Search Term: " Johns "
41 matching the search criteria.
Broccoli is one of the best detoxifying foods you'll ever find
February 20, 2019 01:17 PM
Author: Darrell Miller
Subject: Broccoli is one of the best detoxifying foods you'll ever find
Broccoli can really help your body’s ability to expel harmful toxins that you ingest or breathe in According to recent research, post-menopausal women who ate lots of cruciferous vegetables like broccoli showed a substantially lower risk of breast cancer, perhaps because broccoli improved their livers’ ability to detoxify their bodies. Likewise, a 12-week Johns Hopkins University study of almost 300 people in a heavily polluted part of rural China found that broccoli made their bodies much more efficient at excreting dangerous compounds like benzene and acrolein.
- One major study found that post-menopausal women who ate lots of broccoli and other cruciferous vegetables had a lower chance of breast cancer.
- A 12 week Johns Hopkins University study in a heavily polluted region of China found that broccoli improved excretion of harmful chemicals like benzene and acrolein.
- Broccoli can also promote better cardiac health, regulate your blood sugar and improve your immune system.
"These detoxifying benefits of broccoli can be attributed to the presence of phytonutrients called glucoraphanin, gluconasturtiian, and glucobrassicin."
Read more: https://www.naturalnews.com/2019-02-12-broccoli-is-one-of-the-best-detoxifying-foods.html
Scientists find GARLIC may treat lingering Lyme disease
January 28, 2019 08:10 AM
Author: Darrell Miller
Subject: Scientists find GARLIC may treat lingering Lyme disease
Garlic is one of those things that has a lot of health benefits. People underestimate diet and the massive effect that it can have on someone's body and piece of mind. These scientists are constantly doing studies that indicate that certain foods can be considered natural remedies. They are being proven to help people with certain diseases and the truth of the matter is that garlic is one of the main substances that is getting good reviews.
- Doctors from around the world are constantly looking at natural methods that can treat disease.
- Some people are much more prone to diseases or sickness based on their lifestyle and diet.
- It is really important for people to understand that the in take of certain foods can really help out your health.
"Known as persistent Lyme infection, it can last for months or even years, but now scientists from Johns Hopkins Bloomberg School of Public Health have found a natural solution that could finally put it to rest."
Read more: https://www.naturalnews.com/2018-12-08-scientists-find-garlic-treat-lingering-lyme-disease.html
St. John’s wort: A scientific review of its remarkable antibacterial and antioxidant properties
February 07, 2018 03:59 PM
Author: Darrell Miller
Subject: St. John’s wort: A scientific review of its remarkable antibacterial and antioxidant properties
St. John’s wort A scientific of this remarkable antibacterial and antioxidant properties study was from African but how some bacteria affect some crops that man nee for consumption and this is the bacteria strains which cause mastitis[ this happens when breast tissue is infected.], and also create problems for the mammary glands in terms of inflammation. Overall, researchers found out the H. perforatum extract contained significant antibacterial properties, which could have potential pharmacological uses — particularly in plant-based medicine.
- St. John's wort is a timeless herbal remedy that must be tried. It is best known for its antioxidant property that can be used.
- The plant does have an ability to counter cell mutation in the body. That will open the door to further research to be undertaken.
- A simple scientific review has been issued for St. John's wort. The remedy has an incredible array of antibacterial and antioxidant properties.
"While it exhibited antioxidant property, the research team posited that the plant’s ability to counter cell mutation opens the door to further research."
Read more: https://www.naturalnews.com/2018-02-05-st-johns-wort-a-scientific-review-of-the-antibacterial-and-antioxidant-properties.html
Air pollution may directly cause those year-round runny noses, according to a mouse study Johns ...
April 27, 2017 10:59 AM
Author: Darrell Miller
Subject: Air pollution may directly cause those year-round runny noses, according to a mouse study Johns ...
Are you one of those who always seems to have a runny nose? There are kids who go around like this a lot as well. You may be wondering what causes it. You probably think it's a cold or some sort of sinus infection that needs medications but you could be wrong about. This can also be caused by air pollution according to recent studies. Air pollution causes many problems and this is just another one.
Read more: Air pollution may directly cause those year-round runny noses, according to a mouse study Johns ...
Is the Mediterranean diet good for kids, too?
February 05, 2017 02:59 PM
Author: Darrell Miller
Subject: Is the Mediterranean diet good for kids, too?
Putting kids on a diet can be dangerous for them because kids have certain needs. They are still growing and need the proper fuel to do that. This talks about this and about the Mediterranean diet in particular. Before putting kids on any type of diet ask a doctor and do your own research so you don't hurt them.
- The easy-to-follow Mediterranean diet involves eating mostly vegetables, fruits, legumes, unrefined grains, olive oil and fish.
- Though the diet also includes skim or low-fat dairy products, the American Academy of Pediatrics recommends that children consume whole milk until age 2, Johnson said.
- Nuts are also included in the Mediterranean diet, but the academy considers whole nuts to be a high-risk food for choking and recommends caution for children under age 4, Johnson said. And, though the Mediterranean diet includes a modest amount of wine, alcohol is illegal to consume until age 21 in the United States.
"The easy-to-follow Mediterranean diet involves eating mostly vegetables, fruits, legumes, unrefined grains, olive oil and fish."
What Makes St Johns Wort Good For Depression And Anxiety?
September 18, 2012 09:18 PM
Author: Darrell Miller
Subject: What Makes St Johns Wort Good For Depression And Anxiety?
St Johns wort
St Johns wort is a particular plant species. Firstly, in ancient Greek the medicinal uses of St Johns wort are recognized. It is an herb with yellow flowers. It contains active ingredients like flavonoids, anthrancenes, volatile oil and sugar alcohol which are used for medicinal purpose. St Johns wort binomial name Hypericum perforatum is also considered as wild plant, herb and weed. The other common names for this plant are Amber Touch-and-heel, goat weed, Klamath weed, Rosin rose and Tipton weed. As it is an herb its leaves and flowers are used for medicinal purpose.
What is St Johns wort?
St Johns wort is considered as a medicinal plant. It has yellow flowers which are used for medical purposes in various parts of the world. It is an herbal remedy to treat depression. This medicinal plant is also used for migraine, headache, muscle pain, chronic fatigue syndrome. It is also used for cancer and HIV/AIDS. St Johns is known as natural herbal remedy for mild to moderate depression. This highly valuable contains a chemical known as hypericin which effects against depression. This chemical act as mediatator in the nervous system which control the mood.
Does St Johns worth help depression? Depression has now become a common problem in humans now days. Due to the side effects of antidepressant medications, people are frequently moving towards natural remedies. St John wort is a complete health booster for the entire nervous system. It is recommended as a useful herbal remedy. It is scientifically proven that this particular plant is effective for mild to moderate depression. It has been used to treat mental disorders. St John wort is commonly used for depression and the conditions which are responsible depression such as anxiety, tiredness and sleep disorders. In most of the countries it is widely prescribed for depression. Wort is beneficial to people with mild depression but it is less effective on major depression.
St Johns wort medicinal properties:This medicinal plant is a powerful medicine.It is effective and well tolerated by the patients.You can feel yourself improving within the first week of usage of St John wort.As it is well tolerated by the patients, you can see fast results with fewer side effects.It decreases anxiety related to depression.It includes medicinal properties like antibacterial, anti inflammatory, antiviral, antidepressant and pain relieving.Traditionally it has been used to cure burns, headache, wounds, etc.
Though this is a powerful and remarkable medicine for treating mild to moderate depression, but still there is a question in the mind of health experts regarding major depression? In accordance with this, medicinal wort is less effective for the people who are taking other medications. St John wort is not effective on severe depression as discussed earlier. St John wort causes drug interaction so it might not be the right choice for the people who take other medication. You cannot ignore St Johns Wort, as it is a natural remedy for treatment of depression in spite of having few side effects.
Herbs For Depression: Alternative Solutions To Improve Your Mood
February 17, 2012 07:29 AM
Author: Darrell Miller
Subject: Herbs For Depression: Alternative Solutions To Improve Your Mood
What Herbs Can Help With Depression?
Depression - Introduction:
Depression is brain system disorders that can make many people weaken from functioning normally during episodic events. Some types of depression actually paralyze people and prevent them from leading a normal life.
In addition, it is important for individuals who suffer from depression to realize, that they do not have to hide this condition and think that they suffer alone. In fact, many people have some form of depressive disorder. Something must be done is to take action to reduce their depression treatment.
Depression - Herbs That Can Help Reduce:
Depression and anxiety are very common in the modern world, and there is no single drug offers an effective cure. However, there are many herbal remedies that can help you reduce depression:
1. St John's Wort (Hypericum perforatum).
St Johns Wortis a eternalcompoundwith littleyellow flowers that originally came from Europe, but also widely used intoAmerican. It is used extensively by European physicians to reducedepression. Two compounds, hypericin and hyperforin, give St. John's Wort potencyto keepmood and fight depression. St. John's Wort also contains flavonoids and proanthoclanidin substances that can affect the peace and balance to the nervous system.
Valerian is the most popular herbs to relieve nervous tension. Sedative effect was first recognized in the seventeenth century, and since then enjoyed a long history of safe use effectively. Research believe that valerian binds to GABA receptors, which produces lower levels of anxiety. This does not completely eliminate anxiety, just change the way that the brain and your body reacts physiologically and give peace to the nervous system.
3. Kava kava.
Kava kava is a plant found in the Pacific Islands. The roots and bark are usually used as a slurry and then combined with cold water to drink. Due to the active compounds in Kava kava, a chemical known as kavalactone, destroyed by high temperatures, use cold or warm water is very important in its preparation. And studies have suggested a correlation between active ingredients and enhanced mood. To be specific, Kava Kava is estimated to have a relaxing impactand reduce fatigue in the human brain.
4. Ginkgo Biloba.
Ginkgo Biloba is the oldest tree used by China to treat various diseases. In the 1700's it has been introduced in Europe. Ginkgo Biloba is mainly composed of active components such as terpene lactones and flavnonoids, which gives a positive effect on mental well-being. With capabilities that are known to increase blood circulation to the brain, this herb has also decreasethe amount of free radicals in the body and brain, so it appears relaxation that can reduce stress or depression.
5. Lavender Oils.
Lavender is a very popular herbal aroma is mainly due to growing importance as a beautiful and essential oils. The smell of lavender oil can stimulate the nerves that send signals to the brain limbic system, which spur the peace and comfort to the physiological function of human emotional. Lavender has been believed by experts to help relieve anxiety, tension, stress and fear that are part of depression.
6. Lemon Balm.
Lemon Balm serves to inhibit the production of thyroid hormones and can help treat primary or secondary brain diseases and to provide a stimulant for the antioxidant that gives relief to your brain space. Some modern studies have found that lemon balm is useful for promoting sleep quality and reduce the effects of depression tranquility.
Chamomile is a very popular herb in Europe and has been widely used for centuries agoas a treatment for some diseases, such as sleep disorders, stress, anxiety, and depression. Other active compositions including flavonoids and matricinid which gives a feeling of relaxation and regulate the nervous system. Now it has proven to be one of the safest herbs on the market to relieve stress.
Although the use of herbs for depression is widely spread, overall there is definitely reaction for the benefits of herbs for reduce depression disorders. Apparent when compared with normally drugs for depression that usually can not serve as the first choice of treatment options. However, when other treatments have failed more established, might have to be used.
Herbs For Depression
December 13, 2010 12:34 PM
Author: Darrell Miller
Subject: Herbs For Depression
Fight Depression with Natural Herbs
Before discussing treating depression with natural herbs we should first consider depression itself: what is it and what causes people to become depressed? Psychiatrists and psychologists will suggest a number of definitions although most experts agree that there are two forms of depression.
Causes of Depression
Exogenous depression comes about as a result of external factors such as bereavement, heavy debt, job loss, etc, while endogenous depression comes from within and is believed to be due to biochemical problems, including food allergies, hormonal changes, thyroid problems, nutritional deficiencies, particularly Vitamin B deficiency, and addictions. There are many other reasons for people becoming depressed, some of which can be established by the particular symptoms of the individual.
In many cases of depression the external factors are often easier to treat than those due to internal factors. Many exogenous causes of depression such as bereavement are alleviated through time, while causes such as job loss and debt can be resolved once the cause has been rectified: thus, if the patient is no longer in debt or is re-employed, the depression tends to disappear with the cause.
Symptoms of Depression
Depression is not diagnosed from a single symptom, but from a number of symptoms that can point to a person being clinically depressed and requiring treatment. Among the symptoms of depression are:
Prolonged periods of sadness or despair
Feelings of pessimism for the future
Feeling generally tired and lethargic
Overeating with resultant weight gain or under-eating with resultant weight loss
Either insomnia or hypersomnia
Disinterest in family or work
Feeling of guilt, worthlessness and low self-esteem
Inability to concentrate
Hyperactivity or general inactivity
Forms of Depression
Many normal people can suffer one or two of the above systems, and would not be diagnosed as depressed because of it. We can all get mood swings, feel a bit worthless now and again or be unable to concentrate or focus at times, but that does not mean we are clinically depressed.
Depression would not be diagnosed in a patient with just one of these symptoms but five or more likely would be. In fact, the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders deem the patient suffering clinical depression if displaying 5 or more of the bottom 8 symptoms above for a month or more. This is believed to be the case with around 17 million Americans so it is a significant problem.
Manic depression is otherwise known as bipolar disorder, where patients have large mood swings from high and extreme hyperactivity and excitability to very low deeply depressive moods and is a clinical condition generally treated using drugs.
Treatment of Depression With Natural Herbs
The usual treatments are drugs that often have undesirable side effects; so many people are trying natural remedies instead. There are a number of herbs that can be used to treat depression, one of the most familiar being St. John's Wort. However, there are others, and here is a synopsis of each.
St. John's Wort
St. John's wort (hypericum perforatum) is likely the best known herbal treatment for depression. In fact, in Germany it is prescribed by doctors to children and adolescents for the treatment of mild depression and is available over the counter in many countries.
However, it can also be used in cases of severe depression, and a report in the Cochrane Database Review[8(4)] by K. Linde, M.M. Berner and L. Kriston in 2008 stated that of 29 separate tests carried out on a total of over 5,000 patients, the conclusion was that St. John's wort extracts were at least as good in treating severe depression with 5 times lower side-effects as tricyclic antidepressants and twice lower than the new selective serotonin reuptake inhibitors (SSRI).
It should be stated, however, that one trial on 340 subjects indicated no improvement over a placebo. However, the anti-depressive drug sertraline (Zoloft) was also shown to be no better than the placebo in this test, so some doubts must lie regarding its accuracy. Of all the herbal treatments, St. John's wort has had most testing carried out and it seems to be effective in treating mild to severe depression although not all experts are yet agreed.
Kava Kava Root
Kava kava can be used to treat depression and anxiety, largely due its content of kavalactones that are believed to increase the amount of a number of neurotransmitters in the blood, including the feel-good neurotransmitter serotonin. Kava kava root is mildly intoxicating, having much the same effect as alcohol, and can also reduce the symptoms of depression and anxiety.
However, it is doubtful if its effects are permanent and so it may be less of a depression cure as a short-medium term treatment. Its effects are also variable on different people, some describing it as making them feel relaxed and 'dreamy', while others find it therapeutic and making them feel better in themselves.
Kava kava should not be taken without your doctor knowing about because there have been concerns about its effect on the liver if taken in excess. A European-wide ban was lifted about two years ago after testing found the risks of taking it to be very low. It has been used for centuries as an intoxicating drink on islands such as Fiji.
Passion flower has been used for centuries to treat anxiety, stress and depression, its active ingredients believed to be maltol and ethylmaltol that help to increase the level of gamma-aminobutyric acid (GABA) in the brain. GABA is one of the brain's key neurotransmitters and has been described by some as the brain's own 'Valium' supply.
Through the intervention of GABA, passion flower extract helps in reducing anxiety levels and makes you feel a lot calmer. If you suffer forms of depression that make you hyper or excitable, passion flower will help to reduce this and also helps to cure insomnia. It is a component of many natural sleeping pills.
These are just three natural substances that can be used to treat depression. However, you must inform your doctor or physician if you decide to take them since they may interfere with or change the effect of any antidepressant drug you are currently taking.
Call today for natural remedies for depression
April 08, 2010 04:31 PM
Author: Darrell Miller
Subject: Agave Nectar
Comments by Craig Gerbore, CEO of Madhava:
Reading through the attack articles and blogs that have surfaced recently one could think that using agave is bad for one's health. These claims are utterly false and misleading. They are extreme views drawn from extreme examples and applied way out of context. They are propagandizing and clearly designed to frighten, not educate. All of the fears and concerns associated with the overconsumption of sugars and calories in general have been unfairly cast on agave.
What is a "healthy" sweetener? One that you use moderately and sensibly.
Health concerns related to fructose and caloric sweeteners are all dependant on the overconsumption of them. All foods have calories and it is the overall consumption of calories that lead to obesity and related issues, not any one food source.
Agave's caloric value is comparable to the other sweeteners in the category. Due to its greater sweetness though, less agave is used compared to the others, so agave actually can reduce caloric consumption per serving. This is due to a higher fructose content. The higher content does not mean higher consumption though, due to the smaller portion used. But, it is not the single serving that matters, it is the number of servings which lead to the overconsumption issues which may result in health concerns.
As a reference point, 9-10 teaspoon servings of agave would be the approximate caloric equivalent of one 16 oz soft drink. With this perspective, is agave really being overconsumed as a choice of sweetener for home use?
Every single health issue which the attackers have tried to associate with agave is really the result of a caloric overconsumption issue. There are no documented issues with normal, moderate consumption of agave or sweeteners in general as part of our everyday diet. For reasons unknown, some have attempted to isolate agave from the real world and real world conditions with the goal of inhibiting agave's use. They play on people's fears, reference false information and fail to address health issues in any meaningful way.
The purpose of this article is to debunk the controversial misinformation surrounding agave. All information debunking the myths and misinformation is based on current science and facts. It is our goal to provide you with useful information so that you can make your personal nutritional choices in a well-informed, science-based manner.
The Agave Controversy: Exposing the fraudulent article by Rami Nagel
By Dr. Susan Kleiner, PhD, RD, FACN, CNS, FISSN
And Craig Gerbore, CEO Madhava
The controversy about agave syrup was manufactured by the publication of a single article on the internet, which has been reproduced and adapted for virtually every other article produced on the internet and other media venues. That article, written by Rami Nagel and published on Naturalnews.com, was highly biased and full of inaccuracies, half-truths and misinformation about agave. Since the Naturalnews.com article has been the sole source of nearly all other popular articles in public media, we want to set the record straight with science-based, reliable information to offer a more balanced resource to those interested in learning more about agave syrup. Who is the author, Rami Nagel?
According to the description on the Naturalnews.com website, Rami Nagel is a "citizen journalist". This means that Mr. Nagel is self-employed, and not employed as an in-house journalist by the website. He wrote and published the article without any editorial or content oversight, and the editor of the website, Mike Adams, makes it clear that the article was not checked for incorrect or inaccurate information or facts. The introduction to the article, written by Mr. Adams, states that readers had written to comment that Mr. Nagel's resources were biased with conflicts of interest due to their financial interests in competing sweeteners, such as brown rice syrup. So even the website editor himself states that the article is not fact-checked, and it is biased and unbalanced.
Who is Russ Bianchi?
The sole resource interviewed for the article is Russ Bianchi, identified by the author as Managing Director and CEO of Adept Solutions, Inc. Mr. Bianchi has clear conflict of interest ties to the sweetener industry. We have documentation of the fact that Mr Bianchi had plans to market a product named Replace. It was to be touted as a low calorie alternative sweetener composed of natural and artificial ingredients! Mr Bianchi was prevented from marketing this sweetener as the result of a lawsuit against him by the owner of the formula.
Mr Bianchi is quoted by Nagel extensively and exclusively. Many, if not all, of his statements are blatantly false or misrepresentations of fact. He is clearly propagandizing against agave nectar.
Was anyone else interviewed for this article?
Yes. Craig Gerbore, president and owner of Madhava Agave Syrup, was extensively interviewed by the author but no parts of that interview were included in the article.
It is important to note that neither Mr Nagel or Mr Bianchi have not made themselves available for questions on their statements since the articles appearance. They remain out of sight and have entirely avoided the controversy their statements created.
What is agave nectar?
The opening line of this paragraph in the article by Mr. Nagel states:
"The principal constituent of the agave is starch, such as what is found in corn or rice."
This is absolutely false. There is no starch in agave. The source of carbohydrate in agave syrup is inulin, a polysaccharide made up primarily of strings of fructose units. Starch is a polysaccharide made up of strings of glucose molecules. They are significantly different, and this difference is why agave syrup is naturally sweet.
The very basis of the argument presented by Mr. Nagel is false.
The agave plant is a succulent, similar to a cactus. The agave sweetener comes from both the Salmiana agave plant and the agave Tequilana (Blue Agave) which are both organically farmed in Mexico and certified organic by USDA approved certifiers. As the salmiana plant grows it produces a stalk called the "quiote" and when this is removed, a natural liquid called "aquamiel". The liquid is collected from the plant, while Blue agave pinons are harvested and shredded to remove the similar juice. Either can be naturally processed thermally or by enzymes into agave nectar.
The juice of the plant is not naturally sweet. The string of connected fructose units that makes up the major proportion of inulin does not have a sweet taste, but when the fructose units are separated (the process is called hydrolysis) by the addition of an enzyme, similar to digestion, or thermally for most blue agave, the syrup becomes quite sweet. That is the entire processing chain for agave nectar. There are no additives, other ingredients or chemicals in Madhava agave nectar. It is absolutely pure and organic and GMO free.
? Mr. Nagel claims that agave syrup is a "refined corn fructose" similar to high fructose corn syrup. This is absolutely false. There is no relationship between agave syrup and high fructose corn syrup in any way, including the source of the product, or the manufacturing process.
? Mr. Nagel refers to a "confidential FDA letter" from Mr. Martin Stutsman, claiming that agave is fraudulently labeled. We contacted Mr. Stutsman at the United States Food and Drug Administration, and his response made it clear that there was never a "confidential FDA letter". He did publish a public letter referenced in an FDA document as "FDA letter from Martin Stutsman to Dr. Eric
Wilhelmsen (Wilhelmsen Consulting), May 8, 2000", regarding evaporated cane juice, a topic wholly unrelated to agave syrup.
? He continued in his response to us that the paragraph in Mr. Nagel's article inaccurately reflected the substance of his comments in the document.
This link will take you to the original document in which the letter was referenced (reference #2):
In fact, Mr. Nagel fabricated the entire story of the letter. Mr. Stutsman is a lawyer, not a doctor. The quotes were completely taken out of context from the document, and the quotes never referred to agave syrup at any time. Nagel goes on to further misrepresent Mr. Stutsman's intent in the published document by weaving in other inaccurate information that is thoroughly unrelated to the original document. Mr Bianchi's subsequent statements on labeling issues are false and without merit.
Mr. Nagel is clearly caught red-handed. He has misrepresented the words of a government official, lied about the facts, and twisted the information to achieve his own agenda. This strategy is repeated throughout the article.
? Mr. Nagel continues his deceptive writing by referring to a quote by the late Dr. Varro Tyler in his book, The Honest Herbal. The first line of the paragraph is a direct quote from the book. Nothing else in that paragraph remotely resembles anything else found in Dr. Tyler's book. Mr. Nagel is trying to claim that agave syrup contains large quantities of saponins, and that they can be harmful to health. Here is the debunking of that paragraph:
1. Dr. Tyler does not include the variety of agave plant used for agave syrup.
2. The entire discussion is about the use of the sword-shaped leaves and the stem. Agave syrup is produced from the natural liquid in the plant. The saponins are isolated from the leaves of the plant.
3. There is no documented evidence to suggest agave syrup contains worrisome levels of saponins and the entire rest of the discussion about health dangers is fabricated and false.
People are going to continue to consume sweet food and drink. There are only three categories of choice to sweeten food. Those are artificial sweeteners, stevia, or caloric sweeteners from natural sources, sugars.
Most people will not choose artificial. Many will not choose stevia. That only leaves the category of sugars. In this group, agave is a good choice due to its organic quality, ease of
use, neutral flavor, low glycemic index and the fact that less is used to equal the sweetness of the others in the category.
The sweeteners in this category are composed of three primary sugars used to sweeten foods: glucose, fructose and sucrose. These sugars belong to a class of compounds known as carbohydrates. "Saccharide" is a term that denotes sugar, or substances derived from sugar. Monosaccharides are simple or single sugars; disaccharides are derived from two joined monosaccharides and when they are hydrolyzed, or separated, they yield two molecules of simple sugar. Strings of more than two sugar molecules are called polysaccharides. This category includes compounds such as starches, cellulose and inulin.
Glucose and fructose are monosaccharides. Glucose and fructose are found abundantly in nature in fruits and plants. Sucrose is the disaccharide formed by the joining of glucose and fructose, also known as table sugar. When comparing their relative sweetness, glucose is the least sweet tasting, sucrose is next, and fructose is the sweetest of the three sugars, measured as 1.4 times sweeter than table sugar. Because it is so sweet, people typically use less fructose when sweetening foods compared to sucrose.
? In the article by Mr. Nagel he states , "fructose is not what is found in fruit. Commonly, fructose is compared with its opposite and truly naturally occurring sweetener, known as ‘levulose' (made by nature)..."
Another fabrication. In fact, levulose is just another name for fructose. There are various nomenclatures used in the scientific naming of compounds. Fructose and levulose are exactly the same thing; the names are interchangeable. It is no different than if you called your father, "dad", and your sibling called your father, "father". He would still be the exact same person. Fructose and levulose are different names for the exact same thing: a sugar found in nature.
Mr. Bianchi also is quoted to say that the body does not recognize the fructose in agave. This is another false piece of propaganda which demonstrates just how far he is reaching. If this were true, it would have no impact on us. He immediately contradicts himself with the claims of detrimental effects caused by the overconsumption of fructose.
Sugars can be compared to each other in their ability to raise blood sugar levels by using the Glycemic Index. The scale is set from zero to 100, where low numbers do not have much impact on blood sugar levels, and high numbers raise blood sugar levels quickly. Fructose is very low on the scale. Because agave syrup is high in fructose, it has a rating of 32 or lower. Honey, which has a higher proportion of glucose to fructose, has a Glycemic Index of 58. Sucrose has a Glycemic Index of 68, and glucose, serving as the index standard, is 100.
All sugars, whether fructose, glucose, sucrose or others, contribute 4 calories per gram to our total diet. 1 teaspoon of sugar = 4 grams = 16 calories
In addition to calories, sugars sweeten our foods offering a desirable taste and adding enjoyment and pleasure to our dining. During cooking and baking, sugars allow for browning and the unique consistencies of syrups, candies, frostings and frozen desserts. The varieties of sugars, such as crystallized table sugar, brown sugar, raw sugar, molasses, honey and agave nectar, among others, contribute different properties and flavors to foods.
When you add your own sugar to foods you are in control of how much sugar you use. Most people would never add as much sugar as do the food manufacturers. Moderate amounts of sugar can certainly be enjoyed as part of a healthy diet for an active individual. Natural sugars are easily metabolized and utilized by the body, offering a very efficient source of fuel for physical and mental activity.
Of course, sugars should be used in moderation in the diet. This can control calories and help create a diet that is dense in nutrients.
Impact of sugar on health and disease
? The remainder of Mr. Nagel's article works to link agave syrup with the increased incidence of obesity, diabetes, metabolic disease, and the general rise of morbidity and mortality in the population. This is an overconsumption issue involving far more than the occasional use of agave. Here are the facts:
• Rats that are fed a high fructose diet become obese and will develop the chronic diseases associated with obesity: insulin resistance, diabetes and metabolic disease.
• No one should eat a diet that reflects this type of experimental diet.
• Too much sugar in the diet, whether from fructose, glucose or sucrose, can be unhealthy. Diets high in sugar promote tooth decay and periodontal disease; create an overabundance of calories and a deficit of nutrients. This scenario typically leads to weight gain and the development of chronic disease.
• Active individuals can include a moderate amount of added sugar in their diet without negative health consequences. When calorie intake is balanced with physical activity, sugar serves as an efficient source of fuel for muscles, the brain and the central nervous system.
