Search Term: " L-CARN "
Study finds that a combination of L-carnitine and vitamin E canovercome immunosuppression
January 04, 2019 08:12 AM
A study has shown that L-carnitine and vitamin E taken together can boost the immune system in response to the immunosuppressing toxin ochratoxin A. The study was conducted with four groups of birds: one that was given the toxin and vitamin E, one given the toxin and L-carnitine, one given the toxin and both supplements, and one given only the toxin. Of the four, the one given both supplements together showed the most resistance to the effects of the toxin, indicating that the combination of the supplements aided the immune system.
"L-carnitine and vitamin E can improve the immune system, according to a study."
Read more: https://www.naturalnews.com/2018-12-27-combination-of-l-carnitine-and-vitamin-e-can-overcome-immunosuppression.html
Soaking 4 Almonds inThe Night & Eating Them In The Morning Would Do This To My Body In 1 Day!
May 30, 2017 05:14 AM
Almonds are healthy sources of many nutrients and they can be eaten in many ways. Stores sell almond milk, butter, flour, oil and more. You can also buy whole almonds, both shelled and unshelled, roasted and raw. Most people wouldn't think of soaking them. That's the surprising info here. What would that do for our health? This tells us. It will make you feel differently about eating almonds and about how you do so as well.https://www.youtube.com/watch?v=8PMY0Q3F-Xg&rel=0
"Prevent colon cancer: One of the best advantages of almonds is that they help you prevent the formation of cancer cells related to colon cancer."
What Is the Malibu Miracle Weight Loss Program?
If you want to shed some pounds quickly and easily, then Malibu Miracle weight loss program is what you need. The exotic berry Malibu Miracle formula produces amazing noticeable results that will get you slimming sooner than you thought. Malibu Miracle contains a blend of highly effective and concentrated blend of succulent fruits including Gogi, Noni, Mangosteen, Pomegranate and Acai. With this, you can have a wholesome nutrition that will support your body cleansing as well as experience an exhilarated state of well-being. Malibu Miracle juice is delicious and is charged with metabolism-supporting botanicals which include L-CARNitine, Super Citimax, Green Tea, Red wine, prebiotic fructooligosaccharides and Grape seed extract.
How Does The Malibu Miracle Weight Loss Program Work?
The Malibu Miracle formula contains oxygen-enhanced revitalized water that has vitality-enhancing, rehydrating and energizing properties that work naturally. That way, you can experience superior hydration, cellular health as well as an improved body health. However, when managing your weight, don’t expect miracles to happen from nowhere. It will take your hard work, determination, healthy diet and exercise program for you to realize the desired results. Malibu Miracle only serves as a supplement for a comprehensive diet and exercise program. Malibu Miracle’s line has cutting-edge formulas that will produce lightning-fast results for better living. It is amazing how you can be on your way to an improved body size and shape in as little as 48 hours. The products contain exotic natural ingredients that are combined with the latest advancements in weight nutrition. In addition to that, the Malibu Miracle juice is incredibly sweet so you have every reason to buy one for your weight loss program.
Where Malibu Miracle 48-hour juice didn’t do better, the Exotic Oxyjuice introduced Ultra Malibu Miracle. The breakthrough juice fast program comes in 6,000 mg each of real antioxidant-rich red super fruit juices ranging from Mangosteen, Noni, Goji, Pomegranate and Acai. These combination of juices kick-start the rapid weight loss in your body and also deliver nutrients which catalyze cascading full-body cleansing. On top of that, the Ultra Malibu Miracle contains Slendesta - a potato protein extract with ultimate appetite control properties- which helps you feel full and completely satisfied all day long.
All other competing juice fasting products can’t match Malibu Miracle and Ultra Malibu’s ability to deliver excellent results. These two products work great in suppressing appetite, providing anti-oxidant protection, supplying health-supporting nutrients and cutting weight within the shortest time. All that is contained in the lusciously delicious and mixed-berry juice concentrates.
Does Malibu Miracle Have Any Side Effects?
Malibu Miracle contains no artificial colors nor sweeteners. All the ingredients are naturally sourced and so you should expect minimal or no side effects while on your weight loss program. It is always advisable that during juice fasting diet, you abstain from food, alcohol, caffeine and smoking. Juice fasting is not recommended for pregnant women, lactating mothers or people with medical conditions or those that are on medication of any kind.
As with all diets, results might vary with each individual. It also depends on how much you exercise so you need to balance things out to get the desired results. However, it is important to remember that juice fasting for consecutive 48-hour periods is not recommended.
Organic Seeds and Nuts Contain Healthy Oils
One should develop a healthy habit to maintain a diet with organic seeds and nuts. Organic seeds and nuts are high in fiber, protein, Vitamin E, zinc and minerals that are required for getting a healthy and dynamic life. Numerous research and study reports say that organic seeds and nuts contain healthy oils that give an amazing result for weight loss, heart diseases and also for controlling cholesterol levels. If you are planning to include nuts and seeds in your daily diet then consider to have it in a raw form to get more healthy oils. Here are the names of some organic seeds and nut that you can make a part of your daily diet.
Almonds are considered good nuts and are used for multiple purposes. It has been used for treating different health conditions such as constipation, heart disorders, diabetes, anemia, coughs, and impotency and it works well on hair and skin. So, you must include it in your daily diet to be benefited by its natural nutrients. Almond is rich in healthy oil that is considered good for getting a long, shining hair and healthy body.
Almond is rich in riboflavin and L-CARNitine. These two nutrients are considered helpful for developing brain power. Almond strengthens the immune system and also contains important fatty acid that is required to control the level of cholesterol. Almond can be included in the diet of the people of any age group.
Cashew should be taken in the raw form to get more benefit. Cashew is rich in copper, zinc, vitamin B, vitamin E, folate and some other nutrients that are required for maintaining a healthy life. Cashew is very helpful for high blood pressure, healthy heart, healthy bone, teeth, and muscles. It has a lot of fibers and is helpful for improving your digestive system and also for curing constipation. It has healthy oils that help to lower cholesterol levels.
Macadamia nut has a sweet taste and its important nutrients are required for maintaining a healthy life. This nut has vitamin E, Vitamin A, vitamin B complex, minerals, fiber and antioxidants that are helpful for improving digestive system, managing cholesterol levels. It works well for heart diseases and has healthy omega oil that is considered good for having a healthy body and for the overall development of your body mechanism.
A perfect food for those who are looking for weight loss since Sunflower nut is rich in fiber that is helpful for improving the digestive system. Sunflower seeds should be the first choice for the women. This nut has a good amount of folate that is essential for a maintaining a healthy and energetic lifestyle. The other nutrients of Sunflower seeds are good fats, selenium and copper, vitamin E, healthy oils, and all important nutrients that are considered vital for having a healthy heart.
Organic seeds and nuts are considered good as these foods keep the body energetic and also heal the mind. Organic foods contain powerful omega oil and other healthy oil that are important for good health, healthy skin and also for the good immune system.
HEALTHY BENEFITS OF ALMOND FLOUR
January 28, 2014 08:46 PM
Benefits of Almond
Almond is considered one of the earliest domesticated tree, the tree produce the drupe consisting of a hard shell and with a seed inside. The seed is grind to make the almond flour, which is used to make different kind of recipes, almond flour, is nutritious and also high in protein, low sugar and carbohydrates. Unlike other domestically used flour, almond flour is delicious in terms of taste.
Regular and daily use of Almond flour is good for the health; here are health benefits of almond flour;
When using Almond flour, reduces the chances and reduces the risk of heart disease, the flavonoids in the almond skin works with vitamin E which act as antioxidant, where it protect the arty walls from damages.
Almonds is low in sugars and carbohydrates which are responsible to generate body fat, the almond provide healthy fats, just enough that is required by the body. Using the almond flour at least 2 times per week will help in balancing the body fat thus aid in weight loss.
Almond is naturally low on cholesterol, but contain a limited amount of carbohydrates, which is a good source of fiber, certain amount of almond contain enough calories, protein, that are capable to give you energy to go all day long.
Brain and nervous system function
Almond flour contain L-CARNitine and riboflavin nutrient, this nutrients help boost brain activities and stimulate the nervous system, they are also responsible in reducing the risk of Alzheimer’s disease. If used often the almond increase longevity and intellectual levels.
Rich in vitamin
The Almond flour is the best source of Vitamins; it contains vitamin E and vitamin B, and niacin, this vitamins support immune system and serves to protect cells against damage.
Alkalize the body
The almond flour has few protein that are able to form alkaline, this is a good course meal when you are low in alkaline, with low alkaline the body may be at risk of Osteoporosis, unhealthy weight gain and poor immune system. Almond reduce the rise in blood sugar and insulin after almond meal, the healthy benefit a lot beyond measure, if feed to the young ones, it help build strong teeth and bones.
Boost Energy With CoQ10 And L-Carnitine
November 21, 2013 08:43 PM
CoQ10 and L-CARNatine
CoQ10 and L-CARNitine offer double protection for the heart and the brain in just a single tablet. You obtain all benefits for your heart at 100% from CoQ10, while L-CARNitine supports your memory, learning ability, and focus. The exclusive combination of CoenzymeQ10 and L-CARNitine encloses an absorbable, water soluble capsule of CoQ10 and L-CARNitine, which is important for proper usage.Why are CoQ10 and L-CARNitine Supportive in Energy Boost?
CoQ10 Energy Boost
CoQ10 is a vital nutritional element found in all body cells, in particular the mitochondria, in which most energy is generated. The major function of this coenzyme is to assist in the process of oxygen and food conversion into energy. As people grow older their ability to naturally, to produce this coenzyme decays.
At the same time as Coenzyme Q10 is taking part in the production of energy in each cell of your body, it is considered be remarkably imperative for the high energy requirements of the heart. The heart needs vast energy amounts, because it is the hardest worker in your entire body. Coenzyme Q10 seems to be indispensable for this process. It offers you sufficient antioxidant provision, protecting the body cells from damage of the free radicals, and proffering a dynamic function of the immune system.
L-CARNitine Energy Boost
L-CARNitine transports indispensable fat acids into the same organ where CoQ10 plays its major function - the mitochondria. There, with the help of L-CARNitine, all fatty acids are turned into energy. However, the beneficial function of L-CARNitine does not end here. In addition, it also supports the transportation of toxins outside the body. You can think of the problems that might occur if these vital body processes are not fully operational. At the same time however, the major impact of L-CARNitine over the body is directed towards the brain:
Health Benefits Of Taking L-Carnitine
November 04, 2013 07:18 PM
What is L –Carnitine
L –Carnitine is an amino acid that is naturally produced in the body. It is found in two different amino acids; methionine and lysine. Dietary sources of this amino acid include pork, beef and small amounts of milk, chicken and fish. This amino acid is highly required by the body and the following are the health benefits of Carnitine.
Important in the management of heart conditions
Carnitine is important in the management of a number of heart related conditions for example congestive heart failure, diphtheria, chronic chest pain, heart attack and high cholesterol. Studies show that Carnitine indeed is helpful in dealing with a number of heart related diseases.
Boosts overall brain function
A recent study shows that Carnitine aids in the recovery of stroke among animals. This clearly shows that this amino acid targets the brain cells. It contains nutrients that are highly required by the brain to function properly for example vitamins E, B-12 alpha-lipoic acid and folic acid.
Helps in burning body fat
Carnitine is a portent fat burner. It is needed in the transportation of fat into cells which will be used for the production of energy in the body. When the Carnitine levels are increased in the body, the body increases the fat burning process and then boosts energy levels in the body.
This amino acid can prevent diabetes and promotes cardio vascular health. With its antioxidant properties Carnitine eliminates free radicals and also reduces oxidative stress. This is very important in the improvement of your insulin health and also help in fat loss.
Improves male fertility
Studies show that adequate Carnitine levels in the body are necessary for male fertility. According to the study fertile males had adequate levels of this amino acid it was associated with healthier sperm. While the others who were considered infertile had compromised sperm health and lower Carnitine levels.
Carnitine Heart Energy!
November 24, 2012 10:56 AM
An Amino Acid
Carnitine is an amino acid that our body manufactures for the purpose of carrying fatty acids into cells so that these acids are converted to energy. Before you begin to lose interest from the scientific sentence that you just read, here's what Carnitine does, simply put - it helps your body create energy.
Improve Heart Energy!
Carnitine is more commonly known as L-CARNitine, and since it does help your body creates energy, it has been extensively researched and scientists have come to the conclusion that using L-CARNitine as a supplement will help your heart improve its functioning and thus reduce the risk of heart disease. Although it sounds too good to be true, it is a scientific fact and has been proved by numerous studies. For people who are already suffering from any kind of heart disease, L-CARNitine, used in tandem with other prescribed medication can help by increasing the effects of the medication by quite a large amount, and making the heart function effectively and treating any disease symptoms that the patient might have. To be more specific, it helps the heart from conditions that result in lower blood supply to the heart, like angina pectoris, myocardial infarction and cardiac arrest.
It can thus be seen that Carnitine not only helps improve heart energy, but can also be life saving by removing these deadly conditions. For those who wish to make the most of Carnitine's heart friendly benefits, it is widely available as a nutritional supplement, and one does not need a prescription to get it. However, like with any supplement, it must be used in moderate amounts, as per the recommended dosage, it is impossible to overdose but taking more does not mean it will work better..
Although no conclusive bad effects have been linked to this supplement use, it is always better to be safe than sorry, and by using Carnitine wisely, you can improve your heart energy and keep it in prime shape.
What Is L-Carnosine And What Does It Do?
