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Why magnesium may be the single most important nutrient you need totake for heart health Darrell Miller 4/26/19
The common causes of candida overgrowth Darrell Miller 1/22/19
6 Steps to Get Your Cortisol Levels Under Control & Turn Down the Stress Darrell Miller 7/27/18
If Your Heel Hurts When You Wake Up, This Is Happening To Your Body! Darrell Miller 6/2/17
A brain wide chemical signal that enhances memory Darrell Miller 1/30/17
Red meat link to common bowel disease: study Darrell Miller 1/20/17
Trilobites: Your Liver Doesn’t Know It’s the Holidays Darrell Miller 12/31/16
Can You Get Too Much Protein? Darrell Miller 12/12/16
Five ways to avoid germs while traveling Darrell Miller 12/6/16
Benefits of stress management Darrell Miller 11/30/16
Are You Gaining Weight For No Reason? Check Your Thyroid Darrell Miller 10/31/16
How to Detoxify the Body Darrell Miller 1/27/16
How Huperzine Helps With Memory Darrell Miller 7/30/15
How Does Malic Acid Help With Fibromyalgia? Darrell Miller 8/22/11
Protect The Liver with Glutathione And Cysteine Darrell Miller 4/23/09
Kaneka QH - Ubiquinol Darrell Miller 11/30/07
7-Keto - Anti-Aging and Antioxidant Protection Darrell Miller 12/18/05
THERAPEUTIC APPLICATIONS OF ST. JOHN’S WORT DEPRESSION—AN OVERVIEW Darrell Miller 7/15/05
Summary of Specific Actions Associated with Ginkgo Darrell Miller 6/25/05
Smell Perception, Hearing and Ginkgo Darrell Miller 6/25/05
CANCER TREATMENT AND PREVENTION WITH GARLIC Darrell Miller 6/25/05
Menopause: Disease or Condition? Darrell Miller 6/13/05
Breast Cancer Darrell Miller 6/10/05
PYCNOGENOL ® - The Ultimate Antioxidant Darrell Miller 6/4/05
PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ... Darrell Miller 6/4/05
Re: Acetyl-L-Carnitine - Anti-Aging Brain Nutrient ... Darrell Miller 5/31/05




Why magnesium may be the single most important nutrient you need totake for heart health
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Date: April 26, 2019 10:20 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Why magnesium may be the single most important nutrient you need totake for heart health





Magnesium deficiency, which afflicts close to 50 percent of the U.S. population, can have a profoundly negative impact on your health. Failure to consume enough magnesium can increase insulin resistance and create a higher risk of cardiac disease. A Medical University of South Carolina (MUSC) study found that magnesium-deficient people had substantially higher levels of harmful C-Reactive Proteins — associated with inflammation and heightened risk of heart disease— present in their blood. A second MUSC study confirmed this association while also noting that magnesium supplements could help reduce the health impacts of not getting enough magnesium from dietary sources.

Key Takeaways:

  • It has been discovered that the most vital nutrient for supporting cardiovascular health is magnesium but many American adults are lacking in it.
  • When magnesium is found in your body at low levels, you can build up insulin resistance which brings up the possibility of type 2 diabetes.
  • A real connection between magnesium deficiency and a protein, C-reactive protein (CRP) have been found and C-reactive protein can trigger acute inflammations.

"If you do not have enough magnesium in your body, you can become more prone to various diseases and disorders."

Read more: https://www.naturalnews.com/2019-03-11-magnesium-may-be-the-single-most-important-nutrient-for-heart-health.html

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The common causes of candida overgrowth
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Date: January 22, 2019 04:39 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The common causes of candida overgrowth





Candida albicans is a form of yeast that is present in small colonies across the human body. Unfortunately, when these clusters grow to an abnormal size, the heightened populations can cause some serious health concerns such as mouth ulcers, gastrointestinal issues, and even psychological symptoms. Researchers are now finding links between the overgrowth of Candida albicans and potential triggers such as: fermented foods like pickles, contraceptives, the overuse of antibiotics, and several other contributing factors.

Key Takeaways:

  • Candida albicans is common in the human body but common signs of candidiasis or candida overgrowth include bloating, diarrhea, fatigue, flatulence, and joint pain.
  • Contraceptives or birth control pills, and intrauterine devices can kill good bacteria and encourage the growth of yeast in the human body.
  • Although fermented foods like kimchi, pickles and sauerkraut, are good for the gut bacteria, they can also encourage candida overgrowth so it is wise to eliminate them.

"However, when candida populations swell into an overgrowth, you can develop severe health problems."

Read more: https://www.naturalnews.com/2018-12-25-the-common-causes-of-candida-overgrowth.html

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6 Steps to Get Your Cortisol Levels Under Control & Turn Down the Stress
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Date: July 27, 2018 02:44 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 6 Steps to Get Your Cortisol Levels Under Control & Turn Down the Stress





6 Steps to Get Your Cortisol Levels Under Control & Turn Down the Stress

Cortisol is a hormone that is released whenever we are under intense levels of stress. Whenever you are in a situation that causes extreme tension, your brain reacts with what is called a, "fight or flight" response. This response is what contributes to heightened cortisol levels. Elevated cortisol can lead to various health conditions, so it is important to keep it regulated by consuming an anti-inflammatory diet, and by participating in activities that reduce stress such as meditation.

Key Takeaways:

  • To keep your cortisol levels low, switch to a diet that is low in processed foods and high in nutrients, antioxidants, and fiber.
  • Relieve stress with techniques such as meditation, deep breathing exercises, acupuncture, and spending time with nature.
  • Be sure to exercise regularly and get enough sleep to keep your hormones in balance.

"Although most think of cortisol as a bad thing — such as contributing to acne, weight gain or high blood pressure — there’s actually a lot more to cortisol levels than just our stress response and its unwanted symptoms."

Read more: https://draxe.com/cortisol-levels/

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If Your Heel Hurts When You Wake Up, This Is Happening To Your Body!
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Date: June 02, 2017 05:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: If Your Heel Hurts When You Wake Up, This Is Happening To Your Body!





The calcaneal spur affects the heel and has a similar feelings of walking on nails and is very unpleasant. This feeling which is normally heightened in the morning, can happen if you are in one position too long, wear high heels, or overload the foot with weight. luckily, surgical intervention is rare and shoe insoles are a common and effective remedy along with gentle stimulating massages. If you wish to treat your foot there are some cost effective and natural remedies such as coconut oil, apple cider vinegar, ice pack and sodium bicarbonate.

https://www.youtube.com/watch?v=m5JKuc5axGI&rel=0

Key Takeaways:

  • A spur, located in the tendon region of the foot, causes a lot of pain, besides impeding daily activities.
  • This problem, often the result of high heels, worn by women, can potentially be addressed with natural treatments of coconut oil and apple cider vinegar.
  • Other interventions include insoles, massage treatments, ice packs and, less often, surgery.

"This malady is usually caused by taking inappropriate positions for a long time, or by wearing inappropriate footwear."

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4750)


A brain wide chemical signal that enhances memory
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Date: January 30, 2017 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A brain wide chemical signal that enhances memory





Alzheimer’s seems to become more prevalent every day. This has lead to much research into what causes it and how to prevent it. While we still do not know the exact mechanism behind what causes it, there has been some discovery on ways to help fight the disease. A recent study has shown that keeping our brains active will help fend off the signs of mental decline. This discovery was uncovered in light of drugs that seem to help with the disease when they activate acetylcholine release and activate the brain for longer periods of time.

Key Takeaways:

  • How does heightened attention improve our mental capacity?
  • A chemical signal released across the brain is a response to attention demanding or arousing situations.
  • Current drugs used in the treatment of Alzheimer's, designed to boost this chemical signal, counter the symptoms of dementia.

""Many current and future drug therapies for a wide range of brain disorders including Alzheimer's and schizophrenia are designed to target chemical systems such as acetylcholine""



Reference:

https://www.google.com/url?rct=j&sa=t&url=https://www.sciencedaily.com/releases/2017/01/170124140842.htm&ct=ga&cd=CAIyGjFmZmViMTExOGM5Mzg5YTQ6Y29tOmVuOlVT&usg=AFQjCNGZkjbk4NRk0qkoHWDs8xryfJHAnQ

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3851)


Red meat link to common bowel disease: study
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Date: January 20, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Red meat link to common bowel disease: study





Watch out if your on a rich red meat diet! Studies show people on red meat rich diets have been linked to a heightened risk of a bowel inflammation called diverticulitis. Diverticulitis is a common condition in which small pockets lining the intestine become irritated. Diverticulitis causes 200,000 hospital admissions every year in the United States alone.

Key Takeaways:

  • Researchers have determined connections between the consumption of red meat and an intestinal illness called diverticulitis.
  • Several behaviors, including low-fiber diets, smoking, obesity, and the use of anti-inflammatory drugs, have also been linked to diverticulitis.
  • Research found that even after controlling for other factors, diverticulitis increased among men in the study group who consumed more red meat.

"Diverticulitis is a common condition which occurs when small pockets lining the intestine -- called diverticula -- become irritated."



Reference:

https://www.yahoo.com/news/red-meat-common-bowel-disease-study-001338853.html?ref=gs

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Trilobites: Your Liver Doesn’t Know It’s the Holidays
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Date: December 31, 2016 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Trilobites: Your Liver Doesn’t Know It’s the Holidays





The study included 89,000 middle-aged men and women who were followed for up to 13 years. At study entry 68 percent of the men and 11 percent of the women were regular drinkers. The analysis was confided to the men because the number of female drinkers was so small. The investigators found that men who drank relatively heavily on most days of the week had a heightened risk of dying from any cause. In contrast, men who drank roughly the same amount alcohol each week, but drank less frequently, showed no increase in their mortality risk. The findings, which appear in the American Journal of Epidemiology, give some credibility to the widespread social belief in Japan that a "liver holiday," a few days off from drinking each week helps counter the ill effects of alcohol.

Key Takeaways:

  • If you’re experiencing indigestion or your energy levels are low after too many holiday parties, your liver could be out of sync.
  • Over the holidays, many of us will drink, stay up past bedtime, eat an extra slice of pie and sleep in. Fun as they are, these activities can tamper with our circadian rhythms, the feedback loops that sync our body’s functions to our external environment.
  • Circadian rhythms are important for helping the liver anticipate the body’s demands throughout the day, like stockpiling energy after meals and releasing it when we sleep.

"To keep your liver’s clock consistent this holiday season, avoid extreme behaviors"



Reference:

//www.nytimes.com/2016/12/22/health/your-liver-doesnt-know-its-the-holidays.html?partner=rss&emc=rss&_r=0

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3722)


Can You Get Too Much Protein?
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Date: December 12, 2016 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Can You Get Too Much Protein?





