CoQ10 for Heart Health

 

More than 40% of all deaths in the U.S. are from cardiovascular disease (CVD). You have a greater chance of dying from heart disease than from cancer, AIDS, diabetes, and accidents combined. More than 2,600 Americans die each day of CVD – an average of 1 death every 33 seconds. One in 5 men and women have some form of CVD. If all forms of major CVD were eliminated, life expectancy would rise by almost 7 years.

One of the most – if not the most – important things people can do to improve their overall health and life expectancy is to improve their heart health. Diet, exercise, and the wise use of dietary supplements can improve heart health dramatically. One dietary supplement that’s extremely beneficial to heart health is coenzyme Q10 (CoQ10).

 

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone. That’s because CoQ10 is ubiquitous and exists everywhere there is life. CoQ10 is vital to adenosine triphosphate (ATP) production. ATP is the energy-rich compound used for all energy-requiring processes in the body. Although COQ10 is produced by the body and exists in some dietary sources, these levels may be insufficient to meet the body’s requirements. CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. Also, some drugs, especially a group of cholesterol-lowering prescription drugs known as “statin,” (Pravachol, Zocor, Lipitor, etc.) significantly reduce CoQ10 levels in the body.

 

Q. For what health conditions is CoQ10 used?

A. CoQ10 is beneficial in treating and preventing CVD and conditions such as high blood pressure, atherosclerosis (hardening of the arteries), angina, and congestive heart failure (CHF). It’s been shown that heart attacks tend to occur when CoQ10 levels are low in the body. In addition, CoQ10 is beneficial for diabetes, immune dysfunction, cancer, periodontal disease, prostate cancer, and neurological disease.

 

Q. Why is CoQ10 especially important to heart health?

A. The heart is one of the most metabolically active tissues in the body. In the average person, the heart propels 2,000 gallons of blood through 65,000 miles of blood vessls by Beating 100,000 times each day. Thus, it requires large amounts of uninterrupted energy. Heart cells have a greater number of mitochondria, and subsequently, more CoQ10 than any other type of cell. Each heart cell can have thousands of mitochondria to meet these energy demands.

 

Mitochondria are highly specialized structures within each cell and are often referred to as cell powerhouses. These tiny energy-produces produce 95% of the energy the body requires. The number of mitochondria in a cell depends on its function and energy needs. A cell’s ATP production is dependent on adequate amounts of CoQ10.

 

Heart disease patients are commonly CoQ10 deficient. Correcting such deficiencies often can produce amazing results. The presence of supplemental CoQ10 is a key to the heart’s optimum performance.

In people who have had a heart attack (myocardial infarction), CoQ10 assists in repairing the heart muscle and restoring heart function. This is due to increased ATP production.

 

Q. What studies support this fact?

A. A 1998 study found CoQ10 can provide rapid protective effects in patients with a heart attack if administered within three days of the onset of symptoms. The study focused on patients admitted to the hospital with an acute myocardial infarction (AMI) diagnosis. Seventy-three patients received CoQ10 (120 mg/d). The study’s control group consisted of 71 similarly matched patients with acute AMI. After treatment, angina pectoris (severe chest pain signifying interrupted blood flow to the heart), total arrhythmias (dangerously irregular heartbeats), and poor function in the left ventricle (the essential chamber of the heart) were significantly reduced in the CoQ10 group compared to the placebo group. Total deaths due to sudden cardiac failure and nonfatal heart attacks also were significantly reduced in the CoQ10 group compared with the placebo group.

 

In another study, CoQ10 was studied in 109 patients with high blood pressure (hypertension). The patients were given varying doses of supplemental CoQ10 with the goal of attaining a certain blood level (greater than 2.0 mcg/l). Most patients were on medications to treat hypertension. Half the patients were able to stop taking one to three antihypertensive drugs at an average of 4.4 months after starting CoQ10. Only 3% of patients required the addition of one antihypertensive drug. The 9.4% of patients who have echo cardiograms, performed both before and during treatment, experienced a highly significant improvement in heart wall thickness and function. This improvement was directly attributed to CoQ10 supplementation.

 

Congestive heart failure (CHF) is a debilitating disease that affects 5 million people in the U.s. It causes edema, difficult breathing, and impaired circulation. In another study, CoQ10 restored healthy heart function in CHF patients. Patients received 100 mg of CoQ10 or a placebo twice daily for 12 weeks. Before and after the treatment period, the investigators introduced a catheter into the right ventricle of patients’ hearts to determine the degree of CHF damage to the heart muscle. The patients’ heart muscles at rest and work improved significantly. The researchers concluded CHF patients would greatly benefit from adjunctive CoQ10 treatment.

 

Q. I’ve heard that CoQ10 can also help people who have neurological diseases. Is this true?

A. Yes, it is. CoQ10 has been studied for its ability to improve the health of individuals with amotrophic lateral sclerosis (ALS), Parkinson’s disease, and Huntington’s disease. A recently completed study sponsored by the National Institutes of Health showed that CoQ10 caused a slowing of the progression of Huntington’s disease, a devastating and degenerative disease that is always fatal. In fact, no other medication, drug, or nutritional supplemental has ever been shown to cause a decline in the progression of this terrible disease.

 

The study compared CoQ10 against remacemide (an investigational HD drug made by AstraZeneca Pharmaceuticals), in 347 HD patients who were in the early stages of the disease. Remacemide blocks glutamate, the neurotransmitter scientists think may cause the death of brain cells that occurs in Huntington’s disease. While remacemide had no effect on the progression of HD, CoQ10 showed a trend toward slowing the disease by an average of 15%. This meant the HD group taking CoQ10 was able to handle every day activities of life a little longer than the patients taking remacemide or a placebo. They also were able to focus their attention better, were less depressed, and less irritable. The 15% slowing of decline means that CoQ10 can result in about one more year of independence for HD patients. Needless to say, the gift of an additional year of health in the lives of HD patients is incredibly significant.

