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  Messages 1-20 from 20 matching the search criteria.
Curcumin may protect the brain after a traumatic brain injury Darrell Miller 1/8/19
Bioperine: Powerful Synergistic Compound Darrell Miller 5/29/17
Bioperine Promotes Maximum Absorption Darrell Miller 2/6/12
What is Bioperine and How Does It Help with Absorption of Vitamins Darrell Miller 4/21/11
Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination Darrell Miller 3/22/10
Boost Absorption With Natural Vitamins Darrell Miller 4/17/09
Increase Absorption Of Your Discount Vitamins With Bioperine Darrell Miller 11/2/07
Benefits - Supports joint function and tissue health* Darrell Miller 12/11/06
Degenerative joint disease (osteoarthritis) Darrell Miller 8/24/06
High Absorption CoQ10 Darrell Miller 2/13/06
Naturally enhanced powers Darrell Miller 2/10/06
Goes above and beyond antioxidant protection. Darrell Miller 2/10/06
Benefits of Total Daily Formula Darrell Miller 10/13/05
Re: Magnesium Darrell Miller 10/6/05
Curcumin - Turmeric Extract Darrell Miller 8/19/05
Gentle Giant Glycinate - Calcium / Magnesium Glycinate 1:1 ratio Darrell Miller 7/11/05
Digest Active - For Occasional Indigestion Darrell Miller 6/29/05
Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort Darrell Miller 6/2/05
COENZYME Q10 - Transforming food into energy Darrell Miller 6/1/05
Immunomodulating and anti-tumor action of extracts of several mushrooms Darrell Miller 5/18/05



SOURCE NATURALS AHCC Complex w Bioperine
   60 caps $119.98 29% OFF $ 85.19
SOURCE NATURALS AHCC Complex w Bioperine
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Doctors Best Best Curcumin C3 Complex with Bioperine
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Natures Plus BIOPERINE 10 MG
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Natures Plus BIOPERINE 60
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SOURCE NATURALS Bioperine Black Pepper Fruit Extract 10 mg
   60 tabs $6.50 29% OFF $ 4.62
SOURCE NATURALS Bioperine Black Pepper Fruit Extract 10 mg
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SOURCE NATURALS Coenzyme Q10 With Bioperine 100 mg
   30 SG $9.50 29% OFF $ 6.74
SOURCE NATURALS Coenzyme Q10 With Bioperine 100 mg
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SOURCE NATURALS Coenzyme Q10 With Bioperine 100 mg
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SOURCE NATURALS Coenzyme Q10 With Bioperine 30 mg
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SOURCE NATURALS Coenzyme Q10 With Bioperine 30 mg
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SOURCE NATURALS Coenzyme Q10 With Bioperine 30 mg
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HEALTH THRU NUTRITION CoQ-10 w/ BioPerine® 100mg NON-GMO
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Doctors Best CoQ10 plus PQQ with BioPerine
   60 Veggie Caps $58.33 45% OFF $ 32.08
Natures Plus DHEA-10 With BIOPERINE 10MG 90
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Natures Plus DHEA-10 With BIOPERINE 10MG VCAPS 90 (4967)
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Natures Plus DHEA-25 With BIOPERINE 25MG 60
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Doctors Best High Absorption CoQ10 100mg with Bioperine
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Doctors Best High Absorption CoQ10 with BioPerine (200 mg)
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Doctors Best High Absorption CoQ10 with BioPerine (600 mg)
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Doctors Best High Absorption CoQ10 with BioPerine® (200 mg)
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Zhou Nutrition Turmeric Curcumin w/ Bioperine 1650mg
   Veg Cap (Btl-Plastic) 90ct $26.99 33% OFF $ 18.08

Curcumin may protect the brain after a traumatic brain injury
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Date: January 08, 2019 08:13 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin may protect the brain after a traumatic brain injury





Oxidative neurodegeneration is a process in which oxidative stress results in degeneration of the brain, often related to a traumatic brain injury (TBI). Studies are now showing that curcumin has protective abilities that can help decrease the brain's vulnerability to further injury as a result of oxidative stress. This could be due to several factors such as its anti-inflammatory properties, the way it increases antioxidants, and its natural healing properties that can aid in regeneration.

Key Takeaways:

  • Shockingly, traumatic brain injuries (TBI) affects several people in America. It is reported that they are sustained by about 2.8 million Americans every year.
  • It has been calculated that traumatic brain injury, TBI, is a cause of all injury-related deaths in America by about 30 percent.
  • Treatment for TBI which can include anything sufficient strong to cause brain injury to the head can include pain relief for mild cases, and ensuring adequate brain oxygen.

"When choosing a curcumin supplement, it is important to source one that is non-GMO, non-irradiated and preferably contains piperine (Bioperine) which enhances curcumin absorption by as much as 2,000 percent"

Read more: https://www.naturalnews.com/2018-12-26-curcumin-may-protect-the-brain-after-a-traumatic-brain-injury.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5940)


Bioperine: Powerful Synergistic Compound
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Date: May 29, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Bioperine: Powerful Synergistic Compound





Bioperine is an extract found in many pepper plants. It is related to the turmeric family. It has been tested in animals to possibly lower cancer rates in humans. It can also possibly boost your metabolism and encourage weight loss. It is easier to introduce in the market as a food rather than a pharmaceutical supplement. The product can also warm internal body levels and improve digestion which helps your body absorb more nutrients. Bioperine is a relatively safe product.

Key Takeaways:

  • standardized ingredients are important for supplements so that you receive the same results with each use.
  • Piperine has been shown to reduce weight by 20% and have strong anti-cancer actions in animal studies.
  • Adherence to quality is the most important quality to look for in a supplement because under the FDA's guidelines, one could simply use table pepper and sell it as piperine extract.

"This novel compound is one of several bio-active alkaloids found in these plants, and offers a slew of remarkable health benefits"

Read more: https://www.organicnewsroom.com/bioperine/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4724)


Bioperine Promotes Maximum Absorption
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Date: February 06, 2012 06:19 PM
Author: Darrell Miller (support@vitanet.net)
Subject: Bioperine Promotes Maximum Absorption

Bioperine

Bioperine is an extract from black pepper that contains about 95 percent piperine. Piperine is an alkaloid, the active substance that contributes to nutrients bioavailability and absorption. Bioperine can be combined with other specific nutrients to form different nutritional supplements that can be used for both animal and human consumption. Black pepper is mostly harvested before ripening, dried in the sun and then the extraction process begins.

How and why use of Bioperine promotes maximum vitamin absorption

Recent research has shown that the use of Bioperine, whose main constituent is piperine, increases thermogenic activity in the body. Thermogenesis is an accelerated metabolic process that takes place in the body cells in which conversion of glucose into energy takes place. An increase in absorption of discount minerals such as selenium and vitamins such as vitamin A has been witnessed to be triggered by the use of Bioperine. Piperine works through initiating the release of catecholamines hormones that stimulate thermogenesis. However, the nutrients should presently available during this time since; the process takes place for a short duration.

Piperine improves the necessary conditions of the intestines thus enhancing vitamins absorption. It alters the intestinal epithelial cell wall making it more permeable to vitamins and minerals. In addition, absorption of protein supplements such as those used by people who are on a dietary weight loss program is also increased. Several researchers have also shown that Bioperine has other benefits in the body, these includes the antibacterial properties and anti allergy properties.

Experiments prove that use of Bioperine increases vitamin and mineral absorption

Several studies on how much piperine promotes nutrients absorption have been carried out hitherto. For instance, an experiment was carried out on the effect of absorption of beta-carotene, vitamin B-6 and selenium which are fat soluble vitamin, water soluble vitamin and mineral in the form of selenomethionine respectively in the presence and absence of piperine. The experiment showed that absorption of these vitamins and mineral selenium increased appreciably when taken with Bioperine. There was 60 percent increase in absorption of beta-carotene and vitamin B-6 while 30 percent absorption was noticed for selenium. The experiment was carried out using 5 milligrams of Bioperine. Another experiment also showed a 30 to 200 percent increase in the absorption of Coenzyme Q-10.

