Search Term: " Chemisry "
Your Mood and mental health
September 20, 2016 11:52 AM
Bipolar disorder is a terrible mental disease that affects millions of people worldwide. It is characterized by periods of severe depression, followed by periods of extreme euphoria. It can be rapid cycling, which means the person with the disease goes through many moods a day.
Once you figure out what the underlying cause such as brain chemistry, then you can take a natural approach to help boost serotonin or dopamine.
Always remember to be careful if on MAO inhibitors or SSRI inhibitors before taking natural remedies like 5-htp or dopabean to mess with serotonin and dopamine levels in the brain.
L-Alanine Non Essential Amino Acid
January 05, 2009 04:31 PM
L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry.
Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein.
10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms.
L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and sustained running, muscles produce lactate and also alanine.
The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy.
The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-ketoglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose).
The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea.
In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction.
L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition.
A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high.
Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps.
Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure.
Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.
Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.
Inositol And Choline
December 11, 2008 12:19 PM
Inositol is a member of the vitamin B complex family, being referred to as vitamin B8, but is not strictly a vitamin because it is biosynthesized in your body. Vitamins are essential substances that are not manufactured by your natural biochemistry, and must be taken in your diet. However, to all intents and purposes it works like a member of the vitamin B family.
The main function of myo-inositol (the commonest isomer of inositol) is in the health of cell membranes, particularly those that comprise the marrow, eyes, intestines and the brain. Without proper regulation of the cell membrane, the cell cannot function effectively. Some of its effects include healthy hair and controlling estrogen levels. It is also believed to help to reduce cholesterol levels in the blood.
A deficiency will result in hair loss, eczema, increased blood cholesterol levels and eye abnormalities. You might also suffer constipation, although this is not as serious a condition as those preceding. It is present at highest levels in the heart and brain, which indicates where it is mostly used, although it also helps the liver to break down fats and enables the nerves and muscles to operate as they should.
Those that are depressed are frequently found to have low inositol levels in their spinal fluid, so it is believed to play a part in that condition. It is known that the substance takes part in the function of the neurotransmitter serotonin, which is known to play a part in depression, and initial signs are that its use in the treatment of depression could be effective. Neurotransmitters are responsible for passing messages across the gap (synapses) between nerve cells, their messages being decoded by the neuroreceptors. A healthy nervous system depends on healthy neurotransmitters.
For these reasons, inositol has also been tried on other conditions of the nervous system. These include bipolar disorder, bulimia, panic disorder, obsessive compulsive disorder and attention deficit disorder. So far, results have been inconclusive as to its effectiveness, but it is early days yet and field tests are continuing.
A test carried out in Beersheva, Israel, in 1997, found that treatment with inositol produced significant improvement in the depression of 28 patients after four weeks on the Hamilton Depression Scale1, and 21 patients tested with panic disorder (with and without agoraphobia) showed significant improvements in their condition, including agoraphobia. Results on 13 patients with obsessive compulsive disorder also showed significant improvement. These were all double-blind tests.
However, not all tests have been so conclusive, and a study on 42 people with sever depression who did not respond to conventional antidepressant, also failed to respond when inositol was added to their medication.2 Results are therefore not conclusive.
Four hundred people took part in a double-blind test that indicated a possible improvement in the symptoms of polycystic ovary syndrome when treated with inositol 3,4 and another that inositol treatment on patients taking lithium could help reduce the symptoms of psoriasis, a skin condition believed to be caused by a reaction of the immune system and nerves.5
The supplement has also been found to be just as effective as Luvox (fluvoxamine – similar to Prozac) after four weeks treatment. Although these results are good, they are inconclusive, and more data is need before any indisputable conclusions can be drawn. However, treatment with inositol might be worth considering if conventional treatment for these conditions has been unsuccessful.
The most common natural form of inositol is myo-inositol, an isomer of cyclohehexanehexol, a carbocyclic polyol that form the structural basis for secondary messengers in the cells of eukaryotes.
A secondary messenger system is one whereby a signaling molecule is released in response to a signal from a primary messenger such as a neuroreceptor, which then activates certain intracellular proteins known as effector proteins that exert a response from the cell. An example is cAMP (cyclic adenosine monophosphate) that is a secondary messenger that activates protein kinases and allows them to phosphorylated proteins.
Eukaryotes are organisms that contain cells composed of complex components contained within a cellular membrane, and that also contain a nucleus. Examples are fungi, plants and all animals. Examples of non eukaryotes include the bacteria family.
It is frequently recommended that inositol is most effective when taken with an equal amount of choline, although this might be due to the fact that when inositol deficiency is detected, choline is also frequently deficient. Both are vitamin B family like, and both are lipotropic, in that they aid the breakdown of fats in the body. It is not clear whether this is true or not, but taking both would certainly not harm you, and might be of great benefit.
Inositol is not essential, because it can be obtained from beans, nuts, seeds, whole grains, cantaloupe, brewer’s yeast, liver and vegetables. Bacteria in the gut also act on the phytic acid (inositol hexaphosphate) contained in citrus fruits to form inositol.
However, be careful if you drink a lot of coffee. It destroys inositol, and if you are taking the supplement medicinally, steer clear of coffee during your period of treatment because it will lose its effect. Excessive coffee drinking can also result in a general depletion of inositol from your diet, and hence a deficiency. In such a case you are advised to take a supplement, preferably along with choline that might also be deficient.
Although there have been no adverse side effects reported, no specific longer term safety studies have been carried out on inositol. Because of the way it works, inositol should be avoided by people with liver or kidney disease, and also by expectant or nursing women. It should be avoided by young children until safety tests have been carried out, and it is believed that it can cause manic effects in those suffering bipolar disorder.
Other than for these specific cases, trials with many times the average daily intake of the substance, it currently appears safe to take inositol as a long-term supplement. However, as with all such supplements intended for specific disorders, you should seek the advice of your physician.
References: 1. Levine J: Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev,Beersheva, Israel ur Neuropsychopharmacol, 1997 May, 7:2, 147-55
2. Nemets B, Mishory A, Levine J, et al. Inositol addition does not improve depression in SSRI treatment failures. J Neural Transm. 1999;106:795-798.
3. Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003;7:151-9.
4. Gerli S, Papaleo E, Ferrari A, et al. Randomized, double-blind, placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. 2007;11:347-354.
5. Allan SJ, Kavanagh GM, Herd RM, et al. The effect of inositol supplements on the psoriasis of patients taking lithium: arandomized, placebo-controlled trial. Br J Dermatol. 2004;150:966-969.
Green Tea Extract
October 23, 2008 01:43 PM
Green tea is a form of tea made from the leaves of the Carmellia Sinensis, a shrub that is native to China and has spread to other areas of Asia including Japan and the Middle East. Drinking it is believed to impart many health benefits, including the prevention of obesity, heart disease and some forms of cancer and it has been used in traditional Chinese medicine for over 400 years.
Tea is known to have been consumed in China for around 5,000 years, and used, not only in Chinese medicine, but also in that of Japan, Thailand and India for a number of ailments including regulating blood sugar, treating wounds and digestive problems. The drinking of green tea to benefit the heart and other vital organs is described in the Kissa Yojoki (Book of Tea), written in 1191 by Eisai, a Japanese Zen priest.
This two-part book talks about the various medicinal benefits of green tea, such as preventing fatigue, curing beriberi, quenching thirst, clearing the thoughts, maintaining health of the urinary tract and improving digestive problems. It also explains how to grow tea and how to prepare and use the leaves. The methods of treatment of various ailments and medical conditions are described in the second part of the book.
The active ingredients in green tea are catechins, polyphenols with strong anti-oxidant properties. Antioxidants are important components of your diet due to their effect on free radicals. These are small molecules, generally oxygenated, such the superoxide cation and hydrogen peroxide that are generated during normal metabolic processes and also ingested in pollutants such as traffic and factory fumes and insecticides. Free radicals are also formed by the effect of the ultra-violet component of sunlight on your skin and other tissues.
The effect of free radicals on your body can be devastating, and they not only destroy cell membranes but also oxidize such molecules as the low density lipids (LDL) that carry cholesterol around your bloodstream. This allows the LDLs to be absorbed by the white blood cells and then deposited as fatty plaques in the walls of your arteries. The end result is a thickening and hardening of the arteries that leads to a condition known as atherosclerosis, where the blood supply to the brain and heart muscle is restricted, which can in turn lead to strokes and heart disease.
Their effect on your cells is to cause cancer and premature aging, among others, and free radicals are also believed to play a part in conditions such as Alzheimer’s and Parkinson’s disease and also inflammatory diseases such as arthritis and diabetes. They can also cause damage to your DNA.
It is essential, therefore, that these free radicals are destroyed as quickly as they are generated, and that is what antioxidants do. You might be more familiar with the antioxidants Vitamins A, C and E, and phytochemicals such as flavonoids and carotenoids, but there are many substances available to you that are even more powerful such as the polyphenols found in green tea.
Epigallocatechin gallate (EGCG) is the most powerful of these with antioxidant properties at least twenty five times that of Vitamin E, and 100 times that of Vitamin C. EGCG comprises around 10-50% of the total catechin content of the tea and studies indicate that it likely helps to protect against DNA damage by free radicals, to protect against oxidation of LDL, provide protection against the damage of ultra-violet radiation and to protect you from the free radicals that are generated by smoking tobacco and general airborne pollution.
There are suggestions that the bioavailability of EGCG can be increased by consuming black pepper when drinking green tea, possibly due to the presence of piperine in the pepper. The piperine appears to retard the intestinal glucuronidation of EGCG and so allow more of it to be absorbed as opposed to excreted. So if you are using green tea for health reasons, spice up your food with a small amount of black pepper - that's all it needs. You don't have to smother your food in it! It should be stressed that these tests were carried out on animals, although the biochemistry involved is much the same.
The oxidation of fat by your metabolism to provide energy is a very important factor in weight control. If the contribution of the fats you ingest to the energy generated by your metabolism is low, then the fats can go on to be deposited in your body. This is not only unsightly, in that it can basically make you look 'fat', but is also dangerous to your health. Fat deposits around your midriff and round the major organs of your body can be extremely damaging and a severe risk to your health.
It has been shown by a recent study in the UK (Birmingham University) that those taking green tree extract displayed a 17% increase in fat oxidation over those given a placebo. Not only that, but the ratio of fat oxidation to the overall energy expenditure showed a similar differential between the study and the control group. This provides evidence of green tea extract being able to control your weight by burning fat, and also to improve the tolerance to glucose and sensitivity to insulin of healthy people.
Many other health claims have been made for green tea extract, although many of these have little, if any, scientific basis. Among these are the claims that it can treat multiple sclerosis and be used to treat cancer, although claims that it can prevent the destruction of cell membranes due to its oxidative effect are supported by the biochemistry, if not the medical proof. There are cases where theoretical biochemistry can explain many of the applications of ancient remedies without needing modern day studies to support it.
Some of the research supporting the green tea theories include:
1. In 2006, a study was announced that had followed over 40,500 Japanese men and women, aged between 40 and 79, that had no history of coronary heart disease, stroke or cancer starting in 1994. It was found that those who drank at least 5 cups of tea per day had a 16% lower risk of dying from any cause and a 26% less risk of dying from cardiovascular disease than those that drank less than one cup of tea each day. Since cardiovascular disease and cancer are the major causes of death world-wide, these are significant results.
2. Again in 2006, it was reported in the American Journal of Clinical Nutrition that studies indicated that a higher consumption of green tea was associated with a reduction in human mental impairment when compared to the average.
3. Yale University School of Medicine reported later that year that, in spite of smoking more than their western counterparts, Asians suffered lower rates of cancer and heart disease, and put that down to them drinking over 4 pints of green tea daily. It was the polyphenol content of green tea and its antioxidant effect that was proposed for this result, known commonly as the 'Asian paradox'. A specific reason given for this was the antioxidant effect preventing the oxidation of LDL cholesterol, and its subsequent deposition in the artery walls.
4. Another component of green tea is the amino acid L-Theanine that promotes relaxation, and it is believed that this could help to fight stress by inhibiting the excitation of cortical neurons.
There is a lot more evidence for the health benefits of green tea, and once again it appears that the ancients have been proved correct. Perhaps we should pay more attention to ancient remedies, although without the proper evidence much of it is ignored - for the time being at least. Green tea, however, has generally been accepted due to the research and studies carried out on ECGC (Epigallocatechin gallate) and in additional to the traditional form, is also available as a dietary supplement.
August 29, 2008 09:20 AM
Gamma Oryzanol is extracted from rice bran oil, and is a mixture of substances that includes ferulic acid and sterols. It is not restricted to rice barn oil, and is also found in the bran of other grains, and some fruits and vegetables. It is commonly used as a sports supplement, although possesses other uses including treatment of menopausal symptoms and high cholesterol levels.
Athletes use gamma oryzanol to increase their muscle bulk through it increasing the levels of testosterone and other anabolic hormones. Although there is little scientific evidence for these effects, bodybuilders claim excellent results and the other benefits that the substance offers make it worthwhile taking. The reported benefits are so common and widespread that they are difficult to ignore, and it can be assumed that, in the absence of scientific evidence through test results, the athletes and bodybuilders are right until proven wrong.
Gamma oryzanol is reported to promote a number of metabolic effects on the body such stimulation of the Human Growth Hormone that is involved in increasing muscle bulk. It also induces increased release of endorphins, and improves recovery after exercise. Ferulic acid promotes increased strength, reduced fatigue and improved recovery.
The catabolic effect of cortisol is also reduced. Cortisol is produced during exercise and it is destructive to muscle tissue. What this does in practice is to increase your recovery time, and after a long run it can take two days to recover and allow your exercise effectively again. It is important that your body is conditioned to rapidly reduce its cortisol content after exercise, and ferulic acid helps you to do this.
Athletes have reported no side effects from doses of up to 900 mg of gamma oryzanol and 60 mg ferulic acid, which appears to be up to thirty times as bioavailable to the human body as gamma oryzanol. However, there are many more uses of the supplement than just metabolic ones.
Gamma oryzanol possesses strong antioxidant properties. Ferulic acid is a phenolic phytochemical, and a derivative of trans-cinnamic acid. As such, it is an antioxidant with strong reducing properties towards free radicals. Free radicals are implicated in cardiac problems cause by the oxidation of LDL cholesterol, leading to atherosclerosis that is responsible for strokes and blockages of the cardiac arteries.
Lipid peroxides can be formed by the oxidization of fats, and can damage nerve cells and muscle tissue. Antioxidants can also lead to premature aging through the destruction of human body cells, damage to DNA and also many forms of cancer. Although it is believed that components of gamma oryzanol can inhibit the initiation of some cancers, the evidence is still scanty and the research in its infancy.
Any substance that destroys free radicals is of benefit to your health, and Ferulic acid stands beside other strong antioxidants such as Vitamins A, D and E, and many of the high colored phytochemicals such as beta carotene. It is believed to have anti-cancer properties with some forms of cancer, such as breast and liver cancer, though, as referred to above, studies are continuing.
Paradoxically, intensive physical exercise can lead to the generation of more free radicals, since they are a by-product of the generation of energy in the mitochondria from blood glucose, and so, in addition to its beneficial metabolic and anti-catabolic properties, gamma oryzanol should be taken during exercise in order to reduce the effect of these dangerous molecules.
The effect of gamma oryzanol on cholesterol levels has been demonstrated, and complement the same effect offered by the fatty acid component of the bran oil. It appears to prevent the absorption of cholesterol by the digestive tract, and so allow it to be excreted naturally before doing any harm. It is believed that the phytosterols present in rice bran oil block the cholesterol absorption sites in the intestine, so is must continue down the intestinal canal until it is evacuated.
Cholesterol itself is essential to human metabolism and biochemistry, and without it we could not survive. Cholesterol is not soluble in water, and it has to be bound to low density lipids (LDL) to enable it to be transported round the blood to where it is needed: usually in the arteries to heal up arterial damage, a bit like a sticking plaster.
However, free radicals oxidize these LDLs and deposit them along with their cholesterol on the artery walls: that is the problem, not the cholesterol itself, and is why antioxidants such as gamma oryzanol are so important to us. Rice bran oil has been used by the Japanese for many years to treat elevated cholesterol levels and also to reduce high triglyceride levels.
It also acts as an anti-inflammatory, specifically in the stomach and can be used to treat gastritis, in that it reduces the inflammation of the stomach lining. There is some evidence from studies on animals that the substance could be effective in treating gastric ulcers, although the results with animals have not yet been tried on human subjects. Another mechanism, other than the anti-inflammatory route, is through the normalization of the secretion of the gastric juices.
