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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs Frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity Frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - Frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Does Methylation Effect Active Vitamin D3 Levels in the body?
Date:
July 08, 2026 12:43 PM
Yes, methylation directly and significantly impacts how efficiently your body converts Vitamin D3 into its active, usable form. This relationship operates on two distinct levels: epigenetic DNA methylation (which acts as a volume knob for the conversion enzymes) and the cellular methylation cycle (which shares a profound reciprocal feedback loop with active Vitamin D). To see exactly where methylation interferes, it helps to look at the standard two-step activation pathway:
1. DNA Methylation (The Epigenetic "Dimmer Switch")DNA methylation is an epigenetic mechanism where methyl groups are attached to a gene's promoter region, typically silencing or "turning down" its expression.
2. The Systemic Methylation Cycle Feedback LoopWhile S-adenosylmethionine (SAMe) is not a direct chemical cofactor required for the hydroxylation reactions themselves (which rely on NADPH and the cytochrome P450 enzyme network), the systemic methylation cycle and Vitamin D share a massive reciprocal cross-talk mechanism.
The Vitamin D "Non-Responder": Is Your DNA Dimming Your Supplement’s Power? Yes, higher active Vitamin D3 levels consistently cause homocysteine levels to drop. Large-scale observational studies and gold-standard randomized controlled trials (RCTs) confirm a distinct, inverse relationship: as your Vitamin D status optimizes, circulating total homocysteine decreases. When active D3 binds to the Vitamin D Receptor (VDR), it triggers specific genetic and cellular actions that clear homocysteine through multiple pathways. The Biological MechanismsActive Vitamin D doesn’t just lower homocysteine through one pathway; it exerts a multi-pronged push to keep the toxic amino acid from accumulating.1. Upregulation of Methionine Synthase (MTR)While active D3 supports the alternative BHMT (betaine) pathway, recent molecular research highlights an even more direct impact on the primary, folate-dependent remethylation loop.
2. Safeguarding Enzyme Function via Oxidative Stress ReductionThe primary enzyme responsible for clearing homocysteine, Methionine Synthase, is incredibly sensitive to oxidative stress. Under high inflammation or oxidative conditions, the cobalt atom at the heart of its B12 cofactor becomes oxidized, completely disabling the enzyme and causing a major homocysteine backup.
3. Preserving Liver and Kidney FunctionThe alternative remethylation pathway, BHMT, operates almost exclusively in the liver and kidneys. If these organs experience structural or metabolic strain, their capacity to process homocysteine drops drastically. Active Vitamin D protects hepatic and renal tissue architecture, ensuring the local cellular machinery required for the betaine-homocysteine conversion remains functional.What the Clinical Trials ShowIn human trials, the drop isn't just theoretical - it's highly measurable.The Clinical Evidence: In double-blind, randomized, placebo-controlled trials, individuals with low baseline Vitamin D and elevated homocysteine were given high-dose Vitamin D3 (e.g., 50,000 IU weekly) over a two-month period. The treatment groups consistently showed statistically significant drops in total serum homocysteine, alongside reductions in body mass index (BMI) and systemic inflammatory markers, while the placebo groups saw no change. If someone is dealing with stubborn hyperhomocysteinemia (elevated homocysteine) and pushing hard on methylated B-vitamins (like methylfolate and TMG/betaine) without seeing their numbers budge, a hidden Vitamin D deficiency or a high-methylation genetic barrier at the CYP2R1 liver enzyme is very Frequently the missing link. Summary: The relationship between Vitamin D3 activation and the body's biochemical pathways operates as a highly coordinated, reciprocal feedback loop. On an epigenetic level, DNA methylation acts like a cellular dimmer switch for the liver enzyme CYP2R1, which is responsible for converting raw D3 into its circulating form. When the promoter region of this gene is heavily methylated, enzyme production is suppressed, explaining why some individuals act as clinical "non-responders" who struggle to raise their blood levels even with high-dose supplementation. Once Vitamin D is successfully activated, however, it turns around and directly reinforces the systemic methylation cycle by binding to the Vitamin D Receptor (VDR) and upregulating the BHMT gene, which is vital for maintaining the body's universal methyl donor (SAMe) pool. Conversely, maintaining robust levels of active Vitamin D3 plays a direct, clinically proven role in forcing circulating homocysteine levels to drop. When active D3 binds to its receptor, it triggers a multi-pronged clearance strategy by activating the Nrf2 cellular defense pathway, which upregulates Methionine Synthase (MTR) - the primary enzyme that converts toxic homocysteine back into harmless methionine. Furthermore, by acting as a powerful systemic anti-inflammatory, active Vitamin D lowers the oxidative stress that would otherwise oxidize and disable the delicate B12 cofactors inside these clearance enzymes. This dual action of increasing enzyme production while shielding existing enzymes from environmental damage explains why clinical trials consistently show significant reductions in serum homocysteine when Vitamin D status is optimized.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6644) Is there anything else DLPA can do be sides Pain management and Mood?
Date:
May 22, 2026 04:29 PM
Here is what else DLPA can do:
When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.
Here are a few of the more complex, nuanced roles of DLPA in the body:
By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.
Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.
The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.
Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?
Summary:
Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.
In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6640)
Date:
May 22, 2026 12:27 PM
To understand how it works, it helps to break down the molecule. DLPA is a 50/50 mixture of two stereoisomers (mirror-image structures) of the essential amino acid phenylalanine:
Chronic pain rarely exists in a vacuum—it is deeply linked to systemic fatigue, mood degradation, and depression. Because chronic pain is neurologically exhausting, it Frequently depletes the brain's stimulating neurotransmitters.
The L-phenylalanine half of DLPA acts as the raw precursor material for the catecholamine pathway. Your body converts it into tyrosine, which is then synthesized into dopamine, norepinephrine, and epinephrine (adrenaline). By combining both forms, DLPA provides a dual-action effect: the D-form raises the pain threshold, while the L-form combats the mental fatigue and mood dips that inevitably accompany long-term discomfort.
Key insight: Because DLPA relies on shifting enzyme levels and allowing endorphins to accumulate, it is primarily effective for chronic pain (like osteoarthritis or lingering injuries) rather than acute, immediate pain. It often requires several days to weeks of consistent use to reach its full therapeutic effect.
Summary:
DLPA (DL-phenylalanine) is a nutritional supplement combining two mirror-image forms of an essential amino acid to provide a unique approach to chronic pain management. Unlike standard pain relievers that suppress inflammation, the "D" form of the molecule acts as a biochemical shield for the body's built-in painkilling system. It functions as an enkephalinase inhibitor, meaning it blocks the specific enzymes responsible for destroying circulating endorphins and enkephalins. By protecting these natural opioids from premature breakdown, DLPA allows them to accumulate and remain active longer, effectively raising the body's natural pain threshold.
Because chronic pain is neurologically exhausting and Frequently leads to fatigue or lowered mood, the "L" half of the supplement provides critical mental support. L-phenylalanine serves as a raw precursor for synthesizing stimulating neurotransmitters, including dopamine, norepinephrine, and epinephrine (adrenaline). Together, this dual-action mechanism addresses both the physical sensation of lingering discomfort and the mental fatigue that accompanies it, making DLPA uniquely suited for sustained, long-term pain conditions rather than immediate, acute injuries.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6639)
Date:
May 31, 2024 11:05 AM
Stevia, a natural sweetener that has become globally popular in recent years, boasts a rich history spanning centuries. This article delves into the origins and historical significance of stevia, shedding light on its traditional use by indigenous peoples and its evolution into a mainstream alternative to sugar.
Stevia, scientifically known as Stevia rebaudiana, originates from South America. This small, green plant is part of the Asteraceae family, which also includes daisies and sunflowers. The leaves of the stevia plant contain sweet compounds known as steviol glycosides, which are responsible for its sweetness.
The historical journey of stevia begins with the Guaraní people of Paraguay and Brazil, who have used the plant for over 1,500 years. The Guaraní referred to stevia as "ka'a he'ê," which translates to "sweet herb." They traditionally used stevia leaves to sweeten beverages like yerba maté, a popular herbal tea, and to enhance the flavor of various traditional dishes. Stevia wasn't just a sweetener for the Guaraní; it also held medicinal importance. The leaves were used to treat a variety of conditions, including burns, stomach issues, and as a general tonic. This dual use of stevia as both a sweetener and a medicinal plant highlights its invaluable role in indigenous culture.
The modern history of stevia began in the 16th century when European explorers first arrived in South America. Spanish botanist and physician Pedro Jaime Esteve (1500–1556) is often credited with the early European studies on stevia, although the plant was not widely documented until later. Interest in stevia grew in the early 20th century when it was scientifically studied by Paraguayan chemist Ovidio Rebaudi. Rebaudi analyzed the sweet properties of stevia leaves and confirmed that they were much sweeter than sugar, which caught the attention of the scientific community.
In the 1970s, stevia began gaining traction in Japan as the country sought alternatives to artificial sweeteners. Japanese researchers developed methods for extracting and refining steviol glycosides from stevia leaves, making it possible to use stevia as a commercial sweetener. The success of stevia in Japan set the stage for its global acceptance.
Stevia's rise in popularity can be attributed to its myriad of health benefits. Unlike sugar, stevia is calorie-free, making it an attractive option for those managing their weight. Additionally, stevia has a negligible effect on blood glucose levels, which is beneficial for individuals with diabetes or those monitoring their carbohydrate intake. Moreover, steviol glycosides are stable at high temperatures, making stevia a versatile sweetener suitable for cooking and baking. This thermal stability, combined with its natural origin, has positioned stevia as a preferred option for health-conscious consumers.
The journey of stevia to becoming a global sweetener has involved rigorous scientific scrutiny and regulatory approval. In 2008, the United States Food and Drug Administration (FDA) granted stevia the status of "Generally Recognized As Safe" (GRAS), which paved the way for its use in a wide range of food and beverage products. Following the FDA's approval, other countries, including those in the European Union, Canada, and Australia, also approved the use of stevia in food and beverages. Today, stevia is found in everything from soft drinks to baked goods, reflecting its widespread acceptance and global reach.
Despite its many advantages, the path to widespread adoption of stevia has not been without challenges. One of the initial hurdles was the aftertaste associated with some of the early stevia extracts. However, advances in extraction and formulation techniques have significantly improved the taste profile of stevia, making it more palatable for consumers. Another challenge has been ensuring the sustainable cultivation of stevia. As demand grows, it is essential to implement agricultural practices that support environmental sustainability and fair labor conditions for farmers.
The future of stevia holds exciting possibilities as ongoing research continues to explore new applications and improvements. Scientists are currently investigating the potential of stevia extracts in providing health benefits beyond sweetness, such as their antioxidant properties and possible roles in managing certain health conditions. Innovations in biotechnology are also paving the way for the development of new stevia varieties with enhanced sweetness and improved agronomic traits. These advancements could further solidify stevia's position as a key player in the global sweetener market.
