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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms Hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and Hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, Hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a Hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal Hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, Hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Is Your Cinnamon Causing Inflammation? The Hidden Risks of a Common Spice
Date:
July 16, 2026 05:28 PM
Cinnamon is widely praised for its ability to improve cellular glucose uptake and support insulin sensitivity, but the direct answer is yes - under specific conditions, consuming cinnamon can cause or trigger inflammation. While cinnamon naturally contains powerful anti-inflammatory polyphenols (like cinnamaldehyde), its potential to drive inflammation boils down to two distinct triggers: the specific variety you ingest, and your individual immune response to its volatile oils. 1. Coumarin-Induced Liver InflammationThe primary metabolic risk stems from Cassia cinnamon, which is the standard, inexpensive variety found on most grocery store spice racks. Cassia contains significant concentrations of a naturally occurring compound called coumarin.
2. Contact Hypersensitivity (Cinnamon Stomatitis)Cinnamaldehyde gives cinnamon its signature warmth and flavor, but it is also a documented contact allergen.
3. Gastrointestinal Mucosal IrritationBecause concentrated spice powders contain highly concentrated volatile oils, taking large doses on an empty stomach can physically irritate the delicate mucous lining of the upper gastrointestinal tract. This localized chemical irritation can mimic or exacerbate inflammatory discomfort in the stomach wall, resulting in heartburn, acid reflux, or cramping.Mitigating the Risk: Ceylon vs. CassiaIf you are leveraging cinnamon as a daily tool for metabolic health and blood sugar management, switching to Ceylon cinnamon (often labeled as "True Cinnamon") fundamentally changes its biochemical impact.
While cinnamon is highly regarded for improving insulin sensitivity and managing blood sugar, it can paradoxically trigger inflammation under specific conditions. The primary systemic risk stems from Cassia cinnamon, the common grocery store variety, which contains high concentrations of a compound called coumarin. When consumed regularly or in large therapeutic doses, coumarin can overwhelm the liver's metabolic pathways, leading to elevated liver enzymes and acute hepatic inflammation. Beyond liver toxicity, cinnamon can also incite localized inflammation; its volatile oil, cinnamaldehyde, can induce a Type IV delayed Hypersensitivity reaction known as contact stomatitis - causing painful burning and swelling in the mouth - while concentrated doses can physically irritate the gastrointestinal lining. To safely harness the metabolic benefits of the spice without triggering these inflammatory responses, switching to Ceylon cinnamon ("true cinnamon") is the most effective strategy. Systemically, Ceylon contains only trace, negligible levels of coumarin (0.004% to 0.007%), making it safe for daily medicinal dosing, whereas Cassia contains significant levels (up to 1.0%) that require strict consumption limits to avoid toxicity. Visually and structurally, the two varieties are distinctly different: Ceylon features a light tan color with multiple thin, fragile, and tightly rolled layers, while Cassia is characterized by a dark reddish-brown hue and a single, thick, hard quill that is difficult to break.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6645) Does Methylation Effect Active Vitamin D3 Levels in the body?
Date:
July 08, 2026 12:43 PM
Yes, methylation directly and significantly impacts how efficiently your body converts Vitamin D3 into its active, usable form. This relationship operates on two distinct levels: epigenetic DNA methylation (which acts as a volume knob for the conversion enzymes) and the cellular methylation cycle (which shares a profound reciprocal feedback loop with active Vitamin D). To see exactly where methylation interferes, it helps to look at the standard two-step activation pathway:
1. DNA Methylation (The Epigenetic "Dimmer Switch")DNA methylation is an epigenetic mechanism where methyl groups are attached to a gene's promoter region, typically silencing or "turning down" its expression.
2. The Systemic Methylation Cycle Feedback LoopWhile S-adenosylmethionine (SAMe) is not a direct chemical cofactor required for the hydroxylation reactions themselves (which rely on NADPH and the cytochrome P450 enzyme network), the systemic methylation cycle and Vitamin D share a massive reciprocal cross-talk mechanism.
The Vitamin D "Non-Responder": Is Your DNA Dimming Your Supplement’s Power? Yes, higher active Vitamin D3 levels consistently cause homocysteine levels to drop. Large-scale observational studies and gold-standard randomized controlled trials (RCTs) confirm a distinct, inverse relationship: as your Vitamin D status optimizes, circulating total homocysteine decreases. When active D3 binds to the Vitamin D Receptor (VDR), it triggers specific genetic and cellular actions that clear homocysteine through multiple pathways. The Biological MechanismsActive Vitamin D doesn’t just lower homocysteine through one pathway; it exerts a multi-pronged push to keep the toxic amino acid from accumulating.1. Upregulation of Methionine Synthase (MTR)While active D3 supports the alternative BHMT (betaine) pathway, recent molecular research highlights an even more direct impact on the primary, folate-dependent remethylation loop.
2. Safeguarding Enzyme Function via Oxidative Stress ReductionThe primary enzyme responsible for clearing homocysteine, Methionine Synthase, is incredibly sensitive to oxidative stress. Under high inflammation or oxidative conditions, the cobalt atom at the heart of its B12 cofactor becomes oxidized, completely disabling the enzyme and causing a major homocysteine backup.
3. Preserving Liver and Kidney FunctionThe alternative remethylation pathway, BHMT, operates almost exclusively in the liver and kidneys. If these organs experience structural or metabolic strain, their capacity to process homocysteine drops drastically. Active Vitamin D protects hepatic and renal tissue architecture, ensuring the local cellular machinery required for the betaine-homocysteine conversion remains functional.What the Clinical Trials ShowIn human trials, the drop isn't just theoretical - it's highly measurable.The Clinical Evidence: In double-blind, randomized, placebo-controlled trials, individuals with low baseline Vitamin D and elevated homocysteine were given high-dose Vitamin D3 (e.g., 50,000 IU weekly) over a two-month period. The treatment groups consistently showed statistically significant drops in total serum homocysteine, alongside reductions in body mass index (BMI) and systemic inflammatory markers, while the placebo groups saw no change. If someone is dealing with stubborn Hyperhomocysteinemia (elevated homocysteine) and pushing hard on methylated B-vitamins (like methylfolate and TMG/betaine) without seeing their numbers budge, a hidden Vitamin D deficiency or a high-methylation genetic barrier at the CYP2R1 liver enzyme is very frequently the missing link. Summary: The relationship between Vitamin D3 activation and the body's biochemical pathways operates as a highly coordinated, reciprocal feedback loop. On an epigenetic level, DNA methylation acts like a cellular dimmer switch for the liver enzyme CYP2R1, which is responsible for converting raw D3 into its circulating form. When the promoter region of this gene is heavily methylated, enzyme production is suppressed, explaining why some individuals act as clinical "non-responders" who struggle to raise their blood levels even with high-dose supplementation. Once Vitamin D is successfully activated, however, it turns around and directly reinforces the systemic methylation cycle by binding to the Vitamin D Receptor (VDR) and upregulating the BHMT gene, which is vital for maintaining the body's universal methyl donor (SAMe) pool. Conversely, maintaining robust levels of active Vitamin D3 plays a direct, clinically proven role in forcing circulating homocysteine levels to drop. When active D3 binds to its receptor, it triggers a multi-pronged clearance strategy by activating the Nrf2 cellular defense pathway, which upregulates Methionine Synthase (MTR) - the primary enzyme that converts toxic homocysteine back into harmless methionine. Furthermore, by acting as a powerful systemic anti-inflammatory, active Vitamin D lowers the oxidative stress that would otherwise oxidize and disable the delicate B12 cofactors inside these clearance enzymes. This dual action of increasing enzyme production while shielding existing enzymes from environmental damage explains why clinical trials consistently show significant reductions in serum homocysteine when Vitamin D status is optimized.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6644) Is there anything else DLPA can do be sides Pain management and Mood?
Date:
May 22, 2026 04:29 PM
Here is what else DLPA can do:
When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.
Here are a few of the more complex, nuanced roles of DLPA in the body:
By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.
Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.
The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.
Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?
Summary:
Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.
In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6640)
Date:
April 15, 2026 02:04 PM
When you are under stress, your cells can become flooded with calcium, which "excites" the cell. Magnesium sits at the "gate," ensuring that only the necessary amount of calcium enters. Without enough magnesium, cells become Hyper-excitable, leading to oxidative stress, inflammation, and even cell death. Furthermore, magnesium is a required co-factor for the production and stability of ATP (adenosine triphosphate), the primary energy currency of the cell. In fact, ATP is usually found in the body as a complex called Mg^2+-ATP.
However, many functional medicine experts argue this number is actually higher because the RDA is designed to prevent acute deficiency, not to optimize health. Furthermore, magnesium is stored in bones and soft tissue, not the blood, meaning standard "Serum Magnesium" blood tests often miss a deficiency until it is dangerously low.
Unlike Magnesium Oxide (which has poor absorption) or Magnesium Citrate (which can have a laxative effect), Magnesium Glycinate is chelated with the amino acid glycine. This makes it:
Here are the additional benefits you might notice once your magnesium "tank" is full:
Magnesium acts as the body's essential "biological coolant," stabilizing cellular integrity by regulating calcium influx and powering nearly every metabolic process as a co-factor for Mg^2+-ATP. Despite its critical role, more than half of the American population remains chronically deficient, a silent crisis fueled by mineral-depleted industrial soil and the stripping of nutrients during food processing. Transitioning to a high-quality supplement like Magnesium Glycinate offers a superior path to replenishment because its chelated form is both highly bioavailable and gentle on the digestive system. Once levels are restored, the systemic "re-tuning" manifests as a profound shift in well-being, ranging from enhanced sleep quality and stress resilience to improved bone density, hormonal balance, and DNA repair, effectively moving the body from a state of Hyper-excitable stress to one of optimized physiological stability.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6637)
Date:
November 20, 2025 12:16 PM
In the context of the colon, the paradox states that butyrate is a promoter of life for healthy colon cells but an inducer of death (apoptosis) for colon cancer cells.
Regarding its effects on all cancers throughout the body, studies show that butyrate's pro-apoptotic (death-inducing) properties are not limited to colon cancer, but the paradox itself is largely defined by the unique metabolic environment of the colon.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6629)
Date:
June 06, 2024 05:20 PM
Allergies and sinus issues can be a constant thorn in the side for many individuals. Everyday activities can feel like an uphill battle when you're plagued by congestion, sneezing, and itchy eyes. But what if there was a natural remedy that could provide relief across multiple body systems? Introducing Allercetin™ Allergy & Sinus, a Bio-Aligned Formula designed to tackle the root causes of your allergy symptoms.
Allercetin™ is not your average allergy treatment. This innovative product leverages natural homeopathic remedies to address the complex web of systems involved in allergic reactions. Unlike many over-the-counter medications that offer temporary relief, Allercetin™ provides a comprehensive approach, targeting the respiratory system, sinuses, mucous membranes, and more.
The key to Allercetin™'s effectiveness lies in its Bio-Aligned Formula. This advanced blend of natural ingredients is designed to support multiple body systems that are often affected by hay fever and other allergic conditions.
Breathing becomes a chore when your respiratory system is compromised by allergens. Allercetin™ contains ingredients that help to open up the airways, making it easier to breathe. This can be particularly beneficial during high pollen seasons when respiratory issues are at their peak.
Your sinuses play a crucial role in trapping allergens and preventing them from entering your respiratory system. However, when they become inflamed, they can cause severe discomfort. Allercetin™ supports the health of your sinuses, promoting natural drainage and reducing inflammation.
Mucous membranes are the body's first line of defense against airborne irritants. Allercetin™ helps to maintain the integrity of these membranes, ensuring they function optimally. This reduces the likelihood of allergens causing significant irritation and discomfort.
