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Could quercetin be the answer to your allergies?
April 30, 2022 10:34 AM
Author: Darrell Miller
Subject: Could quercetin be the answer to your allergies?
It's that time of year again, when the sneezing and sniffling starts. Seasonal allergies can make life miserable for millions of people. But what if there was a natural way to lessen your symptoms? Quercetin, a flavonoid found in many plants, might be the answer.
What are seasonal allergies and what causes them?
Seasonal allergies, also known as allergic rhinitis, are a type of inflammation of the nose that occurs when the immune system overreacts to airborne particles such as pollen, dust, or mold spores. The most common symptoms include sneezing, runny nose, and itchy eyes. Seasonal allergies can occur at any time of year, but they are most common in spring and fall. There are a number of different factors that can contribute to seasonal allergies, including genetics, weather patterns, and air pollution. In addition, people who suffer from other conditions such as asthma or eczema are more likely to develop seasonal allergies. treatment for seasonal allergies typically involves avoiding triggers and managing symptoms with medication. In severe cases, allergy shots may be recommended. With proper management, people with seasonal allergies can enjoy symptom-free days.
What is quercetin and where can it be found?
Quercetin is a plant-based flavonoid that has been shown to have potent anti-inflammatory and antioxidant effects. It is found in many fruits and vegetables, including apples, onions, and berries. Quercetin supplements are also available. Studies have shown that quercetin can help to reduce the symptoms of allergies, such as hay fever and seasonal allergies. It does this by inhibiting the release of histamine, which is a chemical that triggers allergy symptoms. In addition, quercetin can help to reduce inflammation and swelling. For these reasons, it is often recommended as a natural treatment for allergies.
How does quercetin work to alleviate allergy symptoms?
Quercetin has a wide range of health benefits, including reducing inflammation and acting as an antioxidant. Quercetin also has the ability to block histamine, which is one of the main molecules involved in allergic reactions. When histamine is released, it causes the symptoms of allergies such as runny nose, watery eyes, and hives. By blocking histamine, quercetin can help to reduce these symptoms. In addition, quercetin can also help to reduce the production of inflammatory molecules such as cytokines. This helps to further reduce the symptoms of allergies and inflammation.
How much quercetin should you take to see results?
So, how much quercetin should you take to see results? Studies on quercetin supplementation have used dosages ranging from 500 mg to 1,000 mg per day to start and go up as needed. Generally, the higher doses are used to treat specific conditions, while the lower doses are more typically used for preventative purposes.
Are there any other natural remedies that can help with allergies?
There is no doubt that allergies can be a real nuisance, causing symptoms such as itchy eyes, sneezing, and skin rashes. While medications such as antihistamines are commonly used to manage these symptoms, there may be other natural remedies that can help as well. For instance, researchers have found that medicinal herbs such as nettle and astragalus may help to reduce inflammation associated with allergies. Additionally, changing your diet to include more antioxidant-rich foods may make you less prone to allergic reactions. Overall, while medications can be an important part of managing allergies, there are many other natural strategies that may be helpful as well. By incorporating a variety of these strategies into your treatment plan, you can hopefully minimize the impact of allergies on your life.
How can you reduce your exposure to allergens in your environment?
Allergens are substances that can trigger an allergic reaction in certain individuals. While different allergies manifest themselves in different ways, the main goal for anyone who is trying to reduce their exposure to allergens is to create a healthier environment for themselves and their loved ones. There are a number of tactics you can use to do this, starting with some simple steps that can be implemented at home. These include installing high-efficiency particulate air (HEPA) filters in your HVAC system, thoroughly cleaning surfaces and dusting regularly, and eliminating any indoor plants. Other steps involve avoiding exposures outside of the home, such as limiting time spent in dusty places like construction sites or opting to stay indoors on high-pollen days during allergy season. Overall, by making a few small changes to your lifestyle, you can greatly reduce your risk of exposure to allergens and take back control of your health.
Can allergy medication be safely taken while taking quercetin supplements?
Many people experience the unpleasant symptoms of allergies, such as a runny nose, coughing, or itchy eyes. Fortunately, there are many different medications that can help to relieve these symptoms and allow you to live a more comfortable life. However, for some people, allergy medication does not provide adequate relief. In this case, taking quercetin supplements may be an effective alternative. Additionally, some research has suggested that quercetin may actually enhance the effects of allergy medication. So is it safe to take allergy medication while taking quercetin supplements? The answer is yes, but quercetin can affect the way certain medications are absorbed by the body and should never be taken without consulting a medical professional. By doing so, you can safely reap the benefits of both treatments and enjoy a more comfortable life free from pesky allergies.
The quick answer
Allergy sufferers often have to contend with a host of different symptoms, from itchy eyes and a runny nose to sneezing fits and anxiety. While there are a variety of over-the-counter medications available to provide relief, many people are hesitant to take them on a regular basis due to concerns about side effects. Quercetin is a natural compound that has been shown to be effective in reducing allergy symptoms. It is generally considered safe to take quercetin along with other over-the-counter allergy medications. While there is always the potential for interactions between different substances, quercetin and most over-the-counter allergy medications are unlikely to cause any problems when taken together. As always, it is best to speak with a healthcare professional before starting any new medication regimen while consuming natural vitamin and herbal supplements.
Reduce Inflammation Through Diet: Foods to Eat and Avoid
April 30, 2022 10:02 AM
Author: Darrell Miller
Subject: Reduce Inflammation Through Diet: Foods to Eat and Avoid
Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that many people deal with on a daily basis. It can cause pain and discomfort in the body, and it can make everyday activities difficult to perform. Luckily, there are ways to reduce inflammation through diet. We will discuss the foods that you should eat and avoid if you want to reduce inflammation. We will also provide some helpful tips for getting started!
How can you reduce inflammation through diet?
There are many ways to reduce inflammation through diet, but perhaps the most important is cutting out processed foods and sugar. These foods contain inflammatory compounds known as advanced glycation end products (AGEs), which can aggravate existing inflammation or cause it to develop in the first place. In addition, studies have shown that eating a diet rich in vegetables and lean proteins can help to lower levels of inflammation throughout the body. Choosing whole grains, fruits, and healthy fats like olive oil is also a good way to support a body that is fighting against inflammation. In short, adopting a diet low in sugar and processed foods and high in fruits, vegetables, and lean protein can go a long way toward reducing inflammation both now and in the long term.
Supplements to take to reduce inflammation?
Inflammation is a natural and necessary part of our immune response, but if it becomes chronic or extreme, it can cause issues for our overall health. There are many different supplements that have been shown to be effective in reducing inflammation and promoting overall good health, including omega-3 fatty acids, Boswellia, pumpkin seeds, and turmeric. These nutrients work by interfering with the production of inflammatory hormones and enzymes, changing the chemical balance within our bodies and helping to reduce swelling and discomfort. Whether taken as a capsule or added to your diet through food sources like fish oil or ginger tea, these supplements can be an excellent way to boost your system's ability to fight inflammation. So if you're looking for ways to reduce inflammation and improve your overall well-being, consider adding these key nutrients to your daily routine.
The most effective anti-inflammatory supplements, Fish oil, Curcumin, and Boswellia!
While there are a number of different anti-inflammatory supplements on the market, some have proven to be more effective than others when it comes to reducing inflammation in the body. Perhaps the most commonly recommended supplement for this purpose is fish oil, which is rich in Omega-3 fatty acids, a type of polyunsaturated fat that has been shown to be especially effective in reducing inflammation. Another popular anti-inflammatory supplement is curcumin, which gives turmeric its signature yellow color and is thought to have antioxidant and anti-inflammatory properties. Additionally, another powerful anti-inflammatory agent is derived from the resin of Boswellia trees called Boswellia extract. All of these compounds have been shown to reduce inflammation in various scientific studies and can therefore be considered among the most effective anti- inflammatory supplements available today.
Tips for getting started on a anti-inflammatory diet?
When trying to get started on an anti-inflammatory diet, there are a few key strategies that can help make the process more successful. First, it is important to stock your pantry and fridge with plenty of healthy foods like fruits, vegetables, lean proteins, nuts, seeds, and reduce refined sugar intake as much as possible. These nutrient-dense foods are packed with essential vitamins and minerals that help to reduce inflammation and promote overall health.
Another key strategy to keep in mind when starting an anti-inflammatory diet is the use of supplements such as curcumin and CBD. These powerful compounds are believed to have anti-inflammatory effects in the body, helping to curb inflammation at its source vs. simply masking symptoms with painkillers or steroids. You can incorporate these supplements into your diet by taking them as pills or liquids or by incorporating them into your cooking through recipes like curried chicken or infused coconut oil tinctures.
The latest for calmness, relaxation, and to fight inflammation is CBD
CBD, or cannabidiol, has become increasingly popular in recent years as a natural solution for relieving stress, promoting relaxation, and managing inflammation in the body. Unlike THC, which is the psychoactive compound found in cannabis, CBD does not produce any high or altered state of consciousness. Instead, its many benefits are achieved through interactions with various receptors throughout the body, modulating mood and regulating pain response. As more and more people turn to CBD to achieve a sense of calm and well-being without depending on traditional pharmaceuticals, this powerful compound continues to gain widespread attention as a promising treatment option for everyday health issues. So if you're looking for a natural way to feel more mellow and at peace with yourself and your environment, consider giving CBD a try! With proven effects on everything from chronic pain management to improved sleep quality, this powerful all-natural remedy has something to offer everyone. Whether you're ready to give CBD a try for yourself or just curious about its many potential benefits, there's never been a better time than now to learn more about this exciting new approach to health and wellness.
Inflammation is one of the most common health concerns today, affecting people of all ages and backgrounds. While diet and lifestyle can be major contributing factors like white sugar, there are also a number of dietary supplements that can help to reduce inflammation in the body. Curcumin, fish oil, and CBD are some of the most popular supplements for managing inflammation. These substances work by targeting key pathways involved in inflammatory responses, helping to prevent or reduce swelling and pain. They can be taken on their own or combined with other anti-inflammatory compounds for maximum effectiveness. Ultimately, whether you are trying to manage chronic illness or simply boost your overall health, using supplements such as curcumin, fish oil, and cbd can be a great way to go about it. So if you're looking for more tools to manage inflammation in your diet, these are certainly worth trying out.
Whatever methods you choose, remember that making small changes over time will be much more effective than trying to overhaul your lifestyle all at once. With a little patience and persistence, you can start down the path toward better health today! Let dietary supplements assist you in your goal to reduce inflammation each day for a life time!
CBD oil reduces chronic illness pain
July 30, 2018 01:53 PM
Author: Darrell Miller
Subject: CBD oil reduces chronic illness pain
CBD oil reduces chronic illness pain
One of the compounds in marijuana is cannabidiol (CBD), whose interactions with the endocannabinoid system of the human body can produce a number of beneficial health effects, including helping with pain control. CBD is a safe, non-addictive, non-narcotic compound with few side effects that can reduce inflammation and pain in patients with fibromyalgia, intestinal complaints, multiple sclerosis and other conditions. We are just starting to understand CBD and the endocannabinoid system, and there is an urgent need for more research into this emerging field of medical knowledge.
- Human beings have an endocannabinoid system, which CBD oil interacts with when taken internally, thereby positively affecting pain levels.
- Considered an agonist, or promoter of the endocannabinoid system, CBD oil, is beneficial to those suffering from fibromyalgia.
- It's been shown that antagonists, that work against the human endocannabinoid system, exert a detrimental effect in fibromyalgia sufferers.
"CBD oil, in particular, is growing in popularity, for its ability to treat a number of ailments without the psychoactive effects typically associated with regular cannabis."
Read more: https://www.naturalnews.com/2018-06-21-cbd-oil-reduces-chronic-illness-pain.html
Cannabinoid-Pharmaceutical Interactions: What You Need to Know
February 17, 2018 03:59 PM
Author: Darrell Miller
Subject: Cannabinoid-Pharmaceutical Interactions: What You Need to Know
With the regulatory environment shifting seemingly by the day across much of the U.S., many consumers are getting their first opportunities to consider the benefits of cannabinoids as a means of treating what ails them. However, like any medicines, there are interactions with other pharmaceuticals that need to be taken into consideration. Specifically, they can inhibit the reception and mechanisms of action of many common prescription drugs, including common opiate painkillers. In order to check side effects, it's best to keep a close eye on the literature and carefully research any possible interactions.
- Cytochrome P450 is the key to metabolizing both these drugs and what interacts in our body with it.
- Cannabinoids may be the key to opiod addiction due to their poor ability for long term dependence and physical addiction
- You will need to monitor what you take since other drugs can interact poorly with cannabinoids.
"Cannabis has demonstrated efficacy in treating pain, and some phytocannabinoids have been suggested for various metabolic conditions."
Read more: https://www.projectcbd.org/about/cannabis-pharmacology/cannabinoid-pharmaceutical-interactions-what-you-need-know
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Treating Autism With Cannabis Now Has Scientific Support
October 20, 2017 10:14 AM
Author: Darrell Miller
Subject: Treating Autism With Cannabis Now Has Scientific Support
Autism is a hard thing to diagnose and treat. There are different forms of it. There are also different levels of severity. Cannabis is one way some treat it even though it is controversial. Most cannabis uses are. There is scientific evidence that this may work. It is at least looking into if you can get past the stigma, though it might not work for everyone. Some don't react to it just like any other medication.
- Autism is characterized by reduced activity in certain brain cells that make people hypersensitive to certain stimuli.
- CBD found in marijuana has proven to have benefits for people with neuropathic disabilites or chronic pain.
- Because marijuana is still classified as a Schedule I drug, there is still more work to do before it can be used readily medically.
"Looking at the quality of the social interactions, we found that our autistic-like mice tended to dart away from a social interaction and huddle in the corner of their testing box."
Read more: https://www.civilized.life/articles/cannabidiol-treatment-for-autism-scientific-support/
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Four good reasons to keep oil of oregano around at all times
July 20, 2017 12:14 PM
Author: Darrell Miller
Subject: Four good reasons to keep oil of oregano around at all times
Oregano is an herb. It is found in many Italian dishes. You can buy it fresh or dried. You can also get oil of oregano. This talks about that specifically. It gives reasons to keep that on hand. There are four good reasons which will make you want to go out and find this for yourself. You'll like using this natural product instead of having to take meds. Not everyone likes those because of their possible interactions with otehr meds and with the body in general.
- Oil of oregano has many uses besides being used for cooking.
- Besides helping with certain sicknesses oil of oregano can be used for other purposes.
- Oil of oregano is very useful, here is how to use it and how to make it.
"Do you carry a bottle of oregano oil with you? Maybe you should."
Read more: http://www.naturalnews.com/2017-07-18-reasons-keep-oil-of-oregano-around-at-all-times.html
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6 Health Benefits Of Maca
June 13, 2017 09:14 AM
Author: Darrell Miller
Subject: 6 Health Benefits Of Maca
Maca, a cruciferous plant similar to broccoli and cauliflower, could provide health benefits to those dealing with issues related to aging. The root of Maca is ground and dried to a powder. With it's slightly sweet taste, it can be added to numerous dishes and drinks as a supplement. Both men and women can benefit from the added nutrients,fats and acids, as little as a teaspoon a day can be effective. There are no noted side effects from adding Maca as a dietary supplement for healthy persons. Those taking hormones or other medications may need to consult a physician for any possible interactions.
- Like cauliflower, broccoli and cabbage, maca belongs to the family of cruciferous vegetables that is grown in the high mountains of South America, and most often in Peru.
- In South America, maca has been consumed and known for its many health benefits for thousands of years. Here, we are just starting to understand the great healing powers of this pleasant-tasting root.
- Maca has been proven to improve libido in both men and women, although don’t expect results overnight
"If you haven’t already tried it, the maca root (Lepidium meyenii) is one versatile superfood to start paying more attention to."
Read more: http://www.thealternativedaily.com/health-benefits-of-maca/
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Antioxidants- How To Fight With The Free Radicals
January 04, 2017 10:37 PM
Author: Darrell Miller
Subject: Antioxidants- How To Fight With The Free Radicals
Free radicals are of good concern to any individual who wants to stay healthy. You have possibly heard of how hazardous these substances are and how essential are antioxidants that battle them. Understanding free radicals involves mastering just a little bit about their chemical background. Your body is made up of numerous connected parts. The organs and tissues that form these parts are all made from cells. In original terms, each cell is an independent unit that processes its waste and ingests nutrients, additionally to performing several other functions.
How do cells perform? The answer varies depending on the distinct cell. Some produce the power utilized to move muscles, and others transport nervous impulses, but all are powered by chemical reactions. These reactions, or interactions among the electrons that surround every atom in the universe, also happen inside our bodies. Without the several various molecules or groups of atoms, that chemical reactions produce, we couldn't survive.
The Chemistry That Drives Our Cells
Chemical Reactions: All About ChargeChemical reactions typically result in bonds between specific molecules, developing compounds like vitamins, minerals along with other substances utilized to construct cells. Reactions take place due to the fact some molecules have positive and negative electrical charges because of the way their electrons are arranged. In most situations, chemical reactions keep occurring until these charges have already been balanced or canceled out completely.
Free Radicals: Unbalanced ProductsOccasionally, nonetheless, reactions produce free radicals. In chemical terms, radicals are unbalanced factors. These molecules retain charges for any number of causes, according to the reactions that formed them.
For a reason that charges are what attract atoms to each other, free radicals which have unbalanced charges are reactive. Free radicals are far more likely to bring about chemical changes than other balanced molecules, and these adjustments may be harmful or useful.
Even though some free radicals are necessary for biological functions or take place as intermediate stages of more complex reactions, others sit around with no use, waiting until they make contact with anything they can react with. As your body is a whole mass of atoms and chemical compounds, no cost radicals typically don't have to travel that far to locate something they can mess up.
Free Radicals All Around
An extremely common radical reaction You're possibly familiar with is rusting. Rust is built up as a result of charged oxygen atoms from water reacting with metals, generating corrosive byproducts which are often brown. Although these reactions are fairly a common occurrence in metal in vehicles or appliances, they may also be responsible for the browning you see in sliced apples left exposed to the air.
Rust reactions occur since the oxygen in moisture has a charge. Though water is a complete molecule, its unbalanced, or polarized, form means that it tends to react, coming apart easily to leave charged oxygen behind. This oxygen joins with the metal molecules inside your body just as simply as it does those in a piece of iron. When your body could not become a rusted hulk of an old ship, it undergoes internal alterations.
Can 5-HTP Help with Sleep?
May 26, 2014 12:57 PM
Author: Darrell Miller
Subject: Can 5-HTP Help with Sleep?
What is 5-HTP
5-HTP (5-Hydroxytryptophan) is a compound which is produced naturally in the body via the means of the amino acid tryptophan. Even though this compound is already present in the body, researchers have found that we can benefit by having more of it. This has resulted in several supplement companies producing this compound from the seeds of an African plant known as Griffonia simplicifolia; 5-HTP can now be found in many health food and drug stores.
Benefits of 5-HTP
Even though there still hasn't been much research done regarding this supplement, we can still see that there are many uses for it. However, there is sufficient evidence out that shows 5-HTP is effective in treating depression and fibromyalgia, which means improved mood, reduced pain, better joint health, and better quality of sleep. To elaborate on the sleep benefits, 5-HTP increases serotonin levels which are converted into melatonin (a hormone which helps keep sleep cycles under control) through the body. There is also some evidence to suggest that this supplement can reduce anxiety as well as help promote weight loss in obese people.
So there is some great evidence to suggest that this supplement can help to improve our mood, quality of sleep, health and much more. However there is a slight downside, because of the limited amount of research done on this compound it is currently considered possibly unsafe to use. Potential side effects of 5-HTP include muscle ache/pain, heartburn, nausea, vomiting, drowsiness, stomach pain, and also a serious condition known as eosinophilia myalgia syndrome – a rare flu-like condition. Drug interactions can take place also; you should stay away from 5-HTP especially if you are taking any anti-depressant medication as these often increase serotonin levels which may result in too much serotonin in the body.
This supplement has many benefits and there has been research done to prove that it is effective in treating many problems such as insomnia, depression, fibromyalgia, anxiety, weight loss and more. However, it is recommended that you stay away from supplementing with 5-HTP because of the limited research done.
What Is Monolaurin And What Are Its Health Benefits?
December 29, 2012 10:38 AM
Author: Darrell Miller
Subject: What Is Monolaurin And What Are Its Health Benefits?
Get An Immune Boost:
Man has made a big leap as far as science and pharmacology are concerned, but there are still a lot of substances useful to human health that are waiting to be discovered. There are also those substances naturally occurring but whose pharmacological properties have not yet been explored. Monolaurin, for instance, is a naturally occurring substance whose use in human health has only been lately discovered.
Monolaurin, also called glycerol monolaurate and glyceryl laurate, is a 12-carbon fatty acid as well as a monoglyceride. Although it is a derivative of coconut oil, it is most commonly prepared as a lauric acid mono-ester. Aside from coconut milk, it is also present in human breast milk, which is known to function as an immune protection passed on from mother to child after childbirth. The potency of breast milk as an immune barrier is evidenced by the stunted growth and frequency of infections seen in infants deprived of breast milk. But, all this is old information.
What's new about monolaurin?
Known Uses of Monolaurin:
Before we get to new information, it's important to look into the discovery of monolaurin. Way back in the 1960's, then University of Detroit professor Jon Kabara made an important discovery - that the combination of lauric acid and glycerol can be used in fighting germs. First marketed as a dietary supplement called Lauricidin, it was soon marketed by other pharmaceutical companies, but Lauricidin remains its most potent and purest form.
Since its discovery, it has been used as symptomatic treatment (and prevention) for the common colds, flu, herpes, and many other infections.
Working similarly to breast milk, it helps protect the immune system from infections and other ailments. Some Lauricidin users also claim that the substance is useful against Chronic Fatigue Syndrome and even autism. As for viruses, it has proven to be a useful supplement against HIV, Measles, Herpes Simplex, Epstein-Barr Virus, and Cytomegalovirus, to name a few.
Recent studies have shown its in vitro antibacterial and antimicrobial activity, at least as far as superficial skin infections are concerned. Carpo, Verallo-Rowell and Kabara (2007) demonstrated the effectiveness of monolaurin versus common antibiotics in battling both gram positive and gram negative infections such as Staphylococcus and Enterococcus. Older studies have explained Monolaurin's mechanism of action - it inserts itself into the cell membrane, disturbs the cell membrane integrity of Gram positive bacteria, and therefore blocks cell replication.
