287:3116-3129. Hendler, S. S., et al. 2001. PDR for Nutritional Supplements. Thomson Healthcare: Montvale. Pages 11-12, 17-21, 60-62, 103, 416-421, 486-498. JADA (Journal of the American Dietetic Association) 2001. Vitamin and mineral supplementation. J AM Diet Assoc.101: 115 Available at: Public/NutritionInformation/92_8343.cfm Levenstein, H. 1993. Paradox of Plenty: A Social History of Eating in Modern America. Oxford University Press: New York. Pages 13-15, 64-67. MacWilliam, L, et al. 2003. Comparative Guide to Nutritional Supplements. Northern Dimensions Publishing: Vernon. Pages 62-70. MacWilliam, L. 2004. Comparative Guide Individual Assessment of New Life Force Formulation. Warner, J. 2004. Few Follow '5 a Day' Fruit and Vegetable Rule. WebMD website. Available at: ent/Article/93/102158.htm Whitney, N. W., & Rolfes, S. R. (1998). Understanding Normal and Clinical Nutrition, 5th ed. Page 358. Whitney, E. N., & Rolfes, S. R. 2002. Understanding Nutrition. 9th ed. Wadsworth Thomson Learning: Belmont. Pages A, B, Y, 13-20, 55-56, 307, 331, 335-341, 401. Yang, S. 2004. Nearly one-third of the calories in the US diet come from junk food, researcher finds.
Cancer at the Millenium - the war on cancer entering its third decade...
June 13, 2005 10:23 AM
Cancer at the Millenium by Harriet Brown Energy Times, May 1, 1999
With the war on cancer entering its third decade, the necessity grows clearer for medical science to engage the enemy on several fronts. Until recently, high-tech medical weapons like vaccines and gene therapy, inspired by a flood of insights into the molecular basis of cancer, garnered most of the hope, hype, headlines and research money. The science was sexy and the prospect of a "cure" dramatic. But, today, advocates of prevention receive equal, if not greater, attention.
Improving our diets and prudently supplementing with vitamins and minerals, can deliver a major preventive impact. Contentious experts concede that at least a third (and probably more) of all cancers can be blamed on a combination of eating too much of the wrong foods and not enough of the right ones.
The Dietary Difference
Though cancer can progress rapidly once it leaps past its inception, it develops over many years and in several stages. Beneficial compounds in food and supplements may intervene along a line that runs from initial exposure to carcinogens to the final step into outright malignancy. Nutrients may: - counteract environmental poisons and the toxic byproducts of liver metabolism
The Big Picture The dietary guidelines advocated by the American Cancer Society and the National Cancer Institute (which generally coincide with those of most health organizations) may sound familiar: Eat plenty of fruits and vegetables. Get lots of fiber. Limit fat, especially animal fat. Go easy on meat and avoid the cured variety (they contain nitrites). If you drink alcohol, do it in moderation. Watch your total calories, and your weight. Pretty straightforward stuff.
Carotenoids, as their name suggests, are orange and red pigments in fruits and vegetables, most notably carrots and tomatoes, although they're also in everything from sweet potatoes to spinach and brussels sprouts (in the latter their distinctive color is mAsked by green chlorophyll).
Lycopene, a carotenoid found primarily in tomatoes, displays double the free radical-fighting activity of beta carotene, the most widely studied carotenoid. Of 72 studies looking at consumption of tomatoes or tomato-based products reviewed in the February 1999 Journal of the National Cancer Institute, almost half showed a significant reduction in one or more of a variety of cancers.
Research shows that lycopene may be best at lowering a man's risk of prostate cancer. A 1995 Harvard Medical School study (Journal of the National Cancer Institute 1995; 87: 1767-76) queried nearly 48,000 male health-care professionals about their consumption of fruits and vegetables. The only foods that reduced their risk of prostate cancer were, apparently, tomato sauce, tomatoes, pizza (tomato paste). For those who ate ten servings a week, risk dropped 45 percent; with four to seven servings, 20 percent. In animal studies lycopene decreased the number and size of mammary tumors (Eleventh International Symposium on Carotenoids, 1996).