Histamines are chemicals in the body that play a central role in allergic reactions. When released in large amounts, they can cause symptoms like itching, swelling, and redness. Allercetin™ works to inhibit the release of histamines, thus reducing the severity of allergic reactions.
A Hyperactive immune system can exacerbate allergy symptoms. Allercetin™ includes ingredients that help to desensitize the immune system, making it less reactive to allergens. This not only alleviates current symptoms but can also reduce the likelihood of future allergic reactions.
When your body is fighting allergies, it can drain your energy levels significantly. Allercetin™ supports cellular energy production, ensuring you have the stamina to go about your daily activities with ease.
Using Allercetin™ is simple and convenient. Take the recommended dosage as indicated on the packaging, preferably at the onset of symptoms. Consistency is key to experiencing the full benefits of this natural remedy.
Multiple factors set Allercetin™ apart from other allergy treatments on the market. Here are some reasons why you should consider making it a staple in your wellness routine:
Don't just take our word for it; listen to what our satisfied customers have to say:
Rigorous scientific research guided the development of Allercetin™. We selected each ingredient based on its ability to alleviate symptoms and support overall well-being. This guarantees you receive a product supported by both traditional wisdom and modern science.
Living with allergies and sinus issues doesn't have to be an ordeal. With Allercetin™ Allergy & Sinus, you can take a proactive approach to manage your symptoms naturally and effectively. Why settle for temporary relief when you can address the root causes of your discomfort? Experience the transformative power of Allercetin™ for yourself. Don't let allergies hold you back any longer. Visit our website today to purchase Allercetin™ Allergy & Sinus and reclaim your life from the shackles of allergies. Take the first step towards a healthier, more comfortable life—order now!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6613)
Date:
May 29, 2024 05:02 PM
Stevia has gained significant popularity as a natural sweetener, but with popularity comes a wave of misconceptions and myths. As consumers become more health-conscious and seek alternatives to sugar, it’s essential to separate fact from fiction regarding Stevia. This article debunks stevia myths with evidence-based info to clarify consumer doubts.
One of the most prevalent myths about stevia is that it is artificial. In reality, stevia is a completely natural sweetener derived from the leaves of the Stevia rebaudiana plant. The plant has been used for centuries by indigenous people in South America for its sweetening properties. Unlike artificial sweeteners such as aspartame or saccharin, stevia is derived from a natural source and processed to extract its sweet components, known as steviol glycosides.
Another common misconception is that stevia is harmful to health. Scientific studies and regulatory organizations have repeatedly confirmed the safety of stevia. The Food and Drug Administration (FDA) classifies high-purity stevia extracts as "Generally Recognized as Safe" (GRAS) for consumption. Furthermore, research indicates that stevia can have health benefits like lowering blood pressure and blood sugar levels, making it a suitable sweetener for individuals with diabetes and Hypertension.
Some people believe that stevia has a bitter aftertaste, which makes it less appealing as a sweetener. While early formulations of stevia extracts indeed presented a noticeable bitter aftertaste, advancements in processing have minimized this issue. Modern high-purity stevia products are often combined with other natural sweeteners or flavor enhancers to improve taste, making them virtually indistinguishable from sugar in many applications.
While it’s true that stevia is an excellent sweetener for individuals managing diabetes due to its zero-calorie and zero-carbohydrate nature, it is not exclusive to them. Anyone looking to reduce sugar consumption or seeking a natural alternative can benefit from using stevia. It is a versatile sweetener that can be used in a variety of foods and beverages, making it suitable for the general population striving for a healthier lifestyle.
Not all stevia products are created equal. The purity and quality of stevia extracts can vary significantly between products. It's crucial to read labels and choose products that contain high-purity stevia extracts, as some products on the market contain added fillers or lower-grade stevia. By selecting reputable brands and scrutinizing ingredient lists, consumers can ensure they are using high-quality stevia that meets their health standards. Kal Sure Stevia Extract is one of those high-quality brands that stand out in the market. Known for its commitment to purity and potency, Kal Sure Stevia Extract offers a product that is free from fillers and unnecessary additives. The brand’s stringent quality control measures ensure that each batch contains only high-purity stevia extracts, delivering consistent sweetness without the aftertaste. Consumers can trust Kal Sure Stevia Extract as a safe, reliable, and pleasant-tasting alternative to conventional sugar. When choosing a stevia product, it's essential to opt for a brand like Kal Sure stevia to enjoy the full benefits of this natural sweetener.
Some believe that consuming stevia can trigger allergies. However, stevia is generally considered hypoallergenic and does not commonly cause allergic reactions. There have been few documented cases of stevia allergies, and these are typically related to individuals with specific sensitivities. For the vast majority of people, stevia is a safe and well-tolerated sweetener, even for those with common food allergies.
The notion that stevia contributes to weight gain is counterintuitive, given its zero-calorie nature. Unlike sugar, which is high in calories and contributes to weight gain, stevia provides sweetness without adding calories. Using stevia instead of sugar can help reduce overall caloric intake, aiding in weight management efforts. Multiple studies have shown that replacing sugar with stevia can be an effective strategy for achieving and maintaining a healthy weight.
Concerns about stevia disrupting metabolism are unfounded. Research indicates that stevia neither affects metabolic rates nor alters insulin sensitivity in a negative manner. On the contrary, stevia has been shown to have a neutral or even beneficial impact on metabolism, particularly for individuals with metabolic disorders like diabetes. It allows for sweetening without the metabolic consequences associated with high sugar consumption.
There is a misconception that stevia is unsuitable for baking due to its chemical composition. While it is true that baking with stevia requires some adjustments—since it does not have the same physical properties as sugar—it can still be used effectively. Bakers often use stevia in combination with other ingredients to achieve the desired texture and sweetness. Many recipes and commercial products have successfully incorporated stevia, proving its versatility in baking applications.
Consumers sometimes think that switching to stevia will significantly increase their grocery bills. While high-purity stevia products may be more expensive per ounce than sugar, they are much sweeter. A small amount of stevia goes a long way, which means that even a small container can last a long time. In the long run, the cost of stevia can be comparable to or even less than sugar, particularly when considering the health benefits and potential medical cost savings from reduced sugar consumption. Brands like Kal Stevia 3.5 oz contains 1800 servings per container.
It is crucial to approach any information about stevia with a critical eye and rely on evidence-based data rather than myths. Stevia is a natural, safe, and versatile sweetener that offers numerous health benefits without the downsides of sugar and artificial sweeteners. By debunking these common misconceptions, consumers can make informed choices that contribute to a healthier lifestyle.
Now is the perfect time to reconsider your sweetening choices and embrace the benefits of stevia. With its proven safety, versatility in cooking, and numerous health advantages, stevia stands out as a superior alternative to traditional sugar and artificial sweeteners. Start exploring reputable brands, like Kal Sure Stevia Extract, and experiment with incorporating stevia into your daily routine. By making this simple switch, you can enhance your overall well-being without compromising on taste. Visit your local grocery store or trusted online retailer to find high-quality stevia products and embark on your journey to a healthier, sweeter life today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6605)
Date:
May 24, 2024 04:34 PM
Vitamin C, also known as ascorbic acid, plays an essential role in maintaining overall skin health. This potent nutrient offers numerous benefits, making it a staple ingredient in many skincare products. Below, we explore some of the key advantages of incorporating Vitamin C into your skincare routine.
Collagen is a structural protein that maintains the skin's firmness and elasticity. As we age, collagen production declines, leading to signs of aging such as wrinkles and fine lines. Vitamin C is a crucial co-factor in the synthesis of collagen, helping to keep the skin plump and youthful. Regular application of Vitamin C can stimulate collagen production, making the skin look smoother and more resilient.
Vitamin C's role in collagen production also extends to wound healing. This nutrient supports the repair of damaged skin by promoting new tissue growth. Whether dealing with minor cuts, abrasions, or post-surgical wounds, applying Vitamin C can expedite the healing process and reduce the risk of scarring.
Environmental factors like pollution and UV radiation generate free radicals, molecules that damage skin cells and accelerate aging. Vitamin C is a powerful antioxidant that neutralizes free radicals, protecting the skin from oxidative stress. By incorporating Vitamin C into your skincare routine, you can shield your skin from environmental damage and maintain a healthier complexion.
A robust immune system is vital for overall skin health. Vitamin C bolsters the immune system, making it an essential component of both internal and external treatments. A well-functioning immune system can better fend off skin infections and inflammatory conditions, contributing to clearer, more radiant skin.
Hyperpigmentation occurs when certain areas of the skin produce excess melanin, resulting in dark spots or patches. Vitamin C can inhibit melanin production, helping to lighten Hyperpigmented areas. Over time, consistent use of Vitamin C can promote a more even skin tone, reducing the appearance of age spots, sun spots, and melasma.
One of the most sought-after benefits of Vitamin C is its ability to enhance skin radiance. By improving skin texture and tone, Vitamin C can give your complexion a noticeable glow. Regular use of Vitamin C serums or creams can help achieve a brighter, more luminous look.
Loss of skin elasticity leads to sagging, which is a common sign of aging. By promoting collagen synthesis and offering antioxidant protection, Vitamin C can help maintain the skin's structural integrity. This results in tighter, firmer skin, reducing the likelihood of sagging.
Exposure to environmental pollutants can wreak havoc on your skin, causing premature aging and damage. Vitamin C acts as a protective barrier, reducing the detrimental effects of pollutants. Adding Vitamin C to your skincare regimen helps combat environmental damage, ensuring your skin remains healthy and vibrant.
Maintaining adequate moisture levels is crucial for healthy skin. Vitamin C can support skin hydration by enhancing the skin barrier function and reducing water loss. This ensures that your skin stays supple and well-moisturized, reducing the risk of dryness and irritation.
Vitamin C not only protects against oxidative stress but also aids in repairing the skin. By promoting cell regeneration and improving skin texture, Vitamin C helps to rejuvenate and restore damaged skin.
Ready to experience the transformative benefits of Vitamin C for your skin? Don't wait any longer. Invest in a high-quality Vitamin C serum or cream today and take the first step toward healthier, more radiant skin. Visit our store now to explore our range of Vitamin C products tailored to meet your skincare needs. Enhance your skin's vitality and glow with the power of Vitamin C – your skin will thank you!
Incorporating Vitamin C into your diet is a great way to boost your skin health from within. Here are some excellent food sources of this essential nutrient:
Including these foods in your diet can help ensure you receive adequate Vitamin C, supporting both your overall health and your skin's vitality.
While both food sources and supplements offer ways to meet your daily Vitamin C needs, supplements provide unmatched convenience. Incorporating Vitamin C-rich foods such as oranges, strawberries, and bell peppers into your diet requires careful meal planning and preparation and adds calories to your diet. In contrast, Vitamin C supplements offer a quick and efficient alternative, allowing you to ensure adequate intake regardless of your dietary habits. This convenience makes supplements particularly appealing for busy individuals or those with specific dietary restrictions, enabling them to maintain optimal Vitamin C levels effortlessly.
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Date:
December 07, 2023 12:12 PM
Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that Hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
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Date:
August 10, 2023 10:43 AM
With the growing awareness about the health benefits of green tea, it comes as no surprise that it has become a popular health supplement. One potent green tea supplement that has continued to maintain attention is Natures Answer brand Green Tea Extract in an Alcohol-Free Liquid Extract. Packed with powerful antioxidants, this supplement can aid in digestion, weight management, and overall well-being.