Aside from medicinal uses, it is also used for other purposes as well. It is a common ingredient in many deodorants, thanks to its antimicrobial activity; body odor, as you may know, is caused by the presence of certain bacteria. It is also present in other products such as shampoo, detergents, soap, and even in certain foods such as ice cream and margarine.
Side Effects and Drug Interactions
As far as side effects are concerned, there is still a lot to be known. Some users may experience the Herxheimer Reaction, a complicated term that indicates the presence of fatigue, body ache, irritability and fever that may worsen before the medication takes effect. Use during pregnancy and breast feeding is contraindicated, given that not enough is known about its potential effects during this period. Dosage ranges from 0.75 to 3 grams, 2 or 3 times a day, and is taken after meals.
November 12, 2012 01:52 PM
Author: Darrell Miller
Lycopene is a carotenoid that is responsible for the red color in melon, tomatoes, rosehip, guava and pink grapefruits. it is known to be highly antioxidant meaning that it is very effective in neutralizing free radicals which could damage the body cells. Since its discovery in 1964 by Alex R. Torres, it has been observed that this compound is easily absorbed in the body when processed into sauce, juice, ketchup and paste. When consumed in the body, this product is deposited in the lungs, skin, colon, prostrate glands and the liver. There are numerous health benefits that are associated with consuming lycopene.
Free radicals in the body pose a major health risk as they are likely to steel molecules from healthy cells thus causing damage. In fact, these radicals have been associated with the cause of majority of the cancer infections. It is a strong antioxidant and it is able to stop these free radicals from damaging healthy cells.
Research has found that people who take products that contain lycopene regularly have reduced chances of getting heart diseases. It has also been observed that this compound can be used in the treatment heart diseases, osteoporosis, infertility and type II diabetes.
It has been found to posses numerous anticancer benefits. The compound helps the body against DNA damage which usually happens during the development stages of cancer. One of the ways through which lycopene is able to achieve this purpose is by blocking the interactions of stromal cells and tumors cells.
When the interaction is interrupted, the tumor and stromal tissues are inhibited from growing and developing. It is an indisputable fact that lycopene is a very important component in our lives. It is for this reason that medical practitioners advice people to consume carotenoid foods especially the ones that contain lycopene.
What is the History and Health Benefits of Pycnogenol?
March 24, 2012 07:51 AM
Author: Darrell Miller
Subject: What is the History and Health Benefits of Pycnogenol?
What Are The Health Benefits Of Pycnogenol?
Pycnogenol is a name of a product which is prepared from a tree French Pine also known as French Maritime Pine. Pycnogenol is a trademark name sold as a nutritional supplement. This supplement is mainly used for asthma and a condition known as chronic venus insufficiency. It is a water extract of the bark of the French Pine found in the coastal south west of France. Pycnogenol contains unique flavonoid compounds in high concentration. These compounds at such high levels of concentration have proven to be useful and beneficial on inflammation, cancer, Alzheimer's disease, diabetes, erectile dysfunction, aging and healing of wounds.
History and Discovery of Pycnogenol:
Pycnogenol is a very powerful antioxidant made from a combination of natural antioxidants and phytonutrients. Since it is biologically made it is technically a bioflavonoid. A French scientist by the name Professor Masquelier gave the name Pycnogenol which is a scientific name for the oligomeric proanthocyanidins (OPCs) as well as other bioflavonoids. Pycnogenol is an extract from the French Maritime Pine and grape seed extract. Professor Masquelier along with a Swiss broker Horphag made attempts to commercialize Pycnogenol. Horphag without the consent of Masquelier registered the name Pycnogenol as a patent in the year 1990 which came under the ownership of Horphag in the United States. This caused severe legal disputes in the US. Horphag made huge profits from the intellectual property of Masquelier. This wonderful antioxidant was discovered by Jacques Cartier in 1953. In his books Cartier mentioned about the benefits of pine and how it cured and healed chronic diseases. Professor Masquelier discovered Cartier's book and recognized the benefits of these medicines which were rich in bioflavonoids.
Health Benefits of Pycnogenol:
Pycnogenol is a very powerful antioxidant which helps in regulating certain types of acids that gets absorbed in the human body through chemicals and free radicals. Antioxidants help in improving heart health and prevent cancer. Brain diseases like Alzheimer's can also be prevented with the use of Pycnogenol. It prevents the body from absorbing the toxic elements which are responsible for the development of brain diseases. It works as a good preventive tool. Pycnogenol also helps people who suffer from heart disease, which is a very common disease worldwide. It reduces swelling due to heart disease and helps in regulating the blood pressure. Pycnogenol also assists in reducing blood sugar levels in type ll diabetes, administered along with the anti-diabetes drugs.
The anti-inflammatory and anti-oxidant properties of Pycnogenol are beneficial in treating asthma. It also improved the tolerance to chemotherapy in cancer patients. Pycnogenol works well as an anti aging product along with Vitamin E, and reduces wrinkles.
Pycnogenol is available in the market in different supplement formulas containing about 20mg to 100mg of Pycnogenol. It is the most extensively researched product and has also passed a number of safety tests. Tests have proved that consuming Pycnogenol at higher dosage for longer periods is safe though there are a few minor side effects. These side effects are gastro intestinal discomfort, nausea, dizziness and headaches. If consumed with certain drugs it can cause major side effects due to drug interactions. Pycnogenol is a great antioxidant supplement which helps in protecting and healing the body from harmful chemicals. Before taking Pycnogenol daily as a supplement it is recommended to consult physicians who can advice on the ideal dosages.
What are the Health Benefits of Oligonol?
March 23, 2012 08:12 AM
Author: Darrell Miller
Subject: What are the Health Benefits of Oligonol?
Oligonol is one of the few existing products in the market that has helped so many people so when one is asked what are the health benefits of Oligonol it's guaranteed that they won't fall short of words to say. This health supplement has anti-oxidant and anti-aging properties that help you achieve the best possible state of wellbeing. The following are some of the health benefits that you can get from using this natural supplement;
Improves blood circulation:Oligonol helps in improving blood circulation because it contains anti-oxidant elements that help in enhancing blood flow to the vital organs of the body.
Helps boost immunity: this health supplement fights against infectious bacteria and its agents and this is because it contains the lychee fruit which is a good source of vitamin C.
Helps reduce fatigue: in the research to find out what are the health benefits of Oligonol it was found that it helps speed up the body's recovery from fatigue after a period of physical exercises.
High energy levels: Helps increase energy levels in the body due to the fact that it helps facilitate the body's metabolic processes which in turn improves digestion.
Protects the body against cardiovascular diseases: when medical practitioners did a research on what are the health benefits of Oligonol, they found out that it contains minerals that include copper and potassium. These two minerals come from the lychee fruit. Potassium helps control a body's blood pressure and heart rate and for this reason protecting it from against diseases like strokes. On the other hand, Copper is important for the production of red blood cells in the human body. These blood cells are used to deliver oxygen to the body organs, tissues and muscles and without them the body would fail to function.
Reduces calorie levels and visceral fat production: use of oligonol health supplements helps reduce heart diseases risk that are brought about by visceral fat. Oligonol also contains elements that are rich in dietary fiber content and this helps control excess body weight.
Boosts memory: when asked what are the health benefits of Oligonol persons who had previously used the health supplement said it helped them remember stuff more easily than they did before they started using it.
Reduces stress levels: use of oligonol has proven to reduce peoples stress levels and it has been used as a remedy for depression as an added point to the research on what are the health benefits of Oligonol.
Inhibits production of influenza virus: previous studies gave sufficient proof that oligonol inhibits the production of the influenza virus by blocking the attachment of the virus to the body cells.
Improves skin: oligonol helps improve the skin appearance by reducing wrinkles and helping get rid of freckles on people's faces.
In addition, the oligonol health supplement is safe. This is because it is made from pure natural ingredients, and has no negative interactions therefore it can be used by all who would like to find out what are the health benefits of Oligonol and in turn benefit from it.
What Are The Different Types Of Ginseng And What Is Ginseng Good For?
December 16, 2011 06:44 AM
Author: Darrell Miller
Subject: What Are The Different Types Of Ginseng And What Is Ginseng Good For?
Ginseng is a considered to be a perennial plant which is a member of the Panax genus under the family of Araliaceae. It is abundantly found in North America, East Asia and other places which have a cool climate. There are many types of ginseng. Though different in kind, all these species of ginseng contains the active ingredient known as ginsenosides. This chemical substance is the one responsible for the many health benefits of ginseng.
The types of Ginseng are:
1. PANAX GINSENG. This type of ginseng is also known as Asian ginseng. It is very rich in ginsenosides which proves that it is included among the types of true ginseng.
2. PANAX QUINQUEFOLIUS. This ginseng has an effective adaptogenic property. It is otherwise known as American ginseng. This herb is also considered as a true ginseng.
3. ELEUTHEROCOCCUS SENTICOSUS. The other name for this herb is Siberian ginseng. However, it is not considered as a true ginseng because it does not contain ginsenosides but eleutherosides. Also, ginseng has a fleshy root while this herb has a woody one. Despite their differences, Siberian ginseng also has similar effects to true ginseng herbs. It has an adaptogenic property which can effectively improve the overall health of the individual.
As mentioned above, ginseng has many benefits to human health. These include:
1. IMMUNE SYSTEM BOOSTER. Ginseng contains several vitamins and minerals which can be helpful in improving the immune system as well as the overall health of the individual. Studies have shown that ginseng has an ample amount of Vitamin C which can help maintain the health and strength of the body’s immune system. As a result, ginseng can effectively improve health especially those who are one the recovery phase of an illness.
2. LOWERS BLOOD GLUCOSE. Asian ginseng is noted for its potential ability to help regulate blood sugar levels. This is made possible because of its action in the stomach and intestine to control the absorption of glucose from the diet. In this connection, health experts highly recommend that individuals under diabetic therapy must use ginseng with extra care because it might cause hypoglycemia or low level of sugar in the blood.
3. AFFECTS BLOOD PRESSURE. Ginseng can produce an effect to the blood pressure of the individual, either high or low blood pressure. Depending on the dosage and the person’s response, ginseng can effectively maintain blood pressure within it normal limits.
4. IMPROVES THE OVERALL STATE OF HEALTH. Many ginseng consumers have reported that they experience an increased sense of well – being with their regular use of such helpful herb. It is also commonly used for the improvement of one’s stamina and endurance in performing many mental and physical tasks.
Ginseng can be consumed raw. Others use dried roots of this herb. Supplements are also available in the form of tablets, extracts and teas. Ointments and creams are also formulated for topical administration. If you plan to use ginseng for a particular health indication, make sure to talk to your doctor first since ginseng can have significant effect to the body as mentioned above. This will greatly prevent adverse effects and interactions with other medications you are taking.
Can Apple Cider Vinegar Help With Cholesterol And Triglycerides?
December 05, 2011 09:40 PM
Author: Darrell Miller
Subject: Can Apple Cider Vinegar Help With Cholesterol And Triglycerides?
Apple Cider Vinegar And Cholesterol Apple cider vinegar is a classification of vinegar which is derived from apple or cider. As you can observe, apple has an acidic taste which makes it possible to be processed into a type of vinegar. Apple cider vinegar is pale yellow to amber in color. This kind of vinegar may be pasteurized or unpasteurized. Non - processed or unpasteurized form of apple cider vinegar has a semi - solid or firm appearance because of its thickness and cobweb - like make - up. This form of apple cider vinegar is considered to be the “mother of vinegar”.
Apple cider vinegar is yielded by mashing the fruit and squeezing out the juice it contains. Friendly microorganisms such as bacteria and yeasts are usually combined into the extracted juice to allow alcoholic fermentation. These microorganisms are the ones responsible for converting the sugar contained in the apple extracted juice into its alcohol form. Apple cider vinegar undergoes a second fermentation process. The alcohol produced from the first fermentation process is converted into its vinegar form by adding an ample amount of acetic acid – forming bacteria specifically known as Acetobacter. As a result, the juice extract will have a sour taste because of the acetic acid and malic acid it contains after several fermentations.
In the food industry, apple cider vinegar is commonly used as an ingredient of salads, marinades, food preservatives and the like. Aside from its acetic acid content, apple cider vinegar also contains amino acids, vitamins and minerals.
Clinical studies on whether apple cider vinegar can help control the amount of bad cholesterol and triglycerides in the blood have shown significant results. Yes, apple cider vinegar can have promising effects on the regulation of serum cholesterol and triglycerides. However, the studies also revealed that this fruit extract must not serve as a substitute for the medications prescribed by your doctor to regulate blood cholesterol and maintain or improve cardiovascular health. In animal studies, apple cider vinegar has shown positive effects on lowering triglycerides by almost 50 %. However, effects on Low Density Lipoprotein or the so – called “bad cholesterol” are not that efficient.
Needless to say, the American Heart Association stated that a good lifestyle and balanced diet can effectively reduce the amount of bad cholesterol and triglycerides in the blood. Apple cider vinegar will also greatly help in lowering these substances in the blood.
Other studies have also revealed that the acetic acid content in apple cider vinegar stimulates the expression of the genetic material which activates fatty acid oxidation enzymes. As a result of this biological process, there will be a significant lowering or control of body fat accumulation by the liver. This is the reason why apple cider vinegar can also be employed as a weight loss agent.
Apple cider vinegar is all – natural. Therefore, safety is relatively established. However, health experts still suggest that before you start using this product, you have to consult your doctor and discuss your current and past health condition as well as the other medications you are taking. This will reduce the incidence of adverse health reactions and drug to drug interactions.
What Makes Vectomega The Better Fish Oil Choice?
October 20, 2011 01:44 PM
Author: Darrell Miller
Subject: What Makes Vectomega The Better Fish Oil Choice?
Fish Oil Whats Best? The body requires various nutrients to be able to maintain health and prevent diseases. One of the most important nutrients that are essential to the body is the Omega-3 fatty acid. Omega-3 fatty acids include Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). These essential fatty acids (EFA) cannot be produced by the body but can be derived from fish oils. Fatty acids are important in the growth and development of the central nervous system. It is also useful in the prevention of certain cardiovascular diseases because of its cholesterol - lowering property. One of the most popular essential fatty acid supplements is the product called Vectomega. This supplement is a natural Omega-3 fatty acid complex which consists of DHA, EPA, essential phospholipids and amino acids.
Vectomega is an excellent supplement for individuals who do not acquire Omega-3 fatty acids in their daily regular meals. Some of its advantages are:
1. ALL NATURAL. This fatty acid supplement is completely all – natural. In addition, clinical studies revealed that it has the most level of natural oils in the commercial world of essential fatty acid supplements. This product has undergone a process which is patented and is free of synthetic chemicals. The process only utilizes natural enzymes and cold water as solvent.
2. INCREASED ABSORPTION RATE. Chemically, Vectomega has been found to be 50 times more absorbable than any other essential fatty acid supplements.
3. NO FISHY TASTE AND SMELL. Another advantage of this supplement is that though it is extracted from fish oils, it has no fishy aftertaste and won’t give you a breath smelling like you have just eaten fish for meal.
4. NO REFLUX. Unlike the other kind of fatty acid supplements, it cannot produce a disturbing gastric reflux after taking.
5. MORE SOLUBLE AND BIOAVAILABLE. It is also more soluble and is considered to be the most bio-available among the other fish oil supplements. It has been graded high in terms of active bioavailability among Omega -3 fatty acids under phospholipid reaction.
6. MORE PRACTICAL. It is a practical choice. One renowned pharmaceutical association stated that 2 tablets of Vectomega are equivalent to 12 to 16 capsules of another fish oil supplement.
7. ANTIOXIDANT. Not to mention, it is effective not only as essential fatty acid supplement but also an anti – aging agent because of its potent antioxidant property.
Vectomega have undergone many thorough clinical studies. It has been claimed to be safe and effective to supply the body with sufficient amount of essential fatty acids. However, health experts still suggest that it would be best and most safe to seek medical consultation first before starting supplementation. This would significantly prevent any untoward effects and abnormal interactions with other medications and supplements you are taking. The recommended dosage of this supplement is 2 tablets everyday for 30 days and then only one tablet daily for the next months and so on. However, if you wish, it is still safe to continue with 2 tablets per day for a more improved benefit.
What Are The Cruciferous Vegetables With Indoles?
October 18, 2011 02:19 PM
Author: Darrell Miller
Subject: What Are The Cruciferous Vegetables With Indoles?
A cruciferous vegetable is a common category of vegetables. The term cruciferous is used to refer to vegetables which have a cross - shaped pattern that can be found under the core of the plant's stalk. This classification of vegetables includes:
1. CABBAGE. This vegetable is a common leafy green vegetable of the specie Brassica oleracea. It is an herb - like, biennial flowering plant which has a short stem with a jam - packed mass of leaves. The leaves are generally green to light green but variety comes in red or purple color. An immature cabbage has a characteristic compact and circular cluster of young leaves.
2. BROCCOLI. A kind of vegetable which is categorized in the Italica cultivar plant cluster. This is different from cabbage because it has large flower heads which is usually dark green in color. It is arranged in a small tree – like manner on branches which is sprouting from a solid edible stalk. This vegetable is similar to cauliflower, another cruciferous vegetable.
3. CAULIFLOWER. Like cabbage and broccoli, cauliflower is also a member of the species Brassica oleracea. Unlike cabbage, this cruciferous vegetable is an annual plant which is reproduced by seeds. The appearance of this plant is like that of a broccoli. The floral meristems are usually eaten only while the stalk and leaves are utilized in vegetable broths.
4. BRUSSEL SPROUTS. This is a cultivar of cabbage family which is cultivated because of it edible buds. It is named after the city in Belgium which is believed to be the origin of the vegetable.
Cruciferous has many health benefits. Aside from its fiber – rich content, cruciferous vegetables has a promising benefit of lowering the risk of cancers specifically with that of the colon, breast and prostate. The special chemical compound in cruciferous vegetables is called “Indoles”. Indoles are considered as a phytonutrient which can benefit the body in many ways.
Since the ancient times, Indoles have been used for many medicinal purposes. In fact, most Roman health practitioners during the olden times have utilized Indoles as treatment for ulcerated breasts. Therefore, without a surprise Indoles found in cruciferous vegetables are widely used for the prevention of breast cancer. Clinical studies have revealed that the mechanism of action of Indoles in relation with decreased risk of cancer is that Indoles can effectively decrease the so – called C16 estrogen and increase C2 estrogen. The latter is helpful in preventing the development of abnormal breast tissue growth or cancer.
Furthermore, Indoles have also been found out to have important benefit in detoxifying the body from free radicals, thus preventing the body from free radical damage and promoting a healthy cellular production and growth. Other theories have stated that Indoles in cruciferous vegetables can block carcinogenic chemical compounds from mutating the cell’s DNA and neutralize the effects of estrogen associated with cancer development.
Other vegetables which contain Indoles are onions and garlic. The Indoles component of these vegetables effectively works hand in hand with antioxidants in protecting the body from harmful substances and toxins.
Aside from these natural vegetables, Indoles chemical compound can also be made available to the body in the form cruciferous vegetable extracts. This supplement has adequate amount of balanced Indoles compound which can equate with the body’s daily recommended intake of Indoles necessary to fight against free radical damage and cancer. However, extra caution must be observed to prevent untoward side effects and unnecessary drug interactions.
Cut the calories, try Indoles in supplement form!
Can Saw Palmetto Out Perform Synthetic Treatments For Enlarge Prostate?
October 03, 2011 02:53 PM
Author: Darrell Miller
Subject: Can Saw Palmetto Out Perform Synthetic Treatments For Enlarge Prostate?
Saw palmetto is a tree type of plant which is scientifically known as Serenoa repens. It is abundantly found along the coast of southeastern part of USA. This plant bears flowers which comes in yellow and produces fruits which are berry - like and reddish black in color. Saw palmetto supplements are extracted from the plant’s berries. The berries are rich in fatty acids and phytosterols. Saw Palmetto berry extracts are made by drying the berry and mixing it with a solvent like hexane and ethanol.
Since the ancient times, Saw Palmetto has been long used as an edible food and an herbal plant. The most common use of this herb is for the improvement of benign prostatic hyperplasia or BPH. This illness usually results to problems with urination and sexual activity. The enlarged prostate may obstruct the flow of urine making urination difficult and even painful for some. It can also affect the individual’s sexual activity because the prostate is the gland responsible for producing seminal fluid which is a component of the male ejaculate.
The mechanism of action of this herb in improving the condition of benign prostatic hyperplasia is that it inhibits the action of the enzyme called 5 – alpha – reductase which is involved in the abnormal growth of the prostate gland. Another theory on its action in relation to benign prostatic hyperplasia is that it can effectively interfere with the chemical substance called dihydrytestosterone. One of the reasons of prostate enlargement is that there is increased amount of the hormone testosterone that binds to androgen receptor sites. Saw Palmetto extracts have been found to bind with androgen receptor sites and act as a phytoestrogen. Therefore, if the receptor sites are already filled up, testosterone hormones will not be able to attach to these receptor sites and provide an effect to the body. Hence, if testosterone is minimized, enlargement of the prostate gland will also be controlled.
Benign prostatic hyperplasia is a serious health condition. Several prescribed medications are available to treat this illness. Indeed, saw palmetto extracts may be helpful but this supplement must not be used as a substitute for your prescribed medications. It may have similar actions with BPH drugs such as Finasteride but its potency is different. Clinical studies have also revealed that saw palmetto supplements do not directly decrease the size of the prostate gland but the lining inside the gland. It thins the inside layer of the gland thus minimizing pressure that rests on the urine tubes or urethra.
Saw palmetto is generally safe. However, since it can cause significant changes inside the body, it is important that you should talk to your doctor first before using this supplement, most especially when you already have BPH. You have to consult your doctor and discuss with him or her about your current health status, past medical history, familial health history and other medications taken whether prescribed or not. Dosage of the supplement is also best determined by your doctor. This will greatly help in the avoidance of untoward effects and unnecessary negative interactions with the other drugs you are taking.
Can Alpha GPC Really Help With Memory And Growth ?
September 29, 2011 11:52 AM
Author: Darrell Miller
Subject: Can Alpha GPC Really Help With Memory And Growth ?
What Are The Benefits Of Alpha GPC?
