Search Term: " D-ribose "
Ribose Energy-Boosting Heart Supporter or Sugar Trap?
January 09, 2019 09:15 AM
Ribose is a natural energy-boosting chemical that our bodies produce in order to provide our cells with the appropriate energy levels. It has been shown to support heart health by regenerating the necessary energy levels that can be depleted by cardiovascular disease. Ribose has also shown to help patients who are suffering from left ventricular diastolic dysfunction. Other advantages of ribose include: improved skin health, better workouts due to the energy increase, and aiding in the treatment of fibromyalgia.
"In fact, scientific studies show that D-ribose may help a number of serious health concerns, including heart diseases, fibromyalgia symptoms and chronic fatigue syndrome."
Read more: https://draxe.com/ribose/
A natural sugar molecule, D-ribose, found to improve heart function and blood flow
July 04, 2018 09:54 AM
D-Ribose is a simple sugar molecule that plays an important role in energy metabolism within your body by helping to produce cellular energy in the form of adenosine triphosphate (ATP). Oxidative stress can deplete ATP, which can then cause further stress, in a vicious cycle for your heart. However, D-Ribose supplements can restore levels of ATP, which can improve heart function and exercise endurance in cardiac patients. Infusion of D-Ribose after a cardiac event may even be able to prevent dangerous ischemia reperfusion injuries.
"With one occurring every 40 seconds in America, you likely know more than a few people who have experienced one."
Read more: https://www.naturalnews.com/2018-07-01-natural-sugar-molecule-d-ribose-improve-heart-function-and-blood-flow.html
Ribose is a type of sugar which is produced in the body and is of medicinal value. This organic compound is very essential in our day-to-day lives because it boosts our energy levels. Apart from energy boost, ribose is also used to relieve manifestations of chronic fatigue syndrome (CFS), fibromyalgia, and coronary artery disease. It also prevents other symptoms like pain following a workout in individuals with a genetic condition known as myoadenylate deaminase deficiency (MAD). This vital body chemical can help boost exercise ability in individuals with another inherited disorder known as McArdle's disease.
How Does D-ribose Work to Boost Energy in the Body?
The manner in which D-ribose works to deliver results is very simple and elaborate. It promotes the production of ATP (adenosine triphosphate), which is the primary source of energy for the body's cells. Healthy, active cells constantly top up their supply of ATP to get adequate cellular energy. Through increasing levels of adenosine triphosphate, the supplement can help speed up energy recovery, increase energy reserves and
As you can see, your body needs to keep its production of (ATP) at its highest possible level for maximum energy production as well as physical performance. But sometimes the supply of actual ATP molecules may be reduced due to a number of factors including physical activity and health condition. This is where D-ribose, a natural ingredient for boosting ATP levels comes in.
Is D-Ribose Only Good For All Muscular Energy Or Just The Heart?
January 22, 2014 10:32 AM
What is D-ribose
Ribose, better known as D-ribose is a sugar that gets produced by the human body or rather say body cells. Unlike normal sucrose or any artificial sugar, Ribose is an especial sugar found in a variety of foods. Generally, doctors suggest external Ribose dosages to heart patients as it’s known to improve heart function and help people obviate hearth disease and congestive heart failure. Now, here’s the question arises, is D-ribose only good for all muscular energy or just the heart?
Before answering the above question, have a look at the science behind the fact that Ribose is helpful to heart patients. Well, in simple terms, heart of the people, suffering from congestive heart failure works much harder compared to the heart of normal people. To pump blood harder, heart requires more energy and if it doesn’t get the energy, it gets tired and also makes the body tired. This is where the external dosage of Ribose offsets the energy lost by the heart, and help it work properly.
D-ribose is frequently found in energy drinks and health supplements. Actually natural foods don’t really contain free Ribose, hence health supplements or energy drinks become the best source of Ribose. Before purchasing any health supplement featuring Ribose, make sure you consult with an expert doctor. So, whether you are suffering from congestive heart failure or chronic fatigue or you just want to boost your energy before the gym workouts, consume a genuine D-ribose health supplement daily to see the difference.
How D-ribose boost energy levels in the body
October 27, 2013 09:40 PM
D-ribose is a simple sugar, prontose sugar, or 5-carbon monosaccharide. It is used by all body cells and is essential component in energy metabolism. Ribose also gives the structural backbone of body genetic materials like RNA and DNA, certain vitamins and other vital cellular compounds. It provides raw material to facilitate the production of adenosine triphosphate.
D-ribose was discovered in late 1990s by an American company. People who were suffering from fatigue and chronic related illnesses could be given pure adenosine triphosphate instead of AMP. This new supplement was produced in a stable and safe natural form that allowed it to be sold as nutritional supplement.
Ribose is an essential ingredient in stimulating the production of natural energy. It promotes the cardiovascular health, minimizes cardiac stress associated with strenuous events. Ribose enables the muscles and heat to maintain healthy energy level as well as accelerating the recovery of energy when body tissues are stressed by overwork, strenuous exercise, or disease. The physiological fuction of D-ribose is known as 5-phosphoribosyl-1-pyrophosphate, which controls the metabolic path that synthesizes energy components in all body living tissues. In case the cellular energy pool is depleted by overwork, diseases or exercise it must be replaced. 5-phosphoribosyl-1-pyrophosphate will stimulate the metabolic pathway to replenish these energy pools.