Powerful Antioxidant
Antioxidants are substances that inhibit oxidation, a process that can lead to cellular damage. They act as scavengers, helping shield the body from harmful free radicals, which are unstable molecules that can inflict damage to our cells. This is where green tea, and particularly green tea extract, shines. Rich in antioxidants known as polyphenols, green tea plays a significant role in maintaining the body's overall health. Polyphenols, including flavonoids and catechins, are known for their potent antioxidant effects. The most notable catechin in green tea is Epigallocatechin Gallate (EGCG), widely studied for its powerful impact on health. Green tea's antioxidants help neutralize harmful free radicals, reducing oxidative stress, and subsequently lowering the risk of a host of chronic conditions including heart disease, type 2 diabetes, and even certain cancers. Thus, the antioxidants in green tea aren't just important, they're an integral part of a health-conscious lifestyle.
Boost Immune System
Green tea boosts immunity through its potent bioactive compounds, primarily polyphenols like catechins. These compounds exhibit powerful antioxidant properties, neutralizing harmful free radicals in the body. Additionally, they help increase the body's production of detoxifying enzymes, further enhancing the immune system's efficiency. Green tea also contains a type of catechin called Epigallocatechin Gallate (EGCG), renowned for its immune-boosting properties. EGCG aids in the production of T-cells, the body's first line of defense against infections. Furthermore, green tea fosters beneficial gut bacteria, which play a crucial role in maintaining a robust immune system.
Promotes Weight Loss
Green tea extract works to accelerate weight loss primarily through its active ingredients, one of which is caffeine. Although not as much as coffee, green tea does contain sufficient caffeine that can aid in fat burning and improving exercise performance. More importantly, it is loaded with potent antioxidants called catechins. The most important of these is Epigallocatechin gallate (EGCG), a substance that can boost metabolism. Studies suggest that the combination of EGCG and caffeine in green tea extract can assist in weight loss by helping the body burn more calories, even at rest, and breaking down more fat cells. Additionally, green tea extract is known to increase fat oxidation and improve insulin sensitivity, both beneficial for weight control. While the effects on each individual can vary, when combined with a balanced diet and regular exercise, green tea extract can indeed support and accelerate weight loss efforts.
Impacts Central Nervous System
Green tea extract is known to have profound effects on the central nervous system, primarily due to the presence of caffeine and an amino acid called L-theanine. Caffeine, a known stimulant, works by blocking an inhibitory neurotransmitter in the brain called Adenosine. This increases the firing of neurons and the concentration of neurotransmitters like dopamine and norepinephrine, leading to improved brain function, mood, vigilance, reaction times, and even memory. On the other hand, L-theanine can cross the blood-brain barrier and has been shown to increase the activity of the inhibitory neurotransmitter GABA, which has anti-anxiety effects. It also increases dopamine and the production of alpha waves in the brain. The unique combination of these two compounds in green tea extract is believed to make it an excellent tool for maintaining and enhancing the central nervous system.
Improve Mental Efficiency
Green tea improves mental efficiency through several biological mechanisms. Primarily, it contains caffeine and L-theanine, two compounds known to enhance brain function. Caffeine, a known stimulant, works by blocking an inhibitory neurotransmitter called adenosine, which not only increases the firing of neurons but also amplifies the concentration of other neurotransmitters like dopamine and norepinephrine. This results in improved brain function, vigilance, reaction times, memory recall, and mood.
On the other hand, L-theanine is an amino acid that can cross the blood-brain barrier and has psychoactive properties. It promotes relaxation without drowsiness and can work synergistically with caffeine to enhance brain function. Furthermore, L-theanine increases the frequency of alpha waves in the brain, which leads to improved creativity and problem-solving abilities.
Moreover, green tea is rich in polyphenols and antioxidants, particularly Epigallocatechin Gallate (EGCG), which has protective effects on neurons, potentially lowering the risk of neurodegenerative disorders like Alzheimer's and Parkinson's disease. Hence, regular consumption of green tea or its extract can significantly improve mental efficiency.
Promotes Heart Health
Natures Answer Green Tea Extract Alcohol-Free Extract can help you maintain healthy cholesterol levels, reduce high blood pressure, and prevent blood clot formation that can lead to heart diseases. The polyphenol and catechin compounds in green tea extract are known to promote the health of the heart by reducing inflammation and improving blood vessels' function. Green tea maintains healthy cholesterol levels by inhibiting the absorption of cholesterol in the digestive tract and aiding in its excretion. This leads to a reduced level of LDL (bad cholesterol) in the bloodstream, while not affecting the levels of HDL (good cholesterol). Green tea extract can also lower blood pressure. The catechins it contains help to dilate blood vessels, improving their function and allowing blood to flow more easily. This can lead to a significant reduction in blood pressure, especially in cases of Hypertension.
Furthermore, studies have shown that the antioxidants in green tea can prevent the oxidation of LDL cholesterol, a process that contributes to the formation of plaques in arteries and blood clot formation. By preventing this oxidation, green tea extract can reduce the risk of heart diseases and strokes.
Lastly, the anti-inflammatory nature of green tea's antioxidants helps in reducing inflammation in blood vessels, a condition that can contribute to heart disease. By reducing inflammation, blood flow improves, and the risk of heart disease decreases. In this way, green tea actively promotes heart health.
In conclusion, Natures Answer Green Tea Extract is an all-in-one supplement that can enhance your overall health and well-being in various ways. The antioxidant, anti-inflammatory, and weight management properties of this supplement can do wonders for your physical, neurological, and mental health. Incorporating Natures Answer green tea (alcohol free) liquid extract into your daily routine can help you unlock the multiple benefits that this tea has to offer. So, go ahead, give it a try, and reap the benefits of this powerful supplement!
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Date:
August 04, 2023 02:09 PM
The typical Western diet is largely comprised of processed foods, which are notoriously high in processed table salt. This results in an imbalance in the sodium to potassium ratio, a significant health concern. Sodium is necessary for a variety of bodily functions; however, too much can be detrimental, leading to Hypertension and other cardiovascular diseases. Simultaneously, potassium is often neglected, despite its crucial role in muscle function, nerve signaling, and balancing fluids.
The general dietary advice suggests a potassium to sodium intake ratio of 3:1. However, the reality in diets, particularly those in America, often sees this ratio inverted. The excessive sodium consumption is linked to a myriad of health complications, including high blood pressure and heart disease. Conversely, potassium, a mineral that aids in nerve function and muscle control, is consumed in insufficient quantities. This is a troubling trend that underscores the importance of dietary change towards natural, unprocessed foods.
The importance of potassium is often overshadowed by the emphasis on limiting sodium for reducing chronic disease risk factors. Potassium plays an essential role in maintaining healthy blood pressure levels by counteracting the effects of sodium. Furthermore, the mineral is crucial for other functions like heart and muscle cell functioning, nerve transmission, and maintaining fluid balance.
A study published in the New England Journal of Medicine discovered that individuals with the lowest risk for heart complications or death from any cause were those consuming between four to six grams of sodium per day. This is a fascinating discovery, as this intake is significantly higher than the U.S. daily recommended limits. It suggests a need for a reconsideration of current sodium intake guidelines.
Another consideration to balance the sodium-potassium ratio is the type of salt consumed. Unprocessed, natural salts like sea salt and Himalayan salt contain higher potassium levels compared to standard table salt. These natural salts provide a variety of minerals and trace elements that contribute to our overall health and wellness. It's crucial to note that switching to natural salt should be part of a broader shift towards a diet rich in fresh, unprocessed foods.
Why You Should Focus on Increasing Potassium
While it's beneficial to monitor and moderate sodium intake, it's equally important to shift our focus towards increasing potassium consumption. Potassium-rich foods, such as leafy green vegetables, bananas, potatoes, and beans, not only contribute to a well-rounded and nutritious diet but also help in maintaining an optimal sodium-potassium balance in the body. A high potassium intake can counteract the effects of sodium, aiding in blood pressure regulation and reducing the risk of cardiovascular diseases. Moreover, an elevated potassium level supports various bodily functions, including nerve transmission, muscle contraction, and fluid balance. Thus, prioritizing potassium intake forms a cornerstone for an overall healthier dietary approach. It is recommended that individuals consume 5 grams of potassium daily and potassium to salt ratio should be 2 to 1. To boost potassium intake, one can take a potassium supplement or add the following foods to their diet or both: Watermelon, Orange juice, Boiled red potatoes, Avocado, Bananas, Cantaloupe, Oranges, Coconut water, Tomatoes, Yogurt, Winter squash, and Wild-caught salmon.
Why Low-Salt Advice Can Be Harmful
Contrary to popular belief, adhering to low-salt advice can sometimes pose risks to certain individuals. While it is true that excessive sodium intake can lead to high blood pressure and heart problems, sodium still plays a vital role in our bodies. It assists in nerve conduction, muscle contraction, and maintaining the body's fluid balance.
In fact, low sodium levels in the body, a condition known as hyponatremia, can lead to symptoms such as headache, nausea, fatigue, and in severe cases, coma or even death. Moreover, a low-salt diet may lead to increased levels of cholesterol and triglycerides, hormonal imbalances and insulin resistance. This can potentially elevate the risk of developing cardiovascular disease.
Low-salt diets can also exacerbate the risk of certain health conditions. For instance, individuals with conditions like Addison's disease or certain kidney disorders, where the body struggles to maintain a balance of electrolytes, might find a low-salt diet harmful.
Therefore, it is crucial to balance the intake of sodium, considering both the potential risks associated with too much, or too little, sodium. The key is to consume sodium from natural and unprocessed sources, such as Himalayan salt, fruits, vegetables, grains, and lean meats, which also provide a host of other nutrients necessary for overall health. As with most things in nutrition, moderation and balance seem to hold the answer rather than extreme restriction. The RDA - recommended daily allowance of sodium is 3.5 grams. It is advised to consume 3.5 grams of natural salt each day by way of foods or combination of foods plus Himalayan salt to reach that goal.
The Impact of Excessive Salt Intake on Certain Health Conditions
While moderate salt intake is vital for normal physiological functions, its excessive consumption can have detrimental effects, particularly for individuals with certain health conditions. For instance, endocrine disorders, high aldosterone levels, Cushing's syndrome, and elevated cortisol levels can all heighten the body's sensitivity to sodium, making it even more essential to monitor and limit salt intake.
Endocrine disorders, which involve imbalances in the body's hormone production, can often lead to increased sodium retention, exacerbating issues of water retention and swelling. Similarly, high aldosterone levels, a hormone that regulates sodium and potassium balance, can cause the body to retain excessive sodium, leading to high blood pressure and potential damage to the cardiovascular system.
Cushing's syndrome, a condition characterized by excessive cortisol production, can lead to a host of symptoms, including high blood pressure and rapid weight gain, both of which can be intensified by high sodium intake. The excessive cortisol found in Cushing's syndrome promotes sodium retention, further elevating the risk for Hypertension.
Similarly, elevated cortisol levels, even outside of Cushing's syndrome, can lead to heightened sodium retention, contributing to high blood pressure, fluid retention, and an imbalance of electrolytes. Therefore, individuals with these conditions should be particularly mindful of their sodium intake.
In these scenarios, reducing salt consumption can help mitigate the associated health risks and symptoms. Switching to a diet rich in whole, unprocessed foods, and taking conscious steps to limit the use of added table salt can play a crucial role in managing these health conditions. As always, it is essential to seek personalized advice from a healthcare professional, as individual needs may vary.