L-Alpha Glycerylphosphorylcholine, or abbreviated as Alpha GPC, is a natural compound which is choline in nature. It is considered to be an acetylcholine precursor which is now being studied as a treatment for the degenerative disease called Alzheimer’s disease. This chemical compound also has a parasympathomimetic property and is widely used as a nutritional supplement for enhancing memory and concentration. The other name of Alpha GPC is Choline Alfoscerate. Alpha GPC has the capacity to rapidly transport choline to the central nervous system by passing through the blood - brain barrier. Alpha GPC can be extracted from highly distilled soy phospholipids such as lecithin. Inside the body, this chemical compound can be found in high quantity in neuronal membranes. Some of its benefits are:
1. IMPROVES ACETYLCHOLINE LEVEL. As mentioned earlier, Alpha GPC can cross the blood – brain barrier. Once inside the brain, it positively influences brain activity by enhancing the production of acetylcholine. Acetylcholine is a neurotransmitter which is responsible for improving the individual’s learning process. Acetylcholine acts on both the peripheral and central nervous system. In the former, this neurotransmitter functions as the main neurotransmitter in the autonomic nervous system. It is also involved in the contraction of body muscles. In the latter, acetylcholine acts as an anti – excitatory chemical in the cholinergic system.
2. MEMBRANE COMPONENT. Another health benefit of Alpha GPC is that it can effectively protect nerve cells thus improving the transmission of impulse. Aside from maintaining the integrity of the nerves and nerve cells, Alpha GPC also serves as a precursor of the phospholipids found on membranes.
3. INCREASE HUMAN GROWTH HORMONE. Studies on Alpha GPC have revealed that it can relatively influence the action of the body’s Growth Hormone – Releasing Hormone (GHrH), thus improving the release of growth hormones. In addition, it can also enhance the effects of human growth hormone especially among young individuals.
4. A MODALITY FOR DEMENTIA. Alpha GPC has been long studied for the treatment of senile dementia. Initial result of such studies revealed that patients supplemented with Alpha GPC showed improvement but on a smaller extent. Further studies are still being conducted so that efficacy and safety as well as the appropriate dosage will be determined.
5. INFLUENCES GABA. Studies reveal that Alpha GPC significantly increase the synthesis and release of Gamma Amino – Butyric Acid or GABA. Increased synthesis of GABA is also potentiated by atropine. GABA is considered as the principal inhibitory brain chemical among mammals. It has a significant role in controlling neuronal excitation all over the nervous system. Like acetylcholine, GABA is also one of the primary responsible chemicals for the control of muscle tone.
Alpha GPC is formulated as supplement. It is available in 300 to 1,200 milligram oral supplements. Though it is generally safe, it is important that you should consult your doctor first before using this supplement. This would significantly avoid the occurrence of adverse effects and drug interactions. Appropriate dosage will also be determined by your doctor. Remember, any medication or supplement varies from person to person on its therapeutic and adverse effects.
Can I Use Senna Leaves As A Laxative Daily?
September 27, 2011 12:52 PM
Author: Darrell Miller
Subject: Can I Use Senna Leaves As A Laxative Daily?
What Are Senna Leaves Good For?
Senna is a plant which belongs to the family of flowering plants known as Fabaceae. This plant can be abundantly found in tropical regions. This plant is considered to be a shrub. However, some seemingly looks like an herb or a small tree. Senna is one of the most commonly used herbal laxatives. Other names of Senna are Cassia Senna, Tinnevelly Senna, India Senna, Alexandrian Senna, and Khartoum Senna.
The active ingredients of Senna are called Anthraquinone and glycosides. As a laxative, the active chemical in Senna acts primarily on the large intestine, therefore, this herb has a promising effect in relieving constipation. Clinical studies have also reported that Senna can enhance peristaltic movement of the intestines. This is possible because of its irritating effect on the mucosal lining of the intestines.
To be specific, Senna is an effective laxative. It is categorized as a bowel stimulant or irritant. This type of laxative acts primarily on the mucosa of the intestines and stimulates the nerve plexus to influence water and nutrient absorption as well as reabsorption. This alteration will then lead to the stimulation of peristaltic activity of the bowel. Thus, digestive tract movement is increased and stool elimination is induced. However, this may not be safe under certain circumstances. For this reason, stimulant laxatives must be used cautiously and employed for a short period of time only. As a result, Senna can also be employed as one of the weight loss herbal agents.
Moreover, the leaf of Senna plant consists of essential oils which can potentially destroy harmful microorganisms that can cause skin irritations such as rashes, blisters and acne. In the traditional medicine, Senna leaves are prepared in the form of paste which is then applied on skin to treat ringworms and other skin infections.
In addition, another health benefit of Senna is its potent antioxidant property. According to chemical studies, Senna herb contains high amount of antioxidants. Antioxidants are important to the body because they help prevent diseases by way of eliminating harmful toxins from the body. One of these harmful chemicals is called free radicals. These kinds of substances occur naturally in the body as an end – product of biological reactions. Free radicals can cause interruption on cellular division by altering replication of DNA. Aside from that, it can also cause damage to healthy cells of the body, thus promoting illnesses and diseases.
With the several health benefits of Senna, it must not be employed as a substitute to prescribed medications. This herb is available in supplements. You can purchase this product in many health and drug stores or even Online. However, it must not be abused. More importantly, medical consultation must be done first so that adverse effects and untoward drug interactions will be avoided. Use Senna herbal supplement as labeled or prescribed. Like any other laxative, do not use this in large amount and for a longer period of time. This may cause dependence in which you cannot have a bowel movement without the use of such supplement or laxative.
How Does Boswellia Fight Inflammation?
April 13, 2011 03:57 PM
Author: Darrell Miller
Subject: How Does Boswellia Fight Inflammation?
Boswellia refers to the species of trees where the aromatic gum resin frankincense is obtained from. In herbal medicine, the term Boswellia often means Indian frankincense, which is noted for its potent anti-inflammatory properties. It has a centuries-old association with Ayurvedic medicine, and herbal preparations containing its extracts are formulated for arthritis. It now comes in supplements marketed as a viable treatment for inflammation-induced illnesses, such as arthritis, colitis, and asthma.
Indian frankincense, also known as dhoop in India, is entirely derived from Boswellia serrata, and the common frankincense from a completely different species. The earliest known study looking into its purported benefit as an anti-inflammatory medication was in 1998, and it investigated its effects on asthma. In a span of 6 weeks, the boswellia group took 300 mg of the preparation three times a day and 70 percent experienced a significant improvement in symptoms and a noticeable decrease in incidence of asthma attacks in comparison with the control group.
In Ayurvedic medicine, boswellia has been utilized for hundreds of years with an emphasis on its use in the amelioration of joint pains. It is generally considered safe, explaining its prevalence in the treatment of arthritis and related disorders. Boswellia was the subject of several studies devoted to better management of osteoarthritis, and these studies published results that attracted more research. Today it is also touted to be useful for rheumatoid arthritis, which is inflammatory in nature.
Recent studies yielded outcomes in favor of its anti-inflammatory claims. In 2007 one study pointed to its medicinal potential in the treatment of colitis, concluding that patients with chronic inflammation of the colon went into remission after regular intake of boswellia. In a similar study, individuals diagnosed with inflammatory bowel disease reported to have benefited from 6 weeks of supplementation while those who sought conventional treatments responded to their medications in a much longer time.
Boswellia remains under scrutiny. Anecdotal evidence has been very positive largely owing to the fact that it hasn’t been linked to any adverse effect at all. But how does it work? There are many chemical reactions which boswellia may be directly involved in. It has been observed that it reduces the synthesis of pro-inflammatory leukotrienes. These mediators of inflammation are produced in the presence of an enzyme called 5-lipoxygenase, which is thought to be counteracted by the high terpene content of boswellia.
Triterpenes in boswellic acid, the active ingredient unique to boswellia, are also believed to interfere with the adhesive interactions between leukocytes and endothelial cells present in the gastrointestinal tract. Leukocyte elastase is a serine protease, a special kind of enzyme, released by leukocytes or neutrophils during inflammation. It is postulated that boswellia down-regulates leukocytes and leukocyte elastase in addition to inhibiting the expression of endothelial cells adhesion molecules. Down-regulation of leukocytes will help reduce inflammation and improve health.
If you are fighting systemic or joint inflammation, give boswellia a try and feel the difference!
Can Butterbur Help Me with Migraines
April 02, 2011 12:14 PM
Author: Darrell Miller
Subject: Can Butterbur Help Me with Migraines
Butterbur and Headaches
Butterbur has helped countless of migraine sufferers for more than three decades. In Europe, it is available as a prescription drug, which neurologists have prescribed since 1972. It has been the subject of numerous studies and reviews in a span of 40 years that have come to a conclusion that it does alleviate symptoms of migraine and reduce frequency of attacks. It is one of the herbal remedies clinically tested in migraine centers in the US. To date there has been no recorded adverse effects and harmful drug interactions, and as such available in the US over the counter, no prescription required. It has been compared to beta blockers and anticonvulsants and in general believed to be better than both of these more common treatments.
Petasites hybridus, the common butterbur, is the herb where butterbur extracts are obtained from although other species that belong to the genus Petasites are also known to produce the same health benefits. Petasites comprises up to 20 plant species widely distributed across the globe, a number of which have been tied to folk medicine throughout the ages. Petasites hybridus is native to North America and thrive well in marshes and wetlands, where there is a significant amount of moisture in the soil.
American Indians have long used its rhizomatous roots to fight off headaches and inflammation-induced diseases, such as asthma attacks and hay fever. Indeed the discovery of the organic compounds petasin, isopetasin, and oxopetasin explained its long-standing association with the treatment of migraines and allergies. Today most butterbur preparations do not contain pyrrolizidine alkaloids, which were identified to cause liver damage. That being said, it is still best to seek professional advice and ask assistance in choosing products from a reputable laboratory.
Interferes with Releases of Pain Chemicals
The phytochemicals unique to Butterbur have been well investigated, and results point to their effects on inhibiting the productions of local pain chemicals, which are pro-inflammatory in nature. Leukotrienes are lipid mediators that supervise the productions of other intermediaries of inflammation. Prostaglandins are responsible for vasodilation of blood vessels and their consequent sensitization to pain. Butterbur has been observed to influence these two pain chemicals.
Plays the Role of a Natural Beta Blocker
Beta-adrenergic antagonists, or simply beta blockers, are a class of drugs that target endogenous catecholamines implicated in migraine attacks. Epinephrine and norepinephrine are catecholamines that act on beta-andrenergic receptors, leading to a reduced blood flow in the brain. This results in the spasmodic contractions of cerebral blood vessels characteristic of migraines. Butterbur works on the principle of blocking the effects of catecholamines and inducing normal blood flow to the brain.
Produces No Known Serious Side Effects
Most analgesics and beta blockers have been associated with several adverse effects, which more often than not include nausea, dizziness, and muscle weakness. Many have been reported to cause weight gain. None of these have been linked to regular use of butterbur, one of the reasons why it has enjoyed a surge in popularity in recent years.
If you suffer from Migraine headaches, give butterbur a try!
Why is It so Important to Give Your Child a Multiple Vitamin Mineral Supplement
March 11, 2011 11:42 AM
Author: Darrell Miller
Subject: Why is It so Important to Give Your Child a Multiple Vitamin Mineral Supplement
Giving a multiple vitamin and mineral supplement to your child is tantamount to protecting him or her from the unknown dangers of malnutrition. It is a fact that children are picky eaters. Besides, not all food that you put on the table provides all the nutrients that they need. Experts remain divided over the need to give children daily multivitamins, but it is a common belief that doing so is just the prudent choice to make as parents. Does it make any difference? Yes, it does. Research has pointed to the positive effects of vitamin supplementation, and it has been cited a lot of times that the bioavailability of these supplements is not bad at all. This means supplementation does contribute to the well-being of your child.
Ensures to Meet Nutrient Needs
It is not a myth that our diet does not contain all the nutrients that we need. More often than not we are not getting the daily value for all vitamins and minerals as most of us are not able to monitor our eating habits. Also, we don’t have control over how sources of these nutrients change as they undergo the process of heating foods and other cooking preparations. With children being so picky, it is not surprising that they are susceptible to malnutrition. On the other hand, supplementation has been supported by decades-old research to meet the nutrient needs of individuals, including children. If you decide on giving your child multiple vitamin and mineral supplement, do check the label to make sure it says it contains 100 per cent of the recommended dietary intake of all nutrients.
Affects Growth and Development
A number of nutritional supplements available today have been proven to be of utmost help to the reversal of many medical signs and alleviation of diseases. Some of them have been associated with having a positive effect on the chemical reactions within the human body, and multiple vitamins and mineral supplements belong to this category. There is an ever-growing body of literature devoted to the interactions of exogenous compounds within the human body. Research on multivitamins in particular is among the most advanced in pharmacology, with emphasis on how the body effectively digests and absorbs them. Since the availability of vitamins and minerals is important to the physical and mental development of children, modern-day technology focuses on their absorption.
Strengthens Immune Defenses
There is scientific consensus that micronutrients, even trace minerals, boost our immune system. In fact, in individuals who have compromised immune responses, high quantities of vitamins and minerals slow down the progression of opportunistic diseases, as is the case with children with HIV. Children who have strong immune system are known to have levels of micronutrients adequate to ward off common illnesses. The opposite is also true. Multiple vitamin and mineral supplements have long been used to combat the dire effects of malnutrition as deficiencies are almost always reversed with supplementation. That being said, prevention is always better than cure.
Ensure you are getting the daily vitamins and minerals you need to maintain good health with a quality multiple vitamin and mineral.
What is stopping you from taking a multiple today?
How Does the Herb Holy Basil Help with My Health?
March 10, 2011 02:04 PM
Author: Darrell Miller
Subject: How Does the Herb Holy Basil Help with My Health?
Holy Basil And Cholesterol, Inflammation, and more
Ocimum tenuiflorum, known as Holy Basil in the vernacular, is an herbal plant indigenous to South Asia, where it is called Tulsi. It is widely distributed across the subcontinent of India and surrounding countries and is primarily cultivated for its age-old medicinal benefits in addition to its religious significance to Vaishnavite practices of Hinduism. It has earned popularity as a health tonic over the centuries, and recent studies have supported its positive effects on human health. Today it is often associated with lowering cholesterol and glucose, acting as an antioxidant, and regulating inflammatory intermediaries.
Counteracts Stress Factors
The juice of holy basil has long been reputed to display adaptogenic properties. There have been countless accounts of its effectiveness in combating stress. In fact, the most compelling of all anecdotal evidence has something to do with its ability to create a feeling of wellness right after ingestion, the same tonic benefits attributed to ginseng. To date studies point to its homeostatic effects on the stress hormone cortisol, creating homeostatic effects on its metabolites and their interactions with compounds released in response to stress.
Neutralizes Free Radicals
Holy basil has been observed to show antioxidant activities, and this is one of its mechanisms in allaying symptoms brought on by fatigue. Free radicals are released by the body to dispose of pathogens, but are in turn disposed of by endogenous antioxidants. Oxidative stress ensues when there is an imbalance between the production of free radicals and the ability of the body to neutralize them. The polyphenols found in holy basil helps the body quench excesses of free radicals.
Lowers Bad Cholesterol
There has been a growing body of literature devoted to the lipid-lowering properties of holy basil. The phytochemicals found in holy basil have been cited to affect the metabolic pathway that produces very-low-density lipoproteins, which is a precursor to low-density lipoproteins, or bad cholesterol, and bring about an increase in high-density lipoproteins, dubbed good cholesterol. Also, it has been associated to the overall decrease of lipids present in the bloodstream, notably free fatty acids.
Reduces Blood Glucose
One of the earliest observations on the health effects of holy basil is its properties that counter the progression of diabetes. It has been reported many times to have helped patients of type 2 diabetes mellitus, which results from the compromised ability of cells to respond to the hormone insulin. The use of holy basil extracts has yielded promising results on promoting the glucose uptake of cells, and, of course, the consequent decrease in glucose present in the blood.
Holy basil has been extensively studied for its anti-inflammatory benefits. The most recent research has pointed out that organic compounds found in holy basil may inhibit the enzyme called COX-2, which facilitates the synthesis of inflammatory mediators. Eicosanoids are endogenous substances produced by local tissues during inflammation, and a special group called prostanoids is responsible for the pain tied to inflammation. By targeting COX-2, holy basil greatly aids against inflammatory diseases such as arthritis.
What is stopping you from giving holy basil a try today?
Did You Know without Magnesium, You Could not Survive?
February 16, 2011 02:04 PM
Author: Darrell Miller
Subject: Did You Know without Magnesium, You Could not Survive?
Magnesium and your Health
Magnesium is vital to life on all levels. All types of cells in all organisms must maintain a balance of magnesium to support life as we know it, and its presence in human beings is ubiquitous at a cellular level. Low levels of magnesium have been tied to a number of medical conditions such as asthma, diabetes, and osteoporosis whereas excesses are known to impair functions of tissues and organs, notably nerves cells and the kidneys.
Supplies the Human Body with Energy
Glucose is best known as the primary source of energy of most multicellular organisms, including of course human beings, while adenosine triphosphate, or ATP, is the form of energy yielded by the utilization of glucose within the cells. All forms of carbohydrates and fats from our diet must be broken down into simpler compounds to be able to be converted into ATP that powers cellular activities.
That being said, ATP requires magnesium in its participation in a number of physiological functions. What we refer to as ATP in fact contains ions of magnesium, for the former must be chemically bound to the latter to perform its role in interactions with protein kinases. In fact, it is a common observation that magnesium almost always acts as the functional regulator in the binding of proteins with ATP.
Participates in Enzymatic Reactions
More or less 300 hundred enzymes in the body are dependent on ATP, which we refer to as coenzyme, a kind of chemical compound that binds to protein. Magnesium acts as glue that keeps the enzymes and ATP together, aiding in the catalytic activities brought about by the enzymes and their utilization of ATP. Thus, the metabolic pathways that employ these enzymes rely on the presence of magnesium.
One example of the interaction of ATP with proteins that necessitate magnesium as a divalent cation, in other words functional regulator, is in enzymes that modify the molecular structure of other proteins. These enzymes are transcribed in more than 500 protein genes and affect up to 30 per cent of all proteins in the human body. Moreover, magnesium plays a role in ribosome, the cellular component responsible for creation of RNA copies and the manufacture of proteins.
Magnesium Facilitates Absorption of Calcium
Over 60 per cent of magnesium in the body is stored in the bones, and this fact has become the basis of the recent trend of dietary supplements that utilize magnesium to induce healthy bone density. Indeed low levels of magnesium has been reported to contribute to the degeneration of bones as we age, resulting in porous bone particles in a medical condition called osteoporosis.
Prevents Ailments of the Circulatory System
Since magnesium is essentially everywhere in the body, it significantly impacts the overall health of the circulatory system, notably in the prevention of heart diseases. Not surprisingly, insufficient levels of magnesium have been documented to cause cardiovascular problems, including hypertension and congestive heart failure, and supplementation of magnesium has been noted to cut complications of preexisting circulatory conditions.
Have you had your magnesium today?
Bromelain Supplements why?
November 06, 2010 10:32 AM
Author: Darrell Miller
Subject: Bromelain Supplements why?
Bromelain enzyme may not be as familiar as other digestive supplements to most people but this helpful catalyst offers a wide range of benefits not only to the digestive system but also to other systems of the body.
Bromelain Enzyme Supplement
Bromelain enzyme is a proteolytic digestive catalyst that contains sulfur. From the word “proteolytic”, this substance aids in the digestion of proteins especially when taken with meals. On the other hand, when taken without meals, it is deemed to act as an anti-inflammatory supplement. Ananas comosus or the pineapple plant is the best source of this beneficial enzyme. However, fresh pineapple extract does not contain doses high enough to have a medicinal effect. Hence, a preparation to meet the body’s demand is produced. Bromelain supplements now come in the form of tablets and topical creams. They are now widely available and affordable to counterweigh the several uses it offers.
In the Digestive System, bromelain enzyme does not only help in digesting proteins but may also relieve gastric upset and heartburn especially when used together with other digestive enzymes like amylase, a catalyst responsbile for carbohydrate digestion, and lipase which is for the digestion of fats. Diarrhea conditions associated with deficiency in the proteolytic enzymes can also be alleviated with the use of this supplement.
In the Immune System, bromelain has been widely considered as an effective relief for pain and swelling caused by both injury and certain infections. Studies frequently show the bromelain’s ability in facilitating the body to restore health more quickly. The mechanism is said to be a reduction of fibrin and leukotriene accumulation, thus regulating the inflammation process. Researchers have demonstrated evidences that a daily intake of 1,200 to 1,800 mg of bromelain may help alleviate painful inflammation just like in rheumatoid arthritis.
In the Cardiovascular System, bromelain supplement is theorized to play a role in the prevention of heart disease caused by atherosclerosis or thickening of the arterial wall due to plaque deposits. It slows down the clumping of platelets thus preventing a possible heart attack.
Bromelain May Also Relieve Pain
Lastly, bromelain may also relieve pain associated premenstrual syndrome and menstraul cramps. Studies reveal that they act as prostaglandin inhibitors. However, bromelain can also increase the bleeding during menstruation.
Bromelain supplement has no Recommended Dietary Allowance but doses of up to 1 gram taken 3 times a day showed no toxic effects. Experts also advise to take bromelain on an empty stomach supplemented with magnesium to increase the bromelain’s effects.
Just like any other drug or food supplement, bromelain also has side effects, nonlife-threatening to be exact. It may have drug interactions such as increasing the absorption of some medications like antibiotics, chemotherapeutic drugs and specific antihypertensive agents. In addition, it may also bolster the effects of blood thinners such as warfarin (Coumadin), anti-inflammatory drugs and antiplatelet agents such as clopidogrel (Plavix). Since bromelain supplement can cause certain drug interactions, it is important to take this enzyme cautiously or under the supervision of a qualified health care provider.
To find quality bromelain supplements, look to your local or internet vitamin store.
June 18, 2009 10:54 AM
Author: Darrell Miller
After going through puberty, our bodies gradually decrease in the production of immune and growth factors that generally combat disease. After losing these vital components, we are much more susceptible to the aging process, which shortens our life expectancy. Colostrum and its other components have the ability to fight off bacterial and viral invaders as well as stimulate tissue repair, which is something that becomes increasingly vulnerable as we age by boosting the immune system. For all of these reasons, it is important for an adult to supplement with colostrum.