Excessive protein can have a stimulating effect on an important biochemical pathway called the mammalian target of rapamycin. This pathway has an important and significant role in many cancers. When you reduce protein to just what your body needs, mTOR remains inhibited, which helps minimize your chances of cancer growth. Additionally, when you consume too much protein, your body must remove more nitrogen waste products from your blood, which stresses your kidneys. Chronic dehydration can result, as was found in a study involving endurance athletes.

Key Takeaways:

  • some researchers worry that the muscle building properties that consumers seek in protein may be a double-edged sword, perhaps even leading to an increased risk of cancer
  • The vast majority of Americans already get more than the recommended daily amounts of protein from food
  • Large population studies also suggest an association between habitual high protein intake and a heightened risk of diabetes

"Protein has achieved a venerated status in the dietary world for everything from building muscle to preventing weight gain. But can you get too much of a good thing?"



Reference:

//www.nytimes.com/2016/12/06/well/eat/can-you-get-too-much-protein.html?partner=rss&emc=rss&_r=0

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Five ways to avoid germs while traveling
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Date: December 06, 2016 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Five ways to avoid germs while traveling





Different areas of the world have different germs and it is easy to pick up a germ you are not resistant to already. No one wants to get sick when they travel and ruin their vacation or business trip. This article will explain five different ways to avoid picking up new germs while you travel.

Key Takeaways:

  • "The risk of contracting a contagious illness is heightened when we travel within any enclosed space, especially during the winter months, when most of the respiratory viruses thrive," Gendreau said.
  • Studies show that germs can travel easily on an airplane, where people are packed together like sardines.
  • For example, a woman on a 1994 flight from Chicago to Honolulu transmitted drug-resistant tuberculosis to at least six of her fellow passengers, according to a New England Journal of Medicine study.

"Gendreau studies germiness while traveling, and he knows just how infectious travel can be."



Reference:

//www.cnn.com/2016/11/18/health/avoid-germs-while-traveling/index.html?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcnn_health+%28RSS%3A+CNN+-+Health%29

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Benefits of stress management
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Date: November 30, 2016 01:53 AM
Author: Darrell Miller
Subject: Benefits of stress management

Mental Health can be overlooked in our everyday lives but it plays a huge role in our health. Our mental state can affect us in many ways both positively and negatively. This article will be discuss the importance of Mental Health with a concentration on stress management. Stress is a significant cause of mental illness today and although we can't eradicate it, we can manage it It is important to understand that not all stress is negative. Stress may occur prior to weddings, graduations, or even social gatherings, but no matter the source of stress, your bodies respond the same. Also, some stress is good for you in order to manage skills needed for survival such as fight or flight.

Experts suggest a combination of physical, social, environmental, and psychological approaches to managing stress. When we are stressed, we encounter General Adaptation Syndrome (GAS). GAS is your complex physiological responses that happen as a result of the stress and has three phases. The first phase of GAS is the alarm phase. The alarm phase occurs when we sense there is a stressor present (Body doesn't sense whether it is a good or bad stressor), everything becomes heightened and hormones respond. The seconds phase of GAS is called the resistance phase. During the resistance phase your body resists stress to get your it back to homeostasis. If you can't rid the stress you move into exhaustion The last phase, exhaustion, occurs when your body is tired and can't fight anymore to get it back to homeostasis. Physical or emotional tension is often a good indicator of stress.


Below is a short list of symptoms from stress.

  • Tension and irritability
  • Fear and anxiety about the future
  • Difficulty making decisions
  • Being numb to one's feelings
  • Loss of interest in normal activities
  • Loss of appetite

We all experience some level of stress on a regular basis but as I mentioned before, too much can be harmful to your body. Below I have listed ways in which you can deal with and reduce stress levels.

Take Care of Yourself


Taking care of yourself seems self-explanatory for many but as we enter the exhaustion phase our attention to self-care begins to decline. Eat a healthy diet, get plenty of sleep, treat yourself, and maintain your normal routine.

Stay Active


It is often said that exercise is the most underused stress reliever and this is 100% true. Working out forces you to take your mind off of the stressors and focus on what you are doing and nothing else. Get in a gym or go for a run to lower your stress levels.

Social Support


Being able to talk to someone during stressful times is very important. Connect with a friend or family member that you will listen to what you want to get off your mind. This can be very helpful for stress reduction.

Avoid Alcohol or Drugs


People often turn to drugs and alcohol in times of stress but fail to realize they only provide temporary relief. Once your "high" or "buzz" wears off, you will more than likely feel worse than before. Alcohol and drugs add to stress and do not help to reduce its impact. I hope this information helps you to recognize when you are stressed and how to handle it Stress is a serious issue that we tend to overlook. Stress is usually a catalyst for other illnesses such as anxiety to occur.

In conclusion chamomile will help you zap stress and unwind and have healthy life.


(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3535)


Are You Gaining Weight For No Reason? Check Your Thyroid
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Date: October 31, 2016 11:47 PM
Author: Darrell Miller
Subject: Are You Gaining Weight For No Reason? Check Your Thyroid

The human body is an extremely complex system of checks and balances that's held in a very delicate state of equilibrium. It's hard to understand at times but with the patience of science, we can usually get to the bottom of whichever mysteries our bodies will present us with.

One of the mysteries that some people might find themselves faced with at some point in their lives is that of gaining weight for no reason. Diets and exercise will seem not to work. A possible culprit might be found in a small organ known as the thyroid gland. Let’s have a closer look at it and how it may be affecting your metabolism and weight.


How the Thyroid Gland Works

The thyroid is the largest gland in your endocrine system of glands and is located right in the middle of your neck just below the Adam’s apple in men. Endocrine glands refer to glands that secrete hormones in the human body. The thyroid gland produces the hormones Thyroxine and Triiodothyronine, which are referred to as the thyroid hormones. These hormones play a significant role in your energy regulation and metabolism functions by prompting almost every cell in your body to increase its activity. This is essentially what your metabolic rate is. There are three basic categories of problems that can occur in your thyroid gland, as follow:

  • Hypothyroidism or Underactivity – too little thyroid hormones produced
  • Hyperthyroidism or Overactivity – too much thyroid hormones produced
  • Growths – include benign cysts and nodules as well as cancers of the thyroid gland

The Thyroid Gland and Weight Gain

When too little thyroid hormone is being produced in a patient, their metabolic rate will slow down, meaning that the body’s cell will not be burning up calories at their optimum rate. This will lead to these unspent calories being deposited throughout the body in the form of fat. The person affected might find themselves suddenly gaining weight without any apparent changes in their lifestyle or eating habits. This is also why dieting and exercise may not have the desired effect on the patient.

The symptoms of an underactive thyroid can be very vague because the hormone acts throughout the body but should you find yourself experiencing some of these, consider testing specifically for hypothyroidism:

  • General weakness
  • Cold intolerance
  • Heightened cholesterol levels
  • Fatigue
  • Sleepiness
  • Constipation
  • Mood swings
  • Forgetfulness
  • Heavy menses
  • Coarse, dry hair and skin
  • Weight gain
  • Changes in blood pressure
  • Depression and/or irritability
  • Muscle cramps and aches
  • Swelling in legs (edema)
  • Blurred vision
  • Hoarse voice and sore throat
  • Hair loss (on head and/or body)


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How to Detoxify the Body
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Date: January 27, 2016 08:46 PM
Author: Darrell Miller
Subject: How to Detoxify the Body

Free radicals are elements in the body that attacks healthy cells, resulting to cellular and tissue damage. When this happens, mild conditions such as weight gain to serious illnesses such as cancer may occur. The production of more and more free radicals intensifies due to several factors. Pollution, the food you eat, different kinds of chemicals found in the environment and the daily stress you go through are all factors that contribute to the increase of free radicals. Thus, detoxification should be a must for everybody.

Detox means cleansing the body of toxins and harmful elements. The importance of detoxification has intensified as years go by. The modern world has not only offered outstanding innovations but many deadly diseases. The many benefits of detox can help counter these unhealthy occurrences.


What are some of the Benefits of Detoxifying the Body?

  • Energy boosts

This is among the exciting benefits one can get from detoxification. Just like a clean house or a clean car engine, you would feel a heightened vitality as harmful elements are flushed out of your system. This boosts in energy will help you accomplish daily tasks and even go to the gym after work.

  • Healthier organs

Detoxification cleanses essential organs such as the liver, kidneys and colon. These organs are crucial in the body’s waste management system. Buildup of toxins in the body can slow down the work that they do. Overtime, when the stress is too much to bear, these organs may experience fatigue, disrupting their function. Diseases associated with abnormally functioning liver and kidneys can become serious medical conditions. Therefore, proper care and management is important.

  • Weight loss

Weight loss can just be a bonus when you choose to detox. Because you are choosing to live healthily, you can rid yourself of excessive calories, salt, sugar and other unhealthy foods that compromises your detoxification process. Also, as you continue with a good cleansing regimen, your organs will be able to function well, improving your metabolism.


How Can You Detoxify?

The “father of plants”, Alfalfa, is gaining popularity in the field of detox. Alfalfa has roots that can reach 20 to 30ft down the ground. For this unique characteristic, minerals and essential vitamins are rich in Alfalfa. Traditionally, the herb’s parts from its leaves to the seeds are used as medicine. It is a good source of minerals such as Calcium, Iron, Potassium, Phosphorous and Zinc, as well as vitamins A, C and E.

Alfalfa


Alfalfa, as early as the 6th century, has been beneficial for its role in treating many health issues such as kidney problems, arthritis, cardiovascular disorders, digestive problems and auto-immune illnesses. Today, more and more health problems are being addressed by the use of Alfalfa. Detoxification using the herb also became popular due to its natural ability to eliminate excess fluid and toxins in the body. Aside from this, its vitamins and mineral properties are useful for people who are trying to lose weight.

Detoxification should be a healthy process. Make sure to make it as one by using the right detox ingredient.


References

https://bestofmotherearth2012.wordpress.com/2009/01/13/detox-with-alfalfa/

//www.drugs.com/npc/alfalfa.html

//www.webmd.com/vitamins-supplements/ingredientmono-19-alfalfa.aspx?

//www.homeremediesweb.com/alfalfa_health_benefits.php


632651520011

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How Huperzine Helps With Memory
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Date: July 30, 2015 04:00 PM
Author: Darrell Miller
Subject: How Huperzine Helps With Memory

Memory refers to the process by which information is encoded, stored and retrieved when required.  Encoding makes information from the outside world to be sensed in form of physical and chemical stimuli.  In the first stage, information has to be changed in order to be put into the encoding process.  Storage is the process by which the information is maintained over duration of time.  The third of final stage is the retrieval process where the information stored is returned back to the consciousness.

