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  Messages 1-16 from 16 matching the search criteria.
Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine Darrell Miller 7/27/23
The Truth About Sugar: How It's Digested, Metabolized, and Why Too Much Can Be Dangerous Darrell Miller 6/25/22
Reduce Inflammation Through Diet: Foods to Eat and Avoid Darrell Miller 4/30/22
Industrially processed fructose is just as addictive as alcohol andeven morphine, concludes study VitaNet, LLC Staff 1/10/19
Eating too much processed sugar increases your risk of Alzheimer's VitaNet, LLC Staff 9/26/18
Can L-Carnosine Be Used As An Anti-Aging Vitamins? Darrell Miller 4/18/12
What Is L-Carnosine And What Does It Do? Darrell Miller 3/30/12
Taurine - Essential or Non-Essential Amino Acid - You Decide? Darrell Miller 2/17/11
Fat Controls our hunger centers in the brain! Darrell Miller 4/4/08
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP) Darrell Miller 8/2/05
Promilin Fenugreek Extract - Supports Healthy Blood Sugar Levels Darrell Miller 6/28/05
RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available Darrell Miller 6/24/05
VANADIUM W/CHROMIUM - Supports Healthy Blood Sugar Levels Darrell Miller 6/24/05
Kyolic Garlic - Aged Garlic Extract May Help Manage Diabetes Darrell Miller 6/9/05
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Darrell Miller 6/9/05
R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid Darrell Miller 6/4/05




Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine
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Date: July 27, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine

What if there existed a form of thiamine that was more bioavailable and physiologically active than the conventional form we all know about? Well, that form does exist, and it is called Benfotiamine. Benfotiamine has been gaining popularity lately, especially among people dealing with diabetes and other metabolic disorders. But what exactly is Benfotiamine, and what makes it different? Lets explore Benfotiamine, its bioavailability, and its physiological effects.

Thiamine, also known as Vitamin B1, is a nutrient that plays a crucial role in energy production, nerve function, and metabolism. It is a water-soluble vitamin, which means it dissolves in water and is not stored by the body. However, conventional forms of thiamine have a limited ability to cross cell membranes and are easily excreted out of the body, rendering it ineffective for some individuals. This is where Benfotiamine comes in; it is a modified form of Vitamin B1 that is fat-soluble, highly bioavailable, and because cells are wrapped in lipid fat this form of B1 is capable of crossing cell membranes with ease.

Since our cell membranes are composed of lipids, fat-soluble nutrients can easily penetrate the cell barrier and get into living cells where the vitamin is needed. Upon entering the bloodstream, benfotiamine is converted to thiamin pyrophosphate (TPP), the biologically active co-enzyme of thiamin, which is responsible for energy metabolism. By raising the blood levels of TPP, benfotiamine has been shown to support glucose metabolism, reduce oxidative stress and inflammation, and protect against the damage caused by high levels of advanced glycation end products (AGEs).

In addition to its bioavailability, benfotiamine has been shown to have several physiological effect on the body. One of the key enzymes that benfotiamine influences is transketolase, which is involved in the pentose phosphate pathway, a metabolic pathway that generates NADPH, a vital molecule that protects cells against oxidative stress. By stimulating transketolase, benfotiamine supports the diversion of excess glucose to the pentose phosphate pathway, thereby reducing the production of reactive oxygen species and increasing the production of NADPH.

Another significant benefit of benfotiamine is that it helps protect the nervous system. Chronic high blood glucose levels are known to cause oxidative stress and to damage the peripheral and central nervous systems. However, benfotiamine has been shown to help lower oxidative stress markers and reduce the risk of nerve damage. This can in turn help reduce pain, numbness, and tingling sensations associated with nerve damage, making it a promising adjunct therapy for people with diabetic neuropathy.

In Summary: benfotiamine is a modified and bioavailable form of thiamine that offers unique benefits compared to conventional forms of Vitamin B1. Its fat-solubility enables it to cross cell membranes, raise levels of thiamin pyrophosphate, stimulate the transketolase enzyme, and support proper glucose metabolism. Its notable effects on the nervous system make it an attractive therapeutic agent for people with diabetic neuropathy. If you're seeking an alternative and highly effective form of thiamine, benfotiamine is definitely worth considering. Give it a try today!

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The Truth About Sugar: How It's Digested, Metabolized, and Why Too Much Can Be Dangerous
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Date: June 25, 2022 10:13 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Truth About Sugar: How It's Digested, Metabolized, and Why Too Much Can Be Dangerous


We've all heard the saying "sugar is sweet, but it's not so sweet when it's in your blood." This is a very accurate statement. Sugar is digested into glucose and fructose. Glucose raises blood sugar levels, while fructose is metabolized by the liver into fat. If too much fructose is consumed, it can result in the development of nonalcoholic fatty liver disease. We will discuss how sugar is digested, metabolized, and why too much can be dangerous!

What is glycation and what does it do to the body?

Glycation is a process that occurs when glucose binds to proteins, lipids, or nucleic acids. This can damage tissues and lead to the formation of advanced glycation end products (AGEs). AGEs are toxic compounds that contribute to the development of chronic diseases, such as diabetes, atherosclerosis, and Alzheimer’s disease. The body has mechanisms to prevent glycation, but these become less effective with age. Additionally, certain lifestyle choices, such as smoking and a high-sugar diet, can increase the risk of glycation. Therefore, it is important to be aware of the risks and take steps to protect the body from this damaging process.

How does sugar cause glycation?

Sugar causes glycation in several ways. First, when sugar is present in the bloodstream, it can attach to proteins and lipids, forming new molecules called advanced glycation end products (AGEs). Once formed, AGEs can accumulate in tissues and cause damage. Second, sugar can also indirectly cause glycation by promoting inflammation. Inflammation triggers a release of immune system chemicals that can damage tissues. Third, sugar can also impair the body's ability to regenerate tissues. This is because glycation damages DNA, making it difficult for cells to divide and multiply properly. over time, this leads to a decrease in the body's ability to heal wounds and repair damaged tissues. As a result, sugar plays a significant role in the development of conditions such as diabetes and Alzheimer's disease.

How can you prevent glycation from happening?

There are several ways to help prevent glycation from occurring. First, it is important to control blood sugar levels by eating a healthy diet and maintaining a healthy weight. Exercise can also help to regulate blood sugar levels and prevent glycation. In addition, antioxidants may help to protect against glycation by scavenging sugar molecules before they can attach to other molecules. By taking these steps, you can help to prevent glycation and the age-related conditions that are associated with it.

Should we be worried about sugar intake?

Sugar is a complex topic, and there is still a lot of scientific research to be done in order to understand all of its implications. However, based on the current evidence, it seems that we should be at least somewhat concerned about our sugar intake. Numerous studies have linked sugar consumption to an increased risk of obesity, type 2 diabetes, heart disease, and certain types of cancer. And while sugar itself is not necessarily bad for you, the truth is that most of us consume far more sugar than we need. The average American consumes over 150 pounds of sugar every year, which is well above the recommended limit. So, while you don't need to eliminating sugar entirely from your diet, it is important to be aware of how much sugar you're consuming and to make sure that you're not overdoing it.