March 30, 2012 08:28 AM
What Is L-CARNosine
L-CARNosine is basically a combination of 2 vital amino acids-L-histidine and beta-alanine. It is naturally present in the body, mainly in the muscle, and in many animals too. Carnosine can be broken down easily into the two amino acids, but it is good to know that these amino acids work much better when combined to form L-CARNosine. L-CARNosine has the remarkable ability to revitalize, that is, to make older cells younger and lengthen their life cycle. This compound is commercially available and is the only one that has the rare and distinctive ability to rejuvenate cells.
What does L-CARNosine do?
In simple language, L-CARNosine is able to transform itself into so many compounds with each performing or enhancing a number of crucial body functions such as:
May bind to dangerous metal compounds to make them inactive.
Turning the resultant metal compound/carnosine into useful antioxidants which in turn can be anti-ulcer agents
Protecting and stabilizing cell membranes, keeping cells safe from dangerous free radicals
Protecting healthy cells from damage caused by radiation
Enhances blood flow to the brain
Acts like a neurotransmitter, helping messages move from one nerve to the other. This helps fight dementia, as in Alzheimer's disease and Parkinson's disease, and boost memory.
Blocks guanylate cyclase activation, an enzyme associated with cancer, migraine, asthma, and septic shock.
Special derivatives of carnosine can help get rid of the accumulation of sugar compounds and abnormal protein in the eye. A variety of these compounds may cause glaucoma, cataracts, and macular degeneration.
Carnosine works like a catalyst to boost the work of so many other compounds and nutrients.
Benefits of using L-CARNosine
Although L-CARNosine benefits haven't been extensively researched, according to initial studies it may help in:
Dealing with complications related to cataracts, diabetes, neuropathy, and kidney failure.
It may also help in slowing down aging in skin, minimizing wrinkles as well as breakdown of elasticity in skin.
It can help to prevent joint inflammation, atherosclerosis, and formation of cataract.
Carnosine has been known to prevent and reduce cell damage occasioned by beta amyloid-the substance found in Alzheimer's patent's brain.
Additionally, carnosine appears able to help get rid of the helicobacter pylori bacterium, the organism associated with stomach cancer and peptic cancer. Therefore, it can significantly help protect and heal both peptic and gastric ulcers.
Other possible L-CARNosine benefits
Increase muscle endurance and strength
Improves heart function
Speeds healing of wound
A powerful antioxidant that can deal with even the worst free radicals
Reduces inflammation and boosts immunity
It helps pull out or chelate some heavy metals from your body
May help autistic children
Act as anti-cancer agent in the body
Stabilizes cell membranes and slows down lipid peroxidation to protect the process of aging of the brain
L-CARNosine can help in preventing or even treating age-related conditions like:
Cell aging/cellular senescence
Cross-linking of eye lens
Build up of damaged proteins
Brain circulatory deficit
Cross-linking of collagen in the skin
DNA chromosome damage
LDL cholesterol oxidation
Formation of AGEs i.e. advanced glycation end-products.
What is stopping you from taking L-CARNosine today?
What Are The Health Benefits Of L-Carnosine?
February 28, 2012 07:53 AM
Among the numerous natural compounds in the body, L-CARNosine is also one such beneficial compound that is naturally contained in the human body. Numerous health benefits are offered by this compound, and it plays an integral role in maintaining the wellness of an individual. However, as people begin growing old, are frequently stressed or have undergone some sort of a trauma, then the levels of this compound in the body are decreased.
What is L-CARNosine?
This compound is basically a dipeptide that comprises of alanine and histidine, which are two different types of amino acids. The brain, heart, kidneys, muscles, skin and the stomach are the organs where L-CARNosinecan be naturally found. Due to its potent antioxidant traits, this dipeptide is regarded as an effective anti-aging agent.
What Are The Health Benefits Of L-CARNosine?
As mentioned, Carnosine is an integral dipeptide in the body and quite an array of benefits are offered by it.
Due to the intense antioxidant qualities of L-CARNosine, the free radical damaged caused within the body is minimized. Free radicals are not good for the cells present in the body since they damage and kill cells, and can also alter DNA too. Thus, Alzheimer's disease, heart disease, cancer and skin damage, are some of the health problems people can suffer from as a result of altered DNA, damaged and dead cells due to free radicals. In comparison to vitamin E, this compound can protect cell membranes from oxidation more effectively because it is water-soluble.
Other Carnosine Benefits
The compound also helps in healing wounds as well. The connective tissues in the body are effectively repaired thanks to the antioxidant qualities of Carnosine, and the skin is ideally healed. The compound also helps reducing the risk of wound infection too.
Cataracts and other eye conditions can also be relieved with the help of the health benefits offered by this compound. Even though this compound is naturally contained in the eye, however, as people get older, its amount lessens. Thus, primary and mature senile cataracts can be effectively cured with eye drops containing L-CARNosine.
Even the heart is kept healthy by this compound as well. The heart tissue muscle is strengthened by this compound and enzymes that enable the heart muscles to contract are also activated by it.
How to Increase the Level of L-CARNosine in the Body?
Those who want to increase the amount of this beneficial dipeptide in their body should eat a diet that essentially includes fish, meat and poultry. Dietary supplements can also supply the body with this compound. L-CARNosineis contained in certain multivitamin supplements, which contain various other amino acids, minerals, vitamins and other special nutrients. Thus, the overall positive effective of this compound in the body can be further enhanced by taking such supplements.
As long as the supplement being used contains nothing but natural ingredients, supplementing this compound in the body can help an individual avail many health benefits. L-CARNosine is, therefore, an important dipeptide and those who are growing old should consider supplementing it through diet or supplements.
How Does N-Acetyl L-Carnitine Help Energy Levels?
August 03, 2011 11:47 AM
N-Acetyl L-CARNitine And Cellular Health
N-Acetyl L-CARNitine refers to the ester form of the organic compound carnitine. It has been linked to many different health benefits largely owing to the fact that it is quite ubiquitous at the cellular level. It plays an important role in keeping cells in prime working condition as derivatives of this compound protect cells from oxidative stress as well as contribute to reactions responsible for energy production.
Increases Cellular Energy
The biochemical energy that powers cellular activities comes in the form of adenosine triphosphate. All types of tissues in the human body are capable of manufacturing this chemical compound, the reason why it is often called the molecular unit of currency. The human diet provides the biological precursors of cellular energy, but adenosine triphosphate is obtained from the sugar glucose more often than not.
Cells make use of N-acetyl L-CARNitine in the synthesis of adenosine triphosphate. Research has shown that the presence of acetylated carnitine appears to modulate the metabolic processes leading to the manufacture of cellular energy. In recent years, endurance athletes and body builders have relied on supplements that contain this compound to boost their energy levels. Human trials support its safety.
Aids Healthy Metabolism
Glucose is the principal precursor of chemical energy in the form of adenosine triphosphate. Complex carbohydrates are digested to simple sugars such as glucose, which enters the circulation. Insulin is a hormone that induces the uptake of glucose by cells, which convert glucose to usable energy. Studies have observed that N-acetyl L-CARNitine improves the activity of insulin and consumption of glucose.
It is a well established fact that carnitine is involved in the breakdown of fats, waxes, and sterols, and their consequent utilization in the production of cellular energy. For this reason, N-acetyl L-CARNitine is marketed as a nutritional supplement that promotes fat loss and aids weight loss. Human trials have noted that regular intake upregulates the conversion of fats and other lipids to adenosine triphosphate.
Prevents Oxidative Stress
Lysine and methionine are amino acids that act as immediate precursors of carnitine, which the body synthesizes on a regular basis to support a number of physiological functions. In particular, carnitine plays a major role in supplying cells with a steady supply of chemical energy during intense physical exertion. At the same time, they protect the cells from the harmful effects of reactive oxygen species.
N-acetyl L-CARNitine is a very good source of carnitine as it is widely believed to be more bioavailable than L-CARNitine. It adds to the number of carnitine in cells, boosts energy levels, and combats free radicals and other reactive oxygen species. Free radicals are natural by-products of energy production, and thus carnitine produces a twofold effect. It promotes cellular longevity and raises chemical energy.
How does Acetyl-L-Carnitine Help With Heart Health?
February 21, 2011 02:37 PM
Acetyl L Carnitine And Heart Health
Acetyl-L-CARNitine is a form of the chemical compound carnitine, which is active in the human body as the amino acid L-CARNitine. It is an organic substance that is naturally occurring in mammals and many other animals, and it is released from the liver and kidneys to every tissue in the body. While our body is capable of manufacturing this amino acid, there are factors involved in its depleting levels at certain times, and thus it is made available as a nutritional supplement. Today it is primarily used as a treatment for heart diseases and other cardiovascular problems.
Helps Break Down Fats
One of the many factors that influence heart tissues is high levels of free fatty acids in the blood. Popular health magazines and the mainstream press have labeled transports of fat-soluble bioactive compounds in the water-based bloodstream as bad cholesterol, but free fatty acids are also to blame for the buildup of fatty debris in the blood vessel linings, resulting in the thickening of walls characteristic of many cases of heart diseases.
The body has a mechanism to utilize these fats more effectively in the presence of Acetyl-L-CARNitine, which is quite active as soon as it enters the cells of any tissue, notably muscle and skeletal tissues. Free fatty acids are formed as a by-product of triglycerides that remained in the blood, but once they pass the cell membranes, they can be a source of energy far more powerful than that produced from glucose. Acetyl-L-CARNitine makes it possible for these fatty molecules to be converted into energy.
Maintains Heart Wellness
Every cell has its own form of storage fuel, and glucose and its metabolites are probably the best known. However, tissues of the heart and the muscles prefer fatty acids. As you might have surmised, tissues found in the heart and those that build the form of our physique, classified as cardiac and skeletal respectively, needs more energy than other tissues of our body. The skeletal muscles are directly involved in daily physical exertion whereas the heart is, of course, in constant movement.
Fatty acids yield adenosine triphosphate, or ATP, the form of energy at the cellular level, which is in general more than two times the energy produced from either carbohydrates or proteins. This is one of the reasons why fatty acids can keep up with the hard work associated with cardiac and skeletal muscle tissues. The absence of energy required for the healthy functioning of the heart leads to cell death and affects the heart’s ability to pump blood as described in cases of heart failure.
Promotes High Bioavailability
Acetyl-L-CARNitine has been touted to be more absorbable and ultimately incorporated in body tissues more effectively than other forms of carnitine. It is a known fact that acetylating organic molecules increases the effectiveness of administered doses, and this remains true with Acetyl-L-CARNitine, the reason why it is widely applied in serious medical conditions concerning the heart.
If you have heart problems, give Acetyl-L-CARNitine a try risk free.
Natural Vitamins for the Heart
July 06, 2010 02:44 PM
It has been consistently revealed by epidemiological research that individuals with a high dietary intake of antioxidant vitamins have a risk that is lower-than-average of cardiovascular disease. This evidence seems to be especially consistent for vitamin E. Additionally, many clinical studies show that magnesium supplementation is of significant benefit in the treatment of cardiac arrhythmias and in reversing the depletion of potassium that comes along with a magnesium deficit. Many cardiovascular events like angina pectoris, congestive heart failure, and cardiomyopathy are related directly to low magnesium status. Coenzyme Q10 is an essential component in cellular energy production. This nutrient is also prevalent in the heart muscle. When tissue levels of CoQ10 are low, there is an association with several cardiovascular complications. Among these are angina, congestive heart failure, cardiomyopathy, hypertension, and mitral valve prolapse. Research has found that the trio of coenzyme Q10, vitamin E, and magnesium plays a crucial role in the maintenance of cardiac health and the prevention of disease states.
The cardio-protective effect of vitamin E seems to come from its ability to bind to LDL cholesterol, which protects it from free-radical induce oxidative damage along with the consequent buildup of atherogenic plaque. Low levels of vitamin E in the blood are a predictive factor of heart health almost 70% of the time.
Studies on the general population have suggested that there is a link between the intake of calcium and blood pressure. Although results of the studies have not been consistent, there are several studies showing that calcium supplementation can lower blood pressure in those individuals who experience hypertension. Overall, those intakes of calcium that are sub-optimal contribute directly to hypertension. It seems that dietary calcium reduces blood pressure by normalizing intracellular calcium levels.
Supplementation with magnesium is of benefit for the treatment of cardiac arrhythmias and the prevention of potassium depletion. Both magnesium and potassium play an important role in the functioning of the heart. Several studies have found that there is improvement in heart function in those patients that have cardiomyopathies when they supplement with magnesium. Since magnesium acts in so many ways to enhance cardiac function and optimize cellular metabolism, magnesium is widely recognized as a critical nutrient for general cardiac support.
Several double-blind studies have taken place in those patients that experience various cardiomyopathies in order to show the benefits of CoQ10 supplementation. One study reported an 89% improvement rate in 80 cardiomyopathy patients who were treated with CoQ10. The coenzyme also appears to moderate blood pressure through the usual mechanism, as it lowers cholesterol levels and also stabilizes the vascular system with its antioxidant properties. Because of this, it is able to reduce vascular resistance. Several studies on CoQ10 supplementation have confirmed that this nutrient posses the ability lower both systolic and diastolic pressures by up to ten percent.
There are other nutrients that play important roles in optimizing cardiovascular health and reducing hypertension. Among these nutrients are gamma tocopherol, calcium, magnesium, L-CARNitine, acetyl-L-CARNitine, procyanidolic oligomers, phenolic compounds, and lycopene. As you can see there are many natural supplements that can help the cardiovascular system. Remember to always consult your doctor before adding supplements to your diet while on prescription drugs. Look to your local or internet health food store for quality vitamins, herbs, and specialty formulas to boost your health and wellness.
