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Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?   
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and Glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592) Glutathione Supplementation Can Boost Your Antioxidant potential and more! 
Date:
October 27, 2022 10:47 AM
Glutathione is a small peptide molecule composed of three amino acids: cysteine, glutamic acid, and Glycine. It is produced by every cell of the body, with especially high levels in the liver.* Glutathione is critical for healthy immune system function and is necessary for proper detoxification processes.* It also plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E.* This product has glutathione in its reduced, active form for optimal bioavailability.* Glutathione has many benefits, which is why it is often referred to as the "master antioxidant."* It is involved in numerous biochemical reactions in the body, including DNA synthesis and repair, protein synthesis, enzyme activity, and cell signaling.* Glutathione also helps to Detoxify the body by binding to heavy metals and other toxins so that they can be excreted from the body.* In addition, glutathione has been shown to boost energy levels, improve mental clarity and focus, and even promote weight loss.* As you can see, there are many good reasons to make sure you are getting enough glutathione! How to Increase Your Glutathione Levels There are a few things you can do to make sure your glutathione levels stay high. First, eat a diet rich in sulfur-containing foods like garlic, onions, eggs, and cruciferous veggies. You can also supplement with N-acetylcysteine (NAC), which is a precursor to glutathione. Taking methylated B vitamins will also help because they are needed for glutathione production. Finally, make sure you are getting enough vitamin C since it is necessary for glutathione recycling. One of the best ways to increase your glutathione levels is to supplement with Glutathione. This product provides 500 mg of pure reduced L-glutathione per capsule. It is GMO free, vegan friendly, and does not contain any artificial colors or flavors. Glutathione is a pharmaceutical grade product that is manufactured in an FDA-inspected facility in accordance with Good Manufacturing Practices (GMP). With Glutathione, you can be sure you are getting a high quality product that will help you maintain optimal health! As you can see, there are many good reasons to make sure you are getting enough glutathione. If you want to maintain optimal health, consider supplementing with Glutathione. With 500 mg of pure reduced L-glutathione per capsule, it is one of the most potent products on the market. You can be sure you are getting a high quality product that will help you maintain optimal health! Order your bottle today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6536) Glutathione: The Most Important Molecule You've Never Heard Of
Date:
October 22, 2022 10:17 AM
Glutathione is a small peptide molecule composed of three amino acids: cysteine, glutamic acid, and Glycine. It is produced by every cell of the body, with especially high levels in the liver.* Glutathione is critical for healthy immune system function and is necessary for proper detoxification processes.* It also plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E.* Milk thistle extract and alpha lipoic acid are included as complementary ingredients. What does that mean for your health? In short, glutathione is one of the most important molecules for your overall health and wellness. Read on to learn more about this incredible molecule and how you can make sure you're getting enough of it. Why You Need Glutathione Your immune system is your first line of defense against illness and disease. Glutathione plays a critical role in immune system function, so making sure you have enough of it is crucial to maintaining your health. Glutathione is also necessary for proper detoxification processes. It helps your body eliminate toxins and other harmful substances. In addition, glutathione plays an important role in cellular health. It directly neutralizes free radicals, which can damage cells and lead to chronic diseases like cancer. Glutathione also helps keep vitamins C and E active, which are both important for cellular health. Milk thistle extract and alpha lipoic acid are included as complementary ingredients to help support glutathione production. Getting Enough Glutathione You can get glutathione from certain foods, such as broccoli, cabbage, spinach, and garlic.* However, the best way to ensure you're getting enough glutathione is to take a supplement. supplements are the most bioavailable form of glutathione, which means they're better absorbed by the body.* Look for a supplement that contains all three amino acids (cysteine, glutamic acid, Glycine) in a 2:1:1 ratio. You should also make sure that the supplement you choose includes milk thistle extract and alpha lipoic acid as complementary ingredients. In Summary: Glutathione is a small but mighty molecule that plays a pivotal role in overall health and wellness. If you're not already taking a glutathione supplement, now is the time to start! Look for a supplement that contains all three amino acids in a 2:1:1 ratio, as well as milk thistle extract and alpha lipoic acid. Your body will thank you for it!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6517) Betaine aka TMGs Many Benefits as a Methyl Donor
Date:
October 21, 2022 12:29 PM
Methylation is a process in the body that helps to produce DNA, keep hormones in balance, and support detoxification. You need methyl groups for this process to happen, and TMG (trimethylGlycine) donates methyl groups to help with methylation. TMG also supports cardiovascular health and cognitive function while reducing inflammation. Not sure if TMG is right for you? Keep reading to learn more about this methyl donor’s benefits. Benefit #1: TMG Promotes Healthy Methylation As we just touched on, one of the main benefits of TMG is that it promotes healthy methylation. As we know, methylation is important for DNA production, hormone balance, and detoxification support. TMG provides the extra push of methyl groups needed to keep these processes running smoothly which is why it’s often taken as a supplement. If you have difficulty methylating or you have a genetic mutation that affects methylation, TMG may be a good supplement for you to consider. Check with your doctor first, of course! Benefit #2: TMG Supports Cardiovascular Health TMG also known as betaine, can improve cardiovascular health by reducing homocysteine levels. Homocysteine is an amino acid that at high levels has been linked to heart disease. While more research needs to be done in this area, initial studies are promising. In one study of nearly 500 participants, researchers found that those who took TMG had lower levels of homocysteine than those who didn’t supplement with the nutrient [1]. While this doesn’t prove causation, it’s an interesting correlation worth noting—especially given that other studies have found similar results [2]. benefit #3: May Reduce Inflammation Chronic inflammation has been linked to many diseases such as heart disease, arthritis, and even cancer. Some studies suggest that TMG may help reduce inflammation levels in the body [3]. In one animal study, rats given TMG had reduced lung inflammation compared to rats who weren’t given the supplement [4]. More research needs to be done in this area but initial studies are promising. In Summary: TMG is a nutrient known as a methyl donor which means it provides methyl groups needed for processes like DNA production and hormone balance. It also supports cardiovascular health and cognitive function while reducing inflammation. If you have difficulty methylating or you have a genetic mutation that affects methylation, TMG may be a good supplement for you to consider. Check with your doctor first!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6514) Everything You Need to Know About DMG (Dimethylglycine)
Date:
October 11, 2022 10:24 AM
DMG (DimethylGlycine) is a derivative of the amino acid Glycine that can be found in foods such as beans, brown rice and pumpkin seeds. DMG is an important methyl donor that participates in numerous biochemical pathways and is important for glutathione synthesis.* It also helps to promote optimal cellular oxygen utilization and supports the production of cells involved in the immune response.* While you may not have heard of DMG before, this compound plays an important role in keeping your body healthy. Read on to learn everything you need to know about DMG. What is DMG? DMG is a small molecule that donates methyl groups (CH3). Methylation is a process that occurs throughout the body and is essential for many biochemical reactions, including the production of DNA, enzymes, hormones and neurotransmitters. DMG is involved in methylation reactions involving homocysteine, folate, cobalamin (vitamin B12) and NADH.* DMG also supports glutathione synthesis, which is important because glutathione is a key antioxidant that protects cells from damage caused by free radicals.* Furthermore, DMG promotes optimal cellular oxygen utilization and supports the production of cells involved in the immune response.* Health Benefits of DMG Because of its involvement in so many biochemical pathways, DMG has a wide variety of potential health benefits. Some of the most well-researched benefits include support for cardiovascular health, brain function and exercise performance. Cardiovascular Health: DMG has been shown to support cardiovascular health by reducing blood pressure and improving blood flow.* It does this by dilating blood vessels and reducing inflammation.* Brain Function: DMG has also been shown to support brain function, particularly in aging adults. One study found that supplementing with DMG improved mental clarity, memory and cognitive function in seniors.* The compound may also help improve focus and concentration. Exercise Performance: Finally, DMG has been shown to improve exercise performance. One study found that athletes who supplemented with DimethylGlycine had increased VO2 max – a measure of cardiovascular fitness – compared to those who didn’t supplement.* Furthermore, another study found that cyclists who supplemented with DMG had reduced heart rate and perceived exertion during exercise.* This suggests that dimethylGlycine may help improve endurance exercise performance. In Summary: DMG (DimethylGlycine) is a derivative of the amino acid Glycine that can be found in foods such as beans, brown rice and pumpkin seeds. This compound plays an important role in numerous biochemical reactions in the body and has a wide variety of potential health benefits. Supplementing with DMG 100-500 mg per day is generally well tolerated with few side effects reported. If you do experience any adverse effects when taking DMG ramp up your dosage slowly to give your body time to adjust.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6498) N Acetyl Cysteine: A Decades-Old Remedy With Many Uses
Date:
April 27, 2022 11:53 AM
Did you know that N Acetyl Cysteine has been around for decades? This powerful supplement was first discovered in the 1950s and has been used as a remedy for many health issues since then. We will discuss the many benefits of N Acetyl Cysteine and how you can start using it to improve your health! Glutathione and aging As we age, our natural levels of glutathione tend to decline. This is a major cause of many of the negative effects associated with the aging process, including reduced energy and slower recovery times after illness or injury. Fortunately, there are steps that we can take to increase our levels of glutathione, thus slowing down the aging process and keeping us feeling young and vibrant for longer. Some of these steps include eating a healthy diet rich in antioxidant-rich foods like fruits and vegetables, engaging in regular physical activity to improve circulation, and reducing stress levels through relaxation techniques like yoga and meditation. With these strategies in place, we can help to keep our bodies strong, boost our energy levels, and stay young well into old age. Fortunately, there is a supplement that could help, it is called N Acetyl Cysteine, this substance is a precursor to Glutathione and has been shown to boost glutathione levels. What is N Acetyl Cysteine and what are its benefits? N acetyl cysteine has been used as a supplement for many years, and its popularity is likely due to the many benefits it offers. The main function of this compound is to promote the production of glutathione, a powerful antioxidant that protects our bodies from oxidative stress and harmful free radicals. In addition, n acetyl cysteine has been shown to help reduce symptoms of certain mental health disorders, including anxiety and depression. Furthermore, studies have found that n acetyl cysteine may lower blood pressure and improve heart health by increasing blood flow and improving blood vessel function. Overall, it is clear that n acetyl cysteine has been an effective nutrient for many years and continues to be widely used by those looking for an easy way to support their health. How can you start using N Acetyl Cysteine to improve your health? N acetyl cysteine (NAC) is a powerful antioxidant that can help to protect cells from damage. It has been shown to be particularly effective in guarding against liver damage, and is often used as a treatment for hepatitis C. NAC can also help to improve lung function and relieve respiratory conditions such as bronchitis and asthma. In addition, NAC has been shown to boost levels of glutathione, which is a key molecule involved in detoxification. As a result, NAC can help to cleanse the body of harmful toxins and pollutants. NAC is available in supplement form, and can be taken orally or intravenously. It is generally well tolerated, with mild side effects such as nausea and vomiting occasionally reported. When taking NAC supplements, it is important to start with a lower dose and increase gradually as tolerated. Those with pre-existing medical conditions should always speak to their doctor before taking any new supplement. Overall, NAC is a safe and effective way to improve your health and protect your cells from damage. What is the recommended daily dosage for N Acetyl Cysteine per day? The standard recommended dosage for N-acetyl cysteine (NAC) is 600 mg per day. However, some studies have used dosages as high as 2,400 mg per day. The most common side effect of NAC is nausea, which can be minimized by taking the supplement with food. NAC is also sometimes used as a treatment for chronic bronchitis, and the recommended dosage for this condition is 1,200 mg per day. When used for this purpose, NAC is typically taken in divided doses of 600 mg twice per day. There is currently no consensus on the optimal dosage of NAC for any particular condition, and further research is needed to determine the ideal dosage for different applications. In acute circumstances, one might need 4000mg to 6000mgs daily in divided dosages, always work your way up to higher dosages as needed. What are some of the most common uses for this supplement? There are many different uses for NAC, or N-acetyl cysteine. This potent antioxidant supplement has been found to be effective in addressing a wide range of health concerns, including asthma and COPD, chronic sinusitis, liver disease, and particularly serious conditions such as cancer. Additionally, NAC has been shown to provide support for the immune system in general and may also serve as a detoxifying agent by helping to eliminate waste products like heavy metals from the body. Overall, there are numerous benefits to using NAC as part of a well-balanced diet. Whether you are looking to improve your respiratory health or strengthen your immune system, this versatile supplement can help you achieve your goals. NAC composition NAC, or N-acetyl cysteine, is a complex compound that is composed of various amino acids, including glutamate, Glycine, and cysteine. These specific amino acids all play important roles in the function of NAC and affect its many beneficial properties. For example, glutamate increases metabolism and energy levels, while Glycine promotes tissue healing and regeneration. Cysteine, on the other hand, facilitates the transport of oxygen and serves as a natural antioxidant. When taken together, these different components work synergistically to promote overall health and wellbeing by supporting key physiological processes such as digestion and immune response. Whether taken as a supplement or consumed through food sources like eggs and milk products, NAC is a versatile substance that is vital to many aspects of our daily health and well-being. NAC and liver health N-Acetyl-Cysteine (NAC) is a compound that has numerous benefits for liver health. Studies have shown that NAC can help to protect the liver from damage caused by alcohol and other toxins. It does this by helping to replenish levels of glutathione, a key antioxidant that helps to detoxify the liver. NAC also helps to reduce inflammation and improve blood flow to the liver. As a result, it can be an effective treatment for both acute and chronic Liver diseases. In addition, NAC has been shown to improve the overall health of people with Liver cirrhosis. Consequently, N-Acetyl-Cysteine is a compound that has many benefits for liver health and should be considered as part of any comprehensive treatment plan. NAC, its sulfur content, and mucus elimination NAC, or N-acetyl cysteine, is a sulfur-containing amino acid that plays an important role in mucus production and elimination. The sulfur content of NAC helps to thin mucus and make it less sticky, making it easier to clear from the lungs. In addition, NAC helps to break down mucus and remove it from the body. As a result, NAC is often used as a supplement to treat respiratory conditions such as bronchitis and chronic obstructive pulmonary disease (COPD). NAC is typically taken in the form of capsules or tablets, and the recommended dose depends on the individual. However, side effects are rare and generally mild, making NAC a safe and effective option for those seeking to improve their respiratory health. N Acetyl Cysteine may lower blood pressure One of these is its ability to lower blood pressure. A review of several studies found that N-acetyl cysteine was effective at reducing blood pressure in people with hypertension. In one study, participants who took N-acetyl cysteine had an average reduction in systolic blood pressure of 9.5 mmHg, compared to those who took a placebo. Other studies have shown similar results, suggesting that N-acetyl cysteine may be an effective treatment for high blood pressure. While more research is needed to confirm these findings, N-acetyl cysteine may offer a safe and natural way to lower blood pressure. N Acetyl Cysteine may help blood clots - thrombosis Blood clots are a necessary part of the body's natural healing process. They help to stop bleeding by sealing off damaged blood vessels. However, sometimes blood clots can form in healthy blood vessels, causing a potentially deadly condition called thrombosis. N Acetyl Cysteine is a compound that helps to break up blood clots and prevent thrombosis. It works by preventing the formation of a protein that is essential for clotting. In addition, N Acetyl Cysteine helps to improve the flexibility of blood vessels, making them less likely to rupture. As a result, this compound may help to reduce the risk of thrombosis and improve overall cardiovascular health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6394) Powerful antioxidant helps us burn fat, lose weight and avoid premature aging
Date:
April 27, 2019 11:30 AM
Milk thistle is known for being good for the liver, but researchers are finding more and more evidence that points to an antioxidant called glutathione being a key component as well. The powerful antioxidant called glutathione allows our bodies to kick up their natural fat burning abilities which helps trigger weight loss in an almost effortless manner. Studies have also shown that a deficiency in glutathione can cause weight gain through a reduction in mitochondrial fat burning. Key Takeaways:
"Glutathione is synthesized from the amino acids cysteine, glycine and glutamate. But, as we age, two of these “building blocks” – cysteine and glycine – decline, causing shortfalls in glutathione production." Read more: https://www.naturalhealth365.com/antioxidant-lose-weight-2793.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6208) Health benefits of Gelatin
Date:
September 01, 2017 07:14 PM
Gelatin is more than just a snack; eating gelatin can provide some health benefits. Loss of collagen as a person ages causes skin to lose firmness, leading to lines and wrinkles. Gelatin, as a great source of collagen, may help keep skin looking smooth and youthful. One half cup serving of gelatin contains nearly 2 grams of protein, which the body needs. Gelatin may also aid digestion, both by providing glycine, which helps the mucosal lining in the stomach and by stimulating gastric juices. Read more: Health benefits of Gelatin
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5205) Chamomile: What You May Not Know!