Another use to which gamma oryzanol has been successful put is in the treatment of menopause symptoms. This is another of those situations where some trials have proved unsuccessful, but those that use it has found it be effective. Hot flashes and aging syndromes are two symptoms that have been effectively treated by use of the supplement, with one study reporting a 50% reduction in symptoms in 70% of patients.
The way this is theorized to work is through the inhibition of the secretion of leutinizing hormone by the pituitary gland, which promotes the hypothalamus to release endorphins. Endorphins help to overcome the effects of the menopause.
Gamma oryzanol, then, has found use by many athletes and bodybuilders in its metabolic properties in helping to increase muscle bulk and reduce fat, and by shortening recovery times by reducing the catabolic effect of cortisol. However, apart from these sports-related benefits, it possess antioxidant and anti-inflammatory properties that are beneficial to your general health.
August 22, 2008 05:50 PM
Fructooligosaccharides, which shall henceforth be referred to as FOS for obvious reasons, are sugars with chemical linkages known as osidic covalent bonds that resist enzymic hydrolysisis, and so are broken down by neither the salivary nor the digestive enzymes. In other words, they are indigestible.
However, before discussing the biochemistry further, let's have a look at what they can be used for. Your body depends upon certain bacteria for its health. These are essential to help break down and digest certain foods, and also to provide a resistance to disease and infection. FOS is what is known as a prebiotic, which used to feed these friendly bacteria. Just like any other living organism, bacteria require nourishment and while they get plenty of food from our own diet, especially from the fiber content, they find FOS particularly appetizing.
Because fructooligosaccharides cannot be digested, it passes unchanged into the colon, where these bacteria live. As they break down the FOS and live on it, they multiply, and create an environment in your lower intestine that is hostile to many harmful bacteria such as Clostridia and E. coli. However, it is not only these harmful bacteria that cause problems with your digestion since there many other agents that can interfere with the smooth functioning of your gastrointestinal tract.
People all over the world are continually suffering from both minor and very serious digestive problems, ranging from heartburn and upset stomachs to severe diarrhea, Crohn's disease, irritable bowel syndrome and even bowel cancers. There is a multitude of reasons for that such as the effects of aging, poor diet and bacteria from contaminated food. Organic foodstuffs do not last long in many warm countries, and while spices can be used to hide the taste, they are not always successful in killing off the bacteria.
Your health depends on a healthy digestive system, and when that is wrong then you will feel ill. If your digestive system is running below par, then you will not feel good, and could suffer from a wide range of symptoms, including tiredness, nausea, constipation, diarrhea, fevers and depression. The health of your intestinal tract in particular is often neglected, and most people need to do something to give it a boost and improve its, and their, overall health.
That is what FOS can do. And it can do more than just feed friendly bacteria: it can help you maintain regular bowel movements, maintain healthy blood sugar levels, maintain a healthy immune system, break down hormones and rebuild them again (it is useful for the relief of the symptoms of PMS) and to keep down the cholesterol and fatty acid levels in your blood. It is used to feed beneficial bacteria, not to replace them, and if you are on a probiotic supplement, you can take FOS along with it.
Fructooligosaccharides are also used as artificial sweeteners, and alternative names for them oligofructan and oligofructose. There are two classes of FOS, the first of which is produced commercially by the chemical or enzymic degradation of inulin, a polymer of D-fructose linkages terminated with D-glucose. This is produced commercially predominantly in Belgium and Holland, and it also occurs naturally in chicory and Jerusalem artichoke, and in lesser amounts in bananas, garlic, tomatoes and onions. The second class of FOS is produced mainly in Japan. This is produced by a process known as the transfructosylation of a B-fructosidase from saccharose or aspergillus niger, a black mould found on onions and grapes. This is basically the same as the first class, although the chemical bonds are in different places.
While they resist breakdown by enzymes, they are fermented in the colon by anaerobic bacteria, bacteria that work in the absence of oxygen. Because they are fairly soluble, they can be added to dairy products such as yoghurt and used to feed the bacteria contained in the yoghurt. In fact many supplements containing acidophilus bacteria are fortified with FOS: you drink the bacteria along with its food.
Although FOS is only now assuming increasingly popularity in the West, it has been used as a dietary supplement in Japan for many years. Some of the specific health benefits that FOS coveys by promoting the health of essential bacteria, are:
Calcium and Magnesium Absorption
There have been several studies that have concluded that FOS and inulin improve the absorption of calcium in the intestine of both animals and humans. The fermentation of the FOS by bacteria reduces the pH of the gut, which increases the solubility of these minerals and hence extracts more of them from food. The increased solubility also helps them to be more easily absorbed through the intestinal wall into the bloodstream. FOS can therefore help to maintain bone density and prevent osteoporosis.
Strengthened Immune System
By taking a supplement of FOS, you can increase the density of friendly bacteria in your gut fivefold in a matter of weeks. This crowds out harmful bacteria, and so the level of toxins in your body is reduced. Your immune system is allowed to work properly to fight of infection and disease without having to work hard on keeping down the harmful bacteria in your gut.
Apart from being a food for bacteria, since it is not digestible FOS is also a soluble fiber that draws water into your colon, and so promotes easy transport of feces by the peristaltic pumping action of the intestinal muscles. It also absorbs excess water in the chyme and feces and so helps to prevent diarrhea. Furthermore, improving the health of the friendly bacteria also improves your digestive health that also promotes regularity.
The fermentation of FOS by bacteria produces gases and acids. These acids help the body to produce energy, and although not a massive energy boost, when allied to the improved digestion it is significant.
All of these benefits and more suggest that FOS is highly recommended in the event of sporadic and chronic gastrointestinal problems. It is a natural substance that does not have a direct influence on your body's biochemistry, but promotes the health and reproduction of those bacteria that do have a significant influence on intestinal health. Add that to the added benefits discussed above, and FOS is one of these supplements that could almost be called essential.
Can the Fatty Acid CLA Help me Lose Weight ?
July 14, 2008 03:28 PM
CLA is conjugated linoleic acid, a compound known as a trans fatty acid due to its stereochemistry, and while trans fatty acids are generally regarded as harmful, CLA is not because it is conjugated. This means that it has alternate single and double bonds in the backbone carbon chain, and the overall energy of the molecule is therefore reduced.
Linoleic acid itself is one of the omega-6 fatty acids, the 6 referring to the double bond at the sixth carbon from the omega and of the carbon backbone chain. It is believed to be the cause of heart disease and obesity due to its increasing use in the diet at the expense of omega-3 fatty acids. When the molecule is conjugated, however, the fatty acid has different chemical properties to the standard isomer, and natural CLA is mainly found in cattle products, such as beef and dairy products.
Conjugated linoleic acid is present in cattle because it is formed when linoleic acid is converted to oleic acid by rumen bacteria, that are responsible for the microbial fermentation of the feed of ruminant animals such as sheep and cattle. When oleic acid is formed, so too is CLA. However, the form used in supplements is manufactured from vegetable oils, and therefore suitable for use by vegetarians. The usual vegetable oils used are safflower oil and sunflower oil.
It is believed to possess several beneficial properties, including antioxidant and anti-cancer properties, but it is for its ability to reduce body fat that it is best known to most people. A growing amount of information is being collected on the use of CLA as a supplement in the weight loss industry, although there are as yet no definitive mechanisms that explain its action. However, recent studies have indicated it possess properties that can help to reduce the levels of low density lipoproteins in the blood, and reduce the possibility of atherosclerosis due to LDL oxidation by free radicals.
It is also theorized that CLA in some way regulates the prostaglandin biosynthesis that controls the level of hormones in the body that can regulate growth. An increase in growth hormones is one way in which athletes promote an increase in muscle bulk, while reducing their fatty tissue mass. CLA is also purported to increase thermogenesis, and so promote the loss of body fat and overall weight.
Although most studies on the effect of conjugated linoleic acid in reducing body weight have been carried out on animals, recent animal studies have indicated that might not so much reduce weight, as to increase muscle bulk while reducing that of body fat. The end result, therefore, is not a loss of weight, but a leaner body that has more muscle and less fat. All it needs is the results on animals to be transferred to humans, and this, of course, is frequently the case. However, initial studies on the use of CLA in the human diet have been very positive, so the signs are good.
Most scientific progress in human biochemistry has been obtained by virtue of prior studies on animals. These studies, of course, have been beneficial to the animals, making them leaner and much fitter than they otherwise would have been. It is believed that the same will be true of humans taking CLA as a supplement. In fact, recent studies are split about 50/50 with regard to the effects on humans.
While some studies have shown no benefit, about an equal number have shown a positive benefit in the reduction in the mass of fat in the body. Some of the negative studies may have been flawed in measuring total body weight, and not the relative amounts of muscle and fat, and also basing their results on people already with a low level of fat in their body. In that respect, then, the results look very favorable, and taking CLA as a supplement is likely to help you to reduce fat and increase muscle, if not altogether lose total body weight. However, is that not the end result that most people want? They might not want to be lighter in weight, just to have more muscle mass and less fat tissue.
In a study shown at a 2002 Experimental Biology meeting, it was shown that is was possible to substantially reduce body fat mass by taking CLA alone, and when it was taken in association with guarana, both the size and the number of fats cells in the body were reduced by 50%. However it has also been shown that CLA can be oxidized by free radicals shortly after ingestion, and that sesame lignans help to prevent this. Since sesame lignans can also be used in conjunction with CLA to reduce fat by increasing the level of fatty acid oxidation in the liver, than the benefit of CLA seems obvious.
The antioxidant effect of CLA is one possible explanation for its anti-cancer properties, though there are others. Its antioxidant properties also have an anti-catabolic effect, in that it can help to prevent the wastage of muscle tissue. The FDA has published studies that attest to these anti-cancer properties. Diabetics, however, should consult with their physician before taking CLA as a supplement, since there is a body of thought that it reduces sensitivity to insulin. Others believe the opposite, so more studies might be needed in this aspect of the substance before it can be said to be safe for use by diabetics.
Over recent years, the American diet has increased significantly in its content of the undesirable linoleic acid, due to its ubiquitous presence in margarines, and has reduced in CLA due to modern farming methods. Cattle feeding techniques have resulting in a reduction of CLA in meat products and milk, although eggs are still a rich source, and the CLA in eggs can resist temperatures used in normal cooking methods such as frying, boiling, etc.
It is this CLA deficiency in the diet that has been proposed as one of the reasons for the current obesity problem in the USA. The European diet contains more beneficial fatty acids in general than the American diet.
However, there is an increasing body of evidence being accumulated that collectively that suggests almost unequivocally that CLA can help you lose body fat. Unless you are diabetic, there are few if any contra-indications and an increasing number of people are finding it effective not only to lose body fat, but to replace it with hard lean muscle.
May 09, 2008 11:09 AM
Colloidal trace minerals are just as important to our health and well being as vitamins. Practically since birth we have had it pounded into us that we must eat our vitamins if we are to be healthy. The fact is that vitamins are of little use to you without minerals which are as essential for your metabolism as any vitamin is.
The essential minerals are the inorganic equivalents of the essential organic vitamins. They work together to maintain the biochemistry that keeps you alive. Take calcium, for example. That is a mineral needed for healthy teeth and bones, among many other things, but it is no good without vitamin D. Magnesium and potassium are also needed for healthy bones. Take blood clotting: vitamin K is the blood clotting vitamin, but blood will not clot without calcium.
How is energy generated in your body from the carbohydrates and sugars that you eat? They are converted to glucose that is converted to energy in every cell in your body and used in-situ. Your heart gets the energy to beat from cells in the heart – energy does not float around the blood waiting to be used. It is generated by means of the production of a substance known as ATP – adenosine triphosphate of which phosphorus is an essential component. Without the mineral phosphate none of us would be alive – nor would any form of life for that matter. ATP is the universal molecule of life.
So far we have discussed some of the seven major minerals: calcium, magnesium, potassium, phosphorus, sulfur, sodium and chlorine. There are many more that your body needs, and estimates vary from 45 to 70 trace minerals, without which you would find it difficult to function properly. Although your body can make many of the organic substances needed for life from vitamins, amino acids, fatty acids and proteins, it cannot make minerals which have to be taken in as part of your diet. They must be taken in your regular diet or as a supplement.
In the USA a major mineral is one that is needed in amounts greater than 100 mg (0.1g) a day, and trace minerals are required at less than 100 mg a day. So one that is needed at 100.1 is major, and one at 99.9 mg is trace. Is there a difference in the source of trace minerals, or would any source be good enough? The answer lies in the construction of the human body, and the way in which it absorbs minerals.
Your body is not designed to absorb metallic minerals. The way that such minerals are available in your diet is as part of larger organic molecules, and this is the way they must be taken as a supplement. Thus, you can’t just drink a soluble metal salt because it will pass straight through you with only around 5% absorption, if it doesn’t poison you first. For supplement purpose, metallic minerals are chelated, or combined with larger organic molecules such as proteins and amino acids, and this increases absorption to as high as 50%.
The necessity of trace minerals in the human diet was not discovered, as much as the result of a number of studies on various societies and remedies that appeared to have no basis for their effects. The Hunzas and Azerbaijanis, for example, are known to live very long lives, and investigations into this showed their diet was very rich in colloidal trace minerals from glacial water and food grown in soil enriched by that water.
It was through studies such as this and also investigation into the metabolites obtained from liver extracts that indicated the importance of many trace minerals. Take arsenic, for example. A known poison in larger quantities, trace quantities have been found to be metabolized by the liver, and while no studies have been carried out on the use of arsenic as a trace element in human biochemistry, studies on rats and human liver extracts have indicated that it could have a part to play in normal growth and reproduction.
Trace minerals take part in many enzyme reactions, and physicians now agree that many health conditions could be enzymic in origin. It follows, then, that trace elements are important in maintaining good health. It is certainly true that we cannot live without any of the seven major minerals. And it is just as certain that many of the trace minerals are just as import to human biochemistry as the major ones. It is certainly true of vegetables, which are less complex biological entities than humans, and if tomatoes need at least eight known minerals for good growth then it is certain that we will need a lot more. No studies are needed to convince us of that.
Take zinc, for example. Zinc is essential for proper liver function, wound healing and reproduction: spermatogenesis, the proper development of the primary and secondary male sex organs, and all area of the female reproduction process. Zinc is classed as a trace element, as is selenium, a deficiency of which can lead to heart disease, mental retardation and impaired function of the thyroid. Selenium deficiency is not common in the West but is in China where many areas are depleted of selenium. However, if zinc and selenium are known to be essential, how many of the other seventy or so trace minerals are also essential to human health?
The trace minerals in general are believed to protect us from some degenerative conditions, the effects of environmental pollution and help to protect us from the effects of an excessive intake of toxic minerals. Although there have been insufficient studies carried out on most trace minerals, it is known that they should be taken in chelated form, metallic in nature or not.
It is also known that such minerals should be taken as a balanced mixture as found in nature. A bullet approach, using an individual mineral to treat a certain condition, could lead to an imbalance in the body, and severe side effects, some of which might not yet be known. What is known is that certain minerals are tolerated by each other in specific relative concentrations, but if this balance is upset then they can inter-react and produce unpleasant side effects on, for example, the delicate balance of minerals in the blood.
It is becoming increasingly clear that modern farming methods have resulted in mineral depletion of the soil, and that our normal diet now only contains a small number of the minerals that our forefathers were taking. Plants draw up minerals from the soil when they grow, and we take in these when we consume them or the animals that live on them. Saturation of the soil year in year out by chemical fertilizers low in or devoid of trace minerals has resulted in a sterile environment for our feedstock, and has made colloidal trace mineral supplements almost mandatory for good health.
Today’s plants can contain fewer than 20 minerals, compared to the 70 plus of our ancestors. Life expectancy is increasing in spite of our increasingly poor diet rather than because of it, and is due more to medical advances than to advances in agriculture. A mineral supplement does seem necessary, but when you take one it should be balanced so that no one mineral is in excess at the expense of another.
This helps to reduce the possibility of overdosing on an individual substance while maintaining a natural balance of minerals in your body to make sure that your normal biochemistry is not interrupted by some deficiency or excess that has yet to be discovered. While this might seem a spurious argument, you can be certain that those in the past that used cadmium and lead as cosmetics would rather have known the effects of these toxic substances that eventually killed them.
So use chelated trace mineral by all means, but make sure that they are balanced and tested so that nothing is present that can upset the normal balance of minerals in your body. If they work for tomatoes they should work for you!
Fat Controls our hunger centers in the brain!
April 04, 2008 11:28 AM
The main cause of any chronic disease of aging including Type II diabetes, CV disease, obesity, osteoporosis, and cancer are all caused by miss communication between signals that tell your body how to turn energy into life and the brain. The two most important signals that we know of today are given by the hormones insulin and leptin.