Colostrum should be collected during the first 24 hours after birth. Also, a colostrum supplement should be processed in a USDA licensed facility. This insures the consumer that USDA guidelines are being followed. Additionally, consumers should make sure that products labeled Colostrum are actually 100% colostrum, not colostrum or concentrates of milk whey. Lastly, colostrum that is mixed with other supplements or herbs and additives may have a diluted colostrum concentration, which means the benefits you could obtain from this supplement may be compromised.
Even though colostrum has no interactions with drugs, side effects may be experienced from a cleansing or healing crisis, which is a necessary but somewhat inconvenient and adverse result. Fortunately, once the healing crisis is complete, you will feel substantially better and in good terms of health. Mediations may need to be re-evaluated by your medical profession for dose and need.
Although colostrum is generally believed to be very safe for those mothers who are pregnant and nursing, one should probably ask their medical professional prior to taking colostrum or its specific agents while they are pregnant. Just like any other supplement or drug, it is better to be overly safe and check with a healthcare provider before jeopardizing a pregnancy.
Colostrum is recommended specifically for children who have not already received the mother’s breast milk, as breast milk would have already provided the benefits that would be obtained through colostrum supplementation. Those children with flu, colds, bacterial or viral infections, or children who have been on long or short-term antibiotics or other drugs are good candidates for colostrum supplementation. Therefore, colostrum supplementation is safe and may be recommended for these types of children.
Many people wonder if colostrum products can pass on mad cow disease. At this time, no case of mad cow disease has been reported in the United States. With awareness of the disease being so high, it is extremely unlikely that one would contract mad cow disease from a colostrum product.
The overall supplementation of colostrum and other products that contain derivatives of colostrum has been shown to extremely safe. Additionally, it has been shown that colostrum is equally effective, whether it be taken by injection or by mouth. It has also been shown that the long-term administration of colostrum preparation is very safe to the human body. Because infants and the elderly are the two main groups that are especially at risk for infections, many people may wonder just how safe colostrum products are for these two groups of people. Not only is oral administration safe, it is also very effective and easily accepted by both of these groups.
Colostrum is available in capsule of tablet forms at your local or internet health food store. Look for name brands like Kal and Source Naturals to ensure quality and purity of the product you purchase.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Colostrum is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
June 11, 2009 06:16 PM
Author: Darrell Miller
Subject: Boswellia Extract
The boswellia family of trees are specifically known for their fragrant, gummy sap, which possesses many medicinal uses. Among these, especially, if the use as an anti-inflammatory. It is believed that the frankincense of the bible was actually an extract from the resin of the Boswellia tree. Boswellia, which is also known as boswellin, has a long history of use in Ayurvedic healing. The resin is called salai guggal and has been used to treat asthma, arthritis, various inflammatory conditions, and to relieve joint pain and pain that results from sports injuries. The resin of the boswellia tree is also though to be helpful for treating back pain as well as some other chronic intestinal disorders.
The boswellia plant is a genus of trees that are known mainly for their fragrant resin. This resin has many pharmacological uses, particularly as anti-inflammatories. There are four main species of boswellia, producing true frankincense. Each type of resin is available in various grades. These grades depend upon the time of harvesting. The resin of the boswellia plant is hand sorted for quality. Anyone who is interested in frankincense is advised to obtain a small sample from each reputable dealer to determine the difference between each resin.
Boswellic acids are the main compounds that are believed to be at the source of boswellia’s anti-inflammatory properties. These acids have the ability to inhibit the enzymes that induce pain and inflammation in the body.
A few studies have been conducted on boswellia’s effect on sports injuries and arthritis. Among these, some have shown that boswellic acids may contain anti-inflammatory benefits that are extremely powerful. These benefits are similar to those found in ibuprofen and aspirin. One study done on rheumatoid arthritis patients found that pain and swelling were reduced after three months of treatment with boswellia. Those who used boswellia occasionally reported mild gastrointestinal distress, like heartburn and nausea, but there were no other reports of serious side-effects.
Boswellia has a long tradition of safe and effective use as a mild anti-inflammatory to alleviate pain and stiffness. It is also used to enhance mobility without serious side effects. However, further research is needed to confirm the long-term safety and effectiveness of this extract. Boswellia seems to be best taken as needed in order to reduce pain and stiffness, as opposed to being taken regularly as a maintenance herb.
The resin of boswellia is used in many herbal formulas because of its analgesic and anti-inflammatory properties. Primarily, this extract is most useful in dealing with arthritis, asthma, inflammatory conditions, joint pain, and sports injuries.
A boswellia standardized extract is recommended by many doctors. When dealing with rheumatoid arthritis or osteoarthritis, 150 mg of boswellic acids are taken three times per day. For example, if an extract contains 37.5% boswellic acids, 400 mg of the extract would be taken three times daily. Treatment with boswellia should generally last between eight and twelve weeks. Generally, boswellia is safe when used as directed. Rare side effects include diarrhea, skin rash, and nausea. Any inflammatory joint condition should be closely monitored by a health care professional. To date, there are no well-known drug interactions with boswellia.
Boswellia comes in capsule form at your local or internet health food store. When making a purchase always read the label to ensure that the product is standardized to its active acids to ensure quality and purity and to ensure that the herb when taken regularly will function as intended.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Boswellia is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
January 29, 2009 03:52 PM
Author: Darrell Miller
Some companies are already manufacturing a blend of cheaper ingredients with hoodia, and claiming it is better than hoodia alone. This means that you might find a product that contains 1,000 mg of total ingredients, but it could contain as little as 50 mg of hoodia. As a general rule, the other ingredients are only included to make the product cheaper. All hoodia supplies are the same strength worldwide. The stems of the plant are picked, dried, and milled, leaving a powder about 5 percent of the original weight, which is why some quote it as a 20:1 extract. However, don’t be misled. Despite what a label may lead you to believe, you’re only getting 50 mg of hoodia.
The minimum dosage that is necessary to have a usable effect is about 800 to 1,200 mg of actual hoodia each day. This amount will help to reduce your appetite so that you can eat smaller meals and, consequently, lose weight. If you think you’d like to try hoodia, look for a product that has been naturally extracted and grown or ethically wild crafted without the use of chemical fertilizers, pesticides, or preservatives, preferably in a vegetarian capsule.
Make sure that the product you use is a true standardized full-spectrum herbal supplement that does not include any fillers, binders, or common allergens. Also, keep in mind that even though safety reports to date are encouraging, no long-term safety studies have been performed. Additionally, there is no data on the possible interactions hoodia may have with other drugs.
Hoodia is a non-stimulating herb, which makes it more suitable for a large range of people. Herbal stimulants such as guarana or kola nut, which both contain caffeine, can cause a large range of side effects such elevated heart rate and blood pressure, nervousness, and sleeplessness. P57, the active ingredient in hoodia, has no sedative effects.
Losing weight and maintaining an ideal weight also requires changing attitude and lifestyle. If your main goal is to quickly lose weight so you can fit into your bathing suit, you may be able to achieve that lighter weight, but without exercise, you’re still going to look flabby. Even though the subjects in the hoodia clinical study did not exercise, you should, as exercise plays an important role in losing and managing weight along with overall health.
Weight loss should be about your overall health. Without the proper eating habits, especially nutrition and exercise, you won’t be able to accomplish much. It’s true that less weight puts less stress on your cardiovascular system, but you need to exercise to strengthen your heart muscles. Proper nutrition and exercise also helps to prevent many other health problems, which includes fighting off many digestive ailments.
If you’re considering trying hoodia for weight loss, experts suggest that you supplement with 800 to 1,200 mg a day, divided into two doses and taken with water. For best results, follow the manufacturer’s dosage instructions since products may vary. You should also follow a reduced-calorie diet of natural, unprocessed foods. Even though you can probably lose weight on a diet like this without supplementing with hoodia, adding hoodia may help you to stick to your diet better.
June 17, 2008 10:47 AM
Author: Darrell Miller
Subject: Chromium Picolinate
Chromium picolinate, broken down, is chromium that is bonded to an amino acid. The chromium portion of the compound is not well absorbed by the body. Therefore, the amino acid picolinate is added to aid in absorption.
Studies have shown that 90 percent of the adult population in the United States has a chromium deficiency in their diet. The best source of chromium is true brewer’s yeast, but it is found in grains and cereals in smaller amounts. Refined forms of these foods are likely to be lacking in sufficient chromium levels. Strenuous physical activity requires a larger intake of chromium in the diet.
Chromium picolinate, a chromium supplement, has profound effects on the body’s overall nutrition and health. It has increased in popularity in recent years because it helps to reduce body fat and increase lean body mass. Research has proven that it can aid in treating:
* High blood sugar
* High blood fat
* Food cravings
* Lack of energy
* Trouble controlling weight
* Low metabolism
In the late 1950s, chromium picolinate was discovered to be essential for proper blood sugar control. It is a key part of desensitizing the body to insulin. Without chromium, blood sugar levels are elevated because insulin is blocked from doing its job. Chromium is one of the essential trace minerals. Its most important function is to work with insulin, which is a hormone. Insulin is responsible for the body’s ability to break down carbohydrates, proteins and fats naturally. Your metabolism affects every cell in your body. All bodily functions are dependent on the proper use and breakdown of these chemicals.
A deficiency of chromium in your diet will lead to an impairment of insulin activity. This insulin resistance allows more glucose to remain in your body, resulting in weight gain and loss of energy.
Insulin is the most important hormone involved in metabolism. Everyone’s body requires proper insulin function to be healthy. Insulin is secreted whenever you eat. It then binds to cells to activate sugar absorption from your bloodstream. The body’s sugar (glucose) is its strongest energy source. The cells use it to fuel the body’s essential functions like metabolism and building muscles.
Because of these needs, chromium picolinate can be used as a supplement to promote weight loss and treat high cholesterol and diabetes. It is an essential supplement for healthy metabolism, especially in older people. People who lack enough chromium picolinate in their diets usually have trouble keeping weight off and feel run down regularly.
Chromium Picolinate and Weight Loss:
Chromium picolinate is not a viable quick fix for permanent weight loss. It is, however, a valuable addition to a healthy and well-designed weight loss program. People who are overweight are generally insulin resistant. For this reason, additional chromium supplementation aids in healthier metabolism and more productive use of insulin. The result is increased weight loss when used in conjunction with proper exercise and a well-balanced diet.
Dietary Interactions and Safety:
Chromium picolinate has been shown in studies to be safe for use with most medications. However, as with any dietary supplement, it is important to discuss your use of this supplement with your physician before planning any dietary changes.
Chromium picolinate was safe in studies in which it was used in amounts exceeding 500 times the recommended daily dosage. The production of this dietary supplement is under the highest quality and safety conditions available. No side effects have been reported since chromium picolinate has been available on the market.
Most daily multiple vitamins contain the recommended daily allowance of chromium picolinate. However, since it is so difficult for the body to absorb effectively, most people need more supplementation than is generally recommended.
May 16, 2008 02:12 PM
Author: Darrell Miller
Subject: Coral Calcium
The health benefits of coral calcium were discovered in 1979, when a British journalist representing the Guinness Book of records traveled to Okinawa to talk to Shigechiyo Izumi, who at 115 years old was at the time the world’s oldest documented living human being. Not only was the journalist impressed and surprised at how healthy such an old man was, but he also found that good health to be shared by the majority of Okinawa’s aged residents.
After his report was filed on his return to England, a team of researchers were sent to the island to make further investigations in the phenomenon. They found that the key to their longevity was the water they were drinking. The water of Okinawa appeared unique, and coral calcium was discovered.
It was not only the calcium, of course, that made such as difference but the whole mineral balance of the water. Okinawa is formed of coral reefs built up over millennia, and rainwater filters down through the coral collecting minerals and other nutrients on its way. This water is both alkaline, with a pH of 8.6, and closely resembles the natural mineral composition, not only of the human skeleton but also of body fluids such as blood plasma and amniotic fluid. It seemed the ideal stuff to bottle, and there are now over 4 million users of coral calcium in Japan alone.
The commercial use of Sango coral, as it is called, is controlled by the Japanese government, and living coral is left untouched: only the dead coral sand lying on the ocean bed is used. The sand is collected and cleaned, and then pulverized and the calcium and all the rest of the minerals it contains are easily absorbed by the body.
It is this ease of absorption that renders coral calcium so useful. Most minerals find it difficult to pass from the intestine to the bloodstream, but this is not a problem for the minerals in Sango coral. Because they do not come from inorganic mined minerals, but from natural organic sources, they are present in a very bio-available form and are readily absorbed into the bloodstream. It not only contains the common minerals calcium, magnesium, potassium, sodium, and so on, but also many trace elements that are essential for life. Not only that, however, but they also contain antioxidants to help prevent the oxidative stress caused by free radicals, and also at a pH that allows the minerals to become naturally ionic very readily.
It is this ionic form of each mineral that permits it to be so readily available to your system. This was a major discovery at the time, since the form that inorganic minerals generally come in had been a problem prior to this to the extent that only 10% was absorbed by the body. In comparison, 95% of the coral calcium and other minerals are able to be easily absorbed since they are in an ionized form – an even higher absorbency than colloidal minerals allow.
Why are minerals so important and how can they possible lead to such an effect on the elderly of Okinawa? In fact minerals are very important components of human metabolism and biochemistry. Most believe vitamins to be significantly more important to human health than minerals, but this is not the case. Many vitamins are useless without the synergistic effect of minerals, and the reverse is also the same.
For example, calcium needs vitamin D to be present before it can be used by the body to strengthen bone structure. There are many other such interactions involving vitamins and minerals, and without chelation (the rendering of large organic molecules to a soluble form by combining them with metal ions) many of the essential biochemical processes of life would be impossible. Coral calcium contains all the minerals found in your body, and in very similar proportions, so that you are able to use it to maintain that all important synergism and not throw the mineral balance of your body out of balance. This is very easy to do if you take individual mineral supplements.
However, there is still more to come from this remarkable substance. It is also rich in antioxidants that spell death for free radicals. Free radicals can’t really die, because they are not living entities but molecules that have a free electron, and free electrons like to pair up with other electrons. Free radicals are therefore very aggressive when near any body cell from which they can rob an electron, and that, unfortunately, destroys the cell.
Not only that but they also oxidize molecules from which they take the electron, and if that is a low density lipoprotein, or LDL, that happens to be carrying some cholesterol to one of your arteries that needs a bit of repair work, then it will cause the LDL to deposit the cholesterol immediately and form plaques that constrict and narrow your arteries. That is called atherosclerosis and it can kill you or give you a stroke. Cholesterol is essential for good health, but once the free radicals get to work you are better without it.
However, Sango coral contains substances that prevent the free radicals from oxidizing other substances, and in so doing destroy them. That’s what antioxidants do. They prevent free radicals from oxidizing other molecules and creating all sorts of havoc with your health. Excessive amounts of free radicals have been associated with over 80 different conditions, and one of the benefits of coral calcium is that it is one of the most powerful antioxidants known.
It is not only the mineral content and antioxidant properties of coral calcium that are of benefit to the human body, but also its pH. The various fluids of your body are maintained at a specific pH, which is a measurement of the acidity or alkalinity of a fluid. This should be slightly alkaline without being caustic. If your body fluids are too acidic it becomes difficult for you to absorb minerals and vitamins, and it is essential for you maintain a balance of from around 6.4 to 7.0 Any lower than that and you will find it difficult to sleep and you will feel listless with no energy.
You can measure the pH of your body by testing your urine with pH strips available at any pharmacy. Coral calcium can be used to maintain a good pH level that allows your body to absorb the nutrients it needs, and keep you feeling not only well, but young and sprightly just like Shigechiyo Izumi did at 115 years old.
Vitanet ®, LLC
Grapefruit Seed Extract
May 06, 2008 05:14 PM
Author: Darrell Miller
Subject: Grapefruit Seed Extract
Grapefruit seed extract is regarded as being natural antibiotic that is effective against a broad range of bacterial infections. It has also been used to treat parasitic infections and a range of viral infections as well as having found uses for a wide variety of medical conditions.
So what is it about grapefruit seed that is so special? Most people are acquainted with grapefruit, which as a member of the citrus family of fruits, and not to be confused with grapes which are a totally different type of plant. Grape seed extract is also a useful natural medication, but used for totally different conditions.
Because of its efficacy against parasitic and viral infections, grapefruit seed extract is very useful in treating various forms of food poisoning. But, how was this remarkable property of the simple grapefruit seed noticed? The answer to that depends very much upon what version of the story of Einstein Laureate physicist and immunologist Dr. Jacob Harich you believe.
Dr. Harich was not only a scientist but a hobby gardener in Florida, and the two versions of his story tell either that he decided to investigate why grapefruit seeds tasted so bitter, or why the grapefruit seeds in his compost heap failed to compost, or rot. Whichever story is correct, and perhaps both are, the result was the discovery that grapefruit seeds appeared to be a very effective antibiotic.
In fact it has been shown to be effective against over 800 strains of bacteria and viruses and also effective against many fungi that lead to illness in humans. Because of this it is used in cased of food poisoning that involve bacterial infection of the gastrointestinal tract. In fact during the latter part of the 1980s, grapefruit seed extract was tested against a number of known antibiotics and found to be as effective as any of them. Similar results obtained in a number of tests in the USA and elsewhere in the world, and it appears that it is an excellent treatment for the symptoms of food poisoning.
Not only that, but it has been found effective in the treatment of some immunodeficiency diseases, presumably because its antimicrobial properties does much of the work that the immune system would normally do, and so relieves it of much of its hard work. This allows the immune system to concentrate on conditions which are exacerbated by deficiencies in its operation.
Bifidobacteria and Loactobacilli are bacteria that are beneficial to the digestive system. The measure of a good broad spectrum antibiotic is that it does not affect the beneficial bacteria, and grapefruit seed extract has no effect on the former and only a mildly inhibiting effect on the latter. It is also non toxic to humans, which is another measure of a good antibiotic. You would have to drink about two pints of the extract, around 4000 time the normal dose, for the treatment to be potentially fatal.
Among the many uses of the extract are not only in controlling gastrointestinal infections, but also general fungal conditions of the skin, vaginal infections and yeast infections, and also colds and sore throats. It is also believed to support the immune system, not only by its antimicrobial properties but through its effect on intestinal health upon which much of our immune system is dependent. It can also protect patients with symptoms of AIDs and other immunodeficiency conditions from infection.
Its effect on yeast infections around the nether regions of small children has been documented, and it has also been found to be very safe to young children. In fact many mothers have it as a permanent addition to their medicine cabinet.
It is not that long ago when doctors believed all diseases to be due to bacteria or viruses. It is now becoming clear that a large proportion is actually due to fungal infections and parasites. Many conditions such as allergies, circulatory disease and some forms of arthritis have been shown to be due to fungal infections that weaken the immune system. Grapefruit seed extract has been found to be effective in treating many types of fungal disease.
In using the extract in this way, and to treat bacterial infections, it is best to start with a low dose and gradually increase it. This is because when fungi and bacteria are destroyed they release toxins, and too high a dose could result in too much toxin being produced for your body to handle. If you take it gradually you will get the same result, but without the risk of the nausea and diarrhea which the toxins can cause.
Despite all of these benefits, grapefruit extract has not been given the credit it deserves, and much research has still to be done to establish the constituents of the seed that confer these properties. Among these are known to be proanthocyanadins, a class of flavanols with strong antioxidant properties, and a diphenol hydroxybenzene complex that destroys bacteria through the cytoplasmic membrane to prevent the uptake of amino acids and cause leakage of the cell contents. Other active components are Vitamins C and E, tocopherols, limonoids and sterols, in addition to a number of important minerals.
However, there is still much work to be done, although the extract will continue to be used by many devotees for the treatment, not only of food poisoning symptoms, but also of conditions such as acne, athlete’s foot, gingivitis, cold sores, sinusitis and parasitic infections. It appears to be practically a cure-all.
There appear to be no drug interactions, although some medications do react with grapefruit juice, such as some treatments for high blood pressure. If your treatment advises you not to take grapefruit juice, then do not take grapefruit seed extract. Another factor to be aware of is that since the extract is an effective bactericide, then it could deplete the digestive tract of friendly bacteria essential for digestion. You are advised, therefore, to take a supplement of acidophilus, which is easily taken in the form of yoghurt type drinks specifically formulated or dietary supplement for the purpose.
Vitanet ®, LLC
Benfotiamine A Natural Solution Or Miracle Substance To Control Blood Sugar?
February 19, 2008 04:25 PM
Author: Darrell Miller
Subject: Benfotiamine A Natural Solution Or Miracle Substance To Control Blood Sugar?
The term "miracle" has been in use for hundreds of years when it comes to products that are claimed to aid health. Does this mean that it's always false? Not necessarily. Occasionally a seemingly "new" product will enter the spotlight and draw the attention of the public. Often, after a series of tests and trials, these products fade into oblivion because they didn't actually perform in the ways purported. There are exceptions to this rule; as with the supplement benfotiamine.
Benfotiamine is a natural solution to many problems in the human body. This product is one of nature's best sources of thiamine; or B-1. The FDA has approved this additive as a dietary supplement. Vitamin B-1 is a necessary substance in the body because it maximizes the results of your carbohydrate intake. It also helps with stress, improves your mental health and strengthens your general nervous system.
Benfotiamine is commonly found in trace amounts within such substances as roasted garlic, onions, leeks and shallots. Many years ago, a Japanese pharmaceutical company attempted to bring attention to this substance. Unfortunately, their efforts gained little traction. Recently, a physician produced a published article detailing the benefits of benfotiamine and since then the product has rapidly gained popularity.
This product has been tested for individuals with conditions pertaining to diabetes, but the full scope of clinical testing does not end there. Benfotiamine has been tested for decades for its effects and capabilities in helping all types of conditions.
For those with diabetes, this substance has been reported to alleviate sciatica as well as improve general cellular and circulation health. Neuropathy is a painful condition encountered by individuals with diabetes. There are several other related conditions that have all responded well to this supplement.
This supplement has helped many with diabetes, but also helps those without it. This supplement has also been reported to have benefits for: nerve health, improved blood pressure, fibromyalgia and has been used in the treatment of Alzheimer's disease. It has been suggested that benfotiamine contains many anti-aging properties that help the body.
Vitamin B-1 is reported to combat motion sickness. It helps in the treatment of the painful condition known as "shingles," helps lessen post-operative dental pain and even repels biting insects. B-1 is found naturally in many products including whole wheat foods, dairy products, peanuts, oatmeal and rice husks.
Benfotiamine has no known interactions with prescription medications and, in turn, helps replenish the body with thiamine. There are some prescription drugs that will cause a B-1 deficiency if no supplements are taken.
