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How much omega-3 should you take each day? Darrell Miller 3/27/19
Want to be smarter and have a better memory? Eat foods rich in this Darrell Miller 12/30/16
Even teethers labeled BPA-free may contain hormone-disruptors Darrell Miller 12/26/16
6 Vitamins And Minerals That Boost Brain Power - Medical Daily Darrell Miller 11/28/16
Pain Relief Darrell Miller 6/13/08
Are You At Risk And What Can You Do About It? Darrell Miller 4/23/08
California Proposition 65 (Prop 65) and Progesterone Cream Warnings Darrell Miller 2/17/06
Muscle Mass - Reach Your Maximum Muscle Potential Darrell Miller 6/4/05
KudZu, Treatment of alcohol dependence or alcohol abuse Darrell Miller 5/19/05
L-Tryptophan 500mg Darrell Miller 5/13/05




How much omega-3 should you take each day?
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Date: March 27, 2019 10:28 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: How much omega-3 should you take each day?





Many of us are well aware of the benefits surrounding omega-3 fatty acids, but exactly how much should we take on a routine basis in order to experience the most potent advantages? To receive benefits such as improved heart health, enhanced cognitive function, and inflammation reduction, people should be consuming 250 grams each day. This recommendation excludes pregnant women and children who should have around 300 grams each day due to their brains still being at a developmental milestone.

Key Takeaways:

  • Omega-3 fatty acids provide health benefits such as improving brain function, strengthening immunnity, and reducing the risk of heart diseases.
  • The 3 types of omega-3 fatty acids are Docosahexaenoic acid (DHA), Alpha-linolenic acid (ALA), and Eicosapentaenoic acid (EPA).
  • Some health organizations recommend taking 250 to 500 mg of EPA and DHA each day for maximum health benefits.

"DHA is essential for the eyes, brain and sperm cells. EPA is beneficial in reducing inflammation in the body."

Read more: https://timesofindia.indiatimes.com/life-style/food-news/how-much-omega-3-should-you-take-each-day/articleshow/67672802.cms

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Want to be smarter and have a better memory? Eat foods rich in this
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Date: December 30, 2016 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Want to be smarter and have a better memory? Eat foods rich in this





According to a study by the University of Illinois, eating foods rich in lutein like many leafy greens and cruciferous vegetables, for example, will help promote a healthy aging brain. The study did not specify the amount of lutein that is needed for ultimate brain protection and only concluded that more levels of the vitamin meant a better chance at brain health preservation. If your brain health is poor, Collingridge says it could lead to other serious neurological conditions like developmental disorders right through to dementia.

Key Takeaways:

  • Research also shows that lutein accumulates in the grey matter of brain regions known to underlie the preservation of cognitive function in healthy brain again.
  • The University of Illinois study looked at 122 healthy people between the ages of 65 and 75. They were asked to solve problems and answer questions on a standard test of crystallized intelligence.
  • The study did not specify the amount of lutein that is needed for ultimate brain protection and only concluded that more levels of the vitamin meant a better chance at brain health preservation.

"Smoking can cause illnesses that contribute to memory loss, including stroke and hypertension. Smoking also constricts the blood vessels to the brain, depriving it of oxygen and possibly harming neurons."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.newstalk770.com/syn/123/26315/26315&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNESxHH5S1J4AycwHpsmiBf7YG9eNg

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3720)


Even teethers labeled BPA-free may contain hormone-disruptors
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Date: December 26, 2016 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Even teethers labeled BPA-free may contain hormone-disruptors





A recent report in the journal Environmental Science and Technology states that 59 different teething devices they tested all came up positive for BPA, which is a known endocrine-disrupting chemical. They also found other dangerous chemicals present in some, but this is one of the most concerning. These chemicals disrupt normal hormone function and can cause abnormal growth and development in children. The real problem is that all of the products were marked as BPA-free. Obviously, stronger measures need to be put in place to make sure companies are properly advertising their products.

Key Takeaways:

  • Some baby teething toys marketed as non-toxic might contain chemicals that could interfere with hormones involved in normal growth and development, a study suggests.
  • All of the products tested positive for one such chemical, bisphenol-A (BPA), even though most of the teethers were marketed as BPA-free, researchers report in the journal Environmental Science and Technology.
  • In animal studies, endocrine-disrupting compounds such as BPA, parabens and antimicrobials have been shown to interfere with hormones and have harmful developmental, reproductive and neurological effects.