Tomatoes are one of the richest sources of lycopene. Cooking tomatoes helps by releasing the lycopene from the plant cell walls. Also, the oil in tomato sauce enhances absorption in the stomach. Lycopene is also available in supplements.
Wine drinkers rejoiced when resveratrol, a constituent of the skin of red grapes, was found to protect their hearts (by blocking oxidation of LDL cholesterol and discouraging blood clotting). Now they have another reason to toast this potent antioxidant. When researcher John Pezzuto at the University of Illinois at Chicago screened about 1,000 plants for anticancer activity, he came up with one whose active ingredient turned out to be resveratrol. In lab tests it squelched both free radicals and inflammation, two well-known cancer inducers (Science, 6/10/97). In a study with mice, resveratrol reduced the number of skin tumors by up to 98 percent compared to control animals. Because the effective doses were high (Pezzuto estimates a person would have to quaff about five gallons of wine a day to get the equivalent) and because more than a drink or two a day may raise the risk of breast cancer, researchers don't recommend nondrinkers take up wine. But supplements of synthesized resveratrol (as well as grape juice) may help.
Saturated fat is an authentic dietary villain. Aside from clogging arteries, it's a suspected contributor to several cancers, though the evidence is greater for some cancers (prostate) than for others (breast cancer)
Of the two other main categories of fats, monounsaturated and polyunsaturated, mono seems benign, if not positively protective. For example, in a study of the influence of diet on breast cancer, Greek researchers discovered that women who consumed higher amounts of olive oil (which is mostly mono) were less likely to be afflicted with breast cancer (Journal of the National Cancer Institute 1995: 87; 110-116).
When it comes to polyunsaturated fats, however, things get complicated. The fat that predominates in corn, sunflower and other vegetable oils, called omega-6, has long been associated with cancer risk in animal experiments. Likewise the type found in margarines, trans fats, which are partially saturated vegetable oils. On the other hand, the omega-3 fats called EPA and DHA, which are found primarily in deep- and cold-water fish like cod, mackerel, and halibut, protect against both heart disease and cancer. In an epidemiological study covering 24 European countries, British researchers established that mortality rates for colon and breast cancers declined as fish and fish oil consumption rose (British Journal of Cancer 1996: 74; 159-64). And Finnish scientists discovered that the breast tissue of women who had breast cancer contained significantly less DHA and EPA than the breasts of healthy women (Nutrition and Cancer 1995: 24; 151-160).
Experts believe the omega-3s' anticancer effect derives from its ability to tamp down the prostaglandins that stimulate inflammation. Chronic inflammation unleashes a steady stream of free radicals, which can damage DNA and thereby trigger cancer. Omega-3s also help the liver detoxify potentially harmful substances.
Fortunately for the fish-phobic, nonmarine sources of omega-3 fats include flaxseed and hemp oils.
Minerals to Lower Cancer Risk
n Calcium: possibly protective against colon cancer. In a recent trial (New England Journal of Medicine, 1/14/99) researchers gave people with a history of precancerous colon polyps either two 600 mg calcium tablets a day or a placebo for nine months and found fewer polyps. n Selenium: powerful antioxidant and supporter of immunity. Researchers find that cancer rates in various regions is lowered when soil and vegetables contain more selenium
In a selenium-depleted area in China afflicted with one of the highest incidences of stomach and esophageal cancer mortality in the world, scientists Asked different groups to take various combinations of nutrients. After five years they found a significant reduction in the cancer rate among those who had gotten supplements of selenium, vitamin E and beta carotene (Biological Trace Element Research 1985; 7: 21-29). In the U.S. researchers studying the potential effectiveness of selenium supplementation for preventing nonmelanoma skin cancers came up with a surprise. The 200 mcg a day the subjects received for an average of 4.5 years had no impact on skin cancer but did significantly cut the rates of lung, colorectal and prostate cancers (Journal of the American Medical Association, 12/25/96).