Benfotiamine is lipid-soluble (or fat-soluble) and this quality means the idea of "overdosing" is nearly impossible. It metabolizes quickly and does not build up in the human body. There are certain individuals who require a higher dose to be most effective. Those who love caffeine, who are pregnant, who smoke or drink alcohol may have a B-1 deficiency.
There are many forms of this product, but capsules seem to be the most common outside of the food groups. The effects are noted to take anywhere from two to three weeks to fully develop. If you are interested in starting a regimen of benfotiamine, or any supplement, consult your physician first.
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Natural Hormone Balance for Women
December 25, 2007 11:18 AM
Author: Darrell Miller
Subject: Natural Hormone Balance for Women
The majority of women are affected by moderate-to-severe menopausal symptoms and premenstrual syndrome (PMS) at some point in their life. PMS that is clinically diagnosed consists of symptoms that are so severe and pervasive that careers, social interactions, and family lives are negatively affected. This occurs in eight to twenty percent of women in the Western world. Menopause and PMS are both characterized by a severe fluctuation or major falling of the female hormones estrogen, progesterone, and prolactin. Since many examples of women who are barely affected by natural changes exist, it can be logically inferred that female hormones are capable of remaining close to balanced, while others experience hormones that swing abruptly from one extreme to the next, causing severe mood swings. Although changes in hormone levels are the reason menopause and PMS occur, women do have some control over the severity of their symptoms.
There are many natural approaches to hormone balance along with other medical interventions that can be used either separate or together. However, one must remember that women are biologically programmed to have multiple children, which therefore, would limit the number of menstrual cycles in a lifetime. Additionally, women are now living thirty years past menopause, an experience that is relatively new. Also, a lot of the pain and anguish that is associated with menopause and PMS is actually related to obesity, high-calorie eating habits, and inactivity. Normal body weight and regular exercise often leads to mild or inconsequential PMS.
In 2002, estrogen and progesterone hormone replacement therapy, which is the standard treatment for menopausal symptoms, came under scrutiny after the publication of research that found that supplementation of estrogen significantly increases the risk for breast and ovarian cancer. Supplementing estrogen also does not protect against cardiovascular disease. As a result, US-dispensed prescriptions for estrogen declined from ninety-one million in 2001 to fifty-seven million in 2003. It has been found that a lot of the excess risk for breast and ovarian cancer was due to prescriptions being refilled indefinitely instead of hormone replacement therapy only being used at the onset of menopause. Additionally, supplemental estrogen was not paired and balanced with progesterone, causing a greater risk. Either way, the door to natural alternatives was opened wide, especially for those patients who have a family history of reproductive cancer. Natural therapy for menopause and PMS is based upon phytoestrogens.
Phytoestrogens are plant compounds that contain chemical structures which resemble estrogen. These plant compounds can exert weak estrogenic or antiestrogenic effects. Isoflavones from legumes such as soybean, red clover, licorice, as well as lignans like flaxseed and milk thistle are the most common and familiar phytoestrogens. Black cohosh has been shown to have antiestrogenic effects only. Phytoestrogens have been proven to reduce the risk for estrogen-dependent breast, uterine, and ovarian cancers as well as hot flashes, night sweats, and sleep disturbances. Although phytoestrogens do a good job at protecting women from symptoms of excess estrogen, phytoestrogens cannot replace estrogen when there isn’t enough. They don’t help with vaginal wall atrophy and dryness, thinning hair, lack of sexual desire, menopause-related urogenital itching, or infertility. For the best results, supplements of soy and red clover isoflavone should be taken 2-3 times daily. Although there are no herbal alternatives that actually raise levels of estrogen, natural medicine such as dong quai, licorice, milk thistle, ginseng, pycnogenol, and pollen for menopause and calcium, magnesium, B6, chastre tree, dong quai, and ginseng for PMS can balance existing female hormones and provide relief from symptoms.
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Natural Vitamin and Herbal Alternatives For Joint Health
October 18, 2007 03:58 PM
Author: Darrell Miller
Subject: Natural Vitamin and Herbal Alternatives For Joint Health
Joint tissue breaks down and arthritis sets in for a number of reasons, and there are several natural alternatives for joint health that can be use to prevent this and to treat affected joints.
Thyroid problems can slow down the production of adrenal hormones that are responsible for the production of cortisone and cosrtisol. These are anti-inflammatories, that when unavailable or in low supply can result in joint inflammation. If you suffer joint pain in the mornings that tends to improve as the day goes on, then it is likely that is the cause since adrenal activity can improve as the day progresses.
One of the main reasons for joint tissue breakdown is osteoarthritis whereby the cartilage wears down until it fails to provide the necessary protection against impact between the bones in a joint, or against the friction generated when two bones rub together. Injuries to joints can have the same effect, whereby an injury to a hip or knee can appear to clear up and then later the cartilage wears out sooner than expected. This can take several months or many years, depending on the severity and nature of the injury concerned.
Continual wear and tear can also cause joint tissue to break down. Athletes and other sportspersons often suffer twenty years or more after retirement from their sport due to the gradual wearing down of cartilage while they were active. Once they stop, this continues to a lesser extent until the cartilage is eventually worn away sufficiently for it to stop protecting the joint.
Problems with the auto-immune system can lead to rheumatoid arthritis and inflammation of the joints. This weakens them and can eventually completely destroy the tissue. In such cases the tissues in the joint tend to swell and become extremely painful. Gout can also damage joints, especially in the big toe. This is caused through a built up of needle sharp uric acid crystals. Another cause is a deficiency in sodium and potassium in the diet that are needed to help maintain calcium in solution. When these metals are in deficiency due, for example, to an adrenal problem or some other reason, calcium can deposit right in the joints, causing undue pain.
Calcium and vitamin D deficiencies are commonly associated with arthritis sufferers, and protein deficiencies are also believed to be a contributing factor of rheumatoid arthritis, and it is also true that degenerative arthritis can accompany rheumatoid arthritis. This occurs in almost 40% of cases, and diet and nutrition are now being recognized as a major cause of both types. Deficiencies in folic acid or its natural form of folate, vitamin E, zinc and selenium have all been associated with degeneration of joint tissue, so it makes sense that a supplement of these substances can help to avoid these conditions.
Standard medical treatment, however, is for the relief of pain and reduction of inflammation through the prescribing of non-steroidal anti-inflammatory drugs (NSAIDs). Typical NSAIDs are aspirin, ibuprofen and naproxen. Although it relieves pain, paracetamol is not an anti-iflammatory. An alternative to blocking the inflammatory reponse is to help to regenerate the damaged joint tissue.
However, reducing the inflammatory response to tissue damage does not address the underlying problem, but masks it. Not only that, but there are side effects associated with the use of NSAIDs. Excessive doses can create serious gastrointestinal problems, such as bleeding, ulcer perforation and even death is possible in severe cases. Anti-inflammatories cause gastric problems in up to 20% of cases
The newer Cox-2 inhibitors act on the enzyme that causes the inflammation within the joint, and while these can be very effective, they are still masking the underlying problem. Incidentally, the Cox-2 inhibitors should not be used with NSAIDs, and both increase the possibility of a myocardial infarction or heart attack. Also, if you are taking aspirin to reduce the risk of heart problems, you should be careful not to use other NSAIDs since they can interfere with the effects of the aspirin.
More effective in the long run is to treat the conditions with substances that deal with the cause of the problem. Vitamin C, for example, improves the lubrication effect of the synovial fluid in the joints, and vitamin E is a strong antioxidant that can help to repair damaged tissue and improve the circulation within the joints. Joints have very low blood circulation levels, which is a problem when trying to direct drugs to the joint tissues. Vitamin C is also good for improving the integrity of connective tissue. Zinc, manganese and copper are also instrumental in developing strong connective tissue and helping to repair the damage done to the joints.
Horsetail is a commonly used herbal remedy that can be taken as a tea, tincture or in capsules. It is the richest natural herbal source of silicon, which is used by the body to form connective tissue and collagen. Damaged connective tissue is rapidly repaired by horsetail, and its strength and elasticity significantly improved. It is commonly used in the treatment of arthritis and osteoporosis.
Cat’s Claw is used for its beneficial effect on the immune system, and frequently used successfully to treat osteoarthritis and rheumatoid arthritis. However, this treatment is used more to help reduce the inflammatory effects of the condition than to effect a long lasting cure. Gotu Kola, also called Indian pennywort, is traditionally used for treating arthritis. The fresh leaves are effective in reducing the inflammation and pain, and help to improve the quality of life of arthritis sufferers. In Australia, it is referred to as ‘the arthritis herb’ and two leaves a day are said to be effective.
Another popular remedy is MSM (methylsulfonylmethane), although it is claimed to provide pain relief rather than a cure. Amino acids also seem to help, and L-cysteine helps promote collagen and connective tissue. It appears to work best when taken in combination with vitamin E and selenium that are powerful antioxidants. L-arginine has a similar effect in the reconstruction of joint tissue, again helping to repair damaged connective tissues.
There are therefore two approaches to treating both rheumatoid and osteoarthritis, one providing pain relief and reducing inflammation, and the other repairing the damage done to the joint tissues. Vitamins, minerals, trace minerals and herbal remedies are used in both, though it is better to use a combination that provides pain relief and also helps to regenerate strong connective tissues in the joints.
When using combinations of remedies it is important that possible interactions are understood, and you should always seek the advice of your physician when using non-prescription remedies of any kind.
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Peppermint Oil for IBS
March 24, 2007 11:01 AM
Author: Darrell Miller
Subject: Peppermint Oil for IBS
Irritable bowel syndrome (IBS) is a painful and frequently frustrating disorder of the intestines that’s often difficult to treat. Fortunately, there are scientifically studied natural products that effectively reduce the distressing symptoms of IBS.
Q. What is IBS?
A. IBS causes crampy pain, gassiness, bloating, and alterations in bowel habits. IBS is termed a functional disorder, because when the colon is examined, there is no visible sign of disease. While IBS causes significant pain and distress, no actual damage is occurring in the intestines.
There is a wide variability in IBS. Symptoms may be mild and fairly well tolerated. Or, the pain, discomfort, and bowel dysfunction may be disabling, limiting social interactions, employment, or travel.
While some individuals with IBS have diarrhea (frequent, loose stools with an urgent need to move the bowels), others have constipation (hard, infrequent stools that are difficult to pass). And, still others may experience both. Individuals with IBS also may have painful abdominal cramps and feel an urgent need to move the bowels, but are unable to do so.
Q. What causes IBS?
A. The small intestine receives digestive material from the stomach and delivers it to the large intestine (colon). About two quarts (2,000 ml) of digestive material enter the colon from the small intestine every day. The colon absorbs water and salts from the material, which is progressively moved through the colon. This progressive movement continues until most of the fluid and salts are absorbed into the body and stool is formed. The stool passes to the left side of the colon, where it is stored until a bowel movement occurs.
Because researchers haven’t been able to find actual damage in the colon, it once was suggested that individuals with IBS have emotional problems or are overly susceptible to stress. While stress may cause symptoms of IBS to intensify, it doesn’t cause the condition.
Recent study has determined the colon muscle of an individual with IBS spasms after only mild stimulation. It’s thought the symptoms of IBS are produced by hyperactivity of the intestines. In other words, the intestines of individuals with IBS are more reactive to stressors and diet than usual. Almost everyone has experienced abdominal queasiness in response to everyday stress or certain foods. This may result in a brief bout of diarrhea or an upset stomach. However, this response is exaggerated in individuals with IBS.
Q. How prevalent is IBS?
A. IBS is very common. In fact, it’s one of the most frequent problems seen by family physicians. It’s the most common disorder diagnosed by gastroenterologists (physicians specializing in the treatment of digestive disorders). The overall prevalence rates range from 10% to 20% of the general population in most industrialized countries. As a result, the pain and disabling symptoms associated with IBS result in significant socioeconomic costs, as wall as reduction in quality of life for many individuals.
Q. What are the symptoms of IBS?
A. Normal bowel function varies from person to person. Some people move their bowels daily, while others may only have two to three stools a week. A normal bowel movement is soft, formed, and is easily passed without cramping or pain.
IBS, however, causes abdominal cramps and pain, which are often severe and disabling. Bowel movements may be irregular and alternate between diarrhea and constipation. The diarrhea may be quite loose and watery. Mucous may be passed. There is often much straining, urgency, and feeling of incomplete evacuation (emptying). Abdominal bloating and passing of gas is common. Nausea, lack of appetite, heartburn, and belching may also be present. Sleep may be disrupted resulting in fatigue and lack of energy. Understandably, persons with IBS often feel anxious and depressed.
Diagnosis of IBS is usually based on the continuous presence or recurrence of these symptoms for at least three months. Other intestinal conditions must be ruled out. These include Chron’s disease, ulcerative colitis, inflammatory bowel disease, colon cancer, inflammatory conditions of the stomach or pancreas, ulcers, infectious disease, or gastroesphageal reflux disease.
Q. Are there clinically demonstrated natural alternatives to the over-the-counter drugs prescribed by my doctor?
A. Yes, both enteric-coated peppermint oil and clown’s mustard (in combination with other herbs) have significant scientific research behind them. Both have been demonstrated to benefit individuals with IBS.
Q. What is clown’s mustard and what does it do?
A. The scientific name for clown’s mustard is Iberis amara. Other names for this herb are wild candytuft and bitter candytuft. Clown’s mustard is a white-flowering plant from Spain, where it grows in dry soil on hillsides and in cornfields. It is also grown in Britain, France, and the United States. Iberis amara is a member of the Brassicaceae family. Iberis refers to its place of origin, the Iberian Peninsula. Amara means bitter. The key components of clown’s mustard are glycosides and flavonoids that have specific actions on gastrointestinal tract tone.
Q. Is there scientific evidence that clown’s mustard benefits people with IBS?
A. There has been very impressive research on clown’s mustard (in combination with other herbs). And, it has been used with great success in Germany for many years to treat IBS and other gastrointestinal diseases.
In a study of an herbal combination containing clown’s mustard, 20 patients were given the herbal combination for three to 32 days. They all had been diagnosed with chronic functional disorders for at least one to 20 years. The symptoms the patients experienced included pressure and pain in the abdomen, belching, heartburn, vomiting, nausea, fullness, lack of appetite, constipation, and diarrhea. The patients have been treated for their problems with a variety of antacids, anti-spasmodic agents, and motility-inducing substances. For the purposes of the study, the patients stopped taking these medications and received treatment only with the herbal combination.
Abdominal pressure and pain in the abdomen was the most common of all the experienced symptoms, with 11 of the patients rating it as severe. After six days of treatment, only sic of the patients continued to rate their abdominal pain and pressure as severe. After two weeks, this symptom had completely resolved for 16 of the patients. Diarrhea had been rated as severe in five of the patients. By day 14, only one patient continued to have moderate diarrhea.
Medications prescribed and taken for cardiovascular diseases, arthritis, and autoimmune diseases often cause gastrointestinal problems. Because these conditions are chronic, these medications must be taken for a long time, often for life. With long-term use, these medications can cause erosion of the stomach lining and actual ulcers. Many of these medication-caused symptoms are similar to IBS symptoms: pressure and pain in the upper abdomen, nausea, abdominal fullness, and lack of appetite. Most, if not all, of the individuals who have gastrointestinal problems caused from medications experience two or more of these IBS symptoms.
Forty patients who were taking medications for various types of cardiovascular disease and arthritis, and who are experiencing gastrointestinal problems related to their medications, were enrolled in a study. These symptoms included pressure and pain in the upper abdomen, nausea, abdominal fullness, and lack of appetite. Twenty patients received clown’s mustard combined with other herbs that support gastrointestinal motility. Three days after the trial started, a significant improvement of all s symptoms was noted in those taking this combination. By day 14, abdominal pressure and pain, nausea, and heartburn were completely eliminated in the herbal combination group. Several other clinical trials that were conducted in Germany report similar results.
Q. How does this herb compare to prescription drugs?
A. A study compared clown’s mustard (combined with other herbs) to Reglan (metoclopramide), which is frequently prescribed to reduce the symptoms of IBS. While metoclopramide is a very effective medication, it also has numerous side effects. Metoclopramide can cause fatigue, anxiety, agitation, jitteriness, insomnia, yellowing of the skin or eyes, changes in vision, hallucinations, and seizures. Because of these serious side effects, metoclopramide must not be taken longer than 12 weeks.
In comparison study, 77 subjects were randomized to receive treatment of either clown’s mustard in a combination with other herbs, or metoclopramide. All subjects had pain and pressure in the abdomen, cramping, abdominal fullness, nausea, heartburn, and lack of appetite. The subjects took 20 drops of their assigned treatment after meals three times daily. The duration of treatment was one to two weeks.
In both groups, a parallel improvement of all symptoms was observed. At no point in the study was a statistically significant difference in symptoms found. Both treatments significantly reduced pain and pressure in the abdomen, cramping, abdominal fullness, nausea, heartburn, and lack of appetite. In short, both metoclopramide and the clown’s mustard herbal combination worked well at reducing the symptoms of IBS.
However, side effects occurred more frequently and severely in the metoclopramide group. Given the lack of differences noted between the products at reducing symptoms of IBS, it would seem sensible to choose the treatment with the fewest reported side effects and no limits on duration of use.
Q. What evidence supports use of enteric-coated peppermint oil capsules for IBS?
A. Peppermint oil has been shown to relax intestinal smooth muscle. In Great Britain, peppermint oil is currently being prescribed for IBS by physicians and it has been used as a digestive aid and to soothe upset stomachs for generations.
Peppermint oil has also been studied for use in an important examination of the colon. A colonoscopy is a procedure of viewing the interior lining of the large intestine (colon) using a colonoscope, a slender, flexible, hollow, lighted tube about the thickness of a finger. A study published in the New England Journal of Medicine supports the idea that even people who are not at risk for colon cancer should have this test. The American Cancer Society recommends that men and women at average risk of colon cancer should have a colonoscopy every 10 years, beginning at age 50.
During a colonoscopy, individuals are sedated and almost no discomfort is experienced. The insertion of the colonoscope into the rectum and up through the colon causes some spasming. This is a natural and expected event and the physician performing the exam administers medications that effectively reduce the spasms.
A recent study compared the use of peppermint oil and commonly used medications to reduce the colonic spasming in colonoscopy. The peppermint oil was introduced directly into the colon. Effective reduction of colon spasming was observed in 88% of the patients.
In a critical review and meta-analysis of peppermint oil for irritable bowel syndrome published in The American Journal of Gastroenterology, eight randomized controlled trials were identified. The studies collectively showed peppermint oil is superior to placebo in improvement of the symptoms of IBS. Because of the good results of these trials, the authors of the review urged additional study of peppermint oil in IBS.
However, straight peppermint oil is rapidly absorbed into the blood stream from the stomach. In recent studies comparing enteric-coated peppermint oil capsules and non-enteric coated oil, both preparations provided effective symptom relief. However, the studies concluded the enteric-coated capsules delivered the benefit of the peppermint oil directly to the intestines. In the treatment of IBS, enteric-coated supplemental peppermint is most definitely preferred.
In fact, an enteric-coated peppermint oil capsule containing rosemary and thyme is extremely effective in the treatment of IBS. All three of these oils are classified as volatile oils, derivatives found in plants that impart taste and aroma. The combination of peppermint, thyme, and rosemary oils in enteric-coated capsules provides significant relief in IBS-related pain.
Q. Can clown’s mustard and other herbs be taken with enteric-coated peppermint oil?
A. Yes, peppermint oil capsules and clown’s mustard can be used together. However, depending on the symptoms, individuals with IBS may want to start with one supplement and then add the other if needed.
Q. How do consumers find these formulas?
A. Fortunately, herbal combinations containing clown’s mustard and enteric-coated peppermint oil capsules are both available at health food stores, natural product supermarkets, pharmacies, and from health professionals. Most knowledgeable sales personnel and health professionals can direct consumers to the most effective products.
Q. What should customers look for when purchasing peppermint oil?
A. As mentioned before, enteric coating of the peppermint oil is extremely important. The coating prevents the oil from being absorbed in the stomach. The enteric coated-capsule moves through the stomach to the small intestine and eventually to the colon, where it is released for maximum benefit.
Q. What is the dosage for peppermint oil?
A. The German Commission E approved peppermint oil for the treatment of irritable colon. In enteric-coated form, the Commission E recommends 0.6 ml per day. Enteric-coated peppermint capsules are available.
Q. Are there side effects or other contraindications?
A. Sometimes, the enteric-coated peppermint oil capsules may cause a transient burning sensation in the rectum when moving bowls. Reducing the dose will correct this.
Individuals who must refrain from alcohol should not take clown’s mustard in an herbal tincture, which may contain alcohol.
Q. What else can IBS patients do to feel better?
A. Food allergies or food intolerance may be associated with IBS. Dairy products and certain grains may trigger a painful episode of IBS. Determining those foods that initiate the problems and eliminating them from your diet can be very helpful.
Many people report their symptoms occur after a meal. Hyperactivity of the intestine of IBS is the response. Often, the strength of this response after a meal is in direct relation to the number of calories and he amount of fat in the meal. Reducing saturated fat, limiting calories, and increasing fiber intake may be helpful.
Stress also stimulates the intestinal hyperactivity. Relaxation training may reduce some IBS symptoms. Listening to therapeutic audiotapes, hypnosis, counseling, and biofeedback all have been shown to improve the healing response in persons with IBS.
IBS can be painful and frustrating, capable of causing much distress. While currently there is no cure for IBS, the symptoms can be managed. The pain, abdominal discomfort, and bowel problems of IBS all respond well to treatment with the use of key herbs, including clown’s mustard, and enteric-coated peppermint oil. These herbal combinations can be both effective and safe in treating IBS. Clown’s mustard and enteric-coated peppermint oil are both effective front-line natural alternatives for IBS treatment.
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Are there negative interactions with medicine?
February 27, 2007 09:25 AM
Author: Darrell Miller
Subject: Are there negative interactions with medicine?
No, there are no known negative interactions with any medication. However, you should always consult with your physician prior to altering prescription drug therapy.
Coenzyme Q10 and Cardiovascular Health.
December 13, 2005 11:34 AM
Author: Darrell Miller
Subject: Coenzyme Q10 and Cardiovascular Health.