In summary, while salt is often villainized in the health community, its consumption, especially from natural sources, is vital for maintaining bodily functions like nerve conduction, muscle contraction, and fluid balance. However, excessive or inadequate sodium intake can have adverse health effects, such as Hypertension, imbalances in cholesterol and triglycerides, and even hyponatremia in severe cases. Certain health conditions, including endocrine disorders, high aldosterone levels, Cushing's syndrome, and elevated cortisol levels, can also exacerbate these risks, making it crucial for individuals with these conditions to carefully monitor their salt intake. On the other hand, increasing potassium intake can help maintain an optimal sodium-potassium balance, reducing blood pressure and lowering the risk of cardiovascular diseases. In a nutshell, moderation and balance are key in sodium consumption, but the emphasis should be on consuming more potassium-rich foods to ensure your potassium intake is higher than sodium levels which will ensure a healthier dietary approach.
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Date:
April 27, 2022 11:53 AM
Did you know that N Acetyl Cysteine has been around for decades? This powerful supplement was first discovered in the 1950s and has been used as a remedy for many health issues since then. We will discuss the many benefits of N Acetyl Cysteine and how you can start using it to improve your health!
Glutathione and aging
As we age, our natural levels of glutathione tend to decline. This is a major cause of many of the negative effects associated with the aging process, including reduced energy and slower recovery times after illness or injury. Fortunately, there are steps that we can take to increase our levels of glutathione, thus slowing down the aging process and keeping us feeling young and vibrant for longer. Some of these steps include eating a healthy diet rich in antioxidant-rich foods like fruits and vegetables, engaging in regular physical activity to improve circulation, and reducing stress levels through relaxation techniques like yoga and meditation. With these strategies in place, we can help to keep our bodies strong, boost our energy levels, and stay young well into old age. Fortunately, there is a supplement that could help, it is called N Acetyl Cysteine, this substance is a precursor to Glutathione and has been shown to boost glutathione levels.
What is N Acetyl Cysteine and what are its benefits?
N acetyl cysteine has been used as a supplement for many years, and its popularity is likely due to the many benefits it offers. The main function of this compound is to promote the production of glutathione, a powerful antioxidant that protects our bodies from oxidative stress and harmful free radicals. In addition, n acetyl cysteine has been shown to help reduce symptoms of certain mental health disorders, including anxiety and depression. Furthermore, studies have found that n acetyl cysteine may lower blood pressure and improve heart health by increasing blood flow and improving blood vessel function. Overall, it is clear that n acetyl cysteine has been an effective nutrient for many years and continues to be widely used by those looking for an easy way to support their health.
How can you start using N Acetyl Cysteine to improve your health?
N acetyl cysteine (NAC) is a powerful antioxidant that can help to protect cells from damage. It has been shown to be particularly effective in guarding against liver damage, and is often used as a treatment for hepatitis C. NAC can also help to improve lung function and relieve respiratory conditions such as bronchitis and asthma. In addition, NAC has been shown to boost levels of glutathione, which is a key molecule involved in detoxification. As a result, NAC can help to cleanse the body of harmful toxins and pollutants. NAC is available in supplement form, and can be taken orally or intravenously. It is generally well tolerated, with mild side effects such as nausea and vomiting occasionally reported. When taking NAC supplements, it is important to start with a lower dose and increase gradually as tolerated. Those with pre-existing medical conditions should always speak to their doctor before taking any new supplement. Overall, NAC is a safe and effective way to improve your health and protect your cells from damage.
What is the recommended daily dosage for N Acetyl Cysteine per day?
The standard recommended dosage for N-acetyl cysteine (NAC) is 600 mg per day. However, some studies have used dosages as high as 2,400 mg per day. The most common side effect of NAC is nausea, which can be minimized by taking the supplement with food. NAC is also sometimes used as a treatment for chronic bronchitis, and the recommended dosage for this condition is 1,200 mg per day. When used for this purpose, NAC is typically taken in divided doses of 600 mg twice per day. There is currently no consensus on the optimal dosage of NAC for any particular condition, and further research is needed to determine the ideal dosage for different applications. In acute circumstances, one might need 4000mg to 6000mgs daily in divided dosages, always work your way up to higher dosages as needed.
What are some of the most common uses for this supplement?
There are many different uses for NAC, or N-acetyl cysteine. This potent antioxidant supplement has been found to be effective in addressing a wide range of health concerns, including asthma and COPD, chronic sinusitis, liver disease, and particularly serious conditions such as cancer. Additionally, NAC has been shown to provide support for the immune system in general and may also serve as a detoxifying agent by helping to eliminate waste products like heavy metals from the body. Overall, there are numerous benefits to using NAC as part of a well-balanced diet. Whether you are looking to improve your respiratory health or strengthen your immune system, this versatile supplement can help you achieve your goals.
NAC composition
NAC, or N-acetyl cysteine, is a complex compound that is composed of various amino acids, including glutamate, glycine, and cysteine. These specific amino acids all play important roles in the function of NAC and affect its many beneficial properties. For example, glutamate increases metabolism and energy levels, while glycine promotes tissue healing and regeneration. Cysteine, on the other hand, facilitates the transport of oxygen and serves as a natural antioxidant. When taken together, these different components work synergistically to promote overall health and wellbeing by supporting key physiological processes such as digestion and immune response. Whether taken as a supplement or consumed through food sources like eggs and milk products, NAC is a versatile substance that is vital to many aspects of our daily health and well-being.
NAC and liver health
N-Acetyl-Cysteine (NAC) is a compound that has numerous benefits for liver health. Studies have shown that NAC can help to protect the liver from damage caused by alcohol and other toxins. It does this by helping to replenish levels of glutathione, a key antioxidant that helps to detoxify the liver. NAC also helps to reduce inflammation and improve blood flow to the liver. As a result, it can be an effective treatment for both acute and chronic Liver diseases. In addition, NAC has been shown to improve the overall health of people with Liver cirrhosis. Consequently, N-Acetyl-Cysteine is a compound that has many benefits for liver health and should be considered as part of any comprehensive treatment plan.
NAC, its sulfur content, and mucus elimination
NAC, or N-acetyl cysteine, is a sulfur-containing amino acid that plays an important role in mucus production and elimination. The sulfur content of NAC helps to thin mucus and make it less sticky, making it easier to clear from the lungs. In addition, NAC helps to break down mucus and remove it from the body. As a result, NAC is often used as a supplement to treat respiratory conditions such as bronchitis and chronic obstructive pulmonary disease (COPD). NAC is typically taken in the form of capsules or tablets, and the recommended dose depends on the individual. However, side effects are rare and generally mild, making NAC a safe and effective option for those seeking to improve their respiratory health.
N Acetyl Cysteine may lower blood pressure
One of these is its ability to lower blood pressure. A review of several studies found that N-acetyl cysteine was effective at reducing blood pressure in people with Hypertension. In one study, participants who took N-acetyl cysteine had an average reduction in systolic blood pressure of 9.5 mmHg, compared to those who took a placebo. Other studies have shown similar results, suggesting that N-acetyl cysteine may be an effective treatment for high blood pressure. While more research is needed to confirm these findings, N-acetyl cysteine may offer a safe and natural way to lower blood pressure.
N Acetyl Cysteine may help blood clots - thrombosis
Blood clots are a necessary part of the body's natural healing process. They help to stop bleeding by sealing off damaged blood vessels. However, sometimes blood clots can form in healthy blood vessels, causing a potentially deadly condition called thrombosis. N Acetyl Cysteine is a compound that helps to break up blood clots and prevent thrombosis. It works by preventing the formation of a protein that is essential for clotting. In addition, N Acetyl Cysteine helps to improve the flexibility of blood vessels, making them less likely to rupture. As a result, this compound may help to reduce the risk of thrombosis and improve overall cardiovascular health.
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Date:
September 04, 2020 11:05 AM
Many people turn to over the counter (OTC) drugs when they experience pain, the common ones are non-steroidal anti-inflammatory drugs, better known as NSAIDS. The problem with NSAIDS these drugs reduce an enzyme associated with pain called COX-1 and COX-2. There are a lot of hidden dangers behind prescription and OTC pain killers. Some of the most common ones consumed are Ibuprofen an d Acetaminophen.
Ibuprofen: a popular OTC pain reliever can cause stomach pain, nausea, gastric bleeding, ulcers, confusion, Hypertension, increased heart attack and stroke. Also, swelling, rapid weight gain, reduced urination, which is a sign of kidney dysfunction, kidney failure, fever, sore throat, headache, rash, bruising, tingling, numbness, muscle weakness, neck stiffness, chills, light sensitivity, and seizures.
Acetaminophen: also known as Tylenol, is classified as an NSAID, but is also unsafe. The number one cause of liver failure in the United States is caused by acetaminophen next to alcohol consumption. If combined with alcohol, the damage to the liver is increased significantly. It also depletes glutathione, an important antioxidant needed by the liver to protect and detoxify the body. Over use of this OTC drug can cause nausea, vomiting, abdominal tenderness, and it can interfere with blood clotting, weaken kidney function, and with severe over dose can cause death.
The alternative: Curcumin is a safe and effective pain reliever
Curcumin is a compound from Turmeric Root, unstandardized turmeric powder contains only two to three percent curcumin. It is important to get a standardized curcumin so that you can get a therapeutic response from consuming this herb. Not all curcumin is the same, look for a brand that blends turmeric essential oil with curcumin to enhance the absorption of the product because the product is hard to absorb.
Curcumin is one of the worlds best studied herbs, it works by reducing a COX-2 response to inflammation the same target as many prescription and OTC drugs that cause organ damage and side effects. Fortunately, Curcumin can target the same in a safe and natural way with no side effects. It can prevent a wide spectrum of inflammatory and oxidative damage, relieve chronic pain as effective and much more safely than drugs like NSAIDs.
Taking OTC or prescription pain relieving drugs are not a long term solution for pain. With the side effects associated with common pain relievers, one should only take them as a last resort and consider using a safer alternative that is as effective to relieving pain. Terry Naturally offers BCM-95 a patented curcumin that is blended with turmeric essential oils, BCM-95 has been the subject of many clinical studies demonstrating its effectiveness in relieving pain. We at VitaNet offer free shipping on any product in Terry’s brand. If you are struggling with pain, consider trying Terry Naturally to help relieve pain safely.