Leptin is an extremely powerful and influential hormone that is produced by fat cells. It has totally changed the way scientific researchers look at fat, nutrition, and metabolism in general. Before leptin’s discovery in 1994, fat was regarded as strictly an ugly energy store that most everyone was trying to get rid of. However, after it was discovered that leptin is actually produced by fat, fat became an endocrine organ similar to the ovaries, pancreas, and pituitary, as it influences the rest of the body, especially the brain.
Leptin is the most powerful regulator known to date of eating and reproduction. Your fat tells your brain whether you should be hungry or eat and make more fat, whether you should reproduce and make babies, or whether to maintain and repair yourself. It can then be stated that instead of your brain being in control of your body, your body, especially its fat and leptin, controls your brain.
Throughout history, it has been in ones best interest to store some fat to call upon during times of famine. However, it is also just as bad to be too fat. For most of our history, it was necessary to run, hunt, and avoid being prey. Therefore, fat storage had to be highly regulated and it still is. When a person typically tries to lose weight, the body tries to gain it back, resulting in what is commonly known as yo-yo dieting. Because of this, it has long been theorized that there is a “set point” and there must be a hormone that determines this.
Science now believes that leptin is that hormone. So in order to break the yo-yo cycle, one must control leptin. If a person is getting too fat, the extra fat produces more leptin that is suppose to tell the brain there is too much fat stored and the excess should be burned. Signals are then sent to the hypothalamus to stop being hungry, stop eating, stop storing fat, and start burning off some extra fat. Controlling hunger is a major way that leptin controls energy storage. Hunger is a very powerful drive that will make you do all you can to eat if it is stimulated long enough.
The only way to eat less in the long-term is to not be hungry and the only way to do this is to control the hormones that regulate hunger. The primary hormone that does this is leptin. It has recently been found that leptin not only changes brain chemistry, but can also rewire the neurons in areas of the brain that control hunger and metabolism to do its bidding. The inability of the body to hear leptin’s signals plays significant and even primary roles in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, cancer, and even the rate of aging itself.
In a process called glycation, glucose reacts with protein which results in sticky, sugar-damaged proteins called advanced glycated end products, or AGEs for short. When protein is damaged, it can’t function or communicate properly. AGEs promote excessive inflammation and free radical damage. AGEs and free radicals from oxidation are two of the major molecular mechanisms that cause damage which leads to aging. AGEs cause skin and the lining of arteries to wrinkle and inflame, which contributes to plaque and heart attacks. They can also promote the formation of cataracts and macular degeneration leading eventually to blindness.
The glycation process has also been connected with the destruction of proteins and nerve cells that may lead to Alzheimer’s disease, memory loss, and a variety of neuropathies. Glycation and oxidation are two of the major molecular mechanisms where damage accrues, disease occurs, and death results. High blood sugar can suppress your immune system, making you more vulnerable to infection and cancer. Highly aggressive cancers outpace the availability of oxygen and therefore must use an anaerobic fuel, in the form of glucose. By consuming glucose (sugar), we feed cancer. Lastly, high blood levels of sugar form non-fiber carbohydrates and excess protein send leptin and insulin levels upward.
If there is a known marker for long life, it is low insulin levels. Insulin’s purpose is not only to regulate blood sugar, but to store excess energy for future times of need. Insulin also lowers blood glucose levels as a side effect from storing it away, not regulating it. Today, high glucose is quite normal, as our insulin levels are typically much higher than they were among our ancestors. When you are constantly bombarding your cells with insulin, they become insulin resistant. This causes insulin levels to rise, creating a hormonal derangement that has a catastrophic effect on the metabolism.
High insulin contributes to making you fat because it tells your cells to store nutrients as fat rather than to burn it. Repeated high levels of insulin cause insulin resistance. The more fat the body accumulates the more leptin the body can produce so fat works against to slow down insulin production causing insulin resistance..
High insulin causes the retention of sodium, fluid retention, excretion of magnesium, elevated blood pressure, cognitive heart failure, blood clotting, and arterial plaque formation. Heart attacks are much more likely to happen after a meal that is high in carbohydrates than after one that is high in fat. This triggers a stress response which can cause arterial spasm, constriction of arteries, elevated blood pressure, irregular heartbeat and sudden death. Insulin resistance along with low magnesium keeps you from metabolizing important fatty acids that are vital to your heart health in general.
As critical as insulin is in your health, leptin may even be more so. Leptin plays a significant role in obesity, heart disease, osteoporosis, autoimmune diseases, inflammatory diseases, and cancer. But there are clues as to how to live a long and healthy life which brings us back to fat and leptin and our need to control it. One can control their insulin production and fat by dietary changes and blood sugar supplements.
Give Your Health A Boost With Silica Hydride A Powerful Antioxidant
January 18, 2008 05:25 PM
Hydride ions are strong proton acceptors and hence fatal to free radicals. Silica hydride is consequently a powerful antioxidant that can be used to protect your body against the ravaging effects of these free radicals that destroy the cells of your body, and due to its other unique properties this is a molecule that could be a very useful participant in the various redox reactions that occur naturally within our bodies every microsecond of every day of our lives.
A free radical is a positively charged molecule that is deficient in an electron. Whereas stable compounds consist of electron pairs, a free radical consists of electron pairs and one unpaired electron. Although such a compound is not stable, it does not immediately disintegrate but grabs the nearest electron it can find. This would normally be an electron in the nearest body cell to it, whether it is a blood cell, a cell in an artery wall or a skin cell. The result is that the cell that loses the electron is disrupted.
Free radicals are formed in the body through its normal biochemistry, and also promoted by pollutants such as cigarette smoke, pesticides and traffic fumes. Excessive exposure to the ultraviolet radiation of sunlight or sunbeds also creates free radicals, as does excessive exercise, believe it or not. As stated earlier, these chemicals have only one purpose in your body: to grab an electron from wherever they can, and in doing so they destroy the cells that make up your body tissue.
This can lead to premature aging, heart disease and many other problems with your health. Antioxidants such as vitamins C and E are important parts of your diet, and silica hydride is an other supplement which has been relatively recently discovered to have antioxidant properties. A component of glacial streams, this substance is generally in colloidal form, or in the form of small particles maintained in suspension by the interaction of positive and negative charges on the surface of the tiny particles of which it consists.
The interface between the silica and water can be saturated with reduced hydrogen to form a surface that is overall negatively charged and can hence neutralize free radicals that are seeking the free electrons available from the negative charge. This is otherwise described as a reducing or anti-oxidant effect. All anti-oxidants play their part in neutralizing the properties of free radicals that result in the destruction of body cells.
This leads to premature aging of your skin, if a skin cell is affected, if it is a cell in your artery wall, then the artery will become damaged, and if a blood cell then you can suffer from any one of a number of abnormal blood conditions. The stealing of an electron from one molecule by another is scientifically termed 'oxidation', and the substances that prevent this from occurring are called antioxidants, or reducing agents.
An antioxidant will destroy free radicals by providing the extra electron, or chemically, a negatively charged hydrogen ion. This occurs practically instantaneously, in microseconds in fact, as soon as the free radical is formed, so you need a good supply of antioxidants in your body at all times. Free radicals do not roam your bloodstream looking for likely candidate cells to destroy – they do it right away with the nearest available, so antioxidants must be present at the time that the free radicals are created.
Other beneficial effects of such antioxidants are an increase in the potential for the mitochondria to generate energy within your cells, an increase in the hydration of body cells and a decrease in lactic acid build–up that occurs as the result of exercise. The negative charges of silica hydride atoms are very strong antioxidants and can dramatically increase the energy production of mitochondria. It has been shown to do so by up to six times in Chinese hamsters. There is more on this claim for such a significant effect on your energy production later.
In addition to its action as an antioxidant, silica hydride is an electron donor to other antioxidants that have been neutralized by reaction with a free radical. When antioxidants do their work they are not destroyed, but neutralized. They act by giving an electron to the free radical, and are then one electron deficient themselves. This could virtually turn them into free radicals also were it not for the other electron donors available. Silica hydride is one of these. Thus, Coenzyme Q10, another very powerful antioxidant, can have is potency regenerated by silica hydride. If you take a silica hydride supplement, you are not only taking an effective antioxidant, but also a substance that can recharge the batteries of other powerful antioxidants.
Another side effect of this substance is that the reacted hydrogen atoms can also be used in the body to maintain a slightly alkaline pH which is an additional health benefit. pH is a measure of the acidity and alkalinity of the body fluids, and should be maintained slightly alkaline, other than in the stomach where the digestive juices are strongly acidic.
Silica hydride is not essential to the body, so you cannot suffer from a deficiency of it. It is not known to be contained in any foodstuff or water source, and appears to be available only as a supplement. Consequently no optimum dosage has been determined, though the supplements available contain from 200 to 250 mg per capsule. Likewise, side effects from it are unknown since there have been few scientific studies carried out on it. It has, however, been described as the ‘perfect antioxidant’.
Some of the claims made for the substance include reducing lactic acid concentration during exercise. Lactic acid production during exercise causes tiredness and cramps, and silica hydride is said to increase the body’s production of adenosine triphosphate (ATP) a substance essential for the production of energy in your body. This is through the reduction of nicotinamide adenine dinucleotide (NAD) to the reduced form NADH as a part of glycolysis and the citric acid cycle. Glycolysis is the metabolism of glucose to energy by the mitochondria.
If the claim that silica hydride effects this reduction of NAD to NADH six or seven times stronger than normal were true, then it would indeed be a significant energy booster invaluable to most athletes.
How to Manage Migraines Naturally: Magnesium - Feverfew - Butterbur - Ginger
December 21, 2007 10:41 AM
Before you can understand how to manage migraines naturally, it is necessary to understand exactly what they are and how certain treatments could work. It is not generally known that the word ‘migraine’ means ‘half the head’ because it frequently hurts only on the right or the left of the head of sufferer. Some people with migraines do feel pain on both sides at once, although this is not generally the case.
A migraine occurs in stages which are activated by fluctuations in the hormone content of the blood. The ‘aura’, when you see spots and flashing lights in front of your eyes, is the first stage of a migraine attack, and during this time the blood vessels in your neck and head are contracting. You could also find it difficult to concentrate and your fingers could feel cold. At this point they do not have the headache that starts when the blood vessels begin to dilate.
Rather than the contracted blood vessels slowly returning to normal, your hormones have an excessively strong reaction, and cause them to dilate rapidly and become much wider than they should be leading to a severe headache due to pressure on the nerves. Different hormones can be involves with each attack, and the range of effective natural treatments reflect this fact. During this period, your brain could swell slightly, your muscles can tense up and other things can happen to the chemical and hormonal balance of your body. That is why some herbal treatments work for some but not for others, and different people find different treatments effective for them. What works for you might not work for somebody else if their migraine has a different cause. Basically, though, migraines occur in two phases, one being associated with an excess of hormones and the other with a shortage.
It is not easy to live with a migraine since it can be completely debilitating. Some just have a severe headache, while others are affected for days at a time. The headache can become before and after the onset of the shimmering lights and other optical effects that are generated by the brain. It would certainly be useful if those prone to migraines had one or more of the possible natural remedies to hand since there is rarely time to seek to seek professional medical help once the migraine begins, and through the use of natural remedies a potentially bad attack could be nipped in the bud, and at least its effect on you reduced.
Magnesium is common in green leafy vegetables such as spinach and cabbage, whole grains, nuts and seeds. It is an essential mineral for human biochemistry, and is also needed with calcium for healthy bone development and maintenance.
Magnesium is a muscle relaxant, and relaxes the muscles of the blood vessels helping them to relax their dilatancy that cause the migraine pain. It is also useful to help the immune function, reduces blood pressure (by the same blood vessel relaxing mechanism) and also the rhythm of your heart. Magnesium therefore provides you with many health benefits, and though the western diet is not generally deficient in magnesium, some areas can be and a magnesium-containing supplement will not do you harm.
However, particularly high dose of magnesium can lead to nausea, diarrhea, low blood pressure and many other unpleasant side effects, so do not take more than the RDA (recommended daily allowance) in your supplement. Many studies have confirmed its effectiveness in reducing the symptoms of migraine, but not all studies have been successful. However, the condition is so debilitating to so many people, that it should be tried although not in excess. Make sure, however, that your doctor is informed since it could interfere with other medication you are taking for your migraine.
Riboflavin, vitamin B-2, is also believed to useful in reducing the duration and frequency of migraine attacks, working in much the same way as magnesium. It is known that there are many cases of people who suffer from vitamin B-2 deficiency also suffering from migraines, and a riboflavin supplement is also worth trying if you are a consistent victim of this condition.
Feverfew is the best known of the herbal remedies for migraine, and has been used for centuries in the treatment of fevers, headache, migraine and other painful conditions such as arthritis. The active ingredient is parthenolide, an anti-inflammatory that is also an anti-hyperalgesic, and that would explain its effect on reducing the pain. It also blocks lipolysaccharide-induced osteolysis by suppressing the activity of a eukaryotic transcription factor protein known as NF-kappaB that can cause a number of immune response problems, including inflammatory conditions such as arthritis, hence its use to relieve that condition.
Its effect on migraines could be explained by this activity in repressing the inflammatory response to certain stimuli that could be brought about by hormonal activity. Because it must be taken for a few weeks before the actual problem arises in order to be effective against it, feverfew is not effective to treat an existing attack, but to prevent future attacks. Double blind studies have proved its effectiveness in many tests, but not in all. However, if you take feverfew as a regular supplement in you diet, you might never have to try magnesium or vitamin B-2 supplements.
Some people swear by the leaves of feverfew, eating one per day which is easy way to take it. It is important, however, that you do so regularly, since it can take for up to 6 – 8 weeks for you to notice a reduction in your attacks. Don’t give up after 5 or 6 weeks, but continue, since the results will be well worth it. If you stop for a week or two you will have to start all over again. You might get a sore mouth and perhaps mouth ulcers to start with, but these will eventually go once your body is used to it.
You are probably best not to take if you are pregnant since it could cause you to abort. Otherwise, however, it has been shown to be effective in many severe cases. Feverfew is bitter, and can be used as a tea with other herbs, such as rosemary, lavender and sage. If you are taking warfarin, aspirin or other blood-thinning drugs, see your doctor first, and the same is true of NSAIDs (non-steroidal anti-inflammatory drugs). If you are taking these for arthritis, the feverfew itself might be more effective!
If you are taking feverfew as a supplement using commercially available dried leaf then the recommended dosage is around 125mg of the dried leaf. It should contain at least 0.2% of parthenolide (0.25mg/daily), although other studies have indicated that a total of 0.7 mg parthenolide a day should be taken (100mg at 0.7%). Parthenolide is unstable so don’t take it after its sell by or best by date.
Butterbur is also useful in the treatment of migraines. The active ingredient here is petasin, a sesquiterpene ester that also has anti-inflammatory properties, all though it works in a different manner to feverfew. Here, it inhibits the activities of leukotriene generation in neutrophils and eosinophils, which indicates that it also possesses anti-allergenic properties that could help asthmatics that also suffer from migraines. It does not prevent the release of histamine, but does appear to reduce smooth muscle spasm.
You should never take the raw herb, only the extract, because it contains alkaloids that can harm you. The butterbur extract, however, is a perfectly safe supplement and found effective by many people in the treatment of migraine.
If your migraine is at the front of the head, then you should try ginger. Unlike feverfew, ginger works on a migraine as it is occurring, and improvement can be achieved for a bad migraine within half an hour. In fact if, like many people, you can feel a migraine coming on, half a teaspoon of freshly ground ginger can stop the pain before it starts.
Many herbal treatments for migraine include a combination of some of the above remedies, and many people swear by them. However, migraine treatment is very personal, and you should use what works best for you. If you are also taking other medical treatments however, please make sure that you refer to your physician before using any others, and that includes herbal remedies or supplements.
Eggs: An Excellent Source of Omega-3 Oils for Better Health
December 18, 2007 11:43 AM
Eggs have many health benefits, among them being the fact they can be an excellent source of omega-3 oils that can promote better health in those that take it as a supplement. Hens fed on flax seeds are particularly high in omega-3 fatty acids, although eggs have many health benefits other than omega-3.
Most of the health benefits of Omega fatty acids are well known, although many more are being continually discovered as scientists research the uses to which the substances can be put in our bodies. Omega-3 fatty acids have long carbon chains that are polyunsaturated, i.e. contain multiple double bonds in the hydrocarbon chain. As opposed to saturated fatty acids with no double bonds. They are important components of our neurological systems and help to build up cell membranes, but are probably best known for their effect in protecting us from cardiovascular diseases. Omega-3 fatty acids can help us to maintain a healthy heart, and so enable us to live longer.