"In lab tests for the current study, researchers found BPA as well as a range of different parabens and the antimicrobials triclosan and triclocarban in most of the teethers."



Reference:

https://www.yahoo.com/news/even-teethers-labeled-bpa-free-may-contain-hormone-193030007.html?ref=gs

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3704)


6 Vitamins And Minerals That Boost Brain Power - Medical Daily
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Date: November 28, 2016 06:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 6 Vitamins And Minerals That Boost Brain Power - Medical Daily





Every day, we understand more and more about how the human body works. No other organ has required more research than the brain. It is a highly complex organ that uses a balance of essential vitamins and minerals to function properly. If you want your body to perform at its best and help prevent neurological disorders, consuming the proper amount of vitamins such as thiamine, folic acid, and vitamin C is very important. Calcium, magnesium, and zinc are the main minerals that are very important for brain function.

Key Takeaways:

  • Nutritional deficiencies have been shown to contribute to the development of psychiatric disorders, age-related cognitive decline, and developmental disorders.
  • On the other hand, both human and animal studies show that increased intake of brain-supporting nutrients improve various aspects of cognitive functioning such as learning and memory.
  • Scientists don’t know what role zinc plays in the maintenance of brain health, but its deficiency is associated with different neurological and psychological impairments.

"Nutritional deficiencies have been shown to contribute to the development of psychiatric disorders, age-related cognitive decline, and developmental disorders."



Reference:

//www.medicaldaily.com/6-vitamins-and-minerals-boost-brain-power-396091

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Pain Relief
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Date: June 13, 2008 12:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pain Relief

DL-Phenylalanine has been found to work in conjunction with the body’s natural ability to relieve pain. It helps to lengthen the lifespan of the chemicals in the brain that ease pain. It is especially effective in relieving pain from arthritis and aching muscles.

Some chronic pain can be treated with DL-phenylalanine through the stimulation of nerve pathways in the brain that control pain. Enhanced pain relief has been discovered when D-phenylalanine is used in conjunction with prescribed pain killers. This manufactured form of phenylalanine is used to block an enzyme in the nervous system that increases pain signals. The interruption of pain signals allows the healing mechanisms of the body to begin working faster.

DL-Phenylalanine is a chemical combination of half L-phenylalanine and half D-phenylalanine. L-Phenylalanine is the natural form of phenylalanine found in proteins all over the body. It is found in foods like beef, poultry, pork, fish, eggs, milk, yogurt, cheese, nuts, seeds and certain soy products. D-Phenylalanine is a synthesized form of the chemical, which means it is produced in a laboratory.

Phenylalanine as an Amino Acid:

Amino acids perform various major functions in the body. They assist in fulfilling the body’s basic needs from minerals and vitamins. They can act as neurotransmitters, which carry signals to and from the brain. They also aid in other parts of the body for communication between nerve cells.

Phenylalanine is one of the essential amino acids found in protein. This means it is required for human health, but cannot be manufactured by the human body. Therefore it has to be supplied through food consumption. It can also be found and taken in the form of powder, capsule, tablet or a topical cream. In the body, phenylalanine is converted into tyrosine, which is another amino acid needed to make protein. It is also needed to make certain brain chemicals and thyroid hormones. Phenylalanine deficiency signs include:

* Confusion
* Decreased alertness
* Lack of energy
* Diminished appetite
* Decreased memory

Phenylalanine Warnings:

A rare disorder called phenylketonuria (PKU) happens in humans who are missing the enzyme required to metabolize phenylalanine. Symptoms of this disorder tend to appear between the ages of 3-6 months. These include:

* Eczema
* Developmental delay
* Abnormally small head circumference
* Hyperactivity

If PKU is not treated within the first three weeks of life, it can cause severe and irreversible mental retardation. Women who are pregnant or nursing should avoid taking phenylalanine as a supplement in any form. DL-Phenylalanine may cause hyperactivity, jitteriness and anxiety in children.

Phenylalanine is the major ingredient in the artificial sweetener known as aspartame. Products containing this sweetener are required by law to carry warnings on their labels for phenylketonurics. People who have PKU can be severely injured by ingesting the sweetener. Products containing this artificial sweetener include diet sodas, sugarless gums and some sugar substitutes. Some sugar-free versions of Jello, puddings, ice creams, candies and various other items also contain aspartame.