 

Because of these impressive results with HD, researchers are hopeful that the studies of CoQ10 in those with ALS and Parkinson’s disease will similarly have a positive effect on the symptoms and/or progression of these neurological disorders, too.

 

Q. Why is it crucial for a CoQ10 supplement to cross the blood-brain barrier?

A. The brains’ blood vessels are composed of cells with extremely tight junctions. These junctions form the blood-brain barrier, which restricts what can pass from the bloodstream into the brain. While this barrier protects the brain, it can be a significant obstacle to central nervous system therapy. To leave the bloodstream and reach the brain cells, a substance must pass through the tightly connected cells of the capillary walls. Only substances with unique solubilities or those with a transport system can cross the blood-brain barrier to a significant degree. As a result, crossing the blood-brain barrier presents a significant challenge to supporting neurological health.

 

While most CoQ10 supplements enter the bloodstream and increase blood serum levels, only special forms of CoQ10 have been shown to cross the blood-brain barrier. For CoQ10 to enter the mitochondria within the brain, CoQ10 must first cross the blood-brain barrier to produce significant neurosupportive clinical results.

 

Q. How can one supplement have applications for neurological diseases, heart health, and even the immune system?

A. Supplements often have more than one function, especially when it’s a substance like CoQ10, which is present in all parts of the body. All nucleated cells (most cells other than red blood cells) have mitochondria and all cells require energy to function. CoQ10 is vital to ATP production. Thus, CoQ10 has applications not only in neurological (neurons or nervous system cells) and cardiac health (myocardium or heart tissue), but also for the immune system.

 

Q. Are all CoQ10 supplements created equal? Doesn’t CoQ10 just have to get into the bloodstream to be effective?

A. There are some important distinctions among CoQ10 products, as they vary greatly in quality and absorbability. It’s crucial to find a CoQ10 product that’s:

 

1. Scientifically shown to absorb through the digestive tract, cross cellular membranes, and increase mitochondrial levels of CoQ10. Chewable forms of CoQ10 provide rapid bioavailability and absorption. Serum level determination of CoQ10 in the bloodstream is not necessarily the most important measure of efficacy. For a CoQ10 supplement to be fully effective, it must cross the cellular barrier and raise intracellular CoQ10 levels. A key indicator of effective CoQ10 supplementation is its presence in cell mitochondria.

 

2. The natural form of CoQ10. The natural process uses living organisms. CoQ10 also can be synthesized by a chemical process, which produces a distinctly different product that contains chemical compounds not found in the natural form.

 

3. Formulated with ingredients that provide the transport system CoQ10 needs to cross cellular membranes and the blood-brain barrier. Not all forms of CoQ10 have been scientifically proven to cross cell membranes and the blood-brain barrier. Some prestigious groups that have investigated this issue include researchers at Massachusetts General Hospital and Harvard Medical School.

 

4. Studied by respected organizations, with research published in peer-reviewed journals by reputable scientists.

 

Q. How much CoQ10 should I take?

A. Take 100 to 200 mg of CoQ10 daily, depending on your family history of heart disease and personal heart disease experience.

 

CoQ10’s safety has been evaluated. Dosages in studies have ranged from 100 mg to 1,200 mg per day. To date, no toxicities have been reported. Occasional mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.

 

Q. What are some other heart-friendly supplements?

A. CoQ10 is an excellent supplement for overall cardiovascular health, as in L-carnitine. L-carnitine is the naturally occurring form of carnitine that’s found in food and synthesized in the body. Much of the body’s L-carnitine is found in the heart and skeletal muscle, tissues that rely on fatty acid oxidation for most of their energy. Nearly 70% of the energy needed for heart function is derived from fatty acid breakdown. Proper L-carnitine supplementation transports fatty acids into cell mitochondria, where it’s burned for energy. L-carnitine is an excellent addition to CoQ10, especially for people with heart disease, and has been shown to improve many symptoms associated with CVD. In one study, people who had experienced one heart attack received either L-carnitine or placebo. The L-carnitine group had a statistically significant reduction in second heart attacks, and improved overall survival.

 

Q. What supplements support healthy blood pressure and cholesterol?

A. In addition to maintaining overall cardiovascular health, it’s also important to address your essential fats/lipids levels and healthy circulation/blood pressure. Fish oil supplements can significantly reduce blood pressure, cholesterol, and homocysteine levels. Choose a supplement that’s a rich source of EPA and DHA, omega-3 fatty acids naturally obtainable in fish oil. Find a product that’s been clinically studied and purified to ensure it contains the beneficial active constituents of the whole oil, while removing any dioxins, DDT, PCBs, or heavy metals, toxins present in some commercial fish oil preparations. An enteric-coated garlic product that provides a minimum of 5,000 mcg of beneficial allicin supports healthy blood pressure and circulation. And magnesium, niacin, vitamin E, folic acid, hawthorn extract, and L-cysteine provide overall nutritional support to the heart and vascular system.

 

Conclusion

CoQ10 is not the only answer to the complex issues of heart disease, neurological disease, or immune dysfunction; however, research indicates that it’s a bigger piece of the puzzle than physicians and scientists ever imagined. The more we study this naturally occurring compound, the more benefits we find.

The key to this supplement is the manufacturing quality. For safety and overall effectiveness, use a CoQ10 product that’s supported by product-specific research from reputable institutions. Choose tested products from a well-respected company to increase your potential to achieve and maintain heart and blood vessel health.

Supplementation with clinically studied products can have a major impact on your heart’s health and strength. However, no supplement replaces the need to eat a healthful diet low in refined foods (especially sugar), and saturated fats, and to exercise your most important muscle – your heart – on a regular basis.