Brain

One of the major problems that many people undergo is memory loss.  This is a condition in which a person cannot recall information or events that they would be able to remember in normal circumstances.  One of the most effective ways to help improve memory is by taking Huperzine.  This is a drug that has proven to help boost memory and learning.

Here are some of the ways on how Huperzine help with memory:

1. Boost the level of acetylcholine

Acetylcholine is a very important transmitter in the brain responsible for carrying out several functions including those associated to memory and cognition. It is released into the space between two cells, where it then stimulates nerve impulses from one cell to the other. When acetylcholine fails to work effectively, several types of brain dysfunction occurs. A shortage of acetylcholine is known to be the common cause of memory loss, decreased intelligence and learning ability. Huperzine helps in reducing the breakdown of acetylcholine and boost the duration and strength of nerve impulse. It makes the neurotransmitter more available leading to better memory and improved overall brain functioning.

2. Protection against free radicals

Huperzine offers protection against free radicals that are known to be the major cause of modern diseases. It decreases the activity of heightened free radical activity in the brain. This goes a long way in reducing the risk of having memory loss. It has also proved to be effective in helping adolescents improve their learning abilities and memories.

References:

//www.smart-publications.com/articles/huperzine-a-the-proven-therapeutic-treatment-for-memory-loss

Read More

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How Does Malic Acid Help With Fibromyalgia?
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Date: August 22, 2011 12:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Malic Acid Help With Fibromyalgia?

Solaray - Malic Acid with Magnesium 90ct 133mgFibromyalgia(FM) is a condition affecting primarily middle-aged women and is often misdiagnosed and misunderstood as an ailment which has a diverse set of symptoms, in which none are pleasant. It basically is a medical disorder defined by chronic and widespread pain, a heightened response to pressure and often time painful as well. No one really knows what the exact causes are. There are a number of studies taking place and done by reputable medical organisations (such as the Nation Institute of Arthritis and Musculoskeletal and Skin Diseases - NIAMS) which are geared towards the establishment, once and for all, of the route cause of Fibromyalgia. A part of the current scientific theories is the inherent genetic factor, but even in this it seems that geneticists are not clear as to which genes exactly may be the culprit. What has been concretely established and clarified though is that not just because your mom or dad has it you’ll have it. Stress in some studies has also been found as a contributor but may not be the main cause though.

Malic acid is an organic compound and also a carboxylic diacid and is an active ingredient in many sour or tart foods. It is mostly in unripe fruits and it has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally. The salts and esters of this diacid are called malates. The malate anion is an intermediate in the citric acid cycle. However it was not until 1785 that Carl Wilhelm Scheele first isolated it from apple juice. It is formed in metabolic cycles within the cells of plants animals and humans. A somewhat large amount of Malic Acid is produced and broken down in the body each day. Malic acid also provides stamina and endurance within the muscle cells. It is particularly useful in the blocking of aluminum toxics, which has been found to possibly be one contributing factors to fibromyalgia.

Energy Production

Compelling evidence has surfaced that malic acid may plays a central role in energy production, especially during hypoxic conditions. In some experiments that have been done, the improvement that came about when malic acid was administered to the subject was gone after discontinuing for 48 hours. The theory behind this is in the relative association of hypoxia to FM, if it will improve hypoxic conditions then it will be beneficial for FM sufferers as well just as Chronic Fatigue Syndrome has also been associated with FM. Additionally, many hypoxia related conditions, like respiratory and circulatory insufficiency, are related to deficiency in energy production as well. Therefore, malic acid may be of benefit in these conditions.

The mitochondria are the energy furnaces in cells which metabolize food for energy. Some findings suggest that this structure does not operate efficiently in those with FM. So, for the mitochondria to produce ample amounts of ATP, several nutrients are essential and Malic Acid is one of them. Imbalances in the mitochondria’s process can cause the body to switch from oxygen-based metabolism to the less efficient anaerobic metabolism and this would contribute to an abnormal buildup of lactic acid following even light exertion. This lactic acid buildup results in fatigue, weakness, pain and muscle spasms.

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Protect The Liver with Glutathione And Cysteine
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Date: April 23, 2009 01:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Protect The Liver with Glutathione And Cysteine

The tripeptide L-glutathione is synthesized in the body from L. glutamic acid, L-cysteine and glycine, a reaction that can occur in any cell of the body although it is essential that it also occurs in the liver. Should glutathione concentrations drop, they can be increased by supplementing with cysteine or any other of the three amino acids that are used in the biosynthesis of this important if substance

The tripeptide exists in two forms: the reduced form (GSH) which contains a sulfhydryl (SH) functional group attached to the cysteinyl part of the molecule, and the oxidized form glutathione disulfide (GSSG). As electrons are lost from the reduced form, two molecules combine to create a dimer formed by a disulfide bridge, the process which can be reversed through reduction of the GSSG. Such electrons are lost during its reaction with free radicals, in which the free radicals are neutralized by the donation of an electron from the oxidized version of glutathione.

The definition of a free radical is a molecule that is lacking one electron from an electronic pair. Its prime purpose is then to steal an electron from the nearest molecule to it. In doing so, it can not only destroy that molecule, but also destroy body cells and lead, not only to premature aging, but also to some potentially fatal conditions.

It is an unusual peptide in that it involves a link between the cysteine amino grouping and the carboxyl functional group of the glutamic acid. It is a powerful antioxidant, acting as an effective free radical scavenger and protecting the body cells from the effects of free radical oxidation. However, it is on its detoxification effect in the liver that we shall focus here prior to discussing some other uses to which the body puts glutathione in its two manifestations.

Much of the detoxification is connected with the thiol group in the molecule. Take mercury for example. The thiol grouping forms a strong Hg-sulfydryl chemical bond within the liver, in the form of a glutathione-mercury chelate. In this form mercury is unable to exert any toxic effect on the body and can be excreted in the normal manner. The same reactive pathway is followed by other heavy metals that can bond to thiol groupings. In this way L-glutathione can protect the liver from the effects of a number of toxic heavy metals such as cadmium and chromium.

This is an important property of the amino acid, particularly in industrial and urban environments where the population is more prone to exposure to heavy metals than their rural counterparts. However, the end result on the glutathione is that it is removed from the body, and, particularly with city dwellers, a supplement may be required to maintain a healthy concentration of this amino acid in the body and in particular in the liver. Therefore, although L-glutathione is not considered an essential amino acid, in that it is biosynthesized within the body, a supplement is sometimes required, particularly by those who live in large cities.

It is important to consider the form in which the glutathione supplement is administered. This is because of the presence of gamma-glutamyltranspeptidase within the digestive system. This enzyme appears to destroy L-glutathione before it can be absorbed in the intestine so normal oral forms of supplementation are likely to be ineffective. Possible forms of effective administration include buccal (between the cheek and teeth) and hypodermically.

An alternative means of supplementation is to take substances such as selenium, methionine, alpha-lipoic acid, vitamin C and glutamine that stimulate the biosynthesis of glutathione. Also, since the substance utilizes the raw materials of L-cysteine, glutamic acid and glycine in its intracellular production, supplementation with these amino acids should also help to produce L-glutathione.

That said, let's return to its antioxidant properties and its effect on the liver that contains the largest stocks of glutathione in the body. It is generally regarded as the most important antioxidant in the body. It protects cellular cytoplasm from oxidation by reducing disulfide groups and maintaining a highly reducing environment within the cytoplasm. It reacts with hydrogen peroxide and other oxidative agents, and is converted to the oxidized form GSSG. It is then reduced back to GSH through the combination of the reducing agent and an enzyme. The reducing agent is nicotinamide adenine dinucleotide phosphate (NADPH), the enzyme being glutathione reductase.

The implications that this strong reducing effect has on the liver are significant. Reduced GSH L-glutathione levels have been found in patients suffering from HIV, hepatitis C and other liver diseases. Supplementation with GSH has been found to restore normal levels of glutathione to the liver, and it has been demonstrated that the treatment has improved such conditions significantly.

Atherosclerosis is a condition of the arteries caused by the deposition of plaques formed from oxidized low-density lipoproteins, otherwise known as bad cholesterol. The strong antioxidant effect of GSH prevents this from LDLs from being oxidized and deposited on the arterial wall. There are other results of glutathione supplementation that indicate the effectiveness of antioxidants in the treatment of serious liver conditions, and there are no doubts that combating the effects of free radicals and oxidizing agents within the liver has a positive effect on many potentially serious liver diseases.

Many of these are exacerbated by the generation of free radicals by relatively modern pollution sources such as pesticides, petrol and diesel emissions, tobacco fumes and various other chemical emissions. A strong antioxidant such as L-glutathione cannot be anything other than an effective means of reducing the biological effect of these oxidants. It protects not only the liver but also the lungs and cardiovascular system.

For all these reasons a supplement consisting of L-glutathione or its constituent parts, glutamic acid, cysteine and glycine, provide significant protection against the stresses and strains of modern living. Increased pollution levels and heightened oxidative stress levels within the body are playing havoc with our body defenses, and GSH is an important one of them that can easily be enhanced by supplementation. There are no known reactions to L-glutathione supplementation, but pregnant women and babies should receive expert medical advice prior to taking it.

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Kaneka QH - Ubiquinol
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Date: November 30, 2007 03:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Kaneka QH - Ubiquinol

UBIQUINOL COQH

CoQ10 with Heightened Absorption

 

• New, active form of CoQ10 with heightened absorption, which results in increased blood serum levels

• Provides powerful antioxidant support by blocking free radical damage within cell membranes.

• Supports cardiovascular health and energy production by aiding the synthesis of mitochondrial ATP.

• Supports normal, healthy liver functioning by reducing oxidative stress.

 

Source Naturals Offers a New, Premier CoQ10 Product

 

UBIQUINOL COQH bundles all the great benefits of the powerful antioxidant CoQ10 into a superior form that enhances absorption into the body and increases blood serum levels. UBIQUINOL COQH facilitates the production of cellular energy in the mitochondria, which in turn provides robust support to some of the body’s most demanding systems. Both the cardiovascular and liver systems rely heavily on CoQ10 to help generate the energy needed for healthy functioning. Also found in high levels within cellular membranes, CoQ10 works as an effective antioxidant that protects the integrity of mitochondrial and lipid membranes.

 

1 softgel contains:

 

Kaneka QH™ Ubiquinol 100 mg


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7-Keto - Anti-Aging and Antioxidant Protection
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Date: December 18, 2005 09:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 7-Keto - Anti-Aging and Antioxidant Protection

7-Keto

“Anti-Aging and Antioxidant Protection”

The Fountain of Youth Discovered in Wisconsin

It turns out that Ponce de Leon was looking in the wrong place for the fabled Fountain of Youth. It was recently discovered – in Wisconsin! And it turns out that the Fountain of Youth isn’t really a fountain – it’s a biological compound produced in our own bodies. This compound is extremely important for the growth and development of the human body, and, as the body’s production of this substance decreases with age, the signs of aging begin to appear – weight gain, wrinkled skin, loss of muscle, loss of cognitive function, and loss of libido.