May 07, 2009 05:45 PM
L-CARNitine is amino acid essential for the metabolism of fats into a form of energy necessary for extended aerobic activity. Originally discovered in Russia, and Germany a year later, the structural formulation of carnitine, as it is correctly known, was determined in 1927, although it is physiological and biochemical activity was not understood until the 1960s.
The amino acid is biosynthesized in the liver and kidneys from lysine and methionine. The vitamins niacin, B6, C and iron are essential for this reaction to take place. However, the supply of L-CARNitine has to be supplemented by the diet, good sources being dairy products, red meat, nuts and seeds, pulses and fruits such as apricots, bananas and avocado. Most of the L-CARNitine supply of the body is stored within the muscle tissue. However, it is not unusual for conditions to arise making it difficult for the body to obtain all the carnitine required.
L-CARNitine enables fatty acids to be transported into the mitochondria, where cell metabolism occurs. The biochemistry is discussed below, although in simple terms the amino acid allows body fats, in the form of triglycerides, to be made more readily available for the generation of energy required for extended exertion. In this way, body fats can be used for energy and the supplies of glycogen stored by the liver can be retained for emergency use.
By providing the energy for endurance and stamina in this way, carnitine makes use of an otherwise unavailable energy source, and has the added benefit of reducing body fat stores and reducing strain on the heart.
Although there is generally a plentiful supply of L-CARNitine available in a healthy diet, supplementation can ensure that a deficiency does not occur. Supplements are available in the form of L-CARNitine or its acetylated derivative, acetyl L-CARNitine.
In order for fatty acids to be used in the production of energy, their long-chain acetyl groups have to get inside the mitochondria where they are oxidized to the acetate to be used for the production of energy via the Citric Acid or Krebs cycle.
In order for the biochemistry to take place, fatty acids must be rendered suitable for binding to the carnitine molecule. The chemical grouping with a good affinity for L-CARNitine is the acetyl or acetyl group, available in the molecule acetyl coenzyme A (CoA). The free fatty acid, therefore, is attached to coenzyme-A by means of a thioester bond, catalyzed by means of the enzyme fatty acetyl-CoA synthetase. The reaction is then completed by means of in organic pyrophosphatase.
In this way, the fatty acid in the form of an acetyL-CARNitine derivative can be transported through the mitochondrial wall. This transportation takes place by means of several steps. These are:
1. As explained, the acetyl-CoA is attached to L-CARNitine by means of the enzyme carnitine acetyltransferase I. This enzyme is conveniently located on the outer mitochondrial membrane.
2. The enzyme carnitine-acetylcarnitine translocase helps the acetyL-CARNitine through the membrane.
3. Another enzyme, carnitine acetyltransferase II, located on the inner mitochondrial membrane, converts the acetyL-CARNitine to acetyl-CoA, liberating the carnitine which returns to the muscle mass.
L-CARNitine is the only known substance that allows fatty acids to cross the mitochondrial membrane, and therefore deficiencies must be avoided.
Another way in which carnitine is used in energy production is in the Krebs cycle itself. Part of this cycle involves the conversion of guanine diphosphate to the higher energy form guanine triphosphate. In this way energy can be stored in much the same way as it is in the conversion of ADP to ATP. Succinyl CoA is involved in this conversion, and one of the by-products of it is a corresponding succinate, that is then converted to a fumarate by the action of L-CARNitine fumarate. Carnitine, therefore, has two parts to play in the production of long-term energy from the fatty acids contained in body fats.
Since the fatty acid triglycerides contained in body fats are a major source of energy in the heart and skeletal muscles, it is easy to understand how L-CARNitine is believed to lead to the increased energy levels required for stamina and staying power. A major reason for its effect on longer-term or extended energy requirements is that in enabling stored body fats to be used for immediate and longer-term energy requirements, L-CARNitine allows emergency glycogen stores to be retained for use once immediate fatty acid supplies or those of carnitine have been depleted, and so allows the energy supply to be extended even farther. Research has also suggested that the amino acid can possibly be used to treat liver and kidney disease, diabetes and chronic fatigue syndrome.
As with many supplements, the question is often asked how does L-CARNitine work in practice as opposed to the claims made for it by the supplement providers? Recent research indicates mixed results, but sufficient to justify its use. It is generally accepted that a supplement is necessary when there is a deficiency, but once that deficiency has been corrected further intake is unnecessary. However, it is also believed that during long and extended periods of exercise a carnitine deficiency does occur as L-CARNitine is used up, and the supplement is necessary to ensure sufficient energy supply throughout the period of exercise.
There has also been a case reported in the Journal of Clinical Neurology (Negoro, Tsuda, Kato & Morimatsu, 1995) where a deficiency, caused by anorexia nervosa damaging the liver to the extent that it was unable to synthesize L-CARNitine, was remedied by means of an oral supplement. Studies on endurance athletes have been mixed, ranging from no effect to L-CARNitine being found to promote weight loss.
Carnitine has no unknown harmful side effects, and has been studied for medical applications other than as an energy supplement. For example it possesses extensive antioxidant properties, and can be used as a supplement against oxidative stress and the prevention of the lipid peroxidation that is a precursor to atherosclerosis.
Its use in osteoporosis and reducing bone mass is also being studied. The concentration of L-CARNitine diminishes with age, and affects fatty acid metabolism in a number of tissues. Bones are particularly affected since they require continuous reconstruction. Without detailing the biochemistry involved in this, administration of carnitine helps to reduce the speed by which this occurs. Trials are so far been carried out only on animals.
In studies on both healthy volunteers and patients with type II diabetes, L-CARNitine was found to improve storage of glucose in both groups, although its oxidation increased only in the group with diabetes. Other studies carried out include improving the function of neurotransmitters in the brains of elderly patients and in the treatment of Alzheimer's and Parkinson's disease, and other neurological disorders.
In conclusion then, although the jury is out on the use of L-CARNitine is an energy-giving or weight-loss supplement, it appears to be effective where the body's stores of carnitine could be depleted such as with long-term exercise, natural deficiencies or deficiencies caused through age. It is also under study in the treatment of various medical conditions. On balance, it would appear that the prospective benefits of L-CARNitine render it worthy of use.
NOW Foods is the Leading Brand for Amino Acids in Health Food Stores
April 29, 2009 04:16 PM
-Michael Lelah, Ph.D. / Technical Director
It was recently announced that NOW Foods is now the leading brand for the amino acid segment in Health Food Stores. We sell over 100 different formulas of single and multiple amino acids in powder, capsule, tablet, and liquid forms. We cover the alphabet from L-Arginine to L-Tyrosine, with high potency products such as Acetyl L-CARNitine 750 mg, 1,000 mg L-CARNitine Tartrate, and our new 1000 mg L-Tryptophan Tabs coming in June. Most amino acids come in two optical forms – the L-form and the D-form. The L-form is the only true natural form, while the more common D- and DL-forms are synthetic. At NOW Foods, we only carry the natural L-form. This is the safest form, naturally found in foods and in the human body. Taurine and Glycine have no optical rotation, and therefore occur in only one natural form with no L- or D- designation.
Our L-amino acids are of the highest quality available, and our ingredient powders conform to USP standards. The USP standards cover identity, purity and potency testing. This means that each lot of amino acid ingredient is tested to ensure that (a) it really is the amino acid we say it is, and not something else, (b) it’s pure to the highest USP standards, and (c) it has the full potency that you require. At NOW Foods, we take our amino acids seriously, and we even go beyond the USP level of testing when we believe it is necessary. For example, every lot of our L-Tryptophan is tested to ensure that it is free of Peak E. This is the impurity which is believed to have been responsible for serious adverse events twenty years ago. We rigorously enforce this standard, and this goes beyond USP requirements. We have rejected a number of lots of L-Tryptophan because of the presence of Peak E. We will not sell you these rejected materials, and we hope that others do not as well. We can’t control what others do, but we can control what we do and we assure you of L-Tryptophan tested to be free of Peak E.
Our state-of-the-art analytical labs allow us to perform our own testing on our amino acids to doubly ensure their quality. We have 9 HPLCs that we use every day to test and retest our aminos to confirm their potency, purity and identity. We have very strong analytical, professional, and technical staff members who have many years of experience in testing amino acids. So much so that we are involved in developing industry validated methods for L-CARNitine and L-Arginine. NOW scientists are setting the standards for amino acid testing.
Most amino acids are quite stable and they can be packaged in standard containers. These amino acids will maintain their shelf life through their Best By date, and we test to make sure they do. SAMe however, is a uniquely unstable amino acid compound. Because of this, we provide triple protection – glass bottles, moisture control and oxygen control. SAMe is distinctly susceptible to oxygen degradation. We are the only major brand to offer our SAMe packaged with Ageless® oxygen absorbing packets, which remove integrity-challenging oxygen from every bottle to reduce degradation. We go that one step further to protect our products! Finally, we’re the leading amino acid brand because our products work. As an example, in a published study2, our SAMe was directly compared against the leading drug – Celebrex®.
NOW Foods brand SAMe performance was the same as the drug supporting joint health, but without the pharmaceutical side effects. All in all, we are not the leading brand in this category just because of our great prices. We have significant science and quality behind all of our products, not just amino acids, and we hope that you consider our rigorous efforts in quality assurance, safety and efficacy when making a purchase.
1. SPINScan Natural Channel, 52 weeks ending 02.21.09. 2. Najim, W.I., et al, SAMe versus celecoxib…, BMC Musculoskeletal Disorders 2004, 5:6.
April 15, 2009 01:20 PM
Thrombophlebitis is when inflammation occurs in the veins due to the formation of a blood clot in that vein. This problem usually occurs in the extremities, especially the legs. Thrombophlebitis can be considered superficial if it affects the subsutaneous vein, which is one of the veins near the skin’s surface.
In superficial thrombophlebitis, the affected vein can be felt and may be seen as a reddish line under the skin. Additionally, swelling, pain, and tenderness to touch can occur. If widespread vein involvement is included, the lymphatic vessels may become inflamed. Superficial thrombophlebitis is a relatively common disorder that can be brought about by trauma infection, standing for long periods of time, lack of exercise, and intravenous drug use. The risk of superficial thrombophlebitis can be increased by pregnancy, varicose veins, obesity, and smoking. Thrombophlebitis can also be associated with environmental sensitivities to allergies. This condition is usually diagnosed according to physical findings and a medical history that indicates an increased risk.
Deep thrombophlebitis (DVT) affects the intramuscular veins farther below the skin’s surface. DVT is a much more serious condition than superficial thrombophlebitis because the veins affected are larger and located deep within the musculature of the leg. These veins are responsible for the transport of 90 percent of the blood that flows back to the heart from the legs. Symptoms of DVT may include pain, warmth, swelling, and bluish discoloration of the skin of the affected limb. These symptoms are often accompanied by fever and chills. The pain is typically felt as a deep soreness that is worse when standing or walking and gets better with rest, especially with elevation of the leg. The veins directly under the skin may become dilated and more visible. Inflammation situated in a vein in the pelvis is referred to as pelvic vein thrombophlebitis.
The reason or reasons for the formation of the clots in the veins are often unknown. However, in most cases, clots are probably the result of a minor injury to the inside lining of a blood vessel. If the vessel lining receives a microscopic tear, clotting is initiated. Platelets clump together to protect the injured area, and a series of biochemical events is initiated that results in the transformation of fibrinogen, a circulating blood protein, into strands of insoluble fibrin, which are deposited to form a net that traps blood cells, plasma, and yet more platelets. This results in a blood clot. Other possible causes of the formation of DVT include abnormal clotting tendencies; poor circulation; certain types of cancer; and Behcet’s syndrome, which is a condition that affects small blood vessels that predispose an individual to the formation of clots. The following factors increase the risk of DVT: recent childbirth, surgery, trauma, the use of birth control pills; and prolonged bed rest.
The following nutrients are recommended for the prevention and treatment of thrombophlebitis: acetyl-L-CARNitine, coenzyme Q10, flaxseed oil, garlic, l-cysteine, lecithin granules, l-histidine, magnesium, MSM, Pycnogenol, vitamin C with bioflavonoids, vitamin E, zinc, and vitamin B complex. Additionally, the following herbs may be beneficial: alfalfa, pau d’arco, red raspberry, rosemary, yarrow, butcher’s broom, cayenne, ginger, plantain, witch hazel, skullcap, valerian root, ginkgo biloba, goldenseal, hawthorn, and olive leaf extract.
Natural vitamins are a great way to help prevent conditions such as these. If you suspect that you have thrombophlebitis, consult your doctor before trying to take the problem into your own hands. Natural vitamins such as the ones listed above can be found at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Natural vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
Vitamins and Herbs
April 03, 2009 02:52 PM
The whole human body is made up of cells that contain their own genetic material. In a healthy body, these cells divide at a controlled rate, growing and repairing damaged tissues and replacing dying cells. This predetermined rate of cell division is what keeps our bodies healthy. If cells keep multiplying when new ones are not necessary, a mass of tissue, often known as a tumor, is formed. This tumor can be either benign or malignant.
Benign tumors are not cancerous and can occur anywhere in the body. Benign tumors do not cause a threat to health, do not metastasize, and do not grow back if removed. Malignant tumors are cancerous and are usually serious. Often times, they can be life-threatening. Malignant tumors grow uncontrollably, interfere with normal metabolic and organ functioning, and have the ability to metastasize and invade other tissues. If a portion of a cell’s DNA is damaged, the cell can become abnormal. When an abnormal cell divides, it forms new cells that are a photocopy of the damaged genetic material. This ongoing process occurs constantly within our bodies. The majority of the time our bodies have the ability to destroy these abnormal cells and maintain a sort of cellular equilibrium. If a crucial part of the DNA is destroyed and the abnormal cells cannot be controlled any longer, cancer forms. All cancer cells have two things in common: growing uncontrollably and having the ability to metastasize. The immune system does not recognize cancer cells as dangerous or foreign.