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Date:
May 17, 2019 04:03 PM
Up to a billion people worldwide may not be getting enough vitamin D, and this is a real problem because vitamin D deficiency can increase the risk of cancer, obesity and other health problems. Meta-analysis published by Current Pharmaceutical Design suggests that getting enough vitamin D can decrease fasting glucose and reduce insulin resistance. Vitamin D can also help moderate your bad cholesterol, as well as reducing your levels of C-reactive protein, which is a sign of inflammation. Key Takeaways: "Three of the most significant risk factors for heart disease are high cholesterol, chronic inflammation, and insulin resistance. Researchers wanted to learn more about whether vitamin D supplementation is a way to lower the risk of heart disease or reduce complications in patients who already have it." Read more: https://www.naturalhealth365.com/vitamin-d-glycemic-control-2947.html
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Date:
May 14, 2019 04:11 PM
Researchers recommend men having erectile dysfunction to be taking diets and supplements rich in zinc. This is because it has been discovered that the element can improve the proper functioning of the penis. Erectile dysfunction comes about when a man is unable to have and sustain an erection. It is often attributable to chronic health problems like hypertension or a consequence of stress disorders like depression. The treatment for erectile dysfunction takes two conventional approaches. One approach is to concentrate on the health issue that caused the problem. But the drawback of this approach is that it takes time and effort. The other approach is using drugs that will help to start and sustain an erection. One of such drugs is Viagra. The drawback of approaches using drugs is that these drugs can have unwanted side effects. But natural supplements such as horny goat weed and vitamin D supplements have also been found effective in treating erectile dysfunction. It has been found that people who are deficient in zinc are more prone to changes in their physiology and can easily get erectile dysfunction. It can also result in weakening of the immune system. That is why zinc is recommended for the treatment of erectile dysfunction. By the way, it is low risk and high reward form of treatment. Key Takeaways: "It is often a secondary effect of either chronic health problems like hypertension or stress disorders such as depression." Read more: https://www.naturalnews.com/2019-04-16-zinc-supplementation-can-benefit-individuals-with-erectile-dysfunction.html
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Date:
May 10, 2019 02:20 PM
Astragalus is known in Chinese medicine because it has been used by the Chinese for centuries as a medicinal herb. Recent researchers have backed up the healing claims of the plant. In a new study that was done in China, Chinese researchers have discovered that polysaccharide extracts from astragalus can be effective against pulmonary arterial hypertension. To carry out the study they fed rats with monocrotaline in order to induce pulmonary arterial hypertension in them. Then they gave the rats 200 milligrams per kilogram of astragalus polysaccharides once in every two days for a period of two weeks. The results were positive. It was found that the polysaccharides of astragalus reduced the hypertension of the pulmonary artery induced by monocrotaline in rats. There were other benefits that were discovered. The treatment with the polysaccharide of astragalus also eliminated oxidative stress, promoted vasodilation, and reduced inflammation in the rats. All these suggest that astragalus lowers the blood pressure in individuals. The findings of the study were then published in the American Journal of Chinese Medicine with the authors stating that astragalus can be used to eliminate symptoms of pulmonary arterial hypertension in individuals. Key Takeaways: "In China, astragalus is one of the herbs commonly prescribed to help with diabetes management. Research has also shown that the active compounds in astragalus may help in reducing blood sugar levels in people with Type 2 diabetes. Lab trials have shown that it improves metabolism, reduce blood sugar levels, and aid in weight loss." Read more: https://www.naturalnews.com/2019-04-17-astragalus-improves-symptoms-of-pulmonary-arterial-hypertension.html Even CBD can help reduce hypertension.
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Date:
May 07, 2019 01:58 PM
Irritable bowel syndrome (IBS) doesn't just cause uncomfortable digestive symptoms, but it also can result in intestinal hyper-permeability, which decreases the rate in which your body can absorb vitamins and nutrients that are required to thrive. An amino acid called glutamine can help by reducing the rate in which intestinal hyper-permeability occurs, allowing your system to absorb primary nutrients in a much more effective manner. It also showed to reduce the symptoms of IBS all-around. Key Takeaways: "In the quest to find natural solutions for IBS or digestive upset, adding a glutamine supplement to a well-balanced diet could be the next key step." Read more: https://www.naturalhealth365.com/glutamine-gut-health-2785.html
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Date:
May 02, 2019 02:45 PM
A team of researchers from the Middle East have found that a species of hawthorn, Crete hawthorn, has the ability to lower elevated levels of glucose in the blood. They have published their findings in the journal BMC Complementary and Alternative Medicine. Along with its effects on blood glucose, called its anti-hyperglycemic property, it also has hyperlipidemic properties, that is, the ability to protect the body against high levels of fat such as cholesterol in the blood. They carried out the study using mice that were induced with hyperglycemia through feeding them alloxan. The mice were then divided into two groups, one group receiving Crete hawthorn extracts and the other given a chemical for control. They also used another animal model to understand its hyperlipidemic properties and to investigate whether the plant had antioxidant and antimicrobial properties. The results of the findings were that Crete hawthorn had important antioxidant properties due to its containing phenols and flavonoids. They also found that it had antimicrobial properties because it acted against bacteria such as E. Coli and Staphylococcus aureus, among others. Key Takeaways: "The mice were then divided into groups, with some receiving an ethanol extract from Crete hawthorn leaves while others were given glibenclamide for positive control." Read more: https://www.naturalnews.com/2019-03-12-hawthorn-controls-high-blood-sugar-levels.html
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Date:
May 02, 2019 01:59 PM
Autoimmune diseases affect nearly 50 million people living in the United States. These diseases can lead to either over-activation, where antibodies may attack otherwise healthy organs, or under-activation, where not enough antibodies are produced to effectively fight off diseases. Using cannabis may be an alternative means of dealing with autoimmune disorders. Cannabinoids have been shown to be able to bind to receptors within the body which appears to be a possible therapeutic key. Studies with hepatitis, psoriasis, fibromyalgia, Crohn's disease, and Multiple Sclerosis have shown cannabis to provide some relief. However, there are some risk of discomfort from side-effects that could occur with using cannabis to treat autoimmune diseases. Key Takeaways: "In cases of over-activation, the immune system produces antibodies in response to an unknown trigger that attacks the body's own tissues and organs." Read more: https://news.weedmaps.com/2019/03/how-can-cannabis-help-with-autoimmune-disorders/
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Date:
April 30, 2019 09:28 AM
Vitamin D has a wide range of vital health benefits for your bones, teeth, heart and endocrine system. Recent research suggests it also has a critical job in brain health and mental health as as well. Vitamin D deficiency — already associated with damage to the immune system and hypertension — may also put you at a higher risk of schizophrenia or cognitive impairment. This is a serious problem, given that there may be a billion vitamin D-deficient people in the world today. Key Takeaways: "New research finds that vitamin D deficiency influences a kind of brain “scaffolding” that supports the neurons." Read more: https://thestylishmagazine.com/1469/vitamin-d-and-its-effect-on-brain/
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Date:
April 26, 2019 03:15 PM
It is common knowledge that omega-3s can promote heart health, but now studies are showing that they can also help children who are suffering from behavioral disorders. A study was published within the Journal of Dietary Supplements that showed kids aged six to twelve showed great improvement in regards to their overall health status and quality of life when they were given doses of omega-3s on a regular basis. The study evaluated exactly 942 children, so the findings are quite consistent. Key Takeaways: "To evaluate the effectiveness of omega-3 fatty acid supplementation, the researchers used the Kidscreen-10 and the Strengths and Difficulties Questionnaires (SDQ). The SDQ examines 25 positive and negative attributes, which are divided among five scales: emotional symptoms, conduct problems, hyperactivity or inattention, peer relationship problems, and prosocial behavior." Read more: https://www.naturalnews.com/2019-03-17-omega-3-benefits-children-with-behavioral-disorders.html
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Date:
April 24, 2019 01:58 PM
A recent study took pregnant rats who were suffering from gestational diabetes, and they gave them propolis to see if it had a beneficial impact on regulating their glucose levels. The results showed that propolis did, in fact, help regulate blood sugars, and it also helps in several other areas as well. Taking propolis consistently can also help protect you against hypertension during your pregnancy, as well as promote faster wound healing which is extremely important in diabetic patients. Key Takeaways: "Their study, which was published in BMC Complementary and Alternative Medicine, showed that the superfood propolis not only improves pregnancy outcomes but also placental oxidative stress." Read more: https://www.naturalnews.com/2019-02-26-diabetic-pregnant-women-should-take-propolis.html
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Date:
April 17, 2019 01:45 PM
Chances are, you or someone you love has dealt with the ramifications of cardiovascular disease (CVD) in some way. While there may not be any way to completely safeguard you and your loved ones from early mortality due to CVD, research is now showing that fiber consumption may play a promising role. A recent study showed that those who consume more fiber are much less likely to face an early demise due to the presence of CVD. Key Takeaways: "A study reports that having a fiber-rich diet lowers the risk of contracting chronic CVDs and Type 2 diabetes, as well as some cancers and inflammatory diseases like rheumatism." Read more: https://www.naturalnews.com/2019-02-27-fiber-reduces-inflammation-reducing-risk-of-inflammatory-diseases-and-the-rate-of-mortality.html CBD can reduce inflammation and east pain through out the body as well!
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Date:
April 16, 2019 10:53 AM
Metabolic syndrome involves a combination of at least three out of five conditions — hypertension, abdominal obesity, low “good cholesterol,” and excessively high fasting blood glucose and serum triglyceride scores. Metabolic syndrome is a major public health concern, given that more than a third of American adults have it. Recent studies suggest that eating too much saturated fat can imbalance the bacteria in the gut. This results over time in oxidative stress and inflammation that can deplete the body’s stockpiles of vitamins C and E, and also make it harder to absorb more vitamin C from food to replace what has been used up. Vitamins C and E play an important role in protecting against oxidative stress. Key Takeaways: "Around 35% of the American adult population has metabolic syndrome, with a higher prevalence in older age groups." Read more: https://www.medicalnewsbulletin.com/poor-gut-health-vitamin-c-e-metabolic-syndrome/
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Date:
April 12, 2019 04:02 PM
Researchers from around the world will convene in Australia, sharing the newest research on Vitamin C. Controversy precedes the gathering, with opposing claims on vitamin C’s effectiveness in treating cancer. This debate harkens back to research conducted in the 1970’s, but the results of recent trial might sway naysayers; it reported an 80% mortality reduction rate for those suffering from sepsis. Supporters from University of Otago claim that vitamin C’s hype has been largely ignored in the past, but more and more studies garner its support. Opposition from the same school submit the gathering evidence is substantial, but more research must be conducted. Key Takeaways: "Alongside traditional treatments, patients with septic shock are being given intravenous doses of vitamin C, totalling about 7g a day." Read more: https://www.stuff.co.nz/national/health/110559685/vitamin-c-research-booming-emerging-evidence-promising
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Date:
February 22, 2019 08:54 AM
There has now been a new recipe developed that has the ability to reduce blood glucose levels in those looking for a way to keep their sugar levels in balance. The recipe is quite simple, and the ingredients are likely already in your pantry ready for use. Just take one lemon, some ginger, and one full liter of water. Chop both the lemon and ginger into boiling water so that it can absorb all of the nutrients. Key Takeaways: "If the analysis shows the 70-90 milligrams before meal - your blood sugar levels are normal." Read more: https://www.legit.ng/1215271-can-ginger-turmeric-lemon-juice-reduce-blood-sugar.html
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Date:
February 20, 2019 01:17 PM
The thyroid, a small gland at the base of the neck, receives TSH from the pituitary gland. This relationship, whether too active or not active enough, causes many adverse side effects. Too much TSH (hyperthyroidism) can cause: weight loss, cardiovascular irregularities, nervousness, and etc. Too little TSH (hypothyroidism) causes symptoms like: depression, impaired memory, hoarseness, fatigue, weight gain, etc. Currently, no cure exists for either of these conditions, other than individual specific diets targeted at raising or lower TSH levels. As always, one should consult a doctor and get proper blood work done before making any major life changes. Key Takeaways: "Thyroid problems can affect anyone of any age from infancy to the latest years of life." Read more: https://draxe.com/hyperthyroidism-vs-hypothyroidism/