The history of stevia is a fascinating journey from the rainforests of South America to the shelves of supermarkets around the world. From its traditional use by the Guaraní people to its rediscovery by European explorers and subsequent global adoption, stevia has proven to be a remarkable sweetener with enduring significance. As the modern world continues to prioritize health and wellness, stevia's natural sweetness offers a much-needed alternative to sugar, promising a future where we can enjoy the sweetness of life without compromising our health.
If you've been searching for a healthier way to satisfy your sweet tooth, the journey of stevia offers a compelling reason to make the switch. With its rich history rooted in traditional use by the Guaraní people, and its scientifically-backed benefits recognized globally, stevia stands out as a truly remarkable sweetener. Free from calories and gentle on blood glucose levels, it's an excellent choice for both weight management and diabetes care. Plus, its versatility in cooking and baking means you won't have to compromise on your favorite recipes. Join the growing number of health-conscious consumers who are choosing stevia for a naturally sweet life. Explore its various forms—from whole leaves to refined steviol glycosides—and incorporate this natural sweetener into your diet today. Embrace the future of sweetening and enjoy the benefits of stevia for yourself and your loved ones.
Stevia is a natural sweetener derived from the leaves of the Stevia rebaudiana plant, which is native to South America. It has been used for centuries by the Guaraní people and is known for being much sweeter than sugar while containing zero calories.
Stevia can be used in various forms, including whole leaves, powdered extracts, and liquid concentrates. It is commonly used to sweeten beverages, baked goods, and other foods. Thanks to its stability at high temperatures, stevia can also be used in cooking and baking.
Yes, stevia is considered safe for consumption. The United States Food and Drug Administration (FDA) has granted stevia the status of "Generally Recognized As Safe" (GRAS). It has also been approved for use in many other countries, including those in the European Union, Canada, and Australia.
Stevia can be an effective tool for weight management because it contains no calories. Replacing sugar with stevia in your diet can help reduce overall calorie intake, which may contribute to weight loss or maintenance.
Stevia is suitable for people with diabetes as it has a negligible effect on blood glucose levels. This makes it a preferable alternative to sugar for those needing to monitor their carbohydrate intake. However, it is always best to consult with a healthcare provider before making any significant changes to your diet.
Stevia is generally well-tolerated and considered safe for most people. However, some individuals may experience mild side effects, such as digestive discomfort, when consuming large amounts. It is advisable to use stevia in moderation.
Stevia is known to be much sweeter than sugar, and its taste can vary depending on the form used and the specific product. Early versions of stevia extracts were noted for having a slight aftertaste, though modern formulations have significantly improved the taste profile.
Stevia is typically grown in subtropical and tropical climates. Sustainable cultivation practices are essential as the demand for stevia increases. These practices include using environmentally friendly agricultural methods and ensuring fair labor conditions for farmers.
Stevia has the potential to be more sustainable than traditional sugar crops. It requires less land and water to produce the same level of sweetness, which can reduce the environmental impact associated with sugar cultivation.
Yes, stevia can be used in baking due to its high-temperature stability. However, because it is much sweeter than sugar, recipes may need to be adjusted to account for its intensity. Many commercially available stevia sweeteners come with specific usage guidelines for cooking and baking.
Yes, stevia products come in various forms, including whole leaves, powdered extracts, and liquid concentrates. Some products are blended with other sweeteners or filler ingredients to better mimic the taste and texture of sugar.
Stevia is a natural sweetener, which sets it apart from many artificial sweeteners. It is derived from a plant and does not undergo extensive chemical processing. Many consumers prefer stevia because it is perceived as a more natural and healthier option.
Ongoing research on stevia explores its potential health benefits beyond sweetness, such as its antioxidant properties and possible roles in managing certain health conditions. Innovations in biotechnology are also working to develop new stevia varieties with enhanced sweetness and other desirable traits.
Stevia products are widely available at VitaNet LLC. Stevia can be found in the baking aisle or the section dedicated to natural and alternative sweeteners. By understanding the benefits and uses of stevia, you can make an informed decision about incorporating this natural sweetener into your diet. With its rich history, proven health benefits, and versatility, stevia offers a compelling alternative to traditional sugar.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6607)
Date:
December 07, 2023 12:12 PM
Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of Frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
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Date:
November 04, 2023 10:53 AM
Magnesium is an essential mineral for the body, playing a crucial role in the regulation of blood pressure and numerous other bodily functions. The shortcoming of this nutrient can be addressed through the consumption of magnesium glycinate, a supplement also known as magnesium diglycinate and magnesium bisglycinate. Key Roles of Magnesium This article delves into the details of magnesium glycinate, looking at its benefits, potential side effects, the recommended dosage, and more. The human body needs a significant amount of magnesium for optimal function. Although the best way to obtain nutrients is in their natural form, supplements like magnesium glycinate are available to enhance magnesium intake in individuals with low levels. Benefits of this supplement include: Precautionary Measures Sources of Magnesium Glycinate Nutritional sources rich in magnesium include legumes, nuts, seeds, whole grains, spinach, fortified breakfast cereals, yogurt, milk, and other dairy products. Recommended Dosage The amount of magnesium glycinate to be taken can vary. It is advised to consult a doctor before starting a magnesium glycinate regimen. Potential Side Effects Magnesium glycinate, like other dietary supplements, can cause side effects such as nausea, abdominal cramps, and diarrhea when taken in large or Frequent doses. However, a study from 2013 indicated that magnesium glycinate is less likely to induce diarrhea compared to other magnesium supplements. Extreme doses could lead to magnesium toxicity, resulting in more severe side effects. Easy Ways to Consume More Magnesium One effective method of increasing magnesium intake is by incorporating dietary supplements into your daily regime. For instance, Solaray Magnesium Glycinate is a popular supplement that is widely recognized for its efficacy. It is an easily digestible form of magnesium that is gentle on the stomach and less likely to induce diarrhea. Solaray's supplement provides an accessible option for those looking to supplement their diet with magnesium, especially for individuals who might struggle to meet their nutritional requirements through diet alone. Conclusion Magnesium glycinate can be a beneficial supplement for individuals with magnesium deficiency. However, caution must be exercised in its consumption, with potential side effects and individual health conditions taken into account. As always, it is best to seek medical advice before starting a new supplement regimen.
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Date:
October 25, 2022 02:32 PM
Guar gum is a food additive that is derived from the guar bean. It is commonly used as a thickening agent, and can be found in a variety of products, such as frostings, ice cream, and sauces. Guar gum is also Frequently used when baking with whole grain flours, as it helps to improve the texture and consistency of the finished product.
Guar Gum vs. Xanthan Gum
Guar gum and xanthan gum are both food additives that are derived from plant sources. They are both commonly used as thickeners, and can be found in a variety of foods, such as salad dressings, ice cream, and jams. Guar gum is made from the guar bean, while xanthan gum is made from fermented corn sugar. Both guar gum and xanthan gum are vegan-friendly and gluten-free.
Xanthan gum is a more versatile thickener than guar gum, as it can be used in both hot and cold dishes. Additionally, xanthan gum has a longer shelf life than guar gum. Xanthan gum is also more effective than guar gum at creating viscosity, or thickness, in liquids. However, guar gum is less expensive than xanthan gum, which makes it a more popular choice for many home cooks and bakers.
If you are looking for a thickening agent for your baking recipes that call for whole grain flour, then guar gum is a good option to consider. Guar gum will help to improve the texture of your baked goods, and can also be used in other dishes such as sauces and frostings. Keep in mind that xanthan gum is a more versatile thickener than guar gum, but it is also more expensive. Ultimately, the decision of which thickener to use will come down to personal preference and budget.
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Date:
April 29, 2022 03:10 PM
The kidneys are two bean-shaped organs that sit in the lower back, on either side of the spine. They play a vital role in your health, filtering toxins from the blood and regulating fluid balance in the body. We will discuss everything you need to know about the kidneys, including common kidney problems and how to keep them healthy!
What are the common kidney problems
The kidneys are a pair of organs that filter waste products from the blood and excrete them in urine. They are also responsible for regulating fluid and electrolyte balance in the body. Kidney problems can range from mild to severe, and can be acute or chronic. Common kidney problems include kidney stones, urinary tract infections, and Nephrotic Syndrome. Kidney stones are small, hard deposits that form in the kidney when there is an imbalance of minerals in the urine. Urinary tract infections occur when bacteria enter the urinary system and multiply. Nephrotic Syndrome is a kidney disorder that causes the body to excrete large amounts of protein in the urine.Kidney problems can often be treated with medication, but in some cases, surgery may be necessary. Early diagnosis and treatment is important to prevent serious complications.
Acute renal failure
Acute renal failure is a sudden onset of kidney failure that can be life-threatening. The kidneys are responsible for filtering waste from the blood and balancing fluids in the body. When they are not working properly, waste can build up in the blood and cause serious health problems. Acute renal failure can be caused by a number of factors, including dehydration, infection, and certain medications. Symptoms include decreased urine output, swelling, fatigue, and confusion. If left untreated, acute renal failure can lead to coma and death. Early diagnosis and treatment is essential for a successful outcome.
Chronic renal failure
Chronic renal failure, or CRF, is a serious medical condition that affects the kidneys. In this condition, the kidneys become damaged and unable to function properly. As a result, toxins can build up in the body, causing a variety of symptoms. Some of these symptoms may include fatigue, bloating and swelling, nausea, diarrhea or constipation, poor appetite, changes in urination Frequency or color, and anemia. Diagnosing CRF involves examining several factors like blood test results and overall medical history. Treatment for the condition typically involves managing any associated symptoms with medication or dietary changes. In some cases, dialysis may also be necessary to support patients with severe CRF. Overall, chronic renal failure is a serious but manageable condition that requires careful monitoring and management by patients and their healthcare providers.
Renal artery stenosis
Renal artery stenosis refers to a condition in which one or more of the arteries that deliver blood to the kidneys becomes narrowed or blocked. This can lead to a number of adverse health effects, including increased blood pressure, chronic kidney failure, and possibly even heart attack or stroke. While there are a number of possible causes for this condition, including genetic factors, certain lifestyle choices such as smoking can also increase the risk of developing renal artery stenosis. Fortunately, treatments are available for this condition, including medications and medical procedures like angioplasty. For those who are diagnosed with renal artery stenosis, early and effective treatment is essential for maintaining overall health and wellbeing.