The current western diet has been changing to reduce cholesterol intake and improve our lifestyle. However, this has not all been well advised, and the resultant diet is rich in vegetable oils as opposite to animal fats, the relative levels of omega fatty acids having changed in favor of omega-6 fatty acids. These omega-6 fats are not as healthy for us as omega-3, and can lead to a thrombogenic state that more easily leads to cardiovascular diseases and blood clots. Rather than a normal omega-6 to omega-3 ratio of around 2:1, this ‘improved’ diet has increased it to anything up to 50:1.
The American Heart Association has been advocating a diet richer in omega-3 fatty acids since 1996, yet while research continues to favor omega-3, the increase in consumption of vegetable oils has continued to increase, and with it a reduction in the overall health of a nation.
Omega-3 enriched eggs have been introduced as one means of redressing the balance. Hens fed on flax seeds lay eggs with a much higher proportion of omega-3 fatty acids than normal: up to and over 150mg per egg. Such eggs also have reduced cholesterol – over 15% less, and also are higher in vitamin E, a strong antioxidant, by up to 300%.
Two of the components of omega-3 oils, linoleic acid and linolenic acid, are what are known as ‘essential’ fatty acids. The term means that they cannot be manufactured in your body, so must essentially be introduced through your diet. When the human body developed to what it is now, the consumption of fish and other oils rich in omega-3 fatty acids was a significant part of our diets, and allowed our bodies to develop the biochemistry and metabolism that it uses today.
If we now upset that biochemistry by cutting our intake of unsaturated fatty acids, our metabolism will suffer and our general health decline. This is one reason why humans should interfere with their natural eating habits as little as possible, or if we do so excessively we should use supplements to replace what we are excluding from diets that have been natural to us for countless millennia. It is dangerous now for the human race to suddenly switch to a significantly different diet without suitable supplementation, because we do not know the long terms effects of doing so.
One way to maintain a steady intake of the fatty acids our metabolism needs in order to ensure our survival is to eat eggs, and especially omega-3 enriched eggs. Of course, eggs have a lot more beneficial health effects than just omega-3. Take choline for example. This is a trimethylated compound that is important in the metabolism of fats. It is the newest official B vitamin, and is an essential component of cell membranes. It is particularly important for the maintenance of the health of your brain, and preventing many brain disorders.
It is also important in methylation, an important biochemical process, and also in the biochemical synthesis of the neurotransmitter acetylcholine. This substance is used to pass messages between nerve cells and from nerve cells to muscles, and a deficiency can cause many health problems, including heart disease and diseases of the vascular system. Methylation is a very important biochemical reaction, being used particularly in messages between body cells and is used to switch genes on and off.
Up to 90% of Americans are deficient in choline, and subject to many diseases because of it. Symptoms include insomnia, fatigue, excess fat concentrations in the blood and problems with your nerves and muscular control. It can cause liver problems and heart problems, and cause a number of brain disorders.
Choline is available in the diet from lecithin and egg yolks, and also soya beans, flax seeds, peanuts and potatoes. The typical American diet is not conducive to an adequate choline intake, and increased egg consumption can help to redress this. This is particularly true of eggs from hens fed with flax seeds, or linseed, from which the triple benefits of choline, omega-3 fatty acids and vitamin E are obtained. Just two eggs will provide you with almost 50% of your daily requirement of choline.
Some are wary about the cholesterol content of eggs, but studies have indicated that it not so much the amount of dietary cholesterol that is eaten, but saturated fats that cause the excess deposition of cholesterol in the arteries. Cholesterol is an essential part of human biochemistry, and without any we could not survive. In fact, studies have shown that eating two eggs daily can improve your cholesterol levels
Eggs are also rich in lutein, and contain more than vegetables such as spinach. Lutein is an important carotenoid that is believed to prevent age related macular degeneration, which can lead to blindness, and also prevents the development of cataracts. Eggs also appear to have anti-clotting properties on the blood, and so help to reduce the thrombogenesis of omega-6 fatty acids.
Without a doubt, eating eggs is very good for your health, and especially so if they are rich is omega-3 fatty acids. They contain a wide variety of nutrients and truly are a complete food packaged by nature. Some may prefer to stay away from eggs and miss the omega-3 benefits so there is an alternative for diets that exclude eggs. Omega-3 is available in a supplement form that one can take on a daily basis to reap the benefits omega-3 presents.
Are Vegan Supplements Good For Strict Vegetarians?
December 05, 2007 11:20 PM
The question as to whether or not vegan supplements are good for strict vegetarians cannot be answered or understood without a complete understanding of the meaning of the terms ‘vegan’ and ‘vegetarian’.
Where eating meat is concerned, there are several different types of diet, one extreme being the Atkins Diet where devouring animal flesh and fats is positively encouraged. However, it is not that extreme we are concerned with here, but the opposite, where no meat is eaten. Is there anything in a vegan diet that there is not in a vegetarian diet, or are vegan supplements harmful to strict vegetarians? These are questions that we shall now look at from a scientific viewpoint, since emotions are not involved in the answer to the question.
It is certainly true that for many people, emotions are very much involved in the distinction between an omnivore and vegetarian, and also between a vegetarian and a vegan. Some of these have to do with the concept of eating ‘friendly furry animals’ and others to do with the ethics of breeding animal life for the sole purpose of eating it. While these concepts have nothing whatsoever to do with the scientific arguments, they have a lot to do with the various types of eating habit used throughout the world.
Some reasons for a vegetarian diet are imposed by local agricultural and husbandry conditions, where meat is simply not available to most people, others due to religious beliefs and yet others to personal feelings of disgust at the moral arguments involved in eating animals that have been bred specifically for that reason. If we take carnivores and omnivores out of the equation, including those that do not eat red meats, but eat chicken and fish, what do we have?
Vegetarians that eat dairy products and eggs are referred to officially as lacto-ovo-vegetarians. The reasons for the name are obvious. They eat eggs, cheese and yoghurt and also drink milk. The strict vegetarians, on the other hand, who are part of the subject of this article, eat vegetables and dairy products such as yoghurt and cheese, but omit eggs. Then, finally, we have the vegans that eat only vegetable matter and no dairy products or animal based food at all. Each of these, you would think, would have a decreasing intake of nutrients essential for healthy and healthy growth.
A vegetarian diet, as opposed to that of a vegan, contains many nutritious foods that omnivores also eat, such as pulses (lentils, peas, beans), grains (wheat, oats), nuts, seeds and vegetable and fruits of any form. It can also include protein in the form of soy protein and tofu that can be formed into sausages, burgers and other meat-like products. Why vegetarians should want to make their foods look like meat is unknown, but that seems to what they prefer. The likely reason is that the majority of vegetarians and vegans became so after eating meat, and it helps them to stick to their diet by eating food in familiar forms.
Many have started their diets with what they know, and have substituted soy for minced beef in their spaghetti sauce, for example, and quorn for beef in their burgers. Together with a good piquant tomato sauce it is hard to tell the difference. Other than truly meaty dishes such as steaks, then, most meat dishes can be substituted for vegetarian alternatives or substitutes.
However, what does this do to the vegetarian’s nutrition? How does the vegetarian maintain a sufficient intake of minerals, vitamins and other nutrients by eliminating meat from their diet? Let’s have a look at some of the nutritional content of fish and meat that vegetarians are apparently not getting.
The first is protein, the main source for most people being from the flesh of meat and fish. Protein is essential for the maintenance of healthy muscles, vital organs, skin, and believe it or not, bones. A vegetarian eating eggs has no problems with protein, since eggs and cheese are full of it. There is also the protein in soy based foods and in quorn, a mycoprotein derivative of fungi. Nuts, peas, beans, cereal grains and seeds are all rich in proteins and the vegetarian does not have a problem in consuming an adequate supply of protein.
If we come to minerals, the most important for the health of your blood is iron. Green vegetables and whole grains are good sources of iron, as are pulses and some fruits. However, it is animal sources of iron that the body most easily absorbs, and in order for it to make use of vegetable sources, you should consume a good intake of vitamin C by eating plenty of fruits and green vegetables. You must take these at the same time as the vegetables that contain iron, or the iron will not be absorbed into the body. Otherwise, the vegetarian has a sufficient iron intake to maintain the health of their red blood cells.
The other critical mineral is calcium, essential for healthy bones and teeth. Many dark green vegetables are good sources of calcium, as are turnips, swedes and fortified soy milk. Zinc, too, is essential and without it many enzymes could not be synthesized by your biochemistry, and it is also necessary in the male reproductive system. Zinc, too, has many vegetarian sources, such as nuts, wheat germ and whole grains, and is also contained in soy.
So far in this evaluation neither vegetarians nor vegans have been seriously compromised by their diet, although there are arguments that a vegetarian diet can harm young children since there is insufficient protein available to allow normal growth and development. This is currently under debate, and it is a matter for parents to consider whether or not their children should be raised on a purely vegetarian diet.
However, when it comes to a vital vitamin that is necessary for the production of red blood cells and the prevention of anemia, vegans become unstuck. Vitamin B-12 is found predominantly in dairy products and other animal products. It is claimed that cereals enriched with B-12 and fortified soy products provide this vitamin to vegans, but what are the sources of the vitamin that is used as a supplement?
It is generally accepted that vegans require vitamin B-12 supplements, and also others such as calcium that they might be deficient in due to their diet. It is possible that the only real supplement needed is vitamin B-12, although many nutritionists claim that both vegetarians and vegans should take supplements to boost intake of those nutrients of which the normal route to the body is through eating foods of animal origin.
There are many nutrients obtainable from animal sources that are classed as neither vitamins nor minerals, and for which there are adequate supplements to suit the needs of vegans and vegetarians alike. Further evidence is needed, however, that vegans are deficient in these since many of them have alternatives of vegetable origin that might annul their necessity.
One thing, however, is absolutely certain, and that is the answer to the original question. It is absolutely true that vegan supplements are good for strict vegetarians. The reason for this is that vegan supplements are designed to replace not only nutrients that the body might be deficient in due to a strict vegetarian diet, but also those missing by the absence of dairy products such as milk, cheese and yoghurt.
Vegetarians will also benefit from such supplements, and it could be important to their health that both vegetarians and vegans take them.
7-Keto, The Next Dhea With No Side Effects
November 10, 2007 12:24 PM
7-Keto is a natural derivative of DHEA that is claimed to be free from many of the side-effects of regular DHEA supplements. DHEA is dehydroepiandosterone, which is the most abundantly produced of the adrenal hormones. After production in and release into the bloodstream by the adrenal glands that are situated just over the kidneys, DHEA undergoes metabolism to the male androgen hormones, and the female estrogens.
As you age, the production DHEA declines, starting at about 30, with a 50% decline by time you reach 40 and almost 85% at 70. This is true of the levels of many hormones in the body, though some, like the steroidal aldosterone, remain constant throughout life. The general rate of metabolism also reduces with age resulting in an even lower conversion rate of DHEA to the male and female hormones.
At the same time as this occurs, there also occurs a significant reduction in the biosynthesis of protein in the body, which results in a loss of muscle mass as you age, and also in the regeneration of bone tissue that results in what is commonly termed age-related osteoporosis. Brain cells die at an increasing rate leading to many neurological conditions and the immune system is also affected negatively.
Due to the concurrence of these aging effects, many scientists have related the general hormonal decline with the other effects of aging. The have asserted that if these hormones were restored, than many of the effects of aging could be delayed. Osteoporosis would be delayed due to the body’ s increased ability to restore lost bone mass, the metabolic rate would improve and fat would be burned at a faster rate and continue to build muscle, the brain would lose its functionality at a significantly lower rate and the immune system would continue to protect the body against disease.
In other words we might be able to live longer, but if not that then at least the quality of life would be maintained longer as we aged. This is a very welcome and desirable situation, but the taking of hormones as supplements has long been regarded as fraught with danger due to the possibility of undesirable side effects, some of them potentially very serious. DHEA was considered as one of these hormones that could be used as a supplement to achieve positive results in reducing these age-related changes because it exhibited these effects in tests on animals.
However, in order that a specific substance can be declared responsible for any metabolic improvement that involves liver biochemistry, some form of receptor has to be identified, and this failed to materialize in DHEA. There appears to be no such DHEA receptor, although that does not necessarily imply that DHEA is not responsible in some way. It might very well be a DHEA metabolite that is responsible, and that has still to be identified. It is certainly true that DHEA administered to both animal and human subjects has resulted in an increase in the testosterone and estrogen levels of the subjects. Such an increase is not desirable due to a number of potential side effects as previously inferred.
These are particularly liable to occur with people who already have an adequate level of natural DHEA production within their body. The side effects include acne, irregularity in the menstrual cycle, itchy scalp, increased body odor and an excess of androgenic hormones can lead to hair loss, or male pattern baldness. Interruptions in the heart rhythm, or palpitations, are another very serious side effect of DHEA supplementation, and high doses over a long period introduce a theoretical risk of certain cancers.
However, the discovery of 7-Keto, a natural derivative of DHEA claimed to be free from many of these side effects, has altered the situation. 7-Keto is a powerful antioxidant that speeds up the metabolism of fat and helps to reduce body weight. It also helps to replace lost fat with muscle mass, though it must be stated that this effect is only valid after the natural production of DHEA has slowed down. It is not a body-building supplement.
It was Professor Henry Lardy, of the Department of Biochemistry at the University of Wisconsin, who tested over 150 DHEA metabolites over 10 years and identified 7-oxo-dehydroepiandrosterone as having the greatest biochemical effect without having any detectable side effects. This material was trademarked 7-KETO by the Humanetics Corporation, and one of its known effects is to burn fat quicker by stimulating thermogenesis. It had also been shown to strengthen the immune system and to improve the memory. All of this without any measurable increase in any of the sex hormones. It was released after a careful and intensive series of safety tests on both humans and animals found it safe for human consumption.
It should be stressed that 7-Keto is not a hormone, and is not chemically the same as DHEA: it is a different chemical altogether that is produce when DHEA degrades in the body. Because of this it can be promoted as a non-androgenic or estrogenic form of DHEA. It is thought that all of the conditions that decline as we age that can benefit from a supplement of DHEA, will also benefit from a supplement of 7-Keto. However supplementation is only required from the ages of 25 – 30, when the natural amount of DHEA and 7-Keto in the body start to decline.
It causes neither high blood pressure nor any form of cancer, and was submitted to the FDA prior to being made publicly available. It is important to stress that the substance is neither a steroid nor does it metabolize to steroidal hormones, and is also not a sex hormone. It also has no effect on the body’s sex hormones. The whole point of 7-Keto is that it has the effect of DHEA without having any connection whatsoever with steroidal hormones or any hormonal substances. It is totally innocuous and safe to use, without the risk of heart palpitations, lost hair or any of the other side effects of DHEA.
Without a doubt, 7-Keto is a DHEA substitute that has none of the side effects of its precursor. So if you are over the age of 30 and feel the need for an energy boost, give 7-keto a try.
Increase Absorption Of Your Discount Vitamins With Bioperine
November 02, 2007 04:54 PM
In order to understand how you increase absorption of your discount vitamins with Bioperine, it is necessary to understand the metabolic process of thermogenesis. First, however, let’s have a look at what Bioperine is and where it comes from.
Bioperine is obtained from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) of which it is a patented standardized extract. These peppers contain the alkaloid piperine, and the extract contains 95% piperine. The plants are grown in the ideal damp soil in regions of Southern India where the earth is rich in nutrients. The barriers are harvested just before ripening, and then dried in the hot sun before the extraction process is started. Piperine has many uses from flavoring to fly killer, but people have been using it for centuries to heal wounds though this is apparently unconnected with the use to which the extract is put.
It has recently been found to help increase the absorption of a number of discount vitamins and minerals, including Vitamin B, beta-carotene, and selenium, by increasing the thermogenic activity of the body. Thermogenesis is one of the metabolic processes of the body that takes place within our cells whereby glucose is converted to energy, but at an accelerated metabolic rate. It is the rise in the metabolic rate that is referred to as thermogenesis.
When you eat food, or take supplements, the metabolism increases above the normal rate, the amount of increase depending upon the type on nutrient taken. Fats will increase your metabolism at a lower rate than proteins will, for example, since more energy is needed to break down proteins than for fats. Another substance that stimulates thermogenesis is piperine. It does so by utilizing the biochemistry of the body so that the chemicals needed for thermogenesis are made available.