This biological Fountain of Youth was discovered by Dr. Henry Lardy and associates at the Institute for Enzyme Research at the University of Wisconsin. It’s called 7-Keto™, a metabolite of a hormone produced by the adrenal glands called DHEA (dehydroepiandrosterone). Research on 7-Keto™ indicates that it may work through a number of pathways to combat the signs of aging. Helping the body maintain a healthy weight as we age greatly improves overall health and longevity and is one of the strongest benefits discovered for 7-Keto™ to date.

Unfortunately, because 7-Keto™ is a metabolite of DHEA, whose levels decline as we age, so to does this wonderful, natural bio-nutrient. Scientists originally looked to DHEA for improved cardiovascular vitality, and strengthened immune and brain function3. Researchers believed that declining DHEA so profoundly impacted our bodies that it could be partly responsible for the effects of aging. They hypothesized that supplementation with DHEA could sustain hormone levels and stave off many of the degenerative changes we collectively call aging. But there was a catch. Because DHEA is converted into sex hormones, people taking supplemental DHEA would sometimes experience the frightening, unwanted side effects associated with hormone supplementation.

In 1989, Dr. Lardy and his colleagues set out to solve the mystery of eliminating DHEA’s side effects by examining all of the constituents that make up DHEA. Ten long years of research unearthed hundreds of DHEA derivatives, which were developed and tested continuously, until one derivative rose above all the others – a metabolite that was incredibly bio-active and far more promising than any other substance they’d tested. That metabolite is 7-Keto™. 7-Keto™ outperformed DHEA and other metabolites in immune modulation, memory enhancement and thermogenesis and, more importantly, without any adverse side effects3.

The most significant benefit of 7-Keto™ supplementation is its ability to support healthy body weight. Obesity is a major contributing factor in a number of serious medical conditions. A recent study assessed the effectiveness of 7-Keto™ on weight loss and body fat loss. Participants were divided into two groups; one group received 100mg of 7-Keto™ twice daily and the other a placebo. Both groups exercised three times per week. At the end of the study, researchers noted a statistically significant reduction in body weight and body fat only in the 7-Keto™ group. Researchers concluded that 7-Keto™ was three times more effective than diet and exercise alone in promoting weight and fat loss1,2,7. Preliminary research also indicates that 7-Keto™ may support healthy immune and nervous systems. One study measured the effects of 7-Keto™ on memory function. Subjects were given a single dose of a substance that inhibits nerve cell communication and causes shortterm memory loss. Afterwards subjects were given a single dose of 7-Keto™. Results showed that 7-Keto completely reversed the memory impairment, suggesting that 7-Keto™ supports memory retention6.

Another study gauged 7-Keto™’s ability to support immune system function. Interleukin 2 (IL2) is a substance produced by T lymphocytes that causes an increase of disease fighting white blood cells. White blood cells were taken from healthy volunteers and introduced into a solution that contained 7-Keto™ for 24 hours. When the cultures were tested for heightened IL2 production. 7-Keto™ was shown to augment IL2 production by a statistically significant 68%4.

NOW® 7-Keto™ is a well-researched and patented form of this amazing product that’s supplied by the Humanetics Corporation. Humanetics 7-Keto™ has been proven safe and well-tolerated in doses up to 200mg5. Research is clear, the rate at which we age can be influenced by the diet and lifestyle choices we make. One very smart choice would clearly be adding NOW 7-Keto™ to your diet.

References

1) 7-Keto™: The Key to Healthy Aging – Scientific Support; Humanetics Corporation, 1999
2) Garbis, Spiro; 7-Keto™ DHEA; internal meta-analysis, 2000
3) Sahelian, Ray, M.D.; DHEA: A Practical Guide; Avery Publishing, 1996
4) Lardy, H. et.al. Dehydroepiandrosterone and 7-Keto™ DHEA Augment Interleukin 2 (IL2) Production by Human Lymphocytes In Vitro, 5th Conference on Retroviruses and Opportunistic Infections, February 1-5, 1998, Chicago, IL
5) Davidson, M.H. et. al. Clinical Safety and Endocrine Effects of 7-Keto™ DHEA; Presented at Experimental Biology 98 (Conference), April 19-22, 1998, San Francisco, CA
6) Shi, J. et. al. The Effect of 7-oxo- DHEA acetate on memory in young and old C57BL/6 mice; Steroids 65 (2000); 124-129
7) Colker, C. et. al. Double-Blind, Placebo-Controlled, Randomized Clinical Trial Evaluating the Effects of Exercise Plus 3-Acetyl- 7-oxo-dehydroepiandrosterone on Body Composition and the Endocrine System in Overweight Adults; Journal of Exercise Physiology online; Vol. 2, No. 4, October, 1999



--
buy 7 Keto at Vitanet ®

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THERAPEUTIC APPLICATIONS OF ST. JOHN’S WORT DEPRESSION—AN OVERVIEW
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Date: July 15, 2005 09:12 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: THERAPEUTIC APPLICATIONS OF ST. JOHN’S WORT DEPRESSION—AN OVERVIEW

THERAPEUTIC APPLICATIONS OF ST. JOHN’S WORT DEPRESSION—AN OVERVIEW

Depression is a disorder that affects millions of people, both Americans and worldwide. It takes many forms, but is usually marked by sadness, inactivity and heightened selfdepreciation. Hopelessness and pessimism are often common symptoms, as are lowered self-esteem, reduced energy and vitality, and loss of the overall capability to enjoy one’s existence.

Depression is probably the most common psychiatric complaint offered to doctors, and has been described by physicians from at least the time of Hippocrates, who called it “melancholia.” The course the disorder runs varies widely from person to person. Depression may be short-term, or may occur repeatedly at short intervals. It may be somewhat permanent, mild or sever, acute or chronic. And who does depression most affect? Rates of incidence are higher among women than men (for varying reasons, some not totally understood). And men are more at risk of suffering from depression as they age, while a woman’s peak age for experi-encing depression is usually between the ages of 35-45.

Depression is caused by many things—it could come about because of childhood traumas, or because of stressful life events—but more and more, doctors and scientists are pointing to biochemical processes as a main culprit in the onset of depression. Defective regulation of the release of one or more naturally occurring monoamines in the brain—particularly norepinephrine—leads to reduced quantities or reduced activity of these chemicals in the brain, bringing on the depressed mood for most sufferers. Accompanying the increase in depression cases and the emerging knowledge of its causes has been the rise of drug and other therapies in treating the disorder. The two most important are drug therapy and psychotherapy. Psychotherapy aims to resolve any underlying psychic conflicts that may be causing the depressed state, while giving emotional support to the patient. This usually involves seeing a psychiatrist and/or psychologist at regular intervals. This also may be accompanied by participation in support groups.

Antidepressant drugs, on the other hand, directly affect the chemistry of the brain and its chemicals, such as the monoamines that are thought to have the most effect on depressed emotional states and moods. The tricyclic antidepressant drugs are thought to work by inhibiting the body’s physiological inactivation of the monoamine transmitters. This results in the buildup or accumulation of these neurotransmitters in the brain and allows them to remain in contact with nerve cell receptors longer, thus aiding in elevating the mood of the patient. There are other drugs, called oxidase inhibitors, which interfere with the activity of monoamine oxidase, an enzyme known to be involved in the breakdown of norepinephrine and serotonin.5

While drug therapy is something more favorable than continuing suffering from depression, for many persons who take these medications it brings on very undesirable side effects. Uncomfortable physical side effects are among the biggest complaints. Many drug users suffer from sensations of nausea, bloating, indigestion, abdominal cramping and diarrhea, and other gastrointestinal discomforts. Dizziness is often a common complaint, and there are many others. For decades, St. John’s wort has been utilized as a mood elevator, antidepressant and overall mental stimulant. As mentioned before, since times as far back as the Crusades do we have record of St. John’s wort being used in this and other capacities. Wounds were treated with the herb’s extracted oil, the insane were given the herb for its effect on both the nervous system and brain, and it was even used to cast out evil spirits (which often is linked to hallucinations and other mental instability).

More recent uses in “folk” or nonstandard medicine point to St. John’s wort’s effective use not only as an antidepressant and nervous system tonic, but also for neuralgia, wounds, kidney problems, its anti-inflammatory and antibacterial properties, and of very recent interest, its use as an AIDS virus inhibitor. Michael Murray, in his book Natural Alternatives to Over-the-Counter Drugs, points to St. John’s wort’s uses for the previously listed uses, and the results of several recent clinical studies. Rebecca Flynn and Mark Roest also outline very well the benefits of the herb as shown in medical and other tests.6 The information coming from both the folk medicine and the clinical medicine worlds indicates that St. John’s wort possesses effective and safe healing properties for several disorders and ailments, and potentially many more.

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Summary of Specific Actions Associated with Ginkgo
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Date: June 25, 2005 12:39 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Summary of Specific Actions Associated with Ginkgo

Summary of Specific Actions Associated with Ginkgo

  • • Improves blood circulation and oxygenation of brain cells, which boosts brain function and helps to treat disorders such as senile dementia, some types of depression and Alzheimer’s disease.
  • • In stimulating brain cell oxygenation, may significantly improve mental clarity and alertness.
  • • Strengthens the vascular system, which helps decrease the risk of blood clots, therefore lessening the probability of strokes. • Tissue oxidation and nutrient transport are enhanced, there by contributing to the treatment of any vascular disease such as tinnitus in the ear and any macular generation in the eye, as well as leg pain due to arterial insufficiency. • May contribute to less organ rejection in the case of transplants by inhibiting a compound called PAF (platelet activating factor) which is involved in the rejection process. • Works as an anti-stress adaptogen herb in its ability to increase ATP at the cellular level, resulting in increased energy and heightened stamina.

    Unquestionably, ginkgo will continue to enjoy its current popularity. As baby boomers continue to enlarge the senior citize n block of our population, supplements which have the ability to deter or even prevent age-related disorders will be vigorously sought after.