Renal cancer
Renal cancer begins in the kidneys, which are a pair of bean-shaped organs that filter waste from the blood and produce urine. The most common type of renal cancer is clear cell renal cell carcinoma (RCC), which accounts for about three-quarters of all cases. RCC typically affects middle-aged adults and is more common in men than women. Other types of renal cancer include papillary renal cell carcinoma, chromophobe renal cell carcinoma, and collecting duct carcinoma. Treatment for renal cancer may include surgery, radiation therapy, chemotherapy, targeted therapy, or immunotherapy. The type of treatment will depend on the stage of the cancer and the patient's overall health. Early diagnosis and treatment is essential for the best possible outcome.
Polycystic kidney disease
Polycystic kidney disease, or PKD, is a complex condition that affects the kidneys and other organs in the body. This disorder occurs when small cysts grow in the kidneys, gradually interfering with their ability to filter waste products from the blood. As these cysts start to expand, they can cause a number of severe symptoms such as high blood pressure, chronic pain, nausea and fatigue. In some cases, PKD also results in serious complications such as renal failure or a stroke. However, there are treatments available that can help people manage this disorder and slow its progression over time. By working closely with a medical team and making lifestyle changes to support kidney health, it is possible for people living with PKD to have long and healthy lives.
Urinary tract infection
A urinary tract infection (UTI) is an infection that can occur in any part of the urinary system, including the kidneys, ureters, bladder, or urethra. UTIs are most commonly caused by bacteria, but they can also be caused by fungi or viruses. Symptoms of a UTI may include pain or burning during urination, increased Frequency or urgency of urination, cloudy or blood-tinged urine, and pelvic pain. If left untreated, a UTI can lead to serious complications, such as kidney damage or sepsis. Early diagnosis and treatment is essential for preventing serious health problems. UTIs are typically diagnosed through urinalysis, which can detect the presence of bacteria or other organisms in the urine. Treatment usually involves antibiotics to kill the infection-causing bacteria. In some cases, hospitalization may be necessary to treat a severe UTI. Additionally, drinking plenty of fluids and emptying the bladder Frequently can help to flush out bacteria and prevent reinfection. Wiping from front to back after using the restroom can also help to reduce the risk of UTI development. Avoiding masturbation devices would good idea if you get Frequent urinary tract infections because they can introduce new bacteria into the urethra.
UTI and D-Mannose
A urinary tract infection, or UTI, is a common medical condition that can cause symptoms such as painful urination, abdominal discomfort, and sometimes even fever. While conventional treatments typically involve antibiotics, these medications often come with unwanted side effects like nausea and diarrhea. Fortunately, there is another alternative in the form of D-Mannose, a naturally-occurring sugar that has been shown to help treat UTIs by eliminating bacterial biofilms and relieving symptoms. Unlike antibiotics, which can damage gut health by killing off beneficial bacteria along with the harmful ones, D-Mannose does not disrupt this critical ecosystem. As a result, D-Mannose is becoming an increasingly popular treatment for UTIs, offering an effective and safe alternative to antibiotics.
Kidney stones
Kidney stones are one of the most painful medical conditions to experience. These small, hard deposits form when there is an imbalance in the levels of certain minerals in the body. As they grow larger, kidney stones can cause severe pain as they move through the urinary tract. Treatment typically involves drinking plenty of fluids and taking pain medication. In some cases, surgery may be necessary to remove the kidney stone. Prevention is the best way to avoid kidney stones, and maintaining a healthy diet and lifestyle is the best way to do this. Drinking plenty of fluids, especially water, and eating a diet high in fiber can help to prevent kidney stones from forming.
Glomerulonephritis
Glomerulonephritis is a serious kidney condition that occurs when the tiny filtration units in the kidneys, known as glomeruli, become inflamed and damaged. This can disrupt normal kidney function, causing a buildup of waste products in the bloodstream, resulting in numerous symptoms such as swelling and joint pain. While there is no cure for glomerulonephritis, treatment options can help to reduce inflammation and manage symptoms. These may include medications to control blood pressure or reduce harmful inflammatory chemicals, along with lifestyle changes to support overall kidney health. With proper medical care and close monitoring, many people with glomerulonephritis are able to live healthy lives despite this chronic condition.
Kidney disease is a serious condition that can lead to a variety of health problems. If you have kidney disease, it is important to monitor your symptoms and seek medical treatment as soon as possible. There is no one-size-fits-all approach to managing kidney disease, but by working with your healthcare team and following their recommendations, you can help improve your health and quality of life. Remember, knowledge is power, so be sure to educate yourself about kidney disease and its treatment options. With the right information and support, you can live a full and productive life despite this serious condition.
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Date:
May 09, 2019 05:01 PM
If you are losing hair faster than normal, you could be biotin deficient. Biotin is also known as Vitamin B7 and supports the health and growth of hair and nails. Nuts, sweet potatoes and dark leafy vegetables are all rich in Biotin. Onions also have biotin. The best source of biotin is actually animal liver. If you cannot eat liver, consider eggs instead. Three eggs a day will provide your daily requirement of Biotin without the taste of liver. Key Takeaways: "Also known as vitamin B7, biotin supports the healthy growth of hair, skin, and nails." Read more: https://www.naturalnews.com/2019-04-03-shiny-hair-stronger-nails-add-these-8-biotin-rich-foods.html
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Date:
May 09, 2019 04:37 PM
People who frequently experience bouts of anxiety and frequent periods of stress may find it hard to wind down after a hard day at work. This can then result in the inability to relax and inability to sleep. That is why anxiety and stress are recognized as the two most prominent leading causes of insomnia. Insomnia on the other hand takes a major toll on one’s physical health and mental well-being. What could be the solution? Researchers have found that this could be keeping a jasmine plant in the house. The scent which the jasmine plant releases has been linked to a reduction in anxiety and stress. The author states that the Jasmine plant is a flower that blooms at night with a sweet fragrance and exciting smell. Companies use it to make teas, incense, essential oils, and then perfumes. Its health benefits are immense and it has been used to treat diabetes, hepatitis, and cancer. It can now be proved that it can used to reduce anxiety and stress in individuals. It is estimated that about 40 million adults are affected yearly by anxiety and stress. The author then states the pathways in which jasmine works. Key Takeaways: "One way to combat a high level of toxins in the air is to keep a jasmine plant nearby. Research concludes a jasmine plant in your room can serve as relief for sleeplessness, anxiety, and stress, among other illnesses. Simply breathing the aromatic scent of the plant can help to significantly calm your anxieties." Read more: https://www.healthnutnews.com/keep-a-jasmine-flower-in-your-room-to-reduce-stress-and-anxiety-study-finds-its-as-calming-as-valium/
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Date:
April 04, 2019 12:52 PM
If you find your self feeling a little more susceptible to all of those nasty bugs going around this season, this article has a few tips for you to keep in mind. By consuming foods and supplements containing vitamin C such as lemons, amla and cherries, you help provide your body with a small boost to your immunity system that may determine the course of your day. Take a few moments out of your day to get a bit more knowledge on Vitamin C. Key Takeaways: "This vibrant red-coloured fruit is not only a treat to the palate, but also a storehouse of essential nutrients, including vitamin C. In order to get your daily dose of vitamin C, you can have cherries as is or make them a part of your diet by adding them in smoothies, shakes or even desserts." Read more: https://www.ndtv.com/food/eat-these-vitamin-c-rich-foods-to-boost-your-immunity-1992440
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Date:
February 18, 2019 01:38 PM
If you aren't aware of the healing powers of lavender essential oil, prepare for some exciting surprises. Many people know how amazing the lavender essential oil smells and that it promote relaxation. But , they don't know its many other great uses. Did you know that the oil can help treat ulcers and yeast infections or that it can help improve your sleep? These are a few of the many benefits that you get when using lavender essential oil! Key Takeaways: "Its medicinal use can be traced back to more than 2,500 years ago where it was widely used in traditional Chinese medicine." Read more: https://www.naturalnews.com/2019-02-13-7-proven-uses-of-lavender-essential-oil.html
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Date:
December 17, 2018 12:59 PM
Eleuthero is another name for Siberian Ginseng, an herbal remedy which has been used for at least 2000 years. It is distantly related to another, better-known herbal remedy, Asian ginseng. It is also sometimes called Devil's shrub, shigoka, touch-me-not, or wild pepper. Siberian ginseng is an adaptogen. Athletes use it to improve endurance and reduce fatigue. It is also used to treat chronic heart conditions, ADHD, high blood pressure, diabetes, kidney disease, colds and flu, among other conditions. Key Takeaways: "There are seven primary eleutherosides in eleuthero, with eleutherosides B and E being the most frequently studied. Siberian ginseng also contains complex polysaccharides, which are a main reason for its ability to boost the immune system." Read more: https://draxe.com/eleuthero-siberian-ginseng/
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Date:
August 30, 2018 09:53 AM
The damage that is being done to young people's livers is rising at an exponential rate. The amount of alcohol that these people drink is insane and their livers are starting to take some serious damage. It is sad because people learn about the negative effects of alcohol but they still decide to abuse it. The lasting effects that occur on their bodies are really bad and they are things that many people struggle with for many years. Key Takeaways: "According to researchers, the rise in cirrhosis mortality is entirely driven by excess alcohol consumption by young adults." Read more: https://www.healthnutnews.com/liver-damage-is-a-growing-epidemic/
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Date:
July 11, 2018 05:54 PM
A human's body is remarkable at ridding the digestive tract of toxins and wastes. But what happens when a digestive system is not working quite right and not clearing the waste as it is supposed to do? Here are 7 signs that your body has pounds of waste in it. If you're especially tired, have foul breath despite frequent brushing, overweight, suffer from allergies, can't sleep, can't concentrate and suffer from acne then you might be harboring too much waste. Key Takeaways: "When the colon becomes inundated with excess waste and toxins, it allows harmful compounds to make their way through the gut wall and into your bloodstream." Read more: https://www.thealternativedaily.com/7-signs-you-have-pounds-of-waste-in-your-colon/
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Date:
January 22, 2018 10:59 AM
Home remedies to treat gingivitis. Gingivitis a form of periodontal disease that causes inflammation and infection that destroys the gums which support the teeth. Gingivitis is caused by the long term plaque build up on teeth. Some other contributing factors that can cause gingivitis are other bodily infections, systemic, crooked teeth, poor dental hygiene, uncontrolled diabetes and other factors. Aside from what the dentist can do to handle gingivitis you can try these five home remedies. First you can rinse and soak your mouth with 120 ml of warm water mixed with salt to kill microorganisms. Second you can mix lemon with warm water and rinse and soak your mouth with it. Baking soda and hydrogen peroxide mixed and then used to brush your teeth is another remedy that will help with odor and remove plaque. Be careful not to abuse this remedy because it will negatively effect your teeth. The fourth remedy is to eat an at least a quarter apple in the morning or after eating a meal. The fifth remedy is to rub aloe vera on your gums several times a day to sooth and refresh. You should also brush your teeth twice a day and Frequently visit your dentist.