What are some healthy alternatives to sugar?

Sugar is a common ingredient in many processed foods, and it can be difficult to avoid. However, consuming too much sugar can lead to weight gain, cavities, and other health problems. Thankfully, there are a few healthy alternatives that can be used in place of sugar. Stevia is a popular choice, as it is derived from a plant, has no calories, and does not elevate blood sugar levels. Xylitol and erythritol are both sugar alcohols that have a lower calorie content than sugar and do not cause cavities. These substitutes can be found in most supermarkets, and they can help to make healthier choices when it comes to sweetening food and drink.

So, while you don't need to eliminating sugar entirely from your diet, it is important to be aware of how much sugar you're consuming and to make sure that you're not overdoing it. There are a few healthy alternatives that can be used in place of sugar. Stevia is a popular choice, as it is derived from a plant, has no calories, and does not elevate blood sugar levels. Xylitol and erythritol are both sugar alcohols that have a lower calorie content than sugar and do not cause cavities. Try a sugar alternative in your next recipe and see how it tastes! You might be surprised at how good it can be.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6413)


Reduce Inflammation Through Diet: Foods to Eat and Avoid
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Date: April 30, 2022 10:02 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Reduce Inflammation Through Diet: Foods to Eat and Avoid

Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that many people deal with on a daily basis. It can cause pain and discomfort in the body, and it can make everyday activities difficult to perform. Luckily, there are ways to reduce inflammation through diet. We will discuss the foods that you should eat and avoid if you want to reduce inflammation. We will also provide some helpful tips for getting started!

How can you reduce inflammation through diet?

There are many ways to reduce inflammation through diet, but perhaps the most important is cutting out processed foods and sugar. These foods contain inflammatory compounds known as advanced glycation end products (AGEs), which can aggravate existing inflammation or cause it to develop in the first place. In addition, studies have shown that eating a diet rich in vegetables and lean proteins can help to lower levels of inflammation throughout the body. Choosing whole grains, fruits, and healthy fats like olive oil is also a good way to support a body that is fighting against inflammation. In short, adopting a diet low in sugar and processed foods and high in fruits, vegetables, and lean protein can go a long way toward reducing inflammation both now and in the long term.

Supplements to take to reduce inflammation?

Inflammation is a natural and necessary part of our immune response, but if it becomes chronic or extreme, it can cause issues for our overall health. There are many different supplements that have been shown to be effective in reducing inflammation and promoting overall good health, including omega-3 fatty acids, Boswellia, pumpkin seeds, and turmeric. These nutrients work by interfering with the production of inflammatory hormones and enzymes, changing the chemical balance within our bodies and helping to reduce swelling and discomfort. Whether taken as a capsule or added to your diet through food sources like fish oil or ginger tea, these supplements can be an excellent way to boost your system's ability to fight inflammation. So if you're looking for ways to reduce inflammation and improve your overall well-being, consider adding these key nutrients to your daily routine.

The most effective anti-inflammatory supplements, Fish oil, Curcumin, and Boswellia!

While there are a number of different anti-inflammatory supplements on the market, some have proven to be more effective than others when it comes to reducing inflammation in the body. Perhaps the most commonly recommended supplement for this purpose is fish oil, which is rich in Omega-3 fatty acids, a type of polyunsaturated fat that has been shown to be especially effective in reducing inflammation. Another popular anti-inflammatory supplement is curcumin, which gives turmeric its signature yellow color and is thought to have antioxidant and anti-inflammatory properties. Additionally, another powerful anti-inflammatory agent is derived from the resin of Boswellia trees called Boswellia extract. All of these compounds have been shown to reduce inflammation in various scientific studies and can therefore be considered among the most effective anti- inflammatory supplements available today.

Tips for getting started on a anti-inflammatory diet?

When trying to get started on an anti-inflammatory diet, there are a few key strategies that can help make the process more successful. First, it is important to stock your pantry and fridge with plenty of healthy foods like fruits, vegetables, lean proteins, nuts, seeds, and reduce refined sugar intake as much as possible. These nutrient-dense foods are packed with essential vitamins and minerals that help to reduce inflammation and promote overall health.

Another key strategy to keep in mind when starting an anti-inflammatory diet is the use of supplements such as curcumin and CBD. These powerful compounds are believed to have anti-inflammatory effects in the body, helping to curb inflammation at its source vs. simply masking symptoms with painkillers or steroids. You can incorporate these supplements into your diet by taking them as pills or liquids or by incorporating them into your cooking through recipes like curried chicken or infused coconut oil tinctures.

The latest for calmness, relaxation, and to fight inflammation is CBD

CBD, or cannabidiol, has become increasingly popular in recent years as a natural solution for relieving stress, promoting relaxation, and managing inflammation in the body. Unlike THC, which is the psychoactive compound found in cannabis, CBD does not produce any high or altered state of consciousness. Instead, its many benefits are achieved through interactions with various receptors throughout the body, modulating mood and regulating pain response. As more and more people turn to CBD to achieve a sense of calm and well-being without depending on traditional pharmaceuticals, this powerful compound continues to gain widespread attention as a promising treatment option for everyday health issues. So if you're looking for a natural way to feel more mellow and at peace with yourself and your environment, consider giving CBD a try! With proven effects on everything from chronic pain management to improved sleep quality, this powerful all-natural remedy has something to offer everyone. Whether you're ready to give CBD a try for yourself or just curious about its many potential benefits, there's never been a better time than now to learn more about this exciting new approach to health and wellness.

Inflammation is one of the most common health concerns today, affecting people of all ages and backgrounds. While diet and lifestyle can be major contributing factors like white sugar, there are also a number of dietary supplements that can help to reduce inflammation in the body. Curcumin, fish oil, and CBD are some of the most popular supplements for managing inflammation. These substances work by targeting key pathways involved in inflammatory responses, helping to prevent or reduce swelling and pain. They can be taken on their own or combined with other anti-inflammatory compounds for maximum effectiveness. Ultimately, whether you are trying to manage chronic illness or simply boost your overall health, using supplements such as curcumin, fish oil, and cbd can be a great way to go about it. So if you're looking for more tools to manage inflammation in your diet, these are certainly worth trying out.

Whatever methods you choose, remember that making small changes over time will be much more effective than trying to overhaul your lifestyle all at once. With a little patience and persistence, you can start down the path toward better health today! Let dietary supplements assist you in your goal to reduce inflammation each day for a life time!

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Industrially processed fructose is just as addictive as alcohol andeven morphine, concludes study
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Date: January 10, 2019 04:26 PM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Industrially processed fructose is just as addictive as alcohol andeven morphine, concludes study





Did you know that over 50 pounds of fructose is consumed annually each year by the average individual? Many people are unaware that this fructose can lead to an addiction that is just as strong as alcoholism. In fact, the Journal of the American Dietetic Association specifically found that there are similar social and metabolic components when you compare alcoholism to someone with an addiction to fructose. This shows just how dangerous everyday exposure to the artificial additive can be.