    Ginkgo can be used in these combinations for bioenhancement:

  • • ginkgo, ginseng, sage, bee pollen, and capsicum
  • • ginkgo, suma and gotu kola
  • • ginkgo and garlic
  • • ginkgo and butcher’s broom, centella, milk thistle and bilberry
  • • ginkgo and vitamin B complex, magnesium, and choline

    Ginkgo: Primary Applications

    The following are general areas that ginkgo biloba can be used effectively:

  • • Alzherimer’s Disease
  • • Antioxidant
  • • Attention Span
  • • Blood Clots
  • • Brain Booster
  • • Cardiovascular Problems
  • • Cerebrovascular Insufficiency
  • • Circulatory Disorders
  • • Dementia
  • • Dizziness
  • • Edema
  • • Hypoxia
  • • Inflammation
  • • Impotence
  • • Ischemia
  • • Longevity
  • • Memory Loss
  • • Multiple Sclerosis
  • • Muscular Degeneration
  • • PMS
  • • Raynaud’s Disease
  • • Senility
  • • Stress
  • • Stroke
  • • Tinnitus
  • • Vascular Disease

    Secondary Applications

    The following are areas of secondary application for ginkgo biloba:

  • • Allergies
  • • Angina
  • • Anxiety
  • • Arthritis
  • • Asthma
  • • Bronchial Infections
  • • Cancer
  • • Carpal Tunnel Syndrome
  • • Cough
  • • Depression
  • • Epilepsy
  • • Eye Problems
  • • Hemorrhoids
  • • High Blood Pressure
  • • Lung Conditions
  • • Migraines
  • • Toxic Shock Syndrome
  • • Transplant Rejection
  • • Urinary Tract Disorders
  • • Varicose Veins
  • • Vascular Impotence
  • • Vertigo

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    Smell Perception, Hearing and Ginkgo
    TopPreviousNext

    Date: June 25, 2005 12:00 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Smell Perception, Hearing and Ginkgo

    Smell Perception, Hearing and Ginkgo

    Over 200,000 visits to the doctor annually are due to lack of smell or the diminished ability to smell properly. In addition, an abnormally heightened sense of smell can also be a problem.

    Interestingly, these types of smell disorders are commonly seen in people suffering from Alzheimer’s disease or Parkinson’s disease. Both of these disorders are the result of faulty bio-chemical reactions in the brain. Ginkgo is one of the supplements that has been re p o rted to help smell perception. Effective dosages would depend on the degree of severity and the current nutritional status of the person. Ginkgo as a Treatment for Tinnit us When circulation is improved, frequently hearing does as well.

    Ginkgo helps to oxygenate tissues more effectively which can enhance nutrient transport to the nerves of the inner ear. As a result, conditions such as tinnitus (ringing in the ear) may be alleviated. Tinnitus is a very difficult condition to effectively treat. If the tinnitus is the result of a circulatory deficiency, ginkgo may be effective. The role of ginkgo as a viable therapy for the disord e r remains somewhat controversial.

    In terms of treating tinnitus with ginkgo, experimentation is the best approach. Tinnitus can be caused by a number of differe n t problems and the search for an effective treatment can only be made by the individual. In addition, treatment must be sustained for a long period of time before any judgement can be drawn. A minimum of two weeks is necessary. For more seve re cases of tinnitus, a longer period of therapy is required. German tests using ginkgo for sudden hearing loss suggested that in cases where hearing is lost for no apparent reason, ginkgo was effective in promoting a remission after one week of treatment. In some cases, hearing was also improved.11 One of the main advantages of using ginkgo over other drugs for hearing loss is that it is considered safe with minimal side effects.

    Deafness Due to Compromised Blood Flow

    In some cases of cochlear deafness, ginkgo has proven to be a valuable therapeutic agent. As in the case of tinnitus, treatment should be initiated and sustained.

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    CANCER TREATMENT AND PREVENTION WITH GARLIC
    TopPreviousNext

    Date: June 25, 2005 10:14 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: CANCER TREATMENT AND PREVENTION WITH GARLIC

    CANCER TREATMENT AND PREVENTION WITH GARLIC

    One of the most exciting aspects of the therapeutic value of garlic lies in its potential use as an anti-cancer agent. Several animal experiments have suggested that Garlic can inhibit or even reverse the growth of certain tumors.

    One in three people will develop cancer at some time during their life and one in five will die from it. Cancer ranks second only to heart disease as a leading cause of death in the United States. Projections put cancer as the number one killer of Americans sometime after the year 2000. While cancer research has spent millions of dollars searching for the elusive cure, thousands continue to die from cancer. Garlic has finally caught the attention of cancer research and is currently under scrutiny for its anti-carcinogenic properties.

    Several laboratory tests have found that certain enzymes contained in some cancers are totally inhibited by alliinase and other compounds contained in garlic. Several Japanese experiments suggest that injecting garlic into rats with certain types of sarcoma blocked tumor cell reproduction and caused mutations in the cancer cells themselves.38

    As is the case with other infectious diseases, garlic’s role in simulating the body’s immune defenses may also be linked to cancer control and prevention. Because garlic helps to mobilize the immune system, carcinogens which may initially begin tumor formation may be attacked and destroyed by heightened immune function. Because garlic enhances the action of the body’s natural killer cells, it boosts their ability to attack tumor cells before cancers can develop. In laboratory tests, the natural killer cells of garlic-eating subjects destroyed 159 percent more tumor cells than those who had not consumed garlic.39

    “In animal studies by Weisberger and Pensky of Western Reserve University, as reported in Science, mice injected with cancer cells died within 16 days. When cancer cells were treated with Garlic extract and injected into the animals, no deaths occurred for a period of 6 months. In other studies, feeding fresh Garlic to female mice completely inhibited the development of mammary tumors.”40

    Studies in cancer Research in the Journal of the National Cancer Institute reveal that stomach cancer risk was significantly reduced with the consumption of allium vegetables including garlic and scallions. The high germanium content of garlic may also play a role in cancer treatment and prevention. At this writing, continuing research unfolds on garlic and its effect on cancer cells. The National Cancer Institute is planning a study of garlic’s role as a cancer-preventing agent. The study was planned after reports indicated that people who live in China and Italy and eat a lot of garlic seem to enjoy a certain degree of protection against stomach cancer.

    Dr. William J. Blot of the Institute stated that these people eat a lot of garlic and related vegetable such as scallions and onions, a habit that correlates with a lower incidence of stomach cancer.41

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    Menopause: Disease or Condition?
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    Date: June 13, 2005 03:44 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Menopause: Disease or Condition?

    Menopause: Disease or Condition?

    by Mary Ann Mayo & Joseph L. Mayo, MD Energy Times, September 4, 1999

    It's front-page news. It's politically correct and socially acceptable. Talking about menopause is in. Suddenly it's cool to have hot flashes. Millions of women turning 50 in the next few years have catapulted the subject of menopause into high-definition prominence.

    It's about time. Rarely discussed openly by women (what did your mother ever advise you?), meno-pause until recently was dismissed as "a shutting down experience characterized by hot flashes and the end of periods." Disparaging and depressing words like shrivel, atrophy, mood swings and melancholia peppered the scant scientific menopausal literature.

    What a difference a few years and a very vocal, informed and assertive group of Baby Boomers make. Staggered by the burgeoning numbers of newly confrontational women who will not accept a scribbled prescription and a pat on the head as adequate treatment, health practitioners and researchers have been challenged to unravel, explain and deal with the challenges of menopause.

    Not An Overnight Sensation

    Menopause, researchers have discovered, is no simple, clear cut event in a woman's life. The "change of life" does not occur overnight. A woman's body may begin the transition toward menopause in her early 40s, even though her last period typically occurs around age 51. This evolutionary time before the final egg is released is called the perimenopause. Erratic monthly hormone levels produce unexpected and sometimes annoying sensations.

    Even as their bodies adjust to lower levels of estrogen, progesterone and testosterone, some women don't experience typical signs of menopause until after the final period. A fortunate one-third have few or no discomforts.

    Hormonal Events

    According to What Your Doctor May Not Tell You About Premenopause (Warner Books) by John R. Lee, MD, Jesse Hanley, MD, and Virginia Hopkins, "The steroid hormones are intimately related to each other, each one being made from another or turned back into another depending on the needs of the body...But the hormones themselves are just part of the picture. It takes very specific combinations of vitamins, minerals and enzymes to cause the transformation of one hormone into another and then help the cell carry out the hormone's message. If you are deficient in one of the important hormone-transforming substances such as vitamin B6 or magnesium, for example, that too can throw your hormones out of balance. Thyroid and insulin problems, toxins, bad food and environmental factors, medication and liver function affect nutrient and hormone balance."

    The most important reproductive hormones include:

    Estrogen: the female hormone produced by the ovaries from puberty through menopause to regulate the menstrual cycle and prepare the uterus for pregnancy. Manufacture drops significantly during menopause. Estradiol is a chemically active and efficient form of estrogen that binds to many tissues including the uterus, breasts, ovaries, brain and heart through specific estrogen receptors that allow it to enter those cells, stimulating many chemical reactions. Estriol and estrone are additional forms of estrogen.

    Progesterone: also produced by the ovaries, it causes tissues to grow and thicken, particularly during pregnancy, when it protects and nurtures the fetus. Secretion ceases during menopause.

    Testosterone: Women produce about one-twentieth of what men do, but require it to support sex drive. About half of all women quit secreting testosterone during menopause.

    Estrogen's Wide Reach

    Since estrogen alone influences more than 400 actions on the body, chiefly stimulating cell growth, the effects of its fluctuations can be far-reaching and extremely varied: hot (and cold) flashes, erratic periods, dry skin (including the vaginal area), unpredictable moods, fuzzy thinking, forgetfulness, fatigue, low libido, insomnia and joint and muscle pain.

    Young women may experience premature menopause, which can occur gradually, as a matter of course, or abruptly with hysterectomy (even when the ovaries remain) or as a result of chemotherapy. Under such conditions symptoms can be severe.

    In the 1940s doctors reasoned that if most discomforts were caused by diminishing estrogen (its interactive role with progesterone and testosterone were underestimated), replacing it would provide relief. When unchecked estrogen use resulted in high rates of uterine cancer, physicians quickly began adding progesterone to their estrogen regimens and the problem appeared solved.

    For the average woman, however, hormone replacement therapy (HRT) became suspect and controversial, especially when a link appeared between extended use of HRT (from five to 10 years) and an increase in breast and endometrial cancers (Journal of Clinical Pharmacology 37, 1997). The result: Women have drawn a line in the sand between themselves and their doctors.

    Resolving The Impasse

    Since hormone replacement reduces the risk of major maladies like heart disease, osteoporosis, Alzheimer's, colon cancer and diabetes that would otherwise significantly rise as reproductive hormone levels decrease, most doctors recommend hormone replacement shortly before or as soon as periods stop. Hormone replacement also alleviates the discomforts of menopause.

    But only half of all women fill their HRT prescriptions and, of those who do, half quit within a year. Some are simply indifferent to their heightened medical risks. Some are indeed aware but remain unconvinced of the safety of HRT. Others complain of side effects such as bloating, headaches or drowsiness.

    Women's resistance to wholesale HRT has challenged researchers to provide more secure protection from the diseases to which they become vulnerable during menopause, as well as its discomforts. If the conventional medical practitioners do not hear exactly what modern women want, the complementary medicine community does. Turning to centuries-old botanicals, they have validated and compounded them with new technology. Their effectiveness depends on various factors including the synergistic interaction of several herbs, specific preparation, the correct plant part and dosage, harvesting and manufacturing techniques.