Although the exact cause for the cell damage that initiates the cancer process is unknown (theoretically free radical damage causes DNA damage), the chain of events that leads to cancer is very complex, and each individual body reacts differently. It is a combination of genetic, behavioral, environmental, and lifestyle factors that are thought to be involved in turning normal cells into abnormal cells, and abnormal cells into cancer.
There are also factors that are believed to slow the process, while other factors can speed up the process. Possible contributors to the development and growth of cancer can be divided into three categories: external, internal, and lifestyle. External factors include unhealthy workplace environments and exposure to air and water pollution, chemicals, pesticides, and herbicides. Included in the internal factors include both genetics and infections. Lifestyle factors are those we personally can most readily control, such as diet, smoking, drinking, and sun exposure. External and lifestyle factors account for 80 percent of cancer deaths in the United States.
Just as each of us looks different, each of our bodies has its own unique composition. Some of us may react adversely to what some of us react well to. This is why some treatments prove to be successful for some, but not for others. This is why dietary wellness and prevention is so important. If we can keep our bodies healthy and avoid known cancer-causing agents, we have a good defense against cancer in the first place.
The following nutrients and supplements are designed for persons who have been diagnosed with cancer, as well as for those who wish to enhance their chances of avoiding the disease: coenzyme Q10, colostrum, DMG, garlic, IP6, melatonin, MSM, proteolytic enzymes, selenium, 7-keto DHEA, shark cartilage, SOD, vitamin A, shiitake extract, acidophilus, chromium picolinate, flaxseed oil, grape seed extract, kelp, L-CARNitine, multienzyme complex, a multi-mineral complex, multivitamin complex, NAC, raw glandular complex, taurine, and vitamin B complex. Additionally, the following herbs may be beneficial: astragalus, birch, burdock root, cat’s claw, chaparral, chuchuhuasi, cranberry, dandelion, Echinacea, fennel, green tea, licorice root, macela, milk thistle, parsley, pau d’arco, red clover, suma, cardamom, cayenne, ginger, rosemary, sage, thyme, turmeric, ragwort, wood sage, curcumin, essiac, noni, olive leaf extract, rosemary, and boswellia.
All of the above listed herbs and vitamins can help restore the body to good nutrition and help boost the immune system so the body can find and fight back against cancer. Natural vitamins and herbs are available at your local or internet health food store. When purchasing supplements, look for name brand vitamins like Solaray and Source Naturals to ensure you receive quality and you get what you pay for.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Natural vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
March 23, 2009 01:56 PM
Our memory is as natural to us as breathing. An ability we all have, but don’t often think of, it doesn’t seem to cross our mind until we perceive that we are losing the ability. Memory lapses are an annoyance in themselves, but the anxiety that often comes along with them seems to be even worse. We often wonder if our memory problems are a symptom of some other problem like midlife depression, arteriosclerosis, or even Alzheimer’s disease. Although Alzheimer’s disease is a fairly common disorder among older people, one must realize that most memory lapses have nothing to do with Alzheimer’s disease.
Generally, it is believed that increasing age brings about an increased likelihood of developing memory loss. The mildest form of this illness is called age-associated memory impairment. This is characterized by one’s perception of his or her own memory loss and it is estimated that it is experienced by 40 percent of Americans over the age of sixty-five. Not all memory loss is attributable to aging, as occasional memory lapses are a natural normal part of life at almost any age, and are not likely to precede serious memory loss. With a proper diet, nutrition, and memory use, the memory should remain sharp and active well into one’s nineties or beyond.
One big reason why people suffer from memory loss is an insufficient supply of necessary nutrients to the brain. The life of the body is in the blood, as it literally feeds and nourishes every cell within our bodies. Only certain substances are allowed to pass from the bloodstream into the brain, thanks to the protective envelope that is known as the blood-brain barrier. If the blood is thick with cholesterol and triglycerides, the amount of nutrient-rich blood that can pass through the blood-brain barrier decreases. This can result in the brain becoming malnourished over time.
The functioning of the brain also depends upon substances that are referred to as neurotransmitters, which are brain chemicals that act as electrical switches in the brain and are responsible for all the functions of the body. If the brain does not have an adequate supply of neurotransmitters, or the nutrients to make them, it starts to develop something similar to a power failure or a short circuit. If you are trying to recall as specific fact or piece of information and your mind goes blank, it is likely that the above “short circuit” has occurred.
There are many other factors that are involved in the deterioration of the memory. One of the most important is exposure to free radicals, which can cause huge amounts of damage if the memory is unchecked. Alcoholics and drug addicts often suffer a great deal of memory loss, with alcoholics being notorious for huge memory gaps that occur even though they are conscious. Allergies, candidiasis, stress, thyroid disorders, and poor circulation to the brain can also contribute to memory loss, while hypoglycemia can play a role in memory loss as well, as the brain requires that the level of glucose in the blood fall within a specific narrow range. Wide swings in blood sugar levels affect brain function and memory.
The following nutrients are beneficial in dealing with and preventing memory loss: acetylcholine, boron, DMAE, garlic, huperzine A, lecithin granules, manganese, multivitamin and mineral complex, omega-3 fatty acid complex, phosphatidyl choline, phosphatidyl serine, SOD, vitamin A, vitamin B complex, vitamin B3, vitamin C, vitamin E, zinc, acetyl-L-CARNitine, l-glutamine, l-tyrosine, coenzyme Q10, DHEA, DMG, melatonin, NADH, pregnenolone, RNA and DNA, Brahmi, ginkgo biloba, anise, blue cohosh, ginseng, gotu kola, and rosemary.
All of the above mentioned as well as formulas tailored to help improve memory can be found in capsule, table, or power forms. Remember, only look to name brands such as Solaray, Source Naturals and Natures Plus for quality products. Memory vitamins and herbs can be found at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
EFA's - Essential Fatty Acids
September 15, 2008 09:42 AM
Many recent studies have found that EFAs may be extremely helpful for many chronic, stubborn conditions. Their continuously growing range of applications includes overcoming diseases such as alcoholism, breast cancer, and cardiovascular disease; strengthening the immune system; helping eliminate yeast infection; reducing symptoms of premenstrual syndrome; minimizing inflammation of rheumatoid arthritis; and assisting in the proper management of weight.
Alcohol dependence is an extremely serious condition that often results in decreased life expectancy, suicide, degeneration of the brain and liver, osteoporosis, and many other conditions. For each person, the rate at which alcohol is metabolized in the body is different, as a lot of it has to do with the person's nutritional status, the concentration and activity of liver enzymes, and the rate at which alcohol is consumed.
Alcoholics tend not to eat because the calories from alcohol, although nutrient-poor, diminish the appetite, causing many alcoholics to become extremely malnourished. An overall nutritional program should be employed to those people who are dependant on alcohol, which should include vitamins A, C, and B, complex, along with zinc, magnesium, selenium, amino acids, milk thistle, acidophilus, antioxidants, L-CARNitine, and essential fatty acids. EFAs, especially those that are high in GLA, keep blood lipid levels from going out of control.
The body's immune system has a vital role in protecting us against cancer, as it recognizes and annihilates any abnormal cells before they have the chance to multiply and do damage. When the immune system is overwhelmed or not functioning properly, abnormal cells will reproduce without having anything to stop them. Because of the rapidly growing tumors which have a huge appetite for nutrition to keep them going, cancer patients often become malnourished and lose weight. A diet that is rich in cruciferous vegetables, fiber, antioxidants, vitamins A, C, and E, minerals, and essential fatty acids can help prevent breast cancer. Research shows that EFAs, especially GLA, have anti-tumor properties.
All of the cells in the body have a dependence on nutrients that are transported through the circulatory network. When blood vessels become clogged with fats and cholesterol, nutrition distribution is hindered and blood flow can be stopped in some areas, causing the heart to die. Exercise is a good for increasing circulation and keeping the blood from getting stuck. A diet that is high fruits, vegetables, natural fiber, and low in saturated fats, meats, and homogenized dairy products is also a good idea. Additionally, antioxidants, hawthorn berry, ginkgo biloba, vitamin E, Co Q-10, L-CARNitine, calcium, magnesium, potassium, and EFAs will also be of benefit to the cardiovascular system.
Essential fatty acids have been shown to stop the growth of yeast organisms in the body. They do so by helping the oxygen to flow to cells. Since yeast is anaerobic, it cannot thrive in the presence of oxygen. Yeast overgrowth can cause a variety of symptoms that are often diagnosed as another condition, ranging from joint swelling to memory loss.
PMS is a collection of symptoms that occurs one to two weeks before menstruation, affects about one-third of women who are younger than forty. It is caused by hormone imbalances, which result in anxiety, irritability, and mental sluggishness. Research has found that women with PMS usually eat more refined carbohydrates, dairy products, and sodium, and less iron and other minerals than those women who do not experience this condition. Vitamin B complex, beta carotene, vitamin E, magnesium, milk thistle, acidophilus, and essential fatty acids are very helpful for PMS. Essential fatty acids, especially GLA, are helpful in balancing the body's hormone levels.
Reducing symptoms of disease like arthritis or PMS is important to all those who suffer from them. EFA's can help reduce the symptoms of these diseases. American diets are low in EFA's and one should consume them either in the foods they eat or supplement form to help the body strengthen its self and fight off disease.
August 12, 2008 01:37 PM
Vitamin C is the most widely taken nutritional supplement on the market and is available in a variety of forms, including tablets, drink mixes, crystals in capsules or bulk powdered crystals. Vitamin C is present in mother's milk and, in lower amounts, in raw cow's milk, with pasteurized milk containing only trace amounts. This vitamin is most present in the liver and least present in the muscle but needed through out the body.
Vitamin C is required for the synthesis of collagen, an important structural component of blood vessels, tendons, ligaments, skin, and bone. Vitamin C can regenerate other antioxidants such as vitamin E; in the body vitamin E can regenerate C as well. This vitamin is required for the growth and repair of tissues in all parts of your body. Relatively large doses of vitamin C may cause indigestion, particularly when taken on an empty stomach.
It has been shown that smokers who have diets poor in vitamin C are at a higher risk of lung-borne diseases than those smokers who have higher concentrations of Vitamin C in the blood. Biological tissues that accumulate over 100 times the level in blood plasma of vitamin C are the adrenal glands, pituitary, thymus, corpus luteum, and retina.
Studies suggest the presence of large quantities of sugar either in the intestines or in the blood can slow absorption of this vitamin. Several studies have demonstrated a blood pressure lowering effect of vitamin C supplementation. Also, when consumed in high doses it appears to interfere with the blood thinning effects of warfarin by lowering prothrombin time, as noted in case reports in the 1970s so consult your doctor if on medications..
In one Study, researchers instructed patients with documented coronary artery disease to take a single oral dose of either 2 g vitamin C or a placebo. Results, the researchers discovered that high doses of vitamin C can help prevent blood platelet sticking and fight cholesterol oxidation. Also, researchers discovered this vitamin can reduce the formation of potentially carcinogenic nitrogen-containing compounds in the stomach, offering protection from stomach cancer, researchers have reported.
French and German researchers found that vitamin C appeared to keep cells in the blood vessel wall from dying. The researchers, who studied immune indicators, such as serum immunoglobulin and neutrophil phagocytosis (how well your white blood cells can engulf and digest foreign bodies), concluded that vitamin C exerts a remarkable immuno-modulating action, in other words, improved immune function in all those who consumed vitamin C on a regular basis.
What are deficiency symptoms for vitamin C?
Scurvy is a disease resulting from lack of vitamin C, since without this vitamin, the synthesized collagen is too unstable to perform its function. Scurvy was common among those with poor access to fresh fruit and vegetables, such as remote, isolated sailors and soldiers. The amount of vitamin C required to prevent “chronic disease” appears to be more than that required for prevention of scurvy which is 30 – 60 milligrams per day. Based on scientific research, vitamin C also appears to improve oral absorption of iron, which is good news for those that are anemic.
Half of us in the United States will die from heart disease. The foundation of heart disease is atherosclerosis, the narrowing of our arteries with plaque. Treatment with vitamin C has consistently resulted in improved dilation of blood vessels in individuals with atherosclerosis as well as those with angina pectoris, congestive heart failure, high cholesterol, and high blood pressure. Researchers believe this protection from cell death could explain previous study findings which suggest that vitamin C benefits blood vessel function in people with congestive heart failure.
Vitamin C supplements are also generally regarded as safe in most individuals in recommended amounts, although there are rarely reported side effects including nausea, vomiting, heartburn, abdominal cramps, and headache. In addition, this vitamin is required for the synthesis of L-CARNitine, a small amino acid that is essential for the transport of fat to cellular organelles called mitochondria, for conversion to energy. If you have chronic fatigue syndrome, vitamin C may help by boosting energy production through the mitochondria.
Therefore, as in many studies of vitamin C intake and cardiovascular disease risk, it is difficult to separate the effects of vitamin C on stroke risk from the effects of other components such as diet and the consumption of fruits and vegetables. As with all dietitians an emphasis on the benefits of a diet rich in fruits and vegetables is important to maintain a healthy cardiovascular system. If one can not consume fruits and vegetables on a daily basis then supplementation of vitamin C is need in either capsule of tablet to fight the risk of disease.