Patients with myocardial ischemia condition or reduced blood flow resulting from reduced oxygen flow to the heart may experience discomfort and chest pain. This may cause heart attack to a person with such experience. The ability of the heart cells to expand and contract depend upon the adenosine triphosphate available. The reduced blood flow lowers the level of adenosine triphosphate, but this can as well be replenished by 5-phosphoribosyl-1-pyrophosphate. D-ribose stimulates the 5-phosphoribosyl-1-pyrophosphate production, which in turn increases the level of adenosine triphosphate. This will actually restores the heart cell contractile functions and reduces ischemia.
May 17, 2008 10:07 AM
Discovered by Phoebus Levene in 1905, D-ribose is a monosaccharide, and is a component of RNA that is needed for genetic transcription. It is a stereoisomer of ribose, and although not regarded as an essential nutrient since it is synthesized in the body, it is essential for life. It also takes part in human metabolism, helping to generate energy from food, and is a component of all living cells – animal or vegetable. It is contained in ATP and NADH and we could not live without it.
Because it is contained in all living organisms, D-ribose is a common component of the human diet, and required as a supplement only for specific needs. It for this reason that the human species developed and survived: the chemicals needed for life are either commonly found in nature or are manufactured by the body itself from other raw materials which themselves are common in our diet. The other stereoisomer is L-ribose, and this plays no part in human metabolism.
Energy is needed not only to enable us to walk and to run, but also to drive every part of human physiological activity, and all of the physical and chemical processes of life. Because of its nature energy cannot travel round the body in our bloodstream as if were a chemical entity, but must be released or generated where and when it is needed. For that reason every cell in our body contains an area called the mitochondria in which energy is generated. The molecule of energy, if there is such a thing, is called ATP, or adenosine triphosphate.
ATP controls the production of energy everywhere in the body, and allows muscles to contract and relax. This muscular activity is responsible for all movement, including the circulation of our blood through heart contractions, the diaphragm movement that creates the vacuum that allows us to breathe, and the operation of the digestive system by means of the peristaltic motion of the esophagus and the intestines. Each of the two ways in which ATP is generated involves D-ribose.
One is by means of D-ribose being used to produce new ATP, and the other is the recycling of used ATP. In the latter, D-ribose and ATP react to form ADP (adenosine diphosphate and D-ribose-5-phosphate with the release of energy. This diphosphate then reacts again with the ADP to produce new ATP and D-ribose. The reaction is catalyzed by an enzyme known as a ribokinase, a phosphotransferase that specifically catalyzes reactions involving phosphorus groups with an alcohol receptor group.
The heart muscle is operated by means of the calcium pump that depends upon both calcium and ATP for its operation. When ADP and phosphate are created by the effect of calcium and ATP coming together, then energy is provided to the muscle fibers of the heart. ADP then reacts with the phosphate and D-ribose in the presence of magnesium to reform the ATP. ATP is therefore essential for the continuation of the pumping action of the heart that maintains life in all mammals.
D-ribose is also part of the base of RNA and DNA, without which there could be no life. Because the cardiac muscle is easily depleted of ATP, the presence of D-ribose is of extreme importance and it has been proved that cardiac failure begins with the reduction in energy levels of the heart muscle that can be brought about by a lack of ATP in the muscle cells.
An important property of D-ribose is that it is unchanged by the liver, which is the chemical plant of your body in which a large part of the biochemistry needed for life takes place. This means that D-ribose can be taken in the diet and pass through the liver virtually unchanged, and then be transported in the bloodstream to where it is needed for the maintenance of ATP levels. That is why D-ribose is frequently given to treat heart attacks: because it can rapidly replace lost ATP and enable the calcium pump to get to work and keep the heart beating at its normal strength. Maintenance levels of this important sugar would not go amiss.
However, there are other uses to which the body can put this marvelous substance. Among these is the body’s ability to form Coenzyme A from it. This coenzyme is needed in the body for the breakdown of fatty acids, and many other chemical reactions, and also provides the raw material for many other necessary substances in human biochemistry.
Patients with low energy levels can frequently fail to be able to recover from illness. This is because that when illness stresses your body, your mitochondria become overwhelmed with work and begin to fail to produce sufficient ATP to keep the body going. Naturally, as your energy level drops, and your body cells are unable to respond to this, then the condition you are suffering from gets worse, and become stronger leading ultimately to possible death. Your immune system is put under a great deal of stress that uses up what little ATP you have left.
That is why when people start to get really ill, they tend to fade very rapidly: not because of the spread of the disease, but through a reduction in the ATP needed to provide the energy required for the body to fight the disease. Without an adequate supply of energy, your body would rapidly fade.
By taking a D-ribose supplement that passes unchanged right into your bloodstream and taken to where it is needed most, you body can rapidly generate sufficient ATP to keep up the fight against the agent that is making you ill. Your immune system is given a massive energy boost, and more importantly, your heart is kept beating. D-ribose is the answer to the prayer of many sick people, and also to athletes and bodybuilders needing quick bursts of energy. But what did they use before D-ribose was discovered to have the properties that it has?