More recently Harvard researchers determined that men with prostate cancer had much lower levels of selenium in their toenails (a measure of consumption) than healthy men (Journal of the National Cancer Institute, 8/119/98).
Cruciferous vegetables like broccoli, brussels sprouts, cauliflower and kale, have long been singled out for their association with protection against cancer. In a 1996 survey of 94 population studies and clinical trials focusing on consumption of cruciferous vegetables, 67 percent showed a reduced risk, the strongest link being with lung, stomach, colon and rectal cancers (Cancer Epidemiological Biomarkers 1996; 5: 733-748).
Scientists at Johns Hopkins showed that sulforaphane, from these plants, stimulates enzymes that help detoxify carcinogens generated in the liver. When they injected rats with a cancer-causing chemical, only 26 percent of the rodents pretreated with sulforaphane developed mammary cancer, compared to 68 percent of controls. Even animals who did come down with cancer had tumors that appeared later and smaller.
Other researchers have focused on a cruciferous-vegetable compound called indole-3-carbinol, which has proved especially effective against breast cancer cells. Recently, scientists at the University of California at Berkeley found that indole-3-carbinol, rather than acting as an anti-estrogen, (as had been thought), actually stops breast cancer cells by turning off a protein critical to their replication (Jrnal of Bio Chem, 2/13/98). Consequently, when treating certain forms of cancer, some doctors have paired indole-3-carbinol with the chemotherapy drug tamoxifen - which counteracts estrogen - and found that the combination has proven more potent than either separately.
Several decades ago British physician Denis Burkitt proposed that the low incidence of colon cancer among native peoples in South Africa was attributable to the fact that their diet was rich in fiber. The fiber, it was hypothesized, bulked up the stool, speeding its passage through the bowel and reducing the time carcinogens contact its lining; it also helped neutralize cancer-promoting bile acids.
This concept has been backed up by numerous studies. Recently, Harvard researchers sprinkled cold water on this idea, finding that an examination of the eating habits of more than 80,000 female nurses, could find no protective effect against colon cancer or precancerous polyps from consuming fiber (NEJM, January 21, 1999). Most experts' take on this apparent refutation: Maybe the "high fiber" intake in this case wasn't high enough, and this is just one study among many.
Fighting Breast Cancer
Fiber has also been linked to reduced rates of breast cancer. At first it was thought that if fat was a breast-cancer culprit, fiber might just be a marker for a low-fat diet. But a look at Finland undermined that idea: Finnish women eat both a lot of fat and a lot of fiber, and their breast cancer rate ranks much below that in the U.S., (where we eat gobs of fat and little roughage).
Fiber helps take estrogen out of circulation as it passes through the liver, while the isoflavones in many high-fiber plants and vegetables are themselves weak estrogens, which compete for slots on breast tissue's estrogen receptors. The special fiber in flaxseed oil called lignans act against estrogen in two ways: by binding its receptors and by inhibiting the enzyme that converts other hormones into estrogen.
Fiber comes in two basic forms, insoluble (e.g., wheat bran, celery, the skins of fruits and vegetables) and soluble (e.g., oat bran, citrus fruits, beans). Until a few years ago, scientists believed that cancer protection came mainly from insoluble fiber, but that thinking has turned around.
A soluble fiber called citrus pectin has been shown to halt the tendency of prostate, lung, breast and skin cancers to metastasize, or spread (e.g., Journal of the National Cancer Institute 1995; 87: 3448-353). Typically cancer turns deadly only when it gets into the bloodstream and invades new territory. Modified citrus pectin appears to stop this aggression by preventing cancer cells from attaching to healthy tissue.
While the name inositol hexaphosphate (IP6) sounds like a mouthful, many of us consume mouthfuls of this natural substance every day - in foods like corn, rice, whole-grain cereals, oats and wheat.
But now scientists have isolated IP-6 and found that this powerful antioxidant can slow the destructive cellular processes that lead to tumors. In a study published in Anti-Cancer Research (Nov/Dec 1998), scientists at the University of Maryland School of Medicine demonstrated that IP-6 could shrink liver tumors in laboratory animals.