    Research demonstrates that plant hormones (phytoestrogens) protect against stronger potentially carcinogenic forms of estrogen while safely providing a hormone effect. Other herbs act more like tonics, zipping up the body's overall function.

    Help From Herbs

    Clinical trials and scientific processing techniques have resulted in plant-based supplements like soy and other botanicals that replicate the form and function of a woman's own estrogen.

    The complementary community also can take credit for pushing the conventional medical community to look beyond estrogen to progesterone in postmenopausal health.

    Natural soy or Mexican yam derived progesterone is formulated by pharmacologists in creams or gels that prevent estrogen-induced overgrowth of the uterine lining (a factor in uterine cancer), protect against heart disease and osteoporosis and reduce hot flashes (Fertility and Sterility 69, 1998: 96-101).

    A quarter of the women who take the popularly prescribed synthetic progesterone report increased tension, fatigue and anxiety; natural versions have fewer side effects.

    These "quasi-medicines," as Tori Hudson, a leading naturopathic doctor and professor at the National College of Naturopathic Medicine, Portland, Oregon, calls them, are considered "stronger than a botanical but weaker than a medicine." (Hudson is author of Gynecology and Naturopathic Medicine: A Treatment Manual.)

    According to Hudson, the amount of estrogen and progesterone in these supplements is much less than medical hormone replacement but equally efficacious in relieving menopausal problems and protecting the heart and bones.

    According to a study led by Harry K. Genant, PhD, of the University of California, San Francisco, "low-dose" plant estrogen derived from soy and yam, supplemented with calcium, prevents bone loss without such side effects as increased vaginal bleeding and endometrial hypoplasia, abnormal uterine cell growth that could be a precursor to endometrial cancer (Archives of Internal Medicine 157, 1997: 2609-2615).

    These herbal products, including natural progesterone and estrogen in the form of the weaker estriol or estrone, may block the effect of the stronger and potentially DNA-damaging estradiol.

    Soy in its myriad dietary and supplemental forms provides a rich source of isoflavones and phytosterols, both known to supply a mild estrogenic effect that can stimulate repair of the vaginal walls (Journal of the National Cancer Institute 83, 1991: 541-46).

    To enhance vaginal moisture, try the herb cimicifuga racemosa, the extract of black cohosh that, in capsule form, builds up vaginal mucosa (Therapeuticum 1, 1987: 23-31). Traditional Chinese herbal formulas containing roots of rehmannia and dong quai have long been reputed to promote vaginal moisture.

    Clinical research in Germany also confirms the usefulness of black cohosh in preventing hot flashes and sweating, as well as relieving nervousness, achiness and depressed moods caused by suppressed hormone levels. It works on the hypothalamus (the body's thermostat, appetite and blood pressure monitor), pituitary gland and estrogen receptors. Green tea is steeped with polyphenols, mainly flavonoids, that exert a massive antioxidant influence against allergens, viruses and carcinogens. The risks of estrogen-related cancers such as breast cancer are particularly lowered by these flavonoids, as these substances head directly to the breast's estrogen receptors. About three cups a day exert an impressive anti-inflammatory, antiallergenic, antiviral and anticarcinogenic effect.

    Other phytoestrogen-rich botanicals, according to Susun Weed's Menopausal Years: The Wise Woman Way (Ash Tree Publishing), include motherwort and lactobacillus acidophilus to combat vaginal dryness; hops and nettles for sleep disturbances; witch hazel and shepherd's purse for heavy bleeding; motherwort and chasteberry for mood swings; dandelion and red clover for hot flashes.

    Our Need For Supplements

    Adding micronutrients at midlife to correct and counter a lifetime of poor diet and other habits is a step toward preventing the further development of the degenerative diseases to which we become vulnerable. At the very minimum, you should take:

    a multivitamin/mineral supplement vitamin E calcium

    Your multivitamin/mineral should contain vitamins A, B complex, C, D, E, calcium, magnesium, potassium, copper and zinc. Look for a wide variety of antioxidants that safeguard you from free radical damage, believed to promote heart disease and cancer, as well as contribute to the aging process.

    Also on the list: mixed carotenoids such as lycopene, alpha carotene and vitamin C; and folic acid to help regulate cell division and support the health of gums, red blood cells, the gastrointestinal tract and the immune system.

    Studies indicate a deficiency of folic acid (folate) in 30% of coronary heart disease, blood vessel disease and strokes; lack of folate is thought to be a serious risk factor for heart disease (OB.GYN News, July 15, 1997, page 28).

    Extra vitamin E is believed to protect against breast cancer and bolster immune strength in people 65 and older (Journal of the American Medical Association 277, 1997: 1380-86). It helps relieve vaginal dryness, breast cysts and thyroid problems and, more recently, hit the headlines as an aid in reducing the effects of Alzheimer's and heart disease. It is suspected to reduce the thickening of the carotid arterial walls and may prevent the oxidation of LDL (bad) cholesterol, which contributes to the formation of plaque in arteries.

    Selenium also has been identified as an assistant in halting cancer (JAMA 276, 1996: 1957-63).

    The Omegas To The Rescue

    Essential fatty acids found in cold water fish, flaxseed, primrose and borage oils and many nuts and seeds are essential for the body's production of prostaglandin, biochemicals which regulate hormone synthesis, and numerous physiological responses including muscle contraction, vascular dilation and the shedding of the uterine lining. They influence hormonal balance, reduce dryness and relieve hot flashes.

    In addition, the lignans in whole flaxseed behave like estrogen and act aggressively against breast cancer, according to rat and human studies at the University of Toronto (Nutr Cancer 26, 1996: 159-65).

    Research has demonstrated that these omega-3 and omega-6 fatty acids can reverse the cancer-causing effects of radiation and other carcinogens (Journal of the National Cancer Institute 74, 1985: 1145-50). Deficiencies may cause swelling, increased blood clotting, breast pain, hot flashes, uterine and menstrual cramps and constipation. Fatigue, lack of endurance dry skin and hair and frequent colds may signal EFA shortage. Plus, fatty fish oils, along with vitamin D and lactose, help absorption of calcium, so vital for maintaining bone mass.

    In addition, studies show that the natural substance Coenzyme A may help menopausal women reduce cholesterol and increase fat utilization (Med Hyp 1995; 44, 403, 405). Some researchers belive Coenzyme A plays a major role in helping women deal with stress while strengthening immunity.

    Still Suffering?

    Can't shake those menopausal woes? Menopause imposters may be imposing on you: The risk of thyroid disease, unrelenting stress, PMS, adrenal burnout, poor gastrointestinal health and hypoglycemia all increase at midlife. Menopause is a handy hook on which to hang every misery, ache and pain but it may only mimic the distress of other ailments. For this reason every midlife woman should have a good medical exam with appropriate tests to determine her baseline state of health. Only with proper analysis can you and your health practitioner hit on an accurate diagnosis and satisfying course of therapy.

    And if menopause is truly the issue, you have plenty of company. No woman escapes it. No woman dies from it. It is not a disease but a reminder that one-third of life remains to be lived. Menopausal Baby Boomers can anticipate tapping into creative energy apart from procreation. If not new careers, new interests await. An altered internal balance empowers a menopausal woman to direct, perhaps for the first time, her experience of life. She has come of age-yet again. Gone is the confusion, uncertainty, or dictates of a hormone driven life: This time wisdom and experience direct her. There is no need to yearn for youth or cower at the conventional covenant of old age. Menopause is the clarion call to reframe, reevaluate and reclaim.

    Mary Ann Mayo and Joseph L. Mayo, MD, are authors of The Menopause Manager (Revell) and executive editors of Health Opportunities for Women (HOW). Telephone number 877-547-5499 for more information.



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    Breast Cancer
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    Date: June 10, 2005 09:44 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Breast Cancer

    Breast Cancer by Joseph L. Mayo,MD Mary Ann Mayo, MA Energy Times, May 2, 1999

    What do you fear most? Bankruptcy? Floods? Heart disease? If you're like many women, breast cancer stands near the top of that dreaded list.

    But that fear doesn't permeate other cultures the way it does ours.

    A woman like Mariko Mori, for instance, 52 years old, Japanese, worries about intense pressures beginning to burden her toddler grandson. But worry about breast cancer? Hardly.

    In Indiana, Mary Lou Marks, 50, has similar family frets, mulling over her 28-year-old daughter's career choice.

    But on top of that, when Mary Lou tabulates her other worries, she recoils at the thought of breast cancer. She's heard about her lifetime risk: 1 in 8. Meanwhile, Mariko's is merely 1 in 40, according to Bob Arnot's Breast Cancer Prevention Diet (Little, Brown).

    American Problem
    Experts reporting in "Women at High Risk for Breast Cancer: A Primary Care Perspective" (Prim Care Update Ob/Gyns, vol. 5, no. 6, 1998, p. 269) say the risk of developing breast cancer for the average American woman during ages 40 to 59 is 3.9%; by 60 to 79 years of age that rises to 6.9%. A high-risk 40-year-old has a 20% chance of breast cancer in the next 20 years.

    New studies have found the effect of carrying the gene linked to breast cancer, which is responsible for only 5 to 10% of breast cancer incidence, is not as great as first suspected. Earlier estimates that the gene reflects an 80% chance of incurring breast cancer by age 70 has been recalculated to be only 37% (The Lancet, 1998;352:1337-1339).

    Complex Causesbr> Researchers agree: No one factor is solely responsible for breast cancer. Risk depends on many factors, including diet, weight, smoking, alcohol consumption, activity level and, of course, those genes.

    Regardless of their actual chance of getting breast cancer, women worry. Mary Lou faces no factors that would place her in particular jeopardy. But her anxieties about radical therapies and medical expenses paralyze her: She forgets to visit her health care provider and skips her annual mammogram appointments. Mary Lou's daughter, perhaps in reaction to her mother's gripping fears, campaigns ardently for cancer prevention, educating herself and mobilizing against the cumulative effects of known cancer risks. Smart young woman: A malignancy, after all, can take years to develop. A tumor must swell to one billion cells before it is detectable by a mammogram.

    Dietary Benefits
    Of all the tactics for reducing the risk of breast cancer, diet ranks high on the list.

    The soy-rich regimen of Japanese women like Mariko Mori, for example, helps to explain the low breast cancer rates in Asian countries (see box at center of the page).

    Tomatoes, because of their high quotient of the carotenoid lycopene, have been found to protect cells from the corrosive clutches of oxidants that have been linked with cancer in 57 out of 72 studies (The Santa Rosa Press Democrat, February 17, 1999, page A6, reporting on a Harvard Medical School study). For more on tomatoes see page 16.

