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L-Cysteine Darrell Miller 5/8/09
Bird Flu Vaccine in short supply !! Darrell Miller 11/26/05
Red Yeast Rice For Lipid Wellness Darrell Miller 6/4/05




L-Cysteine
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Date: May 08, 2009 10:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Cysteine

L-Cysteine is what is known as a non-essential amino acid, meaning that it can be biosynthesized by the body and hence not an essential part of your diet. Due to its possessing a thiol side chain, it is termed a hydrophilic amino acid with an affinity for aqueous systems. Because of this it is relatively highly reactive, and is therefore an important component of a large number of enzymes and proteins.

Although, after all, it is not an essential amino acid, deficiencies can occur in the young and in the old, and also in those suffering certain metabolic diseases. Dietary sources include high-protein foods such as chicken, turkey, pork, dairy products and vegetables such as cereals, broccoli, garlic and onions.

The biochemistry of this amino acid begins with another amino acid known as serine, and also methionine. The latter is fist converted to homocysteine, which is then combined with serine to form cystathionine. This is then converted into cysteine and alpha- ketobutyrate. The thiol group is highly reactive and gives cysteine its biological properties.

L-Cysteine possesses strong antioxidant properties due to the thiol group which easily undergoes redox reactions. However, it is for its detoxification effect on the body that the amino acid is mainly taken as a supplement. It is, therefore, these properties that we shall discuss first.

Cysteine can reduce the toxic effects of alcohol, such as a hangover or the more serious liver damage. The by-product of alcohol metabolism that does most damage and is responsible for the majority of the negative after-effects of excessive alcohol consumption is acetaldehyde. L-Cysteine converts acetaldehyde into the more acceptable acetic acid, and so prevents the aldehyde from having too much of a negative effect on your health and well-being. However, the results obtained from such studies have been from animals only, and the therapeutic effects of cysteine have not yet been tested on humans.

What has been tested and is known is that L-cysteine is effective in the detoxification of heavy metals in the body. A common source of heavy metal toxicity is mercury from amalgam fillings in the teeth. Although the Environmental Protection Agency (EPA) declared in 1989 that dental amalgams are a hazardous substance under the Superfund law, many people still have them in their mouths.

The thiol group and L-cysteine has a high affinity for mercury and other heavy metals, as previously stated, and a supplement can be used to remove from the body any mercury leached from mercury-based tooth fillings. It can also be used to bind to copper, lead and cadmium. Lead and cadmium are particularly toxic to the human body, and even though lead is no longer used in plumbing or paints, and cadmium in toys or paints, there are still many sources of these two heavy metals available that can lead to human toxification.

An L-cysteine supplement can be used to remove these heavy metals from the body. Any proteins containing cysteine will tightly bind heavy metals such as lead, cadmium, molybdenum, cobalt and mercury, and allow them to be excreted by the body in the usual fashion. This direct involvement in heavy metal detoxification is a very useful property of this amino acid.

Another detoxification application of L-cysteine is in direct involvement in protecting cellular glutathione levels, and also the prevention of the death of liver cells by acetaminophen poisoning. The latter is of particular interest to many people since acetaminophen is better known as paracetamol, and since this is a freely available over-the-counter drug, overdoses are not unknown. The result of an overdose is the necrosis of liver cells, with eventual liver failure and death.

The treatment of choice is N-acetylcysteine. If used within 10 hours of the overdose it is extremely effective, and even from 16 to 24 hours it is better than other controls. It is believed that the acetylcysteine liberates cysteine which, when available to the liver, enables the biosynthesis of glutathione. Glutathione can then maintain the production of the fifth metabolite required for the specific detoxification of the paracetamol/acetaminophen.

L-Cysteine is also an essential component in the biosynthesis of coenzyme A, an enzyme essential for the production of energy from fats and carbohydrates. It is also a very important component of hair, from which it is commercially produced. Without an adequate intake of L-cysteine the growth of healthy hair would not be possible.