The researchers believe that IP-6 can help prevent cancer and also be useful in lowering the risk of health problems like kidney stones and heart disease. Research like this continues to expand our knowledge of how to lower the risk of cancer. In the next millennium, with more and more information making its way into the media and onto websites, our power and the responsibility to reduce our risk of cancer will continue to grow and offer new possibilities.
CANDIDA YEAST INFECTIONS
May 18, 2005 06:00 PM
CANDIDA YEAST INFECTIONS
Many women are plagued with a constant battle with yeast infections. It is one of the most common reasons women visit a physician. It can be a very annoying condition often causing pain and discomfort. Candida albicans is commonly found on the skin, mouth, digestive tract and the vagina. Candida is a fungus found in the body all the time. Normally it does
not pose a threat because the numbers are kept under control by the beneficial bacteria (acidophilus). When an imbalance of the bacteria occurs, the candida can flourish sometimes leading to serious conditions. Antibiotic therapy, oral contraceptives, douching, and female hygiene sprays can all destroy the beneficial bacteria needed in the body and allow the candida to proliferate. Antibiotics are often used to treat yeast infections when they may be the initial culprit. Broad spectrum antibiotics can destroy the beneficial bacteria in the vagina allowing the yeast to grown. Using antibiotics to treat the condition can destroy the remaining good bacteria leading to a dependency on antibiotic treatment. Pregnancy can also cause disturbances in the intestinal flora.9 Whenever a disturbance in the bacterial flora occurs, it is important to take measures to reestablish the normal balance of friendly bacteria. One study found that women who consumed one cup daily of yogurt with the live Lactobacillus acidophilus cultures had a reduction in candida infections. The acidophilus does not kill the candida but helps to encourage an environment more suitable for the the beneficial bacteria to live and grow.10 Eileen Hilton M.D., a specialist at the Long Island Jewish Medical Center in New York, followed 11 women with chronic yeast infections. They ate one cup daily of yogurt rich in live Lactobacillus acidophilus. During the last six months of the study, the women averaged only one yeast infection.11
Another study done by Alexander Neri, M.D. a the Beilinson Medical Center in Israel followed 32 women with bacterial vaginosis. They were Asked to apply yogurt with Lactobacillus acidophilus twice a day for two weeks. Then they were told to skip a week and start again. After two days of treatment, all the women had recovered. All but four remained free of symptoms for two months.12
Other studies have also confirmed the benefits of Lactobacillus acidophilus in treating Candida albicans. Many beneficial results have been found using this natural form of treatment that enhances the body and encourages the growth of helpful bacteria rather than destroying all bacteria.
Multidophilus 180ct ...
May 18, 2005 05:30 PM
There is no doubt that antibiotics have saved numerous lives since their development. But many health care providers in the past have seen them as a panacea for all ailments including viral infections that are not affected by antibiotic therapy. They have been overused and with disastrous results. Antibiotics are used to help the body in fighting infection, but unfortunately, they also may encourage recurrent infections caused by a destruction of the good as well as the bad bacteria lowering the immune function and leading to a dependence on antibiotics. Because of an overuse and misuse of antibiotics, some forms of bacteria are now resistant to them. Diseases which were aided with antibiotic therapy are now resistant to the treatment. Antibiotics are sometimes prescribed by physicians even when they are not appropriate.4
Medical professionals almost felt guilty a few years ago when not prescribing some form of antibiotic when patients visited the office. After all, what good is a doctor if the patient does not leave with a cure. Fortunately, most doctors now know the detrimental affects that can follow excessive and inappropriate use of antibiotics. Most doctors now will be honest and up front with their patients when there is not a cure-all answer to their problem. An investigative reporter a few years ago visited a number of physicians around the country asking for antibiotics. It was interesting to note