Bioperine is the only piperine product to undergo comprehensive health tests and to be patented for the effect of increasing nutrients absorption, more so vitamins and minerals. By creating metabolic changes that require vitamins and minerals, Bioperine creates a nutritional need and then follows by increasing the nutrients bioavailability to meet the need. However, the process takes place in a short period. It is therefore advisable to co-administer minerals and vitamins with Bioperine so that they will be available during the right time for absorption. Unfortunately, research has shown that taking black pepper in its natural form does not yield the same results as those of taking Bioperine. This is mainly because the bioavailability of piperine is not that high in the natural form. Finally, antibacterial and anti allergy properties of Bioperine diversifies its application in medication.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2557)


What is Bioperine and How Does It Help with Absorption of Vitamins
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Date: April 21, 2011 03:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Bioperine and How Does It Help with Absorption of Vitamins

Get more from your food with Bioperine.

Bioperine is a patented form of an alkaloid found in black pepper. It is derived entirely from piperine, an organic compound responsible for the spicy taste of black pepper and long pepper. Piperine has been noted for its thermogenic properties believed to speed up the absorption metabolism of digested foods. Recent studies have discovered that it also interferes with the release of enzymes that govern the bioavailability of drugs and supplements. By so doing, it enhances the rate of absorption of vitamins.

The human body has a complex mechanism of controlling the substances that get in and out of systemic circulation. The first pass occurs in the alimentary canal, where gastrointestinal enzymes break down substances into smaller compounds. It is believed that a very small percentage manages to undergo intestinal absorption after digestion. In general, this is the part where constituents of supplements remain undigested and instead enter the colon together with waste materials.

The liver plays a central role to the metabolism of drugs and most bioactive compounds. The compounds that pass the intestinal walls and enter the hepatic portal system, a group of veins that direct blood and other compounds from the gastrointestinal tract to the liver, is further metabolized inside the liver. Anything that the body considers foreign is sent to the kidneys and easily excreted through the urine. This is the reason why bioavailability is significantly reduced after ingestion.

Counteracts Effects of Enzymes

Bioperine is the only compound known to interact with enzymes that controls the metabolism of foreign materials within the intestinal epithelium. P-glycoprotein is released in the digestive tract to deal with drugs and xenobiotics found in our diet. Vitamins are no exception to the tightly regulated process of absorption in the intestines. These enzymes transport digested compounds to the liver.

It has been observed that piperine appears to reduce the expression of p-glycoprotein in the alimentary canal and other parts of the body. Proponents believe that Bioperine, a purer form of piperine, is capable of counteracting the effects of the enzyme within the intestinal epithelium, making it easier for vitamins and supplements to enter the hepatic portal system.

Increases the Rate of Metabolism

Not all compounds that undergo the first-pass effect interact with the cells and tissues they are supposed to act on. If they should have an effect on any cell, they are still subjected to the actions of enzymes specialized for the expulsion of xenobiotics found in the systemic circulation and the rest of the body. For example, CYP3A4 removes foreign materials from the cells and facilitates their excretion.

Bioperine is touted to induce thermogenesis and stimulate cellular activities. By so doing, the effects of bioactive compounds are achieved while they remain inside the cells and tissues. The thermogenic properties of Bioperine influence the rate of metabolism of digested compounds, including vitamins, minerals, and components of herbal preparations. Note that it can increase the update or prescription medications as well, so caution should be observed when consuming Bioperine with medications.

If you want to give your body a nutrient boost, add Bioperine to your supplement regiment to boost absorption.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2280)


Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination
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Date: March 22, 2010 09:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination

turmeric root sample for articleTurmeric / Boswellia Complex

Our modern lives have untold benefits, as well as great challenges. Our dependence on man-made toxic chemicals, junk food, nutrient-imbalanced diets, and our stressful, sedentary lifestyles can alter our biochemical metabolism and affect our health. These unhealthy lifestyles and environmental changes have set our immune system on overdrive, a state call metabolic inflammation. Planetary Herbals Inflama-Care is a potent, herbal response to these modern challenges.

The Inflammation Cycle

As toxins and stress begin to alter our body chemistry and change the function of vital tissues, our body reacts with metabolic inflammation just as if it were being attacked. This reaction may result in a perpetual cycle of chemical imbalances and suboptimal health. Yet metabolic inflammation is often below the threshold of perception, not noticed or felt for years after its starts. It is only much later that the altered biochemistry and the system imbalances that it generates are noticed.

A Powerful Herbal Blend boswellia sample for article Inflama-Care helps support the body’s natural response to metabolic inflammation. The main component of the formula is the rhizome of the curcuma species, long used as a spice in India. Known worldwide as turmeric (Curcuma longa), it acts as an anti-inflammatory by inhibiting the activities of cytokines—inflammation messengers. This world-renowned spice is supported by boswellia, which inhibits proinflammatory enzymes, and ginger, an antioxidant that inhibits prostaglandin and leukotriene biosynthesis. Other herbs in the formula that inhibit inflammatory action include willow bark, Chinese skull cap, corydalis, holy basil, and hops.

The PhytoDynamic Difference

Planetary Herbals presents inflama-Care to help maintain the body’s biochemical balance and integrity. Inflama-care was formulated with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. Thie result: herbal products unsurpassed for quality and consumer satisfaction.
Inflama-Care 60 tabs from PLANETARY HERBALS

Amount %DV
Calories 5
Calcium (naturally occurring and dibasic calcium phosphate) 57 mg 6%
Sodium (naturally occurring) 5 mg <1%
Turmeric Rhizome Extract (95% curcumin) 900 mg
Boswellia serrata Gum Resin Extract (85% boswellic acid) 400 mg
Ginger Root Extract (5% gingerol) 250 mg
Willow Bark Extract (15% salicin) 100 mg
Chinese Skullcap Root Ext. (30% flavones) 100 mg
Bromelain 100 mg
Papain 100 mg
Hops Flower Extract (Perluxan™) yielding 30 mg Humulex™ alpha-acids 50 mg
Corydalis yanhusuo Tuber 50 mg
Holy Basil Leaf Extract (2% ursolic acid) 50 mg
Quercetin 50 mg
Rosemary Leaf Extract (20% diterpenes) 50 mg
trans-Resveratrols (from Polygonum cuspidatum root extract) 25 mg
Masson Pine Bark Ext. (95% procyanidolic value) 25 mg
Grape Seed Extract (95% procyanidins) 25 mg
EGCG (epigallocatechin gallate) (from decaffeinated green tea leaf extract) 25 mg
Lecithin 25 mg
Black Pepper Fruit Extract (Bioperine®) 5 mg

~video~

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Boost Absorption With Natural Vitamins
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Date: April 17, 2009 11:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Boost Absorption With Natural Vitamins

Malabsorption occurs when the body fails to properly absorb vitamins, minerals, and other nutrients from food. Even though a person’s diet is adequate, an individual with malabsorption develops various nutritional deficiencies. This problem is often the result of impaired digestion, impaired absorption of nutrients into the bloodstream from the digestive tract, or both.

Common symptoms of malabsorption syndrome include constipation or diarrhea, dry skin, fatigue, gas, mental difficulties such as depression or an inability to concentrate, muscle cramps and/or weakness, premenstrual syndrome, steatorrhea, a tendency to bruise easily, failure to grow normally, thinning hair, unexplained weight loss, and visual difficulties especially with night vision. Abdominal comfort may also be present and a combination of anemia, diarrhea, and weight loss is typical. However, in some individuals, obesity may result if fats are deposited in the tissues rather than being utilized properly by the body. Additionally, the body may begin to crave more and more food, which often leads to the consumption of many empty and/or fat calories.

Factors that can contribute to a malfunction of the absorption mechanism include digestive problems, poor diet, excess mucus covering the intestinal lining, an imbalance in intestinal bacterial flora, the use of certain medications, food allergies, and illnesses such as cancer and AIDS.

No matter how good your diet is or how many supplements you take, you will have nutritional deficiencies if you suffer from malabsorption syndrome. These deficiencies lead to other problems. The impaired absorption of protein can cause edema, while a lack of potassium can cause muscle weakness and cardiovascular problems. Anemia results for a lack of iron and folic acid, while bone loss and tetany can be caused by a lack of calcium and vitamin D. Bruising easily results from a lack of vitamin K, while night blindness comes from a deficiency of vitamin A. The failure to absorb B vitamins and to transfer amino acids across the intestinal lining interferes with the production of needed digestive enzymes and causes further malabsorption, as these nutrients are essential in the absorption process itself. This causes a vicious cycle to be produced.