Other Phenylalanine Uses:

Some individuals have reported that taking DL-phenylalanine has improved their mood and aided in treating depression. This is the result of a higher rate of production of the brain chemicals dopamine and norepinephrine. These chemicals, when out of balance, cause depression, stress and frustration. Elevation of the levels of these chemicals have an anti-depressant effect in the body.

One study suggests that D-phenylalanine has been shown to improve some symptoms associated with Parkinson’s disease. These include: depression, rigidity, walking problems and speech problems.

The combination of L-phenylalanine and UVA radiation may be used to treat the symptoms of vitiligo. This condition involves de-pigmentation (white patches) of skin. The use of L-phenylalanine may help to re-pigment these patches, but further study is necessary.

DL-Phenylalanine has many uses and benefits if taken correctly. As with any new dietary supplement, consult your physician before beginning a new routine.



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Are You At Risk And What Can You Do About It?
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Date: April 23, 2008 04:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Are You At Risk And What Can You Do About It?

Did you know there are Persistent Organic Pollutants (POPs) that can have an endocrine disrupting ability? Meaning, these chemicals can have an estrogen like and anti-androgen effect on the body, disrupting the normal function of our endocrine system which can cause all sorts of health issues.

Back in the industrial boom directly following world war II these chemicals were widely used in plastics, cosmetics, personal care products, cleaning agents, clothing, household furnishings, and decorations, food and water, fertilizers, and pesticides and fungicides. These chemicals are being banned by the government but are not gone all together yet.

Endocrine disruptor chemicals are fat soluble which means when consumed they are stored by the body in our fat stores. This makes these chemicals a persistent pain in the butt for a very long time since fat soluble substances tend to be stored and slowly released; some claim the release can be years and years down the road.

These types of toxins can easily leach into water including juices and can vaporize into the air that we breathe in to our lungs. Once ingested, these chemicals can lead to reproductive, developmental, behavioral, neurological, endocrine, and immunologic adverse health effects that can last a lifetime.

Those men and women who want to have children may discover that one of both at have reproductive impairments due to POPs. Symptoms of toxicity are male infertility, gynecological problems, and accelerated puberty, developmental abnormalities of the reproductive tract, premature delivery, behavioral problems, abnormal thyroid function, cancer and heart disease. In cases of children, signs of toxicity are leukemia when fetal exposure is experienced.

The wide spread use of phthalates in industrial and consumer products has raised a lot of concerns. Phthalates are what keep plastics flexible. Dibutyl phthalate is used in PVC piping (in new homes the piping that supply water to faucets), various varnishes and lacquers, safety glass, nail polishes, paper coatings, dental materials, pharmaceuticals, children’s toys, and plastic food wrap. The heating of plastic containers either by microwave or a hot cup of tea can easily leach these phthalate’s in to food or drink exposing humans to high amounts of this toxin.

Also, Parabens are high on the watch list for those health minded. Parabens are a group of synthetic chemicals used as a preservative in cosmetic and pharmaceutical products. The most common parabens are methylparaben, propylparaben, and butylparaben. These three are used as a bacteriocidal and fungicidal agent in many products we use every day. The FDA does not require approval of cosmetic ingredients before they reach the market place so cosmetic manufactures are free to use what ever they want in their products.

Parabens have been shown to have a mild estrogenic affect on the body, and are in practically all personal care products on the market today. If you are applying a name brand cosmetic onto your skin daily, take a look at the label to see if Parabens are used.

For those looking to stay away form all the above listed toxins look for products packaged in glass, PETE or HDPE bottles and containers. Look for packets lined with saran, and can linings made of polyolefins. Use biodegradable household cleaning agents and avoid sprays and insecticides. Cleaning supplies are not required to list ingredients so it is always buyer beware unless the label states it is free from PCBs, Parabens, and POPs.

Finally, when buying furniture avoid furniture that contains flame retardant PBDEs and limit children to the exposure of such furniture. Exposure to PBDEs can lead to some of the above listed symptoms and cause health problems. Staying healthy is a tough task with all the environmental toxins we face. By buying organic foods and avoid the above listed chemicals one can live longer and maintain better health over a lifetime.

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California Proposition 65 (Prop 65) and Progesterone Cream Warnings
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Date: February 17, 2006 06:29 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: California Proposition 65 (Prop 65) and Progesterone Cream Warnings

Scientific Safety Information on Progesterone

California Proposition 65 (Prop 65) and Progesterone Cream Warnings Amy Kosowski, M.S., LDN

Prop 65: What is it?

Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986 , was enacted as a ballot initiative in the state of California in November of 1986. The Proposition was intended by its authors to protect California citizens and the State's drinking water sources from chemicals known to cause cancer, birth defects or other reproductive harm, and to inform citizens about exposures to such chemicals 1.

Proposition 65 requires the Governor to publish, at least annually, a list of chemicals “known to the state to cause cancer or reproductive toxicity .” Progesterone, as well as other human hormones, appear on this list 1. Set forth below is the information that formed the bases for the addition of progesterone to the Prop 65 list by the California Office of Environmental Health Hazard Assessment (“OEHHA”).

Prop 65 and Progesterone - Perspective

In August of 2004, OEHHA published a document stating the rationale for the addition of Progesterone to the Prop 65 list 2. This document is a review of human, animal, and in vitro studies that used progesterone, synthetic progestins, and other progestagens (progesterone-like compounds). Experimental data from the use of all of these compounds were mixed together, along with data from studies using other steroid hormone derivatives (mainly synthetic estrogens) and many different methods of administration.

Although this review covered the existing scientific literature on progesterone and its many derivative compounds, there are many problems with the type of data analysis that was employed.

First, progesterone is endogenous to humans and necessary for bone and reproductive health while progestins and other synthetic progestagens are not. Progestins and progestagens are similar in molecular structure to progesterone, but when they bind to progesterone receptors, their effects are usually much stronger and more likely to cause abnormal physiologic responses 3, 4. Furthermore, the majority of the studies concerning the health effects of these progesterone derivatives involved combinations with synthetic estrogens 2-4.

There were very few studies mentioned in the 2004 document that used exclusively bio-identical progesterone (the kind found normally produced by humans as well as that used in progesterone creams), and those studies that did were at supra-physiologic doses (very high). The doses of progesterone ranged from 10-1000 times the dose usually recommended by manufacturers of progesterone creams 2, although in a few cases, the doses were closer to the recommended dosages.

The route of administration of progesterone is also at issue. All of the studies cited in the OEHHA document used either oral, injected, or suppository forms of hormones; none was conducted using transdermal creams. This is an important consideration because hormones absorbed through the skin are metabolized differently than hormones that are administered via other routes 5, 6.

Putting it Together

While the OEHHA Prop 65 reference document on progesterone 2 is a broad survey of the published scientific literature examining the potential effects of the pharmaceutical use of progesterone and its synthetic derivatives, it is not clear at all that these effects would be seen with the use of low-dose progesterone creams.

The OEHHA Prop 65 progesterone document evaluates a broad range of information regarding progesterone and synthetic materials that are not natural progesterone. The conclusion reached was not challenged, and it is on that basis that progesterone creams now carry the Prop 65 warning.



References:

1 California OEHHA Web Site: //www.oehha.ca.gov/prop65/p65faq.html .

2 Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency (2004) Evidence on the developmental and Reproductive Toxicity of Progesterone.

3 Campagnoli C, Abba C, Ambroggio S, Peris C (2005) Pregnancy, progesterone and progestin in relation to breast cancer risk. J Steroid Biochem Mol Biol 97(5):441-450.

4 Campagnoli C , Clavel-Chapelon F , Kaaks R , Peris C , Berrino F (2005) Progestins and progesterone in hormone replacement therapy and the risk of breast cancer. Steroid Biochem Mol Biol 2005 96(2):95-108.

5 de Lignieres B, Dennerstein L, Backstrom T (1995) Influence of route of administration on progesterone metabolism. Maturitas 21:251-257.

6 Gompel A, et al. (2000) Progestins were also proapoptotic in normal as well as in hormone-dependent breast cancer cells. Steroids 65(10-11):593-598.

7 Bu SZ ( 1997) Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines. Cancer 79(10):1944-50.

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Muscle Mass - Reach Your Maximum Muscle Potential
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Date: June 04, 2005 09:49 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Muscle Mass - Reach Your Maximum Muscle Potential

The serious athletes of today know how much it takes to fulfill their competitive goals: careful training, a strong will, and also the right kind of nutrition. Sports science now makes available key nutrients which help assure that strenuous workout regimes will show results. Results that are both nutritionally sound and dramatically visible, without the need for dangerous steroids or chemicals. MUSCLE MASS™ is such a state-of-the-art sports science formula.

THE PURPOSE OF MUSCLE MASS ™ is to help translate distant goals for greater strength and power into quicker, awesome reality. It is the premier formula combining all essential nutrients known to maximize muscle development and optimize strength.