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Date:
February 15, 2019 10:25 AM
Blood pressure, that one health problem you always hear about but really don’t have that much knowledge on. In a new study, research published by the journal of hypertension shows that black seed may be a potential aid in helping lower that blood pressure. The article reviews the basics of the study and provides you with uses and common ways to find black seed. It additionally provides you with a few extra foods that can help lower your blood pressure overall. Key Takeaways: "Ten of these RCTs compared black seed with placebo and one compared black seed with standard treatment. They also looked at the associations between blood pressure reduction and the duration of treatment, dosage of black seed, and type of black seed." Read more: https://www.naturalnews.com/2019-02-10-systematic-review-studies-the-potential-of-black-seed-in-lowering-blood-pressure.html
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Date:
January 27, 2019 04:33 PM
Vegan diets are something that is really in fashion right now. Years ago, very few people were following vegan diets. People did not pay much attention to it but now, due to social media and marketing, these diets are getting more and more hype. As a result, you should try to make sure you are getting all the nutrients you need when on this diet. It is only natural for there to be some kind of nutrient deficiency when on this sort of meal plan. Key Takeaways: "Following a vegetarian or (the stricter) vegan lifestyle is rewarding, but it also comes with some challenges. Foregoing meat means you lose out on a major source of protein, but the list below includes other Paleo meat-free sources of this crucial nutrient." Read more: https://www.naturalnews.com/2018-12-08-best-vegan-friendly-protein-sources.html
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Date:
January 24, 2019 09:10 AM
There are plenty of things out there that help fight off infection. Many people feel as if medicine is still the best thing to have when you are facing certain sicknesses. They are reliable and have been used for many years. However, there are some people who feel as if medicine is outplayed and does not actually work. These new natural antibiotics are getting a lot of hype in the world of medicine due to the positive feedback they have received. Key Takeaways: "Instead of taking antibiotics, which are linked to negative side effects, take this DIY natural antibiotic to recover from a cold or a bacterial infection." Read more: https://www.naturalnews.com/2018-12-06-natural-antibiotics-that-help-fight-off-infection.html
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Date:
January 21, 2019 01:40 PM
Cannabis is something that many people have heard of. However, it is not something that is very commonly mentioned in food circles. Sure, we all know that cannabis is very prevalent in the communities who smoke a lot of marijuana. These communities love cannabis and what it brings them. However, there are studies being done that show that cannabis can be a real life super food. With that, it has some use cases that can be good for one's health. Key Takeaways: "Cannabis' nutritional properties have been gaining traction as its popularity grows" Read more: https://lfpress.com/cannabis-culture/top-three-reasons-why-cannabis-is-a-powerful-superfood/wcm/87ee82e3-1458-43de-8856-447c44198bbd
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Date:
January 18, 2019 09:05 AM
Many people experience a chance in their body as they get older. It is natural and it happens over a longer period of time. Some people deal with it better than others but the truth of the matter is that there are ways to combat issues that come on to people. In regards to inflammation, this is an issue commonly seen in modern times. It is really hard for some to deal with it but papayas is something that is getting a lot of hype in the medicinal world as a way to treat this problem. Key Takeaways: "Papayas are commonly used in traditional medicine. However, due to recent discoveries about their various health benefits, modern pharmaceutical industries have decided to look into the possible medicinal applications of the papaya." Read more: https://www.naturalnews.com/2018-12-06-papayas-can-be-used-to-reduce-inflammation-in-your-body.html
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Date:
January 16, 2019 07:55 AM
The things that you put on your skin enter the bloodstream, so it is important to carefully think about the things that you'll use in your skin care regimen. One oil that can be applied to the skin that will benefit you when it is absorbed is rosehip. The powerful oil can enhance your skin in a plethora of ways and dermatologists agree that it is a product that people of all ages should use to keep their skin smooth, wrinkle-free, and looking great. Key Takeaways: "Here, exactly how rosehip oil benefits your skin and the easiest way to add it to your beauty routine." Read more: https://www.prevention.com/beauty/skin-care/a25596857/rosehip-oil-benefits/
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Date:
January 10, 2019 05:00 PM
Both diabetes and routine engagement in tobacco smoking can raise the risk of cardiovascular damage due to a rise in oxidative stress. While curcumin isn't proven to completely diminish the amount of oxidative stress that is caused as a result of diabetic and tobacco consumption symptoms, it does greatly decrease the amount of oxidative stress that is experienced by each individual which naturally results in the heart being less vulnerable. It is also known to specifically reduce the amount of hyperglycemia-induced oxidative stress. Key Takeaways: "For the study, the researchers administered nicotine to diabetic rats to determine the effect of the combined oxidative stress of diabetes and nicotine." Read more: https://www.naturalnews.com/2019-01-02-curcumin-protects-heart-from-damage-by-diabetes-and-smoking.html
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Date:
January 08, 2019 09:58 AM
According to the Journal of Ayurveda and Integrative Medicine, Arjun Tree extract may have benefits for moderating your blood sugar and also your cholesterol levels. Diabetics are at dramatically higher risk of dying from heart conditions, perhaps because hyperglycemia tends to raise blood pressure and damage the circulatory system. The study in question focused on Wistar rats that received a high-fat diet, and found that Arjun Tree extract improved insulin sensitivity and liver triglycerides, and exhibited a pronounced anti inflammatory effect. Key Takeaways: "In this study, which was published in the Journal of Ayurveda and Integrative Medicine, the researchers were able to determine that Arjun tree extracts exhibit anti-hyperglycemic and anti-hyperlipidemic activity." Read more: https://www.naturalnews.com/2018-12-24-arjun-tree-lowers-blood-sugar-and-cholesterol-levels.html
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Date:
January 07, 2019 03:55 PM
Patients who are diabetic or engage in tobacco smoking can unfortunately face health concerns in regards to oxidative stress that impacts their cardiovascular function. A lot of this oxidative stress is referred to as hyperglycemia-induced, and it is shown to be less prevalent when curcumin is consumed. In one particular study, the administration of the curcumin actually prevented the oxidative stress due to diabetes and tobacco smoking altogether. This could show great promise for those struggling with insulin levels and tobacco addiction. Key Takeaways: "Research has found that curcumin can protect cardiac tissues from the combined oxidative stress induced by diabetes and nicotine." Read more: https://www.naturalnews.com/2018-12-20-curcumin-protects-cardiac-tissue-from-combined-oxidative-stress-induced-by-diabetes-and-nicotine.html
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Date:
January 07, 2019 03:36 PM
One of the main chemicals in mulberry fruit is rosiglitazone, and studies are showing that mice given rosiglitazone had much lower insulin readings than those who were not given the substance. The mulberry fruit was able to accomplish this by improving the amount of a certain chemical called 'plasma membrane-glucose transporter 4'. This is what helps plasma enter the skeletal muscles. They think that this could potentially provide relief to those suffering from Hyperglycemia or insulin resistance. Key Takeaways: "The researchers constructed an animal model with a strain of mice that simulated the symptoms of diabetes in humans. The lab animals were divided into three groups according to the treatment they received." Read more: https://www.naturalnews.com/2018-12-18-mulberry-fruit-extract-on-insulin-sensitivity.html
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Date:
December 12, 2018 09:09 AM
Okra water is one of those things that is getting a lot of hype right now. People are talking about it and really feel as if it better than the typical water that you would get in the store. First and foremost, Okra water is rich in fiber. If you have a deficiency in this area, this kind of water can help solve that for you. Also, it is now possible for you to make your own Okra water at home. Key Takeaways: "A 2015 study published in Nutrients found that, in combination with daily physical activity, adding okra to your diet can enable you to exercise longer without tiring as quickly and recover faster." Read more: https://www.healthnutnews.com/4-health-benefits-of-drinking-okra-water-and-how-to-make-your-own-at-home/
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Date:
December 10, 2018 04:11 PM
Many people around the world are skeptical about the actual use case of a so called super food. These things are supposed to be foods that offer excellent health benefits. Health gurus around the world that specialize in dieting feel as if these things are so important for the future. For example, spirulina is one of these foods that is getting a lot of hype. It is very rich in protein but its main benefit is that it can greatly help immunity. Key Takeaways: "One of the biggest benefits associated with spirulina is its ability to boost immunity." Read more: https://www.naturalnews.com/2018-11-21-do-rumored-spirulina-benefits-stand-up-scrutiny-of-science.html
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Date:
December 08, 2018 11:16 AM
Plant remedies around world are getting more and more attention. People are realizing that there is a very high use case for these things and it is being accepted around the world. Gotu Kola is a planet remedy that is common due to its usefulness for various different things that are found in people. At the end of the day, not all plant remedies will work for everyone. However, if you find one that does work for you, it can work wonders. Key Takeaways: "Psychoactive substances target the brain and nervous system, resulting to an altered mental state. This psychoactive property is the reason why Gotu Kola is traditionally used for enhancing memory, longevity and cognition. In addition to these, Gotu Kola has also been used to treat skin conditions, including leprosy, lupus, varicose ulcers, eczema, psoriasis." Read more: https://www.naturalnews.com/2018-11-22-gotu-kola-in-ayurvedic-medicine.html
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Date:
November 21, 2018 09:57 AM
There are a lot of people out there that struggle with high blood pressure. It is a real problem that affects many people in the world and the people who do not have to worry about it are very lucky. Now, there have always been a couple of set ways to combat high blood pressure. However, now doctors are saying that fiber, and the intake of more of it, can be the key to reduce Hypertension and high blood pressure. Key Takeaways: "The best diet to reduce high blood pressure happens to contain plenty of foods high in fiber." Read more: https://www.cheatsheet.com/health-fitness/does-fiber-lower-high-blood-pressure-what-to-eat-to-reduce-Hypertension.html/
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Date:
November 10, 2018 09:51 AM
Diabetes is a serious and chronic condition, which as it progresses can wreak havoc on an array of bodily systems. One potential victim of the havoc is the kidneys. They endure a great deal of oxidative stress in a body that is constantly fighting the effects of diabetes. This ongoing stress overtime does damage the kidneys and can eventually destroy them The condition of oxidative stress endured by kidneys functioning under an ongoing onslaught of diabetic effects is known as diabetic nephropathy. In a worse case scenario it can lead to total renal failure. The organic tuber, Indian Kudzu, is an Aryuvedic medicine staple, besides housing a wealth of antioxidants. Researchers from a Banaras Hindu University recently decided see whether the oxidative power of Indian Kudzu might be able to stand tall against the stress endured by kidneys undergoing diabetic onslaught, thereby protecting them from the ravages of the stress. The study, which used rodent subjects, proved that though oxidative stress in the diabetic rodent subjects was high, the kudzu was able to reduce or reverse some of the damage, due in part to its ability to improve human antioxidant enzyme activity. Key Takeaways: "The tubers are a treasure trove of antioxidants that reduce the effects of oxidative stress and reactive oxygen species related to aging and various ailments." Read more: https://www.naturalnews.com/2018-11-06-indian-kudzu-for-diabetics-it-keeps-kidneys-healthy.html
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Date:
November 03, 2018 02:51 PM
What happens when a person has too much melanin? Their nails and skin darkens considerable in a condition called hyperpigmentation. The good news is that you can treat the condition naturally with licorice extract which is made by mixing ten parts of distilled water mixed with a part of extract. Put the mixture on a towel and use it as a compress for about ten to fifteen minutes twice a day. Moisturize your skin afterward with lotion so it doesn't dry out. Key Takeaways: "Licorice extract is often combined with different citrus fruits to make an effective skin brightener." Read more: https://www.naturalnews.com/2018-10-12-licorice-extract-is-a-safe-and-natural-remedy-for-hyperpigmentation.html
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Date:
November 03, 2018 02:51 PM
There are a lot of people out there who know a little bit about the gut. A gut is something that actually has a lot of use cases for the human body. Some people understand that while other people think that is completely crazy. Depending on who you are and what you have seen, you will have your own opinion on this. Whether you believe it or not, the things you consume get stored within your gut. Key Takeaways: "With 60 to 80 percent of the immune system being housed in the gut, when something in the digestive system gets out of whack—whether we recognize it as a gut issue or not—problems will emerge." Read more: https://www.thriveglobal.com/stories/46594-why-all-the-hype-about-gut-health