Malabsorption is a factor in other medical and physical problems, along with being a serious condition in itself. The body needs all nutrients in balance because they have to be able to work together. If there is a deficiency in even a single nutrient, the body no longer functions as it should, allowing all things to go awry. This results in disease. Malabsorption is a common contributing factor to a wide range of disorders, including cancer, heart disease, osteoporosis, and all types of infection.

People with malabsorption syndrome must take in more nutrients than the average person to compensate, and to treat and correct the problem. It is best to bypass the intestinal tract as much as possible when supplying these nutrients. As a result, choosing supplements that are sustained-release and large in size should be avoided. Many people with malabsorption problems can not break down supplements taken in hard pill form. Therefore, injections, powders, liquids, and lozenges provide nutrients in forms that are more easily assimilated.

The following nutrients are recommended for dealing with malabsorption syndrome: acidophilus, vitamin B complex, Bioperine, calcium, free-form amino acid complex, garlic, magnesium, vitamin C with bioflavonoids, vitamin E, essential fatty acids, a multi-vitamin and mineral complex, proteolytic enzymes, and zinc lozenges. Additionally, the following herbs may be beneficial: alfalfa, dandelion root, fennel seed, ginger, nettle, aloe vera, peppermint, black pepper, buchu, goldenseal, irish moss, rhubarb, and yellow dock.



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Buy Natural Vitamins at Vitanet ®, LLC

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Increase Absorption Of Your Discount Vitamins With Bioperine
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Date: November 02, 2007 04:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Increase Absorption Of Your Discount Vitamins With Bioperine

In order to understand how you increase absorption of your discount vitamins with Bioperine, it is necessary to understand the metabolic process of thermogenesis. First, however, let’s have a look at what Bioperine is and where it comes from.

Bioperine is obtained from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) of which it is a patented standardized extract. These peppers contain the alkaloid piperine, and the extract contains 95% piperine. The plants are grown in the ideal damp soil in regions of Southern India where the earth is rich in nutrients. The barriers are harvested just before ripening, and then dried in the hot sun before the extraction process is started. Piperine has many uses from flavoring to fly killer, but people have been using it for centuries to heal wounds though this is apparently unconnected with the use to which the extract is put.

It has recently been found to help increase the absorption of a number of discount vitamins and minerals, including Vitamin B, beta-carotene, and selenium, by increasing the thermogenic activity of the body. Thermogenesis is one of the metabolic processes of the body that takes place within our cells whereby glucose is converted to energy, but at an accelerated metabolic rate. It is the rise in the metabolic rate that is referred to as thermogenesis.

When you eat food, or take supplements, the metabolism increases above the normal rate, the amount of increase depending upon the type on nutrient taken. Fats will increase your metabolism at a lower rate than proteins will, for example, since more energy is needed to break down proteins than for fats. Another substance that stimulates thermogenesis is piperine. It does so by utilizing the biochemistry of the body so that the chemicals needed for thermogenesis are made available.

Piperine triggers the release of compounds known as catecholamines, hormones that in turn stimulate the thermogenetic process. However, this occurs over a short period of time, so the nutrients that are needed should be present in the gut as well since the window of absorption is very narrow. The substance also modifies the epithelial cell wall of the intestine to make it easier for the nutrients to be absorbed into the bloodstream, and it also gives amino acids a kick to get moving to the cells in which they are required.

Bioperine, then, not only sets off the metabolic changes that demand vitamins and other nutrients and enzymes, but also improves the conditions in your intestines so that these nutrients can more easily get to where they are needed. Basically, what Bioperine does is to cause the intestinal wall to become more permeable to nutrients, so that vitamins and drugs are not degraded when passing through the intestinal wall to the bloodstream. This improves digestion and absorption of minerals and vitamins, in addition to protein supplements frequently used in weight loss diets.

Bioperine starts by generating a need for nutrition and then increase the bioavailability of the nutrients provided to meet that need. However, due to the short window of absorption that piperine generates, the vitamins and minerals you want absorbed should be co-administered with the Bioperine so that they are in place ready to be absorbed at exactly the right time.

There have been several studies carried on the efficiency with which piperine achieves this. The absorption of three different types of nutrients has been measured with and without Bioperine. These were beta-carotene, a fat soluble vitamin, vitamin B-6, a water soluble vitamin, and also a mineral, selenium which was provided as selenomethionine. The absorption of these by the digestive system was measured by detecting them before and after in the blood, and were found to increase considerably when taken along with Bioperine, but not so with the control group without it.

Measured increases were a 60% increase in beta-carotene, similar to that of vitamin B-6, and was 30% in selenium. The tests used a 5 mg dose of the Bioperine. Other studies have indicated an increase in the absorption of Coenzyme Q-10 of between 30% - 200%. This is the only piperine based product that has been patented for its effect in increasing the absorption of nutrients into the body, and also the only piperine based product to undergo such tests in the U.S. to substantiate its claims and prove its safety for use.

The black pepper itself is a common household spice, and has been used in India for its medicinal properties for centuries. It is mentioned in the practice of Ayurveda and its concentration on the function of the digestive tract in human health. Many of its formulas contain black pepper amongst their ingredients. The bioavailability of nutrients is a significant factor in the health of any specific population, and the exponents of Ayurveda overcame this problem, by chance or design, six millennia ago. It has been demonstrated time and time again that diet is not the factor of importance in nutrition, but how much of that diet is absorbed through the intestines.

This is yet another example of the medicines of our ancestors being shown to have a solid scientific basis, and perhaps we should pay more attention to those others that are disregarded by modern science. It could be that we have only scratched the surface of understanding human metabolism and biochemistry, and that there is much left to learn. Ancient wisdom should never be disregarded.

Bioperine is also available in many supplement mixtures so that it is taken at the same time as the relevant vitamins and minerals. The recommended dosage is from 1 mg – 5 mg from 2 – 3 times daily. It takes around 2 – 5 mg of Bioperine to provide sufficient enhancement of absorption of the nutrients that are taken with it. Keep in mind that the nutrients are best taken at the same time, and that taking the extract itself will simple increase the absorption of any nutrients that are in the intestine at that time. Bioperine can be purchased at your local or internet vitamin store.



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Bioperine Black Pepper Fruit Extract

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Benefits - Supports joint function and tissue health*
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Date: December 11, 2006 03:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits - Supports joint function and tissue health*

To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.

Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3

Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3

Promotes optimal joint comfort, function and flexibility*

Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4

Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7

Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8

Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11

Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.

Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*

Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14

Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.

Sustained Release – For lasting joint comfort and convenient dosing

To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.

Safety

Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.

Scientific References
1. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L. Articular cartilage pharmacology: I. In vitro studies on glucosamine and non-steroidal antiinflammatory drugs. Pharmacological Research Communications 1978; 10(6):557-569.

2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.

3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.

4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.

5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.

6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.

7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.

8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.

9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.

10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.

11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.

12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.

13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.

14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.

15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.



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Degenerative joint disease (osteoarthritis)
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Date: August 24, 2006 03:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Degenerative joint disease (osteoarthritis)

Degenerative joint disease (osteoarthritis) damages or destroys cartilage and its supportive collagen structure. As many as 40 million Americans, including the majority of people over age fifty, are thought to suffer from some form of this disease. Primary osteoarthritis, the “wear and tear” form, is due to normal use and age-related causes. Secondary osteoarthritis results from repeated joint trauma, inherited predisposition, or previous inflammatory conditions. While non-steroidal anti-inflammatory drugs (NSAIDs) treat symptoms only, a natural, holistic approach strives to improve the environment of the cartilage and joint as a whole by providing protective and restorative nourishment, increased circulation, decreased inflammation and reduced free radical damage.

High levels of Glucosamine and Chondroitin Sulfate

Widely regarded as the first defense in protecting joints, glucosamine and Chondroitin sulfate have been shown to effectively control joint pain and slow down or reverse the progression of cartilage deterioration. The integrity of joint gliding surfaces as well as the health of tendons, ligaments, joint fluids, skin, bones, heart valves and virtually all structural elements in the body is dependent upon the proper synthesis and availability of proteoglycans, integral components of joint cartilage.

Glucosamine provides two components critical to the synthesis of proteoglycans: hyaluronic acid and glycosaminoglycans (GAGs).