Piperine triggers the release of compounds known as catecholamines, hormones that in turn stimulate the thermogenetic process. However, this occurs over a short period of time, so the nutrients that are needed should be present in the gut as well since the window of absorption is very narrow. The substance also modifies the epithelial cell wall of the intestine to make it easier for the nutrients to be absorbed into the bloodstream, and it also gives amino acids a kick to get moving to the cells in which they are required.
Bioperine, then, not only sets off the metabolic changes that demand vitamins and other nutrients and enzymes, but also improves the conditions in your intestines so that these nutrients can more easily get to where they are needed. Basically, what Bioperine does is to cause the intestinal wall to become more permeable to nutrients, so that vitamins and drugs are not degraded when passing through the intestinal wall to the bloodstream. This improves digestion and absorption of minerals and vitamins, in addition to protein supplements frequently used in weight loss diets.
Bioperine starts by generating a need for nutrition and then increase the bioavailability of the nutrients provided to meet that need. However, due to the short window of absorption that piperine generates, the vitamins and minerals you want absorbed should be co-administered with the Bioperine so that they are in place ready to be absorbed at exactly the right time.
There have been several studies carried on the efficiency with which piperine achieves this. The absorption of three different types of nutrients has been measured with and without Bioperine. These were beta-carotene, a fat soluble vitamin, vitamin B-6, a water soluble vitamin, and also a mineral, selenium which was provided as selenomethionine. The absorption of these by the digestive system was measured by detecting them before and after in the blood, and were found to increase considerably when taken along with Bioperine, but not so with the control group without it.
Measured increases were a 60% increase in beta-carotene, similar to that of vitamin B-6, and was 30% in selenium. The tests used a 5 mg dose of the Bioperine. Other studies have indicated an increase in the absorption of Coenzyme Q-10 of between 30% - 200%. This is the only piperine based product that has been patented for its effect in increasing the absorption of nutrients into the body, and also the only piperine based product to undergo such tests in the U.S. to substantiate its claims and prove its safety for use.
The black pepper itself is a common household spice, and has been used in India for its medicinal properties for centuries. It is mentioned in the practice of Ayurveda and its concentration on the function of the digestive tract in human health. Many of its formulas contain black pepper amongst their ingredients. The bioavailability of nutrients is a significant factor in the health of any specific population, and the exponents of Ayurveda overcame this problem, by chance or design, six millennia ago. It has been demonstrated time and time again that diet is not the factor of importance in nutrition, but how much of that diet is absorbed through the intestines.
This is yet another example of the medicines of our ancestors being shown to have a solid scientific basis, and perhaps we should pay more attention to those others that are disregarded by modern science. It could be that we have only scratched the surface of understanding human metabolism and biochemistry, and that there is much left to learn. Ancient wisdom should never be disregarded.
Bioperine is also available in many supplement mixtures so that it is taken at the same time as the relevant vitamins and minerals. The recommended dosage is from 1 mg – 5 mg from 2 – 3 times daily. It takes around 2 – 5 mg of Bioperine to provide sufficient enhancement of absorption of the nutrients that are taken with it. Keep in mind that the nutrients are best taken at the same time, and that taking the extract itself will simple increase the absorption of any nutrients that are in the intestine at that time. Bioperine can be purchased at your local or internet vitamin store.
October 24, 2007 11:37 AM
Ubiquinol has powerful antioxidant actions in target cells *
Although ubiquinone (oxidized coenzyme Q10) and ubiquinol (reduced coenzyme Q10) are kept at a constant ratio within the body, the majority of the total coenzyme Q10 pool is made up of ubiquinol. In fact, when ubiquinone is taken orally, much of it appears to be rapidly converted into ubiquinol. 1,4 Ubiquinol functions as a potent antioxidant in humans, including in low-density lipoproteins (LDLs) where it protects them from oxidative damage.1,4,5 The coenzyme Q10 molecule can be found in all membranes throughout cells.6 It appears to works in conjunction with both vitamin E and vitamin C to provide antioxidant actions throughout the body.7
Coenzyme Q10 supports mitochondria to enhance cellular energy production*
Coenzyme Q10, with its widespread distribution throughout the body, plays a crucial role in mitochondrial physiology as a critical member of the electron transport chain. This transport chain, which is part of cellular respiration, leads to the formation of adenosine triphosphate (ATP), our body’s primary energy source. Levels of this key nutrient may decline as a healthy person ages.7,8 Animal studies have found that supplementation can restore normal levels in certain tissues 6, and human studies suggest that supplementing with this enzyme may have increased benefits when a person has depleted levels. 7
Coenzyme Q10 supports healthy heart functioning*
Concentrations of coenzyme Q10 are understandably high in the heart as these muscle cells require high levels of energy to constantly function optimally. A number of studies (both animal and human) strongly suggest that coenzyme Q10 supplementation is supportive for healthy heart functioning and for maintaining cardiovascular system health.7,9
Ubiquinol has been studied for safety and bioavailability in humans*
A recently published single-blind placebo-controlled study in healthy subjects found no safety concerns in people who took Kaneka’s QH ubiquinol supplement orally at doses of up to 300 milligrams daily for up to four weeks.4 Single oral doses of either 150 milligrams or 300 milligrams were given to fifteen healthy men and women, and standard laboratory testing (including hematology, blood chemistry, and urinalysis) as well as physical examination and electrocariography (EKG) results showed no clinically significant changes when tested two days after supplementation as compared to before the taking the supplement. In addition to the single dose study, 80 healthy volunteers were given either placebo, 90, 150 or 300 milligrams of ubiquinol each day for four weeks, and again no clinically significant differences were seen in any of the testing parameters after two and four weeks of supplementation, nor were there differences two weeks after discontinuation of the supplement. By monitoring levels in the blood, the authors found that ubiquinol was well absorbed.4
Studies in several animals also reveal no concern of toxicity in doses of ubiquinol up to 200 milligrams per kilogram of body weight for up to thirteen weeks.4 When compared to humans, this dose level is enormously higher than the recommended doses. Supplementation with ubiquinol appeared to be safe at even higher levels (up to 600 milligrams per kilogram body weight) in a study using a different animal. In vitro assays additionally found no safety concerns for the use of ubiquinol, as it was found to be non-mutagenic and did not cause damage to chromosomes in cells.
Suggested Adult Use: Take one softgel daily with food, or as directed by a nutritionally informed physician.
1. Mohr, D., V.W. Bowry, and R. Stocker, Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta, 1992. 1126(3): p. 247-54.
2. Weber, C., et al., Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol Aspects Med, 1994. 15 Suppl: p. s97-102.
3. Okamoto, T., et al., Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vitam Nutr Res, 1989. 59(3): p. 288-92.
4. Hosoe, K., et al., Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol, 2007. 47(1): p. 19-28.
5. Stocker, R., V.W. Bowry, and B. Frei, Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A, 1991. 88(5): p. 1646-50.
6. Crane, F.L., Biochemical functions of Coenzyme Q10. Journal of the
7. Jones, K., et al., Coenzyme Q-10 and cardiovascular health. Alternative therapies, 2004. 10(1): p. 22-31.
8. Schulz, C., et al., Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10). Int J Food Sci Nutr, 2006. 57(7-8): p. 546-55.
9. Coenzyme Q10. Monograph. Altern Med Rev, 2007. 12(2): p. 159-68.
Buy Ubiquinol at VitaNet, LLC ®
Staying Healthy Means Keeping Your Blood In The Proper PH
October 21, 2007 07:04 PM
The blood should be electrolytically neutral, or very slightly alkaline. The proper pH for blood should be 7 or just above it, and many claim that it should be 7.35. In fact the truth is that your blood pH should be between 7.2 and 7.6. Outside these limits and you could have serious health problems, with your brain particularly being affected.
For those who have forgotten their school chemistry, pH is a measurement of the level of acidity or alkalinity of an aqueous solution. Anything over 7 is said to be alkaline, and below 7 is acidic. Where the pH has to be maintained at a certain level, a material called a buffer is used that counteracts the effects of other acids and alkalis to maintain the desired pH range. Buffers are very common in nature, as would be expected of life forms that depend upon water and aqueous solutions for their survival. Blood is an aqueous solution containing plasma, blood cells, nutrients and various other ingredients in both solution and dispersed solid form.
The human body possesses a very effective pH maintenance system that depends on various buffers, the kidneys and the lungs. Lets have a closer look at buffers and how they work. pH is, in fact, a measurement of the concentration of hydrogen ions (H+) in a solution. The way a buffer works is to absorb or release H+ ions to keep the hydrogen ion concentration at a specific level. If there are too many H+ ions present in the blood, and it becomes too acidic, then the buffer will mop up the excess. If there are too few, and the blood becomes too alkaline, then the buffer will release more hydrogen ions into the blood. In this way the pH is maintained at the limits mentioned above.
Buffers in the human body include some forms of protein, phosphates and also hemoglobin. However, if the pH variations are more than just occasional, the buffers have a limited capability, and a more permanent solution is needed. If the blood is continually becoming too acidic, the bicarbonate ion is used to clear them up. Just as bicarbonate of soda is used to clear up excess acidity in your stomach that causes indigestion, so it can be used to clear up excess acidity in the blood. But how do we get the bicarbonate into the blood?
When the lungs inhale oxygen, they then exhale carbon dioxide. The bicarbonate ion, also called the hydrogen carbonate ion, is formed in the blood by dissolved carbon dioxide. The faster we breathe the more carbon dioxide we exhale and the less is left in the blood to form bicarbonate. The slower we breathe, the more carbon dioxide is available in the blood for bicarbonate. Thus, when our blood acidity increases we breathe slower, and when it decreases we breathe faster since less carbon dioxide is needed in the blood to form bicarbonate to neutralize the acid.
The kidneys also help to regulate the pH of the blood, although the biochemistry involved is fairly complex, and will not be covered here. It is enough to state that the body has a number of routes by which it can control the pH of the blood.
Current thinking is that alkaline and acidic foods should be balanced in your diet in order to place less of a strain on the body’s pH control systems. Since the blood pH must be slightly alkaline, then it might make sense to eat a slightly alkaline diet. However, it is not the actual food that matters, but what happens when the food is digested. Hence, orange juice is classed as an alkaline food even though it is high in citric acid and itself has a low pH. The same is true of lemons. They taste very sour, yet the result after digestion is alkaline. It is the end result that counts. After all, the stomach acid is very strong and very highly acidic, and eating slightly alkaline foods is not going to alter that. The digestive juices have to be highly acidic to break down the organic matter.
It had been calculated that a mix of around d 75% alkaline and 25% acidic food is a good combination of the two types to provide approximately the desired blood pH. Among the common acidic foods are meat, fish, poultry, plums, grains, eggs, wine, cheese and offal. The alkaline foods are most fruits and vegetables, orange and lemon juice, melons, potatoes and chocolate. Hence, it is possible to eat beef and chicken, and have the odd glass of wine so long as we eat plenty of fresh fruit and vegetables. There is nothing at all unusual with that diet, and it underlines the importance of eating a healthy balanced diet. While more greens and whole foods are definitely healthier for you, you should not eat exclusively an alkaline diet.
If your blood pH is on the high side of the limit, then you can eat a bit more meat or fish, and if on the low side eat a more vegetarian style diet. It is important, however, that you eat healthily, irrespective of whether you are eating alkaline or acidic foods. Through history, the human race has adopted a more acidic diet than the ancient hunter gatherers. Grains are a relatively recent invention, introduced after the invention of stone tools to mill them, and dairy products are also relatively recent in terms of the whole of human history. Even the consumption of meat only began after mankind learned first how to trap and then developed tools to enable them to kill their prey.
Human biochemistry, then, has developed from a predominantly vegetarian diet. However, protein is still very important, and while protein intake is necessary, should comprise no more than 20% - 25% of your total food intake. The rest should comprise of mainly fruits and vegetables, with whole rather than refined or processes foods predominating. Sugar was not eaten in quantity until the industrial revolution.
Measuring the pH of your blood is easy to do. It is simply a matter of using pH paper strips and checking the color change with your blood. They are available at most pharmacies and health food stores. If your pH level varies from 7.4 or 7.5, then you should change your diet accordingly. Higher than this, then eat more acidic foods, and if lower you should eat more alkaline food. It is simple equation, and the changes you will have to make to your diet will be minimal. Some of these changes can be made by the use of supplements that are carefully balanced to maintain your blood in the proper pH.
Omnivore Vs Vegan Who Is Right?
October 21, 2007 07:02 PM
The omnivore vs vegan argument as to who is right and who is wrong can be argued from a number of different platforms. There is the ethical issue of whether we should eat other animal life, and also the argument as which is ‘better for you’, based on arguments such as vitamin B12 is not available from a vegan diet. There is even the ‘lifestyle’ argument: does our lifestyle define our diet?
However, strictly, the only argument for or against either diet should only be made upon human biochemistry. Do both meet the needs of our biochemistry, or does one or the other lack something essential in our biochemical pathways? Obviously omnivores will lack nothing except by choice, since all foods are available for their consumption. If vegans do lack a specific chemical need, then is that available as a supplement in a form that can be effectively used in the chemistry of our bodies.
The one argument accepted by both sides is that it is essential for all animals to consume living things in order to stay alive themselves. These living thinks need not be alive at the time of consumption, but it is necessary that they eat the flesh of plant or animal life that at one time was alive and contained DNA. What that infers is that it is only vegetables that can survive on non-living tissue and this appears to be borne out in practice. No living animal known can live on inorganic matter only, but most plants can and do. Not all though, the Venus fly trap being an example.
It is easy to extend the moral problem of eating living tissue to living vegetable tissue that also contains DNA, and the argument must lie between animal and the derivatives of animals, and non-animal tissue. It has not yet been found that any organism has yet crossed the animal-vegetable divide, so the division is a valid one. That might seem obvious, but it is necessary to establish that for the argument between vegan and omnivore diets to be valid.
The consumption of protein derived from meat is not a prerequisite for size and muscle bulk, since the largest dinosaurs in the world were all herbivores, the largest being a member of the sauropod family at more than 175 tons, eclipsing the largest meat eater, the gigantosaurus at 8 tons. Thus, meat does not mean bulk. However, what has been proved is that the fastest creatures are carnivores. Hence if you want to be a top class sprinter, eat meat!
Carnivores, with their lean muscle mass and highly efficient quick use of available energy, have very short digestive tracts which are not good for digesting vegetable matter, but make best use of animal proteins and expel unnecessary mass from the body quicker. The argument in favor of the vegans is that the human digestive tract is not that of a carnivore.
In herbivores, the food takes longer to digest, and hence it remains in the digestive system longer. This means a longer alimentary canal, longer than humans have. Herbivores also move slowly, and a good example is the comparison of speed between the omnivorous chimpanzees and other small monkeys and the herbivorous gorillas and orangutans. On the one hand you have lean fast moving machines, while on the other you have large bellies and slow moving larger animals. Check out cows and sheep and compare their body fat with ours. Nor are we like herbivores.
So what are humans? Omnivores! Our teeth and intestines are those of omnivores, the teeth designed for ripping and tearing meat, and stripping leaves from trees, but also for grinding grains, and our intestines are something between the long and the short. People are able to eat and live on every type of food imaginable from brains to intestines to leaves to roots to ants and grubs.
The argument is therefore futile to consider historically. Let’s then study the advantages and disadvantages of each type of diet. Human beings are capable of life through consuming either animals or plants, or both. The argument seems, therefore, to be one of morality rather than biochemistry. However, is that really so? The vegan refusal to eat dairy products should not be taken as extremism, since the human being is the only animal species to drink milk of another species, or to use it to make other products. It is a practice born long after cattle were husbanded by humans for food. The problem with eating animal products lies not in the meat itself, but in the fat. Animal fat is saturated, which means that the fat molecule has no active double bonds in the chemical structure that can be used to break the fat down.
Animal fat also contains cholesterol, yet we cannot survive without cholesterol. It is the human band aid, used by the body to patch up damage to the cardiovascular system. Only, sometimes, too much is laid down and the arteries get blocked. However, many vegetable products have more saturated fats and cholesterol than many animal products, so a balance is called for. The unsaturated fats and oils for humans are said to be derived from seeds, such as flax seed and fish, especially oily fish. These are the Omega-3 oils. Although they can be obtained from some seeds and nuts, it has been proved that the best come from oily fish, such as wild salmon, mackerel and sardines.
The B vitamins are essential for life. The best sources are animal sources, though you get them from some vegetable sources such as brewers years (who eats lost of that?) and others, but animal sources are the best.
Also, there is no evidence to suggest that vegans live longer than omnivores. In fact all of the evidence indicates that a middle road is the best. For human beings the healthiest diet includes both meat and vegetable tissue. The best solution to good health is neither vegan nor carnivore. Nor is it traditional vegetarian, since it is the dairy products that cause many of our dietary products.