Key Takeaways:

  • For sweet lovers who would not do without a sweet, it has been found that fructose that is industrially processed is as addictive and damaging as alcohol.
  • Fructose or fruit sugar is healthy when taken from fruits naturally but it becomes unhealthy when the fructose is industrially produced.
  • Fructose and glucose are sugars in the body but fructose is more damaging to the body because it can lead to glycation which causes tissue damage.

"Sweets are well-loved by millions of people across the world, with at least 50 pounds of processed fructose being consumed per year."

Read more: https://www.naturalnews.com/2018-12-21-industrially-processed-fructose-as-addictive-as-alcohol-morphine.html

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Eating too much processed sugar increases your risk of Alzheimer's
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Date: September 26, 2018 09:52 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Eating too much processed sugar increases your risk of Alzheimer's





Eating too much processed sugar increases your risk of Alzheimer's

According to recent research, people that consume a lot of processed sugars run a greater risk of developing Alzheimer's disease. What happens is the high sugar levels damage a major enzyme called macrophage migration inhibitory factor. Previous research has already shown that people with diabetes are more likely to develop this disease. However, the most recent research looked at brain samples of people with and without this disease and the process of glycation. It showed that glycation damages the essential enzyme which regulates insulin and the immune response.

Key Takeaways:

  • High sugar levels damage a major enzyme called macrophage migration inhibitory factor or MIF which regulates insulin and the immune system.
  • Recent research shows two brain samples with and with out Alzheimer's disease and the process of glycation with in the body.
  • The processed sugars showed to damage the enzyme MIF which therefore resulted in greater risk of having Alzheimer's disease.

"Research has found that a high intake of processed sugar can raise the risk of Alzheimer’s disease."

Read more: https://www.naturalnews.com/2018-09-12-eating-too-much-processed-sugar-increases-your-risk-of-alzheimers.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5773)


Can L-Carnosine Be Used As An Anti-Aging Vitamins?
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Date: April 18, 2012 07:31 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can L-Carnosine Be Used As An Anti-Aging Vitamins?

Carnosine And Your Health

Carnosine has gained widespread popularity as an anti-aging compound despite some skeptical voices in the scientific community. Many studies lend credence to its value for treating the signs of aging and its antioxidant properties are well researched. Carnosine is also widely used as a supplement to prevent complications from diabetes such as nerve and kidney damage. This article will discuss the details of what it is, what it seems to do in the body and how it may be able to help people restore a more youthful state of health.

Discovered in Russia more than a century ago, Carnosine is an amino acid and is found primarily in muscle, skeletal and nervous tissue (including the brain). As such the primary dietary sources are animal products such as fish, poultry and red meat. It is common for vegetarians to become deficient in it, making them ideal users of carnosine supplements.

Glycation

There is a gradual decline in carnosine levels as we age, which lends credence to the claims of its anti-aging properties. The most clearly established property of carnosine is its ability to act as an anti-glycation agent. Glycation is a process the body goes through to release energy from sugar but which ends up producing harmful substances. Carnosine can neutralize some of these already formed substances and also prevent the process from forming new ones. Some researchers believe glycation may be the key behind the benefits of caloric restriction, making carnosine the long awaited magic pill that can mimic its effect as a longevity treatment without the deprivation of restricting food intake.

Antioxidant Properties

In addition to carnosine's anti-glycation effect, it also has antioxidant properties. The oxidation process which the body goes through naturally produces the well known "free radicals" which slowly damage the cells and are thought to play an important role in the aging process. Carnosine can neutralize this protecting the cells. This also has a beneficial effect at keeping the telomeres from shortening, which is thought to be the main cause of the aging process. Telomeres are the buffers at the ends of DNA code that protect the code from being corrupted, so when the telomeres become shorter there is less protection and a greater chance of things going wrong. This makes carnosine's protective benefits of great importance in the fight against aging.

Carnosine Protects The Cells From Damage Like Radiation

Studies show that carnosine can protect the cells from radiation damage, which is particularly useful for cancer patients who have to undergo radiological treatment. It also promotes the healing of wounds and protects cell membranes. Some studies demonstrate that it can literaly repair old cells and make them younger. As it binds easily to toxic metals, turning them into powerful antioxidants, it is very effective at protecting the body from their harmful impact.

Some of the most promising uses of carnosine are for the treatment and prevention of Alzheimer, the signs of aging in the skin, cataract, nerve and kidney damage and heart disease. The recommendation for use as a supplement is 500 miligrams, though the body can deal safely with much larger doses. Give Carnosine a try today and experience the difference yourself.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2636)


What Is L-Carnosine And What Does It Do?
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Date: March 30, 2012 08:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is L-Carnosine And What Does It Do?

What Is L-Carnosine

L-Carnosine is basically a combination of 2 vital amino acids-L-histidine and beta-alanine. It is naturally present in the body, mainly in the muscle, and in many animals too. Carnosine can be broken down easily into the two amino acids, but it is good to know that these amino acids work much better when combined to form L-Carnosine. L-Carnosine has the remarkable ability to revitalize, that is, to make older cells younger and lengthen their life cycle. This compound is commercially available and is the only one that has the rare and distinctive ability to rejuvenate cells.

What does L-Carnosine do?

In simple language, L-carnosine is able to transform itself into so many compounds with each performing or enhancing a number of crucial body functions such as:

May bind to dangerous metal compounds to make them inactive.

Turning the resultant metal compound/carnosine into useful antioxidants which in turn can be anti-ulcer agents

Protecting and stabilizing cell membranes, keeping cells safe from dangerous free radicals

Protecting healthy cells from damage caused by radiation

Fighting allergies

Enhances blood flow to the brain

Acts like a neurotransmitter, helping messages move from one nerve to the other. This helps fight dementia, as in Alzheimer's disease and Parkinson's disease, and boost memory.

Blocks guanylate cyclase activation, an enzyme associated with cancer, migraine, asthma, and septic shock.

Special derivatives of carnosine can help get rid of the accumulation of sugar compounds and abnormal protein in the eye. A variety of these compounds may cause glaucoma, cataracts, and macular degeneration.

Carnosine works like a catalyst to boost the work of so many other compounds and nutrients.

Benefits of using L-carnosine

Although L-carnosine benefits haven't been extensively researched, according to initial studies it may help in:

Dealing with complications related to cataracts, diabetes, neuropathy, and kidney failure.

It may also help in slowing down aging in skin, minimizing wrinkles as well as breakdown of elasticity in skin.

It can help to prevent joint inflammation, atherosclerosis, and formation of cataract.

Carnosine has been known to prevent and reduce cell damage occasioned by beta amyloid-the substance found in Alzheimer's patent's brain.

Additionally, carnosine appears able to help get rid of the helicobacter pylori bacterium, the organism associated with stomach cancer and peptic cancer. Therefore, it can significantly help protect and heal both peptic and gastric ulcers.