• According to the World Health Organization (2003), individuals can healthfully include 10% of their daily calories from added sugars. This translates into 200 calories for a 2000 calorie diet, or 12½ teaspoons of added sugar daily. Clearly, one can safely add a couple of teaspoons of sweetener to a cup of tea or coffee, or have a little sweetened food without worrying about their risk of developing disease.
• Agave syrup, which is sweeter than other sugars and low on the Glycemic Index scale, is a good choice to include as one of the added sugars in your diet because you will use less sugar (and therefore fewer calories) and minimally raise blood sugar levels.
Just a teaspoon of agave: the healthy use of sweeteners in your diet
We all want to live healthier and longer lives. Diet and nutrition plays a key role, impacting our health and our ability to perform physically and mentally now and into the future. Food offers us not only sustenance, but also pleasure and enjoyment. Food is present in so many parts of our lives: at celebrations, business events, family events, religious and spiritual occasions, sports outings, the focus of our family meals, intimate dinners, and sometimes just the excuse to socialize.
Sweet foods make us feel good. Sugar allows for the elevation of serotonin in our brains, the "feel good" neurotransmitter that elevates mood, helps us focus, and in the evening, helps us relax and sleep.
Sugar is a source of energy for our muscles, brain and central nervous system. Without sugar our bodies will not function at peak capacity.
Too much sugar, however, is not good. In small amounts sugar energizes us, but in large doses, repeated throughout the day, day in and day out, sugar puts stress on the body. The extra calories can lead to weight gain and obesity, which in time can lead to chronic disease. In the short term, high sugar intakes can lead to a nutritionally deficient diet and a sense of being on an emotional roller coaster.
So be selective about your use of sugars and use them in moderation in your diet. Just like all foods, a variety will enhance the nutritional content of your diet and the flavor and tastes that you can enjoy. Since sugars come in different forms and have different flavors, they can be used most effectively in specific foods and beverages. For instance, agave syrup is liquid and less viscous than honey, making it easy to mix into cold liquids like iced tea and coffee, and is great to add to cold unsweetened cereals for a little sweet taste. Agave's mild flavor allows chefs and bakers to sweeten foods lightly, without overpowering the taste of the dish.
Pay attention to how much sugar is added to your diet every day. Read labels so that you know when sugar is added to manufactured foods. Keep the consumption of added sugars in your diet to no more than 10% of your total daily calorie intake so that you have plenty of room for nutrient dense foods like fruits, vegetables, grains, dairy, protein-rich foods, nuts, seeds and healthy oils.
Remember that nutrition is a science based on facts. We are making great advances in our understanding of the science of foods and nutrition. Beware of people with hidden agendas using fear tactics to influence your choices. Don't take their opinion at face value. What are their credentials? What conflicts of interest do they have? If they do not disclose conflicts, then assume that they are manipulating the truth.
Most of all enjoy food. Think about what you need to eat to promote whole health. Don't overindulge, but don't deprive yourself of the bounty of wonderful tastes, either. Use celebrations as occasions to enjoy your favorite foods and try new ones. A teaspoon or two of sugar easily fits into the diet of an active, healthy person. Agave syrup offers an organic low-glycemic choice for those looking for that option.
Resources for this article:
Charley H. Food Science, 2nd Edition. John Wiley & Sons, New York, NY, 1982.
Figlewicz DP et al. Effect of moderate intake of sweeteners on metabolic health in the rat. Physiology and Behavior 98:618-624, 2009
Johnson RK et al. Dietary sugars intake and cardiovascular health: A scientific statement from the American Heart Association. Circulation: Journal of the American Heart Association, 2009
Tyler VE. The Honest Herbal, Third Edition. Pharmaceutical Products Press, New York, NY, 1993.
Royal Jelly As An Anti-Aging Supplement
February 27, 2010 11:45 AM
Author: Darrell Miller
Subject: Royal Jelly As An Anti-Aging Supplement
Royal jelly is considered to be the treasure of the beehive. It has the ability to promote longevity by helping to maintain healthy, beauty, and youth. This natural food is extremely potent and highly nutritional. Royal jelly is an incredibly rich, creamy, opalescent white liquid. It is produced by the worker bees specifically for the nourishment and cultivation of the queen bee. This fantastic material converts a common honeybee into a queen bee, extending the bee’s lifetime from six weeks to five years. This substance is full of natural hormones and B-vitamins. Additionally, it contains a variety of seventeen amino acids. Eight of these amino acids are essential. Royal jelly is particularly rich in cystine, lysine, and arginine and is also composed of 16.1 percent aspartic acid, which is crucial for proper tissue growth and regeneration.
Gelatin is another component of royal jelly and one of the primary precursors of collagen. It is a potent anti-aging compound that helps to keep the youthful, while supporting the organs, glands, and muscular systems. It contains vital fatty acids, sugars, sterols, phosphorus compounds, and acetylcholine. Acetylcholine is essential in order to properly transmit nerve impulses. It is also important for the proper functioning of the endocrine system. An insufficient amount of acetylcholine often leads to a susceptibility to a variety of nerve disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
Royal jelly has many properties. Among which include: antibacterial, antiviral, antibiotic, tonic, nutritive, and anti-aging. It is very beneficial to the immune, cardiovascular, endocrine, integumentary, nervous, reproductive, cellular, skeletal, hepatic, and respiratory systems.
Although aging is inevitable, the process can be slowed significantly with supplements. Researchers in Argentina have been working to document the ability of royal jelly to both slow down tissue deterioration and even reverse it. For example, the story of Noel Johnson should be noted, as he experienced of rebirth of health at age eighty. In 1964, at age sixty-five he was refused life insurance because of a weak and damaged heart. At this point he was also cautioned to restrict his physical activity in order to prevent death. In 1989, at age ninety, Johnson discussed the book he wrote, The Living Proof… I Have Found the Fountain of Youth, which claims that his use of bee products, along with a solid nutritional program, is responsible for changing his life. Despite the additional exercise and diet changes, Johnson attributes most of his vitality to the bee products he used. He claims that he discovered bee’s gift at age seventy, as the foods restored his manhood, brought him to full vigor and sexual potency, and continue to nourish every cell in his body. Johnson claims to be improving in every way without spending any money on medicine.
Royal jelly has been found to help with many conditions. Some of these include menopause, impotence, infertility, chronic fatigue, skin blemishes, wrinkles, immune system problems, viral and bacterial infections, endocrine disorders, hormonal balance, cardiovascular disease, weight control, inflammation, liver ailments, cancer, arthritis, memory, depression, Parkinson’s disease, diabetes, asthma, and mental exhaustion.
In order to obtain the best results when using this, or any bee product, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by royal jelly, please feel free to consult a representative from your local health food store with questions. Always buy Name brands like Premier One Royal Jelly to ensure quality and purity of the product you purchase.
Hops and St. John's Wort
July 15, 2009 12:17 PM
Author: Darrell Miller
Subject: Hops and St. John's Wort
St. John’s wort has emerged recently as an herb that is known to assist the nervous system. Quite a few naturopathic physicians rank kava kava, valerian, St. John’s wort, passionflower, and hops as the most effective herbs for treating insomnia. A study that took place in 1994 and was published in the Journal of Geriatric Psychiatry and Neurology proved that St. John’s wort extracts increased deep sleep during the total sleeping period of the patients. This study also makes an interesting connection between sleep and depression. It was found that many standard antidepressants and MAO inhibitors used to treat those people who suffer from depression cause a decrease in deep sleep. St. John’s wort has demonstrated the ability to treat both insomnia and depression.
Hops, an herb that is commonly found throughout the world, was originally used as a food. The tips of the food were both cooked and eaten. The young plants were the ones eaten because the older plants were too tough. A famous herbalist, Gerarde, recommended using the buds of these plants in salads, while the Romans anciently used hops as a food and Native American tribes found hops to be of great value. Hops have been appreciated for a long time for its nervine properties. A hop was first used as a beer ingredient in England around 1500. At this point, hops farmers noticed that their farmhands often seemed tired and easily fatigued. With time, the herb gained a huge reputation as a natural sedative. Pillows were filled with hops to promote rest and relaxation during the reign of King George when people were recovering from an illness.
Lupulin is a compound that is found in hops. It is described as a sedative and hypnotic drug. Certain parts of the plant have been found to have sedative and hypnotic effects. This herb is known to be fast-acting, soothing, and calming to the nervous system. Additionally, it is another nervine herb that assists in promoting sleep. It is mainly used to alleviate nervous tension and promote restful sleep. Also, hops is used for antispasmodic effects. Its relaxing effect has the potential to calm the nerves and muscles in cases of muscle spasms. This herb has also been shown to contain appetizing and tonic properties. It acts as a stimulant to the glands and muscles of the stomach, while calming the hyperexcitable gastric nerves. Hops also has a relaxing influence upon the liver and gall duct, and a laxative effect on the bowels.
Along with other uses, hops is also used for its antibiotic properties. It is very helpful for sore throats, bronchitis, infections, high fevers, delirium, toothaches, earaches, and pain. A hops remedy is a great way to help with inflammation, boils, tumors, and swelling. Hops is extremely high in B-complex vitamins, which are known for their calming effect on the nervous system. B vitamins also promote energy and aid in problems of depression, anxiety, nervousness, and memory. Additionally, hops is extremely rich in potassium, which is necessary for nerve transmission, contraction of muscles, and hormone secretion. Low levels of potassium are often found in those people who have high blood pressure. Additionally, hops contains magnesium, zinc, copper, iodine, manganese, iron, sodium, and fluoride.
Hops and st. Johns wort are a wonderful herb that has many therapeutic uses. Hops and st. Johns wort come in tea bag, capsule, and tablet forms at your local or internet health food store. For more information on St. John’s wort and hops, contact your local health food store.
August 15, 2008 03:51 PM
Author: Darrell Miller
DHA is the most abundant essential fatty acid (polyunsaturated fatty acids) found in the brain and retina. DHA is essential for the proper functioning of our brains as adults, and for the development of our nervous system and visual abilities during the first 6 months of life. DHA is found in cold water fatty fish, including salmon, tuna (blue fin tuna have up to five times more DHA than other types of tuna), mackerel, sardines, shellfish, and herring. Lets take a look at what DHA can do for you.
DHA makes infant formulas more like human milk than "conventional" formula containing Alpha-linolenic acid and linoleic acid, which are precursors to DHA. It has been an ingredient in several brands of premium infant formula sold in North America since 2001. Mead Johnson was the first infant formula manufacturer to add DHA and ARA (arachidonic acid) to its Enfamil Lipil product, several other manufacturers have followed. DHA levels in breast milk are higher if a mother's diet is high in fish.
DHA is also present normally in very high concentrations in the retina. DHA supplementation would be particularly important for mothers who have consumed excessive alcohol, because alcohol inhibits the desaturase enzymes necessary for DHA synthesis. Docosahexaenoic Acid (DHA) is a type of Omega-3 fatty acid, a nutrient that has been studied for its role in heart, brain and eye health. An experiment that studied the individual effects of EPA and DHA found that EPA reduced natural killer (NK) cell activity and cell-mediated immune response, but that DHA does not so this study concluded that the immune-suppressing effects of fish oil are mainly due to EPA, not DHA.
Omega-3 fatty acids found in fish oil help lower triglycerides (fats in the blood), lower blood pressure, reduce the risk of blood clots, improve the health of arteries and reduce the amount of arterial plaque (which narrows arteries and causes heart disease). Many people believe that excessively high omega-6 rather than omega-3 in the modern diet is responsible for an increase in allergies and the need to take aspirin to reduce the risk of heart attack (myocardial infarction).
Sunflower, safflower and corn oil are particularly rich sources of linoleic acid, which is at the root of the omega-6 fatty-acid family. The ability of enzymes to produce the omega-6 and omega-3 family of products of linoleic and alpha-linolenic acid declines with age this is why we need more omega 3 DHA in our diets. In fact, a high omega-3 fatty acid diet increases the alpha-tocopherol content of heart muscle membranes by five times, and this effect is most prominently associated with DHA because the heart muscle prefers DHA as its raw materials to manufacture and strengthen its membranes.
Dietary DHA may reduce the risk of heart disease by reducing the level of blood triglycerides in humans. Low levels of DHA result in reduction of brain serotonin levels and have been associated with ADHD, Alzheimer's disease, and depression, among other diseases, and there is mounting evidence that DHA supplementation may be effective in combating inflammatory bowel disease as well.
Dietary changes in the past century have lowered the consumption of omega-3 to a state of subclinical deficiency that is epidemiologically related to cardiovascular disease, inflammatory disorders, mental and psychiatric diseases and suboptimal neurodevelopment. Decreases in DHA in the brain are associated with cognitive decline during aging and with onset of sporadic Alzheimer disease. DHA has a positive effect on diseases such as hypertension, arthritis, atherosclerosis,, adult-onset diabetes, mellitus, thrombosis, and some cancers.
In conclusion, if consuming DHA through your diet is impossible, you can purchase DHA as a supplement in two common forms: Fish oil capsules or DHA extracted from algae. Consuming DHA may help support body tissues in which DHA is prevalent — especially the brain, nervous system, heart, retinas, and colon. Staying healthy is important, have you had your DHA today?
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July 31, 2008 02:46 PM
Author: Darrell Miller
Subject: Feverfew Leaves
Feverfew is most commonly used in the treatment and prevention of migraine headaches. Migraines are extremely common and can be very difficult to treat. Other methods of relieving pain have been explored because, for many migraine sufferers, conventional treatments have not been successful. Feverfew is one of the most successful forms of alternative treatments that have been found for treating migraines. Many studies have been conducted which have validated the already existing knowledge of many herbalists: feverfew is a great tool for helping to prevent migraines in many cases.
Although feverfew had long been used for treating headaches, its popularity declined with the advent of modern medicine. The herb has resurged into medical interest after the wife of a doctor who worked for the British National Coal Board had been suffering from migraines and was told by a coal miner to trey chewing on two feverfew leaves a day. After trying the herb, the woman noticed improvement, with fewer and less severe migraines. Her husband then urged a migraine specialist in London, Dr. E. Stewart Johnson, to test feverfew, with the results of several studies now showing it to be effective.
Dr. Johnson agreed to try the herb because he had many patients who had been suffering from migraine pain for years and had yet to find a successful treatment. Originally, he tried the herbal remedy on only ten of his patients. The results of this trial were so promising that it led to a study of another 270 of his patients, with seventy percent reporting that they received significant improvement when receiving feverfew for their headache pain.
Following this, a group of researchers in the City of London Migraine Clinic were led by Dr. Johnson to conduct a study, which was reported in the British Medical Journal, investigating seventeen patients who had already been using feverfew for at least three months. All were asked to discontinue use of their original method of treating with feverfew. Eight patients were given a capsule of feverfew, while the other nine were given a placebo.
Those that were given a placebo had an increase in frequency and severity of headaches, nausea, and vomiting, while those that were given feverfew capsules had no increase in frequency or severity of their migraines. This research has led to the belief that feverfew is advantageous in the prevention of migraines. Many other studies have been done to further test the effects of feverfew. It has been concluded that feverfew treatment is effective and there were always definite improvements in the group that used feverfew. Additionally, there were no serious side-effects that appeared to exist.
Feverfew seems to have similar properties as NSAIDs such as aspirin and ibuprofen. Also, the parthenolide that is found in feverfew is the main inhibitor for the formation of compounds that promote inflammation. Parthenolide reduces the secretory activity of blood platelets and white blood cells. This is important because migraines are thought to be associated with abnormal platelet behavior, as they are responsible for the release of serotonin, which constricts blood vessels and leads to migraine pain.
Feverfew is now recognized by the British and Canadian governments as a migraine treatment and is often prescribed by doctors. Many physicians and pharmacists have recent began to take more interest in the use of herbal remedies, especially since patients are beginning to become more interested in natural methods of healing.
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St. John's Wort
June 22, 2008 08:52 AM
Author: Darrell Miller
Subject: St. John's Wort
St. John's Wort is a plant with yellow flowers that researchers continue to look at for its health and well-being benefits. A perennial herb, it is from Europe and found its way to America with settlers. It is commonplace in meadows and fields. The first recorded use of St. John's Wort was in ancient Greece. It also goes by the following names: hypericum, Klamath weed and goat weed.
For centuries, this plant has found use as a medicine for depression and anxiety. People often used it to treat mental conditions and nerve pain. Today, people use the herb to treat sleep disorders and anxiety as well as a treatment for mild to moderate depression. In Europe, St. John's Wort is available as a prescription medicine and finds wide use there.
In the United States, it is an herbal supplement and does not have classification by the government as a prescription medicine. However, there is great interest in the U.S. in this herb's capabilities as treatment for depression. Studies show St. John's Wort has a minimal effect on major depression. There is evidence though that it is a useful herb for treating milder depression. Some studies show it acts similar to synthetic antidepressants by affecting the neurotransmitters in the brain. There is also evidence that it produces fewer side effects than these synthetics.
In North America, St. John's Wort comes in capsule, tablet, liquid extract, oil-based skin lotions and tea form. The flower tops of the plant find use in tea formulations. The major active elements in the herb, considered by some researchers as antidepressants, are hyperforin and hypericin. Studies suggest that the hyperforin in the herb plays a part in helping people decrease alcohol consumption. In addition, hyperforin has beneficial antibacterial properties. The plant also contains essential oils and flavonoids. Native Americans have a history of use of St. John's Wort as an anti-inflammatory, antiseptic and astringent agent.
If you decide to try St. John's Wort, you must consult with a health care professional first, as this herb interacts with other medications. Evidence shows that it can affect anticoagulant drugs and contraceptive pills. It can also affect medication needed to treat high blood pressure.
One study of St. John's Wort showed it was beneficial to a group who consumed 300 mg. three times daily compared to a group who took a placebo only. This study occurred over a four-week period. Sixty-seven percent of the St. John's Wort group experienced improvement of their depression compared to 28 percent of the placebo group. This study included only those suffering from mild depression. What was important in this study was that there were no adverse side effects from the St. John's Wort as compared to synthetic antidepressants. This was significant because many patients often refuse standard antidepressants because of the harmful and bothersome side effects they produce.
There is no denying that St. John's Wort has a long tradition as a medicine to treat anxiety and depression. This is why studies continue into its effectiveness. Researchers do not want to ignore repeated testimonials about the herb's antidepressant capabilities; they seek to make sure these claims are legitimate by having facts to back them up.
Thirty-seven trials that met criteria for being credible received recognition concerning St. John's Wort. They received summarization in a study. (Cochrane Database of Systematic Reviews 1998, Issue 4. Art. No.: CD000448. DOI: 10.1002/14651858.CD000448.pub2.)
The conclusion reached upon analysis of the studies showed St. John's Wort could benefit those with milder types of depression. No conclusive evidence exists that more severe types receive anything more than minimum benefits from the St. John's Wort products that were part of the studies. The researchers stress that their analysis applies only to certain products they tested, not every St. Johns Wort formulation on the market. Many are of different pharmaceutical quality and of different strengths and purities.
Research will continue into this natural product that the earth provides us. At the very least, St. John's Wort does help some forms of depression. The jury is out on whether its benefits will extend to those who suffer harsher forms of the debilitating mental condition that affects millions.
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Best Sugar Balance Svetol (green coffee extract)
May 05, 2006 06:30 PM
Author: Darrell Miller
Subject: Best Sugar Balance Svetol (green coffee extract)
Best Sugar Balance featuring Svetol® Svetol® is an extract of green coffee obtained by the use of a traditional patented extraction process from the beans of the species Coffea canephora robusta Pierre. This species is particularly rich in the constituent known as chlorogenic acid. Svetol® green coffee extract contains less than 2% caffeine. The extract is standardized to contain between 45-50% chlorogenic acids.
In vitro (test tube) and in vivo research suggests that chlorogenic acids present in coffee may have the ability to regulate blood sugar concentrations after meals by acting on the intestinal absorption of glucose and improving the body's glucose tolerance. Clinical evidence also suggests that Svetol® green coffee extract may help to maintain a healthy blood sugar level when used as a part of the diet.*
Maintains healthy blood sugar levels when used as a part of the diet*
Chlorogenic acid is the major polyphenol compound found in Svetol® green coffee bean extract. In vitro and animal studies have been conducted to determine the potential actions of this polyphenol. Studies report that chlorogenic acid and related compounds have significant antioxidant potential and are responsible for the high reported antioxidant benefit of green coffee. Several studies suggest that consumption of coffee in the diet is one factor that is correlated to the maintenance of healthy neural function and healthy aging. Coffee has also been shown in vitro to suppress the production of various free radicals. The chlorogenic acid content of coffee has been determined to be a major factor in the free radical quenching properties of coffee. A study was conducted to assess the activity of coffee extracts against the production of hydroxyl radicals in an in vitro system. It was found that coffee extracts possessed significant suppressive activity against hydroxyl radicals. Of the compounds assumed to be responsible for this effect, the researchers concluded that the chlorogenic acids played a major role with some contributions from other compounds found in the extract. This compound may also strongly contribute to any potential neuroprotective effects seen with coffee consumption.1
Two further studies highlight a possible mechanism by which chlorogenic acid mediates its antioxidant activity. In one study, the FRAP (Ferric Reducing Antioxidant Power) assay was used to measure and compare the iron-reducing capacity of chlorogenic acid and caffeine. It was shown that the chlorogenic acid content of the samples tested was highly correlated with iron-reducing activity in this assay. Moreover, lighter roasted coffee samples (closer in nature to green coffee) had the highest iron-reducing activity. Caffeine did not influence the iron-reducing activity of the coffee samples.2 Iron compounds are known to mediate the production of radicals and often serve as catalysts for their production in the body. A second study shows that chlorogenic acid can bind to and Chelate certain iron compounds, preventing them from catalyzing radical-producing reactions. In this way, chlorogenic acid acts as a powerful antioxidant.3
Chlorogenic acid and related compounds have a dual effect on the production and suppression of free radicals. In the case of the hydroxyl radical, studies outlined previously suggest that chlorogenic acid suppresses the production of the radical due to its ability to chelate iron compounds, while other studies suggest that chlorogenic acid has direct scavenging effects on the hydroxyl radical.4 Dietary intake of this potent polyphenol may confer multiple benefits to human health.
Several studies further suggest that chlorogenic acid in coffee can have a beneficial effect on blood sugar levels when consumed as a part of the diet. A recent study assessed the effects of coffee and tea consumption on glucose tolerance in middle-aged Japanese men. In this study, the relationship between daily intakes of green tea or coffee and glucose tolerance status was measured by the oral glucose tolerance test (OGTT). More than 3,400 men participated in the study in which fasting glucose was measured before and 2 hours after administration of an oral glucose load. A self-administered questionnaire was used to establish daily levels of dietary coffee and green tea consumption over the past year. The results showed that those individuals who consumed the highest levels of coffee per day had lower fasting glucose levels (by 1.5%) and lower post-test glucose concentrations (4.3% lower) than those who did not consume coffee Chlorogenic acid and related compounds have a dual effect on the production and suppression of free radicals. In the case of the hydroxyl radical, studies outlined previously suggest that chlorogenic acid suppresses the production of the radical due to its ability to chelate iron compounds, while other studies suggest that chlorogenic acid has direct scavenging effects on the hydroxyl radical.4 Dietary intake of this potent polyphenol may confer multiple benefits to human health.
Several studies further suggest that chlorogenic acid in coffee can have a beneficial effect on blood sugar levels when consumed as a part of the diet. A recent study assessed the effects of coffee and tea consumption on glucose tolerance in middle-aged Japanese men. In this study, the relationship between daily intakes of green tea or coffee and glucose tolerance status was measured by the oral glucose tolerance test (OGTT).
More than 3,400 men participated in the study in which fasting glucose was measured before and 2 hours after administration of an oral glucose load. A self-administered questionnaire was used to establish daily levels of dietary coffee and green tea consumption over the past year.
The results showed that those individuals who consumed the highest levels of coffee per day had lower fasting glucose levels (by 1.5%) and lower post-test glucose concentrations (4.3% lower) than those who did not consume coffee on a daily basis. In this study, green tea consumption was not associated with any benefits on glucose concentrations.5
It is likely that the chlorogenic acid found in coffee plays a role in supporting healthy glucose metabolism, whereas the role of caffeine is not clear, with some reports suggesting an adverse effect on sugar metabolism.
A second study further confirms an effect of chlorogenic acid at inhibiting the absorption of glucose from the diet. This effect occurs in the small intestine. In this study, nine healthy fasted volunteers consumed 25 grams of glucose in 400 ml of water (the control group), caffeinated coffee, or decaffeinated coffee. Frequent blood samples were taken over the next 3 hours. It was found that glucose and insulin concentrations were higher 30 minutes after the consumption of caffeinated coffee than with either decaffeinated coffee or control (water).While caffeine has specific biological effects on raising glucose levels and impacting insulin profiles, chlorogenic acid was shown to have an antagonistic effect on glucose transport. Previous studies have also shown that chlorogenic acid significantly delays glucose uptake from the small intestine.6
RESEARCH ON SVETOL®
Svetol® is a unique extract of Coffea canephora robusta green coffee beans containing between 45 and 50% chlorogenic acids with less than 2% total caffeine concentration. As outlined above, many studies highlight the potential benefits of coffee compounds, including chlorogenic acid, for providing protection against free radicals and promoting healthy glucose metabolism. A number of other potential benefits have been discovered for these compounds. Svetol® has also been the subject of preliminary clinical studies that have shown exciting results.
In a pilot study, the effect of Svetol® on sugar concentrations after meals was evaluated in 15 individuals. In the same trial, the longer-term effects of Svetol® on weight management were also evaluated. Blood sugar concentrations were measured on two separate occasions. Patients were administered an oral glucose tolerance test (OGTT) in which they consumed a standard amount of sugar and had their blood sugar levels measured 1 hour after sugar intake. The first measurement was made on day 1 prior to taking Svetol® and the second OGTT was performed on day 2, after beginning the Svetol® regimen in which one tablet (200 mg per tablet) was administered 3 times during the day. Patients were fasted for at least 8 hours prior to the testing. The results showed that Svetol® was able to reduce blood sugar concentrations in 60% of the subjects. The mean reduction of blood sugar concentration in these individuals was 50%. The treatment was continued following the same regimen for 6 weeks to assess the impact of Svetol® on weight. The average weight loss of the participants was 1.5 kg (3.3 lbs) over the treatment period. 7
Based on the studies mentioned above and other related research on the ingredients in Svetol®, scientists have proposed two mechanisms of action whereby Svetol® may influence the metabolism and processing of glucose. The first mechanism seems to be an inhibitory action on glucose absorption from the diet. Svetol® may affect the uptake of glucose in the small intestine by modulating factors needed for sugar absorption.
The second mechanism relates to possible effects of Svetol® in the liver's ability to produce glucose. Chlorogenic acids have been shown in vitro and in animal studies to modulate the effects of certain enzymes in the liver that catalyze the production of glucose. By having this dual effect on sugar absorption and sugar production, Svetol® is an effective product for maintaining healthy blood sugar levels when used as a part of the diet.*
Svetol® is a natural food extract from green coffee beans containing a standardized amount of chlorogenic acid. Studies have shown that chlorogenic acid (up to 500 mg/kg/day) given to pregnant rats from the 5th through 12th day of gestation caused no maternal or fetal mortality and no adverse effects on the nervous system. Chlorogenic acids have also been shown to be non-mutagenic in tests on bacteria such as the Ames test. The LD50 of chlorogenic acids has been determined to be higher than 2500 mg/kg body weight. Svetol® is also extremely low in caffeine, with less than 2% caffeine contained in the extract, and is not expected to have any of caffeine's stimulant effects. Svetol® is extremely safe with no adverse effects having been reported while taking Svetol® at the recommended dosage.7
*This statement has not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease.
1) Daglia M, Racchi M, Papetti A, Lanni C, Govoni S,Gazzani G. In vitro and ex vivo antihydroxyl radical activity of green and roasted coffee. J Agric Food Chem.2004 Mar 24;52(6):1700-4.
2) Moreira DP, Monteiro MC, Ribeiro-Alves M, Donangelo CM, Trugo LC. Contribution of chlorogenic acids to the iron-reducing activity of coffee beverages. J Agric Food Chem. 2005 Mar 9;53(5):1399-402.