Studies of the biochemical pathways have demonstrated that all chemicals need to sustain healthy human growth and life are not available from a classic vegan diet. Some animal protein and B vitamins are essential that cannot be obtained form a normal vegan diet. It is possible, however, to maintain life by means of supplements.
However, for the healthiest form of human life, our biochemistry, history and physiology indicate that there is a balance somewhere between the extremes of both views that is right for us, and that either diet can be sustained with appropriate supplementation based upon what is missing from one diet or the other.
So, omnivore vs vegan. Who is right: both are right if they also supplement any nutritional deficiencies in their diet with vitamins and minerals that may be lacking from one diet or the other.
The Important Role of Nutritional Magnesium & Calcium Balance in Humans Living with Stress
August 23, 2006 03:14 PM
Part I. The Stress Response
The stress reaction is a host of responses necessary for any animal to live in the world. Commonly called the fight-or-flight reation, we as humans often experience it in rapid heartbeat and increased breathing rate. It comes when we exercise more vigorously than usual, or when we are suddenly and unexpectedly frightened.
We are all different. We show a range in how strongly we experience the stress response. Most of us are usually calm and experience the stress response when an unexpected noise frightens us to alertness, or we run to first base as fast as we can in a benefit baseball game that is not on our usual playtime schedule. We breathe harder for a while and notice our hearts beating faster and harder then usual, but after a while these responses all calm down, and we are again in our usual state—out or the stress response. Others of us are very low key, and it takes a lot to disturb our physiological calm. Still others of us are very sensitive to triggers of the stress response and go into it “at the drop of a hat” and to a greater degree than do calmer people. For some, parts of the stress response are almost always engaged—never really calming down all the way—giving one a hyper-vigilant or anxious demeanor.
When a stress trigger occurs, the body puts out stress hormones, magnesium and calcium, among other things, into the bloodstream. At the same time, nerve cells begin to “fire,” telling heart and muscles to “speed up. NOW!!!” These blood, nerve and organ changes make possible the instantaneous and collective rise in the body’s heart rate, blood pressure, and other necessities for the fight-or-flight reaction.
Much research has been done on the stress response, especially on the effects of stress hormones, such as adrenaline (also called epinephrine) on body, organ and cell. You can get an idea of how widespread the stress response is-affecting every aspect of physiology—by noting some of the reactions to adrenaline, one of the major stress hormones. See Table 1.
Much study as the cellular, biochemical and physiological levels has shown that the stress response vitally involves the influx of calcium into cells, resulting in a drastic change in the cells’ internal magnesium-to-calcium ratio (Mg:Ca).
In simple solutions, such as salt water, all ions are evenly dispersed. Not so in living cells. Ions are carefully and meticulously separated in living cells, and this ion “packaging” is vital to life processes and health. Calcium ions, for the most part, are kept outside cells while magnesium ions are kept mainly inside cells. The stress response changes this. During stress response, calcium ions rush inside the cell, and this alters the internal Mg:Ca ratio. This change in ratio exhibits wide effects because, while magnesium and calcium are very similar in their chemistry, biologically these two elements function and react very differently. Magnesium and calcium are two sides of a physiological coin: they are antagonistic to one another yet comes as a team. For example:
Scientific study shows more and more that the underlying cellular change enabling the stress response is a low Mg:Ca ratio caused by a large and sudden influx of calcium into cells. This stress response subsides when the cell’s magnesium returns to its dominant presence inside cells, moving extra calcium back outside cells to its “normal” Mg:Ca ratio. This underlying principle is present in studies of nerve cell-stress hormone response, organs such as hearts, the high blood pressure response to stress, and the blood-clotting reaction during stress, among many others. See Table 2.
In the normal healthy state, the stress response occurs when necessary, and subsides when the crisis or trigger is over. Since magnesium and calcium—two essential nutrients that must be obtained by the body from its dietary environment—are so essential to this important response, it is not surprising that nutritional magnesium and calcium status can affect the response.
Let’s see how.
In the normal unstressed state, cellular Mg:Ca ratio is high. If this cannot be maintained due to lack of adequate body magnesium or an overwhelming amount of body calcium, the ratio may not be able to maintain or return itself to its healthy nonstressed ratio. In such a case, the stress response, in the absence of an appropriate trigger, can occur. This can be seen when nutritional magnesium deficits cause high blood pressure or increase blood stickiness (platelet aggregation). Additionally, since a low Mg:Ca ratio can increase adrenaline secretion as well as cells’ response to adrenaline, a too low magnesium state can keep the stress response from subsiding in a timely way. Even worse, when body magnesium becomes drastically low, this becomes a stress trigger in itself, alarming the body into further stress response with out enough magnesium to back it up, resulting in a low magnesium-high stress crisis that can end in sudden death.
In the industrialized world, we live in a state of chronic, on-going stress. This environmental reality increases our daily need for magnesium in order to maintain a healthy stress response that can calm when not necessary.
Part II. Heart Disease Is Often a Magnesium Deficiency
Clearly, an adequate amount of nutritional magnesium—in proper balance with adequate nutritional calcium—is key to a healthy stress response. And yet today we have diets dangerously low in magnesium. Add the recent additions of nutritional calcium via supplements and food fortifications meant to stave off osteoporosis, and many of us are getting inadequate magnesium plus too much calcium. This results in a large occurrence of heart disease.
Not all, but much of the heart disease in the industrialized world can be explained by the low magnesium state of these societies. People with heart disease—for the most part—are people who are in a state of magnesium that is borderline or deficient. Many studies on heart disease patients exist due to medicine’s effort to understand and treat this widespread malady. Although not intended as such, this body of research shows us what stress can do to a person in a magnesium deficient state.
Part III. Mental and Emotional Stress Deplete Magnesium
It is commonly accepted that certain traditional risk factors for heart disease exist. This include high cholesterol, high blood pressure, family history of heart disease, and other factors, all of which can be linked to a shortage of nutritional magnesium. Recent studies tell us that stresses—both sudden and chronic—with their high magnesium requirements, are also strong risk factors for heart disease.
The sudden stress of the
Emotional stress and phobic anxiety cause heart problems in patients with heart disease—a population we know to be mostly low in their nutritional magnesium status. Chronic states of emotional stress, including a history of childhood abuse, neglect or family dysfunction, depression, and panic disorder, must now be added to the list of traditional risk factors for heart disease such as high blood pressure and high cholesterol. Depression can be a symptom of low magnesium status. So can anxiety, panic attacks, irritability, hyperactivity, and over-sensitivity to loud noises. Do these newly found risk factors cause heart disease, or are they risk factors because the, as well as heart disease, can all be aspects of low magnesium status? These chronic sources of stress can increase the human need for magnesium as well as be caused by its deficit.
Emotional stress triggers in susceptible people can even bring a sudden death due to heart attack, presumably by initiating a stress/low-magnesium crisis. Such emotional “triggers” include work stress, high-pressure deadlines, social isolation and loneliness, low socioeconomic status, anxiety, war, fear of war, anger and rage. Identical stress triggers cause more human heart attacks regardless of age, race, gender, or geographic location, including continent.
Mental stress, such as working out a math problem, can be shown to have impact upon the magnesium-stress response connection, since it can bring on heart attacks in people with heart disease.
Part IV. Stress, Magnesium and Aging
We are hearing a lot about stress in the health media, and rightly so as this constant companion to our lives brings on the fight-or-flight syndrome, a stress response that, when activated, has been shown to shorten lifespan. When we realize that the stress response is exacerbated when we are low in magnesium, that we are living on low-magnesium foods for the most part, and that our lifestyles are more and more filled with chronic stresses and stressful events, we are not surprised to see that several aspects of magnesium deficiency are remarkably like aspects of the aging process.
When faced with out stressful lifestyles, coupled with a society presenting a chronically low-magnesium/high-calcium diet, what is our best defense? For many of us, magnesium supplements can help to preserve or restore a healthy Mg:Ca balance, so important to our health in these stressful times.
Peter Gillham's Natural Calm
A Testosterone Breakthrough to Restore Health and Youth
May 29, 2006 07:17 PM
There is a powerful new performance-enhancing ingredient clinically proven in humans. Its called LJ100 Tongkat Ali. Four years ago no one in the United States had heard of Tongkat Ali. Today the herb is becoming increasingly well-known as an athletic performance enhancer, overall youth-promoting agent, and libido builder.
Tongkat Ali is the popular folk name for Eurycoma Longifolia, a medium sized, slender rain forest tree. The name Tongkat Ali means Ali’s walking stick and the plant is native to Malaysia, lower burma, Thailand and Indonesia. Tongkat Ali enjoys a history of use that dates back to the 1700’s, and today there is a growing body of serious science that corroborates its traditional uses, specifically for the patented and proprietary brand LJ100 Tongkat Ali standardized extract containing 28% bioactive glycopeptides.
LJ100 Tongkat Ali
LJ100 is a proprietary, patented ingredient, and has become recognized as the premier brand of Eurycoma Longifolia for supplements that build and tone muscles, boost energy levels, decrease body fat, slow the aging process, and increase libido for health-conscious consumers. LJ100 has undergone an exclusive, patented extraction process to capture the most potent, biologically active compounds. SourceOne Global Partners, headquarters in Chicago, holds the exclusive distribution rights to market and sell LJ100 Tongkat Ali in dietary supplements.
ATP and Lean Muscle
In studies, LJ100 Tongkat Ali extract greatly increases ATP production. ATP, or adenosine triphosphate, is the basic unit of energy in the body, responsible for keeping us alive and going. By increasing ATP, overall energy and vitality are increased. Most people seek more energy and LJ100 Tongkat Ali provides it, without hyper stimulation, jittery nerves or insomnia. Promoting human energy production is a valuable health benefit by itself to make LJ100 Tongkat Ali an enduring botanical superstar. People want energy more than just about any other functional attribute.
Endocrinologists have known for a long time that testosterone increases the body’s ratio of lean muscle mass to fat. In both animals and humans, LJ100 Tongkat Ali increases muscle mass. In a study of men, half the subjects ingested LJ100 and half did not. In an eight-week physical training program the men who consumed LJ100 experienced greater gains in muscle mass and strength than those that did not. This demonstrates the powerful anabolic properties of Tongkat Ali. Instead of turning to the use of dangerous and potentially lethal steroids, it is recommended that more athletes opt for Tongkat Ali. In Malaysia, many professional field hockey players use LJ100 Tongkat Ali as an androgen and swear to its performance-enhancing effects. According to Chris Kilham, ethno botanist, author and lecturer, in a recent article in Physical Magazine,. “LJ100 Tongkat Ali has potential to revolutionize the sport nutrition category.”
Maintaining Normal cortisol / Testosterone Ratios
LJ100 is clinically proven to enhance weight loss and maintain high energy levels by maintaining normal levels of cortisol and testosterone during weight loss. More particularly, LJ100 studies have shown it to help maintain normal (low) cortisol and normal (high) testosterone levels during the stress of weight loss. This hormonal control provides energy to a person in a weight loss phase while simultaneously helping them lose weight. As a result, effective doses of LJ100 help prevent the body from seeking to gain weight by storing fat and increasing appetite. LJ100 can help stop the “yo-yo” diet effect where a dieter’s initial weight loss of a few pounds sends the body into catabolic state, leading to binge eating and fat storage.
LJ100’s Testosterone Breakthrough
LJ100 Tongkat Ali root contains numerous beneficial compounds, including potent protective antioxidants which inhibit cellular aging. What excites many people about LJ100 Tongkat Ali is that the root significantly boosts libido in men and women by increasing testosterone. Agents identified as glycoproteins are now proven to be the libido boosting ingredients in the plant.
Increasing testosterone is the key factor is the key factor in increasing libido. Testosterone is the most important of the male sex hormones, known as androgens, produced in the gonads. Testosterone plays a key role in the development and maturity of male sex organs. The hormone promotes secondary sex characteristics, including appearance of facial hair, enlargement of the larynx (producing a deeper voice), sexual desire and sexual behavior. Testosterone also stimulates metabolism, promotes lipolysis (Burning of fat), increases the formation of red blood cells and accelerates muscle growth.
Testosterone doesn’t stay with us from age 30 or so, blood levels of this hormone decline at a rate of about 2 percent per year. By age 50, the level is around 55 percent. As testosterone decreases, muscle tone, energy and sex drive all begin to decline. But testosterone is not just for men. The same decline in testosterone occurs in women, though the amounts involved are lower. In both sexes, sex drive, function, fat metabolism and energy decline into middle age.
One of the questions that many health researchers have pondered is what if you could boost your testosterone levels to more youthful levels? With LJ100 Tongkat Ali extract you can. And that makes LJ100 are true fountain of youth.
LJ100 Tongkat Ali “is the Greatest”
Don’t be fooled by wannabes. Only LJ100 delivers efficacy, standardization and supporting scientific research. When compared against lesser quality products, research showed LJ100 to increase serum testosterone levels 100% after two weeks, while some other products showed only an 8% improvement in serum testosterone level. Ali is the greatest only if it is LJ100 TongKat Ali.
Dr. Zheng-Xian Liu, PhD, has more than 18 years of experience in the Nutraceutical business and more than 34 years of experience in R & D. he received a doctorate of biochemistry and nutrition at Virginia Polytechnic Institute and State University. He was an NIH post-doctorate research fellow at Duke University Medical Center, specializing in free radical biochemistry, and a Pratt research fellow in nutrition. He also served as a member of the editorial board of journal of Advancement in Medicine and has published more than 60 papers in peer-reviewed scientific journals.
May 23, 2006 12:18 PM
Acai, one of the latest, hot new health food discoveries from the Amazon rainforest boasts some impressive credentials as a source of omega-6 and omega-9 fatty acids, vitamins A, C and E and more than 50 other antioxidants, especially anthocyanin—the powerhouse pigment found in red wine and blueberries.
Proponents of acai, which is actually the purplish fruit of Euterpe oleracea, a short palm found in abundance in Brazil, claim this superfood promotes healthy cholesterol, supports the immune system and protects the heart. With the publication of a new study in the Journal of Agricultural and Food Chemistry, they might be able to add “fights cancer” to that list as well.
The study, conducted at the University of Florida, tested the effect of pure acai juice-stripped of any lipids (EFAs) and cellulose material on HL-60 human leukemia cells in vitro. Researchers also evaluated five other extracts or “fractions” of the fruit, which contained different mixtures of antioxidants, for their effect on leukemia cells. They found that the extracts "reduce cell proliferation from 56% to 86%, most likely by damaging the cells enough to cause them to self-destruct."
Journal of Agricultural and Food Chemistry 54(4):1222-1229, 2006
July 15, 2005 12:54 PM
The FDA has not given stevia the “generally recognized as safe” label; however, the herbal compound has been used for hundreds of years without any recorded side effects. Japanese studies found that the sweetener consistently yielded a nontoxic status, even after extensive toxicity trials. The Japanese have used stevia for years with the approval of Japanese control agencies, and in Paraguay the herb has enjoyed hundreds of years of consumption with no reports of detrimental side effects. No anomalies have ever been observed in cell, enzyme, chromosomal or other significant physiological parameters during these toxicity tests. Stevia has not been associated with any form of cancer or birth defects. Stevia consumption in Japan was approximated at 170 metric tons in 1987 with no cases of documented side effects (Bonvie, 38).
Scientific Toxicology Studies
Comprehensive and tedious clinical studies in Japan have more than established the fact that stevia can be taken safely. One such study used over 450 rats who were fed stevia for up to two years with doses many times greater than human consumption.
No changes were observed in organ weights, blood biochemistry, growth, appearance, or cellular function (Bonvie, 38). The Japanese have found no indication that stevia affects fertility or unborn children and have never linked it to cancer or other cellular mutations. (NOTE: Diabetics and people with other medical conditions should always consult their physician before using this or any other dietary supplement and should never alter or stop their medication unless advised to by their physician.)
Guggulsterones - Natural Support for Cholesterol Health
June 29, 2005 10:44 AM
Today’s lifestyle, with its high-fat, processed food diet, lack of exercise, and high stress levels, leaves you at risk for imbalanced cholesterol levels. Source Naturals is committed to your optimal health and longevity. That’s why we developed GUGGULSTERONES. GUGGULSTERONES is a natural solution to help keep your cholesterol levels in the normal range. Guggulsterones are compounds found in guggul, the resin of a shrub used in traditional Ayurvedic herbalism to support a healthy heart. Research shows guggulsterones help maintain cholesterol levels in the normal range by helping to promote bile production, which removes cholesterol from the blood. They also boost thyroid activity, which supports cholesterol regulation by the liver. Source Naturals offers you natural guggul extract, standardized to provide a clinically effective daily dosage. As one of the most important botanicals to support cardiovascular health, GUGGULSTERONES is at the heart of Source Naturals’ commitment to empower people to take charge of their own health.