At one time, it was adenosine monophosphate (that’s right, not ATP or ADP, but AMP) that was administered intravenously to those suffering from chronic fatigue, this substance being synthesized to ATP in the body over a period of time. However, it take a lot of time to be effective, and the injections had to be made daily into the muscle tissue, so it fell out of favor.
Then came an ATP supplement that could be taken orally, but the side effects were unpleasant, and that too went out of favor. However, towards the end of the 1990’s D-ribose was found to overcome all of these disadvantages, and not only be able to be taken orally, but also to work almost immediately by providing the mitochondria with a direct source of the sugar they need to generate energy.
It is now one of the most popular energy providing supplements on the market, and also a remedy for chronic fatigue that helps the patient to overcome energy-sapping medical conditions both directly and by providing the immune system with the energy needed to keep it operating effectively against masses of invading bacteria and viruses. There is nothing better than D-ribose for providing you with the energy boost that you need, whenever you require it, either to provide energy for your sport or to help you overcome illness.
Power Your Day With Natural Energizer's
December 20, 2007 01:48 PM
If you tend to feel a bit tired now and again, there are plenty of natural energizers that you can use to power your day and provide you with that much needed energy to enable you to get going and keep going.
If you are suffering from chronic fatigue then you need something to get you going, and many people suffering from conditions such as fibromyalgia that can cause severe fatigue and very poor sleeping patters, need an energy booster each morning. It might not help the pain, but it will help their bodies to get moving and provide the energy required for everyday living.
So what substances are available to help you energize yourself for what the day is to bring you? The Chinese use cordyceps, which is type of mushroom that truly could be describes as ‘magic’. It grows on the caterpillars of a type of moth and can improve stamina and endurance, and also regulate sleeping patterns. It is useful for the prevention of depression, and improves the function of your lungs and also of the adrenal function. A low adrenal function can lead to low blood sugar and loss of energy.
Energy is obtained from the cellular mitochondria that metabolize blood glucose into energy. Part of this metabolic process requires the presence of adenosine triphosphate (ATP). Coryceps is known to increase the ATP levels in human cells and so enable the mitochondria to generate more energy. It is used in China by those recovering from surgery or childbirth, and is known to replace the energy lost after heavy exertion.
Its added benefits to those suffering from sexual dysfunction are well known, and it appears to promote stronger blood flow to the extremities of the body. In Chinese medicine it replenishes yin and yang jing and is also a strong antioxidant. It is used extensively by athletes and people who expend a lot of energy while working and exercising.
A magnesium deficiency is rare in the western diet, but it can cause symptoms including fatigue, weakness, irritability, muscle cramps, insomnia stress and appetite loss. Your cardiovascular system is dependent on magnesium for its functioning, and it contributes significant to the strength of the heart muscle contraction and hence the blood flow.
It is also an important component of bone, and during times of stress its stores can be significantly depleted. It is when stressed, then, that most people might benefit from a supplement, and a general energy boosting supplement would also benefit from a small amount of magnesium to replace what is lost through stress. Many people needing a tonic to give them a start to the day might also be under stress for one reason or another, and a magnesium supplement will do them no harm.
D-ribose is found in all living cells. It is an essential building block of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). DNA, of course, is essential to life while RNA is used in DNA replication. Ribose is responsible for providing energy to every cell in your body, and without it you would not exist. Athletes in particular believe that a ribose supplement increases stamina and endurance, and it is used to help speed up recovery of the heart after surgery and after heart attacks.
Ribose seems an excellent candidate to be included in any energizing tonic due both to its ubiquitous presence throughout the body and also because it is a sugar – a monosaccharide in fact, and hence simple and easily absorbed by the body.
Yohimbe is obtained from the bark of a predominantly West African tree, and when ingested it releases an indole alkaloid called yohimbine into the bloodstream.
Yohimbine is a vasodilator, which means that it widens the blood vessels allowing a greater flow of blood to the extremities. This is one reason why it is also prized by those suffering from erectile dysfunction although it also claimed to be an aphrodisiac. However, as an energizer it is likely the increased blood flow that provides a greater supply of oxygen to the muscles that is the most important property. There are also several more alkaloids contained in yohimbe bark that likely have an effect on its energy enhancing effects on the body.
Guarana is extracted from the seeds of the guarana shrub, native to South America, and Brazil in particular. The Amazonian natives use it in their food and drinks to improve their alertness and energy and its main benefits likely come from its caffeine content. This is about twice that of coffee beans, and it should therefore be used with caution.
An excess of caffeine can cause restlessness, tension and nervousness due both to the caffeine content (xanthines), and that of other alkaloids such as theophylline and theobromine. They not only enhance your alertness and energy levels but suppress appetite and increase your metabolic rate that results in an increased need for energy providing foods such as sugars. However, guarana is used by those needing a boost and makes a good energizer for those that find it difficult to keep both physically and mentally active throughout the day.
Bee products provide sugars in a natural form and are excellent and natural energizers for your whole body. Whether you use royal jelly, honey or any other of the bee products available as supplements, they will not only increase your energy levels but also provide you with many other health benefits.