Date:
September 16, 2016 09:52 AM
Chamomile is an excellent tea that everybody should have at their disposal when you need to relax and calm down from a busy stressful work day. The Tea is great tasting and easy to make.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3293) Adrenal Glandular Supplements
Date:
May 18, 2014 11:06 AM
Healthful supplements can help keep up the strength of your organs by guaranteeing legitimate working of the glandular framework. Like all organs, the organs need healthful backing. Particularly when anxiety exhausts the assemblage of put away supplements. Your organs produce and discharge substances into the body for the body’s utilization. A breakdown or an irregularity of any one glandular substance can make gigantic issues around the body. Organs has two classifications. The exocrine organs - open onto a surface of an organ; or other structure, through a pipe. Samples of the exocrine organs incorporate the salivary of the mouth and the sweat and oil organs of the skin. Other exocrine organs are found in the kidneys, the mammary organs and the digestive tract. The endocrine organs - are ductless, in this way emitting the substances they prepare (hormones) straightforwardly into the circulation system. By emitting hormones the endocrine organs help manage almost all substantial capacities. Samples of the endocrine organs incorporate the adrenal (on the kidney), the pancreas (behind the stomach), the pituitary organ (at the base of the mind), the pineal organ (connected to cerebrum), sex organs (testes/ovaries), the thymus organ (underneath the thyroid) and the thyroid and parathyroid organs (in the neck). Supplement source
Maintain a strategic distance from perk and soft drinks, which can dispose of vitality in your body and make you feel more tired. Furthermore, you ought to change your lifestyle. For instance, take a stab at dozing in until nine in the morning if at all conceivable and verify you practice and do exercises that minimize stress. Consume customarily and does something fun while staying far from contrary individuals and movements. Caution in taking the supplement In addition, you may want to take the fatigue supplements each day to help you recover from this glandular dysfunction and make you feel more energetic. If you have this syndrome, then there are supplements that you can take to help address the problem. Before taking any enhancers, contact your doctor and have him or her run a test first to see if you suffer from adrenal fatigue syndrome.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3121) Lavilin Deodorant reviews.
Date:
March 04, 2014 09:03 AM
Lavilin deodorant
Active ingredients.
Aluminium-some deodorants contains aluminium which causes breast cancer and Alzheimer. Most of the ingredients are from natural sources. This makes Lavilin a premier deodorants. It is also free from Parabens, though most anti-perspirants uses Parabens to improve shelf life, Lavilin uses natural methods. Parabens are very dangerous to our bodies since they can damage central nervous system, cause birth defects and endocrine disruption. It contains zero Propylene Glycol, Triclosan and Phthalates which are also very harmful to your health. It is also free from alcohol which damages skin pores and also causes blisters. Deodorants which contains alcohol will cause blisters and users will get irritation when they take bath. How it works. It works by eliminating bacteria that causes odor smell in your armpits. It does not prevent you from sweating, sweating is a very health process and any product that hinders normal body processes is definitely not good at all. Lavilin uses essential oils to eliminate bacteria and ensure your skin remains fresh and you have a good smell. Direction of use. This product should be used after taking shower. It has a good smell which will not work well if you have not taken bath. You can also use it after shaving, it does not cause irritations, it is very friendly. Upon it use, you will have fresh breath for more than 72 hours. It has a good smell and it will keep your skin fresh for more than 72 hours. It does not wear off easily even after taking a bath, it is promising product that will keep you confident for more than 4 days. Advantages. It is long lasting, upon wearing it, it will remain effective for more than 72 hours. You don’t need to use it daily. It is not affected by water, the scent will remain after taking bath. There is no strong smell, it scent is just friendly to you and other people. It is never shouty and only a person close to you will smell the scent. It does not stain clothes or make your armpits white. You clothes will not be discolored by use of Lavilin nor will your armpit get white color. You can use it after shaving, it does not cause blisters or irritations. It is very friendly. It is also very use, it has few and easy few to follow instructions. Shortfalls. Lavilin does not seem to be effective to men. It can last for more than 4 days when worn by a lady but for a man it will last for only three days. This call for regular use. Lavilin can be used by body builders or people taking strenuous exercise. It can also be used in nay weather, sunny, rainy or high humidity, it effectiveness is not lessened by weather condition. Sources
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3045) What Is Gelatin Powder Good For?
Date:
January 29, 2014 04:54 PM
What is Gelatin?
Health Benefits of Gelatin Powder Gelatin powder has many health benefits.It is a source of protein and dietary collagen. It is composed of two amino acids-proline and Glycine which many people do not consume adequately. This is because the amino acids are contained in organs of animals, fibrous tissue and in bones which a large population do not consume more often. These amino acids are important for proper hair, skin and nail growth. Gelatin powder helps in the recovery of joints when injured. Gelatin also provides building blocks for health joints. It has been noted that people with arthritis, joint pain and osteoporosis will see their situation improve when they take gelatine rich foods and supplements. It improves digestion as it binds to water making food move easily through the digestive truck. In this case the gelatine powder is usually used in form of a homemade bone broth. It supports hair, skin and nail growth. It will again protect your skin from wrinkles as your skin ages. Glycine which makes the large percentage in gelatine powder helps in speed wound healing and acts as an anti-inflammatory. It also improves sleep ease and quality. Believe it or not, it can also be used for weight loss. This is because it boosts metabolism when taken. Gelatin powder is used to naturally balance hormones in the body. High amounts of hormones like oestrogen in the body can cause infertility, inflammation and accelerate aging. Finally, gelatine is a cost-effective and nutritious way to get proteins in to your body. References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2992) Few reason that tell you why you should consume TMG regularly
Date:
January 11, 2014 05:20 PM
TMG or TrimethylGlycine
Benefits of TMG If we talk about benefits of TMG or TrimethylGlycine it is responsible for proper liver functioning, body detoxification, cellular replication, carinitine manufacturing, protection from diabetes and protection of kidney from any kind of damage. Other than this it can also help you to avoid a lot of genetic problems by regulating the genetic transcription process that is responsible for the creation of all the chemicals in body. In addition to this many researchers also believe it that TMG can improve the autonomous nervous system of body and if it is unbalanced, then it can help you to restore the system. Since TMG is responsible for cell duplication so if someone is facing problem of cell synthesis TMG can help those people as well in restoration of their regular body structure. In short we can say that TMG is one of the most important substances of human body that is very helpful for proper functioning of body in a very effective manner. Recommendation Therefore, it is recommended that if you are lacking for TMG you should take it as a dietary supplement so you can increase its count in your body and you can avoid these health problems and you can restore proper functioning of your body. However, it is also very important that you should take the TMG according to specific guideline suggested by your doctor and if you ever find any problem while consuming it, make sure you communicate your doctor about those problems.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2961) How chamomile works to relax you and help you sleep better
Date:
October 24, 2013 09:33 AM
What is chamomile
References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2855) The Role of Glycine in Collagen and Its Remarkable Health Benefits
Date:
March 17, 2013 08:41 AM
Collagen is basically made up of several amino acids and one of which is Glycine. This particular amino acid accounts 1/3 of the entire composition of collagen. It can be found in the third position in the sequence of the amino acids. One of the fundamental roles of this amino acid is that it reduces the water solubility of collagen by a hundred folds. Contrary to the fact that it's considered as a non-essential amino acid, Glycine has many health benefits aside from being a part of the collagen synthesis. The details below present some of the most essential information that you ought to know about this collagen component. Here they are: Glycine Synthesizes Normal DNA and RNA DNA and RNA are genetic materials necessary for the proper cellular formation and function. Glycine prevents the breakdown of the muscle tissues by increasing the body's creatine levels which is a compound that builds muscle mass. High concentration of this amino acid can also be found in the skin and connective tissues in the body and it keeps them flexible and firm. Without Glycine, the body won't be able to repair damaged tissues. Glycine Keeps the Central Nervous System Healthy Studies had shown that this amino acid is an inhibitor of the neurotransmitters that can cause seizures, hyperactivity and bipolar depression. As a matter of fact, it can be converted into serine which is a neurotransmitter beneficial in the treatment of schizophrenia. Researchers found out that schizophrenic patients exhibited significant improvements after adding Glycine with their anti-psychotic medication. It was also found out that it improves memory. Glycine Promotes Proper Function of the Digestive System This amino acid is known to induce bile acid production which is used to digest fats. It is also often included in most over-the-counter gastric antacid agents to prevent and treat acid reflux. Glycine Provides Glucose Specifically, this non-essential amino acid is also considered as glucogenic amino acid. That simply means that it provides glucose in the body. One of its benefits includes regulation of blood sugar levels, so it can be helpful in treating symptoms manifested by low energy and fatigue. Glycine May Help With Cancer Preliminary studies considered this amino acid as another breakthrough in cancer treatment. Results suggested that it can prevent the development of cancerous cells as it acts as an inhibitor of angiogenesis which is a process in which tumors, benign or malignant, develop their own blood supply. Sources of Glycine High-quality protein foods such as white meat from fish and chicken, beans, legumes, eggs and milk are known to be the main sources of this amino acid. Glycine supplements are also available in tablet or powder forms and can also be one of the components of many amino acid supplements. Except for some people complaining about having stomach upset and dizziness after taking Glycine supplements, there are no other noted adversarial or severe side effects of Glycine. If taken properly, such supplementation is extremely safe. Who Should Not Take Glycine? Those individuals suffering from kidney and liver diseases should never take Glycine. Pregnant women should never take as well. People taking antispatic medication are not allowed also since there could be interference between the drugs and Glycine. It's always best to consult a doctor first before taking such supplement. Those are all the most notable benefits of Glycine. The point here is that it is not just a mere part of a collagen but it also has a number of health benefits.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2831) What Are The Health Benefits Of Magnesium Glycinate?