Other possible L-carnosine benefits

Increase muscle endurance and strength

Improves heart function

Speeds healing of wound

A powerful antioxidant that can deal with even the worst free radicals

Reduces inflammation and boosts immunity

It helps pull out or chelate some heavy metals from your body

May help autistic children

Act as anti-cancer agent in the body

Stabilizes cell membranes and slows down lipid peroxidation to protect the process of aging of the brain

L-carnosine can help in preventing or even treating age-related conditions like:

Cell aging/cellular senescence

Neurological degeneration

Cross-linking of eye lens

Build up of damaged proteins

Brain circulatory deficit

Muscle atrophy

Cross-linking of collagen in the skin

DNA chromosome damage

LDL cholesterol oxidation

Formation of AGEs i.e. advanced glycation end-products.

What is stopping you from taking L-Carnosine today?

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2623)


Taurine - Essential or Non-Essential Amino Acid - You Decide?
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Date: February 17, 2011 10:56 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Taurine - Essential or Non-Essential Amino Acid - You Decide?

Amino Acid Taurine Is Essential For More Than You Think

Taurine is an organic compound with acidic properties, which is synthesized in the pancreas in adults, but an essential amino acid in infants. Many neutraceutical products for infants are fortified with taurine, inasmuch as some newborns do not have the enzymes required to synthesize taurine. Taurine deficiency in adults results from deficiencies in other organic compounds, notably methionine and cysteine, which are its immediate precursors within the body.

Helps in Brain Development

It has long been postulated that taurine plays an important role in the human brain, especially in infants, protecting the nerve cells from possible neonatal damages. Taurine continues to affect the nervous system as we age, acting on gamma-aminobutyric acid, or GABA, and consequently enhances inhibitory synaptic transmissions. In addition, taurine is alleged to stimulate continuous activation of synapses characteristic of long-term potentiation, which memory and learning ability stem from.

Stabilizes Glucose Levels

Taurine is a powerful inhibitor of glycation, a process by which sugar molecules attach themselves to other biomolecules without the aid of enzymes, and thus subsequently impair the functions of these biomolecules. This process may take place inside or outside the body, but the substances that result from this process, which are referred to as advanced glycation end-products or AGEs, contribute to the formation of a number of major disorders in later life such as cardiovascular diseases, Alzheimer’s disease, age-related deafness and blindness, and cancer. Taurine keeps the cells from taking up AGEs from the blood, which is slowly excreted in the urine.

Regulates Adipose Tissues

It has also been observed that dietary taurine influences the metabolic pathways that give rise to the formation of adipose tissues, the fat reserves of the human body. These fat depot appear anywhere in the body, but are commonly tied to the subcutaneous fats, those that we see on the belly, chest, arms, and thighs. Moreover, body fat percentage has been an indicator of obesity, which is central to the use of taurine in regulating adipose tissues.

Influences Lipid Absorption

Taurine is a major component of bile, the fluid produced by the liver, stored in the gallbladder, and secreted in the small intestines to aid in the digestion of triglycerides, cholesterol, and other lipids. Also, several studies point to the effect of taurine on the binding of proteins to lipids to form lipoproteins, compounds that have been notoriously labeled as bad cholesterol. Not surprisingly, taurine has been suggested to maintain healthy levels of blood cholesterol and prevent cardiovascular diseases.

Fights Oxidative Stress

Sodas have become a part of our daily diet today, but little did we know that they are risk factors for oxidative stress, the continued peroxidation of cellular structures. Fructose in sodas and other sweetened beverages is the most dangerous of all sugars, inasmuch as it releases by-products called AGEs, which are highly reactive to oxidation. AGEs do not get excreted right away and are instead absorbed by cells, leading to irreversible damages to neuronal and vascular tissues in later life. Intake of taurine removes this problem.

Have you had your Taurine Today?

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Fat Controls our hunger centers in the brain!
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Date: April 04, 2008 11:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fat Controls our hunger centers in the brain!

The main cause of any chronic disease of aging including Type II diabetes, CV disease, obesity, osteoporosis, and cancer are all caused by miss communication between signals that tell your body how to turn energy into life and the brain. The two most important signals that we know of today are given by the hormones insulin and leptin.

Leptin is an extremely powerful and influential hormone that is produced by fat cells. It has totally changed the way scientific researchers look at fat, nutrition, and metabolism in general. Before leptin’s discovery in 1994, fat was regarded as strictly an ugly energy store that most everyone was trying to get rid of. However, after it was discovered that leptin is actually produced by fat, fat became an endocrine organ similar to the ovaries, pancreas, and pituitary, as it influences the rest of the body, especially the brain.

Leptin is the most powerful regulator known to date of eating and reproduction. Your fat tells your brain whether you should be hungry or eat and make more fat, whether you should reproduce and make babies, or whether to maintain and repair yourself. It can then be stated that instead of your brain being in control of your body, your body, especially its fat and leptin, controls your brain.

Throughout history, it has been in ones best interest to store some fat to call upon during times of famine. However, it is also just as bad to be too fat. For most of our history, it was necessary to run, hunt, and avoid being prey. Therefore, fat storage had to be highly regulated and it still is. When a person typically tries to lose weight, the body tries to gain it back, resulting in what is commonly known as yo-yo dieting. Because of this, it has long been theorized that there is a “set point” and there must be a hormone that determines this.

Science now believes that leptin is that hormone. So in order to break the yo-yo cycle, one must control leptin. If a person is getting too fat, the extra fat produces more leptin that is suppose to tell the brain there is too much fat stored and the excess should be burned. Signals are then sent to the hypothalamus to stop being hungry, stop eating, stop storing fat, and start burning off some extra fat. Controlling hunger is a major way that leptin controls energy storage. Hunger is a very powerful drive that will make you do all you can to eat if it is stimulated long enough.

The only way to eat less in the long-term is to not be hungry and the only way to do this is to control the hormones that regulate hunger. The primary hormone that does this is leptin. It has recently been found that leptin not only changes brain chemistry, but can also rewire the neurons in areas of the brain that control hunger and metabolism to do its bidding. The inability of the body to hear leptin’s signals plays significant and even primary roles in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, cancer, and even the rate of aging itself.

In a process called glycation, glucose reacts with protein which results in sticky, sugar-damaged proteins called advanced glycated end products, or AGEs for short. When protein is damaged, it can’t function or communicate properly. AGEs promote excessive inflammation and free radical damage. AGEs and free radicals from oxidation are two of the major molecular mechanisms that cause damage which leads to aging. AGEs cause skin and the lining of arteries to wrinkle and inflame, which contributes to plaque and heart attacks. They can also promote the formation of cataracts and macular degeneration leading eventually to blindness.

The glycation process has also been connected with the destruction of proteins and nerve cells that may lead to Alzheimer’s disease, memory loss, and a variety of neuropathies. Glycation and oxidation are two of the major molecular mechanisms where damage accrues, disease occurs, and death results. High blood sugar can suppress your immune system, making you more vulnerable to infection and cancer. Highly aggressive cancers outpace the availability of oxygen and therefore must use an anaerobic fuel, in the form of glucose. By consuming glucose (sugar), we feed cancer. Lastly, high blood levels of sugar form non-fiber carbohydrates and excess protein send leptin and insulin levels upward.