From treating athlete’s foot to healing wounds and alleviating stomach ulcers, honey has many medicinal uses. It is an antioxidant and antiseptic, and can heal you of many conditions from head to toe, inside and out. Bee products are a must in any restorative or energizing tonic and are completely safe with no known side effects.
Each of the above six substances has its place as a natural energizer, and each could help to power your whole day. Put them together and you have an ultra-powerful mix of natural products that should enable you to meet any physical demands put on you. You are unlikely to come across such a combination of effective substances of course, but should make your choice of tonic from any or some of the above, and you can even use them in combination since they do not appear to interact with each other.
The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium
May 18, 2007 01:06 PM
The Awesome Foursome: Coenzyme Q10, L-Carnitine,
The “Awesome Foursome” of Coenzyme Q10, L-Carnitine, D-ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-Carnitine, D-ribose, and magnesium work in synergy to promote cardiovascular health.
Energy Recycling through the Electron Transport Chain
Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.
Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.
In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.
What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.
Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-Carnitine.
Transporting the Cellular Energy Fuel
Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-Carnitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-carnitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-carnitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-carnitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-ribose can do that.
Rebuilding the Cellular Energy Pool
As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-carnitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.
When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.
Ribose is the only compound used by the body to refill this energy pool. Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency. Ribose is made naturally in the cells from glucose. In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis. So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.
Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy. Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days. But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose. Conditions like ischemic heart disease or congestive heart failure fall into this category. In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.
Switching on the Energy Enzymes
Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism. Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work. Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is expanding.
Magnesium deficiency reduces the activity of important enzymes used in energy metabolism. Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function. Small changes in magnesium levels can have a substantial effect on heart and blood vessel function. While magnesium is found in most foods - particularly vegetables - deficiencies are increasing. Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.
Supporting the Links in The Energy Cycle Chain – the Synergy
Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.
The cell needs a large, sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-carnitine come into play.
The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-carnitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-carnitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-carnitine help the engine run properly.
Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.
These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-carnitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.
The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.
L-carnitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.
D-Ribose supplied by Bioenergy Life Science
April 19, 2007 02:44 PM
A UNIQUE SUGAR MAY BE KEY TO ENERGIZING THE FAILING HEART Bioenergy Life Science's D-ribose offers promising options for energy-deprived hearts
MINNEAPOLIS, MN, APRIL 18, 2007-Following the recent publication in the New England Journal of Medicine that the failing heart is an "engine out of fuel" (N ENGL J MED 356;11, March 15, 2007), Bioenergy Life Science reports that D-ribose, a simple, five-carbon sugar, is a plausible option for addressing the nation's heart disease epidemic.
"When heart failure develops, many factors are involved, but energy deprivation is among the most important," said John St. Cyr, MD, PhD, the medical director of Bioenergy Life Science. "We've learned recently that patients with heart disease may have a deficient supply of high energy compounds. Past studies have demonstrated that D-ribose supplementation enhances the return of ATP levels with an associated improvement in diastolic function."
D-ribose, unlike glucose, is a five-carbon sugar important for DNA, RNA, and most importantly, ATP, the "energy currency" of the cells. ATP is crucial in maintaining the integrity and function of every cell, which is necessary for day- to-day health. Ribose is one of the essential components of the ATP molecule.
D-ribose, as a supplement, has repeatedly shown to improve functional capacity, quality of life, and everyday activities for patients afflicted with congestive heart failure.
Dr. Neubauer's article, "The Failing Heart - An Engine Out of Fuel," calls attention to the important underlying metabolic problem in patients with heart failure. "D-ribose could aid in this metabolic deficiency," said Dr. St. Cyr. "The number of heart failure patients continues to grow every year. By replenishing ATP to an energy-deficient heart we can significantly improve a patient's quality of life."
D-Ribose Powder Benefits!
April 10, 2007 11:57 AM
Supports normal heart function*
A significant amount of in vitro, animal and human research suggests benefits of ribose on heart function.* Studies have shown that ribose supplementation can enhance cardiac energy levels and support cardiovascular metabolism.* Ribose has been shown in clinical trials to enhance the recovery of heart muscle ATP levels and improve myocardial function following exercise.
Studies suggest that ribose supplementation can increase the tolerability of the cardiovascular system to exercise-induced fatigue.1 In one study, twenty men underwent treadmill exercise tests on two consecutive days to confirm the onset of fatigue secondary to exercise. The participants were then randomized to the treatment group or a placebo group. The groups received either four doses of 15 grams of D-ribose (60 grams/day total) or the same amount of placebo each day. After three days of treatment, another treadmill test was performed. The time it took to reach the specified level of fatigue was significantly greater in the ribose group than in the placebo group.
Another study investigated the ability of ribose to support healthy heart function and quality of life.2 In a randomized, crossover design study, fifteen individuals were given 5 grams three times a day of either D-ribose or placebo. Each treatment period lasted three weeks. In patients receiving ribose, echocardiography demonstrated enhancement of heart function, reflecting a “more efficient relaxation phase of the heart”. Participants also had a significant improvement in their subjective quality of life scores compared to placebo.