3) Kono Y, Kashine S,Yoneyama T, Sakamoto Y, Matsui Y, Shibata H. Iron chelation by chlorogenic acid as a natural antioxidant. Biosci Biotechnol Biochem. 1998 Jan;62(1):22-7.
4) Zang LY, Cosma G, Gardner H, Castranova V, Vallyathan V. Effect of chlorogenic acid on hydroxyl radical. Mol Cell Biochem. 2003 May;247(1-2):205-10.
5) Yamaji T, Mizoue T, Tabata S, Ogawa S, Yamaguchi K, Shimizu E, Mineshita M, Kono S. Coffee consumption and glucose tolerance status in middle-aged Japanese men.Diabetologia. 2004 Dec;47(12):2145-51. Epub 2004 Dec 15.
6) Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78(4):728-33.
7) Berkem.Text on Svetol®.Gardonne, France: November 2005.
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Folic Acid: Strengthening the Immune System in the Elderly
January 09, 2006 09:38 AM
Author: Darrell Miller
Subject: Folic Acid: Strengthening the Immune System in the Elderly
Folic Acid: Strengthening the Immune System in the Elderly
By Greg Arnold, DC, CSCS, December 20, 2005, abstracted from “Dietary folate improves age-related decreases in lymphocyte function” in the January 2006 issue of the Journal of Nutritional Biochemistry Recent research has elucidated health-promoting roles for folic acid beyond that of insuring normal development of the fetus. In addition to helping decrease neural tube defects,1 folic acid can also help treat inflammatory bowel disease 2 improve memory 3 and help decrease an amino acid in the body, homocysteine,4 that increases heart disease risk.5 Now a new study 6 has found another way that folic acid can help us age more gracefully: by helping strengthen our immune system. Recognizing the importance of nutrition in the overall health of the immune system 7 and knowing that certain types of immune system cells, called “T cells”, decrease with age,(8,9) researchers fed 11-month-old and 23-month-old male rats either a control diet or a diet fortified with 35.7 mg per kg of folic acid for three weeks. Researchers found “a significant” increase in immune system strength in the folic acid group, specifically that of increased T cell levels, other immune system proteins called IL-2, IL-4, and anti-cancer proteins called “tumor necrosis factor”. While the study reaffirmed the immune system’s weakening with increasing age, the researchers concluded that “supplementing…with additional folate improves [immune system function] and that dietary folate requirement may be higher in the older population than in the younger population to support immune functions.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com Reference:
1 “Spina Bifida and Anencephaly Before and After Folic Acid Mandate --- United States, 1995--1996 and 1999—2000” from MMWR Weekly 2004; 53(17): 362-365
2 Danese S. Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease. Am J Gastroenterol. 2005 Apr;100(4):886-95
3 “The First Ever Dementia Conference Opens In Washington, DC” posted on the Alzheimer’s Association Website www.alz.org/preventionconference/pc2005/overview.asp
4 Daly S. Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age. QJM. 2002 Nov;95(11):733-40
5 Stampfer J. Homocysteine levels and cardiovascular disease. Am Fam Physician. 1997 Oct 15;56(6):1568, 1571-2
6 C.J. Field, I.R. Johnson and P.D. Schley, Nutrients and their role in host resistance to infection, J Leukoc Biol 71 (2002), pp. 16–32
7 L. Haynes, S.M. Eaton, E.M. Burns, M. Rincon and S.L. Swain, Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo, J Immunol 172 (2004), pp. 5194–5199
8 R.B. Effros, Replicative senescence of CD8 T cells: effect on human ageing, Exp Gerontol 39 (2004), pp. 517–524
New Test for Early Cancer Detection
October 18, 2005 10:17 AM
Author: Darrell Miller
Subject: New Test for Early Cancer Detection
A new test for early cancer detection
Researchers out of Johns Hopkins University believe they may have found a new method of testing for cancerous growths that allows for much earlier detection. The new method of testing saliva and urine does not work for all cancers but would allow doctors to check for DNA abnormalities in these fluids. If these tests prove viable, they would allow for cancer detection years before symptoms appear.
Tests on patients suffering from cancers of the lung, voice box, mouth, throat and bladder showed 100 percent sensitivity to abnormal DNA particles. Researchers say that a mutation in the tumor guaranteed a detection in the bodily fluid.
The test works by detecting DNA strands that have been dumped by the tumor into the bloodstream and excreted by the body. These mutated DNA strands lead to dysfunctional cell division and give rise to tumor development and growth. In order to further test their theory, researchers tested a urine sample of the late U.S. Vice President Hubert Humphrey taken nine years before he was diagnosed with urinary cancer. The test showed the presence of DNA mutations.
Researchers are optimistic that these studies can push cancer detection up two, four or more years from its current position. New tests are being developed that search for more numerous DNA strands and are 200 times more sensitive than the original test. Major clinical research for these tests will begin next year.
Cancer fighter found in broccoli
July 27, 2005 10:05 AM
Author: Darrell Miller
Subject: Cancer fighter found in broccoli
Remember when your mother told you to eat your broccoli? Research shows that mother just might know best. In a recently published paper, Dr. Paul Talalay of Johns Hopkins University School of Medicine indicates that studies in his lab show broccoli is rich in sulforaphane, a chemical that works as a powerful anti-cancer compound in laboratory mice.
Other studies have shown that a diet rich in cruciferous vegetables—which include broccoli, Brussels sprouts, cabbage, cauliflower, and others— can significantly reduce the risk of cancer of the bowel, stomach and breast. Until now, the exact reasons why these vegetables had this effect we re not very clear. Until now, that is. According to Dr. Talalay, it appears that at least one anticancer ingredient in the vegetables is sulforaphane, which essentially causes cells to expel cancer-causing toxins. In addition, Dr. Talahay said that this study was the first to show that a high-potency compound isolated from vegetables could accelerate the detoxification process in cells.
The published report outlines how the research team isolated sulforaphane from broccoli, then fed it to a group of mice. When cells in the mice we re examined after five days, the scientists found that the chemical had triggered enzymes known to neutralize carcinogens within cells. Be yond this study, Dr. Talalay indicates that research will shift to the long-term effects of the chemical. “Our prediction is that sulforaphane will block tumor formation in animals and presumably in man.” In earlier studies, Dr. Talalay and others have shown that certain proteins in cells, called phase I enzymes, can take innocent chemicals and turn them into cancer-causing agents.
Other proteins, called phase 2 enzymes, tend to block formation of carcinogens. According to the study, sulforaphane is a potent activator of phase 2 enzymes. The Hopkins researchers will conduct tests to determine how much broccoli must be consumed to establish an effective anti-cancer level of sulforaphane in cells.
Over a decade of research has been done on cruciferous vegetables and there are large databases that confirm that cruciferous vegetables substantially reduce the risk of disease, specifically cancer. Studies show substances in these vegetables that have anti-cancer properties which cause the body to speed up production of enzymes, therefore being capable of neutralizing cancer agents. The studies also show these pre vent damage to our DNA and slow the aging process. In women, metabolic processes are regulated which eliminate the bad (and maintain the good) estrogen, therefore substantially reduce the risk of breast cancer. Shortly after the NCI study was released, John Hopkins School of Medicine revealed similar studies.
More Benefits of Natural Progesterone - PROGESTERONE AND CANCER
July 25, 2005 10:22 PM
Author: Darrell Miller
Subject: More Benefits of Natural Progesterone - PROGESTERONE AND CANCER
More Benefits of Natural Progesterone
PROGESTERONE AND CANCER
The two types of cancer that are hormonally related include breast and uterine cancer due to the fact that the tissue which make up these areas are much more sensitive to hormone levels. It is a well known fact that an excess of estrogen can increase the risk of developing uterine cancer and certain types of estrogen have been linked to the formation of malignant breast tumors.25 Any woman who continually suffers from insufficient progesterone can also increase her chances of developing certain types of cancer. A prolonged lack of progesterone can cause uterine changes which eventually result in the impaired shedding of the uterine lining. When this occurs month after month, endometrial hyperplasia can result, which is the abnormal thickening of the uterine lining. This buildup can lead to the development of uterine cancer. Progesterone can actually reduce the risk of developing uterine cancer which can develop from using estrogen therapy. 26 In addition, for women who have survived uterine cancer and have undergone hysterectomies, natural progesterone can be invaluable.
Because these women are advised to forgo hormonal treatments of any kind, they often suffer with osteoporosis or other symptoms typical of menopause. Taking natural progesterone poses no health risks and can help to prevent or treat these disorders. Concerning this group of women Dr. Lee writes:
These are the women for whom I first began using natural progesterone therapy. Not only did progesterone reverse their osteoporosis and, in many, it corrected their vaginal atrophy, but none, to my knowledge, have ever developed cancer of any sort . . . The evidence is overwhelming that natural progesterone is safe and only estradiol, estrone and the various synthetic estrogens and progestins are to be avoided to reduce the risk of endometrial cancer.27
In the case of breast cancer, studies strongly suggest that this type of malignancy is more likely to occur in premenopausal women who have normal or high estrogen levels and low progesterone levels.28Women over 35 who continue to have periods but no longer ovulate and women who are taking synthetic estrogen without progesterone during and after menopause may find themselves in this higher risk group. One of the most interesting studies on progesterone was conducted at Johns Hopkins University in 1981, where physicians studied 1083 women for between 13 to 33 years in assessing the incidence of breast cancer. They found that those women who had a progesterone deficiency were over 5 times more at risk of developing breast cancer than those women who had adequate progesterone levels.29 Moreover, the study found that women who suffered from a lack of progesterone also had ten times more cancer-related death from all types of malignancies than those who did not.30 These statistics are dramatic, to say the least. Consider the following quote:
. . . the evidence is strong that unopposed estradiol and estrone [two forms of estrogen] are carcinogenic for the breasts, and both progesterone and estri-ol, the two major hormones throughout pregnancy, are protective against breast cancer. One is left to wonder why supplementation with these two beneficial and safe hormones are not the ones used routinely for women whenever hormone supplementation seems indicated . . . both hormones are available and are relatively inexpensive. Why have these two hormones been neglected by contemporary medical practice in favor of synthetic substitutes. 31
Pain - Post Op and Relaxation
July 13, 2005 09:24 AM
Author: Darrell Miller
Subject: Pain - Post Op and Relaxation
Relaxation, Music Reduce Post-Op Pain. New research has found that relaxation and music, separately or together, significantly reduce patients' pain following major abdominal surgery. The study, published in the May issue of the journal Pain, found that these methods reduce pain more than pain medication alone. Led by Marion Good, PhD, RN, of Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, the study is supported by the National Institute of Nursing Research (NINR), at the National Institutes of Health. "This is important news for the millions of Americans who undergo surgery and experience postoperative pain each year," said Dr. Patricia A. Grady, director of the NINR.
"Better pain management can reduce hospital stays and speed recovery, ultimately improving patients' quality of life." Dr. Good and her research team studied three groups of patients undergoing abdominal surgery. In addition to the usual pain medication, one group used a jaw relaxation technique, another group listened to music, and a third group received a combination of relaxation and music.
Findings revealed that, after surgery, the three treatment groups had significantly less pain than the control group, which received only pain medication. "Both medication and self-care methods which involve patient participation are needed for relief," said Dr. Good.
"These relaxation and music self-care methods provide more complete relief without the undesired side effects of some pain medications." The findings have important implications for the 23 million people who undergo surgery and experience postoperative pain annually in the United States. Pain can hamper recovery by heightening the body's response to the stress of surgery and increasing tissue breakdown, coagulation and fluid retention. Pain also interferes with appetite and sleep and can lead to complications that prolong hospitalization.
Dr. Good and her research staff worked with 500 patients aged 18-70, who were undergoing gynecological, gastrointestinal, exploratory or urinary surgery. Prior to surgery, those in the music, relaxation or combination groups practiced the techniques. The relaxation technique consisted of letting the lower jaw drop slightly, softening the lips, resting the tongue in the bottom of the mouth, and breathing slowly and rhythmically with a three-rhythm pattern of inhale, exhale and rest. Patients in the music group chose one of five kinds of soothing music--harp, piano, synthesizer, orchestral or slow jazz.
On the first and second days after surgery, all patients received morphine or Demerol for pain relief by pressing a button connected to their intravenous patient controlled analgesia pumps. The groups receiving the additional intervention used earphones to listen to music and relaxation tapes during walking and rest, while the control group did not. The research team measured the patients' pain before and after 15 minutes of bed rest and four times during walking to see if the sensation and distress of pain changed.
Dr. Good found that during these two days postsurgery the three treatment groups had significantly less pain than the control group during both walking and rest. "Patients can take more control of their postoperative pain using these self-care methods," says Dr. Good. "Nurses and physicians preparing patients for surgery and caring for them afterwards should encourage patients to use relaxation and music to enhance the effectiveness of pain medication and hasten recovery."
Dr. Good's findings have implications for future research into the effectiveness of self-care methods on other types of pain, including chronic pain, cancer pain, and pain of the critically ill.
Vitamin D Lack Linked to Hip Fracture. Vitamin D deficiency in post-menopausal women is associated with increased risk of hip fracture, according to investigators at Brigham and Women's Hospital in Boston, Mass. In a group of women with osteoporosis hospitalized for hip fracture, 50 percent were found to have a previously undetected vitamin D deficiency. In the control group, women who had not suffered a hip fracture but who were hospitalized for an elective hip replacement, only a very small percentage had vitamin D deficiency, although one-fourth of those women also had osteoporosis. These findings were reported in the April 28, 1999, issue of the Journal of the American Medical Association.
The study, conducted by Meryl S. LeBoff, MD; Lynn Kohlmeier, MD; Shelley Hurwitz, PhD; Jennifer Franklin, BA; John Wright, MD; and Julie Glowacki, PhD; of the Endocrine Hypertension Division, Department of Internal Medicine, and Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, was supported by grants from the National Institute on Aging (NIA) and the National Center for Research Resources (NCRR. These investigators studied women admitted to either Brigham and Women's Hospital or the New England Baptist Hospital, both in Boston, between January 1995 and June 1998.
A group of 98 postmenopausal women who normally reside in their own homes were chosen for the study. Women with bone deterioration from other causes were excluded from the study.
There were 30 women with hip fractures caused by osteoporosis and 68 hospitalized for elective joint replacement. Of these 68, 17 women also had osteoporosis as determined by the World Health Organization bone density criteria. All the participants answered questions regarding their lifestyle, reproductive history, calcium in their diet, and physical activity.
Bone mineral density of the spine, hip, and total body were measured by dual X-ray absorptiometry (DXA) technique, as was body composition. Blood chemistry and urinary calcium levels were analyzed. The two groups of women with osteoporosis did not differ significantly in either time since menopause or bone density in the spine or hip. They did, however, differ in total bone density.
The women admitted for a hip fracture had fewer hours of exercise than the control group. Fifty percent of the women with hip fractures were deficient in vitamin D, 36.7 percent had elevated parathyroid hormone (PTH) levels (a hormone which can stimulate loss of calcium from bone), and 81.8 percent had calcium in their urine, suggesting inappropriate calcium loss. Blood levels of calcium were lower in the women with hip fractures than in either elective group.
These researchers propose that vitamin D supplementation at the time of fracture may speed up recovery and reduce risk of fracture in the future. Current Dietary Reference Intake Guidelines contain a daily recommendation of 400 IU of vitamin D for people aged 51 through 70 and 600 IU for those over age 70.
"We know that a calcium-rich diet and regular weight-bearing exercise can help prevent osteoporosis. This new research suggests that an adequate intake of vitamin D, which the body uses to help absorb calcium, may help women to reduce their risk of hip fracture, even when osteoporosis is present," observed Dr. Evan C. Hadley, NIA Associate Director for geriatrics research.
"Osteoporosis leads to more than 300,000 hip fractures each year, causing pain, frequent disability, and costly hospitalizations or long-term care. "Prevention of such fractures would greatly improve the quality of life for many older women and men, as well as significantly reduce medical costs." The bones in the body often undergo rebuilding. Some cells, osteoclasts, dissolve older parts of the bones. Then, bone-building cells known as osteoblasts create new bone using calcium and phosphorus.
As people age, if osteoporosis develops, more bone is dissolved than is rebuilt, and the bones weaken and become prone to fracture. Also in many older persons, levels of vitamin D in the blood are low because they eat less or spend less time in the sun, which stimulates the body's own production of vitamin D.
Experts do not understand fully the causes of osteoporosis. However, they do know that lack of estrogen which accompanies menopause, diets low in calcium, and lack of exercise contribute to the problem. Eighty percent of older Americans who face the possibility of pain and debilitation from an osteoporosis-related fracture are women. One out of every two women and one in eight men over the age of 50 will have such a fracture sometime in the future. These fractures usually occur in the hip, wrist, and spine.
Sleep Apnea, Diabetes Link Found. Adults who suffer from obstructive sleep apnea are three times more likely to also have diabetes and more likely to suffer a stroke in the future, according to a new UCLA School of Dentistry/Department of Veterans Affairs study published today in the Journal of Oral and Maxillofacial Surgery. Sleep apnea, a serious condition marked by loud snoring, irregular breathing and interrupted oxygen intake, affects an estimated nine million Americans. The culprit? Carrying too many extra pounds.
"The blame falls squarely on excess weight gain," said Dr. Arthur H. Friedlander, associate professor of oral and maxillofacial surgery at the UCLA School of Dentistry and associate chief of staff at the Veterans Affairs Medical Center in Los Angeles. Surplus weight interferes with insulin's ability to propel sugars from digested food across the cell membrane, robbing the cells of needed carbohydrates. Diabetes results when glucose builds up in the bloodstream and can't be utilized by the body. Being overweight can also lead to obstructive sleep apnea, according to Friedlander.
"When people gain too much weight, fatty deposits build up along the throat and line the breathing passages," he explained. "The muscles in this region slacken during sleep, forcing the airway to narrow and often close altogether." Reclining on one's back magnifies the situation. "When an overweight person lies down and goes to sleep," Friedlander said, "gravity shoves the fat in the neck backwards. This blocks the airway and can bring breathing to a halt."
Friedlander tested the blood sugar of 54 randomly selected male veterans whom doctors had previously diagnosed with obstructive sleep apnea. He discovered that 17 of the 54 patients, or 31 percent, unknowingly suffered from adult-onset diabetes. Using the same sample, Friedlander also took panoramic X-rays of the men's necks and jaws. The X-rays indicated that 12 of the 54 patients, or 22 percent, revealed calcified plaques in the carotid artery leading to the brain.
These plaques block blood flow, significantly increasing patients' risk for stroke. Seven of the 12, or 58 percent, were also diagnosed with diabetes. In dramatic comparison, the 17 patients diagnosed with diabetes showed nearly twice the incidence of blockage. Seven of the 17 men, or 41 percent, had carotid plaques. Only five of the 54 patients who displayed plaques did not have also diabetes. If he conducted this study today, Friedlander notes, he would likely find a higher number of diabetic patients. After he completed the study in 1997, the American Diabetes Association lowered its definition for diabetes from 140 to 126 milligrams of sugar per deciliter of blood.
"This is the first time that science has uncovered a link between sleep apnea and diabetes," said Friedlander. "The data suggest that someone afflicted with both diabetes and sleep apnea is more likely to suffer a stroke in the future." "Persons going to the doctor for a sleep-apnea exam should request that their blood be screened for diabetes, especially if they are overweight," he cautioned. More than half of the individuals who develop diabetes as adults will need to modify their diet and take daily insulin in order to control the disease, he added.
Stress, Surgery May Increase CA Tumors. Stress and surgery may increase the growth of cancerous tumors by suppressing natural killer cell activity, says a Johns Hopkins researcher.
Malignancies and viral infections are in part controlled by the immune system's natural killer (NK) cells, a sub-population of white blood cells that seek out and kill certain tumor and virally infected cells. In a study using animal models, natural killer cell activity was suppressed by physical stress or surgery, resulting in a significant increase in tumor development.
These findings suggest that protective measures should be considered to prevent metastasis for patients undergoing surgery to remove a cancerous tumor, according to Gayle Page, D.N.Sc., R.N., associate professor and Independence Foundation chair at the Johns Hopkins School of Nursing. "Human studies have already found a connection between the level of NK activity and susceptibility to several different types of cancer," says Page, an author of the study.
"We sought to determine the importance of stress-induced suppression of NK activity and thus learn the effects of stress and surgery on tumor development. "Many patients undergo surgery to remove cancerous tumors that have the potential to spread. If our findings in rats can be generalized to such clinical settings, then these circumstances could increase tumor growth during or shortly after surgery." The research was conducted at Ohio State University College of Nursing and the Department of Psychology at UCLA, where Page held previous positions, and at Tel Aviv University.
Results of the study are published in the March issue of the International Journal of Cancer. In laboratory studies, Page and her colleagues subjected rats to either abdominal surgery or physical stress, and then inoculated them with cancer cells. In the rats that had undergone surgery, the researchers observed a 200 to 500 percent increase in the incidence of lung tumor cells, an early indicator of metastasis, compared with rats that had not received surgery.
The experiment also showed that stress increased lung tumor incidence and significantly increased the mortality in the animals inoculated with cancer cells. "Our results show that, under specific circumstances, resistance to tumor development is compromised by physical stress and surgical intervention," says Page.
"Because surgical procedures are life-saving and cannot be withheld, protective measures should be considered that will prevent suppression of the natural killer cell activity and additional tumor development. "Researchers do not yet know how to prevent surgery-induced immune suppression, but early animal studies have shown increased use of analgesia reduces the risk."
The study was funded by the National Institutes of Health, and the Chief Scientist of the Israeli Ministry of Health. Lead author was Shamgar Ben-Eliyahu, Ph.D., and other authors were Raz Yirmiya, Ph.D., and Guy Shakhar.
June 25, 2005 08:13 PM
Author: Darrell Miller
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Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.
7-Keto - The Key to Healthy Aging
June 21, 2005 05:05 PM
Author: Darrell Miller
Subject: 7-Keto - The Key to Healthy Aging
7-Keto " The Key to Healthy Aging
The global population is aging at an alarming rate and causing an explosion in health care costs, insurance premiums, cosmetic surgery and more. In the U.S. alone, more than one million baby boomers are expected to live to 100 years of age or older. This increased life expectancy presents a whole new set of health concerns that the medical community has not had time to address, since there is a greater need to care for age-related health problems in this ever-growing elderly population.1
Aging and the Decline in Vital Nutrients
We all grow old at the same rate but people age at different rates. Aging is a process of gradual changes that occur to varying degrees in each of us. Interestingly, the aging process is composed of different components and interactions, some of which can be impacted. One such component is the declining level of essential biological compounds, which causes our bodily functions to slow and become dysfunctional. Our organs don?t work efficiently, our immune system becomes lazy, we lack energy, our metabolism drops and we gain weight easily.1 7-oxo DHEA (7-Keto™) is a naturally occurring compound that declines with age.2 Replacing this key metabolite helps promote a healthy immune system and maintains resting metabolic rate at levels that accelerate weight loss during standard weight reduction programs.
Aging and a Healthy Immune System
Numerous changes occur in the immune system with advancing age, probably contributing to decreased immune responsiveness. Although all segments of the immune system are affected, investigators have most consistently identified declines in cellular or T-cell mediated immune function in the elderly. The decline in T-cell immune function is generally associated with an increased susceptibility to foreign organisms. For example, individuals with age-related declines in cellular immunity have an impaired response to vaccinations, making them more susceptible to health imbalances even though they have had their shots. In a clinical study presented at the Federation of American Societies for Experimental Biology meeting in April 2004, the effect of 7-Keto on elderly immune function was evaluated. Healthy elderly adults were given 7-Keto orally twice daily over a period of one month. The study revealed that 7-Keto augmented several key T-cell mediated immune function parameters compared to placebo administration.4
Age-Related Weight Gain
Age-related weight gain and obesity are approaching epidemic proportions in our country.5 Weight gain is a disorder of energy balance involving energy intake and/or expenditure. Low energy expenditure, a drop in resting metabolic rate (RMR), is a challenge during most weight loss attempts due to age, calorie restriction, lack of physical activity or a combination of factors. RMR represents 60% of total daily energy expenditure. Maintaining a higher RMR as we age and during weight reduction programs helps us achieve and maintain a normal weight. Furthermore, compounds with the thermogenic potential to achieve even minimal increases in daily energy expenditure of 2-3% may have clinical relevance in preventing the decline in RMR with calorie restricted diets or weight loss, and in decreasing the risk of regaining weight. 7-Keto, a non-stimulant thermogenic compound, has been shown to significantly increase energy expenditure in humans.6 A recently completed clinical study, also presented at the Federation of American Societies for Experimental Biology 2004 meeting, revealed that administration of 7-Keto to overweight adults in conjunction with a calorie restricted diet effectively reversed the decline in RMR normally associated with dieting. Obese participants following a calorie-restricted diet demonstrated a 5.4% increase in daily RMR with 7-Keto.7 The magnitude of the increase in RMR by 7-Keto is clinically relevant, and represents a promising agent for enhancing thermogenesis and weight loss in obese individuals on calorie-restricted diets. Additionally, 7-Keto has been shown in two confirmatory published clinical studies to result in three times more weight loss compared to diet and exercise alone. It has a favorable side effect profile and is easy and convenient to take.8,9 Our life expectancies will likely be longer than those of our parents, and our quality of life during those years will depend on how well we take care of our bodies now. Undoubtedly, the science of aging will give rise to new and exciting technologies to help us age more gracefully and healthfully. Maintenance of healthy immune function is keenly needed for improved quality of life in the elderly. Dietary manipulation and supplementation has been identified as a method of immune system renewal, and supplements such as 7-Keto may play an important future role as immune system modulators. Moreover, the addition of 7-Keto to any weight loss program will offer vital support of energy expenditure and help with the attainment of a manageable and healthy weight into our older years.
1. 1995 White House Conference on Aging, ?Executive Summary: The Road to an Aging Policy for the 21st Century," February 1996: 17-18. 2. Marenich LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-Keto-Dehydroepiandrosterone in Healthy Men of Different Ages. Prob Endokrinol. 1979; 25(4): 28-31. 3. Ginaldi L, De Martinis M, D?Ostilio A, Marini L, Loreto MF, Quaglino D. Immunological Changes in the Elderly. Aging 1999; 11(5): 281-286. 4. Zenk JL, Kuskowski MA. The Use of 3-acetyl-7-oxo-dehydroepiandrosterone for Augmenting Immune Response in the Elderly, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 5. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and Trends in Obesity Among US Adults. 1999-2000. JAMA 2002;288:1723-1727. 6. Astrup A. Thermogenic Drugs as a Strategy for Treatment of Obesity. Endocrine 2000;13(2):207-212. 7. Zenk JL, Leikam SA, Kassen LJ, Kuskowski MA. A Prospective, Randomized, Double Blind Study to Evaluate the Effect of HUM5007 and 7-oxo DHEA on Resting Metabolic Rate in Overweight Adult Men and Women on a Calorie Restricted Diet, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 8. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. A Randomized, Double-Blind, Placebo Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Overweight Adults. Current Therapeutic Research 2000;61: 435-442. 9. Zenk JL, Helmer TR, Kassen LJ, Kuslowski MA. The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial. Current Therapeutic Research 2002; 63:263-272.
John L. Zenk, M.D., is Chief Medical and Scientific Officer for Humanetics Corporation and President and Medical Director of Minnesota Applied Research Center, both located in Eden Prairie, MN. He has spoken nationally and internationally on the subjects of integrating conventional and complementary medicine, anti-aging technologies, evaluating the effectiveness of alternative medicine, and dietary supplement research and development. He is author of the book Living Longer in the Boomer Age, and co-author of the book Age Wise and is a frequent contributor to national media. He has served as Principal Investigator for 15 controlled clinical studies, three of which were recently published in national peer-reviewed journals, and has presented abstracts at the 11th World Congress for Food Science and Technology and the Federation of American Societies for Experimental Biology.
Nothing to Sneeze At
June 18, 2005 08:41 AM
Author: Darrell Miller
Subject: Nothing to Sneeze At
Nothing to Sneeze At by Carole Poole Energy Times, August 14, 2004
To many, nothing is more annoying than a persistent allergy. Runny nose, itchy eyes, hives, sneezing, coughing...Frequently, allergies seem to represent suffering with no end.
When you are sensitive to something in your environment, often your only hope for relief appears to be to flee to an elsewhere that eludes the problematic, trouble-making allergen.