Chondroitin sulfate represents an important group of GAGs. It is not a single compound, but rather a class of compounds with different molecular weights that each have specialized functions within the body.

Numerous studies have shown that long-term safety, reduction in pain and protection of cartilage with body chondroitin and glucosamine are comparable or superior to results obtained with NSAIDs.

MSM. (Methylsulfonylmethane) MSM is a rich source of sulfur, a mineral required for GAG synthesis. A preliminary study suggests that MSM may help reduce pain in persons with degenerative arthritis.

Gota Kola. (Centella asiatica) known to support collagen synthesis and stimulate GAG’s, Gota Kola has been used for many years in Europe to promote wound healing and blood vessel integrity. It also has been shown to improve circulation in small vessels.

Turmeric. (Curcuma longa) this saffron-colored root offers a wide range of benefits. It naturally inhibits the inflammatory COX-2 enzyme, reduces pain and is a potent antioxidant that protects the liver and other cells. High antioxidant diets may inhibit joint deterioration.

Bromelain. Derived from pineapple cores, Bromelain is most commonly used for healing soft tissue injuries and inflammation. It contains potent selective proteases (protein-digesting enzymes) and other substances which serve to block destruction of GAGs.

Trace Minerals. Micronutrients play many distinct roles in support of healthy joint connective tissue and joint cartilage matrix.

Black Pepper Extract. Bioperine is a highly concentrated extract (95% - 98% piperine) of black pepper. Used as a bioavailability enhancer, it has been shown to increase the absorption of vitamins, minerals and herbs.



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High Absorption CoQ10
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Date: February 13, 2006 05:42 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: High Absorption CoQ10

The human heart beats more than two and a half billion times in an average lifetime. The energy required for this miracle of nature is enormous, and maintaining heart tissue energy levels is essential. A vitamin-like nutrient found in the human body, Coenzyme Q10 or CoQ10 supports heart function. Without adequate CoQ10, cells become energy-deficient. When nourished with optimal levels of CoQ10, your body tissues, including the liver, nerves and muscles function optimally. With its high energy requirements, the heart needs to be supplied with CoQ10 at all times. Numerous clinical studies have shown significant improvements in heart function with oral administration of CoQ10. Immune cells need large amounts of energy, and CoQ10 helps make it available. A versatile antioxidant, it stabilizes membranes and protects them from free-radical damage. A fat-soluble nutrient, CoQ10 is difficult to absorb, so we’ve added Bioperine. Preliminary Trails on humans have shown significant increases in absorption of Bioperine-enhanced nutrients. High absorption CoQ10, a pharmaceutical grade supplement, is now available in three different forms: 30mg/60 caps; 100mg/30 caps; and 100mg/60 caps. High Absorption CoQ10 with Bioperine


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Naturally enhanced powers
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Date: February 10, 2006 06:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Naturally enhanced powers

Curcumin is poorly absorbed in the GI tract, which limits its effectiveness. Fortunately, nature has an answer, in the form of piperine, a component of black pepper. Piperine has been shown to increase Curcumin absorption by as much as 2000% when the two are consumed together. For this reason Doctors best has combined Curcumin with Bioperine, a patented black pepper extract that supplies 95%-98% piperine.

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Goes above and beyond antioxidant protection.
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Date: February 10, 2006 06:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Goes above and beyond antioxidant protection.

Antioxidants abound in the plant kingdom. Modern science has discovered that Turmeric (Cucuma Longa) contains a family of compounds called “curcuminoids.” Known collectively as “Curcumin”, these natural plant substances are powerful antioxidants – and much more. Best Curcumin with Bioperine contains Curcumin C3 Complex, a special extract of curcuma longa, and each capsule provides 500mg.

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Benefits of Total Daily Formula
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Date: October 13, 2005 04:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Total Daily Formula

Benefits of Total Daily Formula

Mixed Carotenoids

All fruits and vegetables contain carotenes, the plant pigments responsible for the rich variety of colors we enjoy in the natural world. Beta carotene is the most familiar member of the carotene family. But beta carotene never exists by itself; it is always found with other carotenes in foods. We need more than just beta carotene alone. Carotenes are powerful antioxidants, which means they help reduce the body's free radical burden. Research suggests that carotenes work as a team to keep us healthy.5 Total Daily Formula provides beta carotene, alpha carotene, lutein, lycopene, zeaxanthin and cryptoxanthin from natural sources such as algal extracts, carrot oil, marigold and tomatoes (Caromix®).

Corn-Free Vitamin C

Total Daily Formula uses only corn-free vitamin C (ascorbic acid). The full daily intake of 6 tablets provides an exceptionally generous 800 mg of vitamin C.

Optimum B Vitamin Servings

Total Daily Formula supplies ample amounts of all essential B vitamins. Vitamin B3 is given as niacin plus an extra helping of niacinamide, the non-flush form of this important vitamin. The body uses pantothenic acid (vitamin B5) to deal with stress, so the formula provides 150 mg, which is 15 times the RDA. Vitamin B6 is another B vitamin people may run short of, so 60 mg -- 30 times the RDA -- is supplied. The formula contains 800 mcg of folic acid, the vitamin now recognized by the FDA as essential for prevention of neural tube defects in unborn babies. Folic acid also helps prevent accumulation in the body of homocysteine, a metabolite of the amino acid methionine.6 A high blood homocysteine level is now considered to be a risk factor for heart disease.7

Flavonoids

Flavonoids, also known as "bioflavonoids." are plant pigments widely distributed throughout the plant kingdom.8 Previously known as "Vitamin P," because they help reduce capillary permeability (leakiness) flavonoids are now regarded as "semi-essential" non-vitamin nutrients that benefit health in a variety of ways.9 In addition to maintaining the structure of blood vessels, flavonoids function as versatile antioxidants. Flavonoids protect vitamin C from destruction by free-radicals, helping to preserve the body's vitamin C supply.10 Total Daily Formula provides 100 mg of pure flavonoids from 112 mg of citrus extract.

Three superior sources of Calcium

Total Daily Formula contains three of the best absorbed and most effective forms of calcium available. MCHC (microcrystalline hydroxyapatite concentrate) is a naturally-derived compound composed of calcium, plus all the minerals and organic factors in living bone tissue. MCHC has been clinically shown to benefit bone health.11 Calcium citrate malate is a very well-absorbed form of supplemental calcium shown in recent research to be helpful for postmenopausal women.12,13 Calcium glycinate is chelated with the amino acid glycine, one of the most efficient mineral carriers for effective absorption.14,15

Magnesium glycinate

Magnesium is essential for strong bones and healthy hearts. This versatile mineral also regulates nerve function, keeps muscles relaxed and coordinates activity of over 300 enzymes in the body.16 Total Daily Formula contains 100 percent magnesium glycinate for exceptional absorption and gentleness on the intestinal tract.17 Magnesium glycinate has been clinically tested on people with severe malabsorption with excellent results.18

Trace Minerals

Total Daily Formula provides - in addition to zinc, chromium, selenium and iodine - vanadium and molybdenum. Vanadium helps maintain normal blood sugar.19 Molybdenum works as a co-factor for enzymes that help detoxify and eliminate foreign substances from the body.20

Bioperine® for Enhanced Absorption

Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. 21 Betaine HCL - supplies HCL (hydrochloric acid) to assist digestion. All natural tablet coating made of vegetable concentrate and beta carotene.

Scientific References
1. Cheraskin, E. Ringsdorf, W.M., Clark, J.W. 1968. Diet and Disease. (p. 16). New Canaan, CT: Keats Publishing.

2. Morgan, K.J. et. al. Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition. 1985;4:195-206.

3. Lakschmanan, F.L., Rao, R.B., Kim, W.W., Kelsay, J.L. Magnesium intakes, balances and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 1984;40:1380-89.

4. Mertz, W. The Essential Trace Elements. Fed. Proc. 1970;29:1482.

5. Perry, G. Byers, T. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu. Rev. Nutr. 1992;12:139-59.

6. Landgren, F., et. al. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Int Med 1995;237:381-88.

7. Clarke, R., et. al. Hyperhomocysteinemia: an independent risk factor for vascular disease. New Eng J Med 1991;324:1149-55. 8. Havsteen, B. Flavonoids, a class of natural compounds of high pharmacological potency. Biochemical Pharmacology 32(7):1141-48.