Date:
March 12, 2013 11:58 AM
Magnesium Glycinate is derived from the attachment of magnesium to Glycine. The health benefits of Magnesium glycinate are many. Naturally, the body needs magnesium to function properly. If the magnesium levels in our blood are less than normal, it is necessary to take magnesium glycinate supplement. When the amount of magnesium in the human body is very low, it may lead to various ailments. Likewise, excessive intake of this nutrient may lead to fatigue, vomiting, nausea, diarrhea etc. Let us consider some of the health benefits of this supplement: Prevent High blood pressure Medical Experts believe that consuming a large amount of this supplement can help prevent or reduce the effect of high blood pressure. Individuals who are already suffering from high blood pressure can take this supplement to reduce hypertension. Increase Levels of HDL HDL stands for good cholesterol. This supplement can also help reduce levels of bad cholesterol and increase levels of good cholesterol. Improve Sleep Quality People who have low levels of magnesium may find it difficult to sleep. If you are yet to achieve a more restful sleep, perhaps you can take this supplement. Those who are struggling with restless leg syndrome may also find this supplement helpful. Mood enhancer Magnesium glycinate supplement can help balance your mood swings. According to the author of "Healing Depression Naturally" Lewis Harrison, magnesium has the ability to regulate neurotransmitter receptor sites. Harrison emphasizes on the use of magnesium glycinate as a good treatment for depression. He stated that magnesium glycinate helps to remove mercury from the body, which can lead to emotional stability. However, this claim is based on anecdotal evidence and not clinical studies. Notwithstanding, some persons have achieved success using this supplement to treat depression. Therefore, if you are struggling with fatigue, sleeplessness, depression, high blood pressure and high bad cholesterol levels, then this supplement is for you.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2829) Health Benefits Of Chamomile
Date:
December 03, 2012 07:56 AM
It is believed that ancient Egypt saw Chamomile as an effective cure for most illnesses. In the modern world too, this golden herb retains its healing properties and is used for treating many a disease and discomforts of the body. Most commonly, German chamomile blossoms are infused to prepare 'Chamomile tea' which is a fragrant concoction full of medicinal properties. The tea can be combined with honey to enhance the taste. Health Benefits Of Chamomile Tea Chamomile tea, supposedly, helps to bring about restful sleep. It is thus of great value for people suffering from insomnia and other sleep-related disorders. Due to its soothing and relaxing effects, it is generally taken before a person goes to bed. Since time immemorial, Chamomile has been considered a remedy for stomach ailments. Known to soothe gastric and bowel related problems, the herb is a blessing for people with stomach aches. All in all, Chamomile helps facilitate the complete digestion process by promoting bowel movement. For women facing menstrual cramps and nausea every month, Chamomile tea comes as a welcome relief. Research indicates that regular consumption of Chamomile tea increases the level of Glycine in the body. Glycine is a compound that controls muscular spasms, thus it tends to calm menstrual cramps. A healthy cup of golden chamomile tea has also been found to combat the morning sickness of pregnancy. However nothing has been proven till now to this effect. Some studies suggest that this wonder herb accelerates the wound healing process too. Many researchers are of the belief that age-old Egyptians and Greeks used Chamomile flowers on wounds to speed up their healing time. Though there is no established evidence as such regarding this subject, history stands witness to the magical healing properties of Chamomile in more ways than one. Diabetes patients are also in for some good news concerning Chamomile tea. Many ongoing studies and surveys conducted worldwide are hinting at Chamomile playing a role in diabetes management. Consumed regularly in the form of tea, the herb may arrest complications arising out of diabetes and may also prevent hyperglycemia. What's more, the golden herbal tea prepared from chamomile is caffeine-free and will not be addictive in any way. However, it is always a good idea to take professional advice before going all-out for Chamomile. Some people may display allergic reactions to the herb and suffer side-effects. Therefore, it is best to try the herb first in small amounts before one decides to include chamomile tea in the daily routine of life. Besides its therapeutic uses, chamomile is being increasingly used as an ingredient in cosmetic products and is being considered a good friend of the skin. Since Chamomile is known to be a stress-buster, a cup of chamomile tea after a hectic work day might just prove to be the right beverage to save the evening. With its sedative, anti-inflammatory and anti-bacterial properties and benefits, Chamomile is sure to become more popular by the day. Used wisely, the golden herb is no less than gold itself.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2743) glycine: a healthy amino acid
Date:
November 15, 2012 07:56 AM
For those who have heard about Glycine and wonder about its health benefits, they should first of all know that it's a proteinogenic amino acid with its name being a combination from the words glycogen and glucose. This is not an essential amino acid for the body, because it can be obtained from other sources. Nutritional Role Many studies have been performed around Glycine and the results show that it can be easily used in order to reduce the psychotic symptoms associated with schizophrenia and at the same time it can also be used to reduce symptoms that are associated with BPH or benign prostatic hyperplasia. Health benefits It seems that Glycine also has many benefits in nutrition and they are as following:
Importance Glycine is similar with many other amino acids and one of those similarities is in the fact that it has a great importance for the nervous system, more specifically in what regards understanding and memory. Due to the fact that Glycine work as a neurotransmitter, it has been successfully used in many treatments for hyperactivity, epilepsy and bipolar depression. Not only that, but it also supplies the human body with creatine which is vital for having healthy developing muscles. More to that, it also helps with maintaining a healthy prostate and with healing damaged skin. On the other hand, it seems that its uses are much broader and deeper, down to even helping out the body with detoxifying the liver and eventually helping with the calcium absorption process. Where is it found? People can easily get Glycine from foods like seeds, soya, gelatin, dairy and fish products, but also meat. In some cases, it's used as a sweetener and also in food supplements and protein drinks. Lastly, unless the individual needs this amino acid specifically, there is no need to actually get it, as the body can produce it unless for some reason the body mechanism that produces it is blocked. Then supplementation is essential to good health and wellness.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2715) What Causes Glycine Malabsorption?
Date:
September 09, 2011 04:33 PM
Glycine Glycine is known to be the smallest amino acid in the human body and it is present in both water and fatty based environments. This has been one of the most researched amino acid to date and most results indicate that it has an important role in normal bodily function maintenance. It has the ability to supply collagen to the human body as one of its main functions. Studies have also found that Glycine is also used to build both fibrous and muscle tissues which is why it has been used as a treatment for degenerative diseases. Aside from this main function Glycine also plays such a wide range of roles in other bodily functions as it is playing a part in numerous system processes, from aiding in blood sugar conversion to affecting the nervous system it truly has made itself essential to the body. That is why any malabsorption or lowering of Glycine levels in the body can cause harmful and detrimental effects in any person’s well being. Furthermore, it also has been proven in many studies that Glycine has an antioxidant effect which aids in the body’s war against free radicals. In recent years there has been an increase in the popularity of Glycine, so much so that some food products have been fortified with it just to up their value in the consumer’s eyes as they know that America is getting more and more health conscious as the days go by. Since the body is capable of producing this substance it is considered as a non essential amino acid. It is seldom that the body will totally run out of this substance however lowered levels due to various reasons are absolutely possible. Which brings me back to how is malabsorption of Glycine caused. Glucose and Galactose Presence Studies have been done to show how Glycine absorption can be impaired and what they were able to find out is that there is a competition between forms of sugar like glucose and galactose and Glycine for intestinal transport. The results show that there was a decrease in absorption of both substances whenever the other is present. For Glycine the drop in absorption was over 50 percent and for the sugars there was also significant decrease in uptake and absorption. What this entails in the real world is that regions with high carbohydrate diets maybe affected and may have cases of Glycine absorption impairment more so than other regions with lower carbohydrate diets however this is not taking into account any gastrointestinal damage that may also affect Glycine absorption. Anesthesia Administration In cases that a person has gone through surgery they may suffer from Glycine malabsorption, this is not something to be that worried about as anesthesia is not consistently present in the body and realistically very few individuals have surgery often and surgery that requires anesthesia I might add. Studies have shown that local anesthesia is the one that is more harmful to Glycine absorption compared to general anesthesia. If you have a Glycine malabsorption problem, supplementing with the amino acid will help restore these low levels. Grab some Glycine and feel the difference it can make in your energy.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2426) How Does Taurine Help the Brain?
Date:
May 13, 2011 01:09 PM
Taurine is an amino acid often added to energy drinks. There have been several theories on how taurine affects brain chemicals and improve cognitive function. For many years, it has been compared to caffeine due to its effects on the human brain that appear to enhance mood. Its exact mechanisms of action remain a mystery to the scientific community, but recent studies are believed to be closing in. It has long been known that taurine crosses the blood brain barrier, allowing it to exert some effects on several neurotransmitters found in the central nervous system. It has been tied to the alleviation of many mental illnesses, such as epilepsy, post traumatic stress disorder, clinical depression, bipolar disorder, and anxiety, making it the subject of a number of studies in the past few years. Rebalances Brain Chemicals It has been postulated that taurine influences the activities of neurotransmitters in the brain, but only recently has brain scientists been able to actually track its activities in the brain. A team of researchers at Cornell University managed to find a site for the neurological activity of taurine, with initial results pointing to its relationship with gamma the neurotransmitter aminobutyric acid, or GABA. The researchers do not discount the possibility that taurine may even have a receptor of its own. Whether taurine interacts with brain chemicals is no longer debatable as it creates homeostasis in the central nervous system. It acts on receptors that the researchers discovered to be the same receptors present in GABAergic mechanisms. That being said, scientists remain inconclusive as to how its interaction with GABA receptors provides energy-boosting benefits as it is marketed in the food and drug industries. Prevents Neuron Damage The scientific community is convinced that taurine has neuroprotective properties. High levels of taurine in the brain have been observed to protect brain tissues from cerebral ischemia. Taurine has been linked to many metabolic pathways that are known to promote neurological health, such as the activation of Glycine receptors and the regulation of enzymes called cysteine-dependent aspartate-directed proteases. In addition, taurine serves as antioxidants that protect nerve cells from cellular damage brought on by oxidative stress. The presence of taurine within cells reduces damage from calcium excesses and increases mitochondrial events. For decades, supplementation of taurine has benefited sufferers of brain ischemia, epileptic seizures, panic attacks, anxiety symptoms, and even alcohol withdrawal. Enhances Cognitive Function Taurine has already been associated with physiological functions the hypothalamus controls, such as sleep-wake cycle and responses to fatigue. In several laboratory studies, administrations of taurine by way of intraperitoneal injection have successfully induced social interaction in animal subjects. It is one of the amino acids that affect cognitive development, especially in children. While it is one of the most abundant amino acids in the brain, it is depleted as we age, making supplementation a good option. Protect your brain with Taurine by taking it daily!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2295) The Amino Acid Glycine Is A Component Of Collagen And Essential For Good Health?
Date:
March 23, 2011 03:45 PM
What Is The Amino Acid Glycine And How does it Work In the BodyGlycine is the smallest amino acid found in the human body. It is present not only in water-based environments but also in fatty tissues. Being one of the earliest amino acids to be discovered, it has been a subject of numerous studies in the last century. The abundance of data points to its indispensable role in maintaining the overall health of the body since it is quite ubiquitous at the cellular level. Supplies Amino Acid Requirement of Proteins in Cells It is a widely accepted fact that Glycine is an amino acid necessitated for the production of proteins that the human body uses and accounts for more than 30 per cent of the protein group called collagen. Human cells in particular utilize Glycine in manufacturing fibrous and muscle tissues, the reason why it has been in use in treatment of degenerative diseases. The total absence of Glycine in the human body is impossible, given the role it plays in protein synthesis, but low levels of Glycine can be harmful. Converts into Glucose and Helps Regulate Blood Sugar Glucogenic amino acids are a number of amino acids that can be converted into glucose. First on the list is Glycine, which does not only aid against a sudden drop in blood sugar but also provides the body with enough glucose to support cellular functions. Feelings of weakness characteristic of fibromyalgia and chronic fatigue are often attributable to an impaired capacity to produce enough energy. The process of gluconeogenesis converts non-carbohydrate compounds into glucose as a response. Displays Inhibitory and Excitatory Neuronal Activities While GABA is the primary inhibitory neurotransmitter in human beings, Glycine is also known to display inhibitory activities in the central nervous system. The spinal cord, brainstem, and the forebrain have all been identified to employ this amino acid in gylcinergic neurotransmission, which may be inhibitory or excitatory. It is postulated that Glycine plays a major role in various mental disorders, and several studies concerning its psychoactive potential are well underway. Scavenges Free Radicals and Reactive Oxygen Species Although it is not considered an essential amino acid, which means the body produces quantities adequate to support physiological functions, depleting levels of Glycine is not uncommon especially in individuals suffering from malnutrition and malabsorption. Glycine supplements have seen a surge in popularity in the latter half of the century as they are also known for their antioxidant activities. Enzymes responsible for antioxidant defenses necessitate Glycine, which is an antioxidant in itself. Supplementation of Glycine has risen in the past few years especially when studies associating this amino acid to degenerative diseases have started to surface. A number of scientists believed that age-related and other degenerative diseases such as arthritis and osteoporosis may be classified as deficiency diseases in that these diseases can easily be prevented or reversed with diet modifications. The incorporation of Glycine in food products has also been reported to contribute to the upkeep of protein complexes needed by joints, muscles, and other parts of the body.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2256) Glutathion, Antioxidants, And The Body
Date:
July 14, 2010 02:41 PM
Glutathione is an important water-phase antioxidant that is an essential component in the glutathione peroxidase system. Glutathione peroxidase enzymes are crucial for detoxifying peroxides including hydrogen peroxide, which is generated within cellular membranes and lipid-dense areas of the cell, especially the mitochondrial membrane. Severe glutathione depletion often leads to cell death, while experimental glutathione depletion has been found to induce cellular apoptosis. A cellular level of glutathione depletion seems to cause extensive damage to the mitochondria. Depletion of mitochondrial glutathione may, in fact, be the ultimate factor that determines a cell’s vulnerability to oxidative(free radical) attack. The mitochondria is the most crucial place for glutathione presence, as the cascade of oxidation-reduction reactions complete the final steps in respiration take place here. Throughout this process, which is called oxidative phophorylation, electrons invariably escape and react with the ambient oxygen in order to generate toxic free radicals. It has been estimated that 2% to 5% of the electrons that enter the mitochondria are converted into reactive oxygen species that generate considerable oxidative stress for the cell. These free radicals cause an immediate threat to other cellular components, such as the DNA, enzymes, structural proteins, and lipids. The cumulative damage that is caused by oxygen and other free radical species is now determined to be the principal contributor to the degenerative disease process and the progressive loss of organ function that is commonly recognized as aging. Because of this, the cell is constantly challenged to destroy these free radicals before they can inflict any lasting damage. Minimizing oxidative attacks may actually be the ultimate challenge of being alive. Because of this, the reducing power of glutathione is of huge important to the cell. Glutathione is important for helping to regenerate other antioxidants that are depleted from their constant work to fight off free radical challenges. Regeneration that is glutathione-induced may be the mechanism that is actually used by the cell in order to conserve lipid-phase antioxidants, vitamin A, vitamin E, and the carotenoids. It has been confirmed by recent investigations that dietary vitamin C can actually protect us against tissue damage that results from glutathione depletion. Additionally, supplementation with glutathione or its precursors can also quickly replenish any vitamin C deficiencies. Because of this, glutathione and ascorbic acid, both of which are pre-eminent cellular antioxidants, are tightly linked, as glutathione can conserve vitamin C and vitamin C can conserve glutathione. When they are both present, these two antioxidants protect the entire spectrum of biomolecules that are found within the cell, as well as facilitate the cell’s best performance. It has been said that the glutathione status of a cell may be the most accurate single indicator of the health of the cell. This means that as glutathione levels go, the health of the cell will go as well. Glutathione is available in capsule or tablet form at your local or internet health food store. Always choose name brands to ensure quality and purity of the glutathione supplement you choose to purchase for consumption.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2171) Lomatium by Planetary Herbals
Date:
June 03, 2010 12:16 PM
The resinous roots of lomatium dissectum were extensively used by indigenous peoples of the Pacific Northwest and Northern Nevada were the plant grows. Lomatium, a perennial plant that sprouts and flowers in early spring, was often called “biscuit root” since the pulp was pounded into cakes, or “Indian carrot” due to its resemblance and kinship with carrots. Support for the Respiratory and Immune Systems Native Americans gather the lomatium dissectum plant in late fall, and use it to enhance respiratory health. Modern research indicates that certain compounds in lomatium may stimulate white blood cell activity (Phagocytosis). Phagocytosis is a process that is part of the body’s first line of immune defense.