Complementary measures are available that can lower your risk of allergic reactions. Heading off allergic reactions before they strike can help you enter a comfort zone that leaves nothing to sneeze at.
Limit Your Antibiotics
While people have always suffered allergies, today, many experts agree, allergies are on the rise. One possible explanation: antibiotics. For instance, research at the Henry Ford Hospital in Detroit demonstrates that kids who get antibiotics within six months of being born run an increased risk of being allergic to dust mites, ragweed, grass and animals. At the same time, if two or more cats or dogs live with them, they reduce their chances of allergies (Eur Respir Soc ann conf, 2003).
" I'm not suggesting children shouldn't receive antibiotics. But I believe we need to be more prudent in prescribing them for children at such an early age," Christine Cole Johnson, PhD, says. "In the past, many of them were prescribed unnecessarily, especially for viral infections like colds and the flu when they would have no effect anyway."
Dr. Cole's investigators found that by age 7, kids who got one or more rounds of antibiotics were: • 1.5 times more likely to develop allergies • 2.5 times more likely to develop asthma • Twice as likely to get allergies if their mothers had allergies
When antibiotics are necessary, they are crucial to quelling bacterial infections. However, if you or your children suffer colds or flus, diseases caused by viruses, antibiotics have no effect on your illness but could increase your chance of developing allergies.
" Over the past four decades there has been an explosive increase in allergy and asthma in westernized countries, which correlates with widespread use of antibiotics and alterations in gastrointestinal (GI) microflora," says Mairi Noverr, a researcher on a study linking allergies to antibiotic use (104th Gen Meet Amer Soc Microbiol, 2004). "We propose that the link between antibiotic use and dysregulated pulmonary immunity is through antibiotic-induced long-term alterations in the bacterial and fungal GI microflora." While a lot of research needs to be done, it may help to fortify the probiotic, or good, microbes in your intestines with probiotic supplements. One study has shown that giving probiotics to pregnant women helped their children avoid allergic eczema, a skin condition (Lancet 2001; 357:1076-9).
Green Tea Relief
Research has demonstrated that various types of tea can produce a range of health benefits. Tea drinkers can add allergy relief to that list.
Research in Japan demonstrates that for the allergy-oppressed, green tea may help them have nothing to sneeze at. In laboratory tests, scientist found that green tea contains a substance that blocks one of the immune cell receptors which is often a part of the allergic response. The substance, methylated epigallocatechin gallate (EGCG), is believed to have a similar effect in the real world (J Agr Food Chem 10/9/02).
" Green tea appears to be a promising source for effective anti-allergenic agents," notes Hirofumi Tachibana, PhD, the study's chief investigator and an associate professor at Kyushu University in Fukuoka. "If you have allergies, you should consider drinking it." Traditionally, many people have consumed tea as part of their effort to suppress sneezes, coughs and itchy eyes caused by allergies. This experiment supports the evidence that green tea, in particular, has a reliable effect.
According to Dr. Tachibana, green tea's anti-allergenic benefits have not been completely established, but tea apparently has the potential to be effective against allergens like dust, chemicals, pet dander and pollen.
EGCG has also been shown to be a very active antioxidant, helping to quell the destructive effects of the caustic molecules known as free radicals. Green tea is richer in EGCG than black tea or oolong tea (a type that falls between black and green).
Although other research has demonstrated that EGCG offsets allergic responses in lab animals fed this substance, scientists don't completely understand why it works for allergies. Researchers theorize that EGCG restricts the production of histamine and immunoglobulin E (IgE), two substances secreted in the body as part of the chain of chemical reactions that lead to an allergic reaction, says Dr. Tachibana.
This study shows, for the first time, that a methylated form of EGCG can block the IgE receptor, which is a key receptor involved in an allergic response. The effect was demonstrated using human basophils, which are blood cells that release histamine. As of now, nobody knows how much green tea you need to guzzle to have the best protection against allergies and, of the several varieties available, nobody knows which green tea is best.
Outside of the US, green tea is the second most popular beverage in the world, right behind water. In the US, however, black tea is more popular than green. But the allergy sensitive should think and drink green.
Stay Away from Diesels
Those who are allergic to ragweed or pet dander usually know they should avoid the source of their allergies. But now scientists have found that, for many allergy sufferers, diesel exhaust can also worsen sneezes and wheezes.
Scientists at two southern California schools have shown that about half of us have inherited a sensitivity to diesel pollution that can make our allergies significantly worse (Lancet 1/10/04). "[T]his study suggests a direct way that pollution could be triggering allergies and asthma in a large number of susceptible individuals...," says Frank D. Gilliland, MD, PhD, the study's lead author. Diesel exhaust particles are thought to act as destructive free radicals in the lungs, forming caustic molecules that damage lung tissue. This irritation can cause your immune system to create larger amounts of compounds that make you sneeze and wheeze more.
The Antioxidant Advantage
Antioxidants, scientists believe, can help defuse this damage and ease the body's allergic responses. The California scientists looked at two antioxidant enzymes the body makes to protect the lungs called glutathione S-transferase M1 (GSTM1) and glutathione S-transferase P1 (GSTP1). Only about five of ten people's immune systems can make all the effective forms of these enzymes. The rest of us lack this protection to some degree, and the immune system in about one in five people can't make any effective form of these enzymes.
The research team found that people allergic to ragweed who lacked these antioxidant enzymes suffered more when they took in both ragweed pollen and particles from diesel pollution.
Breathe Easier With C
This research may help explain why many health practitioners recommend vitamin C, a potent antioxidant, to allergy sufferers. Vitamin C "prevents the secretion of histamine by the white blood cells, increases the detoxification of histamine and lowers the blood-histamine levels," says Sylvia Goldfarb, PhD, author of Allergy Relief (Avery/Penguin).
Scientists continue to study the allergy conundrum. Meanwhile, sip a cup of green tea and shut the window before the next truck comes by.
Vision Quest - help fight eye problems.
June 18, 2005 08:34 AM
Author: Darrell Miller
Subject: Vision Quest - help fight eye problems.
Vision Quest by Phyllis D. Light, RH Energy Times, February 11, 2004
Since your eyes are in constant use every day, exposed to the damaging energy of sunlight and pollutants that waft through the air, these delicate orbs are often in danger of wearing out.
To keep this vital part of your anatomy functioning as you age, you have to feed and care for your eyes properly. Otherwise, you are in real danger of losing your vision and independence.
Your vision may be in danger. Experts estimate that 8 million Americans over the age of 55 are at serious risk of blindness linked to a condition called age-related macular degeneration (AMD). AMD can wipe out your central vision and is the primary cause of blindness in Western society.
While AMD causes no pain, it blurs the sharp, central vision necessary for driving, reading and other activities where you need to see either up close or straight ahead. During AMD, the macula, the part of the eye that allows you to pick out fine detail, is destroyed. The macula sits at the center of your retina, the nerve center at the back of your eye that senses light and sends optic signals to the brain.
Age is not the only risk factor for AMD. Scientists have isolated a genetic defect that can lead to some forms of macular degeneration (Nature Genetics 2001; 27:89-93). Smoking and excessive exposure to sunlight are other hazards best avoided if you want to save your sight.
In many cases, AMD progresses so slowly that victims of this condition don't even notice that their vision is deteriorating until much of it is irrevocably gone.
Dry and Wet AMD
Wet AMD occurs when blood vessels in back of the retina start to overgrow and leak blood. As this occurs, blood and other fluids push on the macula and quickly damage its sensitive nerve endings. When wet AMD occurs, you lose your central vision rapidly. If straight lines appear wavy to you, you may be suffering from wet AMD. If you notice this or other unusual vision changes, contact an eye care specialist as soon as possible. You need what is called a comprehensive dilated eye exam that can uncover signs of AMD.
Dry AMD strikes the eye when light-sensitive cells in the macula slowly deteriorate, gradually blurring central vision in the affected eye. As dry AMD progresses, a blurry spot in the center of your vision may appear. Eventually, as more of the macula becomes dysfunctional, the central vision in the eye can gradually disappear.
The most common sign of dry AMD is slightly blurry vision. This can make it hard to recognize faces and also make it harder to read without very bright light. Dry AMD generally attacks both eyes, but vision can be lost in one eye while the other eye stays normal. In the early stages of dry AMD, drusen, yellow deposits that gather under the retina, may form. Dry AMD progresses in three stages:
• Early AMD: Small drusen form but vision is unaffected. • Intermediate AMD: Many medium drusen appear or, alternately, one large drusen occurs. Center vision is often blurred and reading requires bright lights. • Advanced Dry AMD: Drusen formation is accompanied by deterioration of tissue in the macula. Blurs in central vision expand, eventually destroying most vision. Note: Because of the fast destruction it causes, wet AMD is an advanced form of this disorder that is considered more severe than the dry version.
Vitamins and Minerals for AMD
Fortunately, scientists have found ways to combat AMD: An analysis of a study called the national Age-Related Eye Disease Study (AREDS) shows that more than 300,000 Americans could avoid losing their sight to AMD if they took daily supplements of antioxidant nutrients and zinc.
This conclusion, reached by scientists at Johns Hopkins' Wilmer Eye Institute, is based on research involving more than 4,500 adults suffering various stages of AMD. The study demonstrated that people who already had some AMD could lower their risk of the more advanced form of this condition by 25% when they took vitamin C, natural vitamin E and beta carotene along with zinc. Those suffering from advanced AMD lowered their chances of losing vision by about 19%. (Supplements did not affect the risk of cataracts or the chances of some vision loss for people in the early stages of AMD.)
" Without treatment to reduce their risk, we estimate that 1.3 million adults would develop the advanced stage of AMD," says Neil M. Bressler, MD, professor of ophthalmology at Johns Hopkins and author of the current study, published in Archives of Ophthalmology (11/03).
According to Dr. Bressler and the other researchers, people who now have intermediate AMD (some vision loss) in one eye have about a 1 in 16 chance of having their vision deteriorate until they have advanced AMD. They also calculate that about 1 in 4 of those with intermediate AMD in both eyes and 43% of those with advanced AMD in one eye will develop advanced AMD in five years without treatment.
In their view, older people at risk of AMD blindness should take daily supplements of 500 milligrams of vitamin C, 400 milligrams of natural vitamin E, 15 milligrams of beta carotene, 80 milligrams of zinc as zinc oxide and 2 milligrams of copper as cupric oxide. Evidence also exists that a diet which is high in fat can cause AMD to progress to an advanced stage. The exceptions: The healthy fats found in fish and nuts (Archives of Ophthalmology 2003; 121:1728-37).
Oddly enough, some of the same pigments that color vegetables and other foods also color your eyes. And scientists believe that those pigments, which are classified as carotenoids, help protect the eyes by helping them fight off the negative effects of caustic molecules called free radicals. Free radicals are formed when the energy from sunlight strikes the eyes and disrupts the composition of natural chemicals found there.
When scientists compared healthy eyes with eyes suffering from AMD, they found that AMD eyes contained lower levels of lutein and zeaxanthin, carotenoid pigments contained in egg yolk, spinach, broccoli and other dark green vegetables (Ophthalmology 2003; 109:1780). Furthermore, they found that levels of these chemicals generally decline as you grow older.
" This research is a major step toward large-scale clinical studies to prove the extent to which lutein and zeaxanthin protect against age-related macular degeneration," says Paul S. Bernstein, MD, PhD, at the University of Utah School of Medicine at Salt Lake. "We know that these carotenoids are specifically concentrated in the macula of the human eye."
Dr. Bernstein adds that, as you age, taking supplements containing lutein and other antioxidants may lower your AMD risk. In his investigation, people with AMD who did not take lutein had one-third less lutein in their eyes than older people whose vision was normal.
Another eyesight hazard is cataracts, in which the eye's lens-the part that focuses incoming light onto the retina-becomes cloudy. Cataracts form when the proteins found in the normally clear lens become damaged; signs include progressively blurred vision (especially outdoors), focusing problems, seeing streaks of light from headlights and stoplights, and colors that look faded.
Cataract is the leading cause of blindness worldwide, according to the World Health Organization. One of every six Americans 40 and older suffers from some degree of cataract; it affects half of all Americans who reach age 80. Nuclear cataracts, the most common form of this disorder, develop in the center of the lens and tend to grow slowly. Cataracts may also develop at the back of the lens; this form is linked to eye trauma and long-term use of certain medications, including steroids.
Like AMD, cataracts become more common as people age. Up to 40% of individuals between the ages of 75 and 85 have them, compared with only 5% to 10% of those folks under the age of 65. And like AMD, sunlight exposure and smoking increase the risk of developing cataracts, as does the presence of diabetes.
Lutein and zeaxanthin, the carotenoids that are so plentiful in the macula, are also found in the lens (although in lower concentrations), leading many researchers to believe that these nutrients may help drop your risk of cataract development. Early studies indicate that an increased intake of lutein and zeaxanthin reduces one's chances of needing cataract surgery, the most common surgery in the United States (American Journal of Clinical Nutrition 1999; 70(4):509-16; 517-24).
Antioxidants and the Lens
Scientists believe that free-radical damage is a leading cause of cataracts, and so it isn't surprising that antioxidants have proved useful in preventing this problem.
Almost 500 women filled out diet questionnaires as part of a very large research effort called the Nurses' Health Study; those who had taken vitamin C supplements for 10 years or longer enjoyed the lowest rates of nuclear cataracts (Archives of Ophthalmology 2001; 119:1009-19).
So the answer to lowering your risk of eye problems is clear, whether you are already in your mature years or plan to be someday: Lead a healthy, eye-friendly lifestyle, eating a diet filled with colorful fruits and vegetables. Take frequent walks and jogs around the block.
And yes, when you kick back and take your just-as-frequent doses of antioxidant supplements, you're allowed to take your sunglasses off and see the world clearly.
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Bromelain Sinus Ease - Nature's Life
June 16, 2005 10:57 AM
Author: Darrell Miller
Subject: Bromelain Sinus Ease - Nature's Life
Bromelain Sinus Ease™
Nature's Life Sinus Products:
Sinus cavities are lined with delicate mucous membranes, which act as filters for your respiratory system. Normal sinuse tissues are pink and healthy. For many people, when their sinuses come in contact with allergens, pollutants or harmful micro-organisms, histamines are released as a protective measure by the immune system. Sinuses naturally respond by becoming irritated, red, and inflamed with these healing histamines. This process, called the natural inflammatory response, helps to neutralize and remove the irritants in sinuses cavities. Sometimes, however, the immune system continues to flood the sinuses even after the irritants are removed. Bromelain Sinus Ease™ contains three ingredients that have been shown to enhance the body’s ability to reduce this natural inflammatory response and help clear up sinuses.*
Bromelain is a group of protein-digesting enzymes extracted from pineapples (Ananassa sativa). Bromelain breaks down fibrin—a key component of the body’s natural inflammatory response to allergens and other foreign stimuli.* Bromelain also appears to inhibit the natural formation of prostaglandins (hormone-like substances) that trigger the natural inflammatory response.*1 It makes mucus less thick,2 allowing the mucus to drain more easily.*
Human trials have shown that by breaking down and helping to remove fibrin, bromelain reduces the discomfort of irritated tissues.*3 Double-blinded trials in patients with irritated sinuses show that the natural inflammatory response is reduced more effectively by concentrated bromelain than by placebo.*4 ,5 ,6 ,7 In all cases, a majority of people responded well to bromelain supplements.*
Bromelain has also helped reduce the duration of the natural inflammatory response after nasal procedures by over 70% in a controlled trial.*8
The recommended daily amount of Nature’s Life Sinus Ease™ utilizes 1,200 mg a very high potency bromelain enzyme which has an activity of 2,880 GDU (Gelatin Digestive Units), or 4,320 MCU (Milk Clotting Units) per serving.
Vitamin C also helps reduce histamine release.*9 Some studies have reported that vitamin C is useful in reducing the natural inflammatory response in nasal passages.*10, 11, 12 The effectiveness of vitamin C in reducing histamine release is still debated, however, because a controlled trial was unable to show consistent effects.*13 Doses up to 2 grams per day have been used by researchers. It may be difficult to show these effects in research trials because vitamin C appears to help only some people without affecting others.*14 Studies, however, clearly show that vitamin C supplementation can lower elevated blood levels of histamines.*15, 16 Nature’s Life adds naturally-buffered vitamin C to Sinus Ease due to its safety, immune-supporting effects and potential efficacy to reduce histamine release.*
Quercetin is a bioflavonoid found in many natural foods including citrus fruits, onions, apples, tea and lettuce. As with bromelain, quercetin helps reduce the natural inflammatory response by inhibiting the natural formation of the pro-inflammatory agents, prostaglandins and leukotrienes (white blood cells).*17,18 Quercetin also helps lessen the natural inflammatory response for children with sensitivities to inhalants.*19 Additionally, quercetin may help reduce the effects of harmful micro-organisms *20 Bioflavonoids at doses of 1,200 mg per day have reduced the natural inflammatory response in human studies in combination with 1,200 mg vitamin C,21 an outcome confirmed in double-blinded research using 600 mg/day of bioflavonoids and 450 mg/day of vitamin C.*22
Substances which inhibit the natural inflammatory response rarely target just one part of the body.* While quercetin has yet to be tested in reducing the natural inflammatory response in sinuses specifically, doctors of natural medicine frequently use it for that purpose because of its proven ability to lessen the natural inflammatory response elsewhere in the body.*
Nature’s Life Sinus Ease™
Nature’s Life has combined these powerful phytonutrients to make Sinus Ease™. High potency Bromelain, Quercetin and vitamin C work to inhibit the natural pro-inflammatory response and encourage adequate sinus drainage.* No safety concerns have been identified with any of these ingredients.23, 24 It is recommended to take the three capsules per day between meals. Since bromelain is a proteolytic enzyme, if taken with a meal it will act on the protein in the food rather than the natural pro-inflammatory fibrin, so remember to take it between meals.* Enjoy the winter season and find relief from allergens throughout the year! Nature’s Life Sinus Ease™ can help.
Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypoth 1980;6:99-104.
Martin GJ. Bromelain pineapple proteases with anti-edema activity. Exper Med Surg 1962;20:228-48.
Blonstein JL. Control of swelling in boxing injuries. Practitioner 1969;203:206.
Seltzer AP. Adjunctive use of bromelains in sinusitis: a controlled study. EENT Monthly 1967;46:1281-8.
Taub SJ. The use of Ananase in sinusitis—a study of 60 patients. EENT Monthly 1966;45:96-8.
Ryan RE. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7:13-7.
Taub SJ. The use of bromelains in sinusitis: a double-blind clinical evaluation. EENT Monthly 1967;46:361-5.
Seltzer AP. Minimizing post-operative edema and ecchymoses by the use of an oral enzyme preparation (bromelain). EENT Monthly 1962;41:813-7.
Johnson CS, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr 1992;11:172-6.
Zuskin E, Lewis AJ, Bouhuys A. Inhibition of histamine-induced airways constriction by ascorbic acid. J Allergy Clin Immunol 1973;51:218.
Ruskin SL. High dose vitamin C in allergy. Am J Dig Dis 1945;12:281.
Holmes HN. Hay fever and vitamin C. Science 1942;96;497.
Fortner BR, Danziger RE, Rabinowitz PS, Nelson HS. The effect of ascorbic acid on cutaneous and nasal response to histamine and allergen. J Allergy Clin Immunol 1982;69:484-8.
Bai TR, Martin JG. Effects of indomethacin and ascorbic acid on histamine induced bronchoconstriction in normal subjects. NZ Med J 1986;99:163 [abstr].
Holmes H, Alexander W. Hay Fever and Vitamin C. Science 1942;96:497-99.
Johnston CS, Martin LJ, Xi C. Antihistamine Effect of Supplemental Ascorbic Acid and Neutrophil Chemotaxis. J Am Coll Nutr 1992;11:172-6.
Middleton E, Drzewieki G. Naturally occurring flavonoids and human basophil histamine release. Arch Allergy Applied Immunol 1985;77:155-7.
Welton AF, Tobias LD, Fiedler-Nagy C, et al. Effect of flavonoids on arachidonic acid metabolism. Prog Clin BiolRes 1986;213:231-42
Balabokin II, Gordeeva GF, Fuseva ED, et al. Use of vitamins in allergic illnesses in children. Vopr Med Khim (Russia) 1992;38:36-40.
Ohnishi E, Bannai H. Quercetin potentiates TNF-induced antiviral activity. Antiviral Res 1993;22:327-31.
Miller MJ. Injuries to athletes. Med Times 1960;88:313-6.
Cragin RB. The use of bioflavonoids in the prevention and treatment of athletic injuries. Med Times 1962;529-32.
Taussig SJ, Yokoyama MM, Chinen N, et al. Bromelain: A proteolytic enzyme and its clinical application. Hiroshima J Med Sci 1975;24:185-193.
Hertog MGL, Feskens EJM, Holman PCH, et al. Dietary flavonoids and cancer risk in the Zutphen elderly study. Nutr Cancer 1994;22:175-84.
June 14, 2005 06:11 PM
Author: Darrell Miller
Subject: Green Power
by Charles Scott Energy Times, January 4, 2005
If you want to stave off infections, aging-even liver cancer-get your fill of chlorophyll, a vital nutrient in plants.
The green in plants possesses unique powers. Green landscapes soothe the soul. A verdant expanse of green vegetation offers comfort, peace and ecological consolation. What makes some plants, including vegetables, green: Chlorophyll, a substance that is also a crucial nutrient for better health.
Chlorophyll is a special chemical that consists of molecules which enable plants to collect sunlight. In a complex molecular process, vegetation then uses chlorophyll to harness the power from the sun's rays and build carbohydrates from carbon dioxide and water. Those carbohydrates form the basic nutritional building blocks that we and other animals need to survive and thrive.
Besides enabling the creation of carbohydrates, research shows that chlorophyll itself can help lower our risk of diseases like cancer. A recent study in China demonstrates that daily supplements of a chemical derived from chlorophyll can protect DNA, the genetic material in cells. When DNA is damaged and malfunctions, cells may reproduce wildly and become cancerous tumors. The latest experiments, performed by scientists affiliated with the Johns Hopkins Bloomberg School of Public Health and Oregon State University (OSU), show that chlorophyll and its chemical relatives may insulate DNA from unhealthy changes linked to aflatoxin, a fungus that often contaminates corn, peanuts and soybeans. In China, liver cancer associated with aflatoxin is a widespread problem.
" In the area of China in which we did our study about one in 10 adults die from liver cancer, and it's the third leading cause of cancer deaths worldwide," says George Bailey, PhD, a professor of environmental and molecular toxicology at OSU. "The findings of this research could be enormously important to many areas of China, Southeast Asia and Africa, where aflatoxin-related liver cancer is a real concern. Many of these deaths might be preventable with supplements that cost pennies a day."
This research looked at about 180 people in Qidong, China. When people in the study were given supplements containing chlorophyll derivatives, they had less than half the DNA damage of people who didn't take supplements.
According to the scientists, chlorophyll and similar substances may act as interceptor molecules, blocking the absorption of carcinogens. As John Groopman, professor at the Johns Hopkins School of Public Health, observes, the supplements these people took "...can effectively reduce aflatoxin levels, which should reduce the risk of liver cancer."
Closer to home, other researchers point out that chlorophyll-rich vegetarian foods may help protect us from carcinogens in the typical American diet.
If you've ever enjoyed a hunk of grilled meat, you've consumed substances scientists call heterocyclic amines, which are contained in the charred part of meat cooked on a grill. Studies have shown that these tasty tidbits can increase your risk of breast and other types of cancer. (Your risk from charred meat greatly increases if you are also a smoker.) However, if you eat a food like spirulina, a blue-green algae high in antioxidants that also contains plenty of chlorophyll, its protective substances can bind with these carcinogens within your digestive tract and keep them from being absorbed.
Green Keeps You Younger
While we always hear that eating more fruits and vegetables enhances our health, new research shows that eating green foods adds extra power to an anti-aging program.
Two experiments at the University of South Florida Center for Aging and Brain Repair, published in the Journal of Neurobiology (7/15/02), show that spirulina and other greens can help shield the brain from the antioxidant damage that accumulates as one ages and may help reverse declines in learning and memory.
The first study found that a diet rich in spinach helped lab animals stay smart as they grew older. Spinach's benefits, according to the researchers, are due to its rich antioxidant content, which can counteract free radicals (caustic molecules) created in the body during normal metabolism and increased by exposure to environmental pollutants, sunlight and radiation. When free radicals attack, cell walls and other cellular structures are compromised and DNA can malfunction. A lifetime of free-radical damage can slow your thinking and may be one of the causes of Alzheimer's and Parkinson's diseases, says Dr. Paula Bickford, lead author on the project.
The second study found that the protective effect of green plants may be linked to their ability to reverse age-related accumulations of potentially harmful inflammatory substances in the brain. In this research, spirulina improved neuron function, lowered inflammation in the brain and reduced levels of chemicals linked to oxidative damage. In fact, spirulina didn't just slow the deterioration of neurotransmitter interactions caused by aging, it actually improved their function.
" Not all foods are created equal," says Dr. Bickford. "Cucumbers taste good and have lots of fiber. But unlike spirulina and apples, they are not rich in phytochemicals that have antioxidant or anti-inflammatory effects in the brain."
Aside from assisting brain function, spirulina also seems able to help pump up the immune system. Researchers at the University of California at Davis found that adding spirulina to cultured immune system cells significantly increases the production of infection-fighting cells called cytokines.
A number of previous laboratory studies have found that spirulina can balance immune response: While easing allergic reactions, this powerful green food also was found to enhance the ability of immune cells called macrophages to both destroy bacteria and eliminate cancerous cells.
" We found that nutrient-rich spirulina is a potent inducer of interferon-g (13.6-fold increase) and a moderate stimulator of both interleukin-4 and interleukin-1b (3.3-fold increase)," notes Eric Gershwin, professor at UC Davis. "Together, increases in these cytokines suggest that spirulina is a strong proponent for protecting against intracellular pathogens and parasites, and can potentially increase the expression of agents that stimulate inflammation, which also helps to protect the body against infectious and potentially harmful micro-organisms."
What this means for you: Spirulina holds the potential to help the body protect itself against battalions of infectious invaders. " People have used foods like yogurt and spirulina throughout history," says Judy van de Water, PhD, associate professor at UC Davis. "Through research, we are learning exactly how these foods improve immune system function and how they are a beneficial addition to our diet."
Throughout the history of life on earth, the healthy development of animal and human life has depended on green plants. Today, as our environment deteriorates and our bodies are under attack from an increasingly polluted world, we need those health-boosting greens more than ever.
Cancer fighter is found in broccoli
June 14, 2005 06:09 PM
Author: Darrell Miller
Subject: Cancer fighter is found in broccoli
Cancer fighter is found in broccoli
WASHINGTON (AP) - Remember when your mother told you to eat broccoli? Scientists say they've proved mother knows best.
Dr. Paul Talalay of Johns Hopkins University School of Medicine said in a paper published today that studies in his lab show broccoli is rich in sulforaphane, a chemical that works as a powerful anti-cancer compound in laboratory mice. Studies have shown that a diet rich in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower, can lower the risk of cancer of the bowel, stomach and breast. How those vegetables caused the effect wasn't clear.
Now, Dr. Talalay said, it appears that at least one anti-cancer ingredient in the vegetables is sulforaphane. It works by causing cells to expel cancer-causing toxins. He said this is the first time a high-potency compound has been isolated from vegetables and has been shown to accelerate the detoxification process in cells. Dr. Talalay said his team isolated sulforaphane from broccoli, then fed it to a group of mice. When cells in the mice were examined after five days, the scientists found that the chemical had triggered enzymes known to neutralize carcinogens within cells. Research, Dr. Talalay said, will shift to the long-term cancer-fighting effects of the chemical. "Our prediction is that sulforaphane will block tumor formation in animals and presumably in man," he said. Nutrition and medical scientists are trying to find ways to prevent cancer through a diet rich in foods that have anti-tumor properties.