L-Carnitine For Health And Wellness
April 16, 2008 03:25 PM
Research continues to mount evidence that L-CARNitine can help boost energy and quality of life. Carnitine comes from the Latin word for flesh: caro or carnis. L-CARNitine was discovered and isolated from meat in the early 1900s. At that time, scientists thought that L-CARNitine played a role in muscle function; this was many years before technology would advance so that this theory could be proved. Today, we know that this amino acid is found mostly in tissue of the body that requires lots of energy such as the heart, skeletal muscles, and liver.
L-CARNitine is considered a non-essential amino acid since the body manufactures it from l-methionine and l-lysine. Depending on one’s diet, the body manufactures most of, not all, the L-CARNitine it needs every day. There are circumstances where a rare genetic disease can cause the body to not manufacture its own L-CARNitine resulting in a deficiency which can cause secondary diseases such as cirrhosis of the liver, chronic renal failure, diabetes, heart failure or Alzheimer’s disease. Some medications can cause a deficiency as well, check with your doctor about prescriptions.
The primary energy source for the body is long-chain fatty acids. L-CARNitine plays an essential role in energy production process. This amino acid transports long-chain fatty acids into the mitochondria, where it is used to produce energy for each cell in the body. L-CARNitine then removes the “acyl” group by products out of the mitochondria as they accumulate. Both the transporting in and out of the cells mitochondria is vital for continued muscle function to occur.
Researchers suggest that the limiting factor in high intensity exercise is from the availability of L-CARNitine in the muscle tissue. Studies conducted with this amino acid suggest that athletes experience improved performance when supplementing with L-CARNitine by reducing post exercise lactate acid levels and improving recovery from exercise stress.
Some research suggests that L-CARNitine can help chronic fatigue individuals by shuttling long-chain fatty acids into the mitochondria where the body manufactures energy. The bulk of this research was done on chronic fatigue patients who consumed 2 grams per day of L-CARNitine. Additional research was performed on individuals over 100 years of age and the results were these individuals experiences increase physical endurance and improved cognitive activity.
L-CARNitine can help cardiovascular conditions including angina, congestive heart failure, and peripheral artery disease. Recent studies showed male fertility improvement when L-CARNitine was consumed on a regular basis. Men participating had better sperm motility which increases the changes of one reaching an egg and improving the odds of fertilization.
Research also demonstrated that 1 gram of this amino acid daily over three months can help one reduce weight by improving fat metabolism. This holds consistent with the findings that L-CARNitine transports long-chain fatty acids (fat) into cellular mitochondria so it can be burned as energy. With a good diet and exercise plan, reports suggest that even more weight loss can be achieved.
Safety is of particular concern when adding extra supplements to one’s diet such as L-CARNitine. Good news, L-CARNitine is very safe at 1 – 3 grams each day, even higher doses are safe with no side effects. With the mounting evidence on the benefits of L-CARNitine consumption, what is stopping you from adding L-CARNitine today to your supplement diet to improve health and wellness?
Alpha Lipoic Acid is a Powerful Antioxidant
February 15, 2008 02:55 PM
The discovery of alpha lipoic acid at the University Of Texas Chemistry Department in 1951 was not heralded with trumpets of joy at the revelation of such a powerful antioxidant, but was instead largely ignored. This is largely due to the biochemistry involved not being fully understood at that time, but by the 1980s it was a commonly used supplement, recommended for several medical conditions.
Chemically, the substance is a 5-membered cyclic disulphide with a carboxylic acid grouping. Biochemically, it’s extremely powerful antioxidant properties are largely due to the fact that it one of those rare active molecules that are soluble in both water and fats, and in fact is the only such antioxidant currently know. One of the properties that this ability enables it to possess is to cross the blood-brain barrier, and apply antioxidant propertied to the brain.
Antioxidants are essential to human life in that they destroy free radicals. These are compounds with free unpaired electrons that destroy human body cells in their hunt for electrons to pair with. Electrons come in pairs in organic animal tissue, just as they do in organic compounds. However, under certain circumstances this pairing can become destroyed, leaving a molecule with one of its electrons without a partner.
The factors that lead to this situation are many and varied, and our own biochemistry can produce free radicals during the normal chemical processes of life. However, pollution can also lead to the oxidation processes that create free radicals, common such pollutants being cigarette smoke, vehicle exhaust fumes, pesticides and the like. Excessive exposure to the UV content of sunlight can also create free radicals as can eating barbecued and smoked foods, and exposure to carbon monoxide and peroxides. Even the biochemical conversion of glucose to energy in our bodies creates free radicals.
These free radicals can destroy body cells, including DNA, and can create conditions such as premature aging due to destruction of skin cells, destruction of brain cells, strokes, cancers, diabetes, atherosclerosis due to oxidation of LDL cholesterol that deposits in the main arteries of the body, stiffening of the joints and many other undesirable conditions.
Free radicals are destroyed rapidly by antioxidants: the reaction is very rapid and most are destroyed immediately they are formed before they can do harm. Fortunately, if your diet is well maintained, the body possesses many antioxidants such as vitamins A, C and E, and other substances such as Coenzyme Q10, flavanoids, xanthenes, polyphenols and carotenoids. Many of these are found in highly colored foods, and if your food is brightly colored, it should contain a good supply of antioxidants.
However, the problem with all of these is that they are either fat and oil soluble or water soluble, which means that they can either be freely carried round the body by the blood or have to be emulsified by the bile and transported via the lymphatic system that places restrictions on their effectiveness in certain organs of the body. The fact that alpha lipoic acid is soluble in both water and fats enables it to be carried to all parts of the body and to every organ, and can cross water/fat barriers that other antioxidants cannot do.
It can therefore be carried via the blood to the brain and carry out an essential antioxidant function within our brains. It took a long time for this property of ALA to be recognized and its consequent health benefits understood. It is, in fact, the ideal antioxidant. The substance provides many known benefits to the body due to its antioxidant properties and also helps the body to generate the maximum possible amount of energy from the blood glucose and thus improve the energy balance of your body.
However, it is with its antioxidant properties that we are most concerned here. One of the benefits of these properties is its effect in holding back the visible effects of aging on your body. Because it is both water and fat soluble, alpha lipoic acid can help destroy free radicals in every part of your skin; the areas served by the blood and the fatty and oily secretions are protected simultaneously by the same strong antioxidant. The end result is a reduction in the destruction of the cells through the dermis and epidermis and a reduction in the degree of wrinkling with age.
Its antioxidant effect in the brain renders ALA in great demand for reducing cognitive impairment with age. In fact studies have indicated that alpha lipoic acid can improve memory and brain function in the aging and the elderly. This effect appears to be increased by the synergistic combination of alpha lipoic acid and acetyl-L-CARNitine that work together to prevent cognitive decline in the brain through the effect of free radicals.
There is evidence that during a stroke, ALA works synergistically with vitamin E to reduce the effect of free radical damage on the vulnerable brain cells, and so reduce the longer term effects of the stroke. Together with ALC, it also reduces oxidative stress on the mitochondria of cells and in so doing helps once again to reduce the effects of aging, and maintain the body’s capacity to generate energy from blood glucose.
Cardiovascular disease is the main killer of the western world, largely due to our diets, and this is especially true of the USA. Although Americans appear unable to change their unhealthy diet, alpha lipoic acid and acetyl-L-CARNitine can be used to offset much of the damage done. ALA reduces the development of atherosclerosis through its antioxidant properties and the reduction of the adhesion of monocytes to the artery walls.
LDL trapped in the wall of the artery can be oxidized and enable monocytes to also enter under the surface of the arterial wall, where it changes into macrophages and ingests the oxidised LDL, causing the plaque that forms atherosclerosis. As the plaque thickens, the artery becomes increasingly restricted until the blood flow is significantly reduced or even stopped, causing cardiac failure or a stroke.
Alpha lipoic acid can prevent this free radical oxidation from occurring by destroying them before they act on the low density lipoprotein (LDL). Acetyl-L-CARNitine works with the ALA to achieve this, as does another substance known as carnosine. Between them, these three musketeers work to keep your arteries clear and your brain functioning as it should, though it is the ALA that is most powerful due to its oil and water solubility properties.
Although alpha lipoic acid is available as a supplement, either alone or in combination with acetyl-L-CARNitine, it is also available from natural food sources. It is particularly rich in offal such as heart and kidney, and also in broccoli, spinach and brewer’s yeast. It is also available in beef, and it is here that burgers can perhaps repay some of the damage that it causes. However, it is not a recommended source since burgers still cause more damage to your health than any of their constituent nutrients can allay.
Like any other supplement, you should seek medical advice before taking any substance if you have a health condition. Nevertheless, the benefits of alpha lipoic acid are such that it is difficult to see it doing anything but good. However, please consult your physician if are taking other drugs.
Natural Supplements Like Fish Oils And Phosphatidylserine Can Boost Memory
January 14, 2008 03:24 PM
We often think of our brain as being different from other organs, but the brain undergoes changes over time, just like the heart. Up until recently, brain aging and everything that goes along with it was associated with neuron failure. Actually, brain neurons do not undergo massive die-off with age. Although some neurons are lost, the brain continues to grow new ones, though at a slower pace. Decreasing cognitive function is now believed to start as early as one's late thirties, which is the result of a lowered vascular function for oxygen and nutrient supply, increased oxidative stress, and decreased production of neurotransmitters. Other issues impact memory too such as normal aging, emotional trauma, alcoholism, depression, seizures, dementias, stroke, neurodegenerative illnesses, and obesity. All of these can lead to devastating changes in mood and memory. Additionally, it is widely known that the use of cholesterol-lowering drugs can severely impact skills that involve brain functions.
The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium
May 18, 2007 01:06 PM
The Awesome Foursome: Coenzyme Q10, L-CARNitine,
The “Awesome Foursome” of Coenzyme Q10, L-CARNitine, D-Ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-CARNitine, D-Ribose, and magnesium work in synergy to promote cardiovascular health.
Energy Recycling through the Electron Transport Chain
Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.
Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.
In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.
What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.
Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-CARNitine.
Transporting the Cellular Energy Fuel
Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-CARNitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-CARNitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-CARNitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-CARNitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-Ribose can do that.
Rebuilding the Cellular Energy Pool
As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-CARNitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.
When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.
Ribose is the only compound used by the body to refill this energy pool. Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency. Ribose is made naturally in the cells from glucose. In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis. So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.
Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy. Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days. But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose. Conditions like ischemic heart disease or congestive heart failure fall into this category. In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.
Switching on the Energy Enzymes
Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism. Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work. Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is expanding.
Magnesium deficiency reduces the activity of important enzymes used in energy metabolism. Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function. Small changes in magnesium levels can have a substantial effect on heart and blood vessel function. While magnesium is found in most foods - particularly vegetables - deficiencies are increasing. Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.
Supporting the Links in The Energy Cycle Chain – the Synergy
Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.
The cell needs a large, sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-CARNitine come into play.
The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-CARNitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-CARNitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-CARNitine help the engine run properly.
Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.
These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-CARNitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.
The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.
L-CARNitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-Ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.
CoQ10 for Heart Health
March 28, 2007 12:39 PM
CoQ10 for Heart Health
More than 40% of all deaths in the
One of the most – if not the most – important things people can do to improve their overall health and life expectancy is to improve their heart health. Diet, exercise, and the wise use of dietary supplements can improve heart health dramatically. One dietary supplement that’s extremely beneficial to heart health is coenzyme Q10 (CoQ10).
Q. What is CoQ10?
A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone. That’s because CoQ10 is ubiquitous and exists everywhere there is life. CoQ10 is vital to adenosine triphosphate (ATP) production. ATP is the energy-rich compound used for all energy-requiring processes in the body. Although COQ10 is produced by the body and exists in some dietary sources, these levels may be insufficient to meet the body’s requirements. CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. Also, some drugs, especially a group of cholesterol-lowering prescription drugs known as “statin,” (Pravachol, Zocor, Lipitor, etc.) significantly reduce CoQ10 levels in the body.
Q. For what health conditions is CoQ10 used?
A. CoQ10 is beneficial in treating and preventing CVD and conditions such as high blood pressure, atherosclerosis (hardening of the arteries), angina, and congestive heart failure (CHF). It’s been shown that heart attacks tend to occur when CoQ10 levels are low in the body. In addition, CoQ10 is beneficial for diabetes, immune dysfunction, cancer, periodontal disease, prostate cancer, and neurological disease.
Q. Why is CoQ10 especially important to heart health?
A. The heart is one of the most metabolically active tissues in the body. In the average person, the heart propels 2,000 gallons of blood through 65,000 miles of blood vessls by beating 100,000 times each day. Thus, it requires large amounts of uninterrupted energy. Heart cells have a greater number of mitochondria, and subsequently, more CoQ10 than any other type of cell. Each heart cell can have thousands of mitochondria to meet these energy demands.
Mitochondria are highly specialized structures within each cell and are often referred to as cell powerhouses. These tiny energy-produces produce 95% of the energy the body requires. The number of mitochondria in a cell depends on its function and energy needs. A cell’s ATP production is dependent on adequate amounts of CoQ10.
Heart disease patients are commonly CoQ10 deficient. Correcting such deficiencies often can produce amazing results. The presence of supplemental CoQ10 is a key to the heart’s optimum performance.
In people who have had a heart attack (myocardial infarction), CoQ10 assists in repairing the heart muscle and restoring heart function. This is due to increased ATP production.