There are several supplemental uses of L-cysteine including the treatment of bronchial conditions for which the amino acid can help to liquefy and clear mucus from the airways and lungs. It is also used to protect against side effects of chemotherapy treatment of cancers and for medical treatments for excessive exposure to radiation.

However, there are certain situations in which L-cysteine should be avoided when at all possible. Diabetics should not use it, and neither should those suffering from cystinuria, whereby large quantities of amino acids, including cystine, are excreted in their urine. L-cystine, incidentally, is formed by oxidation of L-cysteine.

Paradoxically the amino acid is one of the several hundred additives made to tobacco by the cigarette companies. Although, as with the majority of tobacco additives, its purpose is unknown there are two possible reasons for its inclusion. L-Cysteine is a known expectorant, so it could be added to promote the expectoration of mucus in the lungs which is promoted by smoking, and it also increases the production off the antioxidant glutathione that is depleted in smokers.

There are several other non-medical uses for the amino acid, but it is for is its detoxification properties that it is most used as a supplement. However, because it is largely derived from human hair or Duck feathers, it may not be classed as kosher or halal in spite of many claims made to that effect, though the more expensive source of microbial fermentation from corn sugar can be.

The substance is recognized as safe by the FDA, and must be labeled as L-cysteine when it is present in a preparation intended for its therapeutic effects. Keep in mind however, that it should be avoided by diabetics.

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Bird Flu Vaccine in short supply !!
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Date: November 26, 2005 02:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bird Flu Vaccine in short supply !!

U.S Unprepared for Bird Flu Pandemic

Vaccine in short supply.

Officials worldwide are preparing for the worst, as bird flu spreads through asia and into Europe, resulting in the death of 140million chickens and Ducks. Meanwhile waterfowl travel their migratory paths, shedding virus contaminated feathers, droppings and saliva into the water, air and soil.

Human cases of avian flue have so far been limited to individuals who had direct contact with sick birds. Experts, however, believe the virus could mutate into a form easily transmitted from human to human. The current strain, known as H5N1, is particularly lethal; it has killed 61 people—half of those infected.

A few times each century, flu pandemics sweep the world. One of the worst, the 1918 flu, killed 50 million people; it was also a bird flu, which jumped directly to humans. The grimmest forecast today is a pandemic that could kill millions. And, among developed nations, the united states is one of the least prepared.

After Delay, U.S. Must Wait in Line.

Congress and the President are considering spending billions to buy the drub tamiflu, which has been shown to reduce the duration and severity of bird flu. A few months ago, the manufacturer could have delivered much of this supply; now, orders placed by other countries have exhausted production capacity for the next two years, according to the New York Times. U.S. health agencies have 2 million doses on hand, enough to treat 1% of the population.

A Military Response?

Anticipating a crisis, President Bush asked Congress to consider using the military to enforce a quarantine, and requested a review of the Posse Comitatus Act of 1878, which prohibits the armed forces from engaging in domestic policing. Critics question the effectiveness of a military response to a health problem, and point out that authorities can already call in the National Guard to deal with civil disorders.

Contagious Disease and the Wellness Revolution.

Concentrations of poverty, especially in Asia; huge, crowded farms and factories; poor hygiene; insufficient public health facilities; companies that refuse to produce unprofitable vaccines—all must be addressed to prevent future pandemics.

Meanwhile, individuals must do all they can to protect themselves. Wash your hands often and keep them away from your eyes and nose. Avoid contact with people who have respiratory illnesses. Clean surfaces used to prepare raw poultry with hot, soapy water, and cook poultry thoroughly. With so many potential assaults on your health, a wise strategy that is at the very core of the wellness revolution is to strengthen your immune system. Get enough sleep, take good daily multiple, and visit your health food store for a wide range of immune-boosting herbs and special nutrients to help you stay well this winter.