Cholesterol, Guggulsterones and Bile Production
Much of the cholesterol made by your liver is utilized to create bile, a substance used in digestion to emulsify fats. Because excess cholesterol and triglycerides are excreted from our bodies in the form of bile, it is important to support the liver’s bile-producing mechanism. Research shows that certain guggul compounds— guggulsterones—help maintain cholesterol levels in the normal range and act at the farnesoid X receptor (FXR) to promote bile production. Guggulsterones appear to be farnesoid X receptor (FXR) antagonists. FXR is a bile acid receptor. If FXR is activated, this results in down-regulation of the amount of bile acids produced by the liver. Bile is made out of cholesterol, which gets used up when bile is produced. When bile levels are high, the production of more bile is slowed through negative feedback of the FXR pathway. As steroids, guggulsterones can enter the nuclei of liver cells and block FXR, which results in more bile production.
Guggulsterones and Thyroid Stimulation
Guggulsterones have been shown to stimulate thyroid activity in animal studies. This is important because 90% of individuals with sluggish thyroid glands also experience challenges to healthy cholesterol levels. Since the thyroid regulates the metabolic rate of many organs, when thyroid hormone levels are too low, the body’s overall metabolic rate declines. This impairs the liver’s ability to clear cholesterol from the bloodstream. The liver regulates cholesterol levels in blood as well as producing bile, and it contains thyroid hormone receptors. This is how the thyroid gland controls the metabolic rate of the liver. Several studies have shown that guggul supports normal cholesterol levels, including LDL, serum triglycerides, and HDL levels. Because normal levels of serum lipids, including cholesterol, are supported by increased circulating thyroid hormones, it is believed guggul works by stimulating the thyroid gland, in addition to its effects on bile production.
Clinically Effective Dosage
According to several clinical studies, the amount of guggulsterones used to maintain normal cholesterol levels is 75 mg per day, when taken with a diet low in saturated fats. This is the daily dose delivered by SOURCE NATURALS GUGGULSTERONES.
A Wellness Revolution in Cardiovascular Care
At a time when our cardiovascular health faces numerous lifestyle challenges, research into the remarkable heart-supportive properties of the plant world is critical. Source Naturals is your connection to this research, dedicated to quickly bringing you nutritional benefits now available only through the natural products marketplace.
Some Final Thoughts
June 22, 2005 09:54 PM
Some Final Thoughts
One of the important proofs of the belief Pariza and Cook have in this supplement is to learn that they both take it themselves.
Cook says it is the only supplement he takes, and he believes he will take it the rest of his life. He was naturally thin because of intense exercise, but he believes that it has helped him to keep inches off during long weeks of travel. Pariza, for his part, has lost three inches from his waist during the last year, as well as about seven pounds. He said he has less of an appetite. He says he feels warmer, probably an effect of a faster metabolism. He warns that this is not a quick fix. When he first started taking this supplement, he found virtually no results. He was disappointed. But the results have come.62
Another significant thing to remember is that, today, scores of scientists around the country are now studying this nutrient. The results will pile in human studies and in other long-term clinical trials. These will give broad indications of the use of this natural, previously unrecognized nutrient.
Why would CLA be involved in so many functions?
If human studies hold true, and the expectation is that they will, you might consider this the next aspirin or the next vitamin C. Vital, remarkable nutrients seem to work on a basic level and impact a variety of systems. This is the case with CLA. What a remarkable piece of science that emerged from a charcoal grill. So, the next time charcoal briquettes sizzle with the drippings of a nice burger, remember how science has found that life, with its remarkable chemistry, finds a way to survive and thrive. No better example exists than that beef cooking on the grill. Sizzling steak covers itself with dangerous chemicals that can cause cancer. Many people feared that fact for years, and science studied those dangers earnestly. How encouraging that nature thankfully also provided other chemicals that counteract, partially at least, the effects of these dangers. CLA, just another highway of chemicals, is a quiet blessing, wiping out carcinogens, blocking dangerous fat, and striving to keep our veins clear. And it was there all along, doing its job, just waiting to be studied and understood. Now that nearly two decades of research are beginning to show how this substance can benefit our lives, a celebration of nature’s bounty seems to be in order. Let’s light up the old grill. Shall we make it steaks or burgers this time?
June 14, 2005 06:26 PM
by Catherine Heusel Energy Times, October 1, 1998
Quitting a bad habit presents quite a challenge. Just ask anyone who's ever tried to give up cigarettes. Or alcohol. Or even coffee. You start out with the best of intentions but cravings can push you off the straight and narrow. The result: giving up a nasty habit often means regenerating your resolve and trying again. And again. And again. While some blame an inability to give up a bad habit on poor will power, in actuality, the tenacious chains of these habits may derive from the body as well as the mind. "People don't seem to realize the effects these substances have on the body," says Joan Mathews-Larson, Ph.D., director of the Health Recovery Center, in Minneapolis, and author of Seven Weeks to Sobriety. Dr. Mathews-Larson is one of a growing number of addiction professionals who stress physical recovery when giving up a drug, whether it's caffeine or cocaine. "You can't disrupt your internal chemistry for months or years on end and then expect your body to automatically bounce back," she says. "You have to give it some help."
Breaking Off is Hard to Do
The substances we love to overdo all share a common characteristic: they mimic or enhance the body's chemical messengers. Opiate drugs such as heroin, for example, are virtually identical to substances called endorphins, neurochemicals that the body produces to mask feelings of pain. (When an injured Kerri Strug performed her final Olympic vault, her endorphins enabled her to push past her protesting nerve endings.) Stimulants such as caffeine and nicotine can provide a "rush" similar to that produced by adrenaline and noradrenaline, the neurochemicals that provide the quick and excited feeling that swells down your spine during frightened or thrilling moments. On the other hand, some drugs (notably alcohol and cocaine) boost the activity of several different neurochemicals, including those that control sensations of pleasure. From a biological perspective, then, none of the drugs that people take are totally unfamiliar to the body. Your body makes similar chemicals all the time, in response to specific events and needs. "The main advantage of drugs is that they act powerfully and immediately," explains Andrew Weil, M.D., in his book, From Chocolate to Morphine: Everything You Need to Know About Mind Altering Drugs. "Their main disadvantage is that they reinforce the notion that the state we desire comes from something outside us."
Another serious disadvantage of drugs resides in their impact on the body's everyday neurochemical balance. Under normal circumstances, the body maintains its internal chemical environment on a fairly even keel. It may pump out oodles of adrenaline in response to a specific threat, like a near miss on the highway, but for every such scary "high" a corresponding low sets in: that rubbery-kneed sense of relief you feel when things calm down.
Over time, the body mistakes the introduction of mind-altering, foreign chemicals as an excess of its own production of neurochemicals. As a result it slows down its own manufacture of these vital substances. So when you stop drinking caffeine or other stimulating drugs, the body finds its neurochemical receptors begging for relief: Cravings raise their ugly heads while so-called withdrawal symptoms raise your discomfort level. A general sense of ill health sets in until the body's natural production of neurotransmitter production reaches an acceptable level.
Breaking a bad habit may be complicated by a lack of regenerative health habits. "A proper diet is pretty low on an addict's list of priorities," says Mathews-Larson. "Most of the people we see live on fast food and junk food." Many people trying to give up bad habits are attacked by the chemical and physical problems resulting from eating fatty foods and not exercising: their bodies are chemically and physically challenged from a poor lifestyle.
Fortunately, recovery from a bad habit can be enhanced by balancing your diet, exercising and using nutritional supplements to straighten out your interior biochemical environment.
"We target substances that are essential for maintaining optimal brain chemistry," points out Mathews-Larson. Foremost among these substances are a variety of amino acids that the body needs to rebuild its supply of neurotransmitters. In addition, nutrients such as B vitamins and vitamin C are often in short supply among those who indulge in addictive drugs and alcohol.
Exercise and meditation are equally important to recovery, since both activities naturally prompt production of mood-enhancing neurochemicals. (The so-called "runner's high" is believed to result from endorphins and other neurochemicals stimulated by jogging.) More importantly, natural stimulation that pushes the body to create its own, endogenous supply of feel-good chemicals produces a longer sense of well-being than the transitory high induced by drugs and alcohol. "The potential for highs is always there, and many techniques exist for eliciting them," declares Dr. Weil. "Drug highs differ from other highs only in superficial ways."
To experienced treatment professionals such as Mathews-Larson, kicking a long-standing habit depends on learning to appreciate the natural high of good health, through an overall healthy lifestyle. "It's not enough to just stop using the substance you abused," she contends. "You have to build a high quality of life for yourself, so you can fully enjoy every day."
Recommended Reading: Seven Weeks to Sobriety, by Joan Mathews-Larson (Fawcett Books, 1997) Healing Anxiety With Herbs by Harold H. Bloomfield. (Harper Collins, 1998.)
Mega Mind - re-align your body systems ...
June 03, 2005 05:24 PM
Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MEGAMIND™ is a Bio-Aligned Formula™ that helps align multiple systems: neurotransmitter production, antioxidant defense, energy generation, circulation, and myelin sheath generation. Complementary Formulations Source Naturals can help keep your mind sharp and alert. Use MENTAL EDGE® Bio-Aligned Formula for foundational support, or MEGAMIND, when memory symptoms* are severe. HIGHER MINDTM is an additional Bio-Aligned choice. Take these formulas alone or as the core of a program that includes additional ingredients such as DHA (NEUROMINS®), GINKGO-24™, PHOSPHATIDYL SERINE, VINCAMINE, and VINPOCETINE.
In today’s complex world, we are bombarded with information. Our ability to process this massive input depends on how well we nourish the multiple body systems related to brain health. In addition, normal aging is associated with impairment of certain mental functions, according to the National Institute on Aging. The brain undergoes changes including functional decline in neurons important to learning, memory, planning, and other complex mental activities, as well as increased oxidative stress. In healthy people, these changes may result in varying degrees of age-related memory decline. Source Naturals can help, with a full line of cognitive support products.
Mental Edge®: Bio-Aligned Formula
MENTAL EDGE is a literal multivitamin for your brain. MENTAL EDGE supports production of neurotransmitters including acetylcholine, antioxidant defense, energy generation, stress response and myelin sheath generation. It features nutrients needed for production of neurotransmitters— chemical messengers in the brain’s communication system. One of the most important of these is acetylcholine, which is necessary for memory and muscle movement. MENTAL EDGE also contains antioxidants—vitamin C, ginkgo, DMAE, and zinc—to protect the neuron cell membranes where electrical signaling takes place. Adaptogenic herbs provide the brain with support and energy to deal with environmental stress. Energy-generating ingredients such as ginkgo and B-vitamins are vital to the high-powered functioning of your brain. Vitamins B-5 and B-12 are also important for formation of myelin, a substance that forms a protective insulating cover around certain nerve fibers and increases nerve impulse conduction.
MegaMind™: Bio-Aligned Formula When memory symptoms* are severe, you may need a formula with extraordinary cognitive support. MEGAMIND addresses many of the same body systems as MENTAL EDGE, but does so with megadoses of brain nutrients, such as L-pyroglutamic acid and vitamin B-1 for neurotransmitter production. It also adds bacopa and the inhibitory neurotransmitter GABA to support neurotransmitter production, and higher potency vitamin B-12 for myelin sheath generation. Like MENTAL EDGE, MEGAMIND supports energy generation and antioxidant defense. MEGAMIND augments basic support for the brain’s immense energy requirements with higher potency vitamin B-1, and with one of nutritional science’s most advanced, high-tech nutrients, alpha-lipoic acid. Lipoic acid is also an antioxidant, as are gotu kola and grape seed. MEGAMIND also supports circulation with ginkgo and gotu kola.
Mega Mind: Bio-Aligned Formula HIGHER MIND is another multi-system support formula, which features phosphatidyl serine, a structural component of nerve cell membranes, and the botanical vinpocetine. HIGHER MIND nourishes neurotransmitter production, cell membrane stability, energy generation, antioxidant defense and myelin sheath generation.
Neurotransmitter Production: Bacopa, GABA, L-Glutamine, L-Pyroglutamic Acid, Taurine, N-Acetyl L-Tyrosine, Manganese, Vitamins B-1 & B-6
Acetylcholine Production: Acetyl L-Carnitine, DMAE, Gotu Kola, L-Pyroglutamic Acid, Vitamin B-5
Myelin Sheath Generation: Vitamins B-5 & B-12
Energy Metabolism: Acetyl L-Carnitine, Ginkgo Biloba, L-Glutamine, alpha-Lipoic Acid, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6 & B-12, Biotin,Folic Acid
Circulation: Ginkgo Biloba, Gotu Kola
Antioxidant Defense: DMAE, Ginkgo Biloba, Gotu Kola, Grape Seed, alpha-Lipoic Acid, Zinc, Vitamin C
Complementary Cognitive Support Products
For additional support, you can supplement Source Naturals Bio-Aligned formulas with these single ingredient products: ACETYL L-CARNITINE and DMAE are both important to the synthesis of acetylcholine, a key neurotransmitter associated with higher cognitive functions, such as learning and memory. DHA (NEUROMINS®) is an omega-3 fatty acid that plays a significant role in cerebral development, especially during fetal development and infancy. GINKGO is renowned for promoting blood flow to the brain. Source Naturals GINKGO-24™ is a standardized concentration of Ginkgo biloba leaves, yielding 24% ginkgo flavone glycosides and 6% terpenes (the key constituents). PHOSPHATIDYL SERINE is necessary for the health of nerve cell membranes, where electrical signaling takes place. These membranes are critical to information processing. VINCAMINE, an alkaloid obtained from the periwinkle plant, supports cerebral metabolism by promoting blood flow and oxygen and glucose utilization. VINPOCETINE is a derivative of vincamine, shown in research studies to improve cognitive performance and alleviate the short-term memory loss that may accompany stress or aging.
Lifestyle Tips for Cognitive Health: A Strategy for Wellness SM
Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a high-fat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Longterm anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities, through the use of memory aids such as “to-do” lists, notes, or calendars.
Mega H- Hydrogen (H-)The Fuel of Life
June 03, 2005 05:00 PM
Our universe is composed of millions of compounds, all derived from just 106 atoms. Of these elements, hydrogen is the first and most fundamental.
Hydrogen is also the most abundant element, comprising 90% of all atoms in the cosmos. In our sun and stars, hydrogen nuclei fuse to produce helium, the second element. This generates the enormous energy that powers life on earth. And just as hydrogen fuels the sun, so, in the human body, it is the essential factor in the electrochemical process that produces ATP, the energy molecule. Virtually all the millions of biochemical processes that occur every second of our lives are powered by ATP. These facts are well established. But they are so basic that, until now, they have been overlooked in the world of nutritional science. It took the dedicated research of Dr. Patrick Flanagan to harness the power of active hydrogen for health and human development.
Introducing a revolutionary breakthrough in the field of nutritional science: MEGA H-™ Active Hydrogen (H-), the Fuel of Life.
The Creation of Mega H-
For 30 years Dr. Patrick Flanagan’s life work has been to discover the health and longevity secrets of the Hunza people of the Himalayas. It is believed a much greater percentage of people there live past the age of 100, with far less of the diseases that ravage the West. The locals claimed that their secret was the cloudy, mineral-rich water that rushes down from the Himalayan glaciers. In studying the properties of this Hunza water, Dr. Flanagan found that silica crystals dissolved in the water were able to hold negatively charged hydrogen ions (H-). These compounds are technically called silica hydrides. This makes Hunza water a power source, filled with the same active H- that powers the human body.
Typically hydrogen has one positively charged proton in the nucleus and one negatively charged electron orbiting the nucleus. The two opposite charges balance each other, resulting in no charge. Active hydrogen, on the other hand, contains two electrons orbiting the nucleus, creating a negative charge. It is this active hydrogen in its charged form that the body needs to carry out its crucial functions. Dr. Flanagan has recreated this silica hydride compound as MEGA H-™.
Cellular Energy: ATP, Hydrogen and Mega H-™
ATP, adenosine triphosphate, is composed of three phosphates. The breaking of the bond between the second and third phosphates releases the energy to power virtually all cellular processes. Amazingly, we all generate enough metabolic energy to produce our own body weight in ATP every day just to function! Every second, each of our approximately 50 trillion cells consumes and regenerates 10 million molecules of ATP.