In earlier studies, Dr.Talalay said, he and others have shown that certain proteins in cells, called Phase I enzymes, can take innocent chemicals and turn them into carcinogens, or compounds that can give rise to cancer by disrupting the genetic pattern in cells. Other proteins, called Phase 2 enzymes, he said, tend to block formation of carcinogens. Sulforaphane, he said, is a potent activator of Phase 2 enzymes. "There is mounting evidence that if you are able to raise the Phase 2 enzymes, this will divert the carcinogenic compounds from damaging the [genes]," Dr. Talalay said. "By tilting this balance toward Phase 2 enzymes, we can achieve protection from cancer." The Hopkins researchers will conduct tests to determine how much broccoli must be consumed to establish an effective anti-cancer level of sulforaphane in cells. Over a decade of research has been done on cruciferous vegetables and there are large databases that confirm that cruciferous vegetables substantially reduce the risk of disease, specifically cancer. Studies show substances in these vegetables that have anti-cancer properties which cause the body to speed up production of enzymes, therefore being capable of neutralizing cancer agents. The studies also show these prevent damage to our DNA and slow the aging process. In women, metabolic processes are regulated which eliminate the bad (and maintain the good) estrogen, therefore substantially reduce the risk of breast cancer. Shortly after the NCI study was released, John Hopkins School of Medicine revealed similar studies.
Due to these study results, the National Cancer Institute, the American Cancer Society, the National Academy of Sciences, the U.S. Department of Agriculture, John Hopkins School of Medicine and the FDA have all reached out to inform the public of the anti-cancer compounds found in cruciferous vegetables, and are advocating the daily consumption of these vegetables. The average American has been eating only 4 and one half pounds of these vegetables per year!
The A Team
June 14, 2005 06:04 PM
Author: Darrell Miller
Subject: The A Team
The A Team
by Gregory Meade Energy Times, October 11, 2004
Want the A Team playing to improve your health? When you accumulate enough antioxidants to help you attack the molecular marauders out to mar your well-being, you improve your chances of avoiding illness.
Nowadays you hear plenty of talk about the benefits of antioxidant nutrients. Antioxidants are the ammunition the body uses to fight off internal damage. They offer the body the means to fight against disease but, at the same time, your body must be in the position to use them optimally. That means getting enough sleep, consistently exercising and avoiding overly processed foods. Those lifestyle habits allow your body to garner its resources and effectively implement antioxidants in its quest for well-being.
Your body has a love-hate relationship with oxidation: Can't live without it, often has trouble living with it. For instance, the production of energy in your cells requires oxidation. But the byproducts of that process, problematic molecules called free radicals, have to be chemically changed or eliminated to avoid the damage that results when they interact with other parts of the cell. Left unchecked, these molecular troublemakers can wreak havoc, oxidizing and punching holes in cell membranes and damaging other structures they contact. Antioxidant nutrients are used to defend against oxidation, quell these harmful destroyers and limit the potential harm they can cause.
For a quick glimpse of one of your basic antioxidant defenses, look in the mirror. The color in your eyes represents antioxidant protection against oxidative injury from the ultraviolet rays in sunlight. Sunlight's energy sets loose free radicals every time it enters the lenses in your eyes. Pigments absorb this radiation and, in most cases, render it harmless.
As part of your vision's defenses, two of the antioxidant pigments in your food, lutein and zeaxanthin, are deposited by your body in certain areas of your eyes-in a section called the macula as well as the lens (BJ Opthalmol 1998; 82:907-10).
Lutein and zeaxanthin are classified as carotenoids, chemical relatives of beta carotene, the antioxidant pigment that makes carrots orange, and lycopene, the anticancer red coloring found in tomatoes. These fat-soluble nutrients are also present in algae. In both your eyes and plants, these nutrients absorb the destructive ultraviolet rays that give birth to free radicals.
Studies show that consuming large amounts of these pigments lowers your risk of a common form of blindness called age-related macular degeneration (ARMD) and drops your chances of age-related cataracts. (More than 30 million people worldwide suffer from ARMD, and cataracts is the leading cause of blindness across the globe.)
When the sun's rays enter the eye, lutein and zeaxanthin absorb and filter out dangerous radiation before it can injure the macula. The macula is the central part of the retina that allows us to see very fine detail. Otherwise, over time, as the macula deteriorates, our vision worsens. In addition, some researchers believe these nutrients help lower your chances of cancer.
Lutein and zeaxanthin are found in spinach, Brussels sprouts, corn, collard greens, green beans, egg yolks, broccoli, cabbage, kale, lettuce, kiwi and honeydew melons. The petals of yellow flowers like marigolds and nettles are also rich in these antioxidant nutrients.
You can also increase your chances of better sight as you age by consuming sulphoraphane, an antioxidant found in broccoli. Researchers at Johns Hopkins University have found that sulphoraphane takes part in the body's efforts to shield eye cells from free radicals generated by ultraviolet light (Proc Natl Acad Sci 2004; 101(28):10446-51).
The researchers who performed this study believe that unlike the antioxidant nutrients vitamin C and natural vitamin E, sulphoraphane acts as an "indirect" antioxidant. That means that while those two vitamins are used by the body to directly defuse the harmful oxidative force of free radicals (and then must be replaced or regenerated in the cells), sulphoraphane acts indirectly, boosting the body's immunity defenses. Because of that indirect action, researchers point out, sulphoraphane lasts longer in the body and may produce a more profound, long-term antioxidant effect.
In other laboratory tests, researchers have discovered that sulphoraphane can kill Helicobacter pylori, a bacterium recognized 20 years ago as the cause of debilitating stomach ulcers and often-fatal stomach cancers (Proc Natl Acad of Sci 5/28/02). This research shows that sulphoraphane is even effective against antibiotic-resistant Helicobacter. Adding to its benefits, sulphoraphane can help kill bacteria both inside and outside stomach cells; when this bacteria hides inside of cells it is particularly difficult to fight.
" We've known for some time that sulforaphane had modest antibiotic activity," says Jed Fahey, a plant physiologist at Hopkins. "However, its potency against Helicobacter, even those strains resistant to conventional antibiotics, was a pleasant surprise."
Looking for Mr. Good Diet
For the biggest bang for your antioxidant buck, combine antioxidants with good lifestyle habits. A laboratory study of the heart-healthy effects of taking supplements of the antioxidant vitamins C and natural E along with L-arginine (an amino acid) found that exercise magnifies benefits (Proceedings of the National Academy of Sciences 5/24/04, online). The scientists who performed this study recommend exercise along with antioxidants to boost your nutritional advantage.
The box score shows that when playing with the A Team you've got the best chance of hitting an antioxidant home run.
America's Most Wanted
June 14, 2005 05:23 PM
Author: Darrell Miller
Subject: America's Most Wanted
America's Most Wanted
by Brian Amherst Energy Times, January 6, 2000
The United States eats well, a little too well, according to experts. Amply supplied with a large supply of high-calorie food, our diets might seem to be chock full of every conceivable nutrient. Well, to the question "Getting all the right vitamins, minerals and other nutrients?" the most appropriate answer seems to be "Not exactly." Eating a lot doesn't equal eating a lot of the most important vitamins and minerals. So, which vitamins and minerals are likely to show up in short supply in the typical American diet? Calcium certainly sits at the top of list. According to the most recent Continuing Survey of Food Intake by Individuals, which is conducted by the United States Department of Agriculture (USDA), women and girls age 12 and up are not consuming adequate calcium from their diet. Research reveals that about 1200 mg. day suffices for those over age 50 and 1000 mg a day should be adequate if you're between the ages of 19 and 50. Since strong bones are formed during "the first three decades of life," says Laura Bachrach, MD, of Since strong bones are formed during "the first three decades of life," says Laura Bachrach, MD, of Stanford University, ". . .osteoporosis is a pediatric disease." For long-range protection against that bone-weakening disease, kids should eat calcium-rich, low-fat dairy products and plenty of leafy greens (broccoli, cabbage, kale) as well as salmon (with bones), seafood and soy. But the calcium campaign does not end in early adulthood. Bone mass begins to deteriorate at about age 30. Menopausal hormonal changes can exacerbate bone brittleness. Medical conditions, including cancer, liver disease and intestinal disorders; prescription drugs; tobacco and alcohol indulgence; or a decline in activity, especially the weight-bearing kind, also jeopardize bone strength. According to the National Osteoporosis Foundation, about one in every two American women will break a bone after age 50 due to osteoporosis. That translates into about half a million fractured vertebrae and more than 300,000 shattered hips. Frequently, those breaks are life-threatening.
The critical role of calcium in many body functions is perhaps the most extensively clinically documented among nutrients. Researchers in the Department of Medicine, Oregon Health Sciences University in Portland, reviewed epidemiological and clinical studies conducted over the past two years on the relationship between dietary calcium and blood pressure (J Am Coll Nutr October 1999: 398S-405S). "Nearly 20 years of investigation in this area has culminated in remarkable and compelling agreement in the data," the researchers report, "confirming the need for and benefit of regular consumption of the recommended daily levels of dietary calcium." Investigators at the State University of New York, Buffalo School of Dental Medicine, presented results of their studies of calcium and vitamin C and gum disease at the June 26, 1998 meeting of the International Association for Dental Research. Two separate inquiries revealed that people who consumed too little calcium as young adults, and those with low levels of vitamin C in their diets, appear to have nearly twice the risk of developing periodontal disease later in life than folks with higher dietary levels of either nutrient.
Calcium: Much Documented Researchers offer extensive evidence of calcium's benefits on many fronts: n Osteoporosis poses a threat to older men as well as women, according to Randi L. Wolf, PhD, research associate at the University of Pittsburgh Graduate School of Public Health. Dr. Wolf presented her award-winning study to an October 3, 1999 meeting of the American Society for Bone and Mineral Research. Dr. Wolf suggests that men increase their consumption of calcium, particularly after age 80, to avoid age-related declines in the amount of calcium absorbed. According to Dr. Wolf, "It appears that the hormonal form of vitamin D, which is the main regulator of intestinal calcium absorption, may have an important role. We are conducting more research to better understand the reasons for why calcium absorption declines with age in men." n Scientists at Tufts University in Boston did some earlier work on the calcium-vitamin D connection and reported it in the September 4, 1997 New England Journal of Medicine. Using the National Academy of Sciences (NAS) increased recommended daily intake of 1200 milligrams of calcium and 400 to 600 international units of vitamin D for people over 50, the Tufts researchers found that with supplementation of the nutrients, men and women 65 and older lost significantly less body bone and, in some cases, gained bone mineral density. n Two studies published in American Heart Association journals show that atherosclerosis and osteoporosis may be linked by a common problem in the way the body uses calcium. The September 1997 Stroke revealed that, in a group of 30 postmenopausal women 67 to 85 years old, bone mineral density declined as atherosclerotic plaque increased. Researchers reporting in Circulation (September 15, 1997) advanced the theory that the osteoporosis-atherosclerosis connection may be related to a problem in handling calcium. n For people who had colon polyps removed, taking calcium supplements decreased the number of new polyps by 24% and cut the risk of recurrence by 19%, according to researchers at the University of North Carolina, Chapel Hill, School of Medicine. The study, published in the January 14, 1999 New England Journal of Medicine, was a first in crediting calcium with anti-cancer properties.
The D Factor
Without adequate vitamin D, your absorption of calcium slips and bone loss can accelerate, increasing the risk for fractures. Fifty percent of women with osteoporosis hospitalized for hip fractures at Brigham and Women's Hospital in Boston had a previously undetected vitamin D deficiency (Journal of the American Medical Association, April 28, 1999). University of Pittsburgh Cancer Institute researchers told participants at the April 14, 1997 meeting of the American Association for Cancer Research that vitamin D "significantly inhibits highly metastatic, or widespread, prostate cancer in animals," suggesting its potential for treating men with similar conditions. Few foods that Americans eat, except dairy, contain much vitamin D, but we can usually synthesize sufficient amounts from as few as five minutes' exposure to the sun. But as skin ages, its ability to act as a vitamin D factory decreases. According to Michael F. Holick, the director of the Vitamin D, Skin and Bone Research Laboratory at Boston University Medical Center, upwards of 40% of the adult population over age 50 that he sees in his clinic are deficient in vitamin D. Recently, the National Academy of Sciences (the official body that decrees the required amounts of necessary nutrients) increased the daily recommendations of vitamin D to 600 IU for people over 71, 400 IU for those aged 51 to 70 and 200 IU for people under 50. The best dietary sources, apart from dependable supplements, are dairy and fatty fish like salmon. Four ounces of salmon provide about 300 IU.
The Facts About Fats
The American lust for low-fat, high-carbohydrate diets filled with sugary foods has exploded into nothing short of "obsession," according to experts at the General Research Center at Stanford University Medical Center (Am J Clin Nutr 70, 1999: 512S-5S). That mania oftens robs us of the crucial balance of omega-3 and omega-6 fatty acids typical of the Mediterranean diet that protect us from heart disease by controlling cholesterol and making blood less likely to form clots. These fatty acids cannot be made by the body but are critical for health: n Omega-3 fatty acid (linolenic acid) comes from fresh, deepwater fish (salmon, mackerel, sardines) and vegetable oils such as canola, flaxseed and walnut. n Omega-6 fatty acid (linoleic acid) found primarily in raw nuts, seeds and legumes and in saturated vegetable oils such as borage, grape seed, primrose, sesame and soybean. The American Heart Association recommends limiting total fat consumption to 30% of daily calories. Saturated fats like those in dairy and meat products as well as vegetable oil should comprise 10% of total calories; total unsaturated fat (fish oils, soybean, safflower nuts and nut oils) should be restricted to 20 to 22% of daily calories.
Be Sure About B12
Vitamin B12 presents a particular problem for the elderly because older digestive systems often don't secrete enough stomach acid to liberate this nutrient from food. (The elderly have no problem absorbing B12 from supplements, because it's not bound to food.) Vitamins generally moderate the aging process but, ironically, that process and the diseases that frequently accompany it affect vitamin metabolism (Schweiz Rundsch Med Prax 83, 1994: 262-6). And because of those changes, we need more of certain vitamins. This is the case for vitamins D, B6, riboflavin and B12. Crucial for health, B12 is necessary to prevent anemia, and, according to recent studies, needed (along with folate and B6) to help stave off heart disease. B12, with thiamine and niacin, boosts cognition (Adv Nutr Res 7, 1985: 71-100). Screening for vitamin B12 deficiency and thyroid disease is cheap and easy and can prevent conditions such as dementia, depression or irreversible tissue damage (Lakartidningen 94, 1997: 4329-32). In the January 5-12, 1999 issue of Circulation: Journal of the American Heart Association, the AHA urged doctors to screen levels of homocysteine (the amino acid byproduct of protein digestion that damages arteries, causes heart disease and, possibly, strokes) in patients at high risk for heart disease. They also recommended all Americans to up their daily levels of vitamins B6 and B12, as well as folic acid. Since fruits, vegetables or grains lack B12, vegetarians need B12 supplements. And they're a good idea for the rest of us, too.
Folic Acid Benefits
Folic acid made headlines in the early 1990s when the U.S. Public Health Service declared that "to reduce the frequency of neural tube defects [spina bifida, or open spine, and anencephaly, a lethal defect of the brain and skull] and their resulting disability, all women of childbearing age in the United States who are capable of becoming pregnant should consume .4 milligrams (400 micrograms) of folic acid per day." This recommendation followed voluminous research that showed taking folic acid was associated with a significantly reduced risk of birth defects. (The advisory is based on the fact that nearly half of all pregnancies are unplanned. If you think you are pregnant, consult your health practitioner for supplementary advice.)
A Team Player
Folic acid's efficacy intensifies when it works with other nutrients. Among many studies on the preventive powers of folic acid on birth defects, one published in The New England Journal of Medicine (327, Dec. 24, 1992: 1,832-1,835), disclosed an even greater decrease in neural tube defects when supplements of folic acid contained copper, manganese, zinc and vitamin C. As a warrior against homocysteine, folic acid joins the battalion of B12 and B6 in detoxifying this harmful protein. At the University of Washington's Northwest Prevention Effectiveness Center, researchers recently analyzed 38 published studies of the relationship between folic acid, homocysteine and cardiovascular disease and, according to associate professor Shirley A. Beresford, MD, folic acid and vitamin B12 and B6 deficiencies can lead to a buildup of homocysteine.
Canadian researchers reported in the Journal of the American Medical Association (275, 1996: 1893-1896) that men and women with low folic acid have a 69% increase in the risk of fatal coronary heart disease. This 15-year study of more than 5,000 people stressed the need for dietary supplementation of folic acid. Folic acid also has been credited with the potential to protect against cancers of the lungs, colon and cervix. It appears to help reverse cervical dysplasia, the precursor cells to cervical cancer, especially for women taking oral contraceptives, which may cause a localized deficiency of folic acid in the cells of the cervix. According to Shari Lieberman, PhD, and Nancy Bruning, authors of The Real Vitamin & Mineral Book (Avery), folic acid derivatives work with neurotransmitters, the chemicals that permit signals to be sent from nerve fiber to nerve fiber. A lack of folic acid can cause some nervous-system disorders, such as depression, schizophrenia and dementia; it also may be related to some forms of mental retardation. Other supporting roles of folic acid, according to researchers: the formation of normal red blood cells, important for preventing the type of anemia characterized by oversized red blood cells; strengthening and improving white blood cell action against disease; limiting production of uric acid, the cause of gout.
The Best Sources
Many foods are rich in folic acid: beef, lamb, pork and chicken liver, spinach, kale and beet greens, asparagus, broccoli, whole wheat and brewer's yeast. But experts believe that only 25 to 50% of the folic acid in food is bioavailable. Processing also reduces an estimated 50 to 90% of its content. Folic acid supplementation overcomes these obstacles with little risk, as it has no known toxicity. Women taking folic acid who are current or former users of oral contraceptives may require additional zinc. And be sure to augment your folic acid supplement with its synergistic counterpart, vitamin B12.
Focus on Fiber
The American Heart Association came out squarely behind fiber in a June 16, 1997 issue of its journal Circulation: Double your daily intake to lower cholesterol and the risk of heart disease. The American diet is consistently low in fiber, notes Linda Van Horn, PhD, RD, author of the article. Twenty-five to 30 grams a day from foods (or supplements) are not only heart healthy but seem to aid weight control.
Getting enough iron? An estimated 25% of adolescent girls in the United States are iron deficient, according to an October 12, 1996 issue of the British medical journal The Lancet, which reported that girls who took iron supplements performed significantly better on verbal tests than those who took a placebo. "Teenage girls should be regularly tested for iron deficiency because rapid growth and the onset of menstruation during puberty increase the body's need for iron," says Ann Bruner, MD, of the Johns Hopkins Children's Center and a lead author of the study.USDA data reveal that women up to age 50 also tend to get much less than recommended levels of iron, a lack of which leads to anemia, a deficiency of red blood cells, hemoglobin or volume of blood. For kids, deficiency is more common from six months to four years and during the rapid growth spurts of adolescence when the body is growing so quickly that the body's iron stores may sink to dangerous levels. Vegetarian women run the greatest risk for deficiency, as meat is iron-rich; foods like beans, grains and vegetables also contain some iron. Supplements, of course, supply easily absorbable iron. And to absorb iron from vegetarian sources, take vitamin C with your meals. That boosts the amount of this mineral you will take in. Bear in mind, however, that certain folks-older men and post-menopausal women-generally have adequate dietary supplies of iron. Of greater concern, in fact, is excessive iron, and for these folks iron-free multivitamin and mineral supplements are available.
Ante Up the Antioxidants
Antioxidant nutrients help protect the body from oxygen-scavenging molecules called free radicals. The products of pollution, the body's own metabolic processes and other sources, free radicals are linked to heart disease, cancer and other chronic health problems. The most important antioxidants, which include vitamin C, E, beta carotene, and selenium, are often lacking in the American diet. Plus, optimal amounts of vitamin E cannot be consumed from food. You need supplements. The bottom line: even though we live in a land of plenty, you can still miss vital nutrients. So make sure to consume these vital substances.
Source of Missing Nutrients In the search for the nutrients missing from America's diet, one big help is the sprout. The sprout is truly one of nature's heavyweights: fresh, tiny and moist, its power punch of vitamins, minerals, protein, chlorophyll and disease-busting phytochemicals land it in a weight class far beyond that of its full-grown competitors. Size does NOT matter to this nutritional giant. A championship belt currently wraps around the miniscule broccoli sprout, catapulted into the ring by Paul Talalay, MD, professor of pharmacology and molecular sciences at Johns Hopkins University. Dr. Talalay discovered that the seedlings contain substantially more of the cancer-fighting substance sulforaphane than mature plants (Proc. Natnl. Acad. Sci. USA, 94, 10367-10372). Sprouts, the quintessential health food of the Sixties, provide a wonderfully varied and versatile way to get your daily greens. Raw or cooked, strong or mild, vegetable and grass sprouts and their algae cousins add low-calorie texture to recipes and a rich, diverse complement of nutrients and fiber.
Ancient Asia to the Modern Lab
Asians stir-fried sprouts as one of the earliest fast foods as long as 5,000 years ago. The ancient Chinese relied on sprouts for year-round vegetables in colder regions of their vast country. Today, researchers studying sprouts and adult plants have identified their important chemoprotective and other health-bolstering substances. In Paul Talalay's research project at Johns Hopkins, scientists found that three-day-old broccoli sprouts contain up to 50 times more sulforaphane than mature plants, which prompts the body to produce an enzyme that prevents cancer tumors from forming. Uniform levels of the compound saturate the shoots, unlike the chemically uneven adult plants. The Brassica family of broccoli and cabbage is richly endowed with phytochemicals that also help reduce estrogen levels associated with breast cancer. Other phytochemical compounds in the Brassica family are associated with the prevention of stomach and lung cancers. Most of the initial landmark work on phytochemicals' cancer-fighting powers has taken place since 1989 under the aegis of the National Cancer Institute's "Designer Food Program," which isolated, for example, the isoflavones in beans that seem to neutralize cancer-gene enzymes.
Strong Suit: Soy and Spirulina
The isoflavones and phytosterols in soy produce an estrogenic effect that appears to relieve menopausal symptoms and help prevent breast cancer. Soy foods expert Mark Messina, PhD, has done extensive work on the subject, some of which has been published in the Journal of the National Cancer Institute 83, 1991: 541-6. Researchers also have synthesized a bone-strengthening form of soy isoflavones called ipriflavone, following impressive clinical trials in the treatment of osteoporosis (American Journal of Medicine, 95 [Suppl. 5A] (1993): 69S-74S). Spirulina and other micro-algae are fascinating organisms that inhabit a niche between the plant and animals kingdoms. Named for its tiny spirals, spirulina, a blue-green algae, grows in saline lakes but is cultured for maximum nutritional content. In her book Whole Foods Companion (Chelsea Green), Dianne Onstad notes that spirulina contains "the highest sources of protein, beta carotene and nucleic acids of any animal or plant food." Its nucleic acids, she says, benefit cellular regeneration; its fatty acids, especially GLA and omega-3 acids, make it one of the most complete foods. Sprouts, like any other produce, should be rinsed thoroughly before serving. People at high risk for bacterial illness-young children, the very elderly or folks with weakened immune systems-should limit their consumption of raw sprouts. But no matter how you eat them, you may find more spring in your step from these tiny, sprouting nutritional wonders.
Celebrating Women: Age Is Just a Number
June 13, 2005 07:43 PM
Author: Darrell Miller
Subject: Celebrating Women: Age Is Just a Number
Celebrating Women: Age Is Just a Number by Carl Lowe Energy Times, March 10, 2004
As women age, their physical needs shift. The health challenges that face a woman in her thirties do not match those of a woman in her fifties.
At the same time, some basic health needs stay constant: At any age, every woman requires a wealth of vitamins, minerals and the other natural chemicals that fruits, vegetables and supplements supply. She also constantly needs families and friends to support her spiritual health.
As the internal workings of your body alter, your lifestyle must stay abreast of those adjustments. Peak health demands a finely tuned health program designed with your individual needs-and your stage of life-in mind.
Ages 30 to 45
When it comes to maintaining health, younger women might seem to have it easier than older women. If they exercise and stay in shape, they maintain more stamina than women 10 to 20 years their senior.
Unfortunately, many women in this age group mistakenly think they don't have to be as careful about their lifestyle habits and their eating habits as they will in later decades. But even if your health doesn't seem to suffer from poor eating choices or a sedentary lifestyle right away, your foundation for health in later life suffers if you don't care for yourself now.
By age 45 you should have established the good habits that will carry you successfully through the aging process. As an added bonus, good lifestyle habits pay immediate dividends. If you pay attention to your nutrients and get plenty of physical activity when younger, you'll feel more energetic and probably enjoy better emotional health.
Set Health Goals
According to Gayle Reichler, MS, RD, CDN, in her book Active Wellness (Avery/Penguin), good health at any age doesn't just come to you-you have to plan for it. In order to stick to good habits, she says, "living a healthy lifestyle needs to be satisfying." Reichler believes that you need to picture your health goals to achieve them: "Every successful endeavor first begins in the mind as an idea, a thought, a dream, a conviction." Good health at this age and in later years requires a concrete strategy and visualization of how your body can improve with a healthy lifestyle.
Your long-term health goals at this age should include an exercise program that will allow you to reach a physically fit old age with a lowered risk of disability. In addition, your short-term plans should encompass losing weight, staying optimistic, living life with more vim and vigor, increasing your capacity for exercise and lowering your stress.
As Reichler points out, "Your long-term goal and your ideal vision establish what you want to achieve....[You should do] something good...for yourself every day and every week that makes your life easier and more consistent with your goals."
Develop an Eating Plan
Today, the average American gains about two pounds annually. As a result, every year a greater portion of the US population is obese and overweight. By controlling your food intake earlier in life, you may be able to avoid this weight gain. In his book Prolonging Health (Hampton Roads), James Williams, OMD, recommends basic changes to your diet that can provide long-term support of your health: • Cut back on sugar. Dr. Williams says that, "Over my more than 20 years of clinical practice, I have found that nothing undermines health more than refined sugar." • Limit your carbohydrates, especially the refined ones. Dr. Williams says you should "substitute whole grain breads for...white bread....[A]void commercial breakfast cereals....[E]at small amounts of beans several times a week." • Cut calories. Cutting the amount of food you eat supports health in a number of ways and is believed to boost longevity. Dr Williams notes, "Calorie restriction is necessary...to normalize your weight...to reduce the metabolic burden of overeating on your liver and intestinal tract and to minimize insulin production from the glucose spikes caused by overeating." Problems with insulin production, linked to diabetes, may result from eating large amounts of sugary foods and little fiber, and are thought to accelerate aging. • Eat mostly low-fat foods. Check product labels to limit fat. Foods that are high in healthy omega-3 fats, like fish and soy, can be eaten more often. • Eat foods high in lean protein. Reichler recommends meats like lean beef, poultry, beans and non-fat dairy. • Eat fish. It provides a wealth of healthy fats and protein. "Fish, because it contains the good omega-3 fats, does not need to be lean; the same is true for soy products that do not have added fat," adds Reichler.
Get Supplemental Help
If you're in your thirties or forties and you don't take at least a multivitamin, start taking one today! A large body of research shows that taking vitamin and mineral supplements over a long period of time significantly supports better health.
Calcium and vitamin D are two of the most important supplemental nutrients, helping to build stronger bones now that can withstand the bone-loss effects of aging.
Calcium can also help keep your weight down. One study of younger women found that for every extra 300 milligrams of calcium a day they consumed, they weighed about two pounds less (Experimental Biology 2003 meeting, San Diego).
In the same way, taking vitamin D supplements not only helps strengthen your bones, it can also lower your risk of multiple sclerosis (Neurology 1/13/04). In this study, which looked at the health records of more than 180,000 women for up to 20 years, taking D supplements dropped the chances of multiple sclerosis (although eating vitamin D-rich foods did not have the same benefit). And if you're thinking about having children at this age, a multivitamin is crucial for lowering your baby's risk of birth defects and other health problems. A study at the University of North Carolina at Chapel Hill found that women who take multivitamins during pregnancy lower their children's risk of nervous system cancer by up to 40% (Epidemiology 9/02).
" Our finding, combined with previous work on reducing several birth defects with vitamin supplementation and other childhood cancers, supports the recommendation that mothers' vitamin use before and during pregnancy may benefit their babies' health," says Andrew F. Olshan, MD, professor of epidemiology at the UNC School of Public Health. "We believe physicians and other health care providers should continue to educate women about these benefits and recommend appropriate dietary habits and daily dietary supplements."