Scientists suggest that suboptimal heart function is a result of the heart requiring more energy to function properly. Ribose supports the heart’s enhanced energy requirements, promoting optimal heart function. It does so by enhancing the stores of high-energy phosphates in heart tissue. These intermediates are necessary for the production and resynthesis of ATP. A double-blind crossover study in which 12 individuals were randomized to receive either ribose or dextrose (both administered as 5 grams three times daily for three weeks, followed by a 1-week washout period and crossover of treatments for three additional weeks) suggested significant enhancements in normal cardiac function during the period of ribose supplementation.3
Perhaps one of the more useful illustrations of the potential for ribose to support heart function comes from a study in which 20 rats received a continuous infusion of ribose for 24 hours (control rats received an infusion of saline). The hearts were then explanted (as they would be for heart transplants) and placed in preservation solution that was enriched with ribose for 4 hours. ATP levels were measured from tissue biopsies and revealed that 10 of the ribose-treated hearts had ATP levels higher than 12.3 micromoles per gram whereas saline-treated hearts (controls) had lower ATP levels, with 20% showing levels below 10 micromoles per gram of tissue. This provides support for the hypothesis that ribose may enhance the preservation of ATP levels in cardiac tissue, promoting normal heart function.4
Further animal studies have shown that ribose significantly enhances heart function after experimentally induced cardiac depression. Rats were injected with isoproterenol (a drug that stimulates sympathetic nervous system function) and had their abdominal aorta constricted to induce depression of heart function and reduce cardiac ATP levels. The decrease in ATP was primarily responsible for the depression of heart function. Continuous infusion of ribose for 24 hours replenished ATP concentrations to normal levels and normalized heart function in these animals.5
Ribose may strengthen and support the body’s crucial antioxidant defenses*
Ribose may support the body’s innate antioxidant mechanisms while promoting an antioxidant effect of its own. Intense exercise and other strenuous activity can induce the production of free radicals. Preliminary studies suggest that ribose can attenuate some of the effects of oxidation seen after performance of intensive exercise.
One small human study indicated that ribose administered at a dose of seven grams before and after a bout of cycling exercise may reduce free radical production.6 Seven volunteers ingested either ribose or placebo both before and after intense exercise. Markers of lipid peroxidation, including malondialdehyde, significantly decreased in the ribose-supplemented group, while increasing in the control group. The results of this study indicate a possible effect of ribose in supporting antioxidant activity.
Supports healthy energy levels in heart and muscle tissue*
After bouts of intense exercise, ATP levels have been shown to decrease by an average of 15 to 20%.7 The amount of ATP stored in the muscle is limited and so the body must have the potential to rebuild ATP stores. ATP is the fuel necessary for the integrity and function of a cell. In addition, several studies have found correlations between ATP content and heart function.1 Research that was also alluded to above suggests that ribose stimulates ATP synthesis and supports heart and muscle function by enhancing ATP levels in cardiac and muscle tissue. D-ribose is an essential building block for the synthesis of ATP through the pentose phosphate pathway.
The results of ribose supplementation enhancing ATP levels in muscle are evidenced by studies suggesting beneficial effects on anaerobic performance. In a randomized, placebo-controlled crossover study assessing the effects of acute ribose supplementation, participants receiving the ribose supplement had increases in mean power (a measure of average overall muscular strength output during the sprint) and peak power (a measure of the highest muscular strength output during the sprint) when undergoing a series of cycle sprints.8 While this effect was not noted in all of the six short cycling sprints that the participants underwent, the study does illustrate the potential benefits of ribose on ATP production and, secondarily, on enhancing exercise performance.
A second placebo-controlled trial investigated the effects of four weeks of ribose-supplementation (10 grams /day) on male bodybuilders. Of the 20 participants who were recruited, twelve completed the study. Each subject participated in a heavy-resistance training program designed to increase skeletal muscle mass. The effects of ribose on body composition (body weight, body fat, lean body mass, fat mass, and bone mineral content) were also assessed. The results suggested that ribose increased total work capacity and bench press strength compared to placebo, without altering body composition.9
Supports energy recovery after exercise*
Animal studies have suggested that the administration of ribose after exercise increases the rate of adenine salvage by five to seven-fold in muscle tissue7, supporting energy recovery after exercise. When ATP is utilized by muscle tissue, the degradation products include adenine nucleotides (Adenine is one of two purine bases that is a component of DNA). Adenine is recycled to synthesize DNA, and the salvage of adenine within the muscle tissue is crucial to energy recovery. Studies have shown that the presence of adequate ribose concentrations is the rate-limiting step in the purine salvage pathway. Therefore, increased adenine salvage could potentially help in the recovery and regeneration of ATP after intense bouts of activity.
A study investigated the effect of oral intake of ribose on the synthesis of AMP, a precursor to ATP.10 Participants performed intense cycle training for seven days. They then received either ribose (at a concentration of 200 mg/kg body weight, which is equivalent to 14 grams per day for an average 70 kilogram male) or placebo three times a day for the following three days. Exercise tests were performed again on day 4. Muscle biopsy samples were taken before the first training session, immediately after, and again five hours, 24 hours, and 72 hours after the last training session. No differences were seen in exercise performance between the groups. The intense exercise caused the ATP levels in muscle to decrease in both groups. However, at 72 hours post-exercise, the ribose group exhibited a much higher ATP level than the placebo group. The muscle levels of critical building blocks for ATP, including total adenine nucleotides (TAN) and inosine 5’-monophosphate (IMP), were also significantly higher in the ribose group compared to the placebo group at 24 hours after exercise. Ribose-supplementation was shown to enhance the resynthesis of ATP after intense exercise.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Caution: Insulin-dependent diabetics and pregnant women should consult their physician before use.