Q. What studies support this fact?
A. A 1998 study found CoQ10 can provide rapid protective effects in patients with a heart attack if administered within three days of the onset of symptoms. The study focused on patients admitted to the hospital with an acute myocardial infarction (AMI) diagnosis. Seventy-three patients received CoQ10 (120 mg/d). The study’s control group consisted of 71 similarly matched patients with acute AMI. After treatment, angina pectoris (severe chest pain signifying interrupted blood flow to the heart), total arrhythmias (dangerously irregular heartbeats), and poor function in the left ventricle (the essential chamber of the heart) were significantly reduced in the CoQ10 group compared to the placebo group. Total deaths due to sudden cardiac failure and nonfatal heart attacks also were significantly reduced in the CoQ10 group compared with the placebo group.
In another study, CoQ10 was studied in 109 patients with high blood pressure (hypertension). The patients were given varying doses of supplemental CoQ10 with the goal of attaining a certain blood level (greater than 2.0 mcg/l). Most patients were on medications to treat hypertension. Half the patients were able to stop taking one to three antihypertensive drugs at an average of 4.4 months after starting CoQ10. Only 3% of patients required the addition of one antihypertensive drug. The 9.4% of patients who have echo cardiograms, performed both before and during treatment, experienced a highly significant improvement in heart wall thickness and function. This improvement was directly attributed to CoQ10 supplementation.
Congestive heart failure (CHF) is a debilitating disease that affects 5 million people in the
Q. I’ve heard that CoQ10 can also help people who have neurological diseases. Is this true?
A. Yes, it is. CoQ10 has been studied for its ability to improve the health of individuals with amotrophic lateral sclerosis (ALS), Parkinson’s disease, and Huntington’s disease. A recently completed study sponsored by the National Institutes of Health showed that CoQ10 caused a slowing of the progression of Huntington’s disease, a devastating and degenerative disease that is always fatal. In fact, no other medication, drug, or nutritional supplemental has ever been shown to cause a decline in the progression of this terrible disease.
The study compared CoQ10 against remacemide (an investigational HD drug made by AstraZeneca Pharmaceuticals), in 347 HD patients who were in the early stages of the disease. Remacemide blocks glutamate, the neurotransmitter scientists think may cause the death of brain cells that occurs in Huntington’s disease. While remacemide had no effect on the progression of HD, CoQ10 showed a trend toward slowing the disease by an average of 15%. This meant the HD group taking CoQ10 was able to handle every day activities of life a little longer than the patients taking remacemide or a placebo. They also were able to focus their attention better, were less depressed, and less irritable. The 15% slowing of decline means that CoQ10 can result in about one more year of independence for HD patients. Needless to say, the gift of an additional year of health in the lives of HD patients is incredibly significant.
Because of these impressive results with HD, researchers are hopeful that the studies of CoQ10 in those with ALS and Parkinson’s disease will similarly have a positive effect on the symptoms and/or progression of these neurological disorders, too.
Q. Why is it crucial for a CoQ10 supplement to cross the blood-brain barrier?
A. The brains’ blood vessels are composed of cells with extremely tight junctions. These junctions form the blood-brain barrier, which restricts what can pass from the bloodstream into the brain. While this barrier protects the brain, it can be a significant obstacle to central nervous system therapy. To leave the bloodstream and reach the brain cells, a substance must pass through the tightly connected cells of the capillary walls. Only substances with unique solubilities or those with a transport system can cross the blood-brain barrier to a significant degree. As a result, crossing the blood-brain barrier presents a significant challenge to supporting neurological health.
While most CoQ10 supplements enter the bloodstream and increase blood serum levels, only special forms of CoQ10 have been shown to cross the blood-brain barrier. For CoQ10 to enter the mitochondria within the brain, CoQ10 must first cross the blood-brain barrier to produce significant neurosupportive clinical results.
Q. How can one supplement have applications for neurological diseases, heart health, and even the immune system?
A. Supplements often have more than one function, especially when it’s a substance like CoQ10, which is present in all parts of the body. All nucleated cells (most cells other than red blood cells) have mitochondria and all cells require energy to function. CoQ10 is vital to ATP production. Thus, CoQ10 has applications not only in neurological (neurons or nervous system cells) and cardiac health (myocardium or heart tissue), but also for the immune system.
Q. Are all CoQ10 supplements created equal? Doesn’t CoQ10 just have to get into the bloodstream to be effective?
A. There are some important distinctions among CoQ10 products, as they vary greatly in quality and absorbability. It’s crucial to find a CoQ10 product that’s:
1. Scientifically shown to absorb through the digestive tract, cross cellular membranes, and increase mitochondrial levels of CoQ10. Chewable forms of CoQ10 provide rapid bioavailability and absorption. Serum level determination of CoQ10 in the bloodstream is not necessarily the most important measure of efficacy. For a CoQ10 supplement to be fully effective, it must cross the cellular barrier and raise intracellular CoQ10 levels. A key indicator of effective CoQ10 supplementation is its presence in cell mitochondria.
2. The natural form of CoQ10. The natural process uses living organisms. CoQ10 also can be synthesized by a chemical process, which produces a distinctly different product that contains chemical compounds not found in the natural form.
3. Formulated with ingredients that provide the transport system CoQ10 needs to cross cellular membranes and the blood-brain barrier. Not all forms of CoQ10 have been scientifically proven to cross cell membranes and the blood-brain barrier. Some prestigious groups that have investigated this issue include researchers at
4. Studied by respected organizations, with research published in peer-reviewed journals by reputable scientists.
Q. How much CoQ10 should I take?
A. Take 100 to 200 mg of CoQ10 daily, depending on your family history of heart disease and personal heart disease experience.
CoQ10’s safety has been evaluated. Dosages in studies have ranged from 100 mg to 1,200 mg per day. To date, no toxicities have been reported. Occasional mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.
Q. What are some other heart-friendly supplements?
A. CoQ10 is an excellent supplement for overall cardiovascular health, as in L-CARNitine. L-CARNitine is the naturally occurring form of carnitine that’s found in food and synthesized in the body. Much of the body’s L-CARNitine is found in the heart and skeletal muscle, tissues that rely on fatty acid oxidation for most of their energy. Nearly 70% of the energy needed for heart function is derived from fatty acid breakdown. Proper L-CARNitine supplementation transports fatty acids into cell mitochondria, where it’s burned for energy. L-CARNitine is an excellent addition to CoQ10, especially for people with heart disease, and has been shown to improve many symptoms associated with CVD. In one study, people who had experienced one heart attack received either L-CARNitine or placebo. The L-CARNitine group had a statistically significant reduction in second heart attacks, and improved overall survival.
Q. What supplements support healthy blood pressure and cholesterol?
A. In addition to maintaining overall cardiovascular health, it’s also important to address your essential fats/lipids levels and healthy circulation/blood pressure. Fish oil supplements can significantly reduce blood pressure, cholesterol, and homocysteine levels. Choose a supplement that’s a rich source of EPA and DHA, omega-3 fatty acids naturally obtainable in fish oil. Find a product that’s been clinically studied and purified to ensure it contains the beneficial active constituents of the whole oil, while removing any dioxins, DDT, PCBs, or heavy metals, toxins present in some commercial fish oil preparations. An enteric-coated garlic product that provides a minimum of 5,000 mcg of beneficial allicin supports healthy blood pressure and circulation. And magnesium, niacin, vitamin E, folic acid, hawthorn extract, and L-cysteine provide overall nutritional support to the heart and vascular system.
CoQ10 is not the only answer to the complex issues of heart disease, neurological disease, or immune dysfunction; however, research indicates that it’s a bigger piece of the puzzle than physicians and scientists ever imagined. The more we study this naturally occurring compound, the more benefits we find.
The key to this supplement is the manufacturing quality. For safety and overall effectiveness, use a CoQ10 product that’s supported by product-specific research from reputable institutions. Choose tested products from a well-respected company to increase your potential to achieve and maintain heart and blood vessel health.
Supplementation with clinically studied products can have a major impact on your heart’s health and strength. However, no supplement replaces the need to eat a healthful diet low in refined foods (especially sugar), and saturated fats, and to exercise your most important muscle – your heart – on a regular basis.
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.
Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.
To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.
Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.
Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.
Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.
In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."
In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:
• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.
• 78.9% of subjects showed an increased mean value of hair diameter.
• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."
Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.
Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:
• Total Number of Hairs: Significantly Increased
• Total Number of Terminal Hairs: Significantly Greater
• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher
• Hair Follicle Activation: Intensive
In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.
Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.
Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.
Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.
Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.
Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.
Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.
If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.
The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.
After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.
Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.
MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.
Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.
The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.
According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.
The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.
Carnitine Tartrate - L-CARNitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.
Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.
L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.
Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.
In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.
Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.
Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.
After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.
This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Q. Is Revita safe ?
A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.
Q: Can I have my hair colored or permed while using Revita ?
A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.
Q: What is SLS/SLES free ?
A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.
Q: Can I blow dry my hair after using Revita ?
A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.
Q: Who is a candidate for Revita ?
A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.
Q: What type of results should I expect with Revita ?
A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.
Q. Does Revita have any systemic side effects ?
A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.
Q. Does Revita work for women?
A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.
Q. I am using other topical treatments. Can I use Revita at the same time ?
A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.
Q. Do I need to use Revita for a long time ?
A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.
Q: Is stress a factor in hair loss?
A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
Interview on symptoms of Fibromyalgia and one mans story
August 09, 2006 03:25 PM
Interview with Todd Williams from Source Naturals
Todd: Michael, many of us know someone with fibromyalgia, but many of us don’t know what FM is. Can you help explain the disease?
Michael: Yes. Fibromyalgia (pronounced Fie-bro-my-AL-ja) is a complex chronic pain illness that challenges patients and health care professionals alike. It is estimated that fibromyalgia affects 8 – 10 million women, men, and children in the U.S. alone. Symptoms include: extreme fatigue, sleep abnormalities, cognitive problems, difficulty speaking clearly, memory loss, brain fog, and so on. There’s also irritable bowel syndrome, restless legs, migraine headaches, neurological symptoms, anxiety and environmental sensitivities. Ninety percent of those afflicted with fibromyalgia are women. Ten percent are men. What activates fibromyalgia within a person can be anything from a thyroid condition to an auto accident, or some type of trauma or emotional stress. There is often a compromised immune system, hormonal imbalance, and even a possible enzyme deficiency. Because the stomach and intestines are made up of muscles, fibromyalgia affects the entire digestive tract. The members in my fibromyalgia support group in Santa Monica all have stomach problems. One of the doctors believes that the fibromyalgia I have to battle with daily is a result of a thyroid problem. Thyroid problems run in my family and, not surprisingly, my brother, who lives on the other side of the country has fibromyalgia as well. We correspond and share with each other what does and doesn’t work. My ten-year career as a schoolteacher came to an end due to having fibromyalgia. I lost the energy I needed to work non-stop ten-hour days. I was forced by necessity to go into early retirement. As a result, I had to find a new manageable way to live. So I then went to Los Angeles to pursue a part time acting career. Now, regardless of whether a task is big or small, I just try to do my best, one day at a time.
Todd: Michael, how did you experience the onset of Fibromyalgia?
Michael: although I’ve really had fibromyalgia for fifteen years, I wasn’t actually diagnosed by my doctor until 1996. I was very energetic and athletic while growing up. During my twenties, I first went to University of Arizona in Tucson, and then to Oral Roberts University in Tulsa, Oklahoma, and later to Point Loma University in San Diego, where I received a Master’s Degree in education. I followed that by moving to Florida to teach and to spend some time with my family. During summer breaks from teaching, I would go down to Florida Keys and visit Miami for fun. I had plenty of energy up until I was 28-30 years old, when I noticed a drastic drop in my energy level. At that time, when I would exercise, it was very difficult for my muscles to recover after a workout, even if it was a light workout. By the time I was thirty, the muscles in my feet became unbearably tight. It became very difficult to stand or even walk very far. I had my feet X-rayed, and the reports would say that nothing was wrong. When I was thiry-five, I took some antibiotics to get rid of a cold and I ended up with severe reaction to the antibiotic, erythromycin. My stomach swelled up like a balloon and felt unbearably tight. This was my first experience with IBS (Irritable Bowel Syndrome). I could no longer digest my food. I developed severe food and chemical sensitivities. I could no longer digest vitamin B properly. I would be in excruciating pain for several hours after eating almost anything. I had to leave my teaching position and I ended up being mostly bedridden for two years due to exhaustion and the inability to digest food. During this time I went to twenty doctors. I had colonoscopys, endoscopies, barium x-rays and thyroid tests, but the results were always indicating a normal range. I knew that I was horribly sick but the doctors and the tests repeatedly said that nothing was wrong with me. nevertheless, the doctors did provide more prescription medicines, especially antibiotics. It’s strange that not one of these doctors mentioned or prescribed probiotics in any form for rebuilding the flora in my intestines that was destroyed by the long antibiotic regimen. Eventually I would end up spending a large sum of money and going to 40 more doctors, with each helping just a little. It was a relief when I was finally diagnosed with fibromyalgia, because it helped me narrow in on what was really going on. Which everything falling apart, it was a relief to know it wasn’t a rare foot disease, or a stomach parasite, or AIDS. I wanted to encourage men and women who are finally diagnosed with fibromyalgia to not see it as a death notice, but rather a step in recovery. In 2002, I tried something new. I went online and submitted my medical history to Dr. Teitelbaum’s Diagnosis Program, which you can find at www.vitality101.com. His incredible program spat out about 200 pages of very insightful information on what my body was deficient in. I began taking some of his recommended supplements and began to see some definite results. In spite of my poor track record with medical tests, he also recommended thyroid testing for fibromyalgia suffers, even though it is well known that thyroid tests are frequently wrong. Dr. Teitelbaum believes that many people who have fibromyalgia were actually having a thyroid problem, even though their thyroid tests come out in the normal range. I’ve had numerous thyroid tests over the years, and they’ve all been normal. I trekked back to my doctor and pleaded with him, even mentioning that there was a history of thyroid problems in my family. At first, he refused, simply because the tests said normal. I think doctors, fearing litigation, are reluctant to try a treatment path unsupported by test results. When you think about it, test ranges are really averages. What happens if your physiology falls outside the normal average? The tragic answer is: you can fall through the cracks! Finally, after much debate and arguing, I was able to get my doctor to provide a prescription for a small dosage of thyroid medicine. I began taking it immediately after two days I began to notice that the tight muscles in my stomach and legs began to loosen up. This seemed miraculous. Unfortunately, I also had some negative side effects from the medicine, so I stopped taking it. Nevertheless, I was amazed at how my body responded to such a small does of thyroid medicine. I think Dr. Teitelbaum is onto something. If you are fortunate enough to have an open minded doctor, perhaps that avenue is worth exploring. In Dr. Teitelbaum’s book, From Fatigue to Fantastic, he also advocates supplements for helping people with Fibromyalgia and chronic fatigue. I can verify that supplements have absolutely becomes part of my program and helped with restoring my systems to their natural balance. Some supplements that really helped me are: NADH, Glutathione, L-CARNitine, Acetyl L-CARNitine, revitalizing sleep formula, daily infusion powder and calcium D-Glucarate. Please feel free to check out the full list of supplements on my website. If you are fatigued, you should really read Dr. Teitelbaum’s book. To fibromyalgia sufferers, I highly recommend checking this list, visiting these doctors’ web pages, and trying their protocols. Thanks to these doctors and various regimens, including supplements, my health is much, much better. Most people would have never guessed I went through such an ordeal. I still have to pace myself, and not push the limits. Staying healthy and maintaining my energy is a priority, so I’ve learned not to over-extend myself. I’ve learned to say no to some projects and activities and not feel guilty about it.