In particular, Dr. Olshan feels that folic acid (one of the B vitamins), and vitamins C and A, are particularly important for lowering the risk of childhood cancers and birth defects.
Ages 45 to 55
When you reach this in-between age-the time when most women have moved past childbearing age but haven't usually fully moved into the post-menopausal stage-you enjoy a propitious opportunity to take stock of your health and plan for an even healthier future. One thing that may need adjustment is your sleep habits, as sleeplessness is a common problem for women in this age group. Even if you haven't been exercising or watching your diet until now, it's not too late to start. Making lifestyle changes at this age can still improve your chances for aging successfully.
For instance, it is at these ages that women should have their heart health checked. Research published in the journal Stroke (5/01) shows that having your cholesterol and blood pressure checked at this time more accurately shows your future chances of heart disease than having it checked at a later date after menopause, in your late fifties.
" The premenopausal risk factors may be a stronger predictor of carotid atherosclerosis [artery blockages] because they represent cumulative risk factor exposure during the premenopausal years, whereas the risk factors...during the early postmenopausal years have a shorter time for influence," says Karen A. Matthews, PhD, a professor at the University of Pittsburgh Medical Center. In other words, Dr. Matthews' research shows that if you have high blood pressure and high cholesterol before menopause, you are at serious risk for a stroke or heart attack soon after menopause: These are important reasons that you need to start improving your health habits immediately.
Increase in Heart Disease
Before menopause, a woman's hormones and other physiological characteristics usually hold down her chance of heart disease. After menopause, when hormones and other bodily changes occur, the risk of heart attacks and stroke in women rises significantly. (Heart disease is the leading killer of women.) At least part of this increased risk is linked to the postmenopausal decrease in estrogen production.
Dr. Matthews studied about 370 women in their late forties, measuring their weight, their BMI (body mass index, an indication of body fat compared to height), blood pressure, cholesterol and blood sugar. Ten years later, after the women had entered menopause, she and her fellow scientists used ultrasound to measure blockages in these women's neck arteries (a sign of heart disease).
The researchers found that indications of potential heart problems (such as high blood pressure, high cholesterol and being overweight) when women were in their forties did indeed forecast future difficulties.
" Women who had elevated cholesterol, higher blood pressures and increased body weight before menopause had increased blood vessel thickening and atherosclerotic plaque formation in the neck arteries after menopause. Such changes in the carotid arteries are associated with an increased heart attack and stroke risk," says Dr. Matthews.
Heart Health Factors
The four main lifestyle factors you should adjust at this age to support better heart function are diet, stress, exercise and weight. According to Dr. James Williams, "[M]ore than any other cause, dietary factors are the most critical factor in cardiovascular disease." He recommends eliminating "dietary saturated fatty acids as found in flame-broiled and fried meats." He also urges women to eat more fish and poultry, consume organic fruits and vegetables and cut back on refined sugar.
Stress becomes an ever more important heart disease factor at this age as estrogen begins to drop.
" Our study [in the lab] indicates that stress affects estrogen levels and can lead to the development of heart disease-even before menopause," says Jay Kaplan, PhD, of the Wake Forest University Baptist Medical Center (The Green Journal 3/02).
Dr. Kaplan's research shows that stress in women ages 45 to 55 may reduce estrogen earlier in life and make women more susceptible to the arterial blockages that lead to heart disease. "We know from [lab] studies that stress can lower estrogen levels to the point that health is affected," he says.
Stress can also hurt bone health: In a study of 66 women with normal-length menstrual periods, estrogen levels were low enough in half of the women to cause bone loss, making the women susceptible to osteoporosis.
Exercise and Weight
Although exercise used to be considered to be mainly a young woman's activity, the thrust of recent research suggests that physical activity actually becomes more important to health as you get older.
A 17-year study of about 10,000 Americans found that exercising and keeping your weight down is probably the most important thing you can do to lower your risk of heart disease as you enter your forties and fifties (Am J Prev Med 11/03).
Of the people who took part in this study, more than 1,500 people died of heart disease. Those who performed the most exercise were thinner and had a 50% chance less of dying of heart disease than overweight nonexercisers.
" The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, a researcher at the Albert Einstein College of Medicine in the Bronx, New York.
An added benefit of exercise: If you burn up calories exercising, you can eat more and not have to worry as much about being overweight.
Supplements and Diet
If you're a woman at midlife, a multivitamin and mineral is still good nutritional insurance. Eating plenty of fruits and vegetables are also important for getting enough phytochemicals, the health substances in plants that convey a wealth of health benefits.
As you enter this age group, your immune system gradually slows down. To help support immune function, eating produce rich in antioxidant nutrients, and supplementing with antioxidants like vitamins C and E as well as carotenoids, can be especially important. For example, a study of people with ulcers found that people with less vitamin C in their stomachs are more likely to be infected with Helicobacter pylori, the bacteria that can cause peptic ulcers and is linked to stomach cancer (J Amer Coll Nutr 8/1/03).
This research, which looked at the health of about 7,000 people, found that vitamin C probably helps the immune system fend off this bacterial infection.
" Current public health recommendations for Americans are to eat five or more servings of fresh fruits and vegetables a day to help prevent heart disease, cancer and other chronic diseases," says Joel A. Simon, MD, MPH, professor of medicine at the University of California at San Francisco.
Calcium and Bones
At midlife, calcium continues to be a vital mineral for supporting bone health.
According to Gameil T. Fouad, PhD, "It has been routinely shown that a woman's calcium status and level of physical activity (specifically, the degree to which she participates in weight-bearing exercise) are positively associated with bone mineral density. It is less well appreciated that this is a process which takes place over the course of a lifetime."
Dr. Fouad adds that calcium works in concert with other vitamins and minerals to keep bones healthy: "Research in the United Kingdom involving nearly 1,000 premenopausal women over age 40 illustrates those women with the highest bone density tended to have the highest intake of calcium. Surprisingly, this study also demonstrated that calcium does not act alone: those women with the best bone health also had the highest intakes of zinc, magnesium and potassium."
Dr. Fouad stresses that supplements should go together with a lifestyle that includes enough sleep and exercise to help the body stay in top shape.
" As a general guideline," he says, "a woman concerned with her mineral intake should take concrete steps to make sure she is getting adequate rest, is eating a well-balanced diet focused on fresh fruits, vegetables and lean protein as well as getting adequate exercise....A multi-mineral containing bio-available forms of zinc, magnesium, copper and selenium is probably a safe addition to anyone's routine. Taking these proactive steps dramatically reduces the chances that deficiencies will arise."
Ages 55 and Beyond
Entering the post-menopausal phase of life can present challenging opportunities for a new perspective on life and health. While some signs of aging are inevitable, experts who have looked at how the human body changes with age are now convinced that healthy lifestyle habits can improve how well you can think, move and enjoy life well past age 55.
As Dr. Williams notes, "In your fifties, the force of aging is undeniably present: Your body shape changes and organ function declines, both men and women have a tendency to gain weight....Heart disease becomes more common, energy and endurance are considerably reduced and your memory begins to slip."
But Dr. Williams also points out that you don't have to age as rapidly as other people do. He believes you should employ a "natural longevity program...[that starts] to reverse the course of aging as early as possible."
One key to staying vital as you age is your outlook on life, an aspect of life that's greatly enhanced by strong social ties.
Avoiding the Aging Slowdown The latest research shows that one of the most crucial ways to slow the effects of aging is to exercise and keep your weight down. It won't necessarily be easy, though. The change in hormonal balance at this age makes the body more prone to extra pounds (Society for Neuroscience Meeting, 11/12/03).
" In women, it has been demonstrated that major weight increases often occur during menopause, the time in a woman's life in which cyclic ovarian function ends and the ovarian hormones estrogen and progesterone decline," says Judy Cameron, PhD, a scientist in the divisions of reproductive sciences and neuroscience at the Oregon Health & Science University.
In Dr. Cameron's lab trials, she has found that the decrease in estrogen after menopause "resulted in a 67% jump in food intake and a 5% jump in weight in a matter of weeks."
In other words, the hormonal changes you undergo as enter your late fifties causes your appetite to grow as well as your waistline: Developments that increase your chances of heart disease, cancer, diabetes, stroke and joint problems.
Vigilance against this weight gain is necessary to save your health: Start walking and exercising. Research on exercise in people aged 58 to 78 found that getting off the couch for a walk or other physical activity not only helps control weight but also helps sharpen your thinking and helps you become more decisive (Proceedings of the National Academy of Sciences, 2/16-20/04, online edition). This recent study, done at the University of Illinois at Urbana-Champaign, found that performing aerobic exercise improved mental functioning by 11% (on a computer test).
" We continue to find a number of cognitive benefits in the aerobic group," says Arthur F. Kramer, PhD, a professor of psychology at the Beckman Institute for Advanced Science and Technology at Illinois. "The brain circuits that underlie our ability to think-in this case to attend selectively to information in the environment-can change in a way that is conducive to better performance on tasks as a result of fitness." In simple terms, that means that walking at least 45 minutes a day boosts brain power as well as protecting your heart.
An Herb for Menopause
The physical changes that accompan> y menopause can be uncomfortable. But traditional herbal help is available: Black cohosh (Cimicifuga racemosa), an herb used for eons by aging women, has been shown in recent studies to be both safe and effective (Menopause 6/15/03).
" This [research] should reassure health professionals that they can safely recommend black cohosh to their menopausal patients who cannot or choose not to take HRT [hormone replacement therapy]," says researcher Tieraona Low Dog, MD, Clinical Assistant Professor at the University of New Mexico Department of Family and Community Medicine.
While HRT has been used to help women cope with menopause, a flurry of studies in the past few years have shown that HRT increases the risk of heart disease and cancer. Instead, black cohosh, which alleviates such menopausal discomforts as hot flashes, has been shown to be much safer.
Keeping Track of Crucial Vitamins
While continuing to take multivitamins and minerals at this age is important, some experts believe that as we grow older, vitamin D supplementation, as well as taking antioxidant nutrients, is particularly vital. Arthritis is a common affliction of aging, and rheumatoid arthritis (RA) is one particularly destructive form of this joint problem. But taking vitamin D can significantly lower your risk of this condition.
When scientists analyzed the diets of 30,000 middle-aged women in Iowa over 11 years, they found that women who consumed vitamin D supplements were 34% less likely to suffer RA (Arth Rheu 1/03).
Other vitamins are equally important to an older woman's well-being. For example, vitamins C and natural E have been found to lower the risk of stroke in those over the age of 55 (Neurology 11/11/03). In this study, smokers who consumed the most vitamin C and natural vitamin E were 70% were much less likely to suffer strokes than smokers whose diets were missing out on these vitamins.
Rich sources of vitamin C in food include oranges and other citrus fruits, strawberries, red and green peppers, broccoli and brussels sprouts. Sources of vitamin E include vegetable oils such as sunflower seed, cottonseed, safflower, palm and wheat germ oils, margarine and nuts.
Saving Your Sight
After age 55, your eyes are particularly vulnerable. Eight million Americans of this age are at risk for age-related macular degeneration (AMD), a condition that destroys structures in the back of the eye necessary for vision (Arch Ophthal 11/03). But you can drop your risk of AMD by taking supplements of antioxidant vitamins and zinc, according to researchers at Johns Hopkins' Wilmer Eye Institute.
Their research shows that a dietary supplement of vitamins C, natural vitamin E and beta carotene, along with zinc, lowers the chances of progressing to advanced AMD in certain at-risk people by about 25%. Daily supplements also reduced the risk of vision loss by about 19%.
The carotenoids lutein and zeaxanthin also help protect aging eyes. When scientists compared healthy eyes with eyes suffering from AMD, they found that AMD eyes contained lower levels of these vital nutrients (Ophthalmology 2003; 109:1780). Furthermore, they found that levels of these chemicals generally decline as you grow older.
Healthy at All Ages
When it comes to designing a healthy lifestyle, general rules like these can be followed, but you should individualize your plan to fit your needs. No matter which type of exercises you pick out or what healthy foods you choose, look for a strategy and a plan you can stick to. If you think a selection of foods are good for you but you absolutely hate their taste, chances are you won't be able to stick to a diet that includes them.
The same goes for exercise: Pick out activities that you enjoy and that you can perform consistently. That increases your chance of sticking to an exercise program.
Staying healthy is enjoyable and it helps you get more out of life every day, no matter what stage of life you're in.
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Cancer at the Millenium - the war on cancer entering its third decade...
June 13, 2005 10:23 AM
Author: Darrell Miller
Subject: Cancer at the Millenium - the war on cancer entering its third decade...
Cancer at the Millenium by Harriet Brown Energy Times, May 1, 1999
With the war on cancer entering its third decade, the necessity grows clearer for medical science to engage the enemy on several fronts. Until recently, high-tech medical weapons like vaccines and gene therapy, inspired by a flood of insights into the molecular basis of cancer, garnered most of the hope, hype, headlines and research money. The science was sexy and the prospect of a "cure" dramatic. But, today, advocates of prevention receive equal, if not greater, attention.
Improving our diets and prudently supplementing with vitamins and minerals, can deliver a major preventive impact. Contentious experts concede that at least a third (and probably more) of all cancers can be blamed on a combination of eating too much of the wrong foods and not enough of the right ones.
The Dietary Difference
Though cancer can progress rapidly once it leaps past its inception, it develops over many years and in several stages. Beneficial compounds in food and supplements may intervene along a line that runs from initial exposure to carcinogens to the final step into outright malignancy. Nutrients may: - counteract environmental poisons and the toxic byproducts of liver metabolism - neutralize free radicals (which might otherwise cause carcinogenic mutations in DNA) - boost the immune system - inhibit enzymes that drive cell proliferation - halt metastasis (cancerous reproduction)
The Big Picture The dietary guidelines advocated by the American Cancer Society and the National Cancer Institute (which generally coincide with those of most health organizations) may sound familiar: Eat plenty of fruits and vegetables. Get lots of fiber. Limit fat, especially animal fat. Go easy on meat and avoid the cured variety (they contain nitrites). If you drink alcohol, do it in moderation. Watch your total calories, and your weight. Pretty straightforward stuff.
Carotenoids, as their name suggests, are orange and red pigments in fruits and vegetables, most notably carrots and tomatoes, although they're also in everything from sweet potatoes to spinach and brussels sprouts (in the latter their distinctive color is masked by green chlorophyll).
Lycopene, a carotenoid found primarily in tomatoes, displays double the free radical-fighting activity of beta carotene, the most widely studied carotenoid. Of 72 studies looking at consumption of tomatoes or tomato-based products reviewed in the February 1999 Journal of the National Cancer Institute, almost half showed a significant reduction in one or more of a variety of cancers.
Research shows that lycopene may be best at lowering a man's risk of prostate cancer. A 1995 Harvard Medical School study (Journal of the National Cancer Institute 1995; 87: 1767-76) queried nearly 48,000 male health-care professionals about their consumption of fruits and vegetables. The only foods that reduced their risk of prostate cancer were, apparently, tomato sauce, tomatoes, pizza (tomato paste). For those who ate ten servings a week, risk dropped 45 percent; with four to seven servings, 20 percent. In animal studies lycopene decreased the number and size of mammary tumors (Eleventh International Symposium on Carotenoids, 1996).
Tomatoes are one of the richest sources of lycopene. Cooking tomatoes helps by releasing the lycopene from the plant cell walls. Also, the oil in tomato sauce enhances absorption in the stomach. Lycopene is also available in supplements.
Wine drinkers rejoiced when resveratrol, a constituent of the skin of red grapes, was found to protect their hearts (by blocking oxidation of LDL cholesterol and discouraging blood clotting). Now they have another reason to toast this potent antioxidant. When researcher John Pezzuto at the University of Illinois at Chicago screened about 1,000 plants for anticancer activity, he came up with one whose active ingredient turned out to be resveratrol. In lab tests it squelched both free radicals and inflammation, two well-known cancer inducers (Science, 6/10/97). In a study with mice, resveratrol reduced the number of skin tumors by up to 98 percent compared to control animals. Because the effective doses were high (Pezzuto estimates a person would have to quaff about five gallons of wine a day to get the equivalent) and because more than a drink or two a day may raise the risk of breast cancer, researchers don't recommend nondrinkers take up wine. But supplements of synthesized resveratrol (as well as grape juice) may help.
Saturated fat is an authentic dietary villain. Aside from clogging arteries, it's a suspected contributor to several cancers, though the evidence is greater for some cancers (prostate) than for others (breast cancer)
Of the two other main categories of fats, monounsaturated and polyunsaturated, mono seems benign, if not positively protective. For example, in a study of the influence of diet on breast cancer, Greek researchers discovered that women who consumed higher amounts of olive oil (which is mostly mono) were less likely to be afflicted with breast cancer (Journal of the National Cancer Institute 1995: 87; 110-116).
When it comes to polyunsaturated fats, however, things get complicated. The fat that predominates in corn, sunflower and other vegetable oils, called omega-6, has long been associated with cancer risk in animal experiments. Likewise the type found in margarines, trans fats, which are partially saturated vegetable oils. On the other hand, the omega-3 fats called EPA and DHA, which are found primarily in deep- and cold-water fish like cod, mackerel, and halibut, protect against both heart disease and cancer. In an epidemiological study covering 24 European countries, British researchers established that mortality rates for colon and breast cancers declined as fish and fish oil consumption rose (British Journal of Cancer 1996: 74; 159-64). And Finnish scientists discovered that the breast tissue of women who had breast cancer contained significantly less DHA and EPA than the breasts of healthy women (Nutrition and Cancer 1995: 24; 151-160).
Experts believe the omega-3s' anticancer effect derives from its ability to tamp down the prostaglandins that stimulate inflammation. Chronic inflammation unleashes a steady stream of free radicals, which can damage DNA and thereby trigger cancer. Omega-3s also help the liver detoxify potentially harmful substances.
Fortunately for the fish-phobic, nonmarine sources of omega-3 fats include flaxseed and hemp oils.
Minerals to Lower Cancer Risk
n Calcium: possibly protective against colon cancer. In a recent trial (New England Journal of Medicine, 1/14/99) researchers gave people with a history of precancerous colon polyps either two 600 mg calcium tablets a day or a placebo for nine months and found fewer polyps. n Selenium: powerful antioxidant and supporter of immunity. Researchers find that cancer rates in various regions is lowered when soil and vegetables contain more selenium
In a selenium-depleted area in China afflicted with one of the highest incidences of stomach and esophageal cancer mortality in the world, scientists asked different groups to take various combinations of nutrients. After five years they found a significant reduction in the cancer rate among those who had gotten supplements of selenium, vitamin E and beta carotene (Biological Trace Element Research 1985; 7: 21-29). In the U.S. researchers studying the potential effectiveness of selenium supplementation for preventing nonmelanoma skin cancers came up with a surprise. The 200 mcg a day the subjects received for an average of 4.5 years had no impact on skin cancer but did significantly cut the rates of lung, colorectal and prostate cancers (Journal of the American Medical Association, 12/25/96).
More recently Harvard researchers determined that men with prostate cancer had much lower levels of selenium in their toenails (a measure of consumption) than healthy men (Journal of the National Cancer Institute, 8/119/98).
Cruciferous vegetables like broccoli, brussels sprouts, cauliflower and kale, have long been singled out for their association with protection against cancer. In a 1996 survey of 94 population studies and clinical trials focusing on consumption of cruciferous vegetables, 67 percent showed a reduced risk, the strongest link being with lung, stomach, colon and rectal cancers (Cancer Epidemiological Biomarkers 1996; 5: 733-748).
Scientists at Johns Hopkins showed that sulforaphane, from these plants, stimulates enzymes that help detoxify carcinogens generated in the liver. When they injected rats with a cancer-causing chemical, only 26 percent of the rodents pretreated with sulforaphane developed mammary cancer, compared to 68 percent of controls. Even animals who did come down with cancer had tumors that appeared later and smaller.
Other researchers have focused on a cruciferous-vegetable compound called indole-3-carbinol, which has proved especially effective against breast cancer cells. Recently, scientists at the University of California at Berkeley found that indole-3-carbinol, rather than acting as an anti-estrogen, (as had been thought), actually stops breast cancer cells by turning off a protein critical to their replication (Jrnal of Bio Chem, 2/13/98). Consequently, when treating certain forms of cancer, some doctors have paired indole-3-carbinol with the chemotherapy drug tamoxifen - which counteracts estrogen - and found that the combination has proven more potent than either separately.
Several decades ago British physician Denis Burkitt proposed that the low incidence of colon cancer among native peoples in South Africa was attributable to the fact that their diet was rich in fiber. The fiber, it was hypothesized, bulked up the stool, speeding its passage through the bowel and reducing the time carcinogens contact its lining; it also helped neutralize cancer-promoting bile acids.
This concept has been backed up by numerous studies. Recently, Harvard researchers sprinkled cold water on this idea, finding that an examination of the eating habits of more than 80,000 female nurses, could find no protective effect against colon cancer or precancerous polyps from consuming fiber (NEJM, January 21, 1999). Most experts' take on this apparent refutation: Maybe the "high fiber" intake in this case wasn't high enough, and this is just one study among many.
Fighting Breast Cancer
Fiber has also been linked to reduced rates of breast cancer. At first it was thought that if fat was a breast-cancer culprit, fiber might just be a marker for a low-fat diet. But a look at Finland undermined that idea: Finnish women eat both a lot of fat and a lot of fiber, and their breast cancer rate ranks much below that in the U.S., (where we eat gobs of fat and little roughage).
Fiber helps take estrogen out of circulation as it passes through the liver, while the isoflavones in many high-fiber plants and vegetables are themselves weak estrogens, which compete for slots on breast tissue's estrogen receptors. The special fiber in flaxseed oil called lignans act against estrogen in two ways: by binding its receptors and by inhibiting the enzyme that converts other hormones into estrogen.
Fiber comes in two basic forms, insoluble (e.g., wheat bran, celery, the skins of fruits and vegetables) and soluble (e.g., oat bran, citrus fruits, beans). Until a few years ago, scientists believed that cancer protection came mainly from insoluble fiber, but that thinking has turned around.
A soluble fiber called citrus pectin has been shown to halt the tendency of prostate, lung, breast and skin cancers to metastasize, or spread (e.g., Journal of the National Cancer Institute 1995; 87: 3448-353). Typically cancer turns deadly only when it gets into the bloodstream and invades new territory. Modified citrus pectin appears to stop this aggression by preventing cancer cells from attaching to healthy tissue.
While the name inositol hexaphosphate (IP6) sounds like a mouthful, many of us consume mouthfuls of this natural substance every day - in foods like corn, rice, whole-grain cereals, oats and wheat.
But now scientists have isolated IP-6 and found that this powerful antioxidant can slow the destructive cellular processes that lead to tumors. In a study published in Anti-Cancer Research (Nov/Dec 1998), scientists at the University of Maryland School of Medicine demonstrated that IP-6 could shrink liver tumors in laboratory animals.
The researchers believe that IP-6 can help prevent cancer and also be useful in lowering the risk of health problems like kidney stones and heart disease. Research like this continues to expand our knowledge of how to lower the risk of cancer. In the next millennium, with more and more information making its way into the media and onto websites, our power and the responsibility to reduce our risk of cancer will continue to grow and offer new possibilities.
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Fats for Life - the quality of the fat you eat is probably much more important than the...
June 12, 2005 02:39 PM
Author: Darrell Miller
Subject: Fats for Life - the quality of the fat you eat is probably much more important than the...
Fats for Life by Henry Wolfe Energy Times, August 6, 2003
For years, many experts argued that the only good fatty foods were the ones you didn't eat. That was a big, fat mistake. Overwhelming evidence now shows that certain fats are not only necessary for optimal health, but that the quality of the fat you eat is probably much more important than the quantity.
Threatening Trans Fats
"The biggest thing wrong with the fats Americans eat today is that they are eating too many trans fatty acids," says Fred Pescatore, MD, author of The Allergy and Asthma Cure (John Wiley). "About 42,000 foods contain trans fats. These fats are linked to a higher risk of heart disease, stroke and cancer."
Trans fatty acids are fats that form when food manufacturers add hydrogen to fat molecules, a process called hydrogenation that makes fats stay fresh longer without growing rancid. Trans fats also form when foods are fried.
Hydrogenation extends the shelf life of refined foods like cakes, donuts, and crackers. Unfortunately, it also creates fats that many experts believe can compromise your health. In a study of the health effects of trans fats, 26 people agreed to eat a diet that changed every five weeks, continually shifting the types of fats in their meals (American Heart Association's Scientific Sessions 2000). All of the diets in the study provided 30% of calories from fat. One fifth of the fat came from either soybean oil, semi-liquid margarine, tub margarine, shortening, stick margarine or butter.
"We were interested in assessing what would happen when we substituted one fat for another," notes researcher Alice H. Lichtenstein, DSc, professor of human nutrition at Tufts University, Boston.
The study showed that as people ate more trans fatty acids (in the more solid margarines) and fewer polyunsaturated fats (in the liquid oils), their triglycerides increased after each meal. Triglycerides are blood fats that boost heart disease risk.
For instance, when these folks ate stick margarine, which is high in trans fats, their triglycerides climbed an average 18% higher than when they ate semi-liquid squeeze bottle margarine, a type of margarine that is softer because it is less hydrogenated. Stick margarine raised heart disease risk by causing a drop in HDL, or "good" cholesterol. Although butter increased HDL, it also caused a significant increase in LDL, the "bad" cholesterol that raises heart disease risk.
"The best dietary advice we can give people is to minimize their intake of animal and hydrogenated fats in order to reach the American Heart Association's target of 10% or less of total calories from saturated fat and trans fatty acids," Dr. Lichtenstein says. "That would mean consumers choosing low-fat and non-fat dairy products and lean cuts of meat, and the food industry decreasing the amount of hydrogenated fats used in their products." According to a study at Johns Hopkins University (Amer Coll of Card, 52nd Scientific Session, 3/30/03, Chicago), people who eat saturated fat have more visceral fat, fat surrounding their internal organs. This fat around the waist is now seen as a risk factor for heart disease and other illnesses.
Another hidden problem in our fat consumption, according to Dr. Pescatore, hides within canola oil. Dr. Pescatore says that although many consumers believe canola oil is beneficial to health, the refined canola oil sold in the US has had its potential health benefits removed during processing.
"People still think canola oil is healthy and eat too much of it," he says. "The problem with canola is that it is highly processed and refined....Processors hydrogenate canola oil to keep it from getting rancid."
According to Fred Ottoboni, PhD, coauthor of The Modern Nutritional Diseases (Vincente Books), "Canola oil is lightly hydrogenated to take out the omega-3 fatty acids (the healthiest, but most unstable, fats) and then the food manufacturers filter the trans fats out. I don't worry about the trans fats in canola, but the problem is the huge ratio of omega-6 fatty acids to omega-3s."
To get more of the omega-3 fatty acids, which are lacking in most Americans' diets, Dr. Pescatore advocates using macadamia nut oil. "Macadamia nut oil is higher in monounsaturated fats than olive oil; it is the healthiest fat with an omega-3 to -6 ratio of one to one."
The Omega-3 Difference
Omega-3 and omega-6 fatty acids are basic forms of fat found in oils. Fish oil, hempseed and flax oil are high in what are called omega-3s. Certain plant-derived oils like corn and soy are richer in omega-6 fatty acids.
"Primitive humans ate a diet that contained a one-to-one ratio of omega-3s and omega-6s," says Dr. Pescatore. "Today we (Americans) eat 20 times more omega-6 than -3; that's why we suffer so much chronic disease and chronic inflammation. For instance, the Japanese eat a (much better) diet that contains a two-to-one ratio of omega-6 fatty acids to omega-3." "Not all omega-6s are bad," he adds, "we just eat too many of them."
Switching to healthier fat isn't hard. Eat more fish. When cooking, stick to oils like olive oil and macadamia oil. The quality of your oil and your health may improve in a big, fat way.
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The Joints Are Jumping
June 11, 2005 04:56 PM
Author: Darrell Miller
Subject: The Joints Are Jumping
The Joints Are Jumping by Rachel Alexander Energy Times, October 8, 2003
It usually starts with a twinge in your back or an ache in your knees: Knee stiffness, back pain and joint inflammation can signal the beginning of arthritis.