If there is a known marker for long life, it is low insulin levels. Insulin’s purpose is not only to regulate blood sugar, but to store excess energy for future times of need. Insulin also lowers blood glucose levels as a side effect from storing it away, not regulating it. Today, high glucose is quite normal, as our insulin levels are typically much higher than they were among our ancestors. When you are constantly bombarding your cells with insulin, they become insulin resistant. This causes insulin levels to rise, creating a hormonal derangement that has a catastrophic effect on the metabolism.

High insulin contributes to making you fat because it tells your cells to store nutrients as fat rather than to burn it. Repeated high levels of insulin cause insulin resistance. The more fat the body accumulates the more leptin the body can produce so fat works against to slow down insulin production causing insulin resistance..

High insulin causes the retention of sodium, fluid retention, excretion of magnesium, elevated blood pressure, cognitive heart failure, blood clotting, and arterial plaque formation. Heart attacks are much more likely to happen after a meal that is high in carbohydrates than after one that is high in fat. This triggers a stress response which can cause arterial spasm, constriction of arteries, elevated blood pressure, irregular heartbeat and sudden death. Insulin resistance along with low magnesium keeps you from metabolizing important fatty acids that are vital to your heart health in general.

As critical as insulin is in your health, leptin may even be more so. Leptin plays a significant role in obesity, heart disease, osteoporosis, autoimmune diseases, inflammatory diseases, and cancer. But there are clues as to how to live a long and healthy life which brings us back to fat and leptin and our need to control it. One can control their insulin production and fat by dietary changes and blood sugar supplements.



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Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)
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Date: August 02, 2005 03:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)

Benefits

Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.4

Thiamine and its Co-enzyme, TPP

Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.

Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites.

As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent.5 In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves.

Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose.6 To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.6

Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs).

AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food.7 At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated.8 It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs.9 Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin.10 Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter.

Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage.11

Safety

Benfotiamine has an excellent tolerability profile and can be taken for long periods without adverse effects.3,12 The statements in this fact sheet have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Scientific References

1. Bitsch R, Wolf M, Möller J. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab 1991;35(2):292-6.

2. Schreeb KH, Freudenthaler S, Vormfelde SV, et al. Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. Eur J Clin Pharmacol 1997; 52(4):319-20.

3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther 1996;34(2):47-50.

4. Frank T, Bitsch R, Maiwald J, Stein G. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. Eur J Clin Pharmacol. 2000;56(3):251-7.

5. Pike RL, Brown ML. Nutrition, An Integrated Approach, 3rd Ed. New York:MacMillan; 1986:467.

6. Hammes H-P, Du X, Edlestein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic neuropathy. Nat Med 2003;9(3):294-99.

7. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci 1984;81(2):583-7.

8. Brownlee M. The pathological implications of protein glycation. Clin Invest Med 1995;18(4):275-81.

9. Pomero F, Molinar Min A, La Selva M, et al. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol 2001;38(3):135-8.

10. Stracke H, Hammes HP, Werkman D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 2001;109(6):300-6.

11. Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 2003;52(8):2110-20.

12. Bergfeld R, MatsumaraT, Du X, Brownlee M. Benfotiamin prevents the consequences of hyperglycemia induced mitochondrial overproduction of reactive oxygen specifies and experimental diabetic neuropathy (Abstract) Diabetologia 2001; 44(Suppl1):A39.



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Promilin Fenugreek Extract - Supports Healthy Blood Sugar Levels
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Date: June 28, 2005 10:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Promilin Fenugreek Extract - Supports Healthy Blood Sugar Levels

  • Supports Healthy Blood Sugar Levels
  • Sports Nutrition and Blood Sugar
  • Benefits of PROMILIN

  • .. Your body’s ability to manage blood sugar may well be the single most crucial factor affecting your health and longevity, and the one most affected by diet and lifestyle. But today’s high-glycemic carbs and sugar-laden foods — combined with lack of exercise — are creating a serious challenge to your body’s intricate glucose/insulin regulatory system. The resulting cellular stress and deterioration have serious repercussions for both your mind and body. To promote optimal wellness through healthy sugar metabolism, Source Naturals formulated PROMILIN™ FENUGREEK EXTRACT, a potent extract from the highly valued herb fenugreek, into an advanced nutritional supplement designed to assist insulin production and support healthy glucose levels. As a complement to your diet, Source Naturals PROMILIN™ FENUGREEK EXTRACT is an excellent strategy to improve blood sugar levels, and consequently, quality of life.

    The basis of Source Naturals PROMILIN™ FENUGREEK EXTRACT is fenugreek (Trigonella foenum-graecum), a respected culinary and medicinal herb used throughout history. One of the formula’s fenugreek extracts is rich in galactomannan, a mucilaginous fiber that may benefit the bowel. The other extract is Promilin, a patent-pending complex of bioactive amino acids standardized to contain 20% 4-hydroxyisoleucine. This extraordinary amino acid derivative assists the pancreas in production of insulin. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing post-meal glucose levels — with little or no increase in blood insulin concentrations — a clear indicator of improved insulin sensitivity.

    Sports Nutrition and Blood Sugar

    Athletic energy and endurance depend on the ability of muscles to recover from exercise. Because PROMILIN promotes utilization of glucose and insulin by the the body’s muscle cells, “weekend warriors” will feel less fatigue on Monday morning. In a clinical study, PROMILIN increased glycogen re-synthesis by 63% over carbohydrate alone. This is the rate at which post-exercise muscle glycogen (energy) is restored. PROMILIN may also play a role in weight management because it helps your body metabolize carbohydrates more efficiently. And the less time glucose spends in your bloodstream, the less chance it will be converted into fat. By supporting glucose metabolism, Source Naturals PROMILIN™ FENUGREEK EXTRACT may help protect against a harmful process called glycation, where excess glucose reacts with amino acids to form crosslinked sugardamaged proteins that damage the linings of blood vessels, the lens of the eye, and the myelin sheath that insulates brain cells.

    Benefits of PROMILIN

  • • Promotes healthy blood sugar metabolism.
  • • Enhances natural metabolic sensitivity in healthy people.
  • •May assist in the transport of glucose to skeletal muscle.
  • • Promotes lean-muscle mass and aids anabolic recovery.
  • • Reduces body fat potential. Taking personal responsibility for your health and exploring safe natural alternatives to support prevention is the basis for the current revolution in health care. PROMILIN is a simple yet profound strategy for the increasingly recognized importance of maintaining proper blood sugar levels. Health food outlets are the center of this wellness revolution because only here can Source Naturals PROMILIN™ FENUGREEK EXTRACT and hundreds of other powerful natural compounds be found.

    References
    Madar Z., Abel R., Samish S., Arad J., 1988. Glucose-lowering effect of fenugreek in noninsulin dependent diabetics. European J of Clinical Nutrition Jan 42 (1): 51-4. Sauvaire Y., Petit P., Broca C., Manteghetti M., Baissac Y., Fernandez, Alvarez J., Gross R., Roye M., Leconte A., Gomis R., Ribes G., 1998. 4- Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion Diabetes Feb;47(2):206-10. Sharma RD., Ragtura TC., Rao NS., 1990. Effect of fenugreek seeds on blood glucose in type I diabetes; European J of Clinical Nutrition Apr 44 (4) 301-6.