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Date:
November 25, 2017 07:59 AM
Type 3c diabetes is frequently being misdiagnosed as type 2 diabetes. This serious misdiagnosis is causing many patient to fall critically ill. As the doctor's treatment plan for type 2 diabetes isn't the right treatment path for type 3c diabetes. Type 3c diabetes is also called pancreatogenic diabetes. The inflammation and excessive tissue growth of the pancreas contribute to the onset of this serious condition. The wrong diagnosis can cause adverse medical conditions, both short and long term, for the patient involved. It is of vital importance that the medical profession inform themselves about this condition to avoid serious health risks from misdiagnosis to their patients. Key Takeaways: "Our research shows that the majority of people with type 3c diabetes are being misdiagnosed with type 2 diabetes, putting both their short and long term health at risk" Read more: https://www.naturalnews.com/2017-11-21-experts-warn-there-is-a-new-variant-to-metabolic-problems-type-3c-diabetes-is-being-misdiagnosed-which-is-why-many-arent-responding-to-treatment.html
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Date:
November 13, 2017 03:59 PM
Type 1 diabetes differs from type 2. First of all it is not caused by obesity or an outside factor. It is often gentic. If your parent has it you may also get it. Even children can get it. It can be controlled but first has to be diagnosed. Here are some signs to look for which might tell you you have it. If you think you do go to a doctor as soon as you can for tests. Key Takeaways: "Suddenly, someone might have unexplained weight loss, constant thirst, and the need to go to the bathroom all the time." Read more: http://www.health.com/type-1-diabetes/type-1-diabetes-symptoms
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Date:
October 02, 2017 10:14 AM
Skin tags, also known as acrochordons amongst the medical community, are noncancerous fleshy growths and are largely a cosmetic issue. They often grow where a lot of friction and moisture occurs. Many people seek to have them removed, and you can do this safely in a number of ways, including at your doctor's office with a scalpel. Cryotherapy can also be used, as well as cauterization, where the skin tag is essentially burned off, tying a string around it to cut off blood supply, and laser removal. However, these all require a doctor's supervision. Some natural at-home remedies can be used as well, such as apple cider vinegar, tea tree oil, oregano oil, iodine, garlic, vitamin E, the peel of a banana or papaya, castor oil and baking soda, and cinnamon. You can also prevent further skin tags by keeping your blood sugar at a healthy range through diet. Key Takeaways: "The best practices for how to remove skin tags at home do not involve cutting; this is dangerous and may lead to a severe infection and permanent scarring." Read more: https://draxe.com/how-to-remove-skin-tags/
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Date:
August 12, 2017 04:14 PM
When it comes to nutrition and health benefits, brown rice is the superior option over white rice. Brown rice is less processed than white rice, and it also boasts a higher level of vitamins and minerals as well as greater fiber content. Brown rice carries a number of health benefits with it and nutritionists say it strengthens cardiovascular, digestive, and bone health. Additionally, it lowers cholesterol and helps to prevent diabetes. Brown rice benefits one’s waistline as well, as it keeps the stomach feeling full while also providing the body with energy. Key Takeaways: "Recent studies suggest that eating cereals high in fiber and low in glycemic content such as brown rice reduce the risk of developing metabolic syndrome." Read more: http://food.ndtv.com/food-drinks/9-health-benefits-of-switching-to-brown-rice-1730477
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Date:
July 20, 2017 04:14 PM
There are always new fads where weight loss is concerned. Everyone wants to find new things to try. They want things to be more modern. Maybe this is not the right outlook, though. Maybe they should look at what their grandparents did because things seemed to be easier then, though there were fads back then too. The fads weren't as easy to find, though. Sometimes looking at previous generations can help us solve health and other problems. Key Takeaways: "Research also shows timing and frequency of meals effected weight loss. One big meal and two smaller meals with no snacking works the best." Read more: http://www.wwl.com/media/audio-channel/did-our-grandparents-have-it-right-when-it-concerns-weight-loss
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5005)
Date:
July 16, 2017 04:14 PM
Migraines are a terrible affliction for many people around the world. Usually, people go for the Tylenol, Advil, or a similar drug to escape their horrible pain. Recently, studies have confirmed that migraines could be better managed by the cannabis compound. There was a test done with 79 people that regularly suffer from migraines or cluster headaches. It found that many more were receptive to the cannabis compound than typical drugs for their headaches. Marijuana treatment led to fewer and less frequent migraines. Key Takeaways: "Past research has shown that cannabis can help migraines thanks to its ability to target the cells in the body that are responsible for controlling inflammation and relieving pain." Read more: http://www.naturalnews.com/2017-07-05-cannabis-compounds-found-to-be-superior-to-migraine-drugs.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4985)
Date:
July 15, 2017 12:14 PM
There are 20 essential oils for muscle pain and how to use them. Getting aches and pains in your muscles is a fact of life. The more we use our muscles, the more tired we get. As we age, this gets worse and worse. Aging also poses problems for our movement. That makes arthritis symptoms more likely to develop. Lavender is one of the essential oils for muscle pain. It helps out quite a bit. Rosemary is another one. Key Takeaways: "Getting muscle aches and pains is a fact of life. The more we use our muscles, the more tired and fatigued they get, and unfortunately as we age this occurs more frequently and recovery takes longer." Read more: http://www.belmarrahealth.com/20-essential-oils-muscle-pain-use/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4977)
Date:
July 14, 2017 09:14 AM
Hand mouth and foot disease is a common disease among small children, although can be present in all ages. Its a disease spread by bodily fluids, like that from the mouth, nose, and even feces. The disease starts as showing no symptoms, but after 3-5 days, sores may begin to appear. As they burst, they scab over and vanish. There is no known treatment for this disease, although it isn't life threatening. Within 7-10 days, it is over. However, for up to 5 weeks after the infection, someone is still capable of spreading the disease. Key Takeaways: "Hand, foot and mouth disease is frequently found in childcare settings where frequent diaper changes and potty training allows the virus to spread quickly from person to person." Read more: https://draxe.com/hand-foot-and-mouth-disease/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4968)
Date:
July 08, 2017 04:14 PM
Kombucha is a fermented black or green sweet tea drink that originated two thousand years ago in the Far East. Within this fermented drink, there exists a scoby-- or colony-- of bacteria and yeast. The probiotics within this drink are believed to aid digestion. Kombucha also contains vitamins, minerals, and antioxidants. In addition to aiding digestion, Kombuncha is reported to boost memory and promote heart health. It is also reported to protect the immune system, the eyes, and the joints and cartilage. Key Takeaways: "The probiotics from this live bacteria and yeast are one of the reasons that people think Kombucha is good for your digestive system." Read more: https://www.sdentertainer.com/drinking/health-benefits-of-kombucha/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4944)
Date:
May 22, 2017 03:44 PM
Encountering successive gut minutes is something we as a whole have needed to manage eventually in our lives, regardless of whether it was because of awful sustenance or an especially terrible ailment. With more genuine conditions, visit inside minutes are simply one more giving manifestation that harmonizes extra indications of muscle throbs, fever, and a general sentiment being unwell. At the point when sustenance is devoured, it is your stomach related frameworks employment to separate it and concentrate the greater part of the fundamental supplements from it. Key Takeaways: "Frequent bowel movements not caused by an infection or any sort of abnormal pathology are dependent on several factors, including food intake, liquid intake, and fiber intake." Read more: http://www.belmarrahealth.com/frequent-bowel-movements-causes-stop/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4670)
Date:
May 20, 2017 03:44 PM
This oil is made from marijuana. The argument about it is raging because many want it to remain illegal but it supposedly has good medical benefits. This gives info about a person who took this oil for a month. They tell their experience with it and what they liked. It gives a good perspective since it comes from someone's hands-on experience instead of just conjecture. Reading this might make you think differently about the medical marijuana issue. Key Takeaways: "CBD, or cannabidiol, is available as a supplement and comes from the same cannabis plant as the stuff you would smoke, but contains only trace amounts (less than 0.3 percent) of THC—the chemical component that has psychoactive effects." Read more: https://www.mindbodygreen.com/articles/why-i-regularly-take-cbd-oil
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4654)
Date:
May 17, 2017 08:45 AM
If you have diabetes, you'll need to learn about and control several factors in your life if you want to control your blod sugar. Eat low carb, small portion meals timed around when you need your medicine. Stay hydrated and avoid sugary drinks. Develop an exercise plan with your doctor, then make an exercise schedule to incorporate it into your life. Frequently check your blood sugar, store your insulin propertly, and keep your doctor updated on any changes. Don't make changes to your diet or your insulin intake when you are ill. Talk to your doctor before drinking alcohol. Watch for cycles of erratic blood sugar during menstruation or if you have menopause. Lastly, log your stress level every time you take your insulin. Key Takeaways: "As much as possible, plan for every meal to have a good mix of starches, fruits and vegetables, proteins and fats." Read more: http://www.mayoclinic.org/diseases-conditions/diabetes/in-depth/diabetes-management/art-20047963
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4632)
Date:
May 12, 2017 11:44 AM
Heartburn is very common, especially after consuming a greasy meal. However, sometimes heart burn can signal something else, specifically GERD or acid reflux. When stomach acid flows back into your esophagus, one experiences acid reflux. Furthermore, when these acid reflux symptoms become constant and common it turns into GERD. It is important to know the facts about both acid reflux and GERD and also very important to discuss any problems you experience with your physician. Key Takeaways: "A good rule of thumb is to make an appointment when you experience frequent or severe heartburn that doesn’t go away with over-the-counter medication." Read more: http://www.pfizer.com/news/featured_stories/featured_stories_detail/when_it_s_more_than_just_heartburn
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4597)
Date:
April 18, 2017 03:44 PM
Who doesn't love sugar? In amounts great or small, and in a wide array of foods, sugar is one of the most important ingredients of food that our taste buds recognize. However, there is a dark side to this sweet substance. We know about the dangers of becoming overweight, or the threat of diabetes, but did you know that cardiovascular disease is another serious side effect from the intake of sugar as part of your diet. Key Takeaways: "Sugar has a bittersweet reputation when it comes to health." Read more: http://www.health.harvard.edu/heart-health/the-sweet-danger-of-sugar
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4429)
Date:
March 25, 2017 08:44 AM
As legalization becomes more widespread in the United States, our understanding of the complexity of the effect of cannabinoid use is improving. A British pharmacology journal published a study in 2010 that examined sex related differences among marijuana users. For example, men tended to use more frequently, more heavily, and experience more often the binge food craving effect of weed. Women it seems may feel many of the physical effects more acutely then men. Genetics and hormones play a role in our health and behavior, and it appears they impact the effects of marijuana as well. Key Takeaways: "Regardless of how you feel about its use as a recreational substance, evidence is strong that marijuana has significant medical benefits for a wide array of conditions." Read more: http://www.thealternativedaily.com/how-marijuana-impacts-males-and-females/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4284)