    But there's no one magic anti-cancer food or diet. Eating to prevent breast cancer requires a balanced menu with fiber, healthy fats, phytoestrogens and antioxidants, all fresh and free of chemical additives.

    Modifying the balance and type of estrogen, the female sex hormone produced by the ovaries, offers an important breast cancer safeguard. Fat cells, adrenal glands and, before menopause, the ovaries, produce three "flavors" of estrogen, the strongest of which, estradiol, is believed to be carcinogenic when too plentiful or persistent in the body.

    Estrogen does its work by attaching to estrogen receptors. Receptors are particularly numerous in the epithelial cells that line milk sacs and ducts in the breasts.

    A receptor site is like a designated parking spot: Once estrogen is parked there it triggers one of its 400 functions in the body, from preparation of the uterus for pregnancy to intensifying nerve synapses in the brain.

    The food we eat can be a source of estrogen; plant estrogens, called phytoestrogens, are much weaker than the body's estrogens, but they fit the same receptors. Phytoestrogens exert a milder estrogenic effect than bodily estrogen and are capable of blocking the more potent, damaging versions.

    Finding Phytoestrogens
    Foods high in phytoestrogens include vegetables, soy, flaxseed and herbs such as black cohosh, chasteberry, red clover and turmeric. Soy is the darling of the day for good reason. Both soy and flaxseed can lengthen periods, reducing the body's overall exposure to estrogen.

    Soy also contains genistein, an "isoflavone" very similar in molecular form to estrogen but only 1/100,000 as potent. Because of its structure, genistein can attach to cells just as estrogen does; it also helps build carriers needed for binding estrogen and removing it from the body (Journal of Nutrition 125, no.3 [1995]:757S-770S). It acts as an antioxidant to counteract free radicals.

    Tumor Inhibition
    Studies have demonstrated that genistein inhibits angiogenesis (new tumor growth), slowing the progression of existing cancer.

    Soy is most protective for younger women. Postmenopausal women benefit from soy's ability to diminish hot flashes and for cardiovascular protection, especially in combination with vitamin E, fiber and carotene (Contemporary OB/GYN, September 1998, p57-58).

    Experts don't know that much about the cumulative effect of combining hormone replacement with soy, herbs and a diet high in phytoestrogens. Menopausal women who boost their estrogen this way should work with their health care providers and monitor their hormonal levels every six to 12 months with salivary testing.

    The Vegetable Cart
    Some vegetables are particularly protective against breast cancer because they change the way the body processes estrogen. Indol-3-carbinol, found in the co-called cruciferous vegetables such as cauliflower, broccoli and cabbage, diminishes the potency of estrogen. (Broccoli also contains isothiocyanates that trigger anti-carcinogenic enzymes.) These vegetables supply fiber, beta-carotene, vitamin C as well as other vitamins and minerals (Proc of the National Academy of Science USA, 89:2399-2403, 1992).

    Fiber from fruits, vegetables and whole grains reduces insulin levels and suppresses the appetite by making make us feel full, thus helping with weight control, so important to resisting cancer. Fiber also helps build estrogen carriers that keep unbound estrogen from being recirculated and reattached to the breast receptors.

    Cellulose, the fruit and vegetable fiber most binding with estrogen, also rounds up free radicals that damage DNA within cells.,p> Feeding the Immune System Despite heightened public awareness and efforts to stick to wholesome, healthful diets, experts increasingly link poor nutrition to depressed immune systems. Many Americans are at least marginally deficient in trace elements and vitamins despite their best attempts to eat well; that's why a good multivitamin/mineral is wise, even mandatory. Vitamins given to people undergoing cancer treatment stimulate greater response, fewer side effects, and increased survival (International Journal of Integrative Medicine, vol. 1, no. 1, January/February 1999).

    Nutrients tend to work synergistically on the immune system. They should be taken in balanced proportions, and in consultation with your health care provider.

    Immune Boosters
    In Research links low levels of calcium and vitamin D, an inhibitor of cell division and growth, to higher breast cancer rates.

    n Riboflavin (B2), pyridoxine (B6), pantothenic acid (B5), zinc and folate strengthen immunity. Selenium, in lab culture and animal studies, has helped kill tumors and protect normal tissues.

    n Beta-carotene and vitamins A, E and C are antioxidants. Vitamin C enhances vitamin E's effects, boosting immunity and protecting against cell damage. The antioxidant isoflavones in green tea, with soy, convey the anticancer effects of the Asian diet. Research shows actions that discourage tumors and gene mutations.

    The food you eat influences hormones. Excess sugar raises insulin, which acts as a growth factor for cancer and interferes with vitamin C's stimulation of white blood cells. It may contribute to obesity.

    Alcohol is converted to acetaldehyde, which causes cancer in laboratory animals. It affects gene regulation by decreasing the body's ability to use folic acid. It increases estrogen and the amount of free estradiol in the blood. The liver damage that accompanies high alcohol consumption frequently reduces its capacity to filter carcinogenic products, regulate hormones and break down estrogen. Studies of alcohol consumption have caused experts to estimate that drinking more than two alcoholic beverages a day increases breast cancer risk by 63% (OB-GYN News, November 1, 1998, p. 12).

    Fat Can be Phat
    Fat conveys nutritional benefits. Not all fats are bad: we can't survive for very long without certain fats. Fat can turn you into a "well-oiled" machine. But the wrong kind of fat (the fatty acids in red meats and fatty poultry) is believed to be a major culprit in breast cancer.

    Fat cells produce estrogen. Excess fat stores carcinogens and limits carriers that can move estrogen out of your system.

    Once estrogen has attached itself to a receptor, the health result depends on the type of fat in the breast. Saturated fat, transfatty acids and omega-6 fat from polyunsaturated vegetable oils such as safflower oil, peanut, soybean oil, corn oil and in margarine can increase the estrogen effect and trigger a powerful signal to the breast cell to replicate.

    Restraining Prostaglandins
    Blood rich in the essential fatty acids omega-3 and omega-9 lowers cancer risk by driving down levels of prostaglandins, which promote tumor growth. The blood and tumors of women with breast cancer usually contain high levels of prostaglandins.

    Breast tissue is protected by omega-3 fat chiefly from fish and flaxseed and by omega-9 from olive oil. Salmon once a week or water packed tuna three times a week are particularly beneficial. Fish oil supplements processed to reduce contaminates are available. Cod liver oil isn't recommended: its vitamin A and D levels are too high.

    Flaxseed is the richest known plant source of omega-3. Use a coffee grinder to benefit from the seed and oil for the full estrogen effect; sprinkle ground flaxseed over cereal or fold into baked goods. Drizzle flaxseed oil, found in the refrigerator section of your health food store, over salads or cereal. (Store the oil in the refrigerator.)

    Olive oil, especially in the context of the so-called Mediterranean diet of vegetables, omega-3-rich fish and fresh fruit (Menopause Management, January-February 1999, p. 16-19), lowers the risk of breast cancer (The Lancet, May 18, 1996;347:1351-1356).

    Selecting Organic Food
    Select organic foods for extra anticancer protection. Pesticides stimulate erratic cell action and often inhibit the estrogen carrier's ability to attach and remove estrogen from the body. Free floating estrogen then can attach to breast receptors and cause trouble.

    Buy or grow fresh, organic foods whenever you can. When grilling meat, fish or poultry, reduce the area where carcinogens may accumulate by trimming fat. Charred, well-done meat is known to be carcinogenic. When grilling, marinate meat first and reduce the cooking time on the grill by slightly precooking.

    Cancer prevention is an interlocking puzzle requiring the limitation of fat consumption, weight control, exercise, stress reduction and care for psychological and spiritual balance. Possessing more cancer fighting pieces makes you more likely to be able to complete the prevention picture.

    Joseph L. Mayo, MD, FACOG and Mary Ann Mayo, MA, are the authors of The Menopause manager: A Safe Path for a Natural Change, an individualized program for managing menopause. The book's advice, in easy-to-understand portions, isolates in-depth explanations with unbiased reviews of conventional and alternative choices. A unique perspective for mid-life women who want to know all their options.

    Also from the Mayos - The HOW Health Opportunities For Women quarterly newsletter to help women learn HOW to make informed health choices. Learn HOW to: - Choose nutritional supplements

  • - Integrate natural remedies with conventional medicine.
  • - Pick healthier foods.
  • - Reduce breast cancer, osteoporosis and heart disease risk.
  • - Slow aging's effects. Protect against environmental toxins.



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    PYCNOGENOL ® - The Ultimate Antioxidant
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    Date: June 04, 2005 02:04 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: PYCNOGENOL ® - The Ultimate Antioxidant

    Pycnogenol

    Pycnogenol® is a breakthrough in antioxidant protection that demonstrates how important natural nutrition can be for your health. Antioxidants are a class of biological molecules that function to scavenge and neutralize free radicals. Free radicals are molecules with unpaired electrons that cause damage at the cellular level, and which unfortunately are unavoidable. Antioxidants – the most famous of which thus far have been Vitamin C and Vitamin E – work to protect living tissue by neutralizing free radicals, thereby interrupting many of their harmful activities. Pycnogenol®, one of the most powerful antioxidants yet discovered, is the proprietary name of a natural plant product made from the bark of the European coastal pine, Pinus maritima. It is 20 times more potent an antioxidant than Vitamin C, and 50 times more so than Vitamin E.

    Free radicals are a real threat

    Uniquely vulnerable targets of free radical attack that require a regular supply of antioxidants just to maintain a basic level of function include fatty acids – especially those in cell membranes – and sulfhydral proteins, which form one of the most common types of chemical bonds found in biological organisms. The importance of these substances for overall health cannot be overstated, as they are critical components not only of tissues throughout the body, but most importantly, of the principal regulatory organs – the brain and liver – and every blood vessel. Free radical attack on fatty acids – known as lipid peroxidation – and related destruction of sulfhydral proteins can lead to diminished function of cell membranes and whole organs. This, in turn, can contribute significantly to decreases in quality of life.

    Free radicals are believed to be active in the development of cumulative damage to the system, as well as in many of the undesirable effects of aging. Free radicals are constantly being produced due to the natural intake of oxygen and generation of energy by the body’s cells. However, their production is heightened by pollutants such as tobacco smoke, alcohol, solvents, and oxidized cholesterol from foods. Therefore, health scientists suggest we may need to increase our intake of antioxidants either from foods or from supplements – such as Vitamin A and Beta Carotene, Vitamins C and E, Selenium, Cysteine, and now, Pycnogenol®.