Todd: Wow! That’s a lot to go through. Facing such huge obstacles, how did you keep your ship facing forward?
Michael: Well, living and healing are spiritual events. I am fortunate to have a degree in theology and I have a strong daily spiritual practice, which has helped me to survive and thrive with complications of fibromyalgia. That’s not to say there haven’t been some very dark days, but faith in God and the support of my spiritual network, including my wonderful family and friends have made all the difference. After arriving at LA, I had moved into a little apartment across the street from Warner brothers. My roommate and I had decided to start a little bible study. We invited our neighbors and we prayed for many things including for my health to improve. One of our requests was for a door to open at Warner Brothers. Within a short time, our Bible Study group grew and our home couldn’t contain all the people. A year later, the doors opened for me at Warner Brothers, and I was working on the West Wing.
Todd: that’s Great! Can we tell the folks about your new show?
Michael: My web page has a new category called, “Nutrition Show”, which will provide all the details.
Todd: Thanks Mike! For more about Mike and fibromyalgia, please visit his website at: www.captainhastings.com
Benefits of taking Vitamin C Daily
July 26, 2006 02:09 PM
Vitamin C benefits
1. maintain normal connective tissue and wound healing.
2. help strengthen bones.
3. Vitamin C is a Cofactor in the production of epinephrine (adrenalin).
4. Vitamin C helps in the production of Bile acids for digestion.
5. Vitamin C helps in the production of Thyroxin (Thyroid hormone).
6. helps in the absorption of Iron.
7. aids in amino acid metabolism.
8. helps strengthens the body during infection.
9. helps counter oxidative stress.
10. may help strengthen veins and aid in diabetic retinopathy.
11. Vitamin c may help reduce the binding of glucose to proteins in diabetics.
12. in large doses Vitamin C has shown to have an antihistamine effect and may be helpful with asthma and allergies.
13. Vitamin C is needed for the synthesis of L-CARNitine, L-CARNitine helps transport fat into cells to burn as energy.
1000mgs of vitamin C each day helps keep the doctor away ;)
for proper vitamin C intake try Alacer Emergen C drinks...
HDL Booster - Boost your good cholesterol
March 16, 2006 12:51 PM
(Product No. 02922)
HDL Booster is a physician-developed dietary supplement that has been clinically shown to increase good cholesterol levels, particularly HDL-2, the best form of cholesterol.* The formula combines essential vitamins and minerals, at levels recommended by the American Heart Association (AHA), with key amino acids, powerful antioxidants, and traditional herbal extracts to provide superior support for cardiovascular health.*
· Formulated by Dr. Dennis Goodman, Chief of Cardiology at
· Clinically studied to increase good cholesterol levels up to 23%*1
· All-inclusive formula; includes ingredients recommended in accordance with the American Heart Association
· Replaces the CoQ10 depleted by cholesterol lowering (statin) drugs.*2
HDL Booster has been clinically shown to increase HDL cholesterol levels.* HDL Booster also supports healthy cholesterol and healthy triglyceride levels already within the normal ranges.* By reducing C-reactive protein levels, HDL Booster helps support the body’s natural anti-inflammatory response.*
Two tablets (one serving) contain:
Vitamin C (ascorbic acid) 148 mg
Vitamin E (as natural mixed tocopherols) 35 IU
Niacin (as niacinamide) 21 mg
Vitamin B6 (as pyridoxine HCl) 3 mg
Folic Acid 301 mcg
Vitamin B12 (as cyanocobalamin) 20 mcg
Magnesium (from magnesium amino acid chelate) 10 mg
Selenium (as L-selenomethionine) 49 mcg
Proprietary Blend 388 mg
hawthorn (Crategus oxyacantha) berry extract,
taurine, garlic (Allium sativum) bulb, grape seed (Vitis
vinifera) extract, grape skin (Vitis vinifera) extract,
N-acetyl-L-cysteine, alpha-lipoic acid, soy (Glycine
max) isoflavones, tocotrienols
L-Arginine (as L-arginine HCl) 153 mg
L-CARNitine (as L-CARNitine L-tartrate) 51 mg
Coenzyme Q10 (CoQ10)(ubiquinone 10) 25 mg
Policosanol 7 mg
Other ingredients: See label for most current information.
Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives. This product contains natural ingredients; color variations are normal.
Cholesterol, the soft, waxy substance present among the lipids (fats) in the bloodstream and in all cells, is important for wide variety of physiological functions. It is essential for the formation of cellular membranes, necessary for the production of bile salts, and also plays a role in the synthesis of certain hormones.3-5
Cholesterol is both produced by the body and obtained from food. Endogenous cholesterol is formed by human cells, particularly liver cells, whereas exogenous cholesterol is absorbed through the gastrointestinal tract from food.3,4
Because cholesterol can not be metabolized for energy, it must be removed from the body once it has served its function. The major route of removal is through the liver, where it is processed and subsequently excreted from the body.3,4
Types of Cholesterol
Cholesterol is lipophilic (“fat loving” or water insoluble) by nature. It can not be dissolved in the blood, and must, therefore, be transported by carriers known as lipoproteins. These carriers are classified by density, with LDL (low density lipoproteins) and HDL (high density lipoproteins) being the most common.4,5
LDL is often referred to as “bad” cholesterol. LDLs carry cholesterol throughout the body. Conversely, HDL, or “good” cholesterol, is responsible for carrying cholesterol away from the arteries to the liver where it is eventually processed and eliminated from the body.3,4,6
Scientific studies have shown that both types of cholesterol are important indicators of cardiovascular health. But recent research, focusing on the beneficial subtypes of HDL, has found that certain fractions of HDL may be more supportive of cardiovascular health than others. The two most notably supportive HDL fractions are HDL-2 and HDL-3.7
The smaller HDL-3 is synthesized by the liver and intestines. This form, which is known as “free cholesterol-rich” HDL, scavenges or “scoops up” free cholesterol. The cholesterol is then chemically altered by the addition of an ester group. When sufficient cholesterol is esterified, HDL-3 becomes HDL-2, which is therefore referred to as “cholesterol ester-rich” HDL. HDL-2 is larger in size and has been shown to be more cardiosupportive than HDL-3.*7
HOW IT WORKS:
HDL is known to possess antioxidant activity and to help balance the body’s natural anti-inflammatory response, both of which are important for cardiovascular health, but its most important function is the role it plays in cholesterol transport.6,8 High levels of HDL cholesterol are also associated with reduced platelet activity, another key indicator of arterial and venous health.9
Both HDL and LDL levels are important indicators of healthy cardiovascular function.* Therefore, supplements that increase the level of good cholesterol can profoundly impact heart health.* In 2002, an open label pilot study was conducted at
The following chart summarizes the benefits of each of the ingredients in HDL Booster:
Benefits of L-Carnitine
February 12, 2006 03:24 PM
Benefits of Acetyl-L-Carnitine
February 12, 2006 01:55 PM
L-Carnitine L-Tartrate Inhibits Gestational Diabetes
January 24, 2006 05:15 PM
Vienna, Austria—Intake of L-CARNitine L-tartrate during pregnancy may thwart a sequence of reactions leading to gestational diabetes, according to a study published in Chemical Monthly (136, 8:1523-1533), 2005) (www.springerlink.com).
Scientists from the University of Vienna noted deficiency of carnitine in pregnant women from the 12th week of gestation through delivery leads to down-regulation of expression of certain enzymes involved in fatty acid metabolism; loMRNA levels of these enzymes promotes an increase in free fatty acid levels conducive to insulin resistance. The researchers found supplementation with L-CARNitine L-tartrate (as L-CARNipure, from Lonza) increased relative mRNA levels of these enzymes in pregnant women.
In a release on the findings, Lonza (www.lonza.com) noted there appears to be increasing evidence that L-CARNitine may play an important role during pregnancy, particularly in women following a meat-reduced or vegetarian diet.
Molecularly Distilled Omega-3 fish Oil Fact Sheet
January 12, 2006 03:28 PM
Molecularly Distilled Omega-3 fish Oil Fact SheetNeil E. Levin, CCN, DANLA 10/26/04
LIKELY USERS: Everyone consuming fast foods or diets high in vegetable oils; People with family history of heart disease or diabetes; People with inflammatory conditions
KEY INGREDIENT(S): Molecularly distilled fish oil concentrate
MAIN PRODUCT FEATURES:
OTHER IMPORTANT ISSUES:
Molecular distillation removes impurities such as pesticides (PCBs, PCDFs, PCDDs, Dioxin) and heavy metals (mercury, lead)
AMOUNT TO USE: One teaspoon a day provides 740 mg. of EPA and 475 mg. of DHA. Use one or more teaspoons per day.
SYNERGISTS: Other supplements used as cardiotonics include Vitamin E, CoQ10, magnesium, antioxidants, garlic, ginger, cayenne pepper, L-CARNitine and hawthorn leaf and flower extract.
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. But no cautions have been noted to date for pregnant or nursing women using fish oils, which are often recommended for pregnant and nursing women.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
L-Carnitine Plus B-6
January 07, 2006 01:06 PM
L-CARNitine Plus B-6: A powerful fat metabolism regulator that accelerates fat oxidation and produces ATP for high energy. This formula lowers body fat for enhanced definition.
Now Foods -QUALITY- High Standards and Attention to Detail
December 27, 2005 09:00 AM
QUALITY “High Standards and Attention to Detail”
As you shop for dietary supplements you’re faced with an almost dizzying array of choices. Naturally, every product claims to be this, that and the other. But you’ve heard the stories in the media of products that don’t live up to their claims. So how do you know who’s telling the truth? Perhaps a better gauge of a product’s quality is the manufacturer and their history. Do they have a legacy of producing quality goods? How long have they been in business? Is their track record good or do they have a history of product recalls and bad press? If you’re responsible for your family’s health and well-being, it pays to do your homework when it comes to the products you purchase for them. NOW® Foods has been manufacturing dietary supplements and whole foods for 35 years.
Companies that thrive and continue to grow for this long don’t do so because they produce poor quality products. They do so by maintaining extremely high standards and paying special attention to every detail, which is the secret to product quality. At NOW® Foods, these high standards and attention to detail are evident in every aspect of our operations, from receiving to production to finished goods, just as they have been for 35 years. You’re committed to buying only the best for your family, and we’re committed to supplying only the best for our customers.
Quality products are made using the highest quality ingredients. NOW Foods purchases raw materials from only the most reputable vendors, who are required to provide detailed specification sheets and lot-specific certificates of analysis for every shipment we receive. These documents provide information on the quality of the raw material and the various analyses used to verify that quality. Shipments that do not meet our quality standards are sent back to the manufacturer with a point by point report card of why the shipment was refused. We simply don’t just accept every shipment that’s delivered to our dock – no ingredient gets a free pass into our production facility. In addition, we also perform random vendor audits throughout each year to ensure that they’re meeting our stringent quality standards. NOW ® Foods is always vigilant when it comes to quality, just as you are. Another way we maintain high quality standards is by choosing to buy and incorporate registered and/or trademarked ingredients into our products. Each of these ingredients are exclusively produced by a company that owns proprietary manufacturing rights and licenses selected companies like NOW® to use these top quality ingredients in their products.
These registered/trademarked ingredients must undergo even more rigorous analysis and controls than other ingredients, and so offer additional assurance that products containing them are properly manufactured and labeled. Additionally, to maintain the integrity of their ingredient’s reputation, the trademark owner will independently test finished products from manufacturers to verify the quality meets their standards and the label claim of the company licensed to use it. You may be familiar with some of the trademarked ingredient NOW® uses such as, Ester-C® vitamin C, Chromemate® Chromium and L-CARNipure® Carnitine.