Date:
March 23, 2017 11:14 AM
Using a certain oil on your hair, eyelashes and eyebrows can help you grow your hair rapidly. The only way to know, is to do it yourself and see the results. Many people put so much time and money into their hair. Women do this way more Frequently. The are you give your hair tells a lot about the care you give yourself. Key Takeaways: "It is quite normal for many people to invest a lot of time and money in fixing their hair. Especially women do this more Frequently. This is because having long, healthy and shiny hair, makes them look much more beautiful than they already are."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4268)
Date:
March 21, 2017 04:44 AM
Studies show that certain foods are the best snacks to eat close to bedtime. These include high fiber foods such as oatmeal and fruits. Low fat dairy products are also good. Crackers and cheese, sliced vegetables and cottage cheese are also good choices. One must remember that a great deal of calories are consumed by snacking so one must be careful. Maybe it's not really hunger but thirst one is feeling. It is a good practice to drink plenty of water and eat more often during the day so you won't feel like you're starving. Key Takeaways: "A banana, apple or other fresh fruit, a small portion of low-fat cottage cheese or plain yogurt with sliced fruit, or oatmeal or some other high-fiber cereal with skim milk were frequent suggestions made by experts interviewed for this article." Read more: https://www.nytimes.com/2017/03/17/well/eat/what-are-the-best-snacks-before-bedtime.html?partner=rss&emc=rss&_r=0
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4243)
Date:
March 20, 2017 06:44 AM
If you drink one thing in bed before getting up to drop weight, you can reduce inflammation and more. If you have very rushed mornings, then it can be quite a challenge to slow down and take care of basic things like hydration. If you want to try this amazing recipe, then you will make it before you go to bed. Key Takeaways: "But what if slowing down and drinking this elixir before you even got out of bed could improve your morning routine, your mood and your waistline?" Reference: //www.thealternativedaily.com/drink-lemon-water-to-lose-weight/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4230)
Date:
March 20, 2017 04:44 AM
Everyone who has tried to remove a stain also knows how hard they are to remove. There are so many different products on the market which claim to remove stains, some work better than others. Most, if not all, commercial stain removers offered on the store shelves contain toxic chemicals which could harm you, your family, or your pets. Besides the danger of a small child or pet drinking a liquid cleaner, there are dangers due to inhalation or skin exposure during normal use. The solution to this problem is to use a simple, natural, non toxic alternative. Simply mix 3.3 ounces white vinegar, 3.3 ounces liquid salt, 3 and 1/3 ounces mineral water and put the mixture into a clean spray bottle. Spray the solution on the stain, leave to soak for 15 minutes and then scrub the stain with a brush. Older stains may need a longer soak or you may repeat the process until the stain is removed. Key Takeaways: "Stains are created Frequently in our everyday life, as we stain or clothes, furniture, and even car seats."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4228)
Date:
March 18, 2017 08:44 AM
Watchful waiting is a common course of treatment for an ear infection. The discomfort of an ear infection however, takes a toll on both the patient and their families, frequently leaving people searching for alternative treatments. Mayo clinic published a summary of the current understanding of several popular alternatives promoted to relieve the pain of ear infection. Homeopathy, chiropractic, natural sweeteners, and herbal ear drops are few popular therapies with unclear research results. The practicality, cost, and safety of any alternatives should be considered. Key Takeaways: "Alternative ear infection treatments abound on the internet and in books and magazines. They include chiropractic adjustments, homeopathy, herbal eardrops and others." Read more: http://www.mayoclinic.org/diseases-conditions/ear-infections/in-depth/ear-infection-treatment/art-20047613
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4200)
Date:
March 12, 2017 05:14 AM
Garlic is not only used for restaurant use, but also for helping those who have sickly bodies or those who are sick. Garlic could help those who are sick with it's multitude of chemicals that are in the garlic. Now the way to eat the garlic is to mash up to 3 cloves of garlic a day, and eat them without any side preparations like grilling them to get the best effects out of eating garlic. Other's might think that garlic is too smelly or gives you bad breathe, but that is easily counteracted by eating certain mints and leaves as well as drinking coffee. Key Takeaways: "We all know it is very healthy to eat garlic and now we know how to consume it and to take from it it's maximum healing powers."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4113)
Date:
March 12, 2017 04:59 AM
Garlic is not only used for restaurant use, but also for helping those who have sickly bodies or those who are sick. Garlic could help those who are sick with it's multitude of chemicals that are in the garlic. Now the way to eat the garlic is to mash up to 3 cloves of garlic a day, and eat them without any side preparations like grilling them to get the best effects out of eating garlic. Other's might think that garlic is too smelly or gives you bad breathe, but that is easily counteracted by eating certain mints and leaves as well as drinking coffee. Key Takeaways: "We all know it is very healthy to eat garlic and now we know how to consume it and to take from it it's maximum healing powers."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4112)
Date:
March 11, 2017 03:59 AM
Are you getting the D? Vitamin D plays a critical role in your good health and well-being, and a lack of this nutrient can impede your lifestyle in so many ways. It is time to learn the importance of Vitamin D and how amazingly it works to keep you in the best of health possible. If you're not getting enough of the D, it is time to change that. After you learn the benefits, you'll be excited to make these changes. Key Takeaways: "Various benefits are touted, some appearing quite outlandish, and their exaggerated claims often have no scientific backing." Read more: https://www.google.com/url?rct=j&sa=t&url=http%3A%2F%2Fwww.miningjournal.net%2Flife%2F2017%2F03%2Fvitamin-d-plays-essential-role-in-health%2F&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNGba_nWcdt4N_0QAfF46Q8-hksvig
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4100)
Date:
March 08, 2017 01:59 PM
While many parents are learning to stop using hand sanitizer, a man named David Whitlock, who has not showered in 10 years, has created an after-cleansing spray called Mother Dirt designed to replenish helpful bacteria. When the majority of bacteria is removed from our bodies, what comes back is the "bad" kind, unlike what is naturally there. Soap and detergent can do more harm than good, as most children need little more than tap water, and things like disinfectants in dishwashing soap or overwashing hands can be equally dangerous. Even so, nature can be dangerous, and the healthiest dirt comes from rural areas, and farm animals are still dangerous to immunocompromised childen. The five second rule seems to be scientifically proven, and tested frequently, by Mr.Whitlock. Key Takeaways: "A lot of what keeps the nasty stuff away is having the good and friendly stuff on your skin." Read more: https://www.yahoo.com/news/what-a-guy-who-doesnt-shower-can-teach-your-kid-183347435.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4085)
Date:
January 29, 2017 10:59 AM
Inflammation can be a good sign when there is a cut or infection. It means the body is working to fight against whatever is attacking your body. However, inflammation that occurs for too long or Frequently can cause more damage to you than the problems it fights against. If you want to avoid chronic inflammation that can slowly destroy your body, you should make sure to consume anti-inflammatory foods that help prevent it. Orange juice, virgin olive oil, blueberries, whole grains, cruciferous vegetables, and tomatoes have all been shown to have anti-inflammatory properties. Key Takeaways: "Virgin Olive Oil is a staple food in Mediterranean diet." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3846)
Date:
January 13, 2017 07:59 AM
When it comes to deficiency's there are many different signs that can tell you whether or not you have a vitamin deficiency in general. Some of these signs for knowing whether or not you have a vitamin deficiency include brittle hair, diarrhea, Frequent bone fractures, and lastly having high blood pressure, as well as a deficiency in potassium. Key Takeaways: "A rich or decadent meal can lead to a loose bowel movement, but persistent episodes of diarrhea may be evidence that the body is not retaining nutrients." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3776)
Date:
December 31, 2016 10:59 AM
The study included 89,000 middle-aged men and women who were followed for up to 13 years. At study entry 68 percent of the men and 11 percent of the women were regular drinkers. The analysis was confided to the men because the number of female drinkers was so small. The investigators found that men who drank relatively heavily on most days of the week had a heightened risk of dying from any cause. In contrast, men who drank roughly the same amount alcohol each week, but drank less Frequently, showed no increase in their mortality risk. The findings, which appear in the American Journal of Epidemiology, give some credibility to the widespread social belief in Japan that a "liver holiday," a few days off from drinking each week helps counter the ill effects of alcohol. Key Takeaways: "To keep your liver’s clock consistent this holiday season, avoid extreme behaviors" Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3722)
Date:
December 22, 2016 06:39 PM
It is estimated that 90% of humans are deficient in one or more essential vitamins and minerals. While some may be due to inadequate absorption, most is believed to be due to poor nutrient intake. Vitamin B12 and vitamin D have been identified as two of the worst deficiencies. Although nutrient needs should be met primarily by diet, there are supplements available if the diet doesn’t allow for a proper balance. A multivitamin may be recommended for most people who are at risk of a deficiency. Key Takeaways: "Evidence clearly shows that many Americans obtain less than the required amounts of a number of vitamins and minerals, and that dietary supplement use increases intakes and reduces rates of nutritional inadequacies." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3686)
Date:
December 20, 2016 07:59 AM
Research has shown that Turmeric has many health benefits. Studies have shown that not only does it have a significant anti-inflammatory properties but it’s compound curcumin has been linked to reducing tumor size and killing cancer cells. Turmeric is also being linked to other health benefits, such as, helping with diabetes, lowering blood sugar and helping with arthritis pains. Key Takeaways: "There are many herbs that draw attention in medical literature, one of the most Frequently mentioned is turmeric." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3675)
Date:
December 16, 2016 10:59 AM
Keeping yourself in a healthy weight range is very important. It can ward off disease and different types of cancer, but it is easier said than done. There are some tips to help lose weight this season. Brushing your teeth after you eat can aid in weight loss, and also making sure the changes you make are not too drastic can help keep you motivated to lose weight. Key Takeaways: "Weight loss doesn’t start at the dinner table or even at the grocery store; it starts in the kitchen" Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3657)
Date:
December 16, 2016 08:59 AM
Having high cholesterol can lead to major problems. It is important to watch cholesterol levels and there are a few things you can do to limit the damage cholesterol can do. Exercising regularly and making sure you limit your alcohol intake are important steps to take to protect yourself from a heart attack or even a stroke. Key Takeaways: ""Alcohol should be consumed in moderation. Occasional drinks at a bar or cocktail party may not raise your LDL levels, but if these outings happen too Frequently, it could spell trouble. Did you know that consuming large amounts of alcohol can lead to a stroke, heart failure and high blood pressure?"" Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3656)