CoQ10 is a vitamin-like compound that is produced naturally in the human body and is also found in most living organisms. It is also called ubiquinone, a combination of quinone, a type of coenzyme, and ubiquitous, meaning it exists everywhere in the human body. CoQ10 plays an important role in your body’s energy production and is an essential component of the mitochondria, where it helps to metabolize fats and carbohydrates and maintain cell membrane flexibility. CoQ10 is also involved in the production of several key enzymes that are used to create ATP, which is burned by your body for energy, and used in the energy transfer between mitochondria and cells. Without CoQ10, you would not be able to function!
CoQ10 is also an effective antioxidant that may beneficially affect the aging process. As we age, our body’s production of CoQ10 declines by as much as 80 percent. Because it is so important to energy production, and therefore life, researchers believe that this decline may be a factor in the effects of aging on the human body. Clinical trials on both animal and human subjects have revealed a marked decrease in CoQ10 levels in relation to a wide variety of diseases. As a free radical scavenger, CoQ10 inhibits lipid peroxidation – a normal aspect of the aging process that is implicated in certain agerelated diseases. Studies conducted in the last fifteen years suggest CoQ10 is important for maintaining healthy intracellular activity, and some researchers have compared its efficiency to that of vitamin E, one of the most effective of all dietary antioxidants. Research has shown that CoQ10, along with glutathione and selenium, works to regenerate or recycle vitamin E after it’s capacity to fight radicals has been diminished, thereby allowing vitamin E to remain active as an antioxidant for a longer period of time in your body.
CoQ10 was first discovered by Dr. Frederick Crane of the University of Wisconsin in 1957. One year later, Professor Karl Folkers and others at Merck Inc. identified and recorded CoQ10’s chemical structure, and were the first to produce it through fermentation. Intermittent research led to its use in Japan for cardiac insufficiencies during the 1960’s. Dr. Folkers championed more intensive research into CoQ10’s role in cardiovascular health in 1972, after he and an Italian scientist, Gian Paolo Littarru, discovered that persons with cardiac insufficiencies had very low levels of CoQ10, and supplementation increased CoQ10 levels and positively affected heart health. Soon afterwards, the Japanese developed a method that allowed pure CoQ10 to be produced in quantities large enough for significant clinical trials. During the 1980’s this method was perfected in Japan, and medical technology finally allowed scientists to measure CoQ10 levels in blood and tissues, leading to a surge in further research. It was during this time that a Swedish researcher, Lars Ernster, drew attention to CoQ10’s role as a free radical-scavenging antioxidant. Today a multitude of research supports CoQ10’s health benefits.
As a result of the overwhelmingly positive reports from studies conducted since CoQ10’s discovery, the Japanese were the first to approve widespread use of CoQ10, granting market approval for it in 1974. From 1974 to 1982, CoQ10 use in Japan grew rapidly until it was one of the most widely used products in the Japanese pharmaceutical industry. It is still widely used today, and has a long history of safe use. In “An Introduction To Coenzyme Q10” by Peter H. Langsjoen, M.D., F.A.C.C., he lists the substantial amount of scientific evidence that supports CoQ10’s benefits. “Internationally, there have been at least nine placebo controlled studies on the treatment of heart disease with CoQ10: two in Japan, two in the United States, two in Italy, two in Germany, and one in Sweden. All nine of these studies have confirmed the effectiveness of CoQ10 as well as it’s remarkable safety. There have now been eight international symposia on the biomedical and clinical aspects of CoQ10 (from 1976 through 1993). These eight symposia comprised over 3000 papers presented by approximately 200 different physicians and scientists from 18 countries.”
“The majority of the clinical studies concerned the treatment of heart disease and were remarkably consistent in their conclusions: that treatment with CoQ10 significantly improved heart muscle function while producing no adverse effects or drug interactions.” There are many CoQ10 supplements on the market today, and it can be difficult to choose the best brand and dosage. CoQ10 is a fat-soluble substance, which means it is more easily absorbed and used by your body in the presence of fat. CoQ10 supplements that include lecithin or another dietary fat will be more effective, and CoQ10 in a softgel form should be in an oil base, usually soybean oil. The dosage most commonly used in research is 30 mg, but higher doses are optimal and may be required to maintain optimal levels as we age. Always remember to consult your health practitioner before taking dietary supplements if you have current health problems or are taking prescription medication.
Now Foods continues to be a leading supplier of high-quality, low cost CoQ10 products. In 1999 and 2003 NOW Foods CoQ10 was voted the best-selling brand in health food stores nationwide, earning the Vity Award from Vitamin Retailer magazine. NOW carries eight different effective potencies of CoQ10, ranging from 30mg to 400mg, in lonzenges, softgels, and vegetable capsules. Many of our formulas are complexed with other synergistic nutrients like vitamin E, selenium, lecithin, and hawthorn for greater absorption and efficiency.
Butterbur Extract Fact Sheet
December 08, 2005 04:22 PM
Author: Darrell Miller
Subject: Butterbur Extract Fact Sheet
Butterbur Extract Fact Sheet Neil E. Levin, CCN, DANLA 8/1/05
LIKELY USERS: People wanting to support healthy blood flow to the brain and healthy neurological function 1-6,10 Those maintaining normal seasonal immune responses 7-10
KEY INGREDIENTS: 75 mg of Guaranteed Potency Butterbur Root (Petasites hybridus) Extract, min. 15 Sesquiterpenes as Petasines; 200 mg of Feverfew Leaf (Tanacetum parthenium) min. 0.4% Parthenolides
MAIN PRODUCT FEATURES: Butterbur (Petasites hybridus) is a native shrub of Europe, North America, and Asia that has been used by herbalists for centuries. Modern scientific studies have demonstrated that Butterbur supports healthy blood flow to the brain and healthy neurological function.1-6, 10 In addition, Butterbur may help to maintain balanced seasonal immune responses.7-10 In a synergistic base of guaranteed potency Feverfew leaf.11-26
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW Butterbur is free of harmful levels of Pyrrolizidine Alkaloids (PAs), the undesirable compounds naturally found in Butterbur, so it is safe to use regularly.
SERVING SIZE & HOW TO TAKE IT: Take one VCap one to three times per day, or as directed by your physician.
COMPLEMENTARY PRODUCTS: Magnesium, Ulcetrol, B-2, B-12, Fish Oil (EPA, DHA), SAM-e, Ginger, Ginkgo Biloba
SPECIFIC: Do not discontinue use abruptly; taper off use if discontinuing. Discontinue use at least 14 days before surgery or oral surgery. Use with caution if you have ragweed allergies or blood disorders and let your physician know that you plan to use it before you take it. May be contraindicated for pregnant women.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Diener HC, Rahlfs VW, Danesch U (2004) The First Placebo-Controlled Trial of a Special Butterbur Root Exract for the Preventio of Migraine: Reanalysis of Efficacy Criteria. Eur Neurol 51:89-97.
2. Lipton RB, Gobel H, Einhaupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventative treatment for migraine. Neurology 63:2240-2244.
3. Pothmann R, Danesch U (2005) Migraine Preventiuon in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 45:196-203.
4. Rapaport AM, Bigal ME (2004) Perventive migraine therapy: what is new. Neurol Sci 25:S177-S185.
5. Wu SN, Chen H, Lin YL (2003) The mechanism of inhibitory actions of S-petasin, a sequiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells. Planta Med 69(2):118-124.
6. Wang G-J, Wu X-C, Lin Y-L, Ren J, Shum AY-C, Wu Y-Y, Chen C-F (2002) Ca2+ channel blockin effect of iso-S-petasin in rat aoritic smooth muscle cells. Eur J Pharmacol 445(3):239-45.
7. Lee DKC, Carstairs IJ, Haggart K, Jackson CM, Currie GP, Lipworth BJ (2003) Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy 33:882-886.
8. Lee DKC, Haggart K, Robb FM, Lipworth BJ (2004) Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy 34:110-114.
9. Lee DKC, Gray RD, Robb FM, Fujihara S, Lipworth BJ (2004) A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy 34:646-649.
10. (No Author) (2001) Petasites hybridus (Butterbur). Alt Med Rev 6(2):207-209.
11. Hayes NA, et al. The Activity of Compounds Extracted from Feverfew on Histamine Release from Rat Mast Cells. J Pharm Pharmacol. Jun1987;39(6):466-70.
12. 2 Groenewegen WA, et al. A Comparison of the Effects of an Extract of Feverfew and Parthenolide, a Component of Feverfew, on Human Platelet Activity In-vitro. J Pharm Pharmacol. 1990;42(8):553-57.
13 Capasso F. The Effect of An Aqueous Extract of Tanacetum parthenium L. on Arachidonic Acid Metabolism by Rat Peritoneal Leucocytes. J Pharm Pharmacol. Jan1986;38(1):71-72.
14. 4 Bejar E. Parthenolide Inhibits the Contractile Responses of Rat Stomach Fundus to Fenfluramine and Dextroamphetamine but not Serotonin. J Ethnopharmacol. Jan1996;50(1):1-12.
15. 5 Prusinski A, Durko A, Niczyporuk-Turek A. [Feverfew as a Prophylactic Treatment of Migraine]. Neurol Neurochir Pol. 1999;33(Suppl 5):89-95.
16. 6 Barsby RW, et al. Feverfew Extracts and Parthenolide Irreversibly Inhibit Vascular Responses of the Rabbit Aorta. J Pharm Pharmacol. Sep1992;44(9):737-40.
17. 7 Pittler MH, Vogler BK, Ernst E. Feverfew for Preventing Migraine (Cochrane Review). Cochrane Database Syst Rev. 2000;(3):CD002286.
18. 8 Pattrick M, et al. Feverfew in Rheumatoid Arthritis: A Double-blind, Placebo Controlled Study. Ann Rheum Dis. 1989;48:547-49.
19. 9 Makheja AM, et al. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostaglandin Leukotri Med. 1982;8:653-60. 20. 12 Drug Identification Number Notification. Drugs Directorate, Therapeutic Products Division, Health Protection Branch, Health Canada . Ottawa , Canada
20. 12 Drug Identification Number Notification. Drugs Directorate, Therapeutic Products Division, Health Protection Branch, Health Canada. Ottawa, Canada.
21. 14 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press; 1996:119-21.
22. 15 PDR for Herbal Medicines, 2nd ed. Montvale , NJ: Medical Economics Company; 2000:307.
23. 16 Pribitkin ED. Herbal therapy: what every facial plastic surgeon must know. Arch Facial Plast Surg. Apr2001;3(2): 127-32.
24. 17 Schmidt RJ. Plant dermatitis. Compasitae. Clin Dermatol. Apr1986;4(2):46-61.
25. 18 Heck AM, et al. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Jul2000;57(13): 1221-7.
26. 19 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London : The Pharmaceutical Press; 1996:119-21.
Butterbur at Vitanet ®
TMG Fact Sheet
December 07, 2005 02:13 PM
Author: Darrell Miller
Subject: TMG Fact Sheet
TMG Fact Sheet Neil E. Levin, CCN, DANLA 03/07/05
LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups.
MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine.
TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals.
Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot.
ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid.
TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures.
DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably.
SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed.
COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement.
People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG.
This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. Review. PMID: 15321791
Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].
Benson R, Crowell B, Hill B, et al. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res 1993;18:325–30.
Chambers ST. Betaines: their significance for bacteria and the renal tract. Clin Sci 1995;88:25-7 [review].
Charlton CG, Crowell B Jr. Parkinson’s disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423–31.
Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61.
Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5.
Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93.
Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. Review. PMID: 15218538 Gahl WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis 1988;11:291-8.
Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. PMID: 14652361
Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203
Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002 Nov;76(5):961-7. PMID: 12399266
Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
van Guldener C, Janssen MJ, de Meer K, et al. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J Intern Med 1999;245:175-83.
Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50.
Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria—the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53.
Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985 Dec;34(12):1115-21. PMID: 3934499
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Barak AJ, Beckenhauer HC, Matti J, Tuma DJ. Dietary betaine promotes generation of hepatic S-adenosylmethioine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 1993;17:552-5.
Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329
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Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. Vet Hum Toxicol 1998;40:263-6.
Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488-99. PMID: 12730887
Kettunen H, Tiihonen K, Peuranen S, Saarinen MT, Remus JC. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69. PMID: 11691612
Kim SK, Kim YC, Kim YC. Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem Toxicol 1998;36:655-61.
McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses. 2000 Sep;55(3):189-94. PMID: 10985907
Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 1998;44:249-55.
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Semmler F. Treatment of liver diseases, especially of fatty liver with betaine citrate. Ther Ggw 1977;116:2113-24 [in German].
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Autism & Seizures:
Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.
Roach ES, Carlin L. N,N-dimethylglycine for epilepsy. N Engl J Med. 1982;307:1081-82.
Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6.
Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6.
Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 Apr;222(4):343-50. PMID: 2468082
Allibiotic CF Fact Sheet
December 07, 2005 01:37 PM
Author: Darrell Miller
Subject: Allibiotic CF Fact Sheet
Allibiotic CF Fact Sheet Neil E. Levin, CCN, DANLA 03/09/05
LIKELY USERS: People seeking support of the immune system and intestinal flora
KEY INGREDIENTS: Allicin (“AlliSure” patented, stabilized allicin from fresh garlic); Olive Leaf Extract (Olea Europaea with 18% minimum Oleuropein content); Elderberry extract, from fruit/berry, 60:1 concentrate (equivalent to 2,500 mg. of fresh berries of Sambucus nigra); Oil of Oregano (wild oregano from Origanum vulgare) ImmunEnhancer AG (trademarked Arabinogalactan from Larch Tree, Larix occidentalis)
MAIN PRODUCT FEATURES: AlliSure is the clinically tested, patented and stable form of allicin. Not allicin potential, but actual allicin. Allicin represents the immune supporting nutrients of raw garlic, and is chemically similar to penicillin, though with different physical properties. AlliSure shares garlic’s abilities to help maintain healthy cholesterol and blood pressure levels, and also has been shown to raise levels of a key T cell to enhance immune system function. Like raw garlic, AlliSure has antimicrobial properties linked to its ability to react with sulfur-containing metabolic enzymes. Allicin is also shown in studies to play a role in controlling blood sugar and abnormal cell growth.
Black Elderberries have strong antioxidant properties, containing flavonoids like anthocyanidins. They have been studied in relation to inhibition of viral replication and of minor inflammations.
Olive Leaf has been used as an antioxidant, cholesterol and blood viscosity regulator, and vasodilator. But its most important use has been as a way to help the body deal with undesirable organisms in the vital respiratory and intestinal areas.
Oil of Oregano (wild oregano, wild marjoram) contains carvacrol and thymol, which are responsible for much of its antimicrobial activities. It also has some anti-inflammatory effects.
Arabinogalactan from Larch tree bark (ImmunEnhancer AG) can help speed the immune system’s response to undesirable organisms and is often compared to Echinacea. It has also been shown to promote the growth of beneficial intestinal bacteria.
ADDITIONAL PRODUCT INFORMATION: Patented and trademarked ingredients enhance quality controls and have clinical research. Rosemary Oil provides antioxidant protection for the capsule contents. Enteric coating protects the capsule from stomach acid to deliver its contents past the stomach. This helps to assure full potency and reduces the possibility of the oils repeating.
SERVING SIZE & HOW TO TAKE IT: One softgel twice daily, preferably with meals. Try one before using the full dose.
COMPLEMENTARY PRODUCTS: Probiotics, Antioxidants, D-Flame
CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Discontinue use if any uncomfortable side effects occur. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001 Jul-Aug;18(4):189-93. (AlliSure was used in this study.)
Abramovitz D, Gavri S, Harats D, Levkovitz H, Mirelman D, Miron T, Eilat-Adar S, Rabinkov A, Wilchek M, Eldar M, Vered Z. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis. 1999 Oct;10(7):515-9. PMID: 10562920
Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother. 1997 Oct;41(10):2286-8. PMID: 9333064
Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol. 1996 Apr;13(4):273-7. PMID: 8739190
Chowdhury AK, Ahsan M, Islam SN, Ahmed ZU. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. Indian J Med Res. 1991 Jan;93:33-6.
Eilat S, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis. 1995 Dec;6(12):985-90. PMID: 8723021
Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Oron-Herman M, Rosenthal T. The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens. 2003 Dec;16(12):1053-6. PMID: 14643581
Feldberg RS, Chang SC, Kotik AN, Nadler M, Neuwirth Z, Sundstrom DC, Thompson NH. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrob Agents Chemother. 1988 Dec;32(12):1763-8.
Focke M, Feld A, Lichtenthaler K. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS Lett. 1990 Feb 12;261(1):106-8.
Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer. 2000;38(2):245-54. PMID: 11525603
Patya M, Zahalka MA, Vanichkin A, Rabinkov A, Miron T, Mirelman D, Wilchek M, Lander HM, Novogrodsky A. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol. 2004 Feb;16(2):275-81. PMID: 14734613
Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):144-153. PMID: 11118647
Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1998 Feb 2;1379(2):233-44. PMID: 9528659
Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004 Apr;111(4):391-9. PMID: 15056375
Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N. Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24. PMID: 15044429
Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med. 1985 Oct;(5):460-1. PMID: 3001801
Uchida Y, Takahashi T, Sato N. [The characteristics of the antibacterial activity of garlic (author's transl)] Jpn J Antibiot. 1975 Aug;28(4):638-42. PMID: 1099271
Yasuo Yamada and Keizô Azuma. Evaluation of the In Vitro Antifungal Activity of Allicin. Antimicrob Agents Chemother. 1977 April; 11(4): 743–749.
Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 423.
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Murkovic M, Abuja PM, Bergmann AR, et al. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study. Eur J Clin Nutr. Feb2004;58(2):244-9.
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 104–5.
Yesilada E. Inhibitory Effects of Turkish Folk Remedies on Inflammatory Cytokines: Interleukin-1Alpha, Interleukin-1Beta and Tumor Necrosis Factor Alpha. J Ethnopharmacol. Sept1997;58(1):59-73. Youdim KA, Martin A, Joseph JA. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radical Biol Med 2000;29:51–60.
Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Alt Compl Med 1995;1:361–9.
OLIVE LEAF EXTRACT:
American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.
Bennani-Kabchi N, et al. Effects of Olea europea var. oleaster leaves in hypercholesterolemic insulin-resistant sand rats. Therapie. Nov1999;54(6):717-23.
Bisignano G, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. Aug1999;51(8):971-4. Gonzalez M, et al. Hypoglycemic activity of olive leaf. Planta Medica. 1992;58:513-515. Visoli F, et al. Oleuropein protects low density lipoprotein from oxidation. Life Sciences. 1994;55:1965-71. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:557.
Petroni A, et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.Thromb Res. Apr1995;78(2):151-60. Pieroni A, et al. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie. Oct1996;51(10):765-8. Zarzuelo A, et al. Vasodilator effect of olive leaf. Planta Med. Oct1991;57(5):417-9. OREGANO OIL (OIL OF OREGANO, WILD OREGANO, WILD MARJORAM):
Dorman HJ, et al. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. Feb2000;88(2):308-16. Force M, et al. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. May2000;14(3):213-4.
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985–90.
Kelm MA, Nair MG, Strasburg GM. Antioxidant and Cyclooxygenase Inhibitory Phenolic Compounds from Ocimum sanctum Linn. Phytomedicine. Mar2000;7(1):7-13. Lamaison JL, et al. Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm Acta Helv. 1991;66(7):185-8.
Ponce MM, Navarro AI, Martinez GMN, et al. In vitro effect against Giardia of 14 plant extracts. Rev Invest Clin 1994;46:343–7 [in Spanish].
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Tantaoui EA, Beraoud L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ Pathol Toxicol Oncol 1994;13:67–72. ImmunEnhancer AG (Larch tree Arabinogalactan)
Corado J, et al. Impairment of Natural Killer (NK) Cytotoxic Activity in Hepatitis C Virus (HCV) Infection. Exp Immunol. 1997;109:451-457. Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53. PMID: 12725568
Egert D, et al. Studies on Antigen Specificity of Immunoreactive Arabinogalactan Proteins Extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58:163-165. Gonda R, et al. Arabinogalactan Core Structure and Immunological Activities of Ukonan C, An Acidic Polysaccharide from the Rhizome of Curcuma longa. Biol Pharm Bull. 1993;16:235-238. Hagmar B, et al. Arabinogalactan Blockade of Experimental Metastases to Liver by Murine Hepatoma. Invasion Metastasis. 1991;11:348-355. Kelly GS. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev. 1999 Apr;4(2):96-103. Review. PMID: 10231609
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Sytrinol can lower Cholesterol by 27% - 34%
September 20, 2005 09:56 AM
Author: Darrell Miller
Subject: Sytrinol can lower Cholesterol by 27% - 34%
Sytrinol – MultiPronged Heart Health
According to the American Heart Association, more than 60 million Americans suffer from on of more forms of cardiovascular imbalances. When we add in those individuals with blood cholesterol concerns, we see over 100 million Americans who may be in need of specific diet and lifestyle recommendations for achieving and maintaining heart health.
Aside from the generalized recommendations that we typically hear for heart health (lose weight, exercise more, and eat less fat and more fruits and vegetables) There are a number of potentially beneficial dietary supplements that may help to maintain cholesterol levels in the normal range. Among supplements there is a wide range of safety and efficacy between products—but a newer product called Sytrinol stands out for its clinical effectiveness.
Sytrinol is a patented blend of polymethoxylated flavones (from citrus) and tocotrienols (from palm fruit). One of the factors that sets Sytrinol apart from existing natural products for heart health is its multipronged approach to controlling multiple factors related to overall heart health—including control of cholesterol, cellular irritation, oxidation, triglycerides, and others.
While it is unarguable that cholesterol is an important contributor to overall heart health, it couldn’t be further from the truth that cholesterol is the “only” or even the most important factor when it comes to protecting your heart. Did you know that approximately HALF of all serious heart challenges each year are experienced by people with NORMAL cholesterol levels? If Cholesterol is not to blame, then what is?
In addition to total cholesterol levels (the “number” that you may know as 200 to 240 of other values in “mg/dl” units), we know how that LDL and HDL matter a lot (Low-density lipoprotein—the “bad” cholesterol, and High-density lipoprotein—the “good” cholesterol). We also know that some forms of the bad and LDL can be “Badder” than others—specifically those with lots of structural protein called “apolipoprotein B” (which tends to encourage LDL cholesterol to become embedded in your blood vessel linings—bad!). In addition to our total cholesterol, LDL, HDL, and the various apoproteins, we also need to know our triglyceride levels, our levels of cellular irritation, what our free radical load looks like, and what our antioxidant defenses are. Sytrinol addresses each of these important aspects of heart and health simultaneously.