 

 

Regulating Blood Pressure Naturally

 

High blood pressure (also known as hypertension) affects about 65 million Americans, or about 1 in 3 adults. There are many potential causes of hypertension, but not necessarily any symptoms. In fact, 30% of the people who have high blood pressure don’t even realize it.

In other words, just because you don’t have symptoms doesn’t mean you don’t have high blood pressure. That’s why it’s called “The Silent Killer.” And, make no mistake about it: high blood pressure is dangerous. It is the number one modifiable cause of stroke. Just lowering blood pressure reduces the chance of stroke by 35 to 40 percent. Other conditions, including heart attack and heart failure can be reduced from 25 to 50 percent, respectively.

In this issue of Ask the Doctor, we’re going to talk about high blood pressure and an exciting natural treatment for lowering blood pressure safely and effectively.

Of course, changing blood pressure numbers depends, in a large part, on the choices we make every day – how much we exercise, the foods we eat, and our lifestyle overall. But, for those times we need extra help, there is a new, scientifically-studied supplement to help us along our path to better health and lower blood pressure.

 

Blood pressure guidelines from the National Heart, Lung, and Blood Institute.

Category	Systolic (mm/Hg)	Diastolic (mm/Hg)	Result
Normal	Less than 120	And Less than 80	Excellent!
Prehypertension	120-139	Or 80-89	Make changes in eating and drinking habits, get more exercise and lose any extra pounds.
Hypertension	140 or higher	Or 90 or higher	You have high blood pressure. Talk to your healthcare professional on how to control it.

 

Q. What exactly is blood pressure?

A. Blood pressure is divided into two parts, systolic and diastolic. Systolic is the pressure of the heart Beating. Diastolic is the pressure of the heart and vessels filling. When blood pressure numbers are written out, like “120/80,” 120 is the systolic pressure and 80 is the diastolic pressure. The unit of measurement for blood pressure is millimeters of mercury, written as “mm/Hg.”

 

Q. What is considered high blood pressure?

A. A person’s blood pressure can naturally vary throughout the day – even between heartbeats.

However, if the numbers are consistently high (over 120 systolic and 80 diastolic), after multiple visits to your healthcare practitioner, you may have either pre-hypertension or high blood pressure.

Young arteries and arteries that are kept young through healthy diet and exercise are typically more elastic and unclogged. Blood flows through them easily and without much effort. However, as we age, our arteries become more prone to plaque buildup (due to diets high in saturated fat and sedentary lifestyles) and don’t “flex” as well under pressure. The result is faster blood flow, all the time. Over the long term, it damages heart tissue, arteries, kidney and other major organs.

To get a better idea of high blood pressure, compare your arteries to a garden hose. When unblocked, a garden hose allows water to flow through it quickly and easily – without any real rush or stress. However, if you block the end of the hose with your thumb, closing it off even a little, water rushes out much more quickly.

For many years, high diastolic pressure was considered even more of a threat than high systolic pressure. That thinking has changed somewhat but high diastolic numbers could still mean organ damage in your body – especially for individuals under 50.

 

Q. What courses high blood pressure?

A. The reasons for hypertension aren’t always clear. However, there are lifestyle factors that contribute to high blood pressure that you can change:

 

Body type: Weight isn’t always a reliable indicator of whether or not you’ll have high blood pressure – but the type of weight is. Lean body mass – muscle – doesn’t increase blood pressure levels the way that fat can. However, fat body mass, especially fat around your middle, can contribute to high blood pressure.

 

Sedentary lifestyle: Too often, many of us sit down all day at work, and then sit down all night at home. Over time, this inactivity usually leads to weight gain, making the heart work harder to pump blood through the body. In a way, it almost seems contradictory, but inactivity usually leads to higher heart rates.

 

Sodium intake: Sometimes it’s hard to believe how much salt there is in processed foods. However, salt intake in itself is not necessarily bad. For people with a history of congestive heart failure, ischemia, and high blood pressure, sodium is definitely out. For those individuals, it leads to more water retention, which increases blood pressure. (Salt’s effect on water retention is one reason that so many sports drinks have fairly high sodium content – the sodium in the drink prevents your body from sweating out too much water.) But, for healthy individuals, moderate salt intake, especially a mixed mineral salt like sea salt or Celtic salt (good salt should never be white) is fine.

 

Low potassium intake: Unlike sodium, potassium is a mineral which most Americans get too little of. Potassium helps regulate the amount of sodium in our cells, expelling excess amounts through the kidneys. Low levels of this mineral can allow too much sodium to build up in the body.

 

Heavy alcohol intake: Having three or more alcoholic drinks a day (two or more for women) nearly doubles an individual’s chance of developing high blood pressure. Over time, heavy drinking puts a lot of stress on the organs, including the heart, liver, pancreas and brain.

 

Unhealthy eating: Eating a lot of processed or fatty foods contributes to high blood pressure. Adapting a diet that is rich in fruits and vegetables, whole grain products, fish, nuts and magnesium and potassium (like the Dietary Approaches to Stop Hypertension, known as the “DASH” diet) can bring it back down.

 

Smoking: If you smoke, stop. Smoking damages the heart and arteries – period. Nicotine constricts blood vessels, increases heart rate, and raises blood pressure. This in turn, increases hormone production and adrenaline levels, further stressing the body.

 

As if that weren’t bad enough, the carbon monoxide in cigarette smoke replaces the oxygen in the blood, making the heart work even harder to make up the difference. Since the effect of a single cigarette can last for an hour, smoking throughout the day leads to continuously revved-up blood pressure.

 

Some of these factors might sound like a lot to overcome. The important thing to remember is that all of these behaviors are changeable. If you have high blood pressure, modifying any of these can significantly lower blood pressure as part of an overall plan.