Date:
December 16, 2016 06:59 AM
Turmeric, the main spice in curry, is arguably the most powerful herb on the planet at fighting and potentially reversing disease. It has so many healing properties that currently there have been 6,235 peer-reviewed articles published proving the benefits of turmeric and one of its renowned healing compounds curcumin. This puts turmeric on top of the list as one of the most Frequently mentioned medicinal herbs in all of science and the next most popular studied herbs include garlic, cinnamon, ginseng, ginger and milk thistle. Key Takeaways: "The bright yellow spice is not only an important antioxidant, but it is also an anti-inflammatory, soother of irritations and a skin brightener." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3654)
Date:
December 07, 2016 08:59 AM
Type 2 diabetes is a dangerous disease that becoming alarmingly Frequent. If you're over the age of 45, have a family history of type 2 diabetes, high blood pressure, or any of the other common risk factors, some easy lifestyle changes like a proper healthy diet and adequate exercise can help keep type 2 diabetes at bay. Key Takeaways: "Insulin plays a crucial role in delivering glucose, or sugar, into the cells. This glucose is then used for energy." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3588)
Date:
November 29, 2016 12:59 PM
People are so busy these days that they are always looking for the “easy way out” when it comes to treating problems. Why alter your diet when you can just buy a specially formulated shampoo to treat your hair issues? Companies count on us needing something so badly that we will buy anything as long as it says the right thing on the bottle. In reality, a healthy diet is the best thing we can do for our hair. Fruits and vegetables are particularly useful due to their high amount of vitamins and minerals. Key Takeaways: "Most of us are aware that vitamin C can help boost our immunity, protecting us against Frequent colds and other infections." Reference: //food.ndtv.com/beauty/5-vitamins-for-hair-how-to-reduce-hair-fall-1596296
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3532)
Date:
November 22, 2016 08:59 AM
A recent study performed on United States military veterans has found a link between people that have Frequent constipation and those that develop chronic kidney disease and kidney failure. So far, the reason for the connection is unknown, but researchers calculated that people with Frequent constipation have a 13 percent higher risk of kidney disease and a 9 percent higher risk of kidney failure. Key Takeaways: "Researchers reviewed the medical records of 3.5 million United States military veterans who had normal kidney function at the start of the analysis." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3486)
Date:
November 19, 2016 02:54 PM
If you are one of the millions of people worldwide who suffers from alopecia, there are some things you can do to try bringing back that beautiful head of hair. These things do not work for everyone, but are always worth a try. Smoking, some prescription medications, stress, and alcohol can all have adverse effects on the hair. These, along with Frequent hair treatments and tight hairstyles, should be avoided as much as possible to keep the hair nice. Just like the rest of the body, hair needs the proper balance of nutrients to survive. Key Takeaways: "Naturally, this includes vitamins and minerals. Many of them are essential to ensure the health of the follicle, the papilla and its matrix, and the hair that grows from it." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3472)
Date:
November 19, 2016 12:49 PM
We have all felt the 2 o’ clock energy slump. What can we do to prevent it? Most people think that loading up on caffeine during the day to keep them awake is the answer. In reality, this can create a never-ending cycle that is bad for us. The best things we can do are eat a balanced diet rich in calcium and B vitamins and get the right amount and quality of sleep. Just eating healthier is not enough, however. It is also best to eat smaller, more Frequent meals to keep us powered throughout the day. Key Takeaways: "An energy-optimal meal or snack includes a mix of high-quality carbohydrates for energy with some lean protein and healthy fat for staying power." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3471)
Date:
November 19, 2016 08:12 AM
In many ways, pain meds such as Acetaminophen and Ibuprofen have provided countless patients with an inexpensive treatment for regular aches and pains, headaches and migraines, and to help deal with fevers. There's no doubt that these painkillers work, but there are doubts whether their positive side effects outweigh the negative. Liver damage is a common problem, damage that can't be repaired or reversed. One of the main side effects that manifests within children taking either Acetaminophen or Ibuprofen is known as Reye Syndrome, a condition that produces excessive fat deposits around the child's organs (especially their liver). This condition can result in death as pressure can build up to fatal levels around the child's brain. Other organ damage related to Acetaminophen and Ibuprofen usage includes inflammation within the kidneys (leading eventually to their complete deterioration) and hyperthyroidism. Higher doses of pain meds can increase the danger of bleeding or torn stomach lining by several times. Stomach problems are also often noted within regular users of these over the counter pain meds. While bleeding ulcers tend to be the most commonly discussed issue within the media, other problems include heartburn, indigestion, bloating, diarrhea, nausea, Frequent and unavoidable burping and vomiting. Indeed, severe reactions to these painkillers can even cause a cerebral edema, a condition where excess water floods around the brain, causing anything from migraines to death. These are some the many side effects and negative conditions associated with significant usage of over the counter painkillers. While it's clear that many people use Acetaminophen and Ibuprofen for extended periods of time without developing serious side effects, it's also clear that the potential dangers of regular and prolonged use need to be taken into consideration. If you are already at risk for any of the above problems, and if you are currently on any Acetaminophen or Ibuprofen medications, you should consult your doctor.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3468)
Date:
November 03, 2016 10:02 PM
Our bodies have a defense mechanism called immune system designed to protect us against unknown invaders that attack our body. Immune system is a system of biological structures and processes guarding us against illness. It identifies a wide array of foreign agents such as viruses, parasitic worms, bacteria, microbes, toxins that invade our body and differentiates them from healthy tissues. Some products available over the counter are known to improve immune system. Even though, few of these products are not trustworthy several of these supplements have known to improve immune systems drastically. They enhance immune cells in the body resulting in a better performing immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3383)
Date:
November 02, 2016 10:49 AM
Mention pumpkin and you think Halloween jack o’lanterns. Come Thanksgiving or Christmas, it’s pumpkin pie. Or maybe pumpkin soup. Yet nobody talks of the two powerhouse nutritional part of the pumpkin – pumpkin seeds and pumpkin seed oil. From improving bladder function, easing arthritis to thwarting heart disease and providing anxiety relief, it’s the seeds where the magic of the pumpkin is. Key Takeaways: "a condition characterized by a sudden urge to urinate that may lead to an involuntary loss of urine Researchers estimate that 16 percent of men and women suffer from overactive bladder symptoms such as urination urgency as well as Frequent daytime and night urination." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3374)
Date:
September 20, 2015 04:40 PM
Although occurring more Frequently among women, bladder infection can also turn into a serious health condition among men when left untreated. Bladder infection is commonly caused by E.coli infection, although other factors like pregnancy and trauma can contribute to its development. Aside from proper personal hygiene and overall healthy lifestyle, taking natural supplements can also be helpful in preventing bladder infection. Natural Supplements for Bladder Infection Prevention While vitamins and minerals found in the food you eat everyday play an active role in strengthening your immune system, there are only a few nutrients which are specifically effective in preventing bladder infection. These include the following: In recent years, cranberry supplements have been used to prevent Diabetes Mellitus and Cancer. Primarily, these types of supplements are used even in the olden times as a preventive measure for various urinary tract disorders like bladder infection. Experts originally believe that cranberry supplements prevent bladder infection by making the urine acidic, thus, rendering the environment an unlikely place for bacterial growth. However, they discovered that cranberry supplements work by preventing bacteria from sticking into the lining of the bladder. Cranberry supplements are proven effective in preventing but not treating bladder infections. Compared to cranberry supplements, Lingonberry supplements are less popular as an effective measure to prevent bladder infection. The nutrients found in Lingonberry help prevent urinary tract infections and is also effective in treating gout and arthritis. There are several theories on how these supplements prevent bladder infection but the most accepted scientific explanation is that the compounds found in Lingonberry are effective in killing the bacteria that causes infection in the urine. Conclusion Most cases of bladder infections are considered mild and can be treated with ordinary health remedies like increasing fluid intake. Proper diagnosis and prompt treatment, however, is necessary when symptoms become intense. Stop bladder infection before it happens. Use natural supplements to avoid bladder infection. References //www.webmd.com/vitamins-supplements/ingredientmono-958-CRANBERRY.aspx?activeIngredientId=958&activeIngredientName=CRANBERRY&source=0 //www.webmd.com/vitamins-supplements/ingredientmono-813-LINGONBERRY.aspx?activeIngredientId=813&activeIngredientName=LINGONBERRY&source=0 //doctormurray.com/health-conditions/bladder-infection-cystitis/
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Date:
September 03, 2015 01:59 AM
Prostate health is vital for any male's well-being. Keeping your prostrate free from complications is a result of good hygiene, proper diet and most importantly, living a healthy lifestyle. The bad news is that some of the prostate complications such as prostate cancer can cause death. The good news is that there are better remedies to prevent that from happening, reduce the effects of these complications and lastly, do away with them completely. From pharmaceutical pills to natural supplements, there are more than enough remedies for prostate complications in the market. However, if you are looking for something safe to use, then it is always advisable to choose natural supplements, herbs or anything that is safe from toxic chemicals. In our case, we will be dealing with herbs that support prostate health. What Herbs Support A Healthy Prostate? In summary, keeping your prostate healthy means improved urination flow and more. It also means, creating a barrier between your prostrate and several diseases such as prostate cancer. The herbs mentioned above are among the best and the safest ones to use. References:
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Date:
August 17, 2015 05:40 PM
Garcinia cambogia, a tropical fruit obtained from a herb called Malabar tamarind, has for a long time been used as a weight loss supplement. Garcinia cambogia is found to grow naturally in South East Asia and some parts of Indonesia. Traditionally, this herb was used as food flavor by traditional communities in India. The fact that this supplement is obtained naturally implies that it has minimal side effects when used for weight loss by an individual. How does Garcinia cambogia works? The critical component that gives Garcinia cambogia its weight loss property is called hydroxycitric acid or simply HCA. Garcinia cambogia works through; What determines the success of Garcinia cambogia in any weight loss program is the concentration of HCA. The recommended HCA concentration that you should buy is 60%. Moreover, it is also imperative to consider shopping for the Garcinia cambogia products that are certified and approved by the Food and Drug Administration. This is to ensure that what you are shopping is safe and suitable for all your individual weight loss needs.