Two Beneficial Liquids Planetary Herbals full spectrum Lomatium is available in 1:3 root extract, prepared with grain alcohol (70%) and purified water. Also, alcohol free full spectrum Lomatium Glycerite. Both products can be taken in water, or made into a tea and sipped. This ancient and renowned herb can enhance our health year round. The PhytoDynamic Difference Planetary herbals Full Spectrum Lomatium was developed with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. The result: herbal products unsurpassed for quality and consumer satisfaction.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2166) L-Methionine
Date:
May 02, 2009 11:41 AM
Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body. Maintenance of Cell Membranes It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-adenosylmethionine. This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids. Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics. A by-product of this reaction is homocysteine, formed in the liver from the S-adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis. Muscle Development Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, Glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue. Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows. Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow. Detoxification of the Liver Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine. Methionine and Autism Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals. Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below. Miscellaneous Benefits Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system. It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract. Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems. So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most. Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800mg - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine. Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement. Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2002) NOW Foods is the Leading Brand for Amino Acids in Health Food Stores
Date:
April 29, 2009 04:16 PM
-Michael Lelah, Ph.D. / Technical Director It was recently announced that NOW Foods is now the leading brand for the amino acid segment in Health Food Stores. We sell over 100 different formulas of single and multiple amino acids in powder, capsule, tablet, and liquid forms. We cover the alphabet from L-Arginine to L-Tyrosine, with high potency products such as Acetyl L-Carnitine 750 mg, 1,000 mg L-Carnitine Tartrate, and our new 1000 mg L-Tryptophan Tabs coming in June. Most amino acids come in two optical forms – the L-form and the D-form. The L-form is the only true natural form, while the more common D- and DL-forms are synthetic. At NOW Foods, we only carry the natural L-form. This is the safest form, naturally found in foods and in the human body. Taurine and Glycine have no optical rotation, and therefore occur in only one natural form with no L- or D- designation. Our L-amino acids are of the highest quality available, and our ingredient powders conform to USP standards. The USP standards cover identity, purity and potency testing. This means that each lot of amino acid ingredient is tested to ensure that (a) it really is the amino acid we say it is, and not something else, (b) it’s pure to the highest USP standards, and (c) it has the full potency that you require. At NOW Foods, we take our amino acids seriously, and we even go beyond the USP level of testing when we believe it is necessary. For example, every lot of our L-Tryptophan is tested to ensure that it is free of Peak E. This is the impurity which is believed to have been responsible for serious adverse events twenty years ago. We rigorously enforce this standard, and this goes beyond USP requirements. We have rejected a number of lots of L-Tryptophan because of the presence of Peak E. We will not sell you these rejected materials, and we hope that others do not as well. We can’t control what others do, but we can control what we do and we assure you of L-Tryptophan tested to be free of Peak E. Our state-of-the-art analytical labs allow us to perform our own testing on our amino acids to doubly ensure their quality. We have 9 HPLCs that we use every day to test and retest our aminos to confirm their potency, purity and identity. We have very strong analytical, professional, and technical staff members who have many years of experience in testing amino acids. So much so that we are involved in developing industry validated methods for L-Carnitine and L-Arginine. NOW scientists are setting the standards for amino acid testing. Most amino acids are quite stable and they can be packaged in standard containers. These amino acids will maintain their shelf life through their Best By date, and we test to make sure they do. SAMe however, is a uniquely unstable amino acid compound. Because of this, we provide triple protection – glass bottles, moisture control and oxygen control. SAMe is distinctly susceptible to oxygen degradation. We are the only major brand to offer our SAMe packaged with Ageless® oxygen absorbing packets, which remove integrity-challenging oxygen from every bottle to reduce degradation. We go that one step further to protect our products! Finally, we’re the leading amino acid brand because our products work. As an example, in a published study2, our SAMe was directly compared against the leading drug – Celebrex®. NOW Foods brand SAMe performance was the same as the drug supporting joint health, but without the pharmaceutical side effects. All in all, we are not the leading brand in this category just because of our great prices. We have significant science and quality behind all of our products, not just amino acids, and we hope that you consider our rigorous efforts in quality assurance, safety and efficacy when making a purchase. 1. SPINScan Natural Channel, 52 weeks ending 02.21.09. 2. Najim, W.I., et al, SAMe versus celecoxib…, BMC Musculoskeletal Disorders 2004, 5:6.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2000) Protect The Liver with Glutathione And Cysteine
Date:
April 23, 2009 01:54 PM
The tripeptide L-glutathione is synthesized in the body from L. glutamic acid, L-cysteine and Glycine, a reaction that can occur in any cell of the body although it is essential that it also occurs in the liver. Should glutathione concentrations drop, they can be increased by supplementing with cysteine or any other of the three amino acids that are used in the biosynthesis of this important if substance The tripeptide exists in two forms: the reduced form (GSH) which contains a sulfhydryl (SH) functional group attached to the cysteinyl part of the molecule, and the oxidized form glutathione disulfide (GSSG). As electrons are lost from the reduced form, two molecules combine to create a dimer formed by a disulfide bridge, the process which can be reversed through reduction of the GSSG. Such electrons are lost during its reaction with free radicals, in which the free radicals are neutralized by the donation of an electron from the oxidized version of glutathione. The definition of a free radical is a molecule that is lacking one electron from an electronic pair. Its prime purpose is then to steal an electron from the nearest molecule to it. In doing so, it can not only destroy that molecule, but also destroy body cells and lead, not only to premature aging, but also to some potentially fatal conditions. It is an unusual peptide in that it involves a link between the cysteine amino grouping and the carboxyl functional group of the glutamic acid. It is a powerful antioxidant, acting as an effective free radical scavenger and protecting the body cells from the effects of free radical oxidation. However, it is on its detoxification effect in the liver that we shall focus here prior to discussing some other uses to which the body puts glutathione in its two manifestations. Much of the detoxification is connected with the thiol group in the molecule. Take mercury for example. The thiol grouping forms a strong Hg-sulfydryl chemical bond within the liver, in the form of a glutathione-mercury chelate. In this form mercury is unable to exert any toxic effect on the body and can be excreted in the normal manner. The same reactive pathway is followed by other heavy metals that can bond to thiol groupings. In this way L-glutathione can protect the liver from the effects of a number of toxic heavy metals such as cadmium and chromium. This is an important property of the amino acid, particularly in industrial and urban environments where the population is more prone to exposure to heavy metals than their rural counterparts. However, the end result on the glutathione is that it is removed from the body, and, particularly with city dwellers, a supplement may be required to maintain a healthy concentration of this amino acid in the body and in particular in the liver. Therefore, although L-glutathione is not considered an essential amino acid, in that it is biosynthesized within the body, a supplement is sometimes required, particularly by those who live in large cities. It is important to consider the form in which the glutathione supplement is administered. This is because of the presence of gamma-glutamyltranspeptidase within the digestive system. This enzyme appears to destroy L-glutathione before it can be absorbed in the intestine so normal oral forms of supplementation are likely to be ineffective. Possible forms of effective administration include buccal (between the cheek and teeth) and hypodermically. An alternative means of supplementation is to take substances such as selenium, methionine, alpha-lipoic acid, vitamin C and glutamine that stimulate the biosynthesis of glutathione. Also, since the substance utilizes the raw materials of L-cysteine, glutamic acid and Glycine in its intracellular production, supplementation with these amino acids should also help to produce L-glutathione. That said, let's return to its antioxidant properties and its effect on the liver that contains the largest stocks of glutathione in the body. It is generally regarded as the most important antioxidant in the body. It protects cellular cytoplasm from oxidation by reducing disulfide groups and maintaining a highly reducing environment within the cytoplasm. It reacts with hydrogen peroxide and other oxidative agents, and is converted to the oxidized form GSSG. It is then reduced back to GSH through the combination of the reducing agent and an enzyme. The reducing agent is nicotinamide adenine dinucleotide phosphate (NADPH), the enzyme being glutathione reductase. The implications that this strong reducing effect has on the liver are significant. Reduced GSH L-glutathione levels have been found in patients suffering from HIV, hepatitis C and other liver diseases. Supplementation with GSH has been found to restore normal levels of glutathione to the liver, and it has been demonstrated that the treatment has improved such conditions significantly. Atherosclerosis is a condition of the arteries caused by the deposition of plaques formed from oxidized low-density lipoproteins, otherwise known as bad cholesterol. The strong antioxidant effect of GSH prevents this from LDLs from being oxidized and deposited on the arterial wall. There are other results of glutathione supplementation that indicate the effectiveness of antioxidants in the treatment of serious liver conditions, and there are no doubts that combating the effects of free radicals and oxidizing agents within the liver has a positive effect on many potentially serious liver diseases. Many of these are exacerbated by the generation of free radicals by relatively modern pollution sources such as pesticides, petrol and diesel emissions, tobacco fumes and various other chemical emissions. A strong antioxidant such as L-glutathione cannot be anything other than an effective means of reducing the biological effect of these oxidants. It protects not only the liver but also the lungs and cardiovascular system. For all these reasons a supplement consisting of L-glutathione or its constituent parts, glutamic acid, cysteine and Glycine, provide significant protection against the stresses and strains of modern living. Increased pollution levels and heightened oxidative stress levels within the body are playing havoc with our body defenses, and GSH is an important one of them that can easily be enhanced by supplementation. There are no known reactions to L-glutathione supplementation, but pregnant women and babies should receive expert medical advice prior to taking it.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1996) L-Alanine Non Essential Amino Acid
Date:
January 05, 2009 04:31 PM
L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry. Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein. 10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms. L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and sustained running, muscles produce lactate and also alanine. The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy. The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-ketoglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose). The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea. In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction. L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and Glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition. A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high. Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps. Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, Glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure. Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.
Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1958) Glycine
Date:
October 11, 2008 10:26 AM
The non-essential amino acid Glycine is needed to generate muscle tissue and also for the conversion of blood glucose into energy. It is referred to as being ‘non-essential’ because the body can manufacture its own Glycine, and is therefore not an essential component of your diet. Other uses to which Glycine is put by the body includes the maintenance of a healthy nervous system, and is necessary for the proper functioning of the digestive system. Amino acids play three essential roles in the human body: 1. They are the building blocks of proteins: proteins comprise about half of the dry weight of the majority of your body cells, and without them there would be no life. They are produced using monomers known as amino acids, and there are about 20 different amino acids used to make the vast variety of proteins that make up the human body. Proteins are needed to form enzymes, the catalysts that permit the majority of chemical reactions within our bodies, and also genes, the building blocks of DNA. 2. More relevant here, amino acids play an important role in the production of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) by phosphorylation with creatine phosphate. The more creatine phosphate available, the more ATP can be produced. Since ATP is the molecule responsible for the generation of energy, then the more ATP available the more energy is generated. Although creatine is available from many food sources, it is destroyed by cooking, and over half of what you use is made from the three amino acids, Glycine, arginine and methionine. The energy produced in this way is very short-lived, and last only a few seconds - more on that later. 3. Glycine is heavily involved in the production of collagen, which is the substance that maintains the flexibility of your skin and other connective tissues while still maintaining their strength and firmness. Without Glycine your skin would become slack due to the degrading effect of sunlight, free radicals and oxidation. The non essential amino acid, Glycine, is believed to offer other benefits to the human body, but it is the second of those above, the production of ATP, which interests us here. ATP is an extremely important nanomolecule, second in importance to the body only to DNA, and possibly also RNA since the two are linked. RNA makes copies of your DNA structure for use in cell division and growth. When a cell expends energy for whatever reason, such as when I am typing this, or when your heart beats, or even when your liver synthesizes a protein, one of the phosphate groups is removed from the adenosine triphosphate molecule, and converts it to adenosine diphosphate (ADP). The ATP is then said to be 'spent', just as your energy is spent when you are tired and can exercise no more. The ADP is then immediately reconverted to ATP in the mitochondria, a part of every cell in your body. A cell can contain hundreds, or even thousands, of mitochondria, the number depending upon that particular cell's need for energy. Hence, cells in your muscles, or in your liver where most of the body's chemistry takes place, contain thousands of mitochondria whereas those in your scalp contain a lot less. Once changed to ATP, a phosphate is again lost when energy is expended, and so the cycle continues. Glucose is needed allow the ADP to be converted to ATP, hence the need for sugars, or the carbohydrates from which they are manufactured in your body. Each cell can contain up to a billion molecules of ATP, although the couch potatoes among you probably have a lot less! Your store of ATP molecules last about 2 to 5 seconds before being changed to ADP although more rapidly for athletes that expend a lot of energy. Then the energy stored in the form of glycogen in the liver kicks in for another 4 - 6 seconds. Additionally, you cannot expend more energy that the (eventual) sugars that you take in your diet, which can be in the form of ordinary 'sugar' (sucrose), fruit (fructose), glucose, carbohydrates that are metabolized into sugars, or any other member of the sugar family (e.g. lactose, maltose, etc.). Glycine is one of what are called glucogenic amino acids, which refers to their ability to provide glucose to the blood. Because it helps to maintain proper blood glucose levels, it is often prescribed for conditions that are caused by low glucose levels, such as hypoglycemia that shows symptoms of fatigue and tiredness, and also anemia and what is known as CFS (chronic fatigue syndrome). The one activity of the human body, in fact that of any mammal, for which ATP is essential, is the heartbeat. Without that no mammal could survive, or any other creature that relies on a circulation system for life. The only reason you heart has to beat is to pump your blood around your body, and it is your blood that contains the oxygen and nutrients needed to sustain life. Your cardiovascular health relies on lots of ATP being available to power each and every heartbeat. Analysis of the heart during the final stages of heart failure has revealed that there is a general decrease in the myocardial arginine: Glycine amidinotraferase (AGAT) gene expression, which is indicative of the necessity of this enzyme for proper heart function. The enzyme is responsible for the first stage in the biosynthesis of creatine from Glycine. Creatine is well known to athletes, and while it is available naturally from some food sources, it can be destroyed during cooking, and at least 50% of the creatine needed by the body is produced in the liver, pancreas and kidneys. It is creatine phosphate that is broken down into creatine and phosphate, the latter of which is used by the mitochondria to regenerate ATP from ADP.
The study carried out on the reduced AGAT levels found in heart failure patients indicates the importance of Glycine to heart health. Without a good supply of Glycine, there will insufficient creatine produced biochemically to generate the phosphate needed to for the ATP to produce the energy required to keep the heart pumping with the required strength. The energy provided by the mitochondria is used locally by the cells in which it is produced, and within a few seconds of that production. As explained earlier, ATP stores are used up within 2 - 5 seconds, and glycogen stores within another 4 - 6 seconds. That is why sprinters cannot keep running at maximum speed for more than around 10 seconds or so, because the immediate availability of Glycine, and hence creatine, are insufficient to last longer than that. That is one reason why they have to finish those 100 meters as fast as possible, because otherwise they would run out of energy. Other than trying to win, of course! However, when it comes to the heart, ATP stores are essential, and the cells in your heart require a constant supply of ATP from creatine, which itself depends upon your intake or biosynthesis of Glycine. Since dietary sources are insufficient to meet all your needs, and destroyed by cooking, a Glycine supplement is the only way to ensure a sufficient intake. You cannot undernourish your heart and remain healthy.
ATP biosynthesis is essential if that of Glycine theoretically is not, but the fact that 50% of your Glycine requirement has to be produced by your body and the other 50% is sensitive to heat during cooking, a supplement of Glycine could be essential to many people.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1912) Supports Healthy Blood Pressure
Date:
April 18, 2008 03:59 PM
3 tablets contain: Suggested Use: 3 tablets mid-morning and 2 tabs mid-afternoon between meals on an empty stomach.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1763) L-Glutathione Can Eliminate Toxins in the Liver
Date:
December 07, 2007 11:54 AM
L-glutathione is the reduced form of glutathione, and is a tripeptide synthesized in the animal and plant tissues from Glycine, cysteine and glutamate. Commonly known as GSH, it contains thiol groups that are maintained in a reduced state, and is a very powerful antioxidant, considered to be the key antioxidant and protective substance in the body. Glutathione can reduce any disulfide groups in the cytoplasm within the body of the cell, and ensures that the cytoplasm is a strongly reducing medium protecting against oxidation. It has a synergistic effect with other antioxidants to protect the body against free radicals and oxidizing agents that cause so much damage to the body through what is commonly referred to as ‘oxidative stress’. However, there is more to it than that and it attaches itself to toxic chemicals and drugs in the liver and renders them into a state suitable for elimination from the body. These toxic materials include poisonous pesticides, hydrogen sulfide, carbon monoxide, heavy metals such as mercury, cadmium and chromium and many other substances that we come into contact with due to present day pollution of our atmosphere and foodstuffs. Glutathione can also help protect the body from the effects of chemotherapy and evidence is suggesting possible links with the control of some cancers, diabetes, atherosclerosis and many other degenerative conditions caused by free radical attack and the effects of pollutants. The way that GSH acts in the cells is that the redox state of the glutathione-glutathione disulfide couple is critical to the health of the intercellular and intracellular fluid. GSH in the reduced state of glutathione reacts with an oxidative agent such as hydrogen peroxide to form the oxidized form, glutathione disulfide and water. It hence mops up oxidizers such as peroxides and free radicals within the cytoplasm of the body’s cells, and also in between the cells. The disulfide is then converted back to GSH by the combined action of the enzyme glutathione reductase and NADPH (the reducing agent nicotinamide adenine dinucleotide phosphate). The cycle then repeats so that two molecules of glutathione continue to reduce damaging oxidizing agents without themselves being consumed. In so doing, the NADPH becomes oxidized. A continuous supply of NADPH is needed to allow GSH to undergo these biochemical reactions, and up to 10% of our blood glucose is used by the pentose phosphate pathway by which NADPH is synthesized. Since this cycle consumes no glutathione, it would appear that a supplement is unnecessary. However, this is not the case since the molecule takes part in other reactions in the body, particularly in the elimination of toxic heavy metals from the body. Mercury is highly reactive with the thiol that GSH is, and so will bind to form a stable Hg-sulfydryl bond in the liver. This mercury-glutathione chelate is unable to bind to other proteins or gain access to the body cells, and is eventually harmlessly secreted. The same is true of many other heavy metals that are reactive with thiol’s. In this way the body is protected from the harmful effects of these heavy metals. However, it results in the loss of the glutathione, and the pollution of modern day living can take a heavy toll of the GSH content of our bodies. For this reason a glutathione supplement is recommended, especially for city dwellers that may be exposed to more heavy metals than those residing in rural areas. However, the form in which this supplement is taken is very important, because the human digestive tract contains a significant amount of gamma-glutamyltranspeptidase. That is an enzyme which apparently destroys glutathione before it can be absorbed. However, it can be absorbed directly into the bloodstream by dissolving the pill between the teeth and inner cheek. It has also been suggestion that the supplement could be administered by injection. Others have suggested that rather than administer a supplement, individuals could take other supplements that contain the materials needed to stimulate the formation of GSH. Substances such as vitamin C, selenium (important in GSH biochemistry), methionine, alpha-lipoic acid and glutamine could all help to increase the body’s production of glutathione. A supplement of the constituent parts of cysteine, Glycine and glutamic acid should also help. The dosage ranges recommended vary widely from 50mg to 500mg daily, and the effects of supplementation are not yet well know. Some specific conditions that this wonder antioxidant is useful in treating include liver disease such as hepatitis, cirrhosis and so on. Patients suffering from these diseases show a massive reduction in their GSH content and prior GSH treatment appeared to offer a significant degree of protection in controlled clinical investigations. Patients suffering from chronic hepatitis C have been found to be associated with reduced GSH levels, particularly if also HIV positive. Similar deficiencies have been noted in some lung conditions such as asthma and other pulmonary conditions. In such cases it has been demonstrated that administration of GSH supplements sufficient to restore normal levels of the substance improved the patients’ conditions by a significant amount. Its effect on atherosclerosis appears to be significant since a decreased level of GSH peroxidase has been recorded in such patients in addition to an increase in lipid peroxides, indicating that oxidation of the arterial wall had been occurring. Anti-viral therapies that rely on GSH biochemistry for their action have been found to be less effective in those with low GSH levels, and other studies have confirmed that supplementing with GSH improves the response to interferon treatment. These results indicate the activity of oxidizing agents and free radicals in liver conditions, and in fact this has been demonstrated by tests carried out in New York and Philadelphia in the 1990s. This suggests that the liver is prone to damage by oxidative stress, and that GSH levels may be able to be used as an indication of potential liver disease. What is evident is that a strong case can be made for glutathione supplementation as protection against potential liver, pulmonary and cardiovascular diseases, especially by those exposed to specific polluting agents such as primary or secondary tobacco smoke, auto and diesel fumes and chemicals and pesticides. L-glutathione is useful, not only for the elimination of toxins in the liver, but also in protecting this large and vital organ from the oxidative stress that modern living brings. L-Glutathione and its precursors are sold over the counter at your local or internet health food store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1649) Supplements good for reducing stress and boosting energy!
Date:
March 26, 2007 02:05 PM
Vitality 101
More and more Americans are feeling overworked, overtired, and overcome by life’s demands. We just do not have the energy we need to meet our responsibilities to the people we care about. More importantly, we don’t even have the energy to have fun! It seems that a constant feeling of fatigue has become part of the American way of life.
Research has shown that the same processes that cause lack of energy can rob us of sleep, saddle us with excess weight, disrupt our hormonal balance, and create significant amounts of stress in our daily lives. Chronic stress can dramatically contribute to fatigue, sleep disorders, irritability, and anxiety. The research simply confirms what most of us already know – uncomfortable stress can really wear us out mentally and physically! It can take away the satisfaction of a job well done. It can take away our ability to believe in ourselves. And, sadly and maybe most importantly, continual stress can take the fun and joy out of life.
In a separate issue of Ask the Doctor, we discuss the energy and sleeping needs of people suffering from chronic fatigue syndrome and fibromyalgia. In this issue, I discuss the 3-step process I call “Vitality 101.” People do not have to accept pain, insomnia, or fatigue. It’s time for everyone to feel great and have a life they love!
Step 1 – Nutrition
Good overall nutrition is important for everyone! As a foundation product to support energy levels, a powdered drink mix is a pleasant, easy way to ensure that you are taking all of the necessary vitamins, minerals, and amino acids that you need to have great energy all through your day.
The following chart lists the most critical ingredients. You can see that almost all of the vitamins and minerals work together to help improve energy levels and overall health.
In addition to the powdered energy drink mix, it is important that you also take a high potency vitamin B-complex supplement. This should include niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, which are especially important to restore the energy production needs of your body. It is also critical to get enough water, as most Americans are chronically dehydrated.
Step 2 – Rest Your Body
Having trouble sleeping is one of the most troubling symptoms of stress. While the stress is wearing us down and making us tired, it’s also keeping us tense and unable tot relax. The result? That easy drift into sleep becomes harder and harder. And if we are lucky enough to actually get some shut-eye, stress will often wake us up, sometimes several times a night.
This occurs because excess stress suppresses the sleep center in the brain. It is important to break the “stress/insomnia cycle” early, before it results in pain and hormonal and immune dysfunction!
Because good quality sleep is how the body repairs and re-energizes itself, it may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Look for a supplement that has a blend of herbs that promote deep sleep, such as valerian, L-theanine, hops, passionflower,
Step 3 – Manage Excess Stress Levels
In this fast paced world, it is important to learn to manage the stressor in our lives. Glandular extracts, such as raw adrenal extract, can offer natural support to help our bodies deal with the effects of stress and, in turn, can boost your energy levels. Exercise is another stress buster. Using your body physically is important for good health. Find something that is fun for you, however, or you are unlikely to stick with it!
Q. Does stress zap my energy in any other ways besides making me lay awake at night and causing me to be a zombie the next morning?
A. Most people are familiar with the body’s dramatic response to an emergency. The heart pounds, the muscles constrict, and the lungs expand – and while this is happening, we are capable of greater than normal strength and speed. This response is the body’s way of rescuing itself when faced with an emergency. We don’t have to think about it to make it happen. It’s automatic.
The same can be said of a chronic stress response. Whether we’re late for a business meeting because we’re stuck in traffic, or worrying about how we are going to pay for our children’s college tuition, our response to stress happens automatically. The difference between the two is that the body’s response in an emergency starts and resolves itself quickly. The response to being stuck in traffic may not.
The body makes the “stress hormone”, cortisol, to handle the normal stresses of day-to-day living. But in an emergency situation, the adrenal glands, located above the kidneys, secrete increased amounts of this hormone until the emergency passes. Then the body returns to its normal function. Unfortunately, however, chronic stress is more complex. When our body is subjected to increased amounts of the hormone, cortisol, for an extended time, it can lead to a condition known as “adrenal burnout” or “adrenal fatigue.” While it’s true that very large amounts of cortisol can have damaging effects on our hormones, too little cortisol doesn’t allow us to respond to stress properly. It’s really a matter of balance.