9. Middleton, E. The flavonoids. TIPS 1984; 5:335-38.

10. Roger, C.R. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 44(9):725-804.

11. Dixon, A. St. J. Non-hormonal treatment of osteoporosis. British Medical Journal 1983;286(6370):999-1000.

12. Smith, K.T. et. al. Calcium Absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351-352.

13. Dawson-Hughes, B. et. al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New England Journal of Medicine 1990 Sep 27;323(13):878-883.

14. Albion Research Notes Vol. 4, No. 1, ©Albion Laboratories Jan,1995.

15. Ashmead, H.D. Intestinal Absorption of Metal Ions and Chelate, Springfield: Charles C Thomas, ©1985.

16. Wester, P.O., Dyckner, T. The importance of the magnesium ion. Magnesium deficiency-symptomatology and occurrence. Acta Med Scand 1992; (Suppl) 661:3-4.

17. Albion Research Notes Vol. 3, No. 1, ©Albion Laboratories, Feb 1994.

18. Schutte, S., et. al. Bioavailability of Mg diglycinate vs MgO in patients with ileal resections. Abstract 115, AJCN 1992;56(4).

19. Cohen, N. et. al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J. Clin Invest 1995; 95:2501-09.

20. Sardesi, V.M. Molybdenum: An essential trace mineral element. Nutr Clin Pract 1993; 8:277-81.

21. Bioperine® - Nature's Bioavailability Enhancing Thermo-nutrient. Executive Summary' 1996; Sabinsa Corporation, Piscataway, N.J.



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TopPreviousNext

Date: October 06, 2005 10:08 PM
Author: Darrell Miller (dm@vitanetonline.com)

Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance [1].

Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium [2]. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake [3]. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.

An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" [4]. The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups [5]. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium [6].

In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body [7]. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys [8].

Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium [9]. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.

Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 [10]. The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.

Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.

Magnesium-the Versatile Mineral

The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."

Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP [11]. ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".

Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles [12].

Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat [13]. Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress [14]. This has been found true even in the absence of an actual magnesium deficit in the body.

Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density [15]. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men [16]. In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency [17]. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.

Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes [18].

A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.

Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption [19]. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide [20].

Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 [21].

Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® [22].

Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Curcumin - Turmeric Extract
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Date: August 19, 2005 12:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin - Turmeric Extract

Curcumin

Turmeric- History and Traditional Usage

Native to Southeast Asia, Curcuma longa is a tall
tropical shrub with large oblong leaves and pale yellow flowers.
The genus “Curcuma” belongs to the Zingiberaceae family, which
includes ginger.1 The plant possesses a large root structure
with fleshy, bulbous underground parts called “rhizomes.” These
rhizomes, known as turmeric root, are harvested at maturity,
dried and cured for commercial use. Chemical analysis shows that
dried turmeric contains essential and volatile oils, with a
curcuminoid content of 2.5 to 5.0 %.2

In addition to its
popularity as a spice, turmeric is used as a dye for cloth and
coloring agent in foods and cosmetics, thanks to its rich yellow
color. Turmeric also serves as a preservative, probably owing to
the antioxidant and antimicrobial properties of curcumin.
Extracts of Curcuma longa have demonstrated in vitro
antibacterial and anti-fungal effects.3

Turmeric is named in
ancient Ayurvedic and Chinese herbal texts as a traditional folk
remedy. Historically, turmeric was used externally for wounds,
and sprains, and internally for digestive complaints,
rheumatism, liver disorders, coughs and colds.4
Benefits

Protects cells and tissues by fighting free radicals.*

Supports joint function*

The numerous beneficial
effects attributed to turmeric stem in large measure from the
antioxidant properties of curcumin. Antioxidants neutralize free
radicals, which are highly unstable molecules that can damage
cellular structures through abnormal oxidative reactions.
Curcumin is a potent “scavenger” of the superoxide radical, a
free radical that initiates potentially harmful oxidative
processes such as lipid peroxidation.5 Through this activity,
curcumin has been shown to protect skin cells from the injurious
effect of nitroblue tetrazolium, a toxin that generates
superoxide radicals. Curcumin also increases survival of cells
exposed in vitro to the enzyme hypoxanthine/xanthine oxidase,
which stimulates superoxide and hydrogen peroxide production.
Curcumin itself is not toxic to cells, even at high
concentrations. Pure curcumin was shown to be less protective
than a mixture of curcuminoids, indicating a possible synergism
among curcuminoids.6 Because free radicals are involved in aging
and exert harmful effects on skin, these results suggest
curcumin may help slow skin aging.

Curcumin demonstrates
several other in vitro effects linked to free radical
scavenging. Curcumin scavenges nitric oxide, a compound
associated with the body’s inflammatory response.7 Pure curcumin
and turmeric extracts protect red blood cells from lipid
peroxidation induced by hydrogen peroxide.8 Curcumin has been
shown to protect DNA from oxidative damage, inhibit binding of
toxic metabolites to DNA, and reduce DNA mutations in the Ames’
test.9 Although additional studies suggest an anticarcinogenic
effect of curcumin, through protection of DNA,10 one in vitro
study found that curcumin induced DNA damage in human gastric
mucosal cells.11 It is speculated that curcumin may act as a
pro-oxidant in the presence of transition metal ions such as
copper and iron. (This is true for other antioxidants, including
vitamin C.) Curcumin also demonstrates in vitro inhibition of
COX-I and COX-II enzymes, which are involved in the inflammatory
reaction.12 Together these results strongly suggest that
curcumin is a potent bioprotectant with a potentially wide range
of therapeutic applications.

Animal studies- In vivo protective effects

Through its free radical scavenging
properties, curcumin has shown bioprotective effects in animals.
In one study, rats were treated with isoproterenol, a chemical
that causes cardiac hypertrophy (enlargement of the heart) due
to abnormal collagen metabolism. Co-treatment with curcumin
reversed the degradation of collagen and cardiac hypertrophy
induced by isoproterenol.13 Curcumin protects mice from
detrimental effects of radiation, by stabilizing the glyoxalase
system, a biological system that regulates cell division.14
Curcumin protects livers of rats from the damaging effects of
carbon tetrachloride (CCl4), a potent hepatoxin that injures the
liver via its free radical metabolite, CCl3.15,16 Curcumin
protected rats from alcohol-induced brain damage, in a study in
which oral administration of curcumin reversed lipid
peroxidation, reduced levels of free-radical metabolites and
increased levels of glutathione, a major physiologic
antioxidant.17 Curcuma longa extracts have shown
anti-inflammatory effects in rats.18

Human Trials

Curcumin exhibits free-radical scavenging ability when
administered to humans. In an open trial (uncontrolled), 18
healthy individuals ranging in age from 27 to 67 years consumed
a Curcuma longa extract, at a dose supplying 20 mg curcuminoids,
for 45 days. Before and after blood tests showed a statistically
significant decrease in lipid peroxides.19 Preliminary trials
have tested the anti-inflammatory action of curcumin, with
results that verify the traditional use of turmeric as an
anti-rheumatic herb. In a short-term double-blind, cross-over,
comparative study, 18 people received curcumin (1200 mg daily)
or phenylbutazone for two week periods. Both curcumin and
phenylbutazone produced measurable improvements in joint
flexibility and walking time. The subjects reported results only
with phenylbutazone, which may be explained by the short
duration of the trial.20 In a small placebo-controlled trial
comparing curcumin to phenylbutazone, 45 patients with
post-operative inflammation received curcumin, phenylbutazone or
placebo. The anti-inflammatory effects of curcumin and
phenylbutazone were comparable and superior to placebo.21
Curcumin has not been found to produce an analgesic (pain
relieving) effect.