Suggested Adult Use: Take 1 or 2 scoops mixed in water, juice or other beverage two times per day. May be taken with or without food.
1) Pliml, W., von Arnim, T., Stablein, A., Hofmann, H., Zimmer, H., Erdmann, E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. The Lancet. 1992;340:507-510.
2) Omran, H., Illien, S., MacCarter, D., St. Cyr, J.A., Luderitz, B. D-ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. The European Journal of Heart Failure. 2003;5:615-619.
3) Illien, S., Omran, H., MacCarter, D., St. Cyr, J.A. Ribose improves myocardial function in congestive heart failure. FASEB Journal 2001;15(5): A1142
4) Muller C., Zimmer H., Gross M., Gresser U., Brotsack I., Wehling M., Pliml W. Effect of ribose on cardiac adenine nucleotides in a donor model for heart transplantation. Eur J Med Res. 1998 Dec 16;3(12):554-8.
5) Zimmer H.G. Normalization of depressed heart function in rats by ribose. Science. 1983 Apr 1;220(4592):81-2.
6) Seifert, J.G., Subudhi, A., Fu, M., Riska, J.J. The effects of ribose ingestion on indices of free radical production during hypoxic exercise. Free Rad Biol Med 2002; 33(Suppl 1) S269.
7) Zarzeczny, R., Brault, J.J., Abraham, K.A., Hancock, C.R., Terjung, R. Influence of ribose on adenine salvage after intense muscle contractions. J Applied Physiology. 2001;91:1775-1781.
8) Berardi J.M., Ziegenfuss T.N. Effects of ribose supplementation on repeated sprint performance in men. J Strength Cond Res. 2003 Feb;17(1):47-52.
9) Van Gammeren, D.V., Falk, D., Antonio, J. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo-controlled trial. Current Ther Research. 2002;63(8):486-495.
10) Hellsten, Y., Skadhauge, L., Bangsbo, J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. 2004;286:R182-R188.
Buy Ribose at Vitanet at a Discount
Battle Fatigue! Don't passively accept chronic exhaustion and weakness.
June 10, 2005 10:06 PM
Battle Fatigue! Don't passively accept chronic exhaustion and weakness. by Joanne Gallo Energy Times, December 6, 1999
Most folks wouldn't seek the distressing distinction of suffering chronic fatigue syndrome. Aside from a dizzying array of discomforts associated with the malady, the lack of a definitive cause, and few remedies offered by the medical establishment, scornful skeptics lob accusations of laziness or boredom or just plain moodiness. "Snap out of it!" they say, with little sympathy or understanding. "Just get moving!"
But if you're one of more than 3 million Americans affected by chronic fatigue, you know your problem is not all in your head. Your symptoms are real and they extend far beyond mere tiredness. In addition to a debilitating sense of fatigue that can make everyday existence feel like an overwhelming struggle, you may suffer from impaired concentration and memory, recurrent sore throats, nagging headaches, muscle and joint pain, swollen lymph nodes and fitful sleep. The persistence of any one of these effects alone could be debilitating, but the overall diminished capabilities of the chronic fatigue sufferer can become the most discouraging aspect of the disease.
But before you give up hope on kicking this energy-sucking ailment, look to natural ways to boost your immune system and regain your stamina for a more healthy and productive life. New research points to powerful, energy enhancing supplements which, combined with a nutritious diet and stress reducing techniques, can help you reclaim your body from a swamp of sluggishness.
Part of the public's misconceptions about chronic fatigue syndrome (CFS) may stem from vague definitions of exactly what it is and its causes.
In the '80s, CFS was often mentioned in the same breath as the Epstein-Barr virus, which garnered much notoriety as the "yuppie flu": a state of chronic exhaustion that often plagued young, overworked professionals, as the media trumpeted. CFS was initially thought to be the result of the Epstein-Barr virus, and the two were often considered to be the same thing. Since the Epstein-Barr virus causes mononucleosis, the term "chronic mono" was also thrown around to refer to long-lasting states of fatigue.
Today, CFS is defined as a separate disorder from the Epstein-Barr syndrome. Researchers have found that CFS is not caused exclusively by the Epstein-Barr virus or any other single infectious disease agent. According to the Centers for Disease Control (CDC) in Atlanta, CFS may have multiple causes, in which viruses or other infectious agents might have a contributory role. Some of these additional possible culprits include herpes simplex viruses, candida albicans (yeast organisms), or parasites.
According to the CDC, a person can be definitively diagnosed with CFS when she or he experiences severe chronic fatigue for six months or longer that is not caused by other medical conditions, and must have four or more of the following problems recurrently for six consecutive months: tender lymph nodes, muscle pain, multi-joint pain without swelling or redness, substantial impairment in short-term memory or concentration; sore throat, headaches, unrefreshing sleep and postexertional malaise lasting more than 24 hours.