Q. How can I control the stress in my life and re-energize?
A. Many people who are under constant stress may have adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress.
The good news is that changes in our hormone levels can return to normal when stress is decreased. The key in learning how to deal with daily stress is to allow the body to return to its normal state. I discuss additional techniques for coping with stress in my recent book Three Steps to Happiness! Healing Through Joy (see my website, www. jacobeitelbaum .com, for more information). In addition to stress control, it is important to supplement your adrenals with a glandular therapy regimen to ensure healthy cortisol levels and adrenal function. Glandular therapy, which uses the concentrated forms of bovine (cow) or porcine (pig) glands, can improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacked and thus repaired the malfunctioning gland.
Adrenal Extract
If you are one of the unlucky folks with stressed-out adrenal glands, you should see great results from taking raw adrenal supplements. Be sure to buy adrenal extract supplement that contains both whole adrenal and cortex adrenal.
The best adrenal supplement should also contain vitamin C, vitamin B6, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients.
Liver Extract
Did your grandmother ever tell you to eat your liver so that you didn’t get “tired blood?” Well, it turns out that she was right. Liver extract is another glandular extract that can help improve energy levels.
Liver extract is an excellent source of highly bioavailable nutrients including iron, B vitamins (especially B12), and other minerals. The stamina and energy-enhancing benefits of liver are widely touted. Liver extract has been shown to support healthy function of the liver and increase the energy levels inside our body.
Because heat will destroy the key components in the liver, a high quality liver extract supplement should be cold-processed and encapsulated to enhance speed and absorption of nutrients from liver. A high quality aqueous liver extract supplement should also contain vitamin B12 to support healthy blood iron and oxygen levels to energize.
Q. It will be great to get a good night’s sleep. Are there also any other natural alternatives that could help promote relaxation and increase my energy levels during the day?
A. Yes, there are. Rhodiola rosea is an all-natural herb that has long been used to help relieve stress and increase energy. Rhodiola has also been used to lift our moods, improve sexual satisfaction, and even help in certain nervous system disorders. First used in Siberia and
In clinical trials, the most effective Rhodiola rosea extract was found to contain 3% rosavins and 1% salidroside. While there are many Rhodiola supplements in health food stores, only those containing these specific amounts can provide the best results.
Lifestyle Treatments
Altered digestion, food intolerances, decreased energy, fatigue, cognitive problems, and sleeplessness create the need for changes in daily living routines. These can include alterations in diet; exercise modifications; alterations in activities of daily living according to one’s energy level; and sleep/rest management. All may require the assistance of a professional clinician, such as a chiropractor, nutrition specialist, physical and/or occupational therapist, mental health professional, or sleep therapist.
Conclusion
Super busy lives demand super strength nutrition. Begin each day with a powdered nutritional supplement after getting at least 8 hours of sleep each night. In addition to the nutritional beverage mix, a vitamin B complex supplement should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients to combat your fatigue. Taking a daily adrenal supplement, like the one discussed earlier, will provide the much needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy. Rhodiola rosea, and ginseng can offer additional natural nutritional support in your busy life to boost your energy levels. These nutritional supplements can be used daily and you will feel energized to get through each day’s challenges and opportunities!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1496) Chronic Fatigue Syndrome and Fibromyalgia
Date:
February 28, 2007 12:02 PM
This is a fast paced world. We are all busy; living our full lives, burning the candle at both ends. We all get tired. We all get sick from time to time and maybe even depressed. But the illness called chronic fatigue syndrome is not like the normal ups and downs that we experience in everyday life. People with chronic fatigue syndrome feel overwhelming fatigue, and often pain as well. This is an illness that does not go away with a few good nights’ sleep. It drags on and on and doesn’t resolve itself. It steals vigor and energy over months, and sometimes even years. In this issue of Ask the Doctor, we will talk about powerful vitamins, minerals, amino acids, and herbs combined in scientifically validated formulas that people with chronic fatigue syndrome or fibromyalgia can use every day. These nutrients help address some root problems of chronic fatigue syndrome and fibromyalgia by restoring energy and health to sufferers. Q. What is chronic fatigue syndrome? A. Chronic fatigue syndrome (CFS) also known as chronic fatigue and immune dysfunction syndrome (CFIDS), or myalgic encephalomyelitis (ME), is a group of symptoms associated with unrelenting and debilitating fatigue. The profound weakness of CFS causes a persistent and substantial reduction in activity level. You feel too tired to do normal activities or are easily exhausted for no apparent reason. Besides extreme fatigue, symptoms of CFS include general pain, mental fogginess, flu-like symptoms, and gastrointestinal problems. A list of symptoms includes:
The number of symptoms and the severity of these symptoms can vary among people. The symptoms of CFS hand on or reoccur frequently for more than six months. Q. Are chronic fatigue syndrome and fibromyalgia considered being the same illness? A. Fibromyalgia syndrome (FMS) is a painful shortening of muscles throughout the body. FMS is basically a sleep disorder characterized by many tender knots in the muscles. These tender knots, called tender or trigger points, are a major cause of the achiness that people with fibromyalgia and CFS feel. Approximately 80 percent of chronic fatigue syndrome patients have received and overlapping diagnosis of fibromyalgia syndrome. For most people, fibromyalgia and chronic fatigue syndrome are the same illness. Q. What causes chronic fatigue syndrome? A. There are many causes that can trigger CFS. Current research is looking at the roles of neuroendocrine dysfunction, viruses, environmental toxins, genetic predisposition, food sensitivities, yeast overgrowth, faulty digestion, or a combination of these factors. For many people, CFS is triggered by a bout with a viral illness (like a cold or the flu), or even a stressful event. CFS is usually a mix of underlying causes. It is like a domino effect in that each problem can trigger another problem, and so on. For example, fatigue and poor sleep can trigger a weakened immune system, which can, in turn, trigger yeast or bacterial infections. Q. Who gets chronic fatigue syndrome? A. CFS is more common than you might expect. It strikes people of all ages, racial, ethnic, and socioeconomic groups. Approximately 800,000 people nationwide have CFS and over six million have fibromyalgia at any given time. It is important to stress that CFS is a real illness; it is not “just in your head.” Unfortunately, sufferers of CFS may find that many healthcare practitioners discount the symptoms of this illness or misdiagnose it as another disease. This can lead to additional emotional suffering. Q. How long does chronic fatigue syndrome last? A. The illness varies greatly in its duration. Some people recover after a year or two. More often, those who recover are more likely to do so three to five years after onset. Yet for some people, the illness seems to simply persist. There are rare cases of spontaneous improvement after five years without undergoing any treatment. However, this is very unusual. Q. What are the complications of chronic fatigue syndrome? A. The patterns of CFS vary from individual to individual. However, many common patterns of symptoms are seen in CFS sufferers. These symptoms and problems interact and create new symptoms and problems. For example, infections and disrupted sleep can lead to digestive, hormone, and immune problems. Infections The most notorious pattern seen in CFS is the one in which a person suddenly comes down with a flu-like illness that doesn’t go away. These viral or bacterial infections can suppress the body’s master gland, the hypothalamus. Since the hypothalamus controls the other glands, including the adrenals, ovaries, testes, and thyroid, suppression of this gland will lead to a subtle but debilitating decrease in the functioning of all glands and their hormones. Suppressed hypothalamic function from chronic infections can then trigger sleep dysfunction. Disrupted Sleep The suppression of the hypothalamus gland can lead to poor sleep because the body confuses its day/night cycles. Because of this, people with CFS have trouble staying in the deep, restorative stages of sleep that “recharge their batteries.” Poor sleep can cause immune suppression, which may lead to secondary bowel infections. The bowel infections seen in people with CFS can cause decreased absorption of nutrients, which can lead to chronic vitamin and mineral deficiencies. Q. Is there a cure for chronic fatigue syndrome? A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study ( of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’. An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient. Medical Treatments Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for pain, sleep disturbances; digestive problems such as nausea, depression and anxiety, and flu-like symptoms. However, medications have not been universally successful because they tent to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems. Supportive Treatments People with CFS/FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness. Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage. Daily Nutritional Supplementation for Energy Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula: Vitamins, Minerals & Other Key Ingredients Vitamin A: Essential for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone growth and healthy reproductive processes. Vitamin A in the form of beta-carotene is an antioxidant and free radical fighter. Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep. Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine. Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutraphils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier. Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain. Inositol: Enhances immune function by increasing natural killer cells. Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism. Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation. Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for the production of energy in the body. Also essential for brain function. Zinc: Supports the immune system by enhancing neutrophils activity and supporting healthy antigen-antibody binding. Selenium: Supports immune function by enhancing antibody production. Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora. All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness. B Vitamin Complex for Energy In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B6, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. It is also important to make sure that the dosages are high enough CFS/FMS needs. The chart in the next column lists the B vitamins that are critical for people suffering from CFS/FMS. B Vitamins Effect on Chronic Fatigue Syndrome Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system. B vitamins - Effect on Energy Thiamine (B1) - Essential in the process of energy production. This vitamin also removes lactic acid from muscles, which causes them to be sore in fibromyalgia patients. Riboflavin (B2) - Riboflavin (vitamin B2) is crucial in the production of body energy. Supports healthy gluthathione reductase activity, which helps maintain gluthathione, a major protector against free radical damage. Vitamin B2 itself also has antioxidant qualities. Niacinamide(B3) - Essential vitamin that is a component of the body’s energy furnace, helping to improve fatigue and “brain fog”. Pantothenic Acid (B5) - This vitamin improves adrenal gland function, which will boost energy levels. It can also aid in weight loss by decreasing appetite. Vitamin B6 - Working along with thiamine, this vitamin is critical in the process of energy production. Vitamin B12 - Important for brain function and nerve repair. Aids in relieving fatigue symptoms in CFS patients. Folic Acid - Aids in strengthening the immune system, and aids in mental clarity and concentration. Q. What other supplements can help me with CFS? A. Many people with CFS/FMS are suffering from adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress like that seen in cases of CFS. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress. The good news is that changes in our hormone levels can return to normal when stress is decreased. However, in cases of CFS that return to normal can be made much simpler by using a glandular therapy regimen to ensure healthy cortisol levels and adrenal function. Glandular therapy uses the concentrated forms of bovine (cow) or porcine (pig) glands to improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacks and thus repairing the malfunctioning gland. Adrenal Extract If CFS has left your adrenal glands in a stressed-out state, you should see great results by taking adrenal supplements. Be sure to buy an adrenal extract supplement that contains both whole adrenal and adrenal cortex extracts. The best adrenal supplement should also contain vitamin C, vitamin B6, L-tyrosine, betaine, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients. The Road to Recovery-Adequate Sleep Disordered sleep is the underlying process that drives many of the symptoms of CFS/FMS. The most effective way to eliminate pain in CFS/FMS is to get seven to nine hours of deep sleep each night. However, getting adequate sleep is easier said than done for CFS sufferers with underlying fibromyalgia symptoms. The muscle knots of fibromyalgia make it uncomfortable to lie in one position for an extended time, causing difficulty in returning to deep sleep. Because of this, people with CFS/FMS do not stay in deep stages of sleep to recharge their “batteries.” In addition, poor sleep can cause and be caused by the suppression of the hypothalamus gland, which causes the brain to think it is daytime instead of night time. It may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Therefore, it is important to look for an herbal sleep formula that is especially formulated for people with CFS/FMS. The combination of herbs is important as each herb addresses a different aspect of sleeplessness and muscle tension. Ingredients - Effect on Sleep Wild Lettuce - Has been found to have sedative effects. Hops - Acts as mild sedative and has a sleep-inducing effect. Jamaica Dogwood Has been found to be mildly sedative and is often used for anxiousness. L-Theanine - Causes significant increases of neurotransimitter concentrations in the brain, which promotes muscle relaxion and improves sleep. Valerian - This herb has been clinically studied for its ability to improve sleep quality. Passionflower - This herb eases nervousness and insomnia. Putting It All Together After a good night’s rest, a powdered energy drink mix formulated for people with CFS/FMS should be drunk along with a well-balanced breakfast as discussed earlier. In addition to the nutritional beverage mix, a vitamin B complex supplement designed specifically for CFS sufferers, also discussed earlier, containing niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients, to combat your overwhelming fatigue, pain, and “brain fog.” Taking a daily adrenal supplement, like the one discussed earlier, will provide the much-needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy. Together, these four interventions: sleep formula; morning energy drink; energy B complex supplement; and an adrenal complex- can make an incredible difference that you should begin to notice within 2-3 weeks of starting this program. Conclusion Chronic fatigue syndrome and fibromyalgia are complex physical diseases with physical causes. The unrelenting symptoms of fatigue, pain, and mental fogginess can be overwhelming and frightening. Partnering with a healthcare practitioner specializing in CFS and utilizing different medical treatments, supportive therapies, and lifestyle changes are healthy ways to combat chronic fatigue syndrome. And taking nutritional supplements formulated specifically for people with CMS/FMS that help boost energy or help you get a good night’s sleep can give you critical control over the outcome of your illness and set you on the road to recovery.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1475) HDL Booster - Boost your good cholesterol
Date:
March 16, 2006 12:51 PM
HDL BOOSTER
(Product No. 02922)
DESCRIPTION:
HDL Booster is a physician-developed dietary supplement that has been clinically shown to increase good cholesterol levels, particularly HDL-2, the best form of cholesterol.* The formula combines essential vitamins and minerals, at levels recommended by the American Heart Association (AHA), with key amino acids, powerful antioxidants, and traditional herbal extracts to provide superior support for cardiovascular health.*
HDL Booster:
· Formulated by Dr. Dennis Goodman, Chief of Cardiology at
· Clinically studied to increase good cholesterol levels up to 23%*1
· All-inclusive formula; includes ingredients recommended in accordance with the American Heart Association
· Replaces the CoQ10 depleted by cholesterol lowering (statin) drugs.*2
STRUCTURE/FUNCTION:
HDL Booster has been clinically shown to increase HDL cholesterol levels.* HDL Booster also supports healthy cholesterol and healthy triglyceride levels already within the normal ranges.* By reducing C-reactive protein levels, HDL Booster helps support the body’s natural anti-inflammatory response.*
FORMULA:
Two tablets (one serving) contain:
Vitamin C (ascorbic acid) 148 mg
Vitamin E (as natural mixed tocopherols) 35 IU
Niacin (as niacinamide) 21 mg
Vitamin B6 (as pyridoxine HCl) 3 mg
Folic Acid 301 mcg
Vitamin B12 (as cyanocobalamin) 20 mcg
Magnesium (from magnesium amino acid chelate) 10 mg
Selenium (as L-selenomethionine) 49 mcg
Proprietary Blend 388 mg
hawthorn (Crategus oxyacantha) berry extract,
taurine, garlic (Allium sativum) bulb, grape seed (Vitis
vinifera) extract, grape skin (Vitis vinifera) extract,
N-acetyl-L-cysteine, alpha-lipoic acid, soy (Glycine
max) isoflavones, tocotrienols
L-Arginine (as L-arginine HCl) 153 mg
L-Carnitine (as L-carnitine L-tartrate) 51 mg
Coenzyme Q10 (CoQ10)(ubiquinone 10) 25 mg
Policosanol 7 mg
Other ingredients: See label for most current information.
Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives. This product contains natural ingredients; color variations are normal.
INTRODUCTION:
Cholesterol, the soft, waxy substance present among the lipids (fats) in the bloodstream and in all cells, is important for wide variety of physiological functions. It is essential for the formation of cellular membranes, necessary for the production of bile salts, and also plays a role in the synthesis of certain hormones.3-5
Cholesterol is both produced by the body and obtained from food. Endogenous cholesterol is formed by human cells, particularly liver cells, whereas exogenous cholesterol is absorbed through the gastrointestinal tract from food.3,4
Because cholesterol can not be metabolized for energy, it must be removed from the body once it has served its function. The major route of removal is through the liver, where it is processed and subsequently excreted from the body.3,4
Types of Cholesterol
Cholesterol is lipophilic (“fat loving” or water insoluble) by nature. It can not be dissolved in the blood, and must, therefore, be transported by carriers known as lipoproteins. These carriers are classified by density, with LDL (low density lipoproteins) and HDL (high density lipoproteins) being the most common.4,5
LDL is often referred to as “bad” cholesterol. LDLs carry cholesterol throughout the body. Conversely, HDL, or “good” cholesterol, is responsible for carrying cholesterol away from the arteries to the liver where it is eventually processed and eliminated from the body.3,4,6
Scientific studies have shown that both types of cholesterol are important indicators of cardiovascular health. But recent research, focusing on the beneficial subtypes of HDL, has found that certain fractions of HDL may be more supportive of cardiovascular health than others. The two most notably supportive HDL fractions are HDL-2 and HDL-3.7
The smaller HDL-3 is synthesized by the liver and intestines. This form, which is known as “free cholesterol-rich” HDL, scavenges or “scoops up” free cholesterol. The cholesterol is then chemically altered by the addition of an ester group. When sufficient cholesterol is esterified, HDL-3 becomes HDL-2, which is therefore referred to as “cholesterol ester-rich” HDL. HDL-2 is larger in size and has been shown to be more cardiosupportive than HDL-3.*7
HOW IT WORKS:
HDL is known to possess antioxidant activity and to help balance the body’s natural anti-inflammatory response, both of which are important for cardiovascular health, but its most important function is the role it plays in cholesterol transport.6,8 High levels of HDL cholesterol are also associated with reduced platelet activity, another key indicator of arterial and venous health.9
Both HDL and LDL levels are important indicators of healthy cardiovascular function.* Therefore, supplements that increase the level of good cholesterol can profoundly impact heart health.* In 2002, an open label pilot study was conducted at
The following chart summarizes the benefits of each of the ingredients in HDL Booster:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1238) Metaboplex
Date:
January 07, 2006 01:06 PM
Metaboplex: A high potency complex of pure trans-ferulic acid, Glycine and L-tyrosine, key daytime metabolic enhancing constituents. The result is a scientifically engineered dietary adjunct to support cut and definition objectives when traning and dieting to burn fat, without sacrificing hard earned muscle.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1177) Is there a cure for chronic fatigue syndrome?
Date:
December 10, 2005 03:19 PM
A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study (of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’. An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient. Medical Treatments Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for the pain, sleep disturbances’ digestive problems such as nausea, depression and anxiety, and flu-like symptoms. However, medications have not been universally successful because they tend to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems. Supportive Treatments People with CFS? FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness. Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage. Daily Nutritional Supplementation for Energy Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula: Vitamins, Minerals & Other Key Ingredients Vitamin A: Essentail for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone grown and healthy reproductive processes. Vitamin A in the form of beta-catotene is an antioxidant and free radical fighter. Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep. Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine. Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutrophils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier. Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain. Inositol: Enhances immune function by increasing natural killer cells. Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism. Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation. Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for production of energy in the body. Also essential for brain function. Zinc: Supports the immune system by enhancing neutrophil activity and supporting healthy antigen-antibody binding. Selenium: Supports immune function by enhancing antibody production. Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora. All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness. B Vitamin Complex for Energy In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B^, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. IT is also important to make sure that the dosages are high enough for CFS/FMS needs. B Vitamins Effect on Chronic Fatigue Syndrome Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1009) TMG Fact Sheet
Date:
December 07, 2005 02:13 PM
TMG Fact SheetNeil E. Levin, CCN, DANLA 03/07/05LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a Glycine atom. It can “donate” methyl groups. MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine. TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals. Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot. ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid. TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures. DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably. SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed. COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES: General: Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. Review. PMID: 15321791 Methylation: Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review]. Benson R, Crowell B, Hill B, et al. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res 1993;18:325–30. Chambers ST. Betaines: their significance for bacteria and the renal tract. Clin Sci 1995;88:25-7 [review]. Charlton CG, Crowell B Jr. Parkinson’s disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423–31. Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61. Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5. Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review]. Homocysteine: Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. Review. PMID: 15218538 Gahl WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis 1988;11:291-8. Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. PMID: 14652361 Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203 Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002 Nov;76(5):961-7. PMID: 12399266 Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review]. van Guldener C, Janssen MJ, de Meer K, et al. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J Intern Med 1999;245:175-83. Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50. Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria—the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53. Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985 Dec;34(12):1115-21. PMID: 3934499 Liver function: Babucke G, Sarre B. Clinical experience with betain citrate. Med Klin 1973;68:1109-13 [in German]. Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2. Barak AJ, Beckenhauer HC, Matti J, Tuma DJ. Dietary betaine promotes generation of hepatic S-adenosylmethioine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 1993;17:552-5. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329 Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated Glycine derivatives betaine, dimethylGlycine and sarcosine. Pharmacol Biochem Behav. 1985 Apr;22(4):641-3. PMID: 2581277 Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. Vet Hum Toxicol 1998;40:263-6. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488-99. PMID: 12730887 Kettunen H, Tiihonen K, Peuranen S, Saarinen MT, Remus JC. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69. PMID: 11691612 Kim SK, Kim YC, Kim YC. Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem Toxicol 1998;36:655-61. McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses. 2000 Sep;55(3):189-94. PMID: 10985907 Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 1998;44:249-55. Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc. 2004 Feb;63(1):65-71. Review. PMID: 15070439 Semmler F. Treatment of liver diseases, especially of fatty liver with betaine citrate. Ther Ggw 1977;116:2113-24 [in German]. Zapadniuk VI, Panteleimonova TN. [Cholagogic effect of trimethylGlycine in normal animals of different ages and in experimental atherosclerosis] Biull Eksp Biol Med. 1987 Jul;104(7):30-2. Russian. PMID: 3620644 Autism & Seizures: Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1. Roach ES, Carlin L. N,N-dimethylGlycine for epilepsy. N Engl J Med. 1982;307:1081-82. Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6. Immunity: Reap EA, Lawson JW. Stimulation of the immune response by dimethylGlycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6. Safety: Hoorn AJ. DimethylGlycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 Apr;222(4):343-50. PMID: 2468082
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=988) Benefits of Total Daily Formula
Date:
October 13, 2005 04:45 PM
Benefits of Total Daily Formula All fruits and vegetables contain carotenes, the plant pigments responsible for the rich variety of colors we enjoy in the natural world. Beta carotene is the most familiar member of the carotene family. But beta carotene never exists by itself; it is always found with other carotenes in foods. We need more than just beta carotene alone. Carotenes are powerful antioxidants, which means they help reduce the body's free radical burden. Research suggests that carotenes work as a team to keep us healthy.5 Total Daily Formula provides beta carotene, alpha carotene, lutein, lycopene, zeaxanthin and cryptoxanthin from natural sources such as algal extracts, carrot oil, marigold and tomatoes (Caromix®). Total Daily Formula uses only corn-free vitamin C (ascorbic acid). The full daily intake of 6 tablets provides an exceptionally generous 800 mg of vitamin C. Total Daily Formula supplies ample amounts of all essential B vitamins. Vitamin B3 is given as niacin plus an extra helping of niacinamide, the non-flush form of this important vitamin. The body uses pantothenic acid (vitamin B5) to deal with stress, so the formula provides 150 mg, which is 15 times the RDA. Vitamin B6 is another B vitamin people may run short of, so 60 mg -- 30 times the RDA -- is supplied. The formula contains 800 mcg of folic acid, the vitamin now recognized by the FDA as essential for prevention of neural tube defects in unborn babies. Folic acid also helps prevent accumulation in the body of homocysteine, a metabolite of the amino acid methionine.6 A high blood homocysteine level is now considered to be a risk factor for heart disease.7 Flavonoids, also known as "bioflavonoids." are plant pigments widely distributed throughout the plant kingdom.8 Previously known as "Vitamin P," because they help reduce capillary permeability (leakiness) flavonoids are now regarded as "semi-essential" non-vitamin nutrients that benefit health in a variety of ways.9 In addition to maintaining the structure of blood vessels, flavonoids function as versatile antioxidants. Flavonoids protect vitamin C from destruction by free-radicals, helping to preserve the body's vitamin C supply.10 Total Daily Formula provides 100 mg of pure flavonoids from 112 mg of citrus extract. Three superior sources of Calcium Total Daily Formula contains three of the best absorbed and most effective forms of calcium available. MCHC (microcrystalline hydroxyapatite concentrate) is a naturally-derived compound composed of calcium, plus all the minerals and organic factors in living bone tissue. MCHC has been clinically shown to benefit bone health.11 Calcium citrate malate is a very well-absorbed form of supplemental calcium shown in recent research to be helpful for postmenopausal women.12,13 Calcium glycinate is chelated with the amino acid Glycine, one of the most efficient mineral carriers for effective absorption.14,15 Magnesium is essential for strong bones and healthy hearts. This versatile mineral also regulates nerve function, keeps muscles relaxed and coordinates activity of over 300 enzymes in the body.16 Total Daily Formula contains 100 percent magnesium glycinate for exceptional absorption and gentleness on the intestinal tract.17 Magnesium glycinate has been clinically tested on people with severe malabsorption with excellent results.18 Total Daily Formula provides - in addition to zinc, chromium, selenium and iodine - vanadium and molybdenum. Vanadium helps maintain normal blood sugar.19 Molybdenum works as a co-factor for enzymes that help detoxify and eliminate foreign substances from the body.20 Bioperine® for Enhanced Absorption Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. 21 Betaine HCL - supplies HCL (hydrochloric acid) to assist digestion. All natural tablet coating made of vegetable concentrate and beta carotene.