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    RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available
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    Date: June 24, 2005 05:34 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available

    The average American’s life expectancy has risen dramatically over the last 100 years. Ideally those extra years will be quality ones. High levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help. Free radicals cause oxidative stress, which is a major cause of accelerated aging. Source Naturals presents the science of RENEWAL ANTIOXIDANTS. This Bio-Aligned Formula™ is a significant advancement over other products currently available. No other formula provides the broad range of high potency, established and newly discovered water and fat-soluble antioxidants that RENEWAL ANTIOXIDANTS delivers.

    Bio-Aligned Antioxidant Support

    RENEWAL ANTIOXIDANTS™ supports multiple body systems with a balanced spectrum of plantioxidants™ (botanical extracts with unparalleled ability to combat free radicals), vitamins and specialty nutrients that have powerful antioxidant properties. Research suggests dietary antioxidants help balance and modulate free radical activity and help maintain structure and function of important components of cells such as lipids, proteins, and DNA.

    Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to cells and tissues. Free radicals are unpaired electrons that can damage cells and compromise the function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of lipid and water soluble antioxidants to minimize this negative effect. No other antioxidant formula follows the science better than RENEWAL ANTIOXIDANTS to defend against the widest spectrum of destructive free radicals, including peroxyl, hydroxyl, and superoxide radicals, and singlet oxygen.

    Healthy Heart

    Antioxidants neutralize destructive free radicals and support cardiovascular health by halting the oxidation of cholesterol. Cholesterol is only harmful to us if it becomes oxidized. Oxidized cholesterol is an unstable molecule that damages arteries. RENEWAL ANTIOXIDANTS contains hearthealthy antioxidants including gamma E and tocotrienols, which are major lipid-soluble antioxidants that help maintain the integrity of cell membranes by preventing lipid oxidation. The formula includes hawthorn berry and grape seed, CoQ10, lycopene and other powerful antioxidants for heart support.

    Nourishing the Brain

    Antioxidants are critical for brain and nerve tissue because the brain is mostly composed of fats, which are very sensitive to free radical damage. Research has shown that stress can directly set in motion mechanisms that promote aging, which affects brain and nerve tissue. Ginkgo has been shown to increase memory performance and learning capacity as well as improve blood flow. It is also a free radical scavenger. RENEWAL ANTIOXIDANTS also contains DMAE, bilberry, CoQ10, grape seed, lipoic acid, vitamin B-2 and lutein for broad spectrum support.

    Liver Support

    Powerful antioxidants help minimize stress damage to liver cells and tissues, thereby supporting detoxification. N-acetyl cysteine is a powerful antioxidant. It is also a precursor to glutathione, a critical antioxidant and detoxifying substance produced in the liver. Silymarin is known for supporting the regeneration of the liver. Since the liver is prone to fat incursion, which makes it vulnerable to oxidative damage, the following fat soluble antioxidants provide critical protection: CoQ10, lipoic acid, ascorbyl palmitate, and gamma E.

    Immune Defense

    The immune system is unlike other body systems in that it is not a group of physical structures but a system of complex interactions involving many different organs. White blood cells generate enormous amounts of destructive free radicals in order to kill invading organisms. Vitamin C, a free radical scavenger, is concentrated in these white blood cells at a much higher level than in surrounding fluid. This extends their life and effectiveness by providing them with a built in defense mechanism against their own free radicals. RENEWAL ANTIOXIDANTS provides water and fat-soluble vitamin C (ascorbyl palmitate and ascorbic acid) along with vitamin A, beta carotene, CoQ10, lipoic acid, quercetin, selenium, gamma vitamin E, tocotrienols, zinc and turmeric, for added immune defense.

    Skin & Connective Tissue

    Skin is rich in lipids, proteins, and DNA, which are extremely sensitive to oxidation. Age-related changes due to oxidation, loss of elastic fibers and thickening of collagen fibers, cause skin to become fragile and less supple. A broad array of antioxidants protects skin and helps maintain its structure and tone. These include beta carotene, vitamin C, vitamin E, grape seed, zinc, amla (Phylanthus emblica), quercetin, DMAE, manganese and myricetin. Amla is a very effective herbal tonic. It is rich in polyphenols and vitamin C.

    Clear Vision

    Eye tissue is particularly prone to the effect of free radicals. Vision involves light being focused through the lens onto the retina. The macula, or center of the retina, receives the most light. However, sunlight is a powerful free radical generator. Lutein, a potent, fatsoluble antioxidant concentrated in the macula, helps maintain the integrity of the macula and the blood vessels that supply the macular region. The eye also has aqueous tissue that is better protected by water-soluble antioxidants, such as bilberry and grape seed. RENEWAL ANTIOXIDANTS provides these ingredients, along with lycopene, zeaxanthin, lipoic acid, vitamin A, beta carotene and ascorbyl palmitate to support healthy eyes.

    Energy Generation

    Mitochondria, the tiny energy factories within the cells, are the major source of free radicals produced by our own bodies. These components of cells produce ATP (the energy molecule) and provide energy for all cellular activity; therefore, antioxidants are crucial to keep the levels of oxidants they produce in check. RENEWAL ANTIOXIDANTS provides the antioxidant power of green tea, lipoic acid, zinc, vitamin B-2, CoQ10 and Mega H-, a source of electron rich hydrogen ions. Coenzyme Q10 is fat-soluble and its primary functions include activity as an antioxidant and as a cofactor in many metabolic pathways, particularly in the production of ATP in oxidative respiration.

    DNA Protection

    DNA, the blueprint for all molecules in the body, can be altered or damaged by oxidation. Protecting DNA is important for optimal health of all cells and tissues. According to invitro research, certain compounds, such as curcumin (from turmeric) and quercetin, can directly protect against strand-breakage and base oxidation. RENEWAL ANTIOXIDANTS contains these ingredients along with rosemary, pomegranate, raspberry, blueberry leaf, and carnosine. In in-vitro studies, L-carnosine reduced glycation, a process in which DNA and protein are damaged by glucose.

    Living Longer, Living Better Strategies for Wellness

  • • Eat Well: Include plenty of fresh fruits and vegetables. Antioxidants in foods exist as vitamins C and E, beta-carotene, selenium and as flavonoids (tea), lycopene (tomatoes) and anthocyanins (berries). The highest concentrations of antioxidants are found in deeply colored fruits and vegetables such as dark leafy greens, artichokes, blueberries, cranberries, plums, blackberries and cherries. Spicing up food with cinnamon, turmeric, cloves and oregano can also boost antioxidant power.
  • • Stay Active: Exercise benefits the heart, helps regulate weight and slows the aging process by increasing the amount of oxygen available to body tissues.
  • • Reduce Stress: Deep breathing improves your blood’s oxygenation and circulation.
  • • Stop Smoking: Smoking depletes the body of vitamins C and E along with other antioxidants.