According to the US Food and Drug Administration, arthritis affects over 42 million Americans-that's 1 in every 3 adults-and costs the economy nearly $65 billion annually. But as common as arthritis is, it doesn't have to extract a high cost from your joints.
Who's At Risk?
Arthritis literally means an "inflammation of the joints" and can affect anyone-from small children to 80-year-olds. Some groups are more prone to certain types of arthritis; for instance, those over 40 are at greater risk for developing osteoarthritis, a degenerative condition of the joints.
According to Johns Hopkins Medical Institute, more than 50% of all individuals over the age of 40 have x-ray signs of osteoarthritis in weight-bearing joints (such as those in the knees and hips), and nearly half of those over 65 have measurable symptoms of arthritis. Osteoarthritis is often caused by overuse, age, excess weight or genetics, or by a combination of these factors.
Rheumatoid arthritis, on the other hand, is a disease of the immune system that affects the joints, which can make it harder to diagnose because early symptoms-fatigue, weakness, loss of appetite and low-grade fever-can mimic other chronic conditions.
Stiffness and pain may or may not accompany the initial symptoms of rheumatoid arthritis. However, joints eventually become inflamed and swollen. Although less common that osteoarthritis, rheumatoid arthritis affects more than 2 million Americans.
Covering Up the Signs
Treating arthritis can involve the use of both conventional and non-conventional therapies.
"In osteoarthritis specifically, conventional medicine has just been focused on covering up the symptoms," says Jason Theodosakis, MD, author of The Arthritis Cure (St. Martin's Press). "In the history of medicine, this approach has been considered primitive."
But Dr. Theodosakis points out that treatment often depends on the type of arthritis involved: "Rheumatoid arthritis patients should be taking prescription drugs that are known to prevent the disease from progressing. [Use] alternative medicine as an adjunct..."
Conventional therapies often involve the use of non-steroidal anti-inflammatory (NSAID) medicines, such as ibuprofen and naproxen. The chief drawback of NSAIDs is the toll these treatments extort from the gastrointestinal system.
In fact, a 2002 study conducted by researchers at the University of South Florida, Tampa, found that more than 15% of patients developed digestive problems after a five-week course of ibuprofen. In addition, ibuprofen may increase blood pressure.
Newer prescription NSAIDs called COX-2 inhibitors, which work by suppressing the body's inflammatory response, also carry risks of side effects ranging from diarrhea and fluid retention to liver damage and kidney problems. In addition, people with asthma or chronic allergies (including to aspirin) should not take these medicines.
Corticosteroids-another treatment option that has been used to lessen inflammation-can cause side effects such as increased appetite, mood changes and even immune system breakdown.
A growing body of evidence shows that nutrients such as glucosamine and MSM, coupled with lifestyle changes, can help decrease or eliminate some of the aches and pains of arthritis. Glucosamine is a natural chemical that helps build joints. When the cartilage in joints deteriorates due to age or other factors, studies indicate that glucosamine provides the necessary building blocks for rebuilding and repairing this tissue.
In one investigation (Archives of Internal Medicine 2002; 162:2113-23), scientists discovered that glucosamine slowed the progression of osteoarthritis and improved symptoms for over 200 patients. Another study, conducted by researchers in the Netherlands, demonstrated that a combination of glucosamine and chondroitin holds promise for conditions such as spinal disc degeneration.
To date, several studies have confirmed glucosamine's ability to help the symptoms of arthritis, and the National Institutes of Health is currently supporting research to further study the benefits of glucosamine.
Other Joint Aids
MSM is often an adjunct therapy as it does not work directly on joints, but provides the raw materials, in this case sulfur, to help rebuild cartilage in the joint matrix. Studies indicate that sulfur has a protective effect and may interact with magnesium, an essential bone nutrient.
Traditionally, the herb horsetail (Equisetum arvense) has been used to supply silica, a mineral component of nails, bones and joints. Its support of these structures can help in the fight against arthritis.
As the body ages, it may lose much of its silica reserves. Resupplying much of this mineral may help support joints. In addition, experts believe, silica can help the body use calcium more effectively and support bone health.
Since rheumatoid arthritis is a systemic affliction, you should work with a trained health professional in treating it. Complementary care practitioners often use antioxidant nutrients, such as vitamins C and E, to reduce free radical damage, along with pantothenic acid (vitamin B5) to lessen morning stiffness.
A Joint Project
According to Dr. Theodosakis, exercise is the key to dealing with arthritis: "[Start with] an individualized exercise program that strengthens the joints without causing more damage...and an eating program to control your weight if you are currently overweight." To limit the effects of arthritis, you should quit smoking, since smoking generates free radicals that can harm the tissues which make up joints. In addition, a strict vegan diet may help alleviate some of the pains of rheumatoid arthritis.
Dr. Theodosakis also recommends looking for hidden causes of symptoms, such as food allergies, that may contribute to arthritis.
Heat helps ease arthritis pain and encourages both blood flow and tissue repair. A plain, old-fashioned hot water bottle works quite well. Or you can use one of the newer heat-generating wraps, which are thin enough to be worn under clothing and don't have to be constantly reheated.
You can't always avoid arthritis, especially as you get older. But you don't have to let it get the better of you.
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Immunity - The Big Picture
June 10, 2005 09:51 PM
Author: Darrell Miller
Subject: Immunity - The Big Picture
Immunity: The Big Picture by Brian Amherst Energy Times, August 3, 1999
Your body wants to be well. Outfitted with a battalion of defenses for strategic deployment, your immune system explodes with resistant force at the first sign of infective invasion.
Think of the time a tiny splinter embedded itself in your thumb. By bedtime, the spot rose and reddened; by morning, white blood cells had launched their campaign, building a hot, throbbing fortification. By day's end, the bit of wood was propelled to the surface and ejected by the immune system warriors. Once again, a foreign assailant was summarily ousted.
The Protective Force
The immune system is a dazzlingly complex mechanism charged with guarding against infection, colds, flu and cancer. Laced with networks of couriers and transmitters, backed up by intricate fail safe devices and reinforced by memory units, immunity constantly adapts to highly specific and evolving needs.
"Supporting the immune system is critical to good health. Conversely, good health is critical to supporting the immune system." So write naturopathic doctors Michael T. Murray and Joseph E. Pizzorno in their Encyclopedia of Natural Medicine (Prima).
Maintaining the immune system requires a comprehensive program of wholesome diet, resilient attitude, fitness enhancing activity and nutrients keyed to the clear and specific needs of this energetic machine.
The all-star lineup for immune sustenance: a high-potency multiple vitamin/mineral formula, vitamins C and A, bioflavonoids, isoflavones, zinc and selenium, antioxidants like ActiVin (grape seed extract) and pycnogenol (French maritime pine bark), as well as the botanicals echinacea and astragalus.
But optimal partnering with your immune system also benefits from understanding its workings.
The immune system wages war on the organ, tissue and cellular fronts. It encompasses the lymphatic vessels and organs (lymph nodes, thymus, spleen and tonsils), white blood cells, specialized cells in particular tissues and customized chemicals.
Lymph, a milky fluid consisting of water protein and immune cells, is the essence of the immune system. Powered by muscle movement (an important reason why exercise boosts immunity), the lymphatic system collects and transports lymph to the lymph nodes. These nodes contain certain immune cells and filter out invading antigens, as well as produce antibodies, before siphoning the lymph out into the bloodstream.
If you've ever had "swollen glands," that means your lymph nodes have been in overdrive.
Macrophages are the immune cells that filter lymph, consuming bacteria and cellular debris while protecting the lymph system from invasion and damage.
Two organs dominate immune function: n The thymus. The most influential, critical gland of the immune system, located just below the thyroid gland and above the heart; produces T lymphocytes, white blood cells responsible for cell-mediated immunity not controlled by antibodies. This immune response is tailored to specific antigens and is vital to resisting infection from mold-like bacteria including yeast, fungi, parasites and such viruses as Epstein-Barr, herpes simplex and hepatitis. It also protects against cancer, allergies and autoimmune disorders like rheumatoid arthritis. n The spleen. The largest mass (about seven ounces) of lymphatic tissue in the body, located in the upper left abdomen behind the lower ribs; it produces white blood cells, which engulf and destroy bacteria and cellular debris; recycles material from worn out red blood cells and platelets; produces immune system enhancing compounds, including the proteins tufsin and splenopentin, and spleen extracts.
The White Blood Cell Album
Although white blood cells (WBCs) are uniformly accountable for protecting the body against bacteria, viruses, fungi and parasites, the different types of WBCs vary considerably in form and function. n Neutrophils phagocytize, that is, eat, viruses, bacteria and old or dead cells. They don't need any biochemical messengers for activation and their effectiveness is wide-ranging.
In Monocytes collect cellular trash after infections and can trigger immune responses; eosinophils can eliminate foreign particles and, with basophils, are involved in immune response.
In Lymphocytes include varieties of T cells, which work with other white blood cells or attack and destroy foreign tissue, cancer cells or virus-infected cells; B cells that produce antibodies that bind to bacteria, viruses or tumors; and natural killer cells (NKCs) that destroy cancerous or virally-infected cells.
(Based on information in the Encyclopedia of Natural Medicine; The Road to Immunity: How to Survive and Thrive in a Toxic World (Pocket Books) by Kenneth Bock, MD, and Nellie Sabin; and the Johns Hopkins Family Health Book (Harper Resource).
Keep the System Sound
Your immunity mechanism calls for special care and support. The dilemma: How to develop a balanced system of complementary and alternative therapies to build and sustain powerhouse immunity? "There is no question that, in terms of immune system response, certain supplements can reduce infections, asthma, autoimmune disease and risk factors for cancer," says Samuel D. Benjamin, MD, former project director of the Arizona Center for Health and Medicine and an ardent advocate for complementary medicine.
"But you must always be sure to maintain the mind-body-spirit link," he told Energy Times. "For the mind, it could be exercise, yoga or meditation. Evidence shows improved immune system responses from these therapies. And in any case, you never read in the headlines that somebody has been admitted to the emergency room overdosing on meditation.
"Intentionality also is an important part of the mind link: believing you are going to fare well. For your spirit, you must ask yourself such questions as, Do I feel connected to others?
"For the body, a daily multivitamin and mineral supplement. Much depends on your community: I live on Long Island, where there is a high incidence of breast cancer, so I would recommend green tea and isoflavones from soy products for women."
Dr. Benjamin stresses moderation in the use of immune-intensifying supplements, among which he cites mixed carotenoids, zinc and vitamin E.
The Soy Solution
Scientists who took the cue from the apparent link between high-soy Asian diets and low cancer incidence have developed a compelling case for soy as an immune-supportive anticancer agent.
In a study conducted by the University of Southern California at Norris and published in the March 4, 1998 Journal of the National Cancer Institute, researchers reported that genistein, an active component of soy products, short-circuits the ability of tumor cells to elude destruction by the immune system due to an excess of defensive stress proteins.
Genistein seems to make cancer cells vulnerable to the immune response. Researchers at Wake Forest University told participants at the January 1999 meeting of the American Association for the Advancement of Science that dietary or supplemental soy fed to monkeys counteracted cell proliferation that is a cancer precursor.
That Championship C
Probably the most widely recognized immune accelerator is vitamin C, an honored warrior against scurvy and, in 1970, again celebrated by Linus Pauling for its preventive powers over the common cold.
Immune cells are known to accumulate and retain high levels of vitamin C. Researchers at Memorial Sloan-Kettering Cancer Center in New York now understand how that happens: Proteins called growth factors (which control growth and production of immune cells) also increase those cells' ability to take up vitamin C.
These researchers, reporting in the April 1998 issue of the journal Blood, explain that the additional glucose that the growth factors pump into immune cells (for enhanced energy), plus extra vitamin C, intensify immune response.
And folks with higher levels of vitamin C in their blood serum experience less cell damage from free radicals that leads to cancer, heart and pulmonary disease and other chronic conditions.
Scientists at the University of Buffalo (addressing the June 13, 1997 meeting of the Society for Epidemiologic Research) deduced from studying population groups that high levels of vitamin C are associated with low oxidative stress and lower risk of cell damage.
From A to Zinc
In Kids with neuroblastoma, a malignant tumor of embryonic nerve cells and the third most common form of childhood cancer, experienced significantly improved survival rates when their therapy included high doses of retinoic acid, a derivative of vitamin A, according to researchers at the University of California, San Francisco, and Childrens Hospital Los Angeles, who reported to the American Society for Clinical Oncology on May 18, 1998.
In Colostrum, the pre-milk liquid produced by mammals during the first 24 to 48 hours after birth, took the spotlight recently as a supplement imbued with multiple immune factors and natural antibiotics that augment body's immune response. A 1992 study showed that bovine colostrum might be able to reduce and prevente infections in immune deficient folks, especially those with AIDS.
In University of Pittsburgh Cancer Institute researchers found for the first time (on laboratory animals) that vitamin D appreciably inhibits widespread prostate cancer by binding to cancer cells and triggering cell death or their transformation to benign cells.
In Vitamin E exerts formidable immune-enhancing influence on both antibody and cell-mediated immunity. One fundamental study in the Journal of the American Medical Association (245, 1981: 53-58) established conclusively that vitamin E deficiency results in significant impairment of immune function. Later studies demonstrated that it reduces prostate cancer by up to one-third.
In Coenzyme A, described as a metabolic enzyme, takes part in starting numerous body processes that provide energy for the immune system. If you ever run short of this enzyme, fat processing within your body would grind to a halt.
in Researchers looking at a substance with the tongue twisting name 3-acetyl-7-oxo-Dehydroepiandro-sterone, believe it aids immunity by quelling stress hormones.
in Mushrooms contain natural substances called polysaccharides, believed to enhance immunity. In particular, maitake mushroom, which conveys the immune booster beta-D-glucans, is reputed to help fight infections and drop blood pressure.
in Men and women taking selenium supplements for 10 years had 41% less total cancer than those taking a dummy, according to a January 1997 study by Cornell University and the University of Arizona. Other studies have shown it to reduce the risk for colon cancer by about 60%. n Zinc may provide immediate protection against the all too common cold. Scientists at the University of Florida were the first to apply genetic fingerprinting methods like those used in criminal and paternity investigations to understand how nutrients directly affect human immune cells.
The study, in the April 1998 Journal of Nutrition, demonstrates that zinc signals cells to make the protein metallothionein, which protects against infections, toxins and other stressors.
Phytochemicals a la Carte
Researchers extol the powers of phytochemicals in fruits and vegetables available in dietary or supplement form as immune-igniting antioxidants. These compounds neutralize free radicals that oxidize cellular membranes, rendering them vulnerable to cancer.The Strang Cancer Prevention Center, an affiliate of New York Presbyterian Hospital, offers a menu of the top antioxidant phytochemicals. The center's director, Mitchell L. Gaynor, MD, is coauthor (with Jerry Hickey, RPh) of Dr. Gaynor's Cancer Prevention Program (Kensington): n Carotenoids, including beta-carotene from veggies and lycopene (the substance that lends the tomato is ruddy complexion), fight free radicals.
n Isoflavones from soy, fight angiogenesis, the process by which new blood vessels form to supply nutrients to cancerous growths. n Sulforaphane in broccoli, kale and cabbage activates anticancer enzymes.
n Omega-3 fatty acids in cold water fish block the synthesis of prostaglandins, natural compounds in the body that promote tumor growth.
n Ginger contains antioxidant compounds, each more potent than vitamin E. Recent studies on mice show ginger can prevent skin tumors. n Rosemary contains carnosol which deactivates carcinogens and helps limit the effects of prostaglandins.
Sometimes the world can look like a dangerous place, especially when you're sick and tired much of the time. But in the search for immunity, menus of health help like this ensure that no matter what your immunity needs, a boost can be yours with the proper nutrient selection.
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St. John’s Wort - Natural Solutions For A Positive Outlook
June 06, 2005 08:59 AM
Author: Darrell Miller
Subject: St. John’s Wort - Natural Solutions For A Positive Outlook
Stress, tension and anxiety are common in our fast-paced environment. The need for a safe, natural alternative to help one maintain a positive sense of well-being has never been greater. St. John’s wort, a traditional European botanical, is now being upheld by modern science as having uniquely beneficial constituents for supporting a positive outlook. Planetary Formulas offers you four St. John’s wort formulas. Each offers the modern consumer time-tested herbal supplementation, formulated in light of the latest advances in scientific research.
Modern Research Validates Traditional Use
St. John’s wort, in use since the middle ages, is native to Europe but is now found throughout North America. Most modern research into the properties of St. John’s wort has been conducted in Germany, where the use of this herb is widespread. In 1994, almost 66 million daily doses of standardized St. John’s Wort extract were dispensed in Germany. Clinical interest in St. John’s wort reached new heights in 1996, when the British Medical Journal published a summary of research findings, concluding that it had a beneficial effect on mental well-being.
The key constituents of St. John’s wort include naphthodianthrones (hypericin and pseudohypericin), a broad spectrum of flavonoids, and phloroglucinols (especially hyperforin and adhyperforin).
An Array of Botanical Formulas
Planetary Formulas’ St. John’s wort family is available in four exceptional forms: ST. JOHN’S WORT EXTRACT tablets are standardized to consistently yield 0.3% hypericin. Three tablets, the suggested use, contain 900 mg of St. John’s wort extract, yielding 2.7 mg hypericin. This is the characterization of products found in studies to support a positive outlook and overall sense of well-being.
FULL SPECTRUM™ ST. JOHN’S WORT EXTRACT combines standardized hypericin extract (0.3%) with a flavonoid-rich (4:1) concentrate of flowering tops, in order to capture the broadest array of constituents associated with St. John’s wort’s positive effects. Each tablet yields a minimum of 1.0 mg of pure hypericin, a marker reflective of St. John’s wort quality, along with valuable secondary consituents.
FULL SPECTRUM™ ST. JOHN’S WORT LIQUID EXTRACT. This leaf and flower extract is rich in the broad spectrum of St. John’s wort constituents, which are reflected in its deep burgundy color. It is at least twice as strong as a typical tincture.
ST. JOHN’S WORT EMOTIONAL BALANCE™ unites a standardized St. John’s wort extract with Chinese herbs from the classic formula Xiao Yao Wan, or “Relaxed Wanderer,” and with the Western herb, lemon balm (Melissa officinalis), historically used to raise spirits. Planetary Formulas St. John’s wort supplements integrate modern biochemistry with traditional wisdom. The result is a positive and balanced approach to mental well-being, backed by the 30 years of experience of renowned author, herbalist and acupuncturist, Michael Tierra, L.Ac., O.M.D.
Johnson, D. et al. 1992. TW Neurologie Psychiatrie:6. 436-444. Johnson, D. et al. 1994. J Geriatr Psychiatry Neurol:7 (Suppl 1):S44-6. Linde, Klaus, et al. 1996. Brit Med J, 313:240-58. Meruelo, Daniel et al. 1988. Proc Natl Acad Sci, 85:5230-4. Schulz, M. & M. Jobert, 1994. J Geriatr Psychiatry Neurol:7 (Suppl 1):S39-43.
VitaNet ® Staff
Positive Thought - Balance Emotions and Mood...
June 04, 2005 01:34 PM
Author: Darrell Miller
Subject: Positive Thought - Balance Emotions and Mood...
As modern life becomes increasingly stressful, people are seeking out natural products that promote calmness and relaxation. But unless your supplement addresses multiple body systems, a healthy positive outlook may be out of reach. POSITIVE THOUGHTS Bio-Aligned Formula supports the interrelated systems and functions involved with emotional balance: inhibitory, stimulating and balancing neurotransmitters, and energy metabolism. This comprehensive herbal-nutrient blend features St. John’s wort, which has been clinically shown to support a good mood.
A Bio-Aligned Formula™
POSITIVE THOUGHTS is designed to bring alignment to the multiple, interconnected systems that influence a positive mood. Here’s how:
Neurotransmitters are brain chemicals that aid in the process of nerve cell communication. Inhibitory neurotransmitters, such as GABA, reduce brain stimulation, helping to support a sense of relaxation and calm. The nerve cell membrane- stabilizing properties of taurine also support relaxation, as do the included herbs. In addition to supplying GABA and taurine, POSITIVE THOUGHTS supports inhibitory neuro-modulation with kava, lemon balm, valerian, and vitamin B-6.
Stimulating neurotransmitters help promote drive, ambition, alert mental functioning, and memory. They support a positive mental outlook by providing a feeling of energy and vitality. POSITIVE THOUGHTS supports stimulating neuromodulation with DMAE, L-phenylalanine, L-tyrosine, N-acetyl-L-tyrosine, and vitamins B-5 and B-6.
In our high-powered, stress-filled world, the balancing properties of St. John’s wort can help maintain a positive outlook and a sense of well-being. Studies have shown that St. John’s wort can help support a positive mood.
Acetylcholine is one of the most important neurotransmitters in the brain. It is vital for memory, cognitive function, focus, concentration, and muscle movement. POSITIVE THOUGHTS contains DMAE, vitamins B-1, B-5 and B-12, and pantothenic acid to support acetylcholine production.
The brain’s energy supports the vast electric, chemical, and structural processes that are the basis of a positive outlook. The brain uses 60% of the glucose used by the body at rest. Nutrients help convert glucose to the energy that the brain requires. They are also a component of many coenzymes needed for the synthesis of key neurotransmitters. POSITIVE THOUGHTS addresses energy metabolism with these nutrients: magnesium, manganese, zinc, vitamins B-1, B-2, B- 3, B-5, B-6, B-12 and C, biotin, and folic acid.
Strategies for WellnessSM: A Healthy Mood Plan
Lifestyle choices can help you maintain a positive attitude in response to the normal stresses of everyday life. • Simplify Your Life: Is it important to have a luxury car or a large house? If so, you will have to work long hours and worry about making ends meet. How important are all the activities in your busy schedule? Choose one or two you truly enjoy and reevaluate your commitment to the others. • Eat Well: Anxiety drains your energy, so it is important to nourish your body in the face of stress. Eat fruits, vegetables, whole grains, and highprotein foods, and consider taking nutritional supplements. What you eat can influence your mood—keep track of which foods help or hinder you. Avoid excessive caffeine, alcohol and sugar, which raises energy in the short term but leads to depleted energy over time. • Get Active: Exercise improves blood flow to your brain, and helps release “feel good” chemicals called endorphins into your blood stream. Physical activity also takes your mind off your troubles and helps you focus on things outside yourself. • Meditate: This effective relaxation method can divert your mind from problems, give you time to recuperate, and help with clear thinking, focus and concentration. It also slows your breathing, allowing your lungs to fill with fresh oxygen—your body’s fuel—and to release waste products. • Express Yourself: Keeping a journal is a great way to think about what upsets you and how it can be changed. Artistic expression—drawing, painting, or sculpting—may help reconcile inner conflicts and foster self-awareness. Dance or movement therapy may be your preferred mode of expression, especially for gaining a sense of ease with your body. Or music may help you relax or feel upbeat. • Share Your Feelings: Develop supportive relationships—just talking to friends or family, even without finding solutions, can help you feel better. And you may get insights that help you articulate what you are struggling with. Know when to seek professional help if problem become overwhelming.
Neuro-Modulation—Inhibitory: GABA, Kava Kava, Lemon Balm, Taurine, Valerian, Vitamin B-6
Neuro-Modulation—Stimulating: DMAE, L-Phenylalanine, LTyrosine, N-Acetyl-L-Tyrosine, Vitamins B-5 & B-6
Neuro-Modulation—Balancing: St. John’s Wort
Acetylcholine Production: DMAE, Vitamins B-1, B-5 & B-12, Pantothenic Acid
Energy Metabolism: Magnesium, Manganese, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6, B-12 & C, Biotin, Folic Acid
Johnson, D. et al. (1994). J Geriatr Psychiatry Neurol:7 (suppl 1), S44-S46. Johnson, D. et al. (1992). TW Neurologie Psychiatrie:6, 436-444. Leathwood, P.D. et al. (1982). Pharmacology Biochemistry & Behavior:17, 65-71. Sabelli, H.C. (1986). J Clin Psychiatry:47(2), 66-70. Schulz, H. & Jobert, M. (1994). J Geriatr Psychiatry Neurol:7 (suppl 1), S39-S43. Wurtman, R.J. et al. (1974). Science:185, 183-184.
VitaNet ® Staff
Heart Science - A Five-Tiered Approach to Heart Health ...
June 02, 2005 12:07 PM
Author: Darrell Miller
Subject: Heart Science - A Five-Tiered Approach to Heart Health ...
Heart Science 30 tabs
Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.
Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health
Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
1) generating energy,
2) decreasing harmful homocysteine levels,
3) fighting oxidized cholesterol,
4) maintaining the heart’s electrical rhythm, and
5) protecting artery and capillary linings.
Energy Generators for An Energetic Organ
Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.
There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.
CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10
Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.
Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21
HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.
B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.
The Dangers of Oxidized LDL Cholesterol
While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.
When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.
The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.
Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.
Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits: • Beta Carotene, a plant pigment, is the naturally occurring precursor to Vitamin A. When the body takes in high enough amounts of Beta Carotene, this lipid-soluble free radical scavenger concentrates in circulating lipoproteins and atherosclerotic plaques, where it performs its antioxidant functions. Beta Carotene is particularly unique and powerful as an antioxidant because it is capable of trapping a very toxic form of di-oxygen, called singlet oxygen, which can result in severe tissue damage. Beta Carotene is one of the most efficient quenchers of singlet oxygen thus far discovered. Six tablets of HEART SCIENCE provide an unprecedented 45,000 IU of Beta Carotene! • Vitamin C is found in plasma, the watery component of blood, where it functions as a potent antioxidant. In addition to strengthening artery linings through collagen manufacture, Vitamin C is involved in the regeneration of Vitamin E within LDL particles. Vitamin C also plays an important role in the conversion of cholesterol into bile acids by the liver, a crucial step in reducing blood cholesterol levels. Once converted into bile acids, and then into bile salts, cholesterol can be excreted from the body, preventing build-up. Supplementation with Vitamin C may lower levels of LDL cholesterol and increase those of HDL cholesterol.25 It may also have a part in actually removing cholesterol deposits from artery walls — good news for people who are already experiencing plaque buildup.25 Each daily dose of HEART SCIENCE provides 1,500 mg of Vitamin C in its bioactive mineral ascorbate form. • Vitamin E, together with Beta Carotene, protects lipids from free radical attack. It is the major antioxidant vitamin that is carried in the lipid fraction of the LDL particle, where it protects the LDL particle from damaging oxidation. Within an LDL particle, one molecule of Vitamin E has the ability to protect about 200 molecules of polyunsaturated fatty acids from free radical damage! Vitamin E also aids in protecting the heart by interfering with the abnormal clumping of blood cell fragments, called platelets, within blood vessels.4 It has been shown to inhibit the formation of thromboxanes and increase the production of prostacyclins, which together decrease abnormal platelet aggregation.11 A high potency of Vitamin E — 400 IU’s — is included in six tablets of HEART SCIENCE in the natural d-alpha succinate form, recognized by scientific researchers to be the most absorbable form! • Selenium is an important mineral which has only recently gained attention. When incorporated into the enzyme Glutathione Peroxidase, it has highly powerful free radical-scavenging abilities, and has been shown to work synergistically with Vitamins A, C, and E. An essential mineral, Selenium used to be derived from eating foods grown in Selenium-rich soil. However, modern agricultural practices have depleted soil of its natural Selenium content, leaving many Americans deficient in this vital nutrient. Several epidemiological studies show that the incidence of advanced fatty deposits in blood vessels is much greater in individuals living in geographic areas of the United States and other parts of the world where the Selenium content of the soil is very low.27 • Proanthodyn,™ an extract of grape seeds, is being called the most powerful antioxidant yet discovered. This highly potent, water-soluble bioflavonoid contains between 93-95% proanthocyanidins, the highest concentration of any nutrient available today. The protective actions of proanthocyanidins may help to prevent the development of plaque in artery walls by inhibiting the free radicals which are produced during the oxidation of cholesterol. The optimal daily amount (100 mg) of Proanthodyn is included in six tablets of HEART SCIENCE. In addition to the protective actions of antioxidants, several other nutrients can contribute to healthier cholesterol ratios. • Chromium is a trace mineral which functions to aid the entrance of glucose into cells. Six tablets of HEART SCIENCE provide 300 mcg of Chromium in the form of Chromate® Chromium Polynicotinate and Chromium Picolinate — the most bioactive forms of Chromium. Not many people are familiar with the vital role Copper plays in the body. This trace mineral is found in all tissues of the body, and is particularly concentrated in the heart. Copper is part of several enzymes, and, in this capacity, is necessary for the development and maintenance of the cardiovascular system, including the heart, arteries, and other blood vessels. Because of its role in elastin production, Copper deficiency can severely damage blood vessels and heart tissue. In fact, researchers have found an inverse relationship between Copper status and increased risk for heart damage.10 • L-Proline and L-Lysine are two natural amino acids which show exciting promise in helping to prevent fatty deposits in blood vessels. Researchers have recently identified a particle associated with LDL called apoprotein (a) which is believed to be a main culprit in plaque development. 17 Scientific investigation has revealed that the lipoprotein (a) particle has an adhesive quality that makes the lipoprotein fat globule stick inside blood vessels. The sticky fat globules accumulate, leading to fatty deposits in blood vessels and the subsequent clogging of the arteries. L-Proline and L-Lysine tend to form a barrierlike layer around the apoprotein (a) particle, helping to push it away from the blood vessel wall, and impeding deposit.21
The Regulating Trio
Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings. • Magnesium is one of the single most important nutrients for maintaining a healthy heart. It plays an extremely vital role in maintaining the electrical and physical integrity of the heart muscle. It has been well established that Magnesium deficiency predisposes humans to serious disruptions of normal cardiac rhythm. One theory is that because Magnesium has a relaxing effect on muscle tissue, inadequate Magnesium stores may make the coronary arteries more susceptible to muscle spasm.10 Too little Magnesium can cause a Calcium/Magnesium imbalance, which can lead to the influx of too much Calcium into heart cells, and potentiate spasms in heart tissue. Another point for consideration is that because it relaxes the blood vessels, Magnesium keeps these vessels open, allowing for maximum blood flow to the heart. Magnesium also has the unique ability to stop unnecessary blood clotting by helping to reduce platelet adhesion.31 Blood clots are naturally produced by the body as a protective device to stop excessive blood flow when the body is injured. The clotting response happens when the body senses that the normally smooth blood vessel linings are rough, indicating that there is a cut. However, sometimes the body mistakes the rough surface of plaque-covered arteries as cuts, and creates unnecessary blood clots. Or, if a high fat meal has just been eaten, tiny fat globules called chylomicrons enter the bloodstream and can cause platelets to become abnormally sticky, possibly creating clots. When these clots flow through the bloodstream and reach a part of the artery which has plaque buildup, normal blood flow is blocked, and the amount of blood which reaches the heart is severely compromised. Magnesium is also crucial for the entrance of Potassium — a key mineral for many bodily functions — into the cells. Even if the body’s Potassium stores are high, without enough Magnesium, the Potassium will not be able to enter the cells and be utilized by the body. 300 mg of Magnesium (75% of the U.S.RDA) are contained in each daily dose of HEART SCIENCE. Along with Magnesium, Potassium helps to regulate normal heartbeat and blood pressure, and is necessary for the contraction and relaxation of muscle tissue. Potassium and Sodium are present in all body fluids; Potassium is found primarily within cell fluids, while Sodium is usually present in fluids surrounding cells. Together, they function to maintain the normal balance and distribution of fluids throughout the body. The body ideally should have a Potassium/Sodium balance of about 1:1; however, because the body holds onto Sodium, yet eliminates Potassium quickly, it is important that the dietary ratio of these two minerals be at least 3:1. Unfortunately, the typical American diet, with its emphasis on processed, salty (Sodiumrich) foods and lack of fresh fruits and vegetables, severely alters the body’s natural Potassium/ Sodium balance. Diets in the United States are extremely high in Sodium — sometimes containing as much as 15 times the recommended daily intake! A high Sodium/low Potassium diet interferes with the normal regulation of heartbeat and blood pressure, and has been linked with elevated blood pressure.25 Taurine is an amino acid which helps normalize electrical and mechanical activity of the heart muscle by regulating Potassium flux in and out of the heart muscle cells.
Artery Lining Protectors
Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6
Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.
The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.
Source Naturals HEART SCIENCE™
The Five Tiered Approach to Heart Health
Six tablets contain:
Vitamins and Minerals %USRDA
Pro-Vit A (Beta Carotene) 45,000 IU 900%
Vit B1 (Thiamine) 50 mg 3333%
Vit B3 (Inositol Hexanicotinate) 500 mg 2500%
Vit B6 (Pyridoxine HCl) 25 mg 1250%
Coenzyme B6 (Pyridoxal-5-Phosphate)
25 mg yielding: 16.9 mg of Vit B6 845% (Total Vitamin B6 Activity) (41.9 mg) (2095%)
Vit B12 (Cyanocobalamin) 500 mcg 8333%
Folic Acid 800 mcg 200%
Vit C (Magnesium Ascorbate) 1500 mg 2500%
Vit E (d-alpha Tocopheryl Succinate) 400 IU 1333%
Chromium (ChromeMate® †Polynicotinate-150 mcg & Chromium Picolinate††-150 mcg) 300 mcg *
Copper (Sebacate) 750 mcg 37.5%
Magnesium (Ascorbate, Taurinate & Oxide) 300 mg 75%
Potassium (Citrate) 99 mg *
Selenium (L-Selenomethionine) 200 mcg *
Silicon (From 400 mg of Horsetail Extract) 13mg *
* U.S. RDA not established.
Other Ingredients and Herbs
Coenzyme Q10 (Ubiquinone) 60 mg
L-Carnitine (L-Tartrate) 500 mg
Hawthorn Berry Extract 400 mg
Proanthodyn™ (Yielding 95 mg of Proanthocyanidins from grape seed extract) 100 mg
L-Proline 500 mg
L-Lysine (HCl) 500 mg
NAG™ (N-Acetyl Glucosamine) 500 mg
Bromelain (2000 G.D.U. per gram) 1200 G.D.U.
Taurine (Magnesium Taurinate) 500 mg
Horsetail Extract (Yielding 31 mg of Silica) 400 mg
Inositol (Hexanicotinate) 50 mg
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7. Grundy, S. M. (1993, Apr.). “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology, 16 (4 Suppl.I), I3-5.
8. Hano, O. et al. (1994, June). “Coenzyme Q10 Enhances Cardiac Functional and Metabolic Recovery and Reduces Ca2+ Overload during Postischemic Reperfusion.” American Journal of Physiology, 266(6 Pt 2), H2174-81.
9. Heineke, et al. (1972). “Effect of Bromelain (Ananase) on Human Platelet Aggregation.” Experientia V. 23, 844-45.
10. Hendler, S. S. (1991). The Doctors’ Vitamin and Mineral Encyclopedia. NewYork: Fireside.
11. Jandak, et al. (1988, Dec. 15). “Reduction of Platelet Adhesiveness by Vitamin E Supplementation in Humans.” Thrombosis Research 49(4), 393-404.
12. Jialal, I., et al. (1991, Oct. 15). “Beta-Carotene Inhibits the Oxidative Modification of Low-density Lipoprotein.” Biochimica et Biophysica Acta, 1086(1), 134-8.
13. Jialal, I. & Fuller, C. J. (1993, Apr. 16). “Oxidized LDL and Antioxidants.” Clinical Cardiology, Vol. 16 (Suppl. I), I6-9.
14. Jialal, I., & Grundy, S.M. (1991, Feb.). “Preservation of the Endogenous Antioxidants in Low Density Lipoprotein...” Journal of Clinical Investigation, 87(2), 597-601.
15. Kamikawa, T., et al. (1985). “Effects of Coenzyme Q10 on Exercise Tolerance...” American Journal of Cardiology, 56, 247-251.
16. Kosolcharoen, P., et al. (1981, Nov.). “Improved Exercise Tolerance after Administration of Carnitine.” Current Therapeutic Research, 753-764.
17. Lawn, R. (1992, June). “Lipoprotein (a) in ...” Medicine, 12-18.
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19. Nayler, W. G. (1980). “The Use of Coenzyme Q10 to Protect Ischemic Heart Muscle.” In: Yamamura Y., Folkners K., Ito Y., eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 2, Amsterdam: Elsevier/North-Holland Biochemical Press, 409-425.
20. Press, R.I., & Geller, J., (1990, Jan.). “The Effect of Chromium Picolinate on Serum Cholesterol and Apolipoprotein Fractions in Human Subjects.” Western Journal of Medicine, 152, 41-45.
21. Rath, M. (1993). Eradicating Heart Disease. San Francisco: Health Now.
22. Rossi, C. S., & Silliprandi, N. (1982, Feb.). “Effect of Carnitine on Serum HDL Cholesterol: Report of Two Cases.” Johns Hopkins Medical Journal, 150(2), 51-4.
23. Schwarz, K. (1977, Feb. 2). “Silicon, Fibre, and Atherosclerosis.” The Lancet, 454-456.
24. Selhub, J., et al. (1995, Feb. 2). “Association Between Plasma Homocysteine Concentrations and Extracranial Carotid-artery Stenosis.” New England Journal of Medicine, 332(5), 286-291.
25. Somer, Elizabeth. (1992). The Essential Guide to Vitamins and Minerals. New York: Health Media of America.
26. Stampfer, M. J., et al. (1992, Aug. 19). “A Prospective Study of Plasma Homocyst(e)ine...” Journal of the American Medical Association, 268(7), 877-881.
27. Suadicani, P., Hein, H. O., & Gyntelberg, F. (1992, Sept.). “Serum Selenium Concentration...in a Prospective Cohort Study of 3000 Males.” Atherosclerosis, 96(1), 33-42.
28. Thomas, C. L. (Eds.). (1985). Taber’s Cyclopedic Medical Dictionary, (15th ed.). Philadelphia: F.A. Davis Company.
29. Tsuyusaki, T. et al. “Mechanocardiography of ischemic or hypertensive heart failure,” in Yamaura Y et al., Biomed. & Clin. Aspects of Coenzyme Q.2 Amsterdam, Elsevier/North Holland Biomedical Press, 1980, 273-88.
30. Verlangieri, A. J., & Stevens, J. W. (1979). “L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan S Incorporation...” Blood Vessels, 16(4), 177-185.
31. Werbach, M. R. (1987). Nutritional Influences on Illness: A Sourcebook of Clinical Research. New Canaan: Keats Publishing, Inc.
32. White, R.R., et al. (1988, Jul-Aug.). “Bioavailability of 125I Bromelain after Oral Administration to Rats.” Biopharmaceutics and Drug Disposition, 9(4), 397-403.
33. Whitney, E. N., Hamilton, Nunnelly, E. M. (1984). Understanding Nutrition, (3rd ed.). St. Paul: West Publishing Company.
34. Willard, Terry, Ph.D. (1992). Textbook of Advanced Herbology. Calgary, Alberta, Canada: Wild Rose College of Natural Healing.
35. Xiang, H., Heyliger, et al. (1988, Nov.). “Effect of Myo-inositol and T3 on Myocardial Lipids and Cardiac Function in Streptozocin-induced Diabetic Rats.” Diabetes, 37(11), 1542-8.
VitaNet ® Staff
Ester E - Natural E for Cardiovascular and Antioxidant Support
June 02, 2005 09:38 AM
Author: Darrell Miller
Subject: Ester E - Natural E for Cardiovascular and Antioxidant Support
We’ve all heard of vitamin E but did you know there are many different forms of this essential nutrient? Ester-E® is a unique form of vitamin E that occurs when natural d-alpha tocopherol combines with a phosphate molecule. Vitamin E is one of the body’s chief antioxidants and the phosphate form, Ester-E®, offers advanced antioxidant protection to body cells. Vitamin E also helps maintain cardiovascular health, protects the liver from toxins, enhances circulation and supports healthy immune system function. Source Naturals ESTER-E® is a patent-protected, body-ready form of vitamin E. Make Ester-E® part of your health plan for more complete nutrition.
Vitamin E was named tocopherol, from Greek tocos meaning “offspring” and phero meaning “to bring forth,” because it was originally discovered as a nutrient essential for reproduction. Vitamin E became the name given to a group of eight fat-soluble compounds–four tocopherols (alpha, beta, gamma, and delta) and four tocotrienols (alpha, beta, gamma, and delta). It is an essential fat-soluble vitamin that naturally occurs in many foods–especially vegetable oils. In 2003, the first report of naturally occurring vitamin E phosphate was published. ESTER-E® (vitamin E phosphate) occurs when a phosphate molecule combines with a natural tocopherol resulting in a unique form of vitamin E.
Vitamin E Deficiency
Researchers previously thought that deficiencies of vitamin E were rare but a large population- based study showed that sub-optimal levels might be quite common. According to this study, African-Americans feel most of the impact, with 41% having sub-optimal levels of vitamin E in their blood, compared with 28% of Mexican Americans and 26% of whites. Optimal level refers to levels in research studies associated with cardiovascular benefits. Many people, especially African- Americans, may benefit from the extra cardiovascular support offered by vitamin E.
Antioxidant and Cardiovascular Support
Vitamin E is referred to as an antioxidant even though some forms can change into celldamaging free radicals, creating a “pro-oxidant.” Free radicals are unpaired electrons that can damage living cells and compromise the proper function of tissues and organs. Vitamin E phosphate may be the previously unrecognized form of vitamin E that allows alpha-tocopherol to be stored and transported without generating free radicals. The phosphate form of vitamin E appears to have a detergent action within the cell membrane, which creates a barrier that may keep free radicals from transferring from one polyunsaturated fatty acid to another. Until its discovery, researchers wondered how vitamin E could be both an antioxidant and an oxidizer. Antioxidants neutralize destructive free radicals and support cardiovascular health by preventing the oxidation of cholesterol. Oxidized cholesterol is an unstable molecule that damages the integrity of arteries. Preliminary studies show that vitamin E phosphate may inhibit foam cell formation in in-vitro cell cultures. Foam cells are macrophages that pick up oxidized lipids and form fatty streaks in the artery walls, contributing to plaque formation.
Nutrition for Wellness
Taking personal responsibility for your health is at the heart of the wellness revolution. At Source Naturals we are committed to bringing you the finest nutrients modern research has to offer. ESTER-E® is the newest addition to our superior line of vitamin E products designed to help you live a longer, healthier life.
Ford, E; Sowell, A. Serum a-tocopherol status in the United States Population: findings from the third national health and nutrition examination survey. American Journal of Epidemiology 150 (3):290-300. ©1999 The Johns Hopkins University School of Hygiene and Public Health. BM, Rezk. 2004. The extraordinary antioxidant activity of vitamin E phosphate. Biochim Biophys Acta 1683 (1-3): 16-21. Munteanu, A. 2004. Modulation of cell proliferation and gene expression by a-tocopherol phosphates: relevance to atherosclerosis and inflammation. Biochemical and Biophysical Research Communication 318:311-16. ©2004, Elsevier Inc. Ester-E® is a licensed trademark of Zila Nutraceuticals, Inc. Ester-E food supplement and the process of making it are covered by U.S. Patents 6,579,995 and 5,387,579. Other USA and foreign patents pending.
VitaNet ® Staff
Diet Phen - Dietary Supplement and weight Loss ...
June 01, 2005 12:36 PM
Author: Darrell Miller
Subject: Diet Phen - Dietary Supplement and weight Loss ...
Diet Phen for weight Loss
Getting slim, trim and fit is no easy task. To do it you need adequate Energy, Nutritional and Emotional Support, and a Positive Attitude. Source Naturals puts them all together in the DIET-PHEN Weight Loss Plan. The plan includes an herbal-safe nutrient formula that combines optimal amounts of St. John’s wort with synephrine and green tea extract, plus L-phenylalanine and chromium. Meet your weight loss goals the natural way. Try Source Naturals DIET-PHEN dietary supplement in conjunction with the Diet-Phen Weight Loss Plan.
THE PLAN HELPS TO:
• Increase metabolic rate. • Lose unwanted body fat. • Boost energy levels. • Build and tone muscle. • Support a positive mental attitude.
DIETING – It Starts in Your Head.
Successful dieting depends on the right mind-set: you need a positive outlook and determination. When your head is in the right place, your body may follow. That’s why the DIET-PHEN Weight Loss Plan includes natural herbs and amino acids to help support a sense of active calm.
ST. JOHN’S WORT – The CenterPeace of DIET-PHEN. In use since ancient times, Hypericum perforatum is a flowering herb highly valued for its positive influence on mental well-being. Known for its soothing effect, it seems to promote relaxation without drowsiness. Recent research has focused on the connection between hypericin (the principal phytochemical in St. John’s wort) and serotonin, a key neurotransmitter associated with mood. About 90% of your serotonin receptors are found in your brain’s emotional center, the limbic system.
SYNEPHRINE, GREEN TEA AND L-PHENYLALANINE – Energize with an Attitude! Synephrine and green tea extract are added for that extra energy needed during dieting. The brain uses phenylalanine to manufacture dopamine and norepinephrine, two neurotransmitters that play an important role in drive and determination.
ACETYL L-CARNITINE – Transporting Fat to the Furnace. Within each of your trillions of cells are thousands of tiny energy factories called mitochondria. They convert fats and sugars into metabolic energy. Acetyl L-carnitine supports this process by transporting fat molecules to the mitochondria.
THE PLAN INCLUDES A DAILY SERVING OF 3 DIET-PHEN TABLETS TO PROVIDE:
• 900 mg of St. John’s wort, the traditional herb used to support a positive mood. • 24 mg of synephrine and 300 mg of green tea extract, for energy. • 500 mg of L-phenylalanine, an essential amino acid that acts as the building block for key brain neurotransmitters that support a positive mental attitude. • 200 mcg of chromium, a trace element which may work closely with insulin to help facilitate the uptake of glucose into cells. • 50 mg of acetyl L-carnitine, the bioactive form of this amino acid involved in cellular fat transport. • 25 mg each of niacin and vitamin B-6, nutrients essential to the body’s production of serotonin.
GET STARTED WITH THE PLAN ! Get DIET-PHEN dietary supplements and the Weight Loss Plan at VitaNet health food store.
REFERENCES:• Johnson, D., et al. (June 1992). TW Neurologie Psychiatrie, 6, 436-444. • Johnson, D., et al. (1994). J Geriatr Psychiatry Neurol, 7 (suppl 1), S44-S46. • Pasquali, R. et al. (1987). International Journal of Obesity, 11, 163-168. • Sabelli, H.C. (Feb 1986). J Clin Psychiatry, 47 (2), 66-70. • Schulz, H. & Jobert, M. (1994). J Geriatr Psychiatry Neurol, 7 (suppl 1), S39-S43. • Stock, M.J. (1989). Infusionstherapie, 16, 282-284.
VitaNet ® Staff
May 13, 2005 08:38 AM
Author: Darrell Miller
Sulforaphane Stimulates the Body's Cancer-Fighting Enzymes Secret Weapon Against Cancer Found in Broccoli Sprouts
by Richard Conant, L.Ac, C.N.
The health benefits of vegetables were known historically, long before researchers began seeing a connection between vegetable consumption and cancer prevention. Over the last twenty years, evidence concerning this connection has steadily accumulated. The latest and most promising findings reveal that specific vegetable constituents—"phytochemicals" to use current scientific parlance— enhance the body's defenses against cancer.
This article will focus on one phytochemical in particular, a sulfur-containing compound called "sulforaphane." Found in Cruciferous vegetables such as broccoli, sulforaphane may prove to be one of our most powerful cancer prevention allies. Recent studies have shown that sulforaphane stimulates, or "induces," "Phase two enzymes." These enzymes are an integral part of the body's elaborate detoxification system that renders carcinogens inactive. This detoxification system turns carcinogens and other toxic substances into harmless molecules that are excreted from the body.
We need not fear carcinogens—the body is equipped to deal with them.
These findings, coupled with an appreciation of the body's ability to defend itself against carcinogens, have the potential to dramatically change the way we look at cancer and substances in the environment that "cause" cancer. We need to minimize unnecessary exposure to carcinogens, and the staggering quantity of hazardous chemicals in the environment remains an urgent health concern, for cancer and many other health problems. But, knowing the body is equipped with the means to defend itself against toxins, we do not need to fear carcinogens as perhaps we have in the past.
The natural world is full of carcinogens.
What's more, even if you eat 100 percent organic food and live in a environment free of toxic man-made chemicals, you are still being exposed to carcinogens every day of your life. Food is the primary route of this exposure. Plants, for their own defense, produce over 99% of all the pesticides in agricultural products.1 Almost all foods—in their natural state—contain tiny amounts of naturally-occurring, potentially carcinogenic chemicals.
The point is not to trivialize the concern over environmental toxins. The point is that the natural world is full of toxins that are not man-made. These substances have been around since before we appeared, which is why we have evolved with a highly efficient system for neutralizing them before they can damage our cells and initiate the complex process that produces cancer.
Broccoli sprouts are a concentrated source of cancer-fighting sulforaphane.
We cannot avoid carcinogens. What we can do is support our internal detoxification system. Sulforaphane is a powerful tool in this effort. We can start by following the often-repeated advice to eat a variety of vegetables every day, and include broccoli in our menu.
There is an even richer source of sulforaphane than broccoli itself. In September 1997, a group of scientists at the Johns Hopkins University School of Medicine made a breakthrough discovery— broccoli sprouts contain ten to one hundred times more sulforaphane than mature broccoli.2 Vegetable sprouts are generally regarded as exceptionally healthy foods. Broccoli sprouts now look like a shining star, especially when it comes to cancer prevention.
For those lacking the time or inclination to keep a fresh supply of broccoli sprouts on hand, broccoli spouts have been processed into an extract that is even more concentrated in sulforaphane. More on this later.
What have researchers learned about broccoli consumption and cancer rates?
More than 200 epidemiological studies—studies which track groups of people over time to uncover realtionships between variables such as diet and the incidence of disease—have invesitgated the connections between vegetable consumption and various forms of cancer.1 It should be understood that findings from epidemiological research are generally not regarded as conclusive; these studies are not controlled, and often use data gleaned from questionnaires, which are an imprecise method of gathering information. (In the case of diet questionnaires, for example, the study subjects may or may not record their food intakes with 100 percent accuracy.)
Epidemiological studies look for trends. To be credible, these trends need to show up consistently, in different population groups. Findings from the vegetable intake/cancer studies easily meet these criteria; the number of studies is large and the trend is consistent—vegetable consumption is strongly associated with a lower risk of developing cancer.
What about broccoli in particular? A paper published in the September 1996 issue of Cancer Epidemiology, Biomarkers & Prevention analyzes epidemiological data gathered from 94 studies concerning the cancer preventive effect of brassica vegetables.3 (The Brassica genus, part of the Cruciferae family, includes broccoli, cabbage, kale, cauliflower and brussels sprouts.) The data suggest that broccoli consumption reduces the risk of some of the most feared forms of cancer, including stomach and lung cancer.
Now, to put these data into a balanced perspective, the researchers point out that in most of the studies reviewed, brassica vegetable consumption was reported as part of the total vegetable intake. "In hardly any epidemiological studies was the effect of brassica vegetables separated from the effect of total vegetables or other vegetables by adjusting for consumption of these variables. Therefore, it is difficult to sort out whether the observed observation was attributable to brassica vegetables, to vegetables as a whole, or to other vegetables," they noted.
This uncertainty is a good example of why epidemiological studies alone do not give us open and shut conclusions. But the paper also adds that the apparent anti-cancer effect of brassica vegetables agrees with "the results of experimental studies in which brassica vegetables reduced mammary tumor incidence, hepatic tumor size, numbers of tumors per liver, tumor frequency, and the number of pulmonary metastases when given to rodents before or after a carcinogen insult."3
When you put together a plausible trend from epidemiological research with results of experimental studies that agree with the trend, and then add additional research that reveals the underlying mechanism for these observations, a clear picture begins to take shape. And, indeed, we now have a fairly good idea as to just how brassica vegetables, especially broccoli, help prevent cancer.
How sulforaphane helps prevent cancer from developing.
To see how sulforaphane works, let's look at a brief overview of the body's detoxification system.
The detoxification of carcinogens and other toxic substances takes place in the liver, and involves two distinct enzyme-driven processes or "phases". Phase one enzymes neutralize toxins by various routes. Some of these convert toxins into substances that are immediately eliminated. However, other Phase one steps convert toxins into intermediate products which are carcinogenic themselves, and require further treatment before they can be excreted. Phase two enzymes do this vital job. Phase two enzymes deactivate these carcinogenic metabolites of Phase one, and the final breakdown product is then eliminated once and for all. (For an excellent review of this subject, see Encyclopedia of Natural Medicine, by Drs. Michael Murray and Joseph Pizzorno.4)
Phase two is critical. If Phase one is in good working order, but Phase two is not, the potential threat from carcinogens increases. It is vitally important to keep Phase two operating well. This is where sulforaphane plays its cancer preventive role. Sulforaphane is a powerful inducer of Phase two enzymes.5,6
Broccoli sprouts-the ideal source of sulforaphane
Sulforaphane is one among a group of phytochemicals called "isothiocyanates." (These occur in brassica vegetables largely as "glucosinolates," which are precursors for isothiocyanates2,12 When the plant is crushed, glucosinolates are converted to isothiocyanates.) Sulforaphane induces Phase two enzymes exclusively, leaving Phase one enzymes alone. This means it helps reduce the load of carcinogenic Phase one intermediates without adding to the load by stimulating Phase one.8,9
As reported by the Johns Hopkins University research group, broccoli sprouts are an "exceptionally" rich source of sulforaphane (in the form of "glucoraphanin, sulforaphane's glucosinolate precursor). And broccoli sprouts have another advantage over mature broccoli. They contain almost no indole glucosinolates, phytochemicals present in mature broccoli that "can enhance tumorogenesis."2
Broccoli sprouts as an extract, now available as a dietary supplement, takes the concentration of sulforaphane to the next level. This recently developed nutraceutical product contains a potent 20 to 1 extract of three-day old fresh broccoli sprouts.
One 125 mg capsule supplies the same amount of sulforaphane as 125 grams, or about 5 ounces, of mature broccoli. Taking just one capsule a day is like eating two pounds of broccoli per week, which equals the intake of cruciferous vegetables believed necessary to obtain their health benefits.
1. Steinmetz, K.A. Potter, J.D. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc. 1996;96:1027-1039.
2. Fahey, J.W., Zhang, Y., Talalay, P. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. 1997; 94:10367-10372.
3. Verhoeven, D.T.H., et. al. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiology, Biomarkers & Prevention 1996;5:733-48.
4. Murray, M. Pizzorno, J. Encyclopedia of Natural Medicine. Rocklin, CA: Prima Publishing;1998:110-120.
5. Zhang, Y. Talalay, P, Cho, C., Posner, G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. 1992;89:2399-2403.
6. Gerhäuser, C. et. al. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Research 1997;57:272-78.
7. McDanell, R., McLean, A.E.M., Hanley, A.B., Heaney, R.K., Fenwick, G.R. Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Fd. Chem. Toxic. 1988;26(1):59-70.
8. Talalay, P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. in Advances in Enzyme Regulation, Vol. 28, Weber, G., Ed., 1989: Pergamon Press.
9. Prochaska, H.J. Santamaria, A.B., Talalay, P. Rapid detection of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. 1992;89:2394-98.
Broccoli Concentrate 850mg 60tb Broccoli Seeds Sprt 4 oz. Broccoli Sprouts 30tb Broccoli Sprouts 60tb Indol 3 Carbinol from Broccoli 30ct 100mg Indol 3 Carbinol from Broccoli 30ct 25mg Indole 3 Carbinol 200mg 30ct from broccoli
VitaNet ® Staff
May 09, 2005 06:10 PM
Author: Darrell Miller
It's in the Blood Natural alternatives abound for managing cholesterol levels, backed by a growing body of research ©VR By Paul Bubny
The National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen.
“The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks.
“Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).”
At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke.
While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!”
Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.”
And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.”
Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.”
King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.”
Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.
"Blur of Products"
With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.”
To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following:
Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent.
Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels.
Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.”
“The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.”
On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone.
Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients.
Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs.
Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic.
Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action.
Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.”
Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take.
“Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels.
Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids.
Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period.
“The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake.
For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.”
Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients.
Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO.
Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols.
Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol.
Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky.
“In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.”
Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.”
Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said.
However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.”
Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.”
Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols.
Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”
There are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise.
With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.”
Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM.
“Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR
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