that almost all of the physicians agreed to prescribing antibiotics upon the patients request even when it wasn’t warranted. In being confronted after, most replied that they had to do what the patient Asked in order to keep their practice flourishing. No wonder antibiotic overuse has resulted in drug-resistant strains of bacteria. The negative affects of antibiotics are well known. Antibiotics interfere with the growth of bacteria, both good and bad. But they are crafty creatures and have the ability of changing their chemistry and genes to avoid destruction by antibiotics. They want to survive and thrive. They grow at a very rapid rate allowing for a whole generation of drug resistant strains to develop in just a relatively short period of time. Alexander Fleming, who discovered penicillin, warned of the problem that could occur with resistant strains if antibiotics were overused.5 The weaker bacteria may be killed while the stronger endure. This causes the strong, resistant bacteria to invade and take hold in the body. Mitchell L. Cohen, a researcher with the National Center for Infectious Diseases at the Centers for Disease Control, issued this warning about antibiotics in 1992: “Unless currently effective antimicro b i a l agents can be successfully preserved and the transmission of drug-resistant organisms curtailed, the postantimicrobial era may be rapidly approaching in which infectious disease ward housing untreatable conditions will again be seen.” Patients, doctors, scientists and Acidophilus
public health officials must all play their part in finding ways to reduce reliance upon antibiotics.6 Lactobacillus acidophilus is one of the most essential bacteria found in the intestinal tract. It helps to keep the disease causing organisms under contro l . Antibiotics can reduce the quantities of good and bad bacteria often allowing negative organisms to flourish. Broad spectrum antibiotics are the worst offenders often making way for an overgrowth of yeast which can affect the entire body. The broad spectrum antibiotics work just as they are called, broadly throughout the body, to kill just about all the bacteria around. If an antibiotic is warranted, the most specific type for the condition should be tried first in order to protect as much of the normal intestinal flora as possible. When taking antibiotics, Lactobacillus acidophilus can be taken by mouth to help restore normal intestinal flora. Acidophilus will not interfere with the effectiveness of the antibiotics but protect and aid in the healing process. Antibiotic use should be minimized; used only when essential to health and survival. The beneficial bacteria are the first to be destroyed from the antibiotic therapy. Lactobacillus acidophilus can also help to fight the bad bacteria and organisms that invade the body.
Natures AntiBiotic - Multidophilus 12 Probiotic Supplement 100ct
Natures AntiBiotic - Multidophilus 12 Probiotic Supplement 50ct
Probiotic Multidophilus 180ct
Garlic for Treating Hypercholesterolemia - A Meta-Analysis ...
May 12, 2005 12:44 PM
Garlic for Treating Hypercholesterolemia - A Meta-Analysis of Randomized Clinical Trials
DATA SOURCES: Systematic literature searches were conducted on the MEDLINE, EMBASE, BIOSIS, Cochrane Library, AMED, and CISCOM databases. Manufacturers of commercial garlic preparations and experts in the field were Asked about published or unpublished trials.
STUDY SELECTION: Selected trials were required to state that they were randomized, double-blind, and placebo-controlled; use garlic monopreparations; include persons with mean total cholesterol levels of at least 5.17 mmol/L (200 mg/dL); and report total cholesterol level as an end point. There were no language restrictions.
DATA EXTRACTION: Two reviewers, blinded to key identifiers of each paper, independently extracted data in a standardized manner and assessed methodologic quality by using the Jadad scale. Discrepancies were settled through discussion.
DATA SYNTHESIS: In the 13 trials included in the meta-analysis, garlic reduced total cholesterol level from baseline significantly more than placebo (P < 0.01); the weighted mean difference was -0.41 mmol/L (95% CI, -0.66 to -0.15 mmol/L) (-15.7 mg/dL [CI, -25.6 to -5.7 mg/dL]). Six diet-controlled trials with the highest scores for methodologic quality revealed a nonsignificant difference between garlic and placebo groups; the weighted mean difference was -0.11 mmol/L (CI, -0.30 to 0.08 mmol/L) (-4.3 mg/dL [CI, -11.7 to 3.1 mg/dL]).