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Date:
August 12, 2015 08:24 PM
Selenium is nature’s best secret. It is a nutrient that when used in the correct amounts in your food, can make huge and exciting changes. However, the body only needs small amounts of this mineral, but it has huge benefits on one’s health. It protects us against many health problems that are associated with the aging process such as osteoarthritis and cancer. A certain amount of this mineral is required in order to protect the body from deadly viruses and also to aid in healthy thyroid functioning. Selenium deficiency Frequently goes untreated simply because it does not show any noticeable symptoms. If the levels of selenium are low, the thyroid will have to work extra hard to manufacture its hormones and the body will have a tough job converting those hormones to a form the cells can use. This is because selenium is a chief ingredient of the molecules necessary for the body to be able to create and use seleno-proteins (thyroid hormones). The initial stages of low selenium levels will reduce the optimal production of the thyroid hormone in the glands. If this continues the thyroid gland becomes inflamed. Eventually, this is what leads to thyroid autoimmune problems Problems that come with low selenium levels can be more serious when the levels of mineral, iodine, is low. Iodine is well known for its key role in thyroid health. Selenium is also important in aiding your body to recycle iodine. Low selenium levels coupled with low iodine levels can lead to thyroid imbalance An enlarged thyroid is known as goiter. This is one of the serious forms of thyroid imbalance. Most individuals diagnosed with goiter usually have low iodine levels, however research has also shown that the patient also have low levels of selenium. Therefore, it is very important to treat both deficits so as to re-establish thyroid stability Doctors readily admit that there is no any specified dose of selenium required for better functioning of the thyroid. The one thing they agree on is that optimizing selenium intake aids in general health. References //www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=0CDYQFjAEahUKEwih0urP8KPHAhXHOBQKHfIrC3w&url=http%3A%2F%2Fwww.nlm.nih.gov%2Fmedlineplus%2Fdruginfo%2Fnatural%2F1003.html&ei=8GjLVaGaCsfxUPLXrOAH&usg=AFQjCNHzSWE2P10XlrjScWz9oE6KOYZFdA&bvm=bv.99804247,d.d24 //www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=0CE4QFjAIahUKEwih0urP8KPHAhXHOBQKHfIrC3w&url=http%3A%2F%2Fpatient.info%2Fdoctor%2Fselenium&ei=8GjLVaGaCsfxUPLXrOAH&usg=AFQjCNEjLPYH8bzUP0K2eUgEAAR7HIrZAg&bvm=bv.99804247,d.d24
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Date:
October 31, 2014 06:05 AM
Do you want to get some information about Magnesium? Magnesium has been found to be working in other ways to contribute in preserving the nervous system. Before the end of 20th Century, specialized doctors had established that injection of magnesium in our bodies exerts a depressant effect on the nerves. In fact, the main use of this mineral in early times was to induce sleep. Significantly, any hibernating animal have high levels of magnesium. The mineral has also shown effectiveness in control of convulsion in pregnant women, the shakes in alcoholic and epileptic seizure. MAGNESIUM CALMING THE NERVOUS SYSTEM One of paradoxical effect is that, a magnesium deficient person who end up taking magnesium will feel energetic than never before yet the mineral is not a stimulant but rather a depressant. Actually, magnesium normally relieves the irritability of nervous system and the excessive energy, which will result to fatigue. With this, it will not be surprising to say that when an individual magnesium levels is sub-normal then the nerves will not be in a position of controlling functions such as muscle movement, mental processes and respiration. Irregular heartbeat, twitching, irritability and largely nervous fatigue are the most Frequent symptoms of magnesium depletion. Often, deficiency of magnesium is because of failure on individual side to obtain to use dietary sources such as eggs, wheat germ, green vegetables, cocoa, almonds, soybeans, desiccated liver among many other. However, in some instances, coexisting illness can impair absorption of this mineral, for example the intestinal infections. In such an instant, ingested magnesium may be lost completely in the body and majorly in the nervous system. PENN of Columbia University published the information of essential of magnesium to nervous system first in 1966. He studied the conduction of electricity by the nerves. The main finding was that calcium is the prime conductor mineral of the electrical current. It was concluded from the finding that Magnesium would in turn maintain the required level of calcium in the nervous system. Actually, Magnesium is Do you want to get some information about Magnesium? The nutrient that is likely to change your living standards by improving your nerve health. References
1. THE MAGNESIUM ONLINE LIBRARY. 2. // WWW.MGWATER.COM/
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Date:
September 17, 2014 05:25 PM
Maca Root is one of the roots and tuber harvests of higher protein content. Until late years, this nutritious base of the Andes was little or nothing known for the lion's share of the individuals thereof, Peru (aside from the tenants of the Andes) and obviously overlooked by whatever is left of the world. Maca (otherwise called Peruvian Maca or Maca Andina) has an astonishing quality to develop to remarkable statures: from 3800 to 4800 meters high in the most cold Andes mountains, where temperatures are amazing, from exceptional hotness morning to ice on the night, frigid winds, snow and persevering high power of daylight. In this antagonistic region, where there is little oxygen, there is uncommon vegetation develop just potatoes and maca sharp. There are no trees, no plants, just a couple of centimeters tall. This tuber, irrelevant part of the tuberous root size and state of a typical radish, is effectively dried under the sun and keeps up its nutritious qualities, with elevated amounts of iron, for a few years stockpiling. It is brilliant nourishment and Incas additionally utilized it for its richness improving activity and its impact on sexual conduct.
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Date:
August 07, 2014 05:22 PM
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Date:
July 18, 2014 04:42 PM
What is anxiety?
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Date:
July 03, 2014 08:02 AM
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Date:
July 01, 2014 08:50 PM
Allium Cepa was originally native to central Asia; however, nowadays it has a global geographic range. It made its way to Egypt through trade, where it became an important food crop in the ancient world. Because the Allium cepa was a cheap food source, Egyptian slave workers, those who built the pyramids, ate them on a daily basis. Additionally, it was illustrated in the funerary images in tombs. Ancient Sumerians commonly cultivate and cooked Allium cepa 4,000 years ago. Benefits of allium cepa Allium Cepa is extremely valued for its healing qualities. It has been utilized as a food cure from time immemorial. Research illustrates that Allium Cepa may help protect against several chronic diseases. That is possible because the plant contains generous quantities of the flavonoid quercetin. Research has also shown that quercetin guards against cardiovascular disease, cancer and cataracts. Additionally, Allium Cepa contains various other naturally occurring chemicals called organic sulfur compounds, which have been associated with lowering cholesterol and blood pressure levels. Even though the plant is seldom used specifically as a medicinal herb, it has a wide variety of helpful actions on the body and when regularly consumed (particularly raw), it will help the body’s health.
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Date:
June 30, 2014 09:54 PM
Homeopathic remedies
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Date:
June 28, 2014 05:41 AM
Sources
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Date:
May 04, 2014 09:33 PM
What is a turbinado sugar Utilization and storage Formulas that call for turbinado sugar have a tendency to utilize it as a trade for conventional tan sugar. It holds more dampness than customary white or tan sugars, which might be gainful in things like treats or biscuits. Interestingly, one ought not to supplant table sugar with turbinado in formulas that as of recently have a few parts giving dampness, to abstain from making the finished item saturated. It is now and again conceivable to utilize turbinado sugar within formulas like these by lessening the measure of an alternate saturating fixing or utilizing less sugar than is called for, yet it may take some experimentation to get the last item to turn out accurately. Turbinado sugar is a famous fixing for cinnamon treats and toast, and is normally utilized as a part of graham saltine pie-crusts. Gourmet experts might additionally utilize it on creme caramel, since it melts and caramelizes well. Provided for its higher dampness content, it can solidify if presented to a lot of air. Makers suggest putting away it in a hermetically sealed holder in a cool, dull spot. Producing turbinado sugar Turbinado sugar is made by taking the first pressing of juice from sugar stick and gradually warming it to vanish the water out of it. This makes it solidify. To finish the drying process, the precious stones are then spun in turbines or rotators. Conversely, white sugar is regularly substantially all the more vigorously transformed, and is for the most part made white by utilizing a decolorizing channel like bone burn to uproot its characteristic shade. Similarly, much tan sugar is really white sugar with molasses added goes into it to shade it. Benefits of turbinado sugar Some accept that turbinado sugar is a healthier elective to different sweeteners on the grounds that it experiences less transforming, along these lines holds a greater amount of the supplements found in sugar stick juice. What's more, its system for handling makes it suitable for vegetarians, since no creature repercussions are utilized. A teaspoon (about 4 grams) holds around a considerable measure of calcium and potassium not with standing an insignificant measure of iron. A measure (250 g) of this sweetener likewise holds magnesium, phosphorus, and sodium. Comparable Products Different items like turbinado sugar incorporate demerara and muscovado sugar. Both are foul and daintily transformed, yet demerara is much lighter in color than muscovado, and marginally less sodden. Every one of the three can by and large be substituted for one another in formulas, in spite of the fact that muscovado has a ton of dampness and an exceptionally solid flavor, along these lines can some of the time be utilized as a part of more diminutive adds up to attain the wanted impact. In the event that going the other route, from turbinado/ demerara to muscovado, then cooks need to include a tad bit of molasses to the sugar to make it wet enough.
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Date:
April 28, 2014 06:18 PM
Vitamin E can do Vitamin E benefits Quite a while, individuals needed to hold up until the wounding was gone before they could stress over the scarring, and Frequently it was past the point of no return. Numerous wounds are presently maintained a strategic distance from utilizing vitamin E cream instantly. Despite the fact that we all wound occasionally, some wound faster and less demanding than others do. The cream helps the wounding go away faster. The vitamin E cream is exceptionally famous by elderly individuals that regularly wound simpler. They are additionally more inclined to straight forward mischances in the process of a day. The utilization of the cream disposes of the wound faster, as well as helps wipe out the possibility of scarring. What numerous individuals like about the cream, particularly the elderly, is that it is accessible without a remedy. This engages a large portion of the elderly who cannot generally bear the cost of an office visit with their specialist. You've heard about the profits of this Cream for wounds. To numerous individuals, the cream is a marvel cream. One condition that vitamin E creams extremely useful with is insect veins. For a long time individuals have been tormented and disturbed by arachnid veins, feeling there was no assistance or alleviation accessible until they were acquainted with Vitamin E cream. Right away they are thankfully disposing of these terrible imprints with the assistance of it. Contrasted with the cost of numerous different medicines, the cream is an extremely economical cure.