Bioperine-Nature’s Absorption Enhancer
Boosts Curcumin Absorption*

Traditional Ayurvedic herbal
formulas often include black pepper and long pepper as
synergistic herbs. The active ingredient in both black pepper
and long pepper is the alkaloid, piperine. Experiments carried
out to evaluate the scientific basis for the use of peppers have
shown that piperine significantly enhances bioavailability when
consumed with other substances.22 Several double-blind clinical
studies have confirmed that Bioperine® increases absorption of
nutrients.23

Curcumin is poorly absorbed in the intestinal
tract, limiting its therapeutic effectiveness. Oral doses are
largely excreted in feces, and only trace amounts appear in the
blood. Concomitant administration of 20 mg of piperine with 2
grams of curcumin increases the bioavailability of curcumin by
2000%.24

Scientific References


1. Majeed, M., Badmaev,
V., Shivakumar, U., Rajendran, R. Curcuminoids. 1995.
Piscataway, NJ: NutriScience Publishers.
2. Srimal, R.C.
Turmeric: a brief review of its medicinal properties.
Fitoterapia 1997;68(6):483-93.
3. Ammon, H.P.T., Wahl, M.A.
Pharmacology of Curcuma longa. Planta Medica 1991;57:1-7.
4.
Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae).
The Protocol Journal of Botanical Medicine, Autumn
1995:43-46.
5. Rao, N.S., Rao, M.N.A. Free radical scavenging
activity of curcuminoids. Arzneim.-Forsch./Drug Res.
1996;46(2):169-171.
6. Bonté. F. et al. Protective effect of
curcuminoids on epidermal skin cells under free oxygen radical
stress. Planta Medica 1997;63:265-66.
7. Rao, S., Rao, M.N.A.
Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol.
1997;49:105-7.
8. Lalitha, S., Selvam, R. Prevention of
H2Os-induced red blood cell lipid peroxidation by aqueous
extracted turmeric. Asia Pacific J Clin Nutr
1999;8(2):113-14.
9. Deshpande, S.S., Maru, G.B. Effects of
curcumin on the formation of benzo[a]pyrene derived DNA adducts
in vitro. Cancer Letters 1995;96:71-80.
10. Subramanian, M., et
al. Diminution of singlet oxygen-induced DNA damage by curcumin
and related antioxidants. Mutation Research
1994;311:249-55.
11. Blasiak, J., Trzeciak, A., Kowalik, J.
Curcumin damages DNA in human gastric mucosa cells and
lymphocytes. Journal of Environmental Pathology, Toxicology and
Oncology 1999;18(4):271-76.
12. Ramsewak, R.S., DeWitt, D.L.,
Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory
activities of Curcumins I-III from Curcuma longa. Phytomedicine
2000;7(4):303-308.
13. Nirmala, C. Anand, S., Puvanakrishnan,
R. Curcumin treatment modulates collagen metabolism in
isoproterenol induced myocardial necrosis in rats. Molecular and
Cellular Biochemistry 1999;197:31-37.
14. Choudhary, D.,
Chandra, D. Kale, R.K. Modulation of radioresponse of glyoxalase
system by curcumin. Journal of Ethnopharmacology
1999;64:1-7.
15. Park, E-J. et al. Protective effect of
curcumin in rat liver injury induced by carbon tetrachloride. J
Pharm. Pharmacol. 2000;52:437-40.
16. Deshpande, U.R. et al.
Protective effect of turmeric (Curcuma longa L.) extract on
carbon tetrachloride-induced liver damage in rats. Indian
Journal of Experimental Biology 1998;36:573-77.
17.
Rajakrishnan, V. et al. Neuroprotective role of curcumin from
Curcuma longa on ethanol-induced brain damage. Phytotherapy
Research 1999;13:571-74.
18. Arora, R.B. Basu, N., Kapoor, V.,
Jain, A.P. Anti-inflammatory studies on Curcuma longa
(Turmeric). Indian J Med Res 1971;59(8):1289-95.
19.
Ramirez-Bosca, A. et al. Antioxidant curcuma extracts decrease
the blood peroxide levels of human subjects. Age
1995;18:167-69.
20. Deodhar, S.D., Sethi, R. Srimal. R.C.
Preliminary study on antirheumatic activity of curcumin
(diferoyl methane). Indian J Med Res 1980;71:632-34.
21.
Satoskar, R.R., Shah, S J. Shenoy, S.G. Evaluation of
anti-inflammatory property of curcumin (diferoyl methane) in
patients with postoperative inflammation. International Journal
of Clinical Pharmacology, Therapy and Toxicolgy
1986;24(12):651-54.
22. Atal, C., Zutshi, U., Rao, P.
Scientific evidence on the role of Ayurvedic herbals on
bioavailability of drugs. Journal of Ethnopharmacology
1981;4:229-232.
23. Bioperine®–Nature's Bioavailability
Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa
Corporation, Piscataway, N.J.
24. Shoba, G., et al. Influence
of piperine on the pharmacokinetics of curcumin in animals and
human volunteers. Planta Medica 1998;64(4):353-6.

© 2002
Doctor's Best, Inc. Revised 8/13/02

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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Gentle Giant Glycinate - Calcium / Magnesium Glycinate 1:1 ratio
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Date: July 11, 2005 01:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Gentle Giant Glycinate - Calcium / Magnesium Glycinate 1:1 ratio

Gental Giant Glycinate

as you know, minerals come in many forms. Glycinate is the body-friendly gental giant you've been searching for. Calcium and Magnesium Glycinate are fully reacted chelates of calcium and magnesium with the amino acid glycine. Cal Mag Glycinate 1:1 provides 500mg of each mineral in an ActiSorb Base of enhanced absorption.

Cal Mag Glycinate 1:1 Your Body will thank you,

Actisorb ® Base: (Bioperine [black pepper extract], Ginger root extract, Rosemary Leaf extract, Turmeric root extract, cayenne extract)



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Digest Active - For Occasional Indigestion
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Date: June 29, 2005 02:39 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Digest Active - For Occasional Indigestion

It feels great when you’ve eaten well and your body has been energized with nutrients. But with your busy schedule, you might not always be able to eat well, and your body might not have the time or energy to properly digest your meals. The result: occasional indigestion and low energy because your food doesn’t get broken down enough to release the energizing nutrients you need. And poor digestion can lead to long-term health imbalances. To reclaim the energy from your nutrients, Source Naturals, the science company, introduces DIGESTACTIV, a Bio-Aligned Formula™ designed to work with your body to stimulate optimal digestion. DIGESTACTIV contains the high potency, broad-spectrum blend of digestive enzymes found in our best-selling ESSENTIAL ENZYMES™, plus digestion-stimulating ingredients such as bromelain, papain and ginger. When you want digestive stimulation along with the nutrient releasing power of ESSENTIAL ENZYMES for occasional indigestion, take DIGESTACTIVE.

Bio-Aligned™ Digestive Support

DIGESTACTIV™ is scientifically formulated to support the body systems involved in healthy digestion. There are herbs and other ingredients to promote the digestive stimulant system and enzymes to promote the digestive systems for releasing nutrients from food. These ingredients work together to optimize the amount of energizing nutrients you can assimilate from your meals and to relieve occasional indigestion, occasional constipation, sour stomach, bloating and gas.

Digestive Stimulant System

DIGESTACTIV contains many ingredients that help stimulate your digestive process to promote healthy nutrient accessibility. Betaine HCl (hydrochloric acid) supports the acidic environment needed in your stomach to digest food. The bitter herbs gentian, ginger, peppermint and quassia all stimulate the appetite and the gastric juices needed for digestion. Bioperine® is a pepper extract that increases thermogenic, or heat generating reactions in the gastro-intestinal tract, which facilitates enhanced bioavailability of nutrients.

Nutrient Digestion Systems

DIGESTACTIV also contains enzymes that work throughout the varying sections and pH (or acidity) levels of your digestive system. For the carbohydrate digestive system, there are amylase, amyloglucosidase and lactase. Amylase and amyloglucosidase convert starch into smaller, simpler sugars. Lactase breaks down the milk sugar lactose, which many adults are unable to digest. For the protein digestive system, there are acid stable protease and vegetarian pancreatin to promote protein digestion in a wide range of pH levels. Additional protein digestion support comes from the pineapple enzyme bromelain, the papaya enzyme papain, and betaine HCl, which promotes the acidity level needed to denature proteins for digestion of their building blocks, amino acids. For the fat digestive system, there is lipase to promote the healthy breakdown of fats, or triglycerides, into their nutrient building blocks, fatty acids and glycerol.

For the fiber digestive system, there are cellulase and hemicellulase to break down the sturdy cell walls in fibrous plants, thereby releasing more nutrients for digestion.