CONCLUSIONS: The available data suggest that garlic is superior to placebo in reducing total cholesterol levels. However, the size of the effect is modest and the robustness of the effect is debatable. The use of garlic for hypercholesterolemia is therefore of questionable value.
Study Says Supplements Could Save Billions in Health Care Costs
May 09, 2005 05:52 PM
Study Says Supplements Could Save Billions in Health Care Costs
A study released at a House subcommittee hearing in late September on the cost savings and health benefits of selected dietary supplements projected a $15 billion reduction in health care costs over a five-year period from calcium and folic acid.
The study, commissioned by the Dietary Supplement Education Alliance (DSEA) and conducted by the Lewin Group, found that the five selected supplements—omega-3 fatty acids, glucosamine, and saw palmetto along with calcium and folic acid—could make a significant impact on health care costs while positively affecting consumers’ health status. DSEA Asked the Lewin Group to put a dollar figure on the benefits of calcium and folic acid because the Food and Drug Administration (FDA) allows health claims on products containing these nutrients.
Since the study began, FDA also authorized qualified health claims on omega-3s, and the National Institutes of Health has implemented large-scale studies of saw palmetto and glucosamine.
“Many industry experts have long believed that dietary supplements provide consumers with long-term health benefits by reducing the incidence of debilitating health problems, and this study proves it,” said Elliott Balbert, president and CEO of Natrol, Inc. (Chatsworth, CA) and president of DSEA. “The findings provide evidence to support both the cost savings and quality-of-life benefits of these particular supplements.”
DSEA commissioned the Lewin Group to critically review the research literature on the five supplements for consistency, validity, and impact (i.e., size of the effect; to develop estimates of the potential health care expenditure savings that could result from daily use of two of the supplements; and to suggest areas of future research for supplements where there is emerging evidence. The Lewin Group arrived at the $15 billion figure by focusing on two specific health issues: hip fractures (including hospital and nursing facility expenses) in the case of calcium along with vitamin D, and neural tube defects in the case of folic acid. Joan DaVonzo, vice president of the Lewin Group, said at a news teleconference following the Sept. 22 hearing that the savings in health care costs from supplementing calcium intake might be even larger than the projected $13.9 billion if other types of fractures were included.
Dr. Jeffrey Blumberg, professor of nutrition at Tufts University and one of the witnesses who testified before the House Subcommittee on Human Rights & Wellness chaired by Rep. Dan Burton (R-IN), told reporters the health benefits—and potential cost savings—of folic acid supplementation went far beyond the $1.1 billion estimate for neural tube defects. He said folic acid has been shown to help prevent other types of birth defects as well as reducing the risk of cardiovascular disease and certain types of cancer. “It’s not a one nutrient/one disease relationship,” Blumberg said.
“Research shows that the typical American diet does not always provide a sufficient level of nutrients. This study just reveals the tip of the iceberg in the ability of supplements to contribute to a healthier America,” said Elwood Richard, president and founder of supplement manufacturer NOW Foods (Bloomingdale, IL), in response to the study.
DaVonzo acknowledged that the potential for the five supplements studied went beyond the dollar figures projected in the study. For instance, in the case of saw palmetto and its reported prostate health benefits, “The impact could be huge,” she said.
“It’s no surprise to anyone in the industry that dietary supplements are safe, affordable, and effective, and this study not only confirms that statement, but will, more importantly, reach an audience well beyond industry,” said David Seckman, executive director and CEO of the National Nutritional Foods Association. “An even more critical finding is the fact that dietary supplements can dramatically cut health care costs if used regularly—a point that won’t be lost on any American consumer, the media, and lawmakers aware of the staggering—and rising—cost of health care in this country.”
To help spread the message beyond the halls of Congress, DSEA prepared an audio news release and was organizing a satellite media tour. DSEA vice chairman Jon Benninger said the hope was to commission followup studies on other nutrients “as funding allows.” Vitamin Retailer Magazine, Inc., 431 Cranbury Road, East Brunswick, NJ 08816 //www.oprmagazine.com/