 

Q. What are the blood pressure numbers I should see?

A. Experts consider healthy blood pressure numbers to be 115/75 mm/Hg. The reason? They found that the risk of cardiovascular disease doubles at each increment of 20/10 mmHg over 115/75 mm/Hg. Even small jumps in blood pressure numbers increase the risk of stroke and heart attack.

 

Q. Okay, so other than diet, exercise and lifestyle changes are there other natural ways or supplements I can use to lower my blood pressure?

A. Yes, in fact, you hear about some of them in the news all the time – fish oil, CoQ10, and garlic. As effective as these symptoms are, they typically lower systolic pressure much more than diastolic pressure.

However, there is a blend of scientifically and clinically studied natural ingredients that lower high blood pressure separately, and work even better when they’re combined. This combination blend contains: dandelion leaf extract, lycopene, stevia extract, olive leaf extract and hawthorn extract.

Every one of these ingredients has been studied and recommended for years. But now, a scientific study on a supplement that combines them in one synergistic formula shows encouraging results for lowering systolic and diastolic blood pressure.

Let’s take a look at each:

Stevia leaf extract	Supports healthy blood pressure levels according to clinical studies.
Hawthorn extract	Supports the heart and balance sodium and fluid levels.
Olive leaf extract	Scientifically shown to support healthy blood pressure.
Dandelion leaf	Helps reduce fluid retention
Lycopene	Clinically shown to support arteries, circulation and heart health.

 

Stevia:

Stevia (Stevia rebaudiana) originated in South America, and is often used as a sweetener. Glycosides in stevia, particularly stevoside, give the plan its sweet flavor 0 anywhere from 100 to 200 times sweeter than sugar.

The leaf of stevia is considered the medicinal part of the plant. Research shows that extracts of the leaf relax arteries and help prevent the buildup of calcium on artery walls – keeping them healthy and reducing blood pressure.

In a long-term, randomized, placebo-controlled clinical study, stevia reduced systolic and diastolic blood pressure. On average, participants’ blood pressure reduced from baseline 150 mm/Hg to 140 mm/Hg systolic and 95 mm/Hg to 89 mm/Hg diastolic.

And, in another double-blind, placebo-controlled clinical study, stevia lowered blood pressure quite significantly – by an average of 14 millimeters of mercury in both systolic and diastolic readings. Those are impressive numbers!

Despite its role as a sweetener, stevia may have a side benefit to for those with hypertension – blood sugar regulation. Scientific studies show that extracts of stevia regulated blood sugar and reduced blood pressure.

A clinical study showed that stevia extract actually improved glucose tolerance by decreasing plasma glucose levels during the test and after overnight fasting in all participants. Regulating blood sugar is very important for those with high blood pressure. When blood sugar levels are high, blood vessels are inflamed. Many people with diabetes have high blood pressure as well. In a paired, cross-over clinical study, stevioside (one of the compounds in stevia) reduced glucose levels in individuals with type 2 diabetes. Further scientific studies show that stevia works to control blood sugar levels by stimulating insulin secretion by the pancreatic beta cells. It shows great potential in treating type 2 diabetes. Further scientific studies show that stevia works to control blood sugar levels by stimulating insulin secretion by the pancreatic beta cells. Its shows great potential in treating type 2 diabetes as well as hypertension.

 

Hawthorn extract:

Hawthorn (Crataegus spp. Oxycantha) has been used since ancient ties as a medicinal herb – even being mentioned by the Greek herbalist Dioscorides, in the first century AD. Traditionally, it has generally been used for support of the heart. Modern research points to bioflavonoid-like complexes in hawthorn leaf and flower that seem to be most responsible for its benefits on cardiac health, like blood vessel elasticity.

The bioflavonoids found in hawthorn include oligomeric procyanidins, vitexin, quercetin, and hyperoside. They have numerous benefits on the cardiovascular system. Hawthorn can improve coronary artery blood flow and the contractions of the heart muscle. Scientific studies show that the procyanidins in hawthorn are responsible for its ability to make the aorta and other blood vessels more flexible and relaxed, so that blood pumps more slowly and with less effort – sparing the cardiovascular system such a hard workout.

The procyanidins in hawthorn also have antioxidant properties – protecting against free radical cellular damage.

And, hawthorn may also inhibit angiotensin-converting enzyme. Angiotensin-converting enzyme is responsible for retaining sodium and water, and may have roots in our evolutionary development. It influences blood vessel contraction and dilation, sodium and water balance and heart cell development – just about everything that has to do with blood pressure. This may have developed as a way of dealing with periods of drought and stress. By narrowing the blood vessels, the body could guarantee an adequate supply of blood and focus on repairing tissue.

Unfortunately, that can lead to real problems these days. Since many of us live in an industrialized society, and frequently have pretty sedentary lifestyles, conserving sodium just makes the conditions for high blood pressure that much worse.

Like the other ingredients in this combination, hawthorn showed benefits on other body systems, too. In clinical and scientific studies, it not only lowered blood pressure, but also showed anti-anxiety properties and regulated blood sugar.

 

Olive leaf extract:

Olive leaf (Olea europaea) comes up again and again in scientific and clinical studies as having beneficial effects on hypertension. One of olive leaf’s most beneficial compounds is oleuropein – the same compound that makes olive oil so helpful in reducing blood pressure. Here again, we have to look at the traditional Mediterranean diet, which features voluminous use of olives and olive oil. Not surprisingly, blood pressure is generally much lower in Greek and Italian populations.

But it’s not just the diet – scientific studies showed that oleuropein lowered blood pressure by relaxing the blood vessels and prevented buildup of plaque in arteries. Plus, whether in olive leaf extract or in olive oil, oleuropein works as an antioxidant, too.

 

Dandelion leaf extract:

Dandelion (Taraxacum offinale) leaves provide a healthy supply of vitamins, much like spinach. In fact, although it has become the bane of North American gardeners and lawn owners, dandelion greens are a component of many gourmet salads.