Popular Efficacy

DIGESTACTIV contains all the key ingredients found in the best-selling ESSENTIAL ENZYMES™. ESSENTIAL ENZYMES is a popular product because it addresses body systems in addition to symptoms* of digestive imbalance. And it works. Increasing the breakdown of nutrients in the digestive system results in fewer digestive symptoms* as well as better nutrient availability. And DIGESTACTIV has added enzymes and herbs to promote digestive stimulation for relief of occasional indigestion. Source Naturals is pleased to partner with your local health food store to bring you the unique health benefits of DIGESTACTIV. There is a revolution underway in how we think about and maintain our health, and natural food stores and outlets are at the forefront. You can benefit right now—long before word spreads to the general public—with the innovative nutrition of Source Naturals DIGESTACTIVE.

Health Strategies for Digestive Wellness

  • • Eat slowly to give your body time to generate digestive juices as well as savor your food.
  • • Eat a balanced, whole foods diet to maximize your access to energizing bioavailable nutrients.
  • • Drink plenty of water to supply much needed fluid for digestion.
  • • Try to relax when eating, to promote the flow of your digestive juices.
  • • Stay active, because regular exercise helps to promote healthy digestion.
  • • Eat plenty of fiber to provide your GI tract with the bulk needed for healthy digestion.
  • • Eat probiotics, beneficial bacteria that help you digest foods These include acidophilus, which is found in yogurt, and bifidus.
  • • Eat prebiotic carbohydrates found in fruits and vegetables, such as FOS (fructooligosaccharides), to feed the friendly bacteria that live in your intestines and help your digestion.
  • • Supplement your diet with digestion promoting products such as Source Naturals probiotics ACIDOPHILUS, LIFE FLORA™, SUPER CARROT ACIDOPHILUS™, and BIFIDYN™, prebiotic NUTRAFLORA® FOS, and fibers such as CHOLESFIBER™, GRAPEFRUIT PECTIN, GUAR GUM, OAT BRAN 1000™, and PSYLLIUM HUSK POWDER.

    DigestActiv™ is a Bio-Aligned Formula™ Multi-System Support for Occasional Indigestion

    Carbohydrate Digestive System: Amylase, Amyloglucosidase, Lactase

    Protein Digestive System: Vegetal Analog of Pancreatin, Acid Stable Protease, Bromelain, Papain, Betaine HCl

    Fat Digestive System: Lipase

    Digestive Stimulant System: Betaine HCl, Bioperine®, Gentian Root, Ginger, Peppermint, Quassia

    References
    Bland. J. (1993). Digestive Enzymes. Keats Publishing Co. Holcenberg, J. et al. (1981). Enzymes as Drugs. John Wiley and Sons: New York. 331-340. Linder, M. (1991). Nutritional Biochemistry and Metabolism. Appleton & Lange. * The term symptom as used above refers to the effects of nutrient shortages or imbalances and is not related to the diagnosis, treatment, cure, or prevention of any disease.



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    Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort
    TopPreviousNext

    Date: June 02, 2005 12:37 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort

    It happens. You reach for something and feel a sudden discomfort. Your joints and muscles may feel tender from overuse. Inside, your cellular systems are out of alignment, resulting in lessened mobility. Source Naturals understands how difficult joint discomfort can be to live with. We are deeply committed to developing well-researched formulas that address the root cause of joint distress. Our Bio-Aligned Formulas™ bring alignment to multiple interdependent body systems. Only this type of indepth formulation can provide the long-term relief you are looking for. Regain your comfort with Source Naturals INFLAMA-REST. Unlike many products that contain just a few ingredients to offer temporary relief, INFLAMA-REST is a Bio-Aligned Formula™, scientifically designed to address aches. INFLAMA-REST goes deep to the underlying cause of joint discomfort. These systems include: inhibition of pathways involved in joint discomfort, joint and muscle function, DNA protection and antioxidant defense.

    Addressing Joint Comfort on a Deep Cellular Level

    Discomfort can come from many places. From your head to your toes there are many tissues that can become uncomfortable from everyday use. Joint discomfort starts when stress, such as tissue damage, causes an imbalance of the biochemical pathways on a deep cellular level. The body has its own “innate intelligence” encompassing more than just the thoughts in the brain. It consists of ongoing and complex chemical reactions regulated by a wide variety of enzymes and chemical messengers. These reactions can sometimes get out of balance – but you can control and inhibit key body chemicals that would otherwise lead to cellular irritation. For example, certain types of prostaglandins that regulate normal physiological functions such as blood flow, are maintained at low levels in all our cells under everyday conditions. In response to stress, a message is sent to the outer membranes of certain cells to convert their fatty acids into arachidonic acid, the raw material for prostaglandins. This stress also directs cells to produce Cyclooxygenase enzyme- 2 or COX-2. This enzyme converts arachidonic acid into Prostaglandin E2, a particular type of prostaglandin specifically responsible for irritation on a cellular level. The result: joint discomfort. But that doesn’t have to happen. By supporting inhibition of the culprit COX-2, you can decrease Prostaglandin E2 production to bring your joint tissues back into a healthy and comfortable balance.

    Support COX-2 Inhibition

    INFLAMA-REST includes herbs that support inhibition of COX-2 in a variety of pathways. Ginger, turmeric and green tea all support direct COX-2 inhibition. But there are other places in our biochemical communication system where COX-2 production can be inhibited. Two additional factors that lead to COX-2 production are nitric oxide and the enzyme that produces it, nitric oxide synthase (iNOS). Nitric oxide is a free radical associated with cell growth and regeneration, blood vessel elasticity and COX-2 enzyme production. Resveratrol, rosemary and turmeric support iNOS inhibition, thus inhibiting your body’s over-production of nitric oxide and the COX-2 enzyme. A related irritation factor is also one of the latest scientific discoveries in cellular health - Nuclear Factor kappa-B (NF-kappa-B). NF-kappa-B works at the DNA level – at the blueprints of cells. When activated, this factor controls the genes that regulate cell growth, differentiation and regeneration. And blocking this factor is also associated with inhibition of both COX-2 and iNOS enzymes. Stinging nettle, milk thistle and Chinese Skullcap all block unhealthy NF-kappa-B activation in your body and thereby help support COX-2 inhibition.

    Cytokine Inhibition

    Compounds called cytokines, or interleukins, can also stimulate biochemical pathways leading to joint discomfort. Cytokines are chemical messengers produced by the immune system to regulate defensive activity when they are stimulated. For example, cytokines are released by macrophages in response to stimuli such as tissue damage. This results in rapid escalation and amplification of cell number and response. Constant stress can shift this system out of balance, resulting in tissue discomfort. Bringing these compounds back into balance can preserve your short-term comfort and longterm health. INFLAMA-REST contains curcumin from the spice turmeric. Curcumin assists the body’s inhibition of cytokine activity to support reduced cellular irritation. And Bioperine®, which is derived from black peppercorns, is added to assist curcumin assimilation.

    Stress Response: Joints and Muscle Support

    Inhibition of chemical messengers involved in joint discomfort is just part of a Bio-Aligned strategy for relieving discomfort. Research has shown that emotional stress, particularly long-term, can directly affect the body and set in motion mechanisms that cause physical discomfort. Ashwaganda and Chinese Skullcap (S. baicalensis) are herbs that help modulate the body’s response to stress and may help ease aches and discomfort. Boswellia, ginger, quercetin, milk thistle, feverfew, Oregon grape root and bromelain (an enzyme found in pineapples) provide additional soothing relief to your cells and tissues. Essential nutrients are also vital to maintaining your joint comfort. The tocotrienol forms of vitamin E, along with selenium, protect cell membranes from lipid-based free radicals. Magnesium aids energy metabolism in muscles and can reduce tenderness as well as muscle spasms. Zinc is essential for normal cellular repair mechanisms such as wound healing and is important for the growth and maintenance of connective tissue. And manganese works to protect cells from oxidation and to build healthy connective tissue as well, an essential component of healthy joints and muscles.

    Protecting Your DNA

    To reduce cellular irritation, you need to protect the DNA in your cells. DNA is the blueprint for all of the molecules in the body. If your DNA is altered or damaged, then needed molecules may not be produced, leading to short-term and eventually long-term damage. Curcumin, from turmeric, has been shown in in-vitro studies to protect DNA against strand breakage. Quercetin has also been shown to directly protect DNA against strand breakage and base oxidation from free radicals and damaging chemicals, according to recent in-vitro research.