    Wellness Revolution

    Taking personal responsibility for your health and exploring safe alternatives to support prevention is the basis for the wellness revolution. Your health food outlet is leading the way with education and quality products to help you take control of your well-being. Source Naturals is pleased to partner with these outlets to bring you the cutting edge nutritional science of RENEWAL ANTIOXIDANTS. Antioxidant protection is a fundamental part of the holistic healing system. Make this profound formula the cornerstone of your anti-aging program today.

    References

    Clement, M., Bourre, J. Graded dietary levels of RRR-y-tocopherol induce a marked increase in the concentrations of a- and y-tocopherol in nervous tissues, heart, liver, and muscle of vitamin E-deficient rats. Biochimica et Biophysica Acta 1334 (1991) 173-181. Borgstrom, L. Pharmacokinetics of N-acetylcysteine in Man. Eur J Clin Pharmacol (1986) 31:217-222. Hipkiss, A.R., et al. Carnosine, a protective, antiaging peptide? Int J Biochem & Cell Biol. 30, May 1998, 863-868.

    Heart and Blood Vessels Resveratrol, Gamma E, Tocotrienols, Vit C, Hawthorn Berry, Grapeseed, Myricetin, CoQ10, Ginkgo, Beta & Alpha Carotene, Zeaxanthin, Lycopene, Lutein, Astazanthin, Lipoic acid, Green Tea, Bilberry, Ginger, Turmeric, Blueberry Leaf

    Brain and Nervous System DMAE, Ginkgo, Carnosine, Bilberry, CoQ10, Grapeseed, Lipoic Acid, Vit B-2, Lutein

    Liver Lipoic Acid, N-Acetyl Cysteine, Vit A, B-2,and C, Beta Carotene, Silymarin, CoQ10, Selenium, Zinc, Gamma E, Tocotrienols, Turmeric, Ginger Glutathione, Wheat Sprouts

    Immune System Vit A & C, Beta Carotene, CoQ10, Lipoic Acid, Quercetin, Selenium, Gamma E, Tocotrienols, Zinc, Turmeric

    Skin & Connective Tissue Beta Carotene, Vit B-2, C & E, Grapeseed, Lutein, Lycopene, Zeaxanthin, Zinc, Amla, Quercetin, Manganese, DMAE

    Eyes and Vision Lutein, Beta Carotene, Vit A & C, Bilberry, Lycopene, Zeaxanthin, Lipoic Acid, Quercetin, Gamma E, N-Acetyl Cysteine, Selenium, Zinc

    Energy Production and Metabolism Green Tea, Ginger, Mega H-, Ginkgo, CoQ10, Lipoic Acid, Zinc, Vit B-2, Carnosine DNA Protection Turmeric, Quercetin, Rosemary, Grapeseed , Resveratrol, Lycopene, Lutein, Tocotrienols, GliSODin®, Carnosine, Zinc, Manganese, Amla, Pomegranate, Raspberry leaf, Blueberry leaf



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    VANADIUM W/CHROMIUM - Supports Healthy Blood Sugar Levels
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    Date: June 24, 2005 05:15 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: VANADIUM W/CHROMIUM - Supports Healthy Blood Sugar Levels

    Today’s sedentary lifestyles and sugar-rich, nutrient-poor foods are contributing to the rise of obesity in our society. The result: challenges to your body’s system of balancing blood sugar levels and insulin activity. Maintaining a healthy diet and lifestyle helps keep blood sugar levels in the normal range, but sometimes you need nutritional support when you don’t have time to make those healthy food choices. Source Naturals, the science company, introduces VANADIUMW/CHROMIUM for blood sugar support. Research shows that these two important minerals help maintain normal blood sugar levels when used as part of your diet.

    Vanadium works together with chromium to support healthy blood sugar levels. Research has shown that both of these important minerals play a key role in normal insulin function.

    Vanadium: Balances Insulin Activity Vanadium, named after Vanadis the Norse goddess of beauty, belongs to a group of biologically important metals known as transition elements. These metals have a natural tendency to form complexes with organic compounds called coordination compounds that serve important biological functions.

    Insulin is secreted by the pancreas in response to high blood glucose levels after meals. Without insulin, glucose cannot enter cells to provide fuel for cellular energy. The sugar that remains in the blood can create problems by binding with protein molecules, resulting in damaged, non-functioning structures, in a process called glycation. Some evidence suggests that vanadium supports these vital metabolic processes because of its ability to mimic the actions of insulin.

    More Absorbable Form of Vanadium

    Absorption of dietary vanadium and supplemental vanadium is poor. It is estimated that less than 5% of dietary vanadium is absorbed. Organic forms of vanadium, such as bis-glycinato oxovanadium or BGOV, are recognized as being more absorbable. BGOV is an organically bound, bioavailable form of vanadium complexed with the amino acid glycine. Glycine, an amino acid found in the protein of all life forms, generates superior vanadium absorption.

    Chromium: Supports Glucose Metabolism Chromium is a trace element the body needs in very small amounts, but it plays a significant role in human nutrition. Its most important function is to help regulate the amount of glucose in the blood. Insulin plays a role in this process, by regulating the movement of glucose out of the blood and into the cells. Chromium is a key constituent of the compound known as glucose tolerance factor (GTF). This mineral enhances the effectiveness of insulin, encouraging glucose to enter cells, where it can be burned for fuel.

    Chromium participates in glucose metabolism by enhancing the effects of insulin. Insulin binds to insulin receptors on the surface of cells, activating those receptors and stimulating glucose uptake by cells. Through its interaction with insulin receptors, insulin provides cells with glucose for energy and prevents blood glucose levels from becoming elevated. Glucose buildup in the bloodstream is associated with adverse changes in lipid profiles and increased challenges for cardiovascular health. Some studies examining the effects of chromium supplementation on lipid profiles have observed reduction in serum total cholesterol, LDL cholesterol, and triglyceride levels. Source Naturals VANADIUM W/CHROMIUM includes ChromeMate®, a patented compound of chromium and niacin with proven GTF activity.

    Wellness Nutrition

    Taking responsibility for your health is at the heart of the wellness revolution. Sometimes life may seem like it’s passing you by and you may not have time to focus on staying healthy. Your local health food outlet is a great resource for nutritional education and effective, advanced natural products. Source Naturals is pleased to partner with these outlets to bring you products like VANADIUM W/CHROMIUM to help you maintain a healthy balance.

    References:

    Anderson, R.1998. Chromium, glucose intolerance and diabetes. Journal of the American College of Nutrition 17(6):548-555. Jellin, J., et al. 2004. Vanadium Monograph. Pharmacists Letter/Prescribers Letter Natural Medicines Comprehensive Database. Therapeutic Research Facility. Nandhini, S., et al. 1993. Insulin-like effects of bis-glycinato oxovanadium complex on experimental diabetic rats. Indian Journal of Biochemistry and Biophysics 30:73-76.



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    Kyolic Garlic - Aged Garlic Extract May Help Manage Diabetes
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    Date: June 09, 2005 05:30 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Kyolic Garlic - Aged Garlic Extract May Help Manage Diabetes

    Aged Garlic Extract May Help Manage Diabetes Recent tests already show hope that aged garlic extract can prevent damage to eyes, kidneys, blood vessels and skin

    Can aged garlic extract really help diabetics preserve their vision? People who have diabetes often suffer from damage to their eyes, kidneys, blood vessels and skin. This is caused by high sugar levels in a process called glycation. Researchers at Manchester University in England have already shown that garlic, in liquid form, may be a potent block on glycation in the lab. Now the same researchers will study the effect of liquid Kyolic® Aged Garlic Extract in a clinical trial involving 70 patients with Type 2 diabetes, the most common form of diabetes.