Sources: After Delay, U.S. Faces Line of Flu Drug, New York Times, 10/7/05; U.S. Warns of Future Flu Pandemic, Associated press, 10/10/05; Review of the monster at our door: the global threat of avian flue by Mike Davis.

Bird Flu Facts:

Symptoms: fever, cough, sore throat, aches, pneumonia.

Virulence of current strain: kills 100% of birds, 50% of humans.

Projected U.S. Pandemic Death toll: ½ million.



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Red Yeast Rice For Lipid Wellness
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Date: June 04, 2005 02:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Red Yeast Rice For Lipid Wellness

Red Yeast Rice

Maintaining cardiovascular health is a fundamental strategy in the holistic healing system. It may be the most important thing you can do for your body. One of the factors for optimal cardiovascular health is keeping your lipid levels within the normal range. But with today’s fast-paced lifestyle, it’s hard to maintain a healthy diet and exercise program. Red yeast rice is a natural product that supports maintenance of normal lipid levels. Source Naturals RED YEAST RICE is standardized to 1.5% mixed mevinolinic acid monacolins. These monacolins block the synthesis of lipids in the liver by binding to the lipids production enzyme HMG-CoA reductase. Support your lipid wellness with the quality and science of Source Naturals RED YEAST RICE.

The Liver and Lipid

The amount of lipid you consume in food is not the most important factor for regulating normal lipid levels. The liver manufactures approximately 80% of total body lipid while the other 20% comes from dietary sources. Our bodies require lipid but we can also get too much of it. Lipid is only harmful to us if it becomes oxidized. Oxidized lipid can cause damage to tissues and accumulate in blood vessels. Balancing the lipid produced by your liver is critical to your total lipid and your cardiovascular health.

Red Yeast Rice

Red yeast rice has been used in China for centuries to make rice wine, to color and flavor foods such as Peking Duck and as a health promoting food. It is prepared by fermenting a type of yeast (Monascus purpureus) over rice. Red yeast rice is a complex product that contains several active ingredients including monacolins. Monacolins act as HMG-CoA inhibitors. HMG-CoA reductase is an enzyme that helps make lipid. By blocking its lipid producing action, the natural compounds in red yeast rice can help you maintain lipid levels that are within the normal range. A double blind clinical trial using red yeast rice and placebo with 80 human subjects was conducted at UCLA. After eight weeks with no changes in diet composition the group taking red yeast rice maintained healthy lipid levels.

Natural Support For Your Heart

Nature provides us with special compounds that allow us to explore safe alternatives to support our health. Taking personal responsibility for your health is at the heart of the wellness revolution. Changing your lifestyle is one of the most effective ways to take that responsibility and provide support and protection for your heart. A diet low in lipid, saturated fats and trans-fatty acids, and high in complex carbohydrates and fiber is important. Exercise regularly, quit smoking and supplement your diet with heart-healthy compounds such as red yeast rice, CoQ10, folic acid, garlic, omega-3 fatty acids, carnitine, hawthorn berry extract, arginine, vitamin E and tocotrienols. Source Naturals RED YEAST RICE is standardized to 1.5% mixed mevinolinic acid monacolins. This standardization process provides you with the assurance that you are getting a consistent concentration of these compounds in each dose. RED YEAST RICE is part of Source Natural’s extensive line of products scientifically formulated to provide support for your cardiovascular health.

References:
Heber, David. Lipid-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. American Journal of Clinical Nutrition 1999: 69(2):231-236. Zhu Y, Li CL, Wang YY, Zhu JS, Chang J, Kritchevsky D. Monascus purpureus (red yeast): a natural product that lowers blood lipid in animal models of hyperlipidemia. Nutr Res 1998; 18:71-81. Medical Encyclopedia. Medlineplus Health Information [online]. U.S. National Library of Medicine and the National Institutes of Health, 2003 [October 22, 2003]. Available from World Wide Web: edlineplus/ encyclopedia.html.



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