    Providing Powerful Antioxidant Cellular Protection

    Antioxidants are selfless bodyguards of your cells. They donate their own electrons to stabilize free radicals in your body. Thus, antioxidants absorb the damage that would have been done to your tissues. Some regulatory chemicals, such as Nitric oxide, are powerful free radicals and oxidants. Oxidants also activate NF-kappa-B. Tissues, lipids, proteins and DNA are extremely sensitive to oxidation. Quercetin, milk thistle, turmeric, ginger, rosemary, vitamin E and resveratrol are all antioxidants that help modulate the activity of these compounds as well as protect cells and tissues from damage. Plus, Superoxide Dismutase (SOD), one of the most important enzyme antioxidants found in your body, has been added in a new cutting-edge form. The vegetarian SOD used in INFLAMA-REST is attached to Gliadin, a wheat protein, that has demonstrated significantly better absorption than SOD alone.

    Six Lifestyle Strategies for Fewer Aches


    1. Try Yoga or Tai Chi. Low-impact exercise based on slow fluid movements can improve mobility and flexibility as well as greatly reduce stress.
    2. Get in the pool. Exercising while in the pool reduces strain on the joints in addition to strengthening muscles.
    3. Maintain a healthy weight. Excess weight adds pressure to joints and connective tissues.
    4. Eat omega-3s. Omega-3 fatty acids found in salmon, flax seeds, or in supplement form support healthy joints and tissues.
    5. Stay hydrated. Water is the basis of lubrication in connective tissues such as joints and skin and also supports detoxification.
    6. Supplement with glucosamine, chondroitin, MSM and hyaluronic acid. These supplements can help maintain healthy connective tissues. Source Naturals is pleased to partner with your local health food store to provide INFLAMA-REST as a comprehensive Bio- Aligned Formula for relieving joint discomfort by protecting, nourishing and soothing irritated cells. Make INFLAMA-REST part of your health plan to live without joint discomfort.

  • INFLAMA-REST is a Bio-Aligned Formula™ Multi-System Support for Joint Comfort

    Inhibition of COX-2: Turmeric, Ginger, Chinese Skullcap, Green Tea, Resveratrol, Boswellia, Silymarin, White Willow Inhibition of Cytokine Turmeric, Stinging Nettle, Feverfew Inhibition of Rosemary, Green Tea, Resveratrol, Turmeric, Quercetin, Chinese Skullcap NF-kappa-B Activation Silymarin, Chinese Skullcap, Stinging Nettle, Rosemary, Resveratrol Stress Response: Ashwaganda, Magnesium, Chinese Skullcap, Oregon Grape, Feverfew, White Willow DNA Protection Turmeric, Quercetin, Rosemary Antioxidant Defense Silymarin, SOD Gliadin, Turmeric, Rosemary, Tocotrienols, Resveratrol, Ginger, Selenium, Manganese, Zinc Prostaglandin & Leukotrine Synthesis Joint & Muscle Support Inhibition of Nitric Oxide Synthesis Production



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    COENZYME Q10 - Transforming food into energy
    TopPreviousNext

    Date: June 01, 2005 11:06 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: COENZYME Q10 - Transforming food into energy

    Coenzyme Q10

    It’s 3:30 p.m. and you feel irritable; you can’t seem to concentrate. You were so busy you skipped lunch. At last you bite into the sandwich that you were ready for 3 hours ago. By the time you have eaten half of it, energy is starting to flow through you. What happened? The answer to that question is both extremely complex and very simple. In essence, your body transformed the food into useable energy. CoQ10 is a crucial component of the primary energy generating cycle that takes place in each of the trillions of cells in our bodies. CoQ10 is essential for human life.

    To transform that lunchtime sandwich into useable energy your body essentially has to burn it - just the way a car burns gasoline to drive its engine. This energy generating process takes place in structures called mitochondria - tiny power plants which are within every cell. Inside these energy generating stations, fats, sugars, and amino acids are transformed into ATP, an energy-rich molecule sometimes called the “energy currency” of the body.

    Energy Generation Requires Nutrients

    The body requires many nutrients in order to perform the complex biochemical processes that convert food into ATP “energy currency.” Some of these nutrients such as the B-vitamins are familiar to us. However, there are many other substances which are essential to this process. Coenzyme Q10 is one of these.

    Functions of CoQ10

    Several complex metabolic pathways are required in order for the body to transform that lunchtime sandwich into energy that you can feel and use. First glycolysis and the Krebs’ cycle break down large molecules of protein, carbohydrate and fat into smaller components. CoQ10 is a key enzyme in the Electron Transport Chain - the final stage in this extraordinary design. This pathway generates 90% of the ATP needed by the body from the food we eat. ATP provides the “energy currency” for the following crucial metabolic functions: 1) synthesis of cellular components including cholesterol and proteins (formed primarily by the liver), 2) nerve conduction (in the brain and peripheral nerves), and 3) energy for muscular contraction (of the heart and skeletal muscles). The Heart: The heart muscle (myocardium) consumes a tremendous amount of energy. Your heart beats over 100,000 times and pumps 1,000 gallons of blood each day! CoQ10 is necessary for the generation of the energy required by the heart. Numerous scientific studies have demonstrated that supplementation with this nutrient may support normal heart function. Its presence is necessary for cardiac performance during exercise as exemplified by criteria including: blood flow, oxygen utilization, contractility and exercise tolerance. In addition, CoQ10 may play a role in the regulation of blood pressure. The Gums: Since the 1970’s scientists have been researching the effects of CoQ10 on the health of the oral tissues. Although the mechanism of action is not known, research has established that CoQ10 has a profound ability to preserve and maintain the health of the gums. Antioxidant Properties: CoQ10 plays an additional vital role in our metabolism as a protector of lipids in cell membranes. Laboratory studies have also shown that CoQ10 is more efficient than vitamin E, beta carotene or lycopene in safeguarding LDL cholesterol from oxidation by peroxides. This process is important for maintaining the health of our blood vessels.

    Energy Insurance

    CoQ10 is needed in body tissues where energy production is critical, such as the liver, brain and muscles. Therefore we include CoQ10 in significant potencies in many of our premium formulas, such as Life Force Multiple™, Élan Vitàl™, Heart Science™, Liver Guard™, MenoBalance™, Higher Mind™, MegaMind™ and Wellness Multiple™. We also offer a combination of CoQ10 and Lipoic Acid (30 mg each), CoQ10 Sublingual (30 mg and 60 mg), 30 mg CoQ10 Softgels with Bioperine® and 30 mg CoQ10 NutraSpray™. Our single CoQ10 products are CoQ10 in 15 mg, 30 mg, 75 mg, 100 mg, and Ultra Potency 125 mg caps.

    References
    1) Folkers et al., BCACQ, Elsevier, 1977
    2) Judy et al., BCACQ, Elsevier, 1984.
    3) Kamikawa, T. et al., American Journal of Cardiology, Vol. 56, August 1, 1985, p. 247-250.
    4) Nohara et al., Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1984.
    5) Packer, L., Oxidative Stress and Aging, Birkhauser Verlad, 1995.
    6) Stocker, et al., Proceedings of the National Academy of Sciences, Vol. 88, pp 1646-1650, March 1991.
    7) Tortora, G. Principles of Human Anatomy, 4th Ed., Harper & Row, New York, 1986, p. 301.
    8) Wilkinson and Arnold, Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1977.
    9) Yamagami et al., Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1977.



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    Immunomodulating and anti-tumor action of extracts of several mushrooms
    TopPreviousNext

    Date: May 18, 2005 10:11 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Immunomodulating and anti-tumor action of extracts of several mushrooms

    Quote from Abstract:

    The outcomes obtained in the experiments in vitro have predetermined check of these extracts on antitumor effect in experiment in vivo.As a model of tumor growth, one of the most malignant tumors melanoma B16 was selected.

    AHCC with proper diet and nutrition could help reduce tumor size and/or reverse cancer in humans as shown in lab animal examples.



  • AHCC Complex 30 ct from Source Naturals

  • AHCC Complex 60 ct from Source Naturals

  • AHCC Complex with Bioperine for absorption 60ct from Source Naturals

  • AHCC Complex with Bioperine for absorption 30ct from Source Naturals

  • AHCC Plus 30ct from Source Naturals

  • AHCC Plus 60ct from Source Naturals



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