Medicinally, dandelion has been used for centuries, dating back to ancient Greece. Leaves intended for medicinal use are harvested before flowering, to ensure the most nutrients.

They are a very rich source of vitamin A, and contain vitamin D, vitamin C, carious B vitamins, iron, silicon, magnesium, zinc and manganese, too. Dandelion leaves produce a diuretic effect in the body, similar to a prescription drug. Since one of dandelion leaf’s traditional uses was the treatment of water retention, it’s really not too surprising. Dandelion leaf is also rich in potassium – one of the vital minerals many Americans lack in their diet. So, even though it may act as a diuretic, it replaces more potassium than the body expels.

The diuretic effect of dandelion can relieve hypertension by drawing excess water and sodium from the body and releasing it through the kidneys as urine. Getting rid of extra water and sodium allows the blood vessels to relax – lowering blood pressure.

 

Lycopene:

If a nutrient can be called exciting, lycopene is it. Lycopene is found mostly in tomatoes and processed tomato products, like pasta and pizza sauce. Related to beta-carotene lycopene shows great antioxidant abilities among its many talents. In fact, it shows even greater free-radical scavenging properties than beta-carotene, its more famous cousin. Healthy intakes of lycopene can guard against a variety of chronic conditions, including lowering LDL (bad) cholesterol, lowering homocysteine levels and reducing blood platelet stickiness that can lead to clogged arteries. It’s even being studied for its protective effect against prostate cancer.

And, for proof, you don’t have to look too far to see the amazing effect lycopene intake can have on health. The Mediterranean diet provides an excellent example. Its high intakes of vegetables, (tomatoes, of course, playing a central role) fish, and whole grains improve cholesterol levels and lower blood pressure. The research on lycopene as a stand-alone nutrient has been compelling. A randomized clinical trial found that not having enough lycopene was associated with early thickening of the arteries.

So, it makes sense that other clinical trials, showed that higher intakes of lycopene frequently meant less thickening of arteries, and a reduced risk of heart attack. In one study, the risk of heart attack was 60% lower in individuals with the highest levels of lycopene. In a multicenter study, similar results were found – men with the highest levels of lycopene had a 48% lower risk of heart attack.

 

Q. What can I expect taking this herbal combination?

A. You should notice both systolic and diastolic numbers lowering in about two weeks. The scientific study showed that for pre-hypertensive and stage I, (early hypertensive individuals) this combination for ingredients lowers both systolic and diastolic blood pressure.

When you’re taking herbs to support your blood pressure, it’s important to keep it monitored so you have an accurate reading (and record) of your numbers. If you need to, you can pick up a home blood pressure monitoring device. These can retail for anywhere from $30 all the way up to $200, but buying one in the $30 to $50 range is a good idea and money well spent. Consider taking the machine to your local doctor’s office or fire department to have it tested for accuracy against a professional blood pressure monitor. See the chart below for tips on getting an accurate reading from a home monitor.

 

Tips for Accurate Blood Pressure Monitoring:

-Relax for about 5 to 10 minutes before measurement.

-If you have just come inside from cold outdoors allow yourself to warm up.

-Remove tight-fitting clothing and jewelry.

-Unless your physician recommends otherwise, use left arm to measure pressure.

-Sit, don’t stand.

-Remain still and do not talk while using the monitor.

 

Q. Are there any side effects?

A. There were no side effects noted in the study. However, because of the mild diuretic effect of dandelion leaf extract, you may notice an increase in trips to the bathroom. It’s always important to make sure you don’t get dehydrated, so you may want to drink more water during the day.

 

Conclusion:

High blood pressure doesn’t happen overnight. As we get older, the likelihood of developing hypertension increases. And, stressful, fast-forward lifestyles, bad diets and no exercise conspire to raise our blood pressure.

 

In my own practice I have helped patients move toward a healthier lifestyle, including diet, exercise, and blood-pressure reducing supplements. They live better, more vibrant lives as a result, and their blood pressure normalizes. It really can happen – you can bring your blood pressure back to normal, and this combination of scientifically and clinically validated ingredients can help.

Controlling Diabetes with Nutritional Supplements

 

Perhaps no other disease is as closely linked to nutrition as diabetes. Not only doe nutrition play a role in its development, nutrition is also one of the disease’s most powerful treatments.

 

Because of this strong and critical connection to nutrition, researchers have carefully studied the use of nutritional supplements in the treatment of the disease. They found that many vitamins, such as vitamin C and the B vitamins, minerals such as chromium, as well as herbs like Gymnema sylvestre, can safely, effectively, and naturally lower blood sugars and help prevent diabetic complications.

 

What is even more important, however, is that these vitamins, minerals, and herbs can be combined together in a scientifically validated diabetic formula to work synergistically. That means their combined effectiveness is even more powerful. Like a group of good friends, these vitamins, minerals, and herbs do their best work when they are all together.

In this issue of Ask the Doctor, we will talk about powerful vitamins, minerals, and herbs combined in a scientifically validated formula that people with diabetes can use every day.

 

But before we get into the specific formula, we need to first talk about diabetes.

 

Q. What exactly is diabetes?

 

A. When we eat, the process of digestion breaks down our food into nutrients. Most of the food we eat is broken down into sugar (also called glucose). The sugar enters the bloodstream for delivery throughout the body and is then called blood sugar.

 

Insulin, a hormone that helps metabolize blood sugar, is made in the pancreas-a long, skinny gland located behind the stomach. Insulin takes blood sugar from the bloodstream and delivers it into the cells that make up the various organs in our body, such as our heart, lungs, and kidneys. The sugar provides energy to the cells to keep our hearts Beating, our lungs breathing, and our kidneys excreting.