The Sytrinol Solution
Polymethoxylated Flavones (PMFs) in Sytrinol are just what they sound like – flavonoid compounds with extra methoxy groups compared to “regular flavones. Like all flavonoids, the PMFs deliver potent antioxidant activity, but the PMF version is about three times more potent in its ability to address cholesterol levels (20% - 30% reduction in clinical Studies). The two primary PMFs are nobiletin and tangeretin.
In addition to the PMFs, Sytrinol contains palm tocotrienols—one of the most potent antioxidant nutrients known. An interesting effect of tocotrienols is a reduction in cholesterol synthesis in the liver—by a mechanism similar to (but safer than) the commonly utilized mechanism of inhibition of the HMG-CoA Reductase Enzyme.
Sytrinol is known to work via several unique mechanisms to reduce triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). First, by reducing DGAT activity (Diacylglycerol acetyl transferase) and increasing liver PPAR (Peroxisome porliferator-activated receptor)—Sytrinol can reduce overall synthesis of TG (DGAT inhibition). The overall effect is to reduce TG levels in the blood by two complementary mechanisms.
In terms of LDL effects, Sytrinol also reduces both Apolipoprotein B levels (ApoB—needed for the synthesis of LDL particles) and MTTP levels (microsomal triglyceride transfer protein-needed to transfer fat into the new LDL particles). By reducing levels of both these tructural LDL components, Sytrinol reduces overall LDL levels, and thus total cholesterol levels, in the blood.
The clinical results behind Sytrinol are impressive—showing a reduction in levels of total, LDL, and triglycerides by 27% - 34% within 4 weeks. In one of these studies, ApoB levels were reduced (suggesting reduced LDL) and ApoA1 levels were increased (suggesting increased HDL)—as would be expected based on the biochemistry of PMFs and tocotrienols.
Sytrinol is also wonderfully safe—and at the effective dose of 300mg daily, users will benefit from its multipronged effects. One aspect of Sytrinol safety that I especially like is the finding that, unlike some flavonoids like naringin from grapefruit, there are no known risks of drug interactions with the form of citrus derived PMFs found in Sytrinol (certain grapefruit flavonoids can interfere with liver enzymes needed to metabolize many prescription drugs).
Not since Red Yeast Rice was removed from the market by the FDA, have we had a truly effective, multimechanism solution for cholesterol control (and nearly total heart health). There are certainly other options for addressing heart health and cholesterol levels, but among the available choices, such as policosanol, guggulipid, niacin, and plant sterols, we’re looking at about half the cholesterol-lowering ability (10% - 15% in most cases) compared to Sytrinol. If youre in the “borderline” zone of cholesterol levels (about 240mg/dl and below), you should absolutely consider Sytrinol to keep your cholesterol levels under control.
Kurowska EM, manthey Ja. Hypolipidemic effects of absorption of citrus polymethoxylated flavones in hamsters with diet-included hypercholesterolemia. J Argic food chem.. 2004 may 19;52(10):2879-86.
Kurowska EM, manthey Ja, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, Tangeretin. Lipids 2004 feb;39(2):143-51.
Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL, Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human moncytes. J Nat Prod. 1999 mar;62(3)441-4.
Mora A, Paya M, rios JL, Alcaraz MJ. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Parmacol. 1990 Aug 15;40(4):797-7.
Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol exp. Ther. 2000 Apr;293(1):230-6.
By: Shawn M. Talbott, PH.D.
Disclaimer: The above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider. The information in this article has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Source Naturals - Scientific Formulation
August 20, 2005 11:42 AM
Author: Darrell Miller
Subject: Source Naturals - Scientific Formulation
“Formulation is an art—based on science, traditional approaches, and a thorough understanding of an issue. My prime responsibility is to design and create formulas that are comprehensive and effective. I strongly believe in supporting the whole person and in empowering people to take control of their health through nutrition and self-education.” –Linda Meltzer, C.N., Research Specialist
Formulation at Source Naturals begins with our highly trained research and product development staff. Our researchers conduct an exhaustive review of the scientific literature on each nutrient or botanical.
Their investigation covers traditional approaches, modern medical interventions, and current studies.
Dosage, delivery method, optimal ratios and combinations of ingredients, biochemical interactions of nutrients and herbs, the quality and form of raw materials—all are scrutinized in a quest for product efficacy. Members of our research, product development, quality control, regulatory affairs and manufacturing groups regularly attend quality circle meetings. At these meetings, team members contribute their particular expertise to resolve complex issues in the development of formulas, labels and literature.
Source Naturals researchers have all the scientific knowledge and tools of the supplement industry at their fingertips— but they also have something other companies may lack. Our expert formulators understand the need to address nutritional symptoms* at their root cause: body system imbalances. The ultimate expression of this quality-assured formulation method is our line of Bio-Aligned Formulas™. These products address nutritional symptoms* by supporting the multiple body systems involved.
Only by this holistic method of bringing alignment to your interdependent body systems can vibrant health be attained.
Source Naturals labels and literature explain the structure-function benefits of each product. Corroborated research backs these statements, from authoritative sources such as biochemistry texts, respected journals, herbal pharmacopoeia and homeopathic Materia Medica.
Our labeling and literature are reviewed by attorneys who specialize in FDA law. This ensures that claims are accurate and appropriate according to the Dietary Supplement Health and Education Act (DSHEA).
Strontium Bone Maker 60 VC - Strengthen Bones
July 27, 2005 12:06 PM
Author: Darrell Miller
Subject: Strontium Bone Maker 60 VC - Strengthen Bones
Helps maintain strong, healthy bones.*
In Vitro and Animal Studies
Strontium is a bone-seeking mineral incorporated by ionic substitution for calcium onto the crystal surface of bone.2 In the test-tube (in vitro), strontium inhibits the activity of osteoclasts, bone cells that break down bone, or “resorb” bone as part of the normal bone remodeling process.3 The effect of strontium, in the form of strontium ranelate (a salt of strontium and ranelic acid), was studied in monkeys over a six-month period. Strontium altered the remodeling of bone in the monkeys, resulting in decreased bone resorption with a concomitant maintenance of bone formation. A trend toward increased volume of osteoid, the organic matrix of bone, was observed, although this was not associated with defects in bone mineralization.4 In another animal study, monkeys fed strontium at high doses for six weeks showed a marked increase in bone strontium content. No harmful effects on bone mineral chemistry or structure occurred.5 At low doses, strontium has been shown to increase the number of bone forming sites in thighbones of adult rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.6 Strontium was shown to reverse bone loss induced by estrogen deficiency in rats.7
Human clinical trials have examined the effect of strontium on bone in postmenopausal women. In the dose-ranging (Phase 2) PREVOS trial, women in early menopause were administered strontium ranelate or a placebo for two years. Strontium ranelate was given at daily doses of 125 mg, 500 mg or 1 gram. (Total weight of compound; strontium plus ranelic acid). Compared to women in the placebo group, who lost bone, women on strontium at the 1 gram dose showed statistically significant increases in bone mineral density (BMD) of the hip, thigh and lumbar spine. Biochemical markers of bone formation, such as serum alkaline phosphatase, increased. No effect on markers of bone resorption was observed, leading to the conclusion that strontium ranelate, at the 1 gram daily dose, increased bone formation without decreasing bone resorption proportionally. It was concluded that 1 gram per day is the minimum effective daily dose of strontium ranelate in these women.8
In another Phase 2 trial (STRATOS trial), 353 postmenopausal women with osteoporosis, who had experienced at least one spinal fracture, took strontium ranelate for two years at daily doses of 500 mg, 1 gram or 2 grams. Women on the 2-gram dose showed a significantly greater increase in lumbar spine BMD than those on placebo. The number of subjects who had new spinal deformities was significantly reduced.9 As in the PREVOS trial, serum levels of alkaline phosphatase, a marker of bone formation, increased, while markers of bone resorption (breakdown) decreased. The overall conclusion is that the minimum effective daily dose of strontium ranelate (whole compound) is 1 gram in early postmenopausal non-osteoporotic women and 2 grams in postmenopausal women with osteoporosis.10
Phase 3 efficacy studies on strontium ranelate have been conducted on 1649 subjects in 12 countries. These studies began with an open-run (non-controlled study period in which subjects took calcium and vitamin D supplements to normalize their blood levels of these nutrients.11 Following this, two parallel groups were administered 2 grams daily of strontium ranelate or placebo for 3-years. The subjects continued to take calcium and vitamin D during the study. In subjects on strontium ranelate, BMD increased in the lumbar vertebrae by 14.4 percent and in the thighbone by 8.3 percent. The number and risk of vertebral fractures decreased.12
Suggested Use: Take two capsules daily. Calcium intake must also be adequate. Do not take this product with calcium supplements.
Strontium ranelate was well-tolerated in the trials discussed above. The incidence of adverse events in subjects on strontium ranelate was statistically equivalent to the placebo groups, and no negative effects on hematology and other biochemical parameters have been observed.
In view of the fact that subjects on the strontium trials also took calcium, and in some cases vitamin D, to maintain normal blood levels of these nutrients, it is important to ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.13 In rats with chronic kidney failure, strontium has been shown to cause osteomalacia, a condition in which bone is softened due to lack of mineral content. For this reason, people on kidney dialysis should not use strontium supplements.14
1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 1952; 13:59 -66.
2. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone 2001;28(4):446-53.
3. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 2002; 450:11-17.
4. Buehler J, Chappuis P, Saffar JL, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis) Bone 2001;29(2):176-79.
5. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996 Sep;11(9):1302-11.
6. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18(3):253-9.
7. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 1993;8(5):607-15.
8. Reginster JY, Deroisy R, Dougados M, et al. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose ranging, placebo-controlled PREVOS trial. Osteoporosis Int 2002; 13:925-31.
9. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis––a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87(5):2060-66.
10. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporosis Int 2003; 14(Suppl 3):S56-S65.
11. Meunier PJ, Reginster JY. Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis. Osteoporosis Int 2003;14(Suppl 3):S66-76.
12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350(5):459-68. 13. Grynpas MD, Marie PJ. Effects of strontium on bone quality and quantity in rats. Bone 1990;11:313-19.
14. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes osteomalacia in chronic renal failure in rats. Kidney Int 1998;54:448-56.
Fight Hay Fever - Help Your Sinus...
July 11, 2005 09:15 PM
Author: Darrell Miller
Subject: Fight Hay Fever - Help Your Sinus...
The National Institute of Health’s branch of Allergy and Infectious Diseases re p o rt that 40 to 50 million Americans suffer from allergies in one form or another. Many experience food allergies that a re treated somewhat diff e rently from hay fever allergies. Hay fever comes from airborne allergens, generally from pollen or pollutants.
The symptoms of allergy occur when an immune system is overactive. The immune system often recognizes something as foreign and treats it as foreign by attacking it, when in fact it really isn’t a substance the body should be concern e d with. This over-activity of the immune system leads to the release of substances including histamine that cause the symptoms of hay fever.
The most common symptoms include a runny nose and itching eyes and scratchy throat. Sometimes, an allergy will precede a sinus infection by causing swelling in the nasal membranes preventing fluids f rom exiting the sinus passages. An infection then ensues. However, most people who feel pressure over their sinuses, never develop an infection and so can be adequately treated with the supplements mentioned here. Many people experience a tickle or a shallow cough that comes from the throat rather than the lungs. They may also experience a change in emotions, becoming quite irritable or moody.
These airborne allergies can often be g rouped by season. Those people sensitive to tree pollens usually have more severe allergies in the springtime. Those sensitive to grasses are often worse in mid-summer. Those allergic to weeds have their symptoms peak in the fall. There are some unfortunate people who have allergies all summer long who may be allergic to a few plants in each group. Those who have symptoms of allerg i e s all winter long probably are allergic to molds and mildew or household animals and dust mites. On occasion, it takes a real detective to determine from where the allergies come.
There are several methods used to diagnose a cause of an allergy. In a scratch test, drops of an allergen are put on small scratches on the arm or the back. Are action is considered positive if swelling or redness occur around the scratch. A blood sample can also be used to meas ure antibody response to certain allergens. It is often helpful to determine the allergen which cause the hayfever to reduce the symptoms. There are also practitioners who use kinesiology or electronic devices to determine the cause of allergies.
The most common treatment of allergies is with antihistamines. Their side effects include drowsiness and drying of the mucous membranes of the nose and mouth. Many of the newer prescription antihistamines don’t cause drying but often have serious drug interactions and the consumer must be very careful in combining the prescription antihistamines with antifungal drugs, and blood thinning as well as asthma medication. There are some natural products that can be taken to decrease allergy symptoms. They are often equally effective without the side effects of antihistamines.
One of the more popular is quercetin. Quercetin is a bioflavonoid found in red apples, red onions, brussels sprouts, kale, peas, bell peppers, pears and asparagus. It is also found in bee pollen and propolis, two plant materials found in the beehive. It is possible to consume a fair amount of quercetin through your diet. If you have allergies, however, diet is often not enough and you may need a supplement to get enough quercetin to ontrol your symptoms. It appears quercetin decreases allergic symptoms by stopping the release of histamine. If you start taking quercetin and other nutritional supplements I will mention below before an allergy attack, they are likely to be more effective. However, don’t let that discourage you from taking them even after the symptoms have started. A common dose is 300mg to 600mg per day.
Bromelain is a nutrient often extracted f rom pineapple. Found in many digestive formulas, it is an enzyme that helps absorption. If it is found in a combination formula, chances are, it is there to help with the absorption of the other nutrients such as quercetin. Bromelain also has an anti-inflammatory effect. When someone develops allergy symptoms, part of the reason is due to the inflammatory response to substances such as histamine that are released as the allergy takes hold. This causes inflammation in the tissues which then manifests with redness and swelling.
Vitamin C is useful in many conditions including hay fever. Higher doses are often required in the treatment of allergies: 2,000mg is beneficial and you can take up to 4,000mg or more during acute symptoms. It also stabilizes capillaries, reducing the swelling in the throat, nasal passages and around the eyes. If you are taking a multi-vitamin or a combination product that contains Vitamin C, I still recommend additional supplementation.
NETTLE (URTICA DIOICA)
Stinging nettle is probably a plant many a re familiar with, especially if it has come into contact with your skin, but it also has an historical use in the treatment of allergy. In fact, in double blind studies it was shown to decrease the symptoms of allergy, specifically runny nose.
EPHEDRA (MA HUANG)
The active component of the ephedra herb is ephedrine, an alkaloid. It is used in OTC asthma medication. As a natural herb, ephedra in small doses can be v e ry useful in decreasing the symptoms of colds, asthma, cough and in this case, hay fever. It is in many Chinese and American formulas that I use and I feel v e ry comfortable using 100mg to 200mg of ephedra that contain small doses of 2.5mg to 8mg of ephedra alkaloids per day. I feel comfortable using dosages of up to 15mg of ephedra alkaloids .
Feverfew is another herb with a variety of uses. You will find it in headache formulas, in fever reducing formulas, and many hay fever formulas. Like bromelain, it has an anti-inflammatory effect and reduces the swelling that occurs during a hay fever attack.
Homeopathic formulas can also be useful to reduce hay fever. There is no re ason why the herbs I’ve mentioned cannot be combined with homeopathic formulas. You may want to take them at separate times of the day.
So, if you suffer from hay fever, don’t give up. You can use these nutrients singly or in combination. You can take a formula that contains all of them and then add to that additional vitamin C for instance, or additional nettle. It may require trial and error to find the right amounts in combination that will work for you.
Echinacea - Choosing The Ideal Immune Support
June 30, 2005 09:27 AM
Author: Darrell Miller
Subject: Echinacea - Choosing The Ideal Immune Support
Echinacea By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt Echinacea, pronounced ek-i-NAY-see-a, is one herb that has become a “household” name in the 1990’s. Many refer to it as “Purple Cone Flower” because of its large purple daisy petals, which contain a hard and spiny center cone. These spines probably give the plant its name, since sea animals with spines are called “echinoderms”. Echinacea is indigenous to the U.S., and can be found both growing wild in many areas as well as in cultivated gardens. There are actually nine different species of the plant; two are most popular as remedies: Echinacea angustifolia and Echinacea purpurea. Echinacea has a long history of use by Native Americans, who have utilized the herb for a wide variety of treatments ranging from stings, poisoning, toothaches and swollen glands to colds and sore throats. It has also been touted as an ideal natural remedy for snake bites. In particular, the benefit of Echinacea as a treatment for snake bites brought national attention to the herb in the last half of the 1800’s. Dr. H.F.C. Meyer of Pawnee City, Nebraska first tried to interest Eclectic Physicians (doctors who used natural medicines) to use Echinacea as an herbal remedy for snake bites by volunteering to be bitten by a rattlesnake to prove its effectiveness. Although his dramatic offer was rejected, his enthusiasm and concerted efforts led to renewed interest and investigative studies on Echinacea, resulting in the herb’s emergence as one of the most popular natural plant therapies by the turn of the century.
Extensive studies on Echinacea’s medicinal properties continue to mirror the earlier usages of the herb as experienced by indigenous people. In fact, Echinacea is part of the official materia medica listed in the German Commission E. Monographs, a universally recognized publication reputed to be the official information authority on herbal medicines. The Commission lists a number of medicinal applications for Echinacea as an ideal treatment for such conditions as colds, chronic infections of the respiratory tract and lower urinary tract ailments, as well as topically for chronic ulcerations and slow healing wounds.
Echinacea has been shown to be a potent immune system stimulant. Nature’s Answer® offers an outstanding Echinacea fluid herbal extract formula in a unique blend that contains both Echinacea angustifolia root and Echinacea purpurea whole plant. Fluid extracts that feature both whole plant and root parts in the formula insure that the highest levels of the whole herb’s active constituents are maintained. A further advantage to this kind of supplement lies in its delivery system– liquids are faster to absorb and easier to assimilate by the body than tablets or capsules. Nature’s Answer®’s Echinacea formulas are available in either alcohol-free or organic alcohol forms. In addition, the alcohol-free supplements are also offered in a tasty grape or tangy orange flavor.
Two popular blends featuring Echinacea with other supportive herbs are Immune Boost™ and Re-Zist™. Immune Boost™ combines Echinacea with Wild Indigo and Maitake Mushroom. Re-Zist™ contains Echinacea, Goldenseal, Wild Indigo, Cayenne and Myrrh for potent support.
Echinacea is also recognized for its ability to enhance the resistance of cells to viruses, especially when used after cells have been exposed to colds and flus. As a preventative, formulas such as Nature’s Answer®’s Echinacea/Goldenseal (alcohol-free, organic alcohol) are ideal. This is an excellent supplement for soothing sore throats and helping to shrink swollen glands. An added benefit to the formula is the presence to berberine, the active ingredient in Goldenseal, which provides further wellness enhancement.
Many studies have focused on Echinacea’s possible use for ailments such as psoriasis and early rheumatoid arthritis. The herb also acts as an overall anti-inflammatory tonic. Nature’s Answer®’s Blood Support™ (alcohol-free) combines Echinacea with Dandelion, Licorice and other herbs for an anti-inflammatory effect. Allertone™ (alcohol-free) blends Echinacea with Mullein Leaf to help support the respiratory and sinus areas.
Most herbal practitioners suggest using Echinacea for short-term periods. There has been evidence to suggest that the herb loses its effectiveness when used over longer periods of time. Also, in the case of autoimmune illnesses, some people believe Echinacea may OVER-stimulate the immune system, although there is no solid research to back this contention. Echinacea is probably most effective if used in frequent doses for 5-7 days at the early onset of symptoms. It may also serve as a preventative during periods after known exposure or during extra stress, taking it two to three times a day every other or every third day. The German Commission E lists no known drug interactions or side effects with Echinacea. It is indeed one of the safest and most effective herbs for natural immune support today.
Echinacea seems well suited to life in the 90’s with all the stresses upon our immune systems. Its importance and effectiveness as an immune stimulant is as true today as it was in 1927 when Dr. Liebstein stated:
“Nature has probably destined Echinacea to be used for remedial purposes only, as a sustainer of vitality, an organizer of the defensive powers of the system, to such an extent as to be justly crowned the greatest immunizing agent in the entire vegetable kingdom....” written in 1927 by Dr. A. M. Liebstein (Foster, 1991)
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.
June 25, 2005 08:13 PM
Author: Darrell Miller
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Hyattsville, Maryland: National Center for Health Statistics; 1994. 4 Center for Science in the Public Interest and McDonald’s Nutrition and You—A guide to Healthy Eating at McDonald’s: McDonald’s Corp,1991. 5 Bray GA. Appetite Control in Adults. In: Fernstrom JD, Miller GD eds. Appetite and Body Weight Regulation. Boca Raton: CRC Press, 1994:1-92. 6 Michnovicz JJ. How to Reduce Your Risk of Breast Cancer. New York: Warner Book Inc. 1994:54. 7 Carcinogens and Anticarcinogens in the Human Diet. National Research Council Report, National Academy of Sciences, 15 Feb. 1996. 8 Van Tallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979:32: 2723-33. 9 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:273. 10 Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16A-hydroxyestrone to estradiol in human breast concer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1988:85;7831-5. 11 Colditz GA. Epidemiology of breast cancer. Findings from the nurses’ health study. Cancer1993;714:1480-9. 12 Hennen WJ. Breast Cancer Risk Reduction. The effects of supplementation with dietary indoles. Unpublished report 1992. 13 Deslypere BJ. Obesity and cancer. Metabolism 1995;44(93):24-7. 14 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:281. 15 Whittemore AS, Kolonel LN, John M. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 1995;87(9):629-31. 16 Key T. Risk factors for prostate cancer. Cancer Survivor 1995;23:63- 77. 17 Kondo Y, Homma Y, Aso Y, Kakizoe T. Promotional effects of twogeneration exposure to a high-fat diet on prostate carcinogenisis in ACI/Seg mice. Cancer Res 1994;54(23):6129-32. 18 Wang Y, Corr JG, Taler HT, Tao Y, Fair WR, Heston WD. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst. 1995;87(19):1456-62. 19 Nixon DW. Cancer prevention clinical trials. In-Vivo 1994;8(5):713-6. 20 Key T. Micronutrients and cancer aetiology: the epidmiological evidence. Proceed Nutr Soc 1994;53(3):605-14. 21 Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Reviews of Infectious Diseases 1990;12(Suppl 2):S252-61. 22 Shrapnel WS, Calvert GD, Nestel PJ, Truswell AS. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Australia. 1995;156(Suppl):S9-S16. 23 Ellis JL, Campos-Outcalt D. Cardiovascular disease risk factors in native Americans: a literature review. Am. J. Preventive Med 1994;10(5):295-307. 24 DiBianco R. The changing syndrome of heart failure: an annotated review as we approach the 21st century. J. Hypertension 1994; 12(4 Suppl):S73- S87. 25 Van Itallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979;32(suppl):2723-33. 26 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure and glucose metabolism in mildly hyper-cholesterolemic men. Am J Clin Nutr 1990;52(4):661-6. 27 Story JA. Dietary fiber and lipid metabolism. In: Spiller GA, Kay RM. eds. Medical Aspects of Dietary Fiber. Penun Medical; New York, 1980, p.138. 28 Stein PP, Black HR. The role of diet in the genesis and treatment of hypertension. Med. Clin. North America. 1993;77(4):831-47. 29 Olin JW. Antihypertensive treatment in patients with peripheral vascular disease. Cleve. Clin. J. Medicine. 1994;61(5):337-44. 30 Tinker LF. Diabetes Mellitus—a priority health care issue for women. J. Am. Dietetic Association. 1994;94(9):976-85. 31 Gaspard UJ, Gottal JM, van den Brule FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas. 1995;21(3):71-8. 32 Coordt MC, Ruhe RC, McDonald RB. Aging and insulin secretion. Proc. Soc. Exp. Biology and Medicine. 1995;209(3):213-22. 33 Felber JP. 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RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available
June 24, 2005 05:34 PM
Author: Darrell Miller
Subject: RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available
The average American’s life expectancy has risen dramatically over the last 100 years. Ideally those extra years will be quality ones. High levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help. Free radicals cause oxidative stress, which is a major cause of accelerated aging. Source Naturals presents the science of RENEWAL ANTIOXIDANTS. This Bio-Aligned Formula™ is a significant advancement over other products currently available. No other formula provides the broad range of high potency, established and newly discovered water and fat-soluble antioxidants that RENEWAL ANTIOXIDANTS delivers.