Even if you are not diagnosed with CFS, you could still probably use some help in fending off fatigue. You may suffer from another poorly understood condition like fibromyalgia, which causes similar symptoms of exhaustion and pain with additional stomach discomfort. You may cope with another ailment like hypoglycemia or low thyroid function that zaps your energy. Or you could be like almost every stressed-out American adult trying to do it all at the expense of your well-being. Though researchers still search for a definitive cause for CFS, one thing is certain: Constant stress and poor nutritional habits weaken the immune system's ability to ward off a host of debilitating viruses and organisms. So before you run yourself down and succumb to a chronic condition, learn how you can build up your defenses now.
Some of the most exciting new research in CFS treatments focuses on NADH or Coenzyme 1, an energy-enhancing nutritional supplement. This naturally-occurring substance is present in all living cells including food, although cooking destroys most of it. Coenzymes help enzymes convert food and water into energy and NADH helps provide cellular fuel for energy production. It also plays a key role in cell regulation and DNA repair, acts as a potent antioxidant, and can reportedly improve mental focus and concentration by stimulating cellular production of the neurotransmitters dopamine, noradrenaline and serotonin.
A recent study conducted at Georgetown University Medical Center in Washington, DC, and reported in the February 1999 issue of The Annals of Allergy, Asthma & Immunology, showed that chronic fatigue sufferers improved their condition significantly by taking Enada, the stabilized, absorbable, oral form of NADH. The researchers found that 31% of those who took the supplement achieved significant improvement in relief of their symptoms, and a follow up study showed that 72% achieved positive results over a longer period of time.
Coenzyme-A and Coenzyme Q-10 (Co-Q10) are related coenzymes also necessary for energy production.
According to Erika Schwartz, M.D., and Carol Colman, authors of Natural Energy: From Tired to Terrific in 10 Days (G.P. Putnam's Sons) CoQ10 in combination with the nutrient carnitine enhances cellular energy production, thereby boosting energy levels. Coenzyme-A is required to initiate the chemical reactions that involve the utilization of CoQ10 and NADH for the production of energy at the cellular level.
Another important energy-enhancing nutrient is D-ribose, a simple sugar that is crucial to many processes in your body. D-ribose stimulates the body's production of adenosine triphosphate, or ATP, an energy-rich chemical compound that provides the fuel for all body functions. D-ribose is essential to the manufacture of ATP and maintaining high levels of energy in the heart and skeletal muscles.
In addition to these new nutrients, a host of more familiar vitamins and minerals can help banish fatigue. According to Susan M. Lark, M.D., author of the Chronic Fatigue Self Help Book (Celestial Arts) nutritional supplements help stimulate your immune system, glands and digestive tract, promote proper circulation of blood and oxygen, and provide a calming effect. Some of Lark's recommended nutrients for building and regaining strength include:
Vitamin A: Helps protect the body against invasion by viruses that could trigger CFS, as well as bacteria, fungi and allergies. Supports the production and maintenance of healthy skin and mucous membranes, the body's first line of defense against invaders. Also supports the immune system by boosting T-cell activity and contributing to the health of the thymus, the immune-regulating gland.
Vitamin B Complex: Depression and fatigue can result from the body's depletion of B vitamins, which can occur from stress or drinking too many caffeinated beverages. Studies have provided preliminary evidence that CFS patients have reduced functional B vitamin status (J R Soc Med 92 , Apr. 1999: 183-5). The 11 factors of B complex are crucial to glucose metabolism, stabilization of brain chemistry and inactivation of estrogen, which regulate the body's levels of energy and vitality. n Vitamin C: Helps prevent fatigue linked to infections by stimulating the production of interferon, a chemical that can limit the spread of viruses. Helps fight bacterial and fungal infections by maintaining healthy antibody production and white blood cells. Also necessary for production of adrenal gland hormones which help prevent exhaustion in those under stress.
Bioflavonoids: Help guard against fatigue caused by allergic reactions; their anti-inflammatory properties prevent the production of histamine and leukotrienes that promote inflammation. Bioflavonoids like quercetin are powerfully antiviral.
Vitamin E: Has a significant immune stimulation effect and, at high levels, can enhance immune antibody response.
Zinc: Immune stimulant; improves muscle strength and endurance. Constituent of many enzymes involved in metabolism and digestion. n Magnesium and Malic Acid: Important for the production of ATP, the body's energy source. Magnesium is also important for women who may develop a deficiency from chronic yeast infections.
Potassium: Enhances energy and vitality; deficiency leads to fatigue and muscle weakness.
Calcium: Combats stress, nervous tension and anxiety.
Iodine: Necessary to prevent fatigue caused by low thyroid function, as it is crucial for the production of the thyroid hormone thyroxin.
In addition to nutrients to bolster your immunity, herbal remedies can also help suppress viral and candida infections. Garlic is a powerful, natural antibiotic, while echinacea and goldenseal have strong anti-infective abilities. Other botanicals help combat tiredness and depression: stimulating herbs such as ginger, ginkgo biloba, licorice root and Siberian ginseng can improve vitality and energy. For anxiety, moodiness and insomnia try passionflower or valerian root, which both have a calming effect on the central nervous system.