    Potent antioxidant protection from nature - Pycnogenol®

    Originally discovered by renowned scientist Jacques Masquelier, Pycnogenol® is a natural 85% to 95% concentrate of proanthocyanidins extracted from the bark of the Maritime Pine. Proanthocyanidins are a special class of highly bioavailable, water-soluble bioflavonoids with unparalleled free radical scavenging activity. They readily cross the Blood-Brain Barrier to provide antioxidant protection to the central nervous system, and stay in the bloodstream for approximately 72 hours. Thirty years of sound European research shows that proanthocyanidins from Pycnogenol® are highly beneficial with no evidence of adverse effects, even after more than ten years of use. They also show no loss in potency after 12 years of storage.

    Better health for an active life

    As a potent antioxidant, Pycnogenol® is valuable for protecting the liver from free radical attack. Since the liver is the main detoxifying, nutrient-assimilating, and energy-generating organ of the body, this may mean more potential for activity in your life. Pycnogenol® may also aid recovery for athletes on strenuous workout regimes and in competition.

    Healthy capillaries through healthy collagen

    A major beneficiary of the protective actions of Pycnogenol® is collagen, the most abundant protein in the body. Collagen is responsible for maintaining the integrity of “ground substance,” the basic material in functional fluids, mucus linings, and connective tissue such as tendons, ligaments, cartilage, and most importantly, blood vessels linings. It is highly vulnerable to free radical attack, and a number of discomforting and depreciating processes are associated with its destruction. There is evidence showing that Pycnogenol® can provide remarkable support for the prevention of collagen destruction, and it has received much attention for its special affinity for capillaries, the smallest blood vessels. Pycnogenol® helps strengthen capillary linings in three key ways. First, Pycnogenol® functions to scavenge the free radicals that may compromise the integrity of collagen. Second, Pycnogenol® contains catechin, which is thought to stabilize collagen by forming hydrogen bonds and cross-linking collagen. Third, Pycnogenol® is Vitamin C-sparing, meaning it can fill in for C in a number of functions; this frees some Vitamin C – required for the synthesis of hydroxproline, a major structural amino acid of collagen – for use in building collagen. People who smoke and women who take oral contraceptives can reduce their heightened risk of Vitamin C depletion by taking advantage of Pycnogenol®’s Vitamin C-sparing activity.

    Look to Source Naturals® for 25 mg, 50 mg, 75 mg, & 100 mg tablets of this natural wonder!

    References

  • • Hagerman, A. and L. Butler. “The specificity of proanthocyanidin-protein interactions.” Journal of Biological Chemistry 256 (1981): 4494-97.
  • • Kuttan, R., et al. “Collagen treated with catechin becomes resistant to the action of mammalian collagenase.” Experienta. 37 (1981): 221-23.
  • • Masquelier, J. Natural Products as Medicinal Agents “Pycnogenol®s: Recent Advances in the Therapeutical Activity of Proanthocyanidins” (pp. 243-65). Stutgart, Germany: Hippokrates Verlag, 1981.
  • • Maunier, M.T., E. Duroux, and P. Bastide. “Free-radical scavenger activity of procyanidolic oligomers and anthocyanosides with respect to superoxide anion and lipid peroxidation.” Plantes Medicinales et Phytotherapie, 23.4 (1989): 267-74.



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    PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ...
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    Date: June 04, 2005 11:08 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ...

    All we have ever known or will ever feel, begins and ends with the hundreds of billions of nerve cells that form our brain. Without them, there can be no experience; for us, nothing would exist. Our mind and personality, the sense of who we are, emanate from this immensely intricate system of nerves. The brain’s remarkable ability to perceive and perform, remember and learn, is severely challenged by today’s social and physical environment. These environmental factors accelerate the decline in nerve cell activity that normally occurs with age. Recent clinical research is revealing how previously unrecognized nutrients can strengthen the body’s natural defenses against age-related cognitive decline. Source Naturals is proud to present the latest breakthrough in nutritional support for the brain: PHOSPHATIDYL SERINE.

    Phosphatidyl Serine (PS) is a phospholipid which forms an essential part of every human cell, but it’s particularly concentrated in the membranes of nerve cells. Since the electronic messages that communicate and regulate every aspect of our lives travel along nerve cell membranes, the structural integrity of these membranes is imperative to our health. The nerve cell membrane is the site where molecules of sodium and potassium exchange electrons, causing the electrical impulse to be generated. This bio-electric current then travels along the membrane to trigger the release of neurotransmitters. These are the chemical messengers that cross synapses (gaps between nerve cells) to relay information to neighboring nerve cells. This sets other electrical currents in motion– along thousands of other nerve cells. This happens billions of times each second, and is how the brain and nerves coordinate and communicate with the rest of the body. PS has a very important function in the nerve cell membrane. As a key bio-structural molecule, PS provides vital support for the membrane proteins that enable nerve cells to communicate and grow.

    Regulating the Flow

    Unlike other cells in the body, nerve cells do not reproduce. Instead, they repair and rebuild themselves, using proteins called Nerve Growth Factor (NGF). Experiments verify that PS enhances the synthesis and reception of NGF, which tend to drop off radically with age.1 PS supplements enhance the cerebral cortex’s output of acetylcholine, the neurotransmitter associated with our ability to think, reason, and concentrate. PS also stimulates the synthesis and release of dopamine, related to heightened states of attention.2 The brain’s response to stress also appears to be related to PS. When healthy young men were subjected to exercise-induced stress, those taking PS had a lowered stress response. This was measured by blood levels of ACTH, the pituitary hormone that triggers the adrenals to secrete the stress hormone cortisol.3

    Well-Tested

    Subjects taking PS showed increased levels of brain energy metabolism and scored higher on cognitive tests.4 Behavioral factors were also measured in elderly subjects; PS positively affected their mood states.5 Over 23 clinical trials have investigated the effect of PS supplements on more than 1200 human subjects, ages 40-93. Consistent and statistically significant results suggest that PS supports brain functions that tend to diminish with age.

    Wellness Redefined

    Nutritional research continually reveals new potentials for wellness. Source Naturals is committed to helping people achieve a fulfilling life, and a fully functioning nervous system is central to this aim. Source Naturals PHOSPHATIDYL SERINE can help support your body’s natural regenerative processes, keeping your brain healthy and vital for a long, long time. Experience the difference with Source Naturals PHOSPHATIDYL SERINE.

    References:
    1. Aporti, F., et al., 1986. “Age-dependent spontaneous EEG bursts in rats: effects of brain phosphatidylserine.” Neurobiology of Aging 7: 115-120. 2. Caffarra, P., and V. Santamaria, 1987. “The effects of phosphatidylserine in subjects with mild cognitive decline.” Clin. Trials J. 24: 109-114. 3. Heiss, W.D., et al., 1993. “Activation PET as an instrument to determine therapeutic efficacy in Alzheimer’s Disease.” Annals N.Y. Acad. Sci. 695: 327-31. 4. Monteleone, P., et al., 1990. “Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.” Neuroendocrinol. 52: 243-48. 5. Nunzi, M.G., et al., 1990. “Therapeutic properties of phosphatidylserine in the aging brain.” In, Phospholipids: Biochemical, Pharmaceutical and Analytical Considerations (ed. I. Hanin and G. Pepeu). New York: Plenum Press.



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    TopPreviousNext

    Date: May 31, 2005 04:39 PM
    Author: Darrell Miller (dm@vitanetonline.com)

    Acetyl-L-carnitine is truly a mind-body nutrient. It helps synthesize acetylcholine, the brain's principal neurotransmitter responsible for learning and memory. And it is a more bioavailable form of L-carnitine, an amino acid derivative that performs the vital function of transporting longchain fatty acids into the cellular mitochondria where they are oxidized to generate metabolic energy. Supplemental acetyl-L-carnitine supports the activity of brain cells that depend on acetylcholine. It can also reduce the metabolic waste products that damage cells over time. As one of the most important nutrients to help slow the aging process, acetyl-L-carnitine is at the heart of Source Naturals' commitment to empower people to take charge of their own health.

    Acetylcholine is the brain's principal neurochemical of thought. Neurons need it to communicate with each other, especially to create and recall memories. Acetylcholine is also involved in muscular coordination. At neuromuscular junctions throughout the body, it tells muscles when to contract. But the efficiency of cells that use acetylcholine naturally declines with age, partly because of decreased activity of the enzyme that synthesizes this neurotransmitter.

    Neurotransmitter Production

    Acetylcholine is created when the enzyme choline acetyl transferase (CAT) attaches an acetyl group to a choline molecule. CAT activity is heightened by acetyl-L-carnitine, which donates its acetyl group. Acetyl-L-carnitine is made in small amounts naturally in the body, but its production begins to decline in midlife. In well-controlled human studies, supplemental acetyl-L-carnitine slowed the progress of mental decline by notably improving attention and memory. When supplemental acetyl-L-carnitine was combined with lipoic acid (a powerful natural antioxidant), significant improvement in memory was seen in animals. Researchers said that together the two chemicals "tune up" the mitochondria, the energy-producing organelles that power all cells. Mitochondrial decay is believed to be the primary reason for age-related deterioration of cognitive function and energy levels.

    Cellular Energy and Protection

    As the active form of L-carnitine, acetyl L-carnitine efficiently transports long-chain fatty acids into the mitochondria where they are converted into ATP (adenosine triphosphate), the energy molecule. Animal studies suggest that supplemental acetyl L-carnitine has a positive effect on energy generation as well as on the structural integrity of aging mitochondria. By supporting fatty acid metabolism, acetyl L-carnitine also helps reduce lipofuscin, a metabolic waste product composed of damaged proteins and rancid fats. The brown "liver spots" on some elderly hands are composed of this aging pigment that gradually builds up in cells of the heart, liver, brain, and lens of the eye.

    Muscle Performance

    Ninety-five percent of the body's carnitine is found in muscle cells, especially in the heart where mitochondria comprise nearly 50% of a cell's volume. During prolonged exercise, muscles have a high demand for carnitine because fats can account for up to twothirds of the energy burned. L-carnitine supplements can increase exercise endurance and reduce fatigue. Acetyl L-carnitine is also a key nutrient in Source Naturals' legendary neuroceutical formulas MEGAMIND™ and HIGHER MIND™. And because acetyl L-carnitine also generates the basic energy that affects all biological and mental processes, this mind-body nutrient is one of the few nutritional compounds with such a broad range of action in maintaining youthful functioning. Source Naturals ACETYL L-CARNITINE is therefore an essential part of a smart strategy to live well, age well.

    References

    Carta A. and M. Calvani. Acetyl-L-carnitine: a drug able to slow the progress of Alzheimer's disease? Ann NY Acad Sci 1991; 640: 228-232. Hagen T.M. et al. August 4, 1998. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci USA 95(16):9562-6. Liu J. et al. February 19, 2002. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. PNAS 99(4):1876-81. Spagnoli A.U. et al. 1991. Long-term acetyl-L-carnitine treatment in Alzheimer’s disease. Neurology. 41(11):1726-1732.



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