  • • Gamma Oryzanol: This safe, natural rice bran extract, heavily researched in Japan since the 1950s, is rightfully winning raves among athletes who have discovered its startling developmental properties.
  • • Ornithine: Celebrated by the Life Extension and Eat to Win books, this free-form amino acid also has noticeable building effects, and in addition, adds tone and definition to the results.
  • • Lipotropic Factors: Helping to turn excess fats into energy quickly are LCarnitine, L-Methionine, Choline, and Inositol.
  • • Branched Chain Amino Acids: L-Leucine, L-Isoleucine, and L-Valine protect muscles during stressful exertion by providing extra nitrogen and energy.
  • • Special Herbs: Chosen from both the American and Chinese herbal traditions for their building and energizing qualities are Saw Palmetto, Ginseng, and others.
  • • Co-Nutrients: For the oxygenating, transporting and catalyzing contributions are included Glycine, B-5, B-6, Betaine, and Licorice Root.

    In sum, all these balanced, cutting-edge factors combine to assist you in meeting the challenges you’ve set for your body. Power, endurance, strength, tone, and the winner’s circle are now closer.



    VitaNet ®
    VitaNet ® Staff

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    KudZu, Treatment of alcohol dependence or alcohol abuse
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    Date: May 19, 2005 09:29 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: KudZu, Treatment of alcohol dependence or alcohol abuse

    For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested to date.

    Alcohol abuse

    Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense.

    While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts.

    Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula:

    CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH

    In addition, our studies more recently have focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula:

    CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH

    Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual differences in alcohol tolerance might well be based on both qualitative and quantitative differences in isozyme endowment (Vallee, 1966, supra).

    Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.

  • Kudzu Recovery 60ct

  • Kudzu Recovery 120ct

  • Kudzu Root Extract 50caps

  • Kudzu Root Extract from Solaray 60ct



  • Recover from stress, lessen desire for alcohol, primary cleansing, and liver support


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    L-Tryptophan 500mg
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    Date: May 13, 2005 06:45 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: L-Tryptophan 500mg

    L-5-Hydroxytryptophan treatment of sleep terrors in children.

    Bruni O, Ferri R, Miano S, Verrillo E.

    Centre for Paediatric Sleep Disorders, Department of Developmental Neurology and Psychiatry, University of Rome "La Sapienza", Via dei Sabelli 108, 00185 Rome, Italy. oliviero.bruni@uniroma1.it

    To test the hypothesis that the administration of L -5-hydroxytryptophan (L -5-HTP) might exert beneficial effects on sleep terrors, we carried out an open pharmacological trial in a group of children with sleep terrors compared to a group of children with the same disorder but without L -5-HTP treatment. Participants in the trial were 45 children (34 males and 11 females; age range 3.2-10.6 years), referred to the Sleep Centre of the Department of Developmental Neurology and Psychiatry of the University of Rome "La Sapienza", affected by sleep terrors. All subjects underwent: (1) complete medical and sleep history; (2) complete neurological examination and EEG recording whilst awake and sleeping, (3) a structured sleep diary for 2 months, (4) after 1 month, all subjects were examined again from the clinical and EEG points of view and (5) after 6 months, a structured interview in order to evaluate the clinical outcome. After the first visit, L -5-HTP was administered (2 mg/kg per day) at bedtime to 31 randomly selected patients for a single period of 20 consecutive days. After 1 month of treatment, 29/31 (93.5%) of patients showed a positive response. In the comparison group without drug therapy, after 1 month, the episodes disappeared only in four children (28.6%) while ten children (71.4%) showed the persistence of episodes with the same frequency as before. After 6 months, 26/31 (83.9%) of children treated with L -5HTP were sleep terror-free, while in five children (16.1%) sleep terror episodes persisted. Of the children in the comparison group, ten (71.4%) continued to show sleep terrors at 6-month follow-up. CONCLUSION:to our knowledge, this is the first study demonstrating the efficacy of a new drug treatment for sleep terrors. These results confirm our initial hypothesis and represent evidence that treatment with L -5-hydroxytryptophan is able to modulate the arousal level in children and to induce a long-term improvement of sleep terrors. Copyright 2004 Springer-Verlag

    Publication Types:

  • Clinical Trial
  • Randomized Controlled Trial


  • L-Tryptophan 500mg 90ct


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