Eating For Energy
Supplements can only do their best if you eat a nutritious diet. Start by cutting out large quantities of sugar, caffeine, alcohol, dairy products, red meat and fat.
But what are the best foods when trying to restore energy or recover from illness? "High nutrient content foods with a good balance of proteins and carbohydrates," answers Jennifer Brett, ND, interim clinic director and chair of botanical medicine at the University of Bridgeport College of Naturopathic Medicine.
"You want foods with high nutritional value-that's where vegetables end up looking better than fruit."
Brett enthusiastically pushes that "universal food," as she calls it: chicken soup.
"In China," she says, laughing, "they do make chicken soup, and they do think of it as healing, because they add astragalus and shiitake mushrooms. Vegetable soups with chicken or fish have high nutritional value and are easy to digest."
The same principle applies to juices, Brett says. Juices are a good way to tastefully get more phytonutrients from fruits and vegetables into your diet. Toss in protein powder, and you can make a complete meal in your blender.
"You get more energy from juicing," she explains, "more accessible nutrients and carbohydrates that are not bound up in fiber." Brett's additional recommendation: oatmeal.
"It's got protein and carbohydrates combined with a lot of minerals, which you may not get from a sugary cereal," she says. "Sure, they spray some vitamins on them, but if you don't drink the milk in the bottom of the bowl, you'll miss out on them. You might as well take a multivitamin."
Look to fiber for superior energy enhancement. Natural Energy author Schwartz calls it downright "miraculous": "In terms of conserving precious energy, fiber-rich foods are your cells' best friends," she writes. "It takes smaller quantities of them to give you a full, satisfied feeling. They release all their benefits slowly, which allows the cells to extract nutrients with much less effort. Then these fiber-rich foods graciously leave the body with ease and efficiency." Among these "slow burn" foods that Schwartz says raise blood sugar slowly and steadily and maintain energy evenly:
Alfalfa sprouts-high in fiber and low in cholesterol.
Apples-one medium unpeeled provides 10% of the recommended daily fiber dose; unlike sweeter fruits, which are rich in healthful fiber, they help regulate blood sugar.
Broccoli-along with such greens as cauliflower, cabbage, kale, collard greens and broccoli rabe, it's packed with fiber, vitamins and minerals n Brown rice, wild rice, other whole grains-fiber treasure troves, including barley, quinoa, millet and buckwheat.
Corn-excellent fiber source.
Lentils and other legumes-high in fiber, delicious beans are rich in culinary possibilities.
Oat bran and wheat bran-mix into yogurt or add to cereal for the best available access to fiber.
Popcorn-an excellent snack.
Citrus for More Energy
If constant colds and infections are draining your energy, healthy helpings of citrus fruit may be the pickup you need. According to Robert Heinerman, in Heinerman's Encyclopedia of Healing Juices (Parker), citrus fruit have been used for more than a thousand years as natural remedies for a wide variety of ailments:
Kumquat juice is supposed to help clear up bronchitis. Lemon juice with a pinch of table salt eases a sore throat. Lime juice in warm water soothes aches and cramps from the flu. Tangerine juice can break up mucous congestion in the lungs. Along with citrus' vitamin C, these fruits also supply carotenoids, antioxidants that provide disease-preventing benefits. Citrus also often contain calcium, potassium, folate (a B vitamin that fights against heart disease), iron and fiber.
Fruits are loaded with phytochemicals, naturally occurring chemicals that give fruit their vibrant colors. Yellow, red and orange fruits are also high in flavonoids, like quercetin, a substance which fights cancer. Quercetin also aids in prevention of cataracts and macular degeneration, according to author Stephanie Beling, MD, in her book Power Foods (Harper Collins).
Even the US Department of Agriculture agrees on this flavonoid's benefits, noting in its phytochemical database that quercetin is an "antitumor promoter, antiasthmatic, anticarcinogenic, antiplaque, cancer-preventive, capillariprotective." (Quercetin is also available as a supplement.)
Don't Avoid Avocados
For a vitamin rich food, few items beat the avocado which holds vitamins E and C as well as some B vitamins (B6, niacin, riboflavin). A significant source of beta carotene, though not nearly as much as carrots or sweet potatoes, avocados also contain high amounts of the minerals potassium, magnesium, copper and zinc.
Just 15 grams of avocado delivers about 81 international units of vitamin A as beta carotene. Beta carotene, a carotenoid in fruits and vegetables, is converted to vitamin A in the body. This vitamin, aside from providing antioxidant protection from damaging free radicals, is necessary for good eyesight, healthy skin and healing.
In addition, the avocado, like all of these healthy foods, tastes great. Which means that you can pep up and not have to sacrifice taste for zest.
Healthy Mind, Healthy Body
Remember that the path to wellness begins in your mind. Stress-reducing activities like yoga, meditation and massage and aromatherapy can have a great rejuvenating effect on your body. If you can learn to handle stress effectively instead of letting it control you-and strengthen your system with the right nutrients and diet-you'll find that fatigue can be a sporadic visitor rather than a chronic companion.