Scientific References 2. Morgan, K.J. et. al. Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition. 1985;4:195-206. 3. Lakschmanan, F.L., Rao, R.B., Kim, W.W., Kelsay, J.L. Magnesium intakes, balances and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 1984;40:1380-89. 4. Mertz, W. The Essential Trace Elements. Fed. Proc. 1970;29:1482. 5. Perry, G. Byers, T. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu. Rev. Nutr. 1992;12:139-59. 6. Landgren, F., et. al. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Int Med 1995;237:381-88. 7. Clarke, R., et. al. Hyperhomocysteinemia: an independent risk factor for vascular disease. New Eng J Med 1991;324:1149-55. 8. Havsteen, B. Flavonoids, a class of natural compounds of high pharmacological potency. Biochemical Pharmacology 32(7):1141-48. 9. Middleton, E. The flavonoids. TIPS 1984; 5:335-38. 10. Roger, C.R. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 44(9):725-804. 11. Dixon, A. St. J. Non-hormonal treatment of osteoporosis. British Medical Journal 1983;286(6370):999-1000. 12. Smith, K.T. et. al. Calcium Absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351-352. 13. Dawson-Hughes, B. et. al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New England Journal of Medicine 1990 Sep 27;323(13):878-883. 14. Albion Research Notes Vol. 4, No. 1, ©Albion Laboratories Jan,1995. 15. Ashmead, H.D. Intestinal Absorption of Metal Ions and Chelate, Springfield: Charles C Thomas, ©1985. 16. Wester, P.O., Dyckner, T. The importance of the magnesium ion. Magnesium deficiency-symptomatology and occurrence. Acta Med Scand 1992; (Suppl) 661:3-4. 17. Albion Research Notes Vol. 3, No. 1, ©Albion Laboratories, Feb 1994. 18. Schutte, S., et. al. Bioavailability of Mg diglycinate vs MgO in patients with ileal resections. Abstract 115, AJCN 1992;56(4). 19. Cohen, N. et. al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J. Clin Invest 1995; 95:2501-09. 20. Sardesi, V.M. Molybdenum: An essential trace mineral element. Nutr Clin Pract 1993; 8:277-81. 21. Bioperine® - Nature's Bioavailability Enhancing Thermo-nutrient. Executive Summary' 1996; Sabinsa Corporation, Piscataway, N.J.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=839) Comprehensive Prostate Formula-the Clinical Studies
Date:
October 13, 2005 04:32 PM
Helps maintain a healthy prostate gland. Supports normal urinary function. Comprehensive Prostate Formula-the Clinical Studies Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved. The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.11,12,13 For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months.1 The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as effective as therapy for the prostate. The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT.14 Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells.15 The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions.14,16 These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. Clinical studies have used extracts containing 85 to 90 percent fatty acids and sterols. Like Saw palmetto, Pygeum contains natural sterols and fatty acids.2 Although the mechanisms for its effect have not been clearly established, animal experiments suggest Pygeum may work by inhibiting prostate cell proliferation and reducing inflammation.17,18 In several European trials, Pygeum has successfully improved urinary function. In a large double-blind, placebo-controlled study, 263 men were given 100 mg of Pygeum extract a day for 60 days. Urination improved in 66 percent of the men taking Pygeum, compared with 31 percent on placebo, based on subjective and objective tests.19 Nettles are approved by the German Commission E as effective for relieving inflammation in the urinary tract.20 As far back as 1950, German investigators have observed favorable effects on the prostate with the use of Nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals. In a recent double blind study published in the journal Clinical Therapeutics, 134 men took a combination of Nettle root extract and Pygeum extract over a period of 56 days.3 Urination was significantly improved. L-Alanine, Glutamic Acid and Glycine As noted above, Drs. Feinblatt and Gant discovered that a combination of the amino acids L-alanine, glutamic acid and Glycine has a positive effect on prostate-related urinary function.5 A controlled study of 45 men was conducted to follow up on these initial observations.21 The majority of subjects experienced complete or partial relief in urinary complaints such as nighttime urination and urgency.
Scientific References 2. Lawrence Review of Natural Products. Pygeum. Jan 1998. Facts and Comparisons, St. Louis, MO. 3. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses Clinical Therapeutics 1993; 15(6):1011-19. 4. Wagner, H., Willer, F., Samtleben, R., Boos, G. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots Phytomedicine 1994; 1:213-224. 5. Feinblatt, H.M., Gant, J.D. Palliative treatment of benign prostatic hypertrophy. Journal of the Maine Medical Association, March 1958:99-124. 6. Giovanni, E., et. al. Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 1995;87(23):1767-76. 7. Wallace, A.M., Grant, J.K. Effect of zinc on androgen metabolism in the human hyperplastic prostate. Biochemical Society Transactions 1975; 3(3):540-42 8. Badmaev, V., Majeed, M., Passwater, R. Selenium: A quest for better understanding. Alternative Therapies 1996; 2(4):59-67. 9. Fouhad, M.T. Selenium and cancer, chromium and diabetes: two trace elements that have merits as dietary supplements in human nutrition. Journal of Applied Nutrition 1979:31(1&2):14-17. 10. Vescovi, P.P., et. al. Pyridoxine (Vit. B6) decreases opoids-induced hyperprolactinemia. Horm. metabol. Res. 1985; 17:46-47. 11. Tasca, A., et. al. Treatment of obstructive symptomatology caused by prostatic adenoma with an extract of Serenoa repens. Double-blind clinical study vs. placebo. Minerva Urologica e Nefrologica 1985; 37:87-91. 12. Champault, G., Bonnard, A.M., Cauquil, J., Patel, J.C. Medical treatment of prostatic adenoma. A controlled test of PA 109 vs. placebo in 110 patients. Ann. Urol. 1984; 18(6):407-410. 13. Crimi, A., Russo, A. The use of Serenoa repens extract in the treatment of functional disturbances caused by prostate hypertrophy. Med. Praxis 1983; 4:47-51. 14. NiederprŸm, H.J., Schweikert. H.U., ZŠnker, K.S. Testosterone 5 alpha-reductase inhibition by free fatty acids from Sabal serrulata fruits. Phytomedicine 1994; 1:127-133. 15. Sultan, C., et. al. Inhibition of androgen metabolism and binding of liposterolic extract of Serenoa repens B in human foreskin fibroblasts. J. Steroid Biochem. 1984; 20(1):515-519. 16. Weissner, H., et. al. Effects of the Sabal serrulata extract IDS 9 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasia. The Prostate 1996;28:300-06. 17. Yablonsky, F. Nicolas, V., Riffaud, J.P., Bellamy, F. Antiproliferative effect of Pygeum africanum on rat prostatic fibroblasts. J. of Urology 1997; 157:2381-87. 18. Marconi, M. et. al. Anti-inflammatory action of Pygeum extract in the rat. Farmaci. & Terapia. 1986; 3:135. 19. Barlet, A, et. al. Efficacy of Pygeum africanum extract in the treatment of micturational disorders due to benign prostatic hyperplasia. Evaluation of objective and subjective parameters. A multicenter, randomized, double-blind trial. Wien. Klin. Wocheschr. 1990; 22:667-73. 20. The Complete German Commission E Monographs. 1998, Blumenthal, M., ed., (p.216) Austin, TX: American Botanical Council. 21. Damrau, F. Benign prostatic hypertrophy: amino acid therapy for symptomatic relief. American Journal of Geriatrics 1962; 10:426-30.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=838)
Date:
October 06, 2005 10:08 PM
Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance [1]. Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium [2]. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake [3]. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds. An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" [4]. The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups [5]. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium [6]. In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body [7]. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys [8]. Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium [9]. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium. Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 [10]. The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA. Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements. Magnesium-the Versatile Mineral The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes." Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP [11]. ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds". Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles [12]. Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat [13]. Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress [14]. This has been found true even in the absence of an actual magnesium deficit in the body. Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density [15]. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men [16]. In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency [17]. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly. Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes [18]. A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure. Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption [19]. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide [20]. Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 [21]. Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® [22]. Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J. *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Doctor's Best•1120 Calle Cordillera•Suite 101, San Clemente, CA 92673
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=777) HAWAIIAN NONI (Morinda citrifolia)
Date:
July 11, 2005 08:50 PM
INTRODUCTION In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:
Genus Rubiaceae Common Names Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni. Parts Used The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions. Physical Description Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic. Chemical Constituents Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.
FLOWER
FRUIT
discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer. ROOT AND ROOT BARK
Pharmacology Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells. Body Systems Targeted The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties. Satety Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended. Suggested Uses Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit . NONI: ITS USE AND HISTORY Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent . Wonder Herb of Island Folk Healers Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking. Noni’s Medical Reputation Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine. A Timely Reemer gence Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals. TRADITIONAL USES OF NONI Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15 decoctions to stimulate delayed menst ruation.
XERONINE: THE SECRET OF NONI? One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit . Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18 NONI PROCESSING How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production. MODERN APPLICATIONS OF NONI Overview Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure. Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis. xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion. Cancer A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21 In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells. Arthritis with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration. Immune System The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus. The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions. Antioxidant The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available. Diabetes While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes. Pain Killer A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29 Skin Healing Agent One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine. burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30 Drug Addiction The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions. Complementary Agents of Noni
PrimaryApplications of Noni
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Date:
June 24, 2005 05:15 PM
Today’s sedentary lifestyles and sugar-rich, nutrient-poor foods are contributing to the rise of obesity in our society. The result: challenges to your body’s system of balancing blood sugar levels and insulin activity. Maintaining a healthy diet and lifestyle helps keep blood sugar levels in the normal range, but sometimes you need nutritional support when you don’t have time to make those healthy food choices. Source Naturals, the science company, introduces VANADIUMW/CHROMIUM for blood sugar support. Research shows that these two important minerals help maintain normal blood sugar levels when used as part of your diet. Vanadium works together with chromium to support healthy blood sugar levels. Research has shown that both of these important minerals play a key role in normal insulin function. Vanadium: Balances Insulin Activity Vanadium, named after Vanadis the Norse goddess of beauty, belongs to a group of biologically important metals known as transition elements. These metals have a natural tendency to form complexes with organic compounds called coordination compounds that serve important biological functions. Insulin is secreted by the pancreas in response to high blood glucose levels after meals. Without insulin, glucose cannot enter cells to provide fuel for cellular energy. The sugar that remains in the blood can create problems by binding with protein molecules, resulting in damaged, non-functioning structures, in a process called glycation. Some evidence suggests that vanadium supports these vital metabolic processes because of its ability to mimic the actions of insulin. More Absorbable Form of Vanadium Absorption of dietary vanadium and supplemental vanadium is poor. It is estimated that less than 5% of dietary vanadium is absorbed. Organic forms of vanadium, such as bis-glycinato oxovanadium or BGOV, are recognized as being more absorbable. BGOV is an organically bound, bioavailable form of vanadium complexed with the amino acid Glycine. Glycine, an amino acid found in the protein of all life forms, generates superior vanadium absorption. Chromium: Supports Glucose Metabolism Chromium is a trace element the body needs in very small amounts, but it plays a significant role in human nutrition. Its most important function is to help regulate the amount of glucose in the blood. Insulin plays a role in this process, by regulating the movement of glucose out of the blood and into the cells. Chromium is a key constituent of the compound known as glucose tolerance factor (GTF). This mineral enhances the effectiveness of insulin, encouraging glucose to enter cells, where it can be burned for fuel. Chromium participates in glucose metabolism by enhancing the effects of insulin. Insulin binds to insulin receptors on the surface of cells, activating those receptors and stimulating glucose uptake by cells. Through its interaction with insulin receptors, insulin provides cells with glucose for energy and prevents blood glucose levels from becoming elevated. Glucose buildup in the bloodstream is associated with adverse changes in lipid profiles and increased challenges for cardiovascular health. Some studies examining the effects of chromium supplementation on lipid profiles have observed reduction in serum total cholesterol, LDL cholesterol, and triglyceride levels. Source Naturals VANADIUM W/CHROMIUM includes ChromeMate®, a patented compound of chromium and niacin with proven GTF activity. Wellness Nutrition Taking responsibility for your health is at the heart of the wellness revolution. Sometimes life may seem like it’s passing you by and you may not have time to focus on staying healthy. Your local health food outlet is a great resource for nutritional education and effective, advanced natural products. Source Naturals is pleased to partner with these outlets to bring you products like VANADIUM W/CHROMIUM to help you maintain a healthy balance. References: Anderson, R.1998. Chromium, glucose intolerance and diabetes. Journal of the American College of Nutrition 17(6):548-555. Jellin, J., et al. 2004. Vanadium Monograph. Pharmacists Letter/Prescribers Letter Natural Medicines Comprehensive Database. Therapeutic Research Facility. Nandhini, S., et al. 1993. Insulin-like effects of bis-glycinato oxovanadium complex on experimental diabetic rats. Indian Journal of Biochemistry and Biophysics 30:73-76.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=420) Enhancer for Youthful Vitality
Date:
June 16, 2005 08:20 PM
NEW PRODUCT ANNOUNCEMENT Enhancer for Youthful Vitality
Five tablets contain: Suggested Use: 5 tablets before exercise and/or at bedtime with plenty of water at least two hours after the last meal. Discontinue use or reduce dosage if any of the following symptoms are present: nausea, excessive salivation, vomiting, diarrhea, muscle spasms, cramps, excessive urination, insomnia, headache, cardiac arrhythmias, high blood pressure, or changes in mood or emotional balance.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=369) Prostate Health Naturally
Date:
June 16, 2005 11:11 AM
VitaNet ® LLC. Discount Vitamin Store.
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Healthful supplements
There are many deodorants in the market but Lavilin is among the reputed deodorants. It is a gentle and effective deodorant.
Gelatin is a protein, made from the hydrolysis of collagen, a protein that makes up about a third of all mammalian tissue proteins and the connective tissues of the body. Collagen makes up the tendons of the body muscles. Gelatin powder is gelatine that has been dried and broken up into individual grains, which has the advantage of dispersing more easily throughout a dish.
We all know that vitamins and other nutrients are essential for a healthy life and if we lack any of these nutrients or vitamins we consume it by supplement. However, most of us do not know that many other substances are also there that work like vitamins, but they are different from Vitamin and TMG or TrimethylGlycine is one of these substances that help your body work effectively.
Chamomile is a short low growing herb with small fine-leaves and daisy like flowers. The herb's flowers have a small-yellow center which is surrounded by thin white-petals. The Chamomile leaves have a sweet-apple smell, The herb thrives in warm-humid conditions and it has a tendency to becoming invasive if its left to just grow freely.
Glutathione is a simple protein that consists of three amino acids. These amino acids include glutamic acid, cysteine, and Glycine. Due to the chemical nature of sulphur-containing cysteine, glutathione is able to effortlessly donate electrons. This ability is the reason why it has powerful antioxidant properties. Intracellular glutathione status is a sensitive indicator of cellular health and of the cell’s ability to resist toxic challenges. 
Planetary Herbals is pleased to introduce full spectrum lomatium, a botanical used traditionally by Native Americans for centuries to support immune and respiratory health. 