    The researchers are looking at whether a natural product can help prevent diabetes or play a role in the treatment of the disease. "One of the other things that people with diabetes have is increased free radical activity which could have a role in these complications," said Dr. Nessar Ahmed, molecular biologist at the university's department of biological sciences. Aged garlic extract's antioxidant compounds fight free radicals which damage healthy cells, and have been widely studied.

    Aged garlic extract is produced by a long extraction process, up to two years, creating an odorless product rich in active, bioavailable compounds. This extract is standardized to ensure consistent levels and ratios of these unique compounds. In fact, some of these beneficial compounds are not found in regular raw garlic or other garlic supplements.

    More than 375 scientific studies have been completed on aged garlic extract, done in major universities and research centers. These studies have focused on various aspects of garlic's health benefits including the reduction of multiple risk factors such as cholesterol and high blood pressure lowering effects; homocysteine control; inhibition of LDL oxidation (reducing sticky cholesterol); blood-thinning effect; and stimulating blood circulation by widening blood vessels. In addition, other aged garlic extract research has concentrated on immune enhancement, improving memory (prevention of Alzheimer's), protecting liver function and anti-cancer effects.



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    The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
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    Date: June 09, 2005 05:22 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

    The Latest Breakthroughs in Garlic Research

    on Cancer and Cardiovascular Disease

    Presented at the 2005 World Garlic Symposium

    Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.

    “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”

    Presentation highlights included:

  • • Clinical Intervention Trial and pre-clinical substantiation on Cancer using Garlic, presented by National Cancer Institute scientists, Mitchell Gail and John Milner Mounting evidence points to the anticancer properties of aged garlic extract and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis.

  • • Inhibition of Coronary Arterial Plaque Accumulation by Garlic, presented by Matthew Budoff, Harbor-UCLA Medical Center

    Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.

  • • Influence of Garlic on Endothelial Dysfunction in Hyperhomocysteinemia, presented by Norbert Weiss, University of Munich in Germany Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute high homocysteine on endothelium-dependent brachial artery vasodilatation and on acetylcholine-induced stimulation of skin perfusion.

  • • Anti-glycation properties of aged garlic extract: possible role in prevention of diabetic complications, presented by Nessar Ahmed, Manchester Metropolitan University in England Aged garlic extract inhibited the formation of advanced glycation end products, which have been previously shown to increase the risk of diabetic complications ranging from heart disease to retinopathy, kidney failure, impaired wound healing and many more.

    “Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”

    Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .

    Abstracts

    PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892

    Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.

    INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA

    Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.

    INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany

    Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.

    Bibliographies

    David Heber, MD, PhD, FACP, FACN

    Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center

    Matthew Budoff, MD, FACC

    Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.



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    R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid
    TopPreviousNext

    Date: June 04, 2005 02:23 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid

    R-Lipoic Acid

    Lipoic acid may be the body’s most versatile nutrient. Its critical importance for health is scientifically documented. Not only is it a powerful antioxidant, it supports healthy sugar metabolism and liver function, and is integral to energy generation, which affects all biological functions. But few know that the commonly available form, alpha lipoic acid (ALA), is not the same compound that occurs naturally in our bodies. ALA is a 50/50 combination of natural form r-lipoic and synthetic s-lipoic acid—and the synthetic form may actually block the activity of r-lipoic acid, resulting in a weaker product. Because it is the natural form, r-lipoic acid is better absorbed and safely metabolized. And it is up to 10 times more effective at producing cellular energy, according to in vitro research, and may be a more potent antioxidant. Source Naturals, the science company, is proud to be one of the first to offer this breakthrough nutrient: R-LIPOIC ACID

    R-Lipoic Acid: Key to Cellular Energy Generation

    Plants capture solar energy in their carbohydrates. In a reverse process called oxidation, animals extract that energy. R-LIPOIC ACID is a vital link in the metabolic pathway that gives us the power to move and the energy of intelligence. R-LIPOIC ACID is synthesized in the mitochondria, the tiny power plants inside every cell that produce energy in the form of ATP. It is safely metabolized and up to 10 times more effective than other forms of lipoic acid in mitochondrial ATP production, according to an in vitro study.

    Supports Glucose Metabolism

    Human and animal studies show that R-LIPOIC ACID can increase glucose uptake by muscle and nerve cells. By enhancing sugar metabolism, R-LIPOIC ACID may protect cells from glycation. In this detrimental process, excess glucose reacts with proteins to create tough crosslinked bonds that damage vital proteins, including the myelin sheath of neurons and the lens of the eye. Scientists believe glycation is a major source of tissue degradation and cellular aging. Collagen, another important protein, is also subject to crosslinking, which inhibits the flexibility of blood vessel walls—one of the most important indicators of cardiovascular health.

    Increases Antioxidant Protection

    R-LIPOIC ACID also neutralizes the harmful byproducts of glucose metabolism, free radicals. The body synthesizes barely enough R-LIPOIC ACID for its metabolic needs, and this decreases with age. As mitochondrial energy production becomes less efficient, more free radicals are generated. R-LIPOIC ACID protects cells, particularly in the mitochondria, where most oxygen damage occurs. R-LIPOIC ACID is a leading component of the body’s antioxidant network. Unlike other antioxidants, it is water and fat-soluble, so it neutralizes a greater number and broader range of free radicals, providing more protection. In animal studies, R-LIPOIC ACID slowed the aging process, which may be the result of cumulative oxidative damage. Lipoic acid, known as the “universal antioxidant,” is a strong antioxidant in its own right, but it also directly recycles vitamin C and indirectly recycles vitamin E for continued use. And R-LIPOIC ACID is more efficient than other forms of lipoic acid at increasing levels of the key antioxidants, CoQ10 and glutathione. Commercial alpha-lipoic acid is 50% synthetic s-lipoic acid, which can interfere with natural form R-LIPOIC ACID when both forms compete for binding sites. Tests showed 40% better absorption by R-LIPOIC ACID, as measured by plasma concentration levels.

    Integral to Your Wellness Program

    Because it is central to such critical functions as energy generation, antioxidant protection, anti-glycation activity, and liver support, R-LIPOIC ACID belongs at the center of your wellness program. Source Naturals is happy to join forces with your natural foods retailer in bringing you this advanced nutrient.

    References:
    Bonaventura, C., et al. 1995. Biochem Pharmacol 50(5): 637-46. Breithaupt-Grogler K. et al. April 1999. Eur J Pharm Sci 8(1):57-65. Hagen, T., et al. 1999. The FASEB Journal 13(2):411-8. Loeffelhardt S. et al. 1996. Biochimica et Biophysica Acta 1297:90-98. Lykkesfeldt, J. et al. 1998. The FASEB Journal 12:1183-1189.



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