This massive energy generation (ATP production) is the fundamental core function of every human cell. Without it, basic activities such as cellular repair, and protein, enzyme, hormone and neurotransmitter synthesis would not occur. DNA repair and cell reproduction would cease. Thoughts, feelings, communication, and our ability to experience the world through our senses and change it through our actions would stop. The negative implication of poor energy generation for our health and vitality levels is significant. Many factors such as aging, poor nutrition and pollution can impede this critical energy generation. Negatively charged electrons from hydrogen are the source of the energy needed to generate this staggering amount of ATP. This energy production takes place in the mitochondria of the cells at the final stage of the Krebs Cycle, called the electron transport chain. Typically, the hydrogen comes from the breakdown of carbohydrates from food, which yields hydrogen as well as carbon and oxygen. But MEGA H-™ is an alternative, electron- rich source of hydrogen to power energy generation. In fact, MEGA H-™ has been shown to double the production of ATP and NADH, according to in vitro studies. (NADH is the coenzyme form of vitamin B-3, niacin, that carries hydrogen to the production site of ATP.) If this alone was all that MEGA H-™ could accomplish, it would be the most significant nutritional compound yet discovered. But its properties go far beyond energy generation. It is the body’s most efficient and effective antioxidant. MEGA H-™ also increases cellular hydration and the uptake of nutrients into each cell by lowering the surface tension of water (making water “wetter”). And it can improve athletic performance by lowering lactic acid levels after strenuous workouts.
Aging and Antioxidant Defense
Energy Decline: As we age, there is a decrease in our bodies’ ability to generate cellular energy—and oxidative damage may be a primary factor. Many scientists now accept the theory of aging first proposed by noted scientist Denham Harman, M.D., Ph.D., who argued that “aging changes are induced by free radical reactions, largely initiated by the mitochondria … the rate of damage to the mitochondria determines our life span.” Why is this? While oxygen is necessary for human life, the very act of breathing generates free radicals. Our mitochondria— tiny energy production plants—are the chief source of oxidants produced in our bodies. It is believed these oxidants damage the mitochondria in which they are produced, including the inner mitochondrial membrane, which is the site of ATP production. This would seriously impair the ability of mitochondria to meet cellular energy demands. The result: signs of normal aging such as impaired memory, hearing, vision and stamina.
DNA Damage: Oxidants also can damage the cell’s DNA. Hydroxyl radicals cause DNA strands to break; if breaks occur in both strands of DNA, the cell cannot repair the damage and will die. Normally, the body has mechanisms to correct or remove damaged cells. However, as we age and cellular energy production declines, the ability to correct these errors is significantly reduced. Left unrepaired, DNA errors may be passed on when cells divide. Over time, these errors can silently accumulate, leading to cellular changes that go unnoticed until body system imbalances become evident.
World’s Most Elemental Antioxidant
MEGA H-™ may be the world’s most powerful antioxidant. It is possible to measure the Oxidation Reduction Potential (ORP) of any compound. This rating, which measures the number of electrons present in relation to protons, ranges from (plus) +1,200 to (minus) -800 millivolts; the stronger an antioxidant is, the closer its ORP would be to -800. The more positive the ORP reading, the fewer the number of available electrons from active hydrogen. In chemistry, active hydrogen is defined as hydrogen with an extra electron, also known as the hydrogen anion, negative hydrogen or H-. The strongest natural antioxidants up until now, such as grape seed and green tea, have ORP’s of -100. But Mega H-™ has an ORP of -778 millivolts, as compared to distilled water, making it the most potent natural antioxidant available today. What’s more, MEGA H-™ is in a class by itself, compared to other antioxidants, due to its electrochemical structure. Free radi-cals—unstable molecules that are missing one or more electrons—damage cells by taking electrons from healthy molecules to balance themselves. When other antioxidants donate electrons to quench free radicals, they in turn become reactive free radicals and require electrons from other antioxidants to become stable. The new antioxidant also requires an electron to return to stability. This process continues, resulting in an inefficient and energy-consuming free radical cascade. But MEGA H-™’s negatively charged hydrogen molecule possesses two electrons instead of the typical one. This extra electron can be donated without generating the inefficient free radical cascade. Dr. Flanagan’s profound contribution was his discovery of a method for stabilizing and delivering negatively charged hydrogen (H-). Unlike taking other antioxidants, supplementing with MEGA H-™ provides a net gain of free radical-quenching electrons into the system.
Additional Health Benefits
MEGA H-™ has been the subject of additional positive research: Increases Cellular Hydration: Water is important to cells, interstitial fluids (surrounding joints, muscles and organs), and the matrix of blood. As the body’s primary fluid, water serves as a solvent for nutrients. Since water is used to carry nutrients into the cell, it is theorized that increased cellular hydration also increases the bioavailability of nutrients. Water also eliminates toxins and waste products from the body. From energy production to joint lubrication, all our systems depend on water. It has been theorized that aging results in cell dehydration. A study done by Gary Osborn and H. Salinas, M.D. of the Texas Institute of Functional Medicines suggests that silica hydride supplements like MEGA H-™ increase intracellular, extracellular and total body water levels. It is theorized they work by decreasing water’s surface tension, which allows water and nutrients to more easily enter cells and become available for use by the body. Assists In Exercise Recovery: During strenuous exercise, the oxygen supply to muscle cells is insufficient to meet energy demands. Muscle cells then turn to anaerobic respiration to continue to generate energy. This creates lactic acid, which diffuses into the blood, causing muscle fatigue, soreness and loss of endurance. A placebo-controlled study on six healthy males showed that blood lactate levels significantly decreased after exercise when silica hydride supplements were taken for one week before an exercise trial.
The Scientist Behind Mega H-™
This revolutionary approach to nutrition and health is the brain child of Dr. Patrick Flanagan. Dr. Flanagan was a child prodigy with an intense interest in electronics, biochemistry and physics. At the age of 12, he invented a guided missile and atom bomb detector. This technology was subsequently adopted for use by the U.S. government. At 14 he developed the Neurophone®. This device transmits acoustic information to the brain by means of radio waves into the skin, bypassing the eighth cranial nerve, and may allow some deaf people to hear. By the age of 18, he was named one of the Top Ten most promising young scientists in America by Life Magazine. Dr. Flanagan’s work with MEGA H-™ has its roots in his collaboration with Dr. Henri Coanda, a respected scientist who died in 1972. Dr. Coanda passed along his investigation into Hunza water to Dr. Flanagan. MEGA H- is the culmination of decades of research to bring the energizing and anti-aging benefits of active hydrogen (H-) to the world.
Hydrogen (H-)The Fuel of Life
MEGA H-™ is the first supplement available in the natural foods industry to provide a large reservoir of freely available electrons to power the body’s diverse energy functions.
LYCOPENE - Tomatoes Like You’ve Never Seen Them Before ...
June 03, 2005 10:51 AM
It’s hard to imagine that the ancestor of the beefsteak tomato was a tiny yellow fruit first harvested by the Incas. Tomatoes have come a long way since their origin in the Andes, becoming more popular than any other fruit or vegetable in America. (Botanically, the tomato is really a fruit, despite the Supreme Court’s 1893 ruling that it’s a vegetable.) Today, our appreciation of this dietary staple is entering a new chapter. Modern nutrition science has delved into the biochemistry of the tomato and discovered unique phytonutrients with powerful influences on the human body. Utilizing this research, Source Naturals has introduced a concentrated form of the tomato’s most vital nutritional compound: Lycopene.
Tomatoes and their Healthy Red Color
Lycopene is the pigment that gives tomatoes, watermelons and some grapefruits their healthy red color. Found most abundantly in tomatoes (Lycopersicon esulentum), lycopene is a member of the carotenoid family. This group of phytonutrients are major contributors to the health of the human race. (Phyto is derived from the Greek word for plant.)
Over 500 different carotenoids have been identified by science, and almost 10% of them are found in human blood and tissue. Best known is beta-carotene, whose important benefits have been well-documented. Other familiar phytonutrients include allicin from garlic, and capsaicin from chili peppers. Lycopene, lutein, alpha-carotene and betacarotene are the most abundant of the carotenoids present in human blood and tissues. Human breast milk has been found to contain 19 carotenoids, including lycopene. Like many carotenoids, lycopene has evolved as an integral part of human biochemistry, with many benefits to our well-being. Since mammals cannot synthesize it, lycopene must be obtained from the diet.
Lycopene and Prostate Function
One of the most interesting aspects of the way phytonutrients interact with the human body – beyond their broad spectrum antioxidant activity – is their tendency to be “organ specific.” Different carotenoids have an affinity for different organs in the body! In the case of lycopene, it’s the most plentiful carotenoid in the prostate gland. Studies have explored the link between diets high in lycopene and proper prostate function.
Lycopene Protects Cells
Research has shown that lycopene may protect DNA by its powerful antioxidant activity against singlet oxygen free radicals, dangerous forerunners to cellular damage. Lycopene was found to be the most efficient biological carotenoid to neutralize singlet oxygen – almost 3 times more powerful than beta-carotene. Also, lycopene has a “sparing effect” for beta-carotene: lycopene sacrifices itself to free radicals so that beta-carotene can be reserved for conversion to vitamin A. Lycopene has another ability that has excited further investigation. It increases gap junctional intercellular communication, which is the chemical and electrical coupling between neighboring cells. This enables a healthy exchange of the signals that regulate normal growth – thereby offering a protective influence on cellular reproduction.
Getting the Most From Tomatoes
Until recently, lycopene was not commercially available, and hasn’t been studied as extensively as has beta-carotene. But now, thanks to a unique (non-chemical) proprietary process, lycopene can be obtained from specially bred and cultivated tomato varieties that are rich in lycopene, and very red. Source Naturals LYCOPENE is standardized to 5% lycopene in a base of vegetable oil. It also contains small amounts of other carotenoids, naturally present in tomatoes. While it’s important to continue eating fruits and vegetables, we can also benefit from the fruits of nutritional research. This is especially important since so much of our food supply has become denatured, lacking the traditional nutrition our bodies require. Source Naturals LYCOPENE is a significant step toward reclaiming the nutrients we need to help create a life of health and vitality. Get a taste of the 21st Century – Source Naturals LYCOPENE.
Lutein 6mg, 20mg, help stop macular degeneration ...
June 02, 2005 01:39 PM
One of the more surprising discoveries of modern nutritional science is that the very pigments which give brilliant color to our fruits and vegetables are powerful nutrients which can protect us from the rigors of time and environment. Lutein is one of the most recent discoveries in this field. In our diets, it’s found most abundantly in dark green leafy vegetables such as spinach, collards and kale. Like beta-carotene, lutein is a powerful antioxidant which studies show can contribute to the protection of cells. But the most promising application of lutein may be its beneficial influence on the eyes, particularly in regard to macular degeneration. Source Naturals LUTEIN is a concentrated source of this important natural nutrient.
Like the beta-carotene that makes carrots orange and the lycopene that makes tomatoes red, lutein is a carotenoid. It is the pigment that makes corn yellow, and gives marigolds their brilliant golden color. One of the most interesting aspects of the way carotenoids interact with the human body – beyond their broad spectrum antioxidant activity – is their tendency to be “organ specific.” Different carotenoids have an affinity for different organs in the body. In the case of lutein, it is found concentrated in the structure of our eyes.
Vision and Macular Health
The process of vision involves light being focused through the lens and onto the retina, the paper-thin tissue lining the back of the eyeball. The central portion of the retina, called the macula, receives the most light. Its millions of cells produce the sharp vision needed to read and see objects clearly. With age, tiny blood vessels grow over this area, causing a gradual distortion and loss of vision. This degeneration of the macular region of the retina is the leading cause of irreversible visual impairment in the USA today. It affects almost 20% of people past the age of 65. Research has shown that these people have lower than normal amounts of macular pigment, which suggests the protective role played by these pigments. In fact, the latest research suggests that low levels of macular pigment is a cause, rather than a result, of macular deterioration.
Lutein – The Eyes Have It
Lutein and another carotenoid called zeaxanthin are the most dominant pigments in the macular region of the retina. (Source Naturals LUTEIN contains 5-7% zeaxanthin.) Their antioxidant properties help maintain the integrity of the blood vessels that supply the macular region of the retina: providing protection from photo-oxidation, the result of light striking the fatty acids in the retina. It seems that lutein is particularly active against the blue part of the spectrum, which can be the most damaging to our eyes. One study using lutein supplements resulted in a 15% increase in macular pigment levels after 72 days. In another study, people who consumed the equivalent of 6 mg of lutein per day were 40% less likely to experience macular problems. Another study using sets of identical twins demonstrated that macular lutein concentrations were related to dietary lutein. After consumption, lutein is found in significant quantities in blood serum, suggesting high bioavailability.
Our Connection with Plants
In this era of biochemistry, we’re rediscovering our vital connection with plant life. Although research into phytonutrients is relatively new, many plant compounds are being found in significant concentrations in the human body. Their presence in our blood serum, organs, and mothers’ milk suggests they play an important role in our body chemistry, and perhaps explains why we’ve appreciated them as foods throughout history. Like many carotenoids, lutein has evolved as an integral part of human biochemistry, with many benefits to our well-being. Since mammals cannot synthesize it, lutein must be obtained from the diet. Source Naturals LUTEIN is extracted from specially grown marigold flowers high in Lutein, and purified by an exclusive patented process. So the next time you bathe your eyes in a golden bouquet of marigolds, remember their beauty really is in the eye of the beholder.
Bioflavonoid Complex - Botanical Antioxidant Protection
June 01, 2005 09:15 AM
Bioflavonoids occur as pigments in plants, where they are found in close association with vitamin C. Together, bioflavonoids and C provide antioxidant protection, helping plants withstand harsh environmental conditions. BIOFLAVONOID COMPLEX features potent botanical extracts, many of them standardized to specific beneficial constituents. Included are bilberry, ginkgo biloba, grape seed, green tea, hawthorn berry, quercetin, and silymarin. The formula is enhanced by the addition of vitamin C as highly bioavailable magnesium ascorbate.
AHCC and its antifungal and antibacterial activity ...
May 25, 2005 11:19 AM
AHCC and its antifungal and antibacterial activity
The bacteria tested:
S. aureus, P. aeruginosa, P. fluorescens, Proteus vulgaris, Bacillus subtilis, B. cereus, B. megaterium, B. subtilis, Escherichia coli, Enterobacter aerogenes, Micrococcusluteus and Mycobacterium phei.
1.A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju Patrick H.K. Ngai, T.B. Ng* Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China Received 23 June 2003; accepted 25 November 2003
Red Wine and Resveratrol
May 23, 2005 09:20 AM
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis:
Implications for protection against coronary heart disease Authors: Pace-Asciak, Cecil R.a; Hahn, Susanb; Diamandis, Eleftherios P.b; Soleas, Georgec; Goldberg, David M. Affiliations: a. Department of Pharmacology, University of Toronto and Research Institute, Hospital for Sick Children, Toronto, Canada b. Department of Clinical Biochemistry, University of Toronto, 100 College Street, Banting Institute, Toronto, Ontario, M5G 1L5, Canada c. Andres Wines Ltd., Grimsby, Ontario, Canada Keywords: Atherosclerosis; Thromboxane B2; Hepoxilins; Anti-oxidants; Resveratrol; Quercetin
A number of lines of evidence suggest that red wine may be more effective than other alcoholic beverages in decreasing the risk of coronary heart disease (CHD) mortality. This protection over and above that due to ethanol itself may be explained by phenolic components with which red wines are richly endowed. We have studied the effects of the trihydroxy stilbenetrans -resveratrol on human platelet aggregation and on the synthesis of three eicosanoids from arachidonate by platelets, i.e. thromboxane B2 (TxB2), hydroxyheptadecatrienoate (HHT) and 12-hydroxyeicosatetraenoate (12-HETE). These effects were compared with the actions of other wine phenolics (quercetin, catechin and epicatechin) and antioxidants (a-tocopherol, hydroquinone and butylated hydroxytoluene). trans-Resveratrol and quercetin demonstrated a dose-dependent inhibition of both thrombin-induced and ADP-induced platelet aggregation, whereas ethanol inhibited only thrombin-induced aggregation. The other compounds tested were inactive. trans-Resveratrol also inhibited the synthesis of TxB2, HHT, and to a lesser extent 12-HETE, from arachidonate in a dose-dependent manner. Quercetin inhibited only 12-HETE synthesis, and hydroquinone caused slight inhibition of TxB2 synthesis, the remaining compounds being ineffective. De-alcoholized red wines inhibited platelet aggregation; their ability to inhibit the synthesis of TxB2 but not that of 12-HETE from labelled arachidonate by washed human platelets was proportional to their trans-resveratrol concentration. These results are consistent with the notion that trans-resveratrol may contribute to the presumed protective role of red wine against atherosclerosis and CHD.