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Date:
April 15, 2014 10:36 PM
Major / Clinical Depression
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Date:
April 09, 2014 11:47 PM
As the adrenal organs affect all body forms, a diminishing in their capacity might be seen practically anywhere. The standard first side effect of LAF is regularly weariness. Individuals experiencing issues getting up in the morning or have spurts of exhaustion at diverse times of the day. Frequently, the following side effect is an inclination of shortcoming, discombobulating or expanded heart rate when climbing from a sitting position to standing. In the event that the issue is not tended to, additional manifestations take after: Cause of low adrenal level With adrenal weariness, your body does not process enough cortisol to keep glucose levels consistent as you experience your normal 8-10 hour when we rest. As glucose levels begin to drop throughout the center of the night, ordinarily your adrenal organs discharge cortisol to help push glucose levels move down. These hormones are Central Nervous System stimulants and will wake you up. This is the reason you may appear to get up, wide up and about. It is critical to take a gander at all the elements that help adrenal weakness and hyperactive action. A sleep deprivation prescription will never alter the center issue in this case. The very situation recently portrayed to you is exceptionally normal. There are numerous variables that must be viewed as including circadian musicality of cortisol discharge, lifestyle components, passionate anxiety, and sustenance sensitivities, in addition to everything else. There is nobody size fits all medication for this syndrome however you can have triumph and overcome you’re a sleeping disorder in the event that you discover a specialist who takes a thorough, all common, huge picture methodology, to this advanced disease called Adrenal Stress Syndrome . Types of adrenal stress syndrome Temperament swings: When the cerebrum isn't getting enough sugar, it doesn't work appropriately. A way the cerebrum builds the breakdown fat into sugar is by creating a solid feeling, for example, indignation or great misery. An individual typically feels better a short time later, in the same way that they will be less passionate in the wake of consuming. Desires of desserts: As the adrenal organs tell the pancreas what amount of insulin is required to process in a dinner, when the adrenal organs are not working accurately, they don't correctly correspond with the pancreas, so a lot of insulin has a tendency to sent by the pancreas for anything consumed subsequently glucose levels drop rapidly after supper; this causes the starch longings. Mental burdens: Anything that causes mental or enthusiastic misery will fortify the adrenal organs to transform substances to help with the impacts of the anxiety (epinephrine, norepinephrine, and serotonin). Delayed mental anxiety, for example, needing to meet a due date, last test of the years, being in an oppressive relationship, and so forth will result in the adrenal organs to need to capacity without enough breaks.
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Date:
March 29, 2014 11:01 PM
In the event that you or your youngster has ever had an awful instance of this season's flu virus, you know how hopeless it might be. Particularly for mothers, it is appalling to see your youngsters feeling so awful and not have the ability to settle it. Dark elderberries (Sambucus Nigra) have been indicated to anticipate influenza and pace recuperation in the individuals who have this season's cold virus. Elderberries hold large amounts of A, B, and C and fortify the resistant framework. Several natural elderberry syrups are accessible at health stores or on the web, yet for the most part for around $15 or more for 4-8 ounces. This formula makes 16 ounces for an expense of fewer than ten dollars and children cherish the taste. They are likewise gentler diuretic, and diaphoretic. Flavonoids, including quercetin, are accepted to record for the therapeutic movements of the elderberry blossoms and berries. As stated by test tube studies these flavonoids incorporate anthocyanins that are influential cell reinforcements and ensure cells against harm. Utilized for its cancer prevention agent movement, to lower cholesterol, enhance vision, help the insusceptible framework, and enhance heart health and for hacks, colds, influenza, bacterial and viral contaminations and tonsillitis. Elderberry juice is utilized to treat an influenza pestilence in Panama in 1995. Most types of Sabcucus berries are consumable when picked ready and after that cooked. Both the skin and mash could be consumed. Be that as it may, it is imperative to note that most uncooked berries and other parts of plants from this family are toxic. Sambucus nigra is the assortment of Elderberry that is Frequently utilized for health benefits as it is the main mixed bag recognized to be non-dangerous actually when not cooked, however it is still suggested to cook the berries at any rate a little to improve their taste and absorbability.
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Date:
March 22, 2014 08:50 AM
Vitamin A helps battle off contamination. It likewise serves to keep your skin smooth and supple. You can get a great deal of vitamin A from your sustenance - with liver meats being the best source. A few vegetables - carrots, broccoli leaves (the leaves, not the stems), sweet potatoes and kale, run a far off second, alongside spread. Dietary vitamin A hails from two sorts of sustenance: * Animal sustenance sources give "dynamic" manifestations of vitamin A - the form can use the vitamin promptly. They are called 'retinoid'. Retinoid are Frequently utilized within skin creams and dermatological pharmaceuticals, as vitamin A is well known for its skin revival properties. * Plants give carotenoids (to illustration beta-carotene). Carotenoids are changed over by the constitution into vitamin A. Beta-carotene is the most widely recognized of the carotenoids. A brilliantly colored intensifies; this is the thing that gives carrots and sweet potatoes their orange shade. "Collaboration" is the point at which two or more substances join to make an impact more terrific than either could perform on its own. All supplements in the constitution have a synergistic impact, and vitamin A is no special case. Assuming that you as of recently have an iron inadequacy that brings about frailty - insufficient oxygen-transporting red platelets that abandons you ceaselessly tired a vitamin A insufficiency too will exacerbate it. Iron and vitamin A supplements taken together for frailty are more viable than either of these taken separately. When you don't have enough zinc in your eating methodology, the figure has a harder time proficiently utilizing vitamin A. The main sign of a vitamin A inadequacy is debilitated vision especially 'night blindness the powerlessness to see well in faint light. Vitamin An is utilized to structure the shades required in the retina for vision, and without enough A, your eyes can't do their employment. Keep in mind when your mother used to let you know to consume carrots so you could see well? There's truth in that old home cure.
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Date:
March 19, 2014 08:06 PM
Sea salt This is actually the cause all of us make use of as well as adore these items in order to this degree; 2. Lifeless Ocean mineral deposits provide alleviation with regard to arthritis discomfort 5. Enhances blood circulation
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Date:
March 06, 2014 09:32 AM
What is arnica You are most likely acquainted with those blasts that a kid in some cases gets on his head, where you see right before your eyes the tremendous knock that starts developing inside minutes. In this sort of circumstance, if Arnica is connected immediately you will be stunned to discover how powerful it is. Notwithstanding being useful for head damages, where it will prevent the knock from developing and will abate the swelling of the wound, it might be utilized for various different a throbbing painfulness. It offers alleviation for wounds or beat up imprints from falls or blasts and for sprains or for appendages that has been over pushed. Arnica can additionally help for wounds that cause discharging or for soreness or firmness from sore muscles or joint inflammation torment; it serves as a mitigating and will help ease the agony. Benefits of arnica Accessible in most health nourishment stores Arnica arrives in a mixture of homeopathic home cures. The cream or gel ought to be connected generously on unbroken skin. It is best if connected promptly after the damage and proceeded three times day by day until the wound is mended. Determine never to apply it to broken or slice skin and never to utilize it inside aside from with bearings from an authorized homeopathic professional. It is incredible for junior kids or children and might be successfully utilized against diaper rash. Kids particularly like it since when connected it doesn't damage or sting and is effortlessly ingested by the physique. With a solution midsection brimming with arranged items, it appears a disgrace to pass up a major opportunity for this key manifestation of easing. It is never amusing to fall and get damage and regardless of the fact that you don't have plays games it is amazing how Frequently mature people crush their leg or get a blast from something, also sore muscles and sprained lower legs. Help yourself out and have Arnica in the medication bureau. You won't be sad and you may even join those that swear by it and bear it all around.
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Date:
February 28, 2014 11:22 PM
Benefits of coconut lotion to skin One of the best lotions for all skin sorts, particularly dry, is coconut oil. It is determined from ready coconut meat and is utilized for cooking and as a grease, Frequently for the skin. There may even be a few profits from the ingestion of characteristic coconut oil. Assuming that you are searching for coconut oil salve, there are numerous spots to discover it. You may run into it on the racks of health sustenance or entire nourishment stores. There are numerous online retailers who offer high quality coconut oil. Likewise numerous tanning moisturizers are enhanced with coconut oil. For issue territories like feet and heels, slip on cotton socks in the wake of saturating. Likewise, saturating straightforwardly in the wake of showering while skin is still sodden can help secure dampness. There are other characteristic lotions that you may need to think about also. Olive oil cream is getting to be progressively mainstream, as is the utilization of additional virgin olive oil on its own for skin and hair saturating. Olive oil might be utilized in the wake of showering or as a hot oil medicine for dry hair. An alternate top part is shea margarine. Shea spread is determined from shea tree products of the soil prized for its humectant lands, which is the reason you'll discover shea margarine moisturizer, cream and different items.
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Date:
February 28, 2014 11:22 PM
Benefits of coconut lotion to skin There are other characteristic lotions that you may need to think about also. Olive oil cream is getting to be progressively mainstream, as is the utilization of additional virgin olive oil on its own for skin and hair saturating. Olive oil might be utilized in the wake of showering or as a hot oil medicine for dry hair. An alternate top part is shea margarine. Shea spread is determined from shea tree products of the soil prized for its humectant lands, which is the reason you'll discover shea margarine moisturizer, cream and different items.
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DLPA (DL-phenylalanine)
What is a Maca Root?
What is an anemia?
How to prevent anemia?
What is an antimonium tartaricum?
What is allium cepa?
Turbinado sugar is a sugar stick based, insignificantly refined sugar. It is medium tan in color and has substantial precious stones. It's Frequently mixed up for customary tan sugar due to its light tan shade, however it’s made in an alternative manner. Numerous individuals think as of it to be healthier than both white and tan sugars, since it is for the most part less transformed and refined. 
Vitamin E cream has been accustomed to bring ease for a long time for some diverse conditions and Vitamin E Cream soothe the skin. In a large portion of these cases, the patients have been content with vitamin E cream and what is accomplished for them. At one time, the cream was utilized just by dermatologists and plastic specialists. Regardless they utilize it today as a preoperative and post-agent medicine to counteract wounding and swelling, accelerate the mending and reduce the scarring. 
Types of depression
Mild or Gentle Depression
Effects low adrenal to body
Benefits of an elderberry
Vitamin A
Individuals who wish to tone their skin, purge their brain, and unwind their figures ought to do what antiquated marvels like Cleopatra and the Queen of Sheba did: they utilized the salts from the mineral-rich Sea in Israel, which are known for their therapeutic and corrective profits. 
Life is all about knocks and wounds, to deal with the more physical ones Arnica is somewhat known jewel that everybody ought to get acquainted with and have promptly accessible. For the most part utilized as a treatment or oil, in cream or gel structure, Arnica is a herb utilized across the board for medicinal and medical aid purposes going back from the 1500's. Despite the fact that there are numerous herbs and homeopathic cures accessible, Arnica is one that is not difficult to utilize, whose adequacy has been demonstrated more than once. 
One of the best lotions for all skin sorts, particularly dry, is coconut oil. It is determined from ready coconut meat and is utilized for cooking and as a grease, Frequently for the skin. There may even be a few profits from the ingestion of characteristic coconut oil. Assuming that you are searching for coconut oil salve, there are numerous spots to discover it. You may run into it on the racks of health sustenance or entire nourishment stores. There are numerous online retailers who offer high quality coconut oil. Likewise numerous tanning moisturizers are enhanced with coconut oil. For issue territories like feet and heels, slip on cotton socks in the wake of saturating. Likewise, saturating straightforwardly in the wake of showering while skin is still sodden can help secure dampness. 