 

Type 1 diabetes, sometimes called insulin-dependent or juvenile diabetes, most often starts in childhood. In this type of diabetes, the pancreas no longer makes insulin. The sugar stays in the blood instead of going into the cells where it is needed. Because of this, all people with Type 1 diabetes have to take at least one shot of insulin every day just to stay alive.

 

Type 2 diabetes most often starts in adults and is also the most common kind. About 90 to 95 percent of all people with diabetes have Type 2. In Type 2 diabetes, the pancreas is usually producing enough insulin. However, the body does not use it effectively. The condition known as “insulin resistance” occurs when the cells do not respond to (resist) insulin’s attempt to enter with glucose. The pancreas responds by producing more and more insulin. When the cells do not respond, high levels of glucose build up in the blood, leading to Type 2 diabetes. Almost everyone with Type 2 diabetes also is insulin resistant. Because the insulin is left unused, the pancreas thinks it isn’t needed and may eventually stop making it. People with Type 2 diabetes often need to take prescription drugs to lower blood sugar levels if dietary and lifestyle changes are not enough to control the problem.

 

In both types of diabetes, the sugar stays in the bloodstream instead of going into the cells where it is needed and belongs. When blood sugar builds up in the blood, it causes two problems. First, the cells become starved for energy. And, over a period of time, high blood sugar levels can damage the blood vessels, nerves, eyes, and kidneys.

 

Q. What causes diabetes?

 

A. While scientists aren’t exactly sure why Type 1 diabetes happens, they do know the immune system is involved. A healthy immune system protects us from diseases caused by infections, such as colds or the flu, as well as diseases that start in our own cells, such as cancer. For some reasons, in certain people, the immune system becomes confused and begins attacking and destroying the cells in the pancreas that makes insulin.

 

Scientists aren’t exactly sure why Type 2 diabetes happens either; however, they have identified that it occurs most often in certain individuals. About 80 percent of people with type 2 diabetes are overweight, have high blood pressure, and have high cholesterol levels in their blood.

 

Q. What are the symptoms of diabetes?

 

A. Type 1 diabetes develops very quickly. The classic signs of diabetes include:

 

-Frequent urination, because the body is trying to get rid of the excess sugar in the blood

-Intense thirst, because the body needs to replace the fluid lost through the urine

-Increased hunger, because the cells need nutrients

-Weight loss, because without insulin, the body begins to starve

 

The onset of Type 2 diabetes is often very gradual and may develop without any symptoms at all. Sadly, the diagnosis most often is made only after a complication of the disease happens.

 

Q. What are the complications of diabetes?

 

A. The complications of diabetes happen in both types of the disease. All diabetic complications are caused by chronically high blood sugars. The longer your blood sugar levels are elevated, the greater your chances are of having complications.

 

Circulation problems

 

High blood sugar damages blood vessels. When high levels of sugar are continuously in the blood, the blood vessels become thicker and less flexible, causing poor circulation. Poor circulation can impair healing, especially on the feet and lower legs. High blood sugar also causes higher levels of fat in the bloodstream. The fat clogs and narrows the blood vessels. Partial blockages deprive the heart of some necessary nutrients. A complete blockage can result in a heart attack, heart pain (called angina), or stroke.

 

Nerve damage

 

Nerve damage makes it hard for your nerves to send messages to the brain and other parts of the body. It may cause you to lose feeling in parts of your body or have a painful pins-and-needles-like feeling. While nerve damage most often affects the feet and legs, it can also affect other parts of the body.

 

Eye problems

 

Diabetes can damage and weaken the small blood vessels in the retina, the part of the eye that is sensitive to light and helps you see. When the blood vessels are weak, they can leak fluid, which causes swelling in the eye. The swelling blurs your vision. If the eye damage gets worse, your eye attempts to fix this damage by making new blood vessels over the retina. But because these blood vessels are fragile, they can break open easily and bleed into the eye. Scar tissue can then form. This may cause the retina to break away from the back of the eye, which can lead to visual impairment-even blindness.

 

Kidney damage

 

Diabetes can also damage the blood vessels in the kidney so it can’t filter out the body’s waste. High blood pressure is also associated with kidney damage. If you have diabetes and high blood pressure, it is important to keep them both under control as much as possible. The longer blood sugar levels are left uncontrolled, the greater the amount of kidney damage that can occur. If the kidney damage isn’t stopped, some individuals may progress to needing kidney transplants or dialysis machines.

 

All of these complications, however, can almost always be prevented.

 

Q. How can the complications of diabetes be prevented?

 

A. Vitamins, minerals, and herbal supplements can provide powerful tools for preventing serious complications and keeping people with diabetes healthy. The best nutritional supplement contains powerful vitamins, minerals, and herbs in a synergistic formula that can effectively lower blood sugars and provide the specialized nutrients people with diabetes need.

 

Q. Which vitamins, minerals, and herbs should be included in a nutritional supplement for people with diabetes?

 

A. The vitamins, minerals, and herbs in a diabetic formula should work synergistically and be clinically demonstrated to help prevent the known complications of diabetes. To get the best results, it is very important that the right ingredients are in the diabetic formula you buy.

 

Q. How often should I take a diabetic formula supplement?

 

A. Read the label of the diabetic formula you are considering buying. Most quality products need to be taken twice a day. Keep in mind that you will still need to take a high quality multivitamin in addition to the diabetic formula supplement. A diabetic formula is complementary. That means that it is designed to be and addition to your multivitamin routine, not a replacement.

 

Q. Could the diabetic formula lower my blood sugar level too much?

 

A. In general, too low blood sugar levels should not be a problem. A high quality diabetic formula containing synergistic vitamins, minerals and herbs, most often lowers blood sugars to normal levels. However, these vitamins, minerals, and herbs will not excessively lower blood sugar levels that are already normal.