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Date:
October 10, 2018 03:26 PM
The probiotic Bifidobacterium lactis, or B. lactis, is a powerhouse for gut health. Why is this strain of bacteria so important? One study published in 2015 showed that B. lactis could improve unpleasant and painful symptoms associated with poor gut motility, dysbiosis, and GI hypersensitivity. B. lactis is definitely one of the “good guys” of the gut bacteria world because it contributes to a healthy and balanced microbiome, which positively affects balanced blood sugar and optimal weight maintenance. Key Takeaways: "A particular strain of B. lactis, known as HN019, has been shown to have a significant impact on those with metabolic syndrome. This probiotic had beneficial effects on inflammation, nitric oxide metabolites, and antioxidant measurements, and the authors of the study stated that if their results are confirmed, supplementation with this probiotic should be considered further." Read more: https://www.mindbodygreen.com/articles/bifidobacterium-lactis-weight-loss-inflammation
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Date:
September 05, 2018 08:52 AM
Even though sodium is required for basic survival, over half of Americans consume too much of it, largely because it is so heavily used in processed foods. Too much sodium can cause a number of symptoms, including swelling from water retention, excessive thirst, brain fog, and hypertension. On the other hand, too little sodium (hyponatremia) is also dangerous to your health, especially To cardiac function. To keep your sodium within healthy limits, it’s important to really know what’s in your food, and avoid processed foods as much as possible. Key Takeaways: "It is no secret that most of us consume way more sodium than our bodies need." Read more: https://www.naturalnews.com/2018-08-13-why-you-need-sodium-and-how-much-is-necessary-too-much-or-too-little-causes-health-issues.html
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Date:
August 02, 2018 09:53 AM
More and more celebrities such as Lebron James are endorsing alkaline water in order to raise awareness as to how important it is to have a buffer to various acids within your system. Highly processed foods and other risky products can cause our pH to be out of balance, making it hard for our bodies to process important things such as potassium and calcium. Having alkaline water in your system will serve as the much-needed buffer in order to keep your vitamins and minerals in check. Key Takeaways: "Alkaline water has gained rapid popularity in recent years among everyone from health enthusiasts to professional athletes, whether they’re following an alkaline diet or just trying to get more out of their hydration." Read more: https://draxe.com/alkaline-water/
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Date:
August 01, 2018 05:53 PM
A recent study has revealed a new treatment for skin exposure to UVB rays. Hesperidin is a compound found in many common citrus fruits, like oranges, and has more health benefits besides helping with the impacts of UVB rays. According to the paper, hesperidin also has impacts on wrinkles, aging, and inflammation of the skin. All of these benefits were confirmed through initial testing on mice. Scientists are hopeful for the future of hesperidin in skincare and treatment. Key Takeaways: "Results showed that mice that were treated with hesperidin had improved length and depth of wrinkles, as well as inhibited the development of skin thickness and epidermal hypertrophy." Read more: https://www.naturalnews.com/2018-07-30-hesperidin-prevent-photoaging.html
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Date:
July 26, 2018 01:53 AM
CBD is being used by children and adults across the nation. Scientists have proven that it has an immaculate number of health benefits, even stopping seizures in children when nothing else worked. Now, pet owners are reaching for CBD to stop their dogs anxiety and hyperactivity at rates so high it is not easy to keep the product on the shelves. CBD is all-natural, has instant results and has proven itself worthy of use time and time again and pet owners are thrilled with the results Key Takeaways: "BarkShop became the first online retail retailer to sell CBD products to dogs in March." Read more: https://mashable.com/2018/07/23/barkshop-cbd-products-for-dogs/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5674)
Date:
July 07, 2018 09:54 AM
If you want to lower your chances of getting cardiovascular disease, exercise will go a long way toward helping you reach that admirable goal. In fact, an active exercise routine can lower hypertension and also other chemicals in your body that are responsible for many chronic conditions, like diabetes. However, for a small few, exercise won't significantly help them fight it so many are turning to fennel for its many benefits including its lowering of antihypertensive in people. Key Takeaways: "For this study, the researchers trained their eyes on the fennel or Nigella sativa (NS)." Read more: https://www.naturalnews.com/2018-07-05-eating-more-fennel-keeps-your-heart-healthy-especially-if-you-take-them-regularly.html
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Date:
May 31, 2018 09:16 AM
Probiotics are important not only for digestive health, but also a person's overall health as well. Benefits of probiotics include relief from symptoms of gastrointestinal problems, but can also extend to other parts of the body, such as helping the body better ingest vitamins and minerals. Maintaining a healthy diet can help make sure the body maintains the necessary probiotics; however, some foods are better for consuming probiotics than others. Foods such as yogurt and miso are some of the best sources of probiotics. As part of a healthy lifestyle, reduce stress, eat healthy, and use antibiotics only when necessary to keep the gut a healthy home for probiotics. Key Takeaways: "Research has shown that either single-strain or multi-strain probiotic or prebiotic supplements can reduce palpitations, constipation, irritable bowel syndrome, lactose intolerance and discomfort." Read more: http://www.ejinsight.com/20180525-probiotics-are-the-guts-best-friends/
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Date:
May 26, 2018 05:16 PM
Asparagus does more than just help promote digestive health. It also is known for containing something called rutin, which is a flavonoid that has the ability to help reduce the risk of blood clots. Studies with rats have also shown that consumption of asparagus over a ten week time span can result in more regulated blood pressure in those who are suffering from hypertensive symptoms. Asparagus also contains glutathione, which is known for boosting the human immune system. Key Takeaways: "Asparagus is a low-calorie vegetable rich in antioxidants, minerals and anti-inflammatory properties. Asparagus also contains rutin – a flavonoid that helps to treat haemorrhoids and prevent blood clots." Read more: http://www.longevitylive.com/anti-aging-beauty/anti-aging-health-studies/asparagus-superfood/
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Date:
May 23, 2018 09:16 AM
Marijuana is historically known for its mind-altering impact on those who consume it, but this is primarily due to the THC that is present within the strand at use. CBD is a component that is also in all marijuana strands, but it does not promote the same psychological effects that THC does. CBD oil can be extracted out on its own so that patients can consume it for medical benefits without any concern for psychological symptoms. CBD has shown to be especially effective in treating inflammatory diseases, as well as anxiety symptoms. Key Takeaways: "By one estimate, the CBD industry has doubled in size over the last two years, and is now worth $200 million. But with this popularity the hype may have gotten ahead of the science." Read more: http://news.wfsu.org/post/anxiety-relief-without-high-new-studies-cbd-cannabis-extract
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Date:
March 28, 2018 09:17 AM
While the hibiscus is known as a very ornamental bloom, gracing many gardens, it has an economic role to play as well, serving as a product of high significance in both the food and cosmetic industries. This dual nature of the plant arises from the fact that the hibiscus is both highly nutritious and also the source of a safe coloring agent that can be used even in foods.
The periodical, 'Food Science and Human WellnessWellness', explored the viability of hibiscus-generated food coloring for cupcakes and found the resulting product to be both cost-effective and 'clean, ' with the added benefit of adding necessary flavonoids into the human diet. These anthocyanins, aside from the nourishment they provide, appear to be linked with the easing of numerous health complaints, including, hypertension, inflammatory conditions, coughing and excess weight. Key Takeaways: "Extracts from hibiscus calyces could be used as a natural food coloring, which can provide health benefits at the same time, according to a study published in the journal Food Science and Human Wellness." Read more: https://www.naturalnews.com/2018-03-26-hibiscus-extracts-can-be-used-to-provide-natural-food-coloring-with-health-benefits.html
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Date:
January 17, 2018 03:59 PM
B complex vitamins can solve many skin problems and help make hair healthy and lustrous. B complex includes Niacin (B3), Pyridoxine (B6), Biotin (B7), Folic Acid (B9) and Cobalamin (B12). These vitamins have been found to decrease or prevent eczema, hyper-pigmentation, acne, skin cancer, premature aging, vitilago, and dandruff. Hair follicle size also increases due to B complex. All of the B complex vitamins are present in a healthy diet containing a variety of fruits and vegetables. Where diet is lacking, B complex supplements can be used and are taken by millions of people. There are many health benefits not related to hair and nails that B complex provides. Be sure to get B complex vitamins daily to look and feel your best. Key Takeaways: "Dull, hair fall, lifeless hair and receding hairlines are problems that plague not only older people but also the youth of today." Read more: http://www.natural-health-news.com/how-does-vitamins-b-complex-work-on-skin-and-hair/
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Date:
January 10, 2018 03:59 PM
Eye bags can be a worrying thing. While not necessarily a health risk, the can show that you are not sleeping enough. They are almost like bruises, with blood pooling under the skin and showing those dark circles. You can help these problems with a few easy tricks. The first involve being more healthy, by cutting back on smoking and alcohol. You can also place potatoes or cucumbers on those areas, acting almost like a ice pack, to help bring down any swelling. Key Takeaways: "Although under eye dark circles are not exactly a health hazard but they may impact one’s look and hence confidence negatively." Read more: http://www.business-standard.com/article/health/get-rid-of-eye-bags-and-dark-circles-naturally-118010800598_1.html
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Date:
October 22, 2017 01:14 PM
High blood sugar can be very dangerous. If it gets too high you can even end up in a coma. Rosemary extract is one natural solution. It is found to work well and is safer than some of the medications out there which can contain harmful ingredients. Many prefer to go the natural route. They prefer to use herbs to take care of their medical problems. Diabetes is a common cause for high blood sugar. Key Takeaways: "The researchers found that rosemary extract can affect crucial insulin target tissues in fat, muscle and the liver and directly cause anti-diabetic effects." Read more: https://www.naturalnews.com/2017-10-19-rosemary-extract-found-to-be-a-powerful-anti-hyperglycemic-solution-for-people-who-have-problems-with-high-blood-sugar.html
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Date:
October 20, 2017 10:14 AM
Autism is a hard thing to diagnose and treat. There are different forms of it. There are also different levels of severity. Cannabis is one way some treat it even though it is controversial. Most cannabis uses are. There is scientific evidence that this may work. It is at least looking into if you can get past the stigma, though it might not work for everyone. Some don't react to it just like any other medication. Key Takeaways: "Looking at the quality of the social interactions, we found that our autistic-like mice tended to dart away from a social interaction and huddle in the corner of their testing box." Read more: https://www.civilized.life/articles/cannabidiol-treatment-for-autism-scientific-support/
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Date:
October 15, 2017 01:14 PM
Science is figuring out how ADHD can be treated without a strong medication. The key is Omega-3s. This is good news since many parents don't want to put their children on these medications because they an alter a child's modd. They are very powerful. Omega-3s can be found in fish and other foods, though. They are natural and safe. There are also supplements which contain them. It will not be hard to get them into your child's diet. Key Takeaways: "From the seven clinical tests, they discovered that omega-3 fatty acids improved the clinical symptoms of ADHD, such as inattention and hyperactivity, according to reports made by the parents of the observed children." Read more: https://www.naturalnews.com/2017-10-09-treating-adhd-naturally-the-science-says-omega-3s-make-a-difference.html
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Date:
October 07, 2017 01:14 PM
Fizer is doing a lot to keep people healthy. A lot of time and money is spent on this. It is good to know a large company like that has your back because health, both mental and physical, is very important. Once it's gone you can't always get it back. Fizer understands this and they are making sure things go well for many people by creating different things they can use to combat their poor health. Key Takeaways: "Your gastrointestinal tract is the most important organ of your immune system, but many people spend too much time feeding their mouth, not their gut." Read more: http://bangordailynews.com/link/fiber-will-fight-the-white-walkers-threatening-your-health/
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Date:
October 01, 2017 12:14 PM
Breakfast is an important meal. It can jump start your metabolism so you will lose more weight. Your body can burn calories faster when your metabolism is fast. This gives you a great breakfast for helping to achieve this. It can be considered a super breakfast. It is a good choice if you want to be healthier or if you're considering a diet. It is not full of fat or sugar the way lots of popular breakfast foods are. Key Takeaways: "The fat that is accumulating in the body can be the main cause of several diseases."