Bio-Aligned Antioxidant Support
RENEWAL ANTIOXIDANTS™ supports multiple body systems with a balanced spectrum of plantioxidants™ (botanical extracts with unparalleled ability to combat free radicals), vitamins and specialty nutrients that have powerful antioxidant properties. Research suggests dietary antioxidants help balance and modulate free radical activity and help maintain structure and function of important components of cells such as lipids, proteins, and DNA.
Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to cells and tissues. Free radicals are unpaired electrons that can damage cells and compromise the function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of lipid and water soluble antioxidants to minimize this negative effect. No other antioxidant formula follows the science better than RENEWAL ANTIOXIDANTS to defend against the widest spectrum of destructive free radicals, including peroxyl, hydroxyl, and superoxide radicals, and singlet oxygen.
Antioxidants neutralize destructive free radicals and support cardiovascular health by halting the oxidation of cholesterol. Cholesterol is only harmful to us if it becomes oxidized. Oxidized cholesterol is an unstable molecule that damages arteries. RENEWAL ANTIOXIDANTS contains hearthealthy antioxidants including gamma E and tocotrienols, which are major lipid-soluble antioxidants that help maintain the integrity of cell membranes by preventing lipid oxidation. The formula includes hawthorn berry and grape seed, CoQ10, lycopene and other powerful antioxidants for heart support.
Nourishing the Brain
Antioxidants are critical for brain and nerve tissue because the brain is mostly composed of fats, which are very sensitive to free radical damage. Research has shown that stress can directly set in motion mechanisms that promote aging, which affects brain and nerve tissue. Ginkgo has been shown to increase memory performance and learning capacity as well as improve blood flow. It is also a free radical scavenger. RENEWAL ANTIOXIDANTS also contains DMAE, bilberry, CoQ10, grape seed, lipoic acid, vitamin B-2 and lutein for broad spectrum support.
Powerful antioxidants help minimize stress damage to liver cells and tissues, thereby supporting detoxification. N-acetyl cysteine is a powerful antioxidant. It is also a precursor to glutathione, a critical antioxidant and detoxifying substance produced in the liver. Silymarin is known for supporting the regeneration of the liver. Since the liver is prone to fat incursion, which makes it vulnerable to oxidative damage, the following fat soluble antioxidants provide critical protection: CoQ10, lipoic acid, ascorbyl palmitate, and gamma E.
The immune system is unlike other body systems in that it is not a group of physical structures but a system of complex interactions involving many different organs. White blood cells generate enormous amounts of destructive free radicals in order to kill invading organisms. Vitamin C, a free radical scavenger, is concentrated in these white blood cells at a much higher level than in surrounding fluid. This extends their life and effectiveness by providing them with a built in defense mechanism against their own free radicals. RENEWAL ANTIOXIDANTS provides water and fat-soluble vitamin C (ascorbyl palmitate and ascorbic acid) along with vitamin A, beta carotene, CoQ10, lipoic acid, quercetin, selenium, gamma vitamin E, tocotrienols, zinc and turmeric, for added immune defense.
Skin & Connective Tissue
Skin is rich in lipids, proteins, and DNA, which are extremely sensitive to oxidation. Age-related changes due to oxidation, loss of elastic fibers and thickening of collagen fibers, cause skin to become fragile and less supple. A broad array of antioxidants protects skin and helps maintain its structure and tone. These include beta carotene, vitamin C, vitamin E, grape seed, zinc, amla (Phylanthus emblica), quercetin, DMAE, manganese and myricetin. Amla is a very effective herbal tonic. It is rich in polyphenols and vitamin C.
Eye tissue is particularly prone to the effect of free radicals. Vision involves light being focused through the lens onto the retina. The macula, or center of the retina, receives the most light. However, sunlight is a powerful free radical generator. Lutein, a potent, fatsoluble antioxidant concentrated in the macula, helps maintain the integrity of the macula and the blood vessels that supply the macular region. The eye also has aqueous tissue that is better protected by water-soluble antioxidants, such as bilberry and grape seed. RENEWAL ANTIOXIDANTS provides these ingredients, along with lycopene, zeaxanthin, lipoic acid, vitamin A, beta carotene and ascorbyl palmitate to support healthy eyes.
Mitochondria, the tiny energy factories within the cells, are the major source of free radicals produced by our own bodies. These components of cells produce ATP (the energy molecule) and provide energy for all cellular activity; therefore, antioxidants are crucial to keep the levels of oxidants they produce in check. RENEWAL ANTIOXIDANTS provides the antioxidant power of green tea, lipoic acid, zinc, vitamin B-2, CoQ10 and Mega H-, a source of electron rich hydrogen ions. Coenzyme Q10 is fat-soluble and its primary functions include activity as an antioxidant and as a cofactor in many metabolic pathways, particularly in the production of ATP in oxidative respiration.
DNA, the blueprint for all molecules in the body, can be altered or damaged by oxidation. Protecting DNA is important for optimal health of all cells and tissues. According to invitro research, certain compounds, such as curcumin (from turmeric) and quercetin, can directly protect against strand-breakage and base oxidation. RENEWAL ANTIOXIDANTS contains these ingredients along with rosemary, pomegranate, raspberry, blueberry leaf, and carnosine. In in-vitro studies, L-carnosine reduced glycation, a process in which DNA and protein are damaged by glucose.
Living Longer, Living Better Strategies for Wellness
• Eat Well: Include plenty of fresh fruits and vegetables. Antioxidants in foods exist as vitamins C and E, beta-carotene, selenium and as flavonoids (tea), lycopene (tomatoes) and anthocyanins (berries). The highest concentrations of antioxidants are found in deeply colored fruits and vegetables such as dark leafy greens, artichokes, blueberries, cranberries, plums, blackberries and cherries. Spicing up food with cinnamon, turmeric, cloves and oregano can also boost antioxidant power. • Stay Active: Exercise benefits the heart, helps regulate weight and slows the aging process by increasing the amount of oxygen available to body tissues. • Reduce Stress: Deep breathing improves your blood’s oxygenation and circulation. • Stop Smoking: Smoking depletes the body of vitamins C and E along with other antioxidants.
Taking personal responsibility for your health and exploring safe alternatives to support prevention is the basis for the wellness revolution. Your health food outlet is leading the way with education and quality products to help you take control of your well-being. Source Naturals is pleased to partner with these outlets to bring you the cutting edge nutritional science of RENEWAL ANTIOXIDANTS. Antioxidant protection is a fundamental part of the holistic healing system. Make this profound formula the cornerstone of your anti-aging program today.
Clement, M., Bourre, J. Graded dietary levels of RRR-y-tocopherol induce a marked increase in the concentrations of a- and y-tocopherol in nervous tissues, heart, liver, and muscle of vitamin E-deficient rats. Biochimica et Biophysica Acta 1334 (1991) 173-181. Borgstrom, L. Pharmacokinetics of N-acetylcysteine in Man. Eur J Clin Pharmacol (1986) 31:217-222. Hipkiss, A.R., et al. Carnosine, a protective, antiaging peptide? Int J Biochem & Cell Biol. 30, May 1998, 863-868.
Heart and Blood Vessels Resveratrol, Gamma E, Tocotrienols, Vit C, Hawthorn Berry, Grapeseed, Myricetin, CoQ10, Ginkgo, Beta & Alpha Carotene, Zeaxanthin, Lycopene, Lutein, Astazanthin, Lipoic acid, Green Tea, Bilberry, Ginger, Turmeric, Blueberry Leaf
Brain and Nervous System DMAE, Ginkgo, Carnosine, Bilberry, CoQ10, Grapeseed, Lipoic Acid, Vit B-2, Lutein
Liver Lipoic Acid, N-Acetyl Cysteine, Vit A, B-2,and C, Beta Carotene, Silymarin, CoQ10, Selenium, Zinc, Gamma E, Tocotrienols, Turmeric, Ginger Glutathione, Wheat Sprouts
Immune System Vit A & C, Beta Carotene, CoQ10, Lipoic Acid, Quercetin, Selenium, Gamma E, Tocotrienols, Zinc, Turmeric
Skin & Connective Tissue Beta Carotene, Vit B-2, C & E, Grapeseed, Lutein, Lycopene, Zeaxanthin, Zinc, Amla, Quercetin, Manganese, DMAE
Eyes and Vision Lutein, Beta Carotene, Vit A & C, Bilberry, Lycopene, Zeaxanthin, Lipoic Acid, Quercetin, Gamma E, N-Acetyl Cysteine, Selenium, Zinc
Energy Production and Metabolism Green Tea, Ginger, Mega H-, Ginkgo, CoQ10, Lipoic Acid, Zinc, Vit B-2, Carnosine DNA Protection Turmeric, Quercetin, Rosemary, Grapeseed , Resveratrol, Lycopene, Lutein, Tocotrienols, GliSODin®, Carnosine, Zinc, Manganese, Amla, Pomegranate, Raspberry leaf, Blueberry leaf
GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....
June 21, 2005 05:25 PM
Author: Darrell Miller
Subject: GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....
GPC (GlyceroPhosphoCholine): Versatile Life Support Nutrient
Parris Kidd, Ph.D.
GPC - Marked Benefits to the Brain GPC Supports Normal Brain Function GPC Works Through Multiple Mechanisms Dosing, Safety, Tolerability, Compatibility GPC: Nutrient for All Ages
GPC or GlyceroPhosphoCholine (pronounced gli-sero-fos-fo-ko-lean) is a nutrient with many different roles in human health. It reaches extremely high concentrations within our cells, and its abundance in mother's milk suggests it is crucial to life processes. Clinically, GPC has been most intensively researched for its brain benefits. Biologically, it has great importance for the skeletal "voluntary" muscles, the autonomic nervous system, kidneys, liver, and reproductive organs. GPC goes beyond being a brain nutrient; it is a nutrient for vitality and long life.
Marked Benefits to the Brain
As a dietary supplement, GPC's brain benefits are unique. It boosts mental performance in healthy young people, as shown by three double-blind trials. In trials on middle aged subjects, GPC improved several physiologic measures of mental performance: reaction time, visual evoked potential, and EEG delta slow waves. In the elderly, GPC improves mental performance and provides noticeable revitalisation. In 11 human trials with 1,799 patients, memory, attention, and other cognitive measures improved. So did mood (including irritability and emotional lability), and patients often developed renewed interest in relatives and friends. GPC was well tolerated, and generated no bad drug interactions. A large trial on elderly subjects with memory challenges published in 2003 concluded GPC had significant benefits for these individuals.
GPC Supports Normal Brain Function
Circulatory deprivation or surgery can challenge healthy brain function. GPC can speed recovery and support improved quality of life. In four trials with GPC on 2,804 subjects who experienced difficulties under these circumstances, up to 95% showed good or excellent improvement. GPC consistently improved space-time orientation, degree of consciousness, language, motor capacity, and overall quality of life. The investigators concluded GPC offered marked benefits, with an excellent benefit-to-risk profile. Up to half of patients who survive bypass surgery experience problems with memory and other mental performance. A double-blind trial conducted with bypass survivors for six months determined that the GPC group had no remaining memory deterioration, while the placebo group failed to improve.
GPC Works Through Multiple Mechanisms
GPC supports human health through a variety of mechanisms:
1. It helps keep choline and acetylcholine available to the tissues. Choline is an essential nutrient and GPC appears to be the body's main choline reservoir. GPC in mother's milk represents the baby's main source of dietary choline. Acetylcholine (ACh) is an important substance employed extensively throughout the body. ACh is a major brain transmitter; the motor nerves use ACh to drive the skeletal ("voluntary") muscles; the autonomic nervous system uses it to pace all the organs. ACh is also central to mental and physical endurance, and mind-body coordination.
2. GPC is a major cell-level protectant, not as another antioxidant but in pivotal roles of osmotic pressure regulator and metabolic antitoxin. GPC for osmotic regulation can reach very high concentrations in the kidney, bladder, liver, brain, and other organs. As metabolic protectant, GPC shields proteins against urea buildup.
3. GPC is a major reservoir for cell membrane omega-3 phospholipids. These substances are the major building blocks for cell membranes. Enzymes couple GPC with the omega-3 fatty acid DHA, to make the phospholipid PC-DHA. This makes membranes especially fluid, enabling membrane proteins to perform with better efficiency. GPC produces PC-DHA in the skeletal muscles, wherein fluidity is essential for contraction. Muscles that function abnormally can show GPC deficiency.
4. GPC contributes to both male and female in reproduction. As spermatozoa mature, GPC is used to make PC-DHA that makes their membranes fluid to enable motility. With men, the lower their semen GPC the greater the likelihood of poor sperm motility and with it, infertility. Once semen is inserted into the female, an enzyme in uterine secretions breaks down the semen's GPC into substances that energize the sperm to achieve fertilization.
Dosing, Safety, Tolerability, Compatibility
Oral intake of GPC in the clinical trials was usually 1,200 milligrams (mg) per day, taken early in the day on an empty stomach. A reasonable dietary supplementation regimen is 1200 mg/day, taken in divided doses (AM and PM) between meals for 15-30 days, and thereafter 600 mg/day for maintenance. Symptomatic subjects can take 1200 mg/day until adequate improvement is achieved. Young, healthy subjects may experience benefit from daily intakes as low as 300 milligrams. GPC is very safe, being compatible with vitamins and nutrients and with pharmaceuticals. In clinical trial comparisons, GPC's benefits surpassed the nutrients acetylcarnitine and CDP-choline.
GPC: Nutrient for All Ages
GPC is unmatched for its support of active living and healthy aging. In some 23 clinical trials GPC improved mental performance in all functional categories. GPC can revitalize the aging brain, facilitating growth hormone (GH) release and boosting nerve growth factor actions. GPC's ample presence in human mother's milk suggests it could be conditionally essential. By supporting mental integrity, mind-body integration, the autonomic system, and the body's other organs, GPC enhances the active lifestyle. GPC is remarkable nutritional support for optimal health at any age.
Parris M. Kidd, PhD is a cell biologist trained at the University of California, Berkeley and San Francisco. Since entering the dietary supplement field in 1983, he has published many in-depth reviews of integrative medicine in the journal Alternative Medicine Reviews, and is science columnist for totalhealth magazine. Dr. Kidd is internationally recognized for his accomplishments in dietary supplement product development, documentation and quality control.
Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.
7-Keto - The Key to Healthy Aging
June 21, 2005 05:05 PM
Author: Darrell Miller
Subject: 7-Keto - The Key to Healthy Aging
7-Keto " The Key to Healthy Aging
The global population is aging at an alarming rate and causing an explosion in health care costs, insurance premiums, cosmetic surgery and more. In the U.S. alone, more than one million baby boomers are expected to live to 100 years of age or older. This increased life expectancy presents a whole new set of health concerns that the medical community has not had time to address, since there is a greater need to care for age-related health problems in this ever-growing elderly population.1
Aging and the Decline in Vital Nutrients
We all grow old at the same rate but people age at different rates. Aging is a process of gradual changes that occur to varying degrees in each of us. Interestingly, the aging process is composed of different components and interactions, some of which can be impacted. One such component is the declining level of essential biological compounds, which causes our bodily functions to slow and become dysfunctional. Our organs don?t work efficiently, our immune system becomes lazy, we lack energy, our metabolism drops and we gain weight easily.1 7-oxo DHEA (7-Keto™) is a naturally occurring compound that declines with age.2 Replacing this key metabolite helps promote a healthy immune system and maintains resting metabolic rate at levels that accelerate weight loss during standard weight reduction programs.
Aging and a Healthy Immune System
Numerous changes occur in the immune system with advancing age, probably contributing to decreased immune responsiveness. Although all segments of the immune system are affected, investigators have most consistently identified declines in cellular or T-cell mediated immune function in the elderly. The decline in T-cell immune function is generally associated with an increased susceptibility to foreign organisms. For example, individuals with age-related declines in cellular immunity have an impaired response to vaccinations, making them more susceptible to health imbalances even though they have had their shots. In a clinical study presented at the Federation of American Societies for Experimental Biology meeting in April 2004, the effect of 7-Keto on elderly immune function was evaluated. Healthy elderly adults were given 7-Keto orally twice daily over a period of one month. The study revealed that 7-Keto augmented several key T-cell mediated immune function parameters compared to placebo administration.4
Age-Related Weight Gain
Age-related weight gain and obesity are approaching epidemic proportions in our country.5 Weight gain is a disorder of energy balance involving energy intake and/or expenditure. Low energy expenditure, a drop in resting metabolic rate (RMR), is a challenge during most weight loss attempts due to age, calorie restriction, lack of physical activity or a combination of factors. RMR represents 60% of total daily energy expenditure. Maintaining a higher RMR as we age and during weight reduction programs helps us achieve and maintain a normal weight. Furthermore, compounds with the thermogenic potential to achieve even minimal increases in daily energy expenditure of 2-3% may have clinical relevance in preventing the decline in RMR with calorie restricted diets or weight loss, and in decreasing the risk of regaining weight. 7-Keto, a non-stimulant thermogenic compound, has been shown to significantly increase energy expenditure in humans.6 A recently completed clinical study, also presented at the Federation of American Societies for Experimental Biology 2004 meeting, revealed that administration of 7-Keto to overweight adults in conjunction with a calorie restricted diet effectively reversed the decline in RMR normally associated with dieting. Obese participants following a calorie-restricted diet demonstrated a 5.4% increase in daily RMR with 7-Keto.7 The magnitude of the increase in RMR by 7-Keto is clinically relevant, and represents a promising agent for enhancing thermogenesis and weight loss in obese individuals on calorie-restricted diets. Additionally, 7-Keto has been shown in two confirmatory published clinical studies to result in three times more weight loss compared to diet and exercise alone. It has a favorable side effect profile and is easy and convenient to take.8,9 Our life expectancies will likely be longer than those of our parents, and our quality of life during those years will depend on how well we take care of our bodies now. Undoubtedly, the science of aging will give rise to new and exciting technologies to help us age more gracefully and healthfully. Maintenance of healthy immune function is keenly needed for improved quality of life in the elderly. Dietary manipulation and supplementation has been identified as a method of immune system renewal, and supplements such as 7-Keto may play an important future role as immune system modulators. Moreover, the addition of 7-Keto to any weight loss program will offer vital support of energy expenditure and help with the attainment of a manageable and healthy weight into our older years.
1. 1995 White House Conference on Aging, ?Executive Summary: The Road to an Aging Policy for the 21st Century," February 1996: 17-18. 2. Marenich LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-Keto-Dehydroepiandrosterone in Healthy Men of Different Ages. Prob Endokrinol. 1979; 25(4): 28-31. 3. Ginaldi L, De Martinis M, D?Ostilio A, Marini L, Loreto MF, Quaglino D. Immunological Changes in the Elderly. Aging 1999; 11(5): 281-286. 4. Zenk JL, Kuskowski MA. The Use of 3-acetyl-7-oxo-dehydroepiandrosterone for Augmenting Immune Response in the Elderly, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 5. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and Trends in Obesity Among US Adults. 1999-2000. JAMA 2002;288:1723-1727. 6. Astrup A. Thermogenic Drugs as a Strategy for Treatment of Obesity. Endocrine 2000;13(2):207-212. 7. Zenk JL, Leikam SA, Kassen LJ, Kuskowski MA. A Prospective, Randomized, Double Blind Study to Evaluate the Effect of HUM5007 and 7-oxo DHEA on Resting Metabolic Rate in Overweight Adult Men and Women on a Calorie Restricted Diet, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 8. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. A Randomized, Double-Blind, Placebo Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Overweight Adults. Current Therapeutic Research 2000;61: 435-442. 9. Zenk JL, Helmer TR, Kassen LJ, Kuslowski MA. The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial. Current Therapeutic Research 2002; 63:263-272.
John L. Zenk, M.D., is Chief Medical and Scientific Officer for Humanetics Corporation and President and Medical Director of Minnesota Applied Research Center, both located in Eden Prairie, MN. He has spoken nationally and internationally on the subjects of integrating conventional and complementary medicine, anti-aging technologies, evaluating the effectiveness of alternative medicine, and dietary supplement research and development. He is author of the book Living Longer in the Boomer Age, and co-author of the book Age Wise and is a frequent contributor to national media. He has served as Principal Investigator for 15 controlled clinical studies, three of which were recently published in national peer-reviewed journals, and has presented abstracts at the 11th World Congress for Food Science and Technology and the Federation of American Societies for Experimental Biology.