 

Q. Do I need to continue monitoring my blood sugar when taking a diabetic formula supplement?

 

A. Diabetes is a disease that requires active participation from you. You need to be aware of your problem and be in control of it as much as possible. If you use a home glucose monitor to check your blood sugars, you may feel more comfortable by checking your levels more frequently when you first take a diabetic formula supplement. You should always follow the recommendation of your doctor or a licensed health care practitioner regarding how often you should check your blood sugar levels.

 

According to the American Diabetes Association (ADA) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (as well as most licensed health care practitioners), a good blood sugar range for most people with diabetes (before a meal) is from about 70 to 150. An ideal range is 70-120.

 

Taking a nutritional supplement formulated especially for diabetics that contain vitamins, minerals, and herbs that work synergistically in a scientifically valid formula will help you keep your blood sugars right where the ADA and NIDDK recommend.

 

Q. Can’t I just take the diabetic formula supplement and not worry about my diet?

 

A. Unfortunately, you cannot. Successful diabetes management means doing lost of positive things. First, you need to see your licensed health care practitioner often. You need to choose foods wisely and stay active to have a positive influence on your blood sugar levels and your health. And, taking a diabetic formula supplement every day can really help. However, the diabetic formula supplement is meant to be an addition to your healthy diet, not a substitute.

 

Conclusion

 

Having diabetes might make you feel overwhelmed. Restrictions on what you may and may not eat might make you feel deprived and unfairly burdened. The possibility of disease complications may make you feel anxious and scared-even angry. It is only natural to ask “Why me?” Taking control of your diabetes, instead of letting it control you, can help with these feelings. Eating wisely and exercising every day are two important ways to improve your health. And, taking a nutritional supplement formulated specifically for people with diabetes every day can give you the critical control you need to direct your health for years to come. Many healthy years to come.

 

 

 

Part I. The Stress Response

The stress reaction is a host of responses necessary for any animal to live in the world.  Commonly called the fight-or-flight reation,  we as humans often experience it in rapid heartbeat and increased breathing rate.  It comes when we exercise more vigorously than usual, or when we are suddenly and unexpectedly frightened.

We are all different.  We show a range in how strongly we experience the stress response.  Most of us are usually calm and experience the stress response when an unexpected noise frightens us to alertness, or we run to first base as fast as we can in a benefit baseball game that is not on our usual playtime schedule.  We breathe harder for a while and notice our hearts Beating faster and harder then usual, but after a while these responses all calm down, and we are again in our usual state—out or the stress response.  Others of us are very low key, and it takes a lot to disturb our physiological calm.  Still others of us are very sensitive to triggers of the stress response and go into it “at the drop of a hat” and to a greater degree than do calmer people.  For some, parts of the stress response are almost always engaged—never really calming down all the way—giving one a hyper-vigilant or anxious demeanor.

When a stress trigger occurs, the body puts out stress hormones, magnesium and calcium, among other things, into the bloodstream.  At the same time, nerve cells begin to “fire,” telling heart and muscles to “speed up. NOW!!!”  These blood, nerve and organ changes make possible the instantaneous and collective rise in the body’s heart rate, blood pressure, and other necessities for the fight-or-flight reaction.

Much research has been done on the stress response, especially on the effects of stress hormones, such as adrenaline (also called epinephrine) on body, organ and cell.  You can get an idea of how widespread the stress response is-affecting every aspect of physiology—by noting some of the reactions to adrenaline, one of the major stress hormones.  See Table 1.

Table 1 The effects of Adrenaline: Adrenaline (also called epinephrine) is one of the body’s major stress hormones.  When adrenaline is released into the bloodstream, it has simultaneous, rapid, and widespread effects on the body. These include: Widespread effects on circulation, muscles and sugar metabolism Raised heart rate Increased heart output Increased rate and depth of breathing Increased metabolic rate Increased force of muscular contraction Delayed muscular fatigue Reduced blood flow to bladder (muscular walls relax and sphincters contract) Reduced blood flow to intestines Increased blood pressure Increased sugar (glucose) in the blood Increased breakdown of glucose for energy*, especially in muscle cells Increased free fatty acids in the blood* More oxidation of fatty acids to produce energy* More ATP (the cells’ primary energy compound) produced* Blood vessels constrict   *needs magnesium

 

Much study as the cellular, biochemical and physiological levels has shown that the stress response vitally involves the influx of calcium into cells,  resulting in a drastic change in the cells’ internal magnesium-to-calcium ratio (Mg:Ca).

In simple solutions, such as salt water, all ions are evenly dispersed.  Not so in living cells.  Ions are carefully and meticulously separated in living cells, and this ion “packaging” is vital to life processes and health.  Calcium ions, for the most part, are kept outside cells while magnesium ions are kept mainly inside cells.  The stress response changes this.  During stress response, calcium ions rush inside the cell, and this alters the internal Mg:Ca ratio.  This change in ratio exhibits wide effects because, while magnesium and calcium are very similar in their chemistry, biologically these two elements function and react very differently.  Magnesium and calcium are two sides of a physiological coin: they are antagonistic to one another yet comes as a team. For example:

• Calcium excites nerves; magnesium calms them down. 
• Calcium makes muscles contract, but magnesium is necessary for muscles to relax.
• Calcium is necessary to the clotting reaction—so necessary for wound healing—but magnesium keeps the blood flowing freely and prevents abnormal thickening when clotting reactions would be dangerous.

Scientific study shows more and more that the underlying cellular change enabling the stress response is a low Mg:Ca ratio caused by a large and sudden influx of calcium into cells.  This stress response subsides when the cell’s magnesium returns to its dominant presence inside cells, moving extra calcium back outside cells to its “normal” Mg:Ca ratio.  This underlying principle is present in studies of nerve cell-stress hormone response, organs such as hearts, the high blood pressure response to stress, and the blood-clotting reaction during stress, among many others.  See Table 2.