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Date:
September 22, 2017 09:14 AM
Gut microbes and their role in physical as well as mental health has received a lot of attention in the past few years. Researchers are claiming that some day probiotic medicines can be taken to combat disease, both mental and physical. his is not just hype. Serious research is being done to learn how these microbes work on the human body with the hopes of creating probiotic like medications someday. Read here about these recent research advances. Key Takeaways: "The gut microbiome does indeed show huge potential, but the research is still in its infancy, and many of the big questions remain unanswered." Read more: https://www.theguardian.com/commentisfree/2017/sep/07/gut-microbes-panacea-brain-probiotic
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Date:
September 19, 2017 12:14 PM
Blood pressure can be lowered a lot in only one month. This can be done with magnesium, according to a new study. The recommended dose worked great on men that took it and they found themselves with lower blood pressure after some time. The flow of blood was boosted as well. People who suffer from, or at risk for high blood pressure can benefit a lot from magnesium and should take some magnesium supplements to help. Key Takeaways: "The results of the study showed that taking a 300 mg magnesium supplement every day for one month is enough to significantly lower hypertension and improve blood flow." Read more: http://www.naturalnews.com/2017-09-12-reduce-blood-pressure-in-one-month-with-magnesium.html
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Date:
August 28, 2017 04:14 PM
There are some natural ways to lower your blood pressure without relying on any drugs. If you are relying on drugs to treat your blood pressure issues, then it is important to understand that you do not need drugs. Many classes of hypertension drugs have some very severe side effects. Exercise and meditation are two ways that you can lower your blood pressure. Getting 30 minutes of exercise every day during the week is a great way to start. Key Takeaways: "Engaging in regular exercise, around 30 minutes most days of the week, is key to maintaining a healthy blood pressure, as well as improving your overall cardiovascular heal" Read more: https://medshadow.org/features/hypertension-blood-pressure-lower/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5191)
Date:
August 27, 2017 12:14 PM
You can say goodbye to gout and also high uric acid levels with one powerful home remedy. Uric acid is an acid that is produced by the body when food is broken down during the digestive process. To eliminate it, the cells dissolve it and carry it to the kidneys through the blood stream. The kidneys then expel it. The kidneys filter the blood and get rid of the residue through urine. When there is a build up of this acid, there is an imbalance in the tissue. Key Takeaways: "Both artichoke and lemon help to control inflammation due to their diuretic and purefying properties that lower high uric acid."
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Date:
August 25, 2017 04:14 PM
High blood pressure is not something to take lightly. It can lead to stroke and heart problems if it is prolonged. There is medicine you can take but there is also a dietary way to help lower it. This talks about four foods you can eat to help you get there. Changing your diet is often a good way to control your health since putting good things into your body will help you to get good out of it. Key Takeaways: "This study highlights the need for long-term follow-up of women with a history of hypertension during pregnancy to provide early management of risk factors for cardiovascular disease" Read more: http://www.ndtv.com/food/4-foods-to-keep-high-blood-pressure-in-check-and-prevent-heart-disease-risk-1739973
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Date:
August 25, 2017 09:14 AM
A recent study conducted at the University of Nottingham in England has shown that a single dose of Cannabidiol can effectively lower blood pressure for individuals that are suffering from high blood pressure. This is great news, considering Cannabidiol is a non-addictive, natural medication. It is also an amazing breakthrough because this means that it can treat many other cardiovascular disorders, not just hypertension. Cannabidiol is believed to be a neuroprotectant that can help prevent cardiovascular disease and stroke, in addition to lowering an elevated heart rate. Key Takeaways: "Nearly 75 million adults in the United States suffer from hypertension, or high blood pressure. That means around 32 percent of the population is at an increased risk for heart disease and stroke. It’s very promising that CBD has the possibility of reducing and preventing certain cardiovascular disorders." Read more: http://www.cannatech.news/2017/08/21/single-dose-cbd-shown-reduce-blood-pressure/
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Date:
August 21, 2017 09:14 AM
Many health problems, and especially cancer and heart disease are caused by an imbalance of insulin, due to poor diet. We eat far too much sugar and too many carbohydrates. This leads to insulin resistance, which, in turn, leads to heart disease, high triglycerides, high cholesterol, osteoporosis, and diabetes. It also raises blood pressure because when we are insulin resistant our bodies cannot store magnesium, which is needed to relax the walls of the blood vessels. Dr. Michael Cutler has written a book, "The Insulin Factor" which explains how to get your insulin back in balance, through diet. This will help us to live longer, healthier lives. Key Takeaways: "Centenarian studies show no health consistency at all except that all the centenarians have relatively low insulin (sugar) for their age and they all have low triglycerides for their age." Read more: https://personalliberty.com/insulin-and-disease/
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Date:
August 20, 2017 04:14 PM
Flaxseeds have multiple properties filled with many reasons they are an overall great choice in a healthy diet and can aid in weight lose. The soluble fibers in flaxseeds can help to curve your hunger strikes and when you eat less and as a result, you do not put on more weight. The present fatty acids lower the inflammation that can increase weight gain. It only takes a tablespoon a day to get proteins and antioxidants along with a rich and nutty flavor. Key Takeaways: "Enriched with fibre, Omega 3 fatty acids and anti-oxidants, flaxeeds increase your body's efficiency to lose weight." Read more: http://timesofindia.indiatimes.com/life-style/health-fitness/weight-loss/flax-seeds-for-weight-loss/articleshow/60114327.cms
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Date:
August 08, 2017 09:14 AM
Mushrooms are known to be a health providing food. They are also not as commonly eaten in American dishes as they should be. Lion's Mane is a mushroom that Americans and others might what to add to their diet. It has garnered quite a bit of attention as an all-round powerhouse of health in several Asian based research studies. Korean studies indicate it fights cancer, Malaysian research indicates it might help with gastric issues and in Japan Lion's Mane has been shown to help as an anti inflammatory agent. Key Takeaways: "One study published in the Journal of Agricultural and Food Chemistry lists the benefits by stating lion’s mane mushroom is antibiotic, anticarcinogenic, antidiabetic, anti-fatigue, antihypertensive, anti-hyperlipodemic, anti-senescence [anti-aging], cardioprotective, hepatoprotective, nephroprotective, and neuroprotective, and improves anxiety, cognitive function, and depression. (1)" Read more: https://draxe.com/lions-mane-mushroom/
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Date:
August 02, 2017 12:14 PM
There's a lot of talk about cranberry juice and the wonderful benefits that it offers to your health. But, is this just a bunch of Hype, or is cranberry juice really healthy for you? Perhaps consuming a cup of delicious, fresh cranberry juice now and again is beneficial to your health, but you won't know until you read this article and learn the truth about cranberry juice and the benefits if offers to your health. Key Takeaways: "Cranberry juice has properties that fight both cancer and other tumors."
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Date:
July 28, 2017 12:14 PM
Insulin has many more health benefits than you may know. Usually, it can be found in the ingredients section of any "high-fiber" packaged foods inside of health food stores. What insulin does for these foods is act as a prebiotic as well as a sweetener, which is why companies use it because it has double the benefits. It also increases the fiber content that so many of us consumers Long for. You would actually be surprised that insulin contained so many amazing benefits. Key Takeaways: "Inulin is one of those rare ingredients that also naturally occurs in certain foods and actually lives up to its health hype." Read more: https://mothernature.com/2017/07/the-prebiotic-fiber-that-can-help-you-lose-weight-detoxify/
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Date:
July 28, 2017 09:14 AM
There are many signs of a thyroid disorder that you should not ignore. Sadly, any people do ignore these signs, assuming they're no big deal or that it is just their mind playing tricks on them. The truth is, this is a real condition, and one that is very serious. A quick diagnosis can change things, however, so pay attention to even the most subtle of signs, like the little ones that you will find listed here. Key Takeaways: "Thyroid disorders can affect a wide range of bodily functions and cause an array of confusing and often misdiagnosed symptoms." Read more: https://www.nytimes.com/2017/07/24/well/live/the-subtle-signs-of-a-thyroid-disorder.html?partner=rss&emc=rss
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Date:
July 26, 2017 09:14 AM
Alkaline water is a very hyped health trend. This is a mineral rich and low acidic water that is said to give you energy. It helps to lower the PH levels in your body and even prevents aging and it prevents cancer as well. Alkaline water contains things like potassium and calcium. It is much less acidic than tap water is. By drinking alkaline water, you are lowering the levels of acidity in your body, which is a good thing. Key Takeaways: "You might have heard the buzz around alkaline water. The mineral-rich, low-acidic water is said to give you energy, balance the pH levels in the body and even slow down aging and prevent cancer." Read more: http://www.metro.us/body-and-mind/health/is-alkaline-water-healthy
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Date:
July 23, 2017 05:14 AM
High blood pressure can be dangerous. Hypertension is when it gets really high and that's a real concern for many. This gives examples of foods which can help fight it, though, so there's hope. High blood pressure can be caused by stress. Many people have it for this reason. It would e easy enough to add these foods to your diet even if you can't do much about your stressers. All you have to do is find recipes you like which contain the ingredients, but watch your salt intake since that is counterproductive. Key Takeaways: "For millions of people, blood pressure can reach dangerously high levels."
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Date:
July 01, 2017 09:14 AM
A new study has shown that broccoli may be able to slow and even reverse type-2 diabetes, which accounts for 90 to 95 percent of those diagnosed with diabetes. The pharmaceutical approach, a drug called metformin cannot be used on some people because of the risks of kidney damage. The side effects of this drug are not pleasant, and include abdominal discomfort, muscle pain, and cramping. Researchers have determined that sulforaphane, which occurs naturally in broccoli is able to lower over-expressed high glucose genes that cause diabetes. With this discovery, researchers are hoping to stop the problem early and treat prediabetic patients using broccoli, thus avoiding type-2 diabetes altogether. Key Takeaways: "It’s impressive how the cures for debilitating health problems — say, a vegetable inside your fridge — can be easy to find." Read more: http://www.naturalnews.com/2017-06-26-broccoli-sprouts-discovered-to-be-a-secret-weapon-against-diabetes.html
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Date:
June 06, 2017 12:14 PM
A staple of Ayruvedic medicine, practiced in India, besides being a flavoring agent and useful for coloring fabrics, Turmeric is a highly nourishing herb, specifically a rhizome, with antibacterial, antiviral, anti-inflammatory and anticarcinogenic properties, to name a few. Hormonal imbalance, obesity and hypertension are a few other areas that can benefit from Turmeric use. Easy to incorporate into the diet, even small amounts are beneficial. A traditional golden milk, make with coconut milk, is tasty and provides many nutrients. Turmeric is an inexpensive way to boost your health every day and even makes a beautiful addition to the garden, should you decide to grow it. Key Takeaways: "it has only been recently that people throughout the rest of world have discovered the many uses turmeric has for health and well being and as a tasty addition to culinary delights. This little root can help our bodies in miraculous ways and also healing our pets." Read more: http://uk.blastingnews.com/health/2017/06/turmeric-curcuminthe-healing-root-001741961.html
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Date:
May 21, 2017 06:44 PM
Roughage fever, otherwise called hypersensitive rhinitis or regular sensitivities, can disintegrate the personal satisfaction of patients in a few ways. The reactions may fluctuate among people and may incorporate restlessness or laziness, lessened profitability at work or school, passionate pain and even humiliation of having runny nose, and dry mouth. The review members were in the vicinity of 18 and 60 years of age, had occasional sensitivities, kept up their general eating routine and physical exercises amid the review. Read more: Can Probiotics Improve the Quality of Life of People with Hay Fever?
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