 

Table 2 Magnesium and calcium are an “antagonistic” team in the fight-or-flight reaction.
Function	Calcium’s influence	Magnesium’s influence
Blood cell clumping (platelet aggregation)	Activates	Inhibits
Other blood-clotting reactions	Encourages	Discourages
Nerve excitation	Enhances	Discourages
Adrenaline secretion	Enhances	Decreases
Adrenaline response	Enhances	Decreases
Blood vessel contraction	Increases	Decreases

 

“During stress response, calcium ions rush inside the cell, and this alters the internal Mg:Ca ratio.  This change in ratio exhibits wide effects because, while magnesium and calcium are very similar in their chemistry, biologically these two elements function and react very differently.  Magnesium and calcium are two sides of a physiological coin: they are antagonistic to one another yet come as a team.”

 

In the normal healthy state, the stress response occurs when necessary, and subsides when the crisis or trigger is over.  Since magnesium and calcium—two essential nutrients that must be obtained by the body from its dietary environment—are so essential to this important response, it is not surprising that nutritional magnesium and calcium status can affect the response. 

 

Let’s see how.

In the normal unstressed state, cellular Mg:Ca ratio is high.  If this cannot be maintained due to lack of adequate body magnesium or an overwhelming amount of body calcium, the ratio may not be able to maintain or return itself to its healthy nonstressed ratio.  In such a case, the stress response, in the absence of an appropriate trigger, can occur.  This can be seen when nutritional magnesium deficits cause high blood pressure or increase blood stickiness (platelet aggregation). Additionally, since a low Mg:Ca ratio can increase adrenaline secretion as well as cells’ response to adrenaline, a too low magnesium state can keep the stress response from subsiding in a timely way.  Even worse, when body magnesium becomes drastically low, this becomes a stress trigger in itself, alarming the body into further stress response with out enough magnesium to back it up, resulting in a low magnesium-high stress crisis that can end in sudden death.

In the industrialized world, we live in a state of chronic, on-going stress.  This environmental reality increases our daily need for magnesium in order to maintain a healthy stress response that can calm when not necessary.

 

Part II. Heart Disease Is Often a Magnesium Deficiency

Clearly, an adequate amount of nutritional magnesium—in proper balance with adequate nutritional calcium—is key to a healthy stress response.  And yet today we have diets dangerously low in magnesium.  Add the recent additions of nutritional calcium via supplements and food fortifications meant to stave off osteoporosis, and many of us are getting inadequate magnesium plus too much calcium.  This results in a large occurrence of heart disease.

Not all, but much of the heart disease in the industrialized world can be explained by the low magnesium state of these societies.  People with heart disease—for the most part—are people who are in a state of magnesium that is borderline or deficient.  Many studies on heart disease patients exist due to medicine’s effort to understand and treat this widespread malady.  Although not intended as such, this body of research shows us what stress can do to a person in a magnesium deficient state.

 

Part III. Mental and Emotional Stress Deplete Magnesium

It is commonly accepted that certain traditional risk factors for heart disease exist.  This include high cholesterol, high blood pressure, family history of heart disease, and other factors, all of which can be linked to a shortage of nutritional magnesium.  Recent studies tell us that stresses—both sudden and chronic—with their high magnesium requirements, are also strong risk factors for heart disease.

The sudden stress of the L.A. earthquake and the 9/11 World Trade Center attack showed an upsurge of adverse heart events in people with heart disease.  Even heart patients living in Florida, hundres of miles away from the WTC attack, showed more adverse heart events in response to 9/11 than in usual times.  Again, adverse heart events in this largely magnesium deficient population show that the triggered stress response tested their magnesium status and found it wanting.

Emotional stress and phobic anxiety cause heart problems in patients with heart disease—a population we know to be mostly low in their nutritional magnesium status.  Chronic states of emotional stress, including a history of childhood abuse, neglect or family dysfunction, depression, and panic disorder, must now be added to the list of traditional risk factors for heart disease such as high blood pressure and high cholesterol.  Depression can be a symptom of low magnesium status.  So can anxiety, panic attacks, irritability, hyperactivity, and over-sensitivity to loud noises.  Do these newly found risk factors cause heart disease, or are they risk factors because the, as well as heart disease, can all be aspects of low magnesium status?  These chronic sources of stress can increase the human need for magnesium as well as be caused by its deficit.

Emotional stress triggers in susceptible people can even bring a sudden death due to heart attack, presumably by initiating a stress/low-magnesium crisis.  Such emotional “triggers” include work stress, high-pressure deadlines, social isolation and loneliness, low socioeconomic status, anxiety, war, fear of war, anger and rage.  Identical stress triggers cause more human heart attacks regardless of age, race, gender, or geographic location, including continent.

Mental stress, such as working out a math problem, can be shown to have impact upon the magnesium-stress response connection, since it can bring on heart attacks in people with heart disease.

“Recent studies tell us that stresses-both sudden and chronic—with their high magnesium requirements, are also strong risk factors for heart disease.”

 

Part IV. Stress, Magnesium and Aging

We are hearing a lot about stress in the health media, and rightly so as this constant companion to our lives brings on the fight-or-flight syndrome, a stress response that, when activated, has been shown to shorten lifespan.  When we realize that the stress response is exacerbated when we are low in magnesium, that we are living on low-magnesium foods for the most part, and that our lifestyles are more and more filled with chronic stresses and stressful events, we are not surprised to see that several aspects of magnesium deficiency are remarkably like aspects of the aging process.

When faced with out stressful lifestyles, coupled with a society presenting a chronically low-magnesium/high-calcium diet, what is our best defense? For many of us, magnesium supplements can help to preserve or restore a healthy Mg:Ca balance, so important to our health in these stressful times.