Scientific analysis of ingredients is extremely important to ensure the integrity of any dietary supplement. NOW Foods has made substantial investments in the development, construction and staffing of numerous inhouse laboratories, including an advanced instrumental analysis laboratory, a “wet lab” and a state-of-the-art microbiology lab. This saves us the time and expense of having to send samples out to commercial labs for analysis. While we use independent labs to verify our in-house test results, our capabilities allow us greater control over product quality and quicker approval of raw material shipments for production, which means fresher products for consumers. Our investment ensures that NOW® will be able to meet ever-increasing demands for accurate product analysis and outstanding product quality. NOW® is unique in the industry in that we annually spend more on Quality Assurance & Control than we do on Marketing and Advertising combined. What good is a lab without qualified people? NOW® employs an expert team of highly qualified scientists and technicians, including four Ph.D.’s. They’re constantly working to develop new and improved analytical methods, and their efforts contribute not only to our product quality but that of the entire industry as well.
This is all great, you say, but what about your facility and the equipment you use to manufacture products? Our 203,000 square foot facility is designed and built to standards that exceed food-packaging guidelines. It supports pharmaceutical-grade operations, which greatly enhances our ability to produce the highest quality products quickly. All this means fresher, more effective products on store shelves for consumers. NOW® Foods is an ‘A’ rated GMP-certified manufacturer, one of the first companies in the industry to attain GMP (Good Manufacturing Practices) certification. We’re also certified by QAI (Quality Assurance International) as an organic manufacturer. As consumers become increasingly demanding of supplement quality and safety, NOW® is ready to meet this demand with sound science and state-of-the-art research, manufacturing, and packaging capabilities. We are certain that our efforts to consistently maintain the highest product quality will help make your natural product purchasing decisions easier.
December 08, 2005 03:33 PM
Carnitine CreatinateNeil E. Levin, CCN, DANLA 6/30/05
LIKELY USERS: Athletes, Bodybuilders, Dieters, People who consume a lot of fat, People needing cardiovascular support (energy for the heart), People who need quick energy, especially for fast muscle response, People with muscle wasting problems (including the elderly), Weightlifters
KEY INGREDIENTS: L-CARNitine and Creatine Monohydrate
MAIN PRODUCT FEATURES: Carnitine Creatinate Monohydrate is a specialized form of Creatine bonded to L-CARNitine. Creatine is a compound natural to the human body that aids in the regeneration of ATP, the chemical energy used by muscle tissue. During exercise, large quantities of creatine are irreversibly consumed. Clinical studies have shown that oral supplementation with Creatine can increase the amount of Creatine available in muscles for ATP production. L-CARNitine is an amino acid that is necessary for the transfer of fatty acids into the fat-burning parts of the cell, facilitating energy production from fat. The combination of these two compounds can produce a synergistic effect, making NOW® Carnitine Creatinate an ideal energy supplement.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: Carnitine and Creatinate Monohydrate is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product. Protected by U.S. Patent No. 5,994,581 (L-CARNitine Creatinate Monohydrate).
Look at the price: this is a better way to buy both supplements than purchasing them separately.
This formula is suitable for vegetarians and is offered in both tablet and powder forms.
SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, every two tablets provide 1,000 mg. (one gram) each of both L-CARNitine and Creatine Monohydrate. Or one teaspoon provides 1,150 mg.) each of both L-CARNitine and Creatine Monohydrate. Take one or more servings per day with a carbohydrate source, such as fruit juice or sports drinks.
COMPLEMENTARY PRODUCTS: CoQ10, carbohydrates, B-Complex vitamins, chromium, vanadium, Hawthorn leaf and flower extract, protein supplements. Adaptogenic herbs: ginsengs, Eleuthero, Rhodiola, Maca, Ashwaganda, licorice root
PRODUCT SPECIFIC: This product is very sensitive to moisture. Please keep in the original packaging or in a moisture resistant container. Do not take more than 20 grams per day. Discontinue use if cramps of stomach upset occur, especially if taking large doses. Do not take if kidney disease is present. Do not use large doses of caffeine with creatine, as it may increase the possibility of muscle cramping.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems.
Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Fang S-M (1998) Carnitine Creatinate. U.S. Patent 5,994,581.
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Broquist HP (1994) Carnitine, in Modern Nutrition in Health and Disease, 8th ed., Shils ME, Olson JA, Shike M (eds.) Lea & Febiger, Philadelphia, pp. 459-465. Casey A, Greenhoff PL (2000) Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am J Clin Nutr 72(suppl):607S-17S. Columbani P, Wenk C, Kunz I, et al. Effect of L-CARNitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double blind crossover field study. Eur J Appl Physiol 1996;73:434-9.
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Yesilipek MA, Hazar V, Yegin O. L-CARNitine treatment in beta thalassemia major. Acta Haematol 1998;100:162-3. CREATINE MONOHYDRATE: Almada A, Mitchell T, Earnest C. Impact of chronic creatine supplementation on serum enzyme concentrations. FASEB J 1996;10:4567.
Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc 2000;32:654-8.
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Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci 1996;91:113-8.
Earnest C, Almada A, Mitchell T. Influence of chronic creatine supplementation on hepatorenal function. FASEB J 1996;10:4588.
Earnest CP, Snell PG, Rodriguez R, et al. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand 1995;153:207-9.
Felber S, Skladal D, Wyss M, et al. Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study. Neurol Res 2000;22:145-50.
Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutr Rev 1999;57:45–50.
Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in man. Am J Physiol 1996;271:E821–6.
Green AL, Simpson EJ, Littlewood JJ, et al. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 1996;158:195-202.
Greenhaff PL. Creatine and its application as an ergogenic aid. Int J Sport Nutr 1995;5:94-101.
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Greenhaff PL, Bodin K, Soderlund K, et al. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol 1994;266:E725-30.
Greenhaff PL, Casey A, Short AH, et al. Influence of oral creatine supplementation on muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci 1993;84:565-71.
Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 1992;83:367-74.
Hultman E, Soderlund K, Timmons J, et al. Muscle creatine loading in man. J Appl Physiol 1996;81:232–7.
Juhn MS, O’Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593–5.
Kreider RB, Ferreira M, Wilson M, et al. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc 1998;30:73-82.
Poortmans JR, Auquier H. Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol 1997;76:566–7.
Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108–10.
Pritchard NR, Kaira PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252–3 [letter].
Sewell DA, Robinson TM, Casey A, et al. The effect of acute dietary creatine supplementation upon indices of renal, hepatic and haematological function in human subjects. Proc Nutr Soc 1998;57:17A.
Silber ML. Scientific facts behind creatine monohydrate as a sports nutrition supplement. J Sports Med Phys Fitness 1999;39:179–88 [review].
Sipila I, Rapola J, Simell O, et al. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N Engl J Med 1981;304:867-70.
Stone MH, Sanborn K, Smith LL, et al. Effects of in-season (5-weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr 1999;9:146-65.
Stout JR, Eckerson J, Noonan D, et al. The effects of a supplement designed to augment creatine uptake on exercise performance and fat-free mass in football players. Med Sci Sports Exerc 1997;29:S251.
Tarnopolsky MA. Potential benefits of creatine monohydrate supplementation in the elderly. Curr Opin Clin Nutr Metab Care 2000;3:497-502 [review].
Tarnopolsky M, Martin J. Creatine monohydrate increases strength in patients with neuromuscular disease. Neurology 1999;52:854-7.
Tarnopolsky MA, Roy BD, MacDonald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 1997;20:1502-9.
Toler SM. Creatine is an ergogen for anaerobic exercise. Nutr Rev 1997;55:21-5 [review].
Vandenberghe K, Gills N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452–7.
Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol 1997;83:2055-63.
Walter MC, Lochmuller H, Reilich P, Klopstock T, Huber R, Hartard M, Hennig M, Pongratz D, Muller-Felber W. Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study. Neurology. 2000 May 9;54(9):1848-50. PMID: 10802796
Walter MC, Reilich P, Lochmuller H, Kohnen R, Schlotter B, Hautmann H, Dunkl E, Pongratz D, Muller-Felber W. Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study. J Neurol. 2002 Dec;249(12):1717-22. PMID: 12529796
TMG Fact Sheet
December 07, 2005 02:13 PM
TMG Fact SheetNeil E. Levin, CCN, DANLA 03/07/05
LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups.
MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule L-CARNitine.
TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals.
Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot.
ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid.
TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures.
DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably.
SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed.
COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement.
People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG.
This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
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Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61.
Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5.
Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93.
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Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203
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Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329
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Autism & Seizures:
Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.
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CLA Extreme Fact Sheet
December 07, 2005 12:59 PM
CLA Extreme Fact Sheet Neil E. Levin, CCN, DANLA 01/31/05
LIKELY USERS: People wanting to control body fat; People wanting to increase their body’s lean mass (muscle tissue); People wanting an oil that helps to reduce pro-inflammatory body chemicals; Those wanting to prevent undesirable cellular changes through diet KEY INGREDIENT (S): CLA from safflower oil, L-CARNitine amino acid, Guarana Seed extract (20% naturally occurring caffeine), Green Tea extract (40% polyphenols), Chromium Picolinate
MAIN PRODUCT FEATURES: Conjugated Linoleic Acid (CLA) is a derivative of linoleic acid, an essential fatty acid. The softgel is formulated with CLA (derived from safflower oil), Green Tea extract (polyphenols), Guarana extract (caffeine), L-CARNitine, and Chromium (III) Picolinate for synergistic effects of reducing body fat and increasing lean muscle mass.
OTHER IMPORTANT ISSUES: One study, titled "Efficacy and Safety of One-Year Supplementation with Conjugated linoleic Acid in Moderate Overweight," found that compared to placebo, CLA-supplemented subjects had Body Fat Mass index scores averaging 9% lower than the placebo group and had Lean Body Mass results showing lean muscle mass averaging 2% more than the placebo group. Analyses of blood tests showed no side effects over this one-year period. CLA plus Guarana reportedly reduces the size and number of fat cells in another report. CLA may also reduce insulin resistance and prevent undesirable cellular changes.
AMOUNT and HOW TO USE: One to five capsules a day, preferably with meals.
COMPLEMENTARY PRODUCTS: Alpha Lipoic Acid, Vitamin E, other Antioxidants
CAUTIONS: CLA may reduce insulin resistance, so people on blood sugar medications may not need as much of their drugs. Use with caution to avoid an overdose of your blood sugar medication when using this oil. Please notify your physician about your supplement use if you are using any drugs!
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am. J. Clin. Nutr. 79(6):1118–1125 (2004).
Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams CM, Calder PC, Yaqoob P. Effects of cis-9,trans-11 and trans-1 0,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am. J. Clin. Nutr. 80(6):1626–1633 (2004).
Aminot-Gilchrist DV, Anderson HDI. Insulin resistance-associated cardiovascular disease: potential benefits of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1159S–1163S Suppl. S (2004).
Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui YZ, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127(3):777–791 (2004).
Bergamo P, Luongo D, Rossi M. Conjugated linoleic acid - Mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. Cell Physiol. Biochem. 14(1–2):57–64 (2004).
Bouthegourd JC, Martin JC, Gripois D, Roseau S, Tome D, Even PC. Fat-depleted CLA-treated mice enter torpor after a short period of fasting. Appetite 42(1):91–98 (2004).
Brown JM, Boysen MS, Chung S, Fabiyi O, Morrison RF, Mandrup S, McIntosh MK. Conjugated linoleic acid induces human adipocyte delipidation - Autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J. Biol. Chem. 279(25):26735–26747 (2004).
Cheng WL, Lii CK, Chen HW, Lin TH, Liu KL. Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappa B pathway. J. Agric. Food Chem. 52(1):71–78 (2004).
Choi JS, Jung MH, Park HS, Song JY. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 20(11–12):1008–1017 (2004).
Cortes HN. CLA and body composition: Research shows conjugated linoleic acid can help maintain a healthy balance between lean muscle and body fat. Agro Food Industry Hi Tech 15(2):49–51 (2004).
Dauchy RT, Dauchy EM, Sauer LA, Blask DE, Davidson LK, Krause JA, Lynch DT. Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. Cancer Lett. 209(1):7–15 (2004).
Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med. Sci. Sport Exercise 36(5):814–820 (2004).
Field CJ, Schley PD. Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Am. J. Clin. Nutr. 79(6):1190S-1198S Suppl. S (2004).
Hirao A, Yamasaki M, Chujo H, Koyanagi N, Kanouchi H, Yasuda S, Matsuo A, Nishida E, Rikimaru T, Tsujita E, Shimada M, Maehara Y, Tachibana H, Yamada K. Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats. J. Nutr. Sci. Vitaminol. 50(1):9–12 (2004).
Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 323(2):679–684 (2004).
Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions. Lipids 39(7):611–616 (2004).
Lamarche B, Desroches S. Metabolic syndrome and effects of conjugated linoleic acid in obesity and lipoprotein disorders: the Quebec experience. Am. J. Clin. Nutr. 79(6):1149S–1152S Suppl. S (2004).
Malpuech-Brugere C, Verboeket-van de Venne WPHG, Mensink RP, Arnal MA, Morio B, Brandolini M, Saebo A, Lassel TS, Chardigny JM, Sebedio JL, Beaufrere B. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Res. 12(4):591–598 (2004).
McCann SE, Ip C, Ip MM, McGuire MK, Muti P, Edge SB, Trevisan M, Freudenheim JL. Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB study). Cancer Epidemiol. Biomarkers Prevent. 13(9):1480–1484 (2004).
Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am. J. Clin. Nutr. 80(4):887–895 (2004).
Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KWJ. Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis 25(7):1185–1191 (2004).
O'Shea M. Clarinol(TM) CLA (Conjugated Linoleic Acid): the weight of evidence supports a safe and efficacious product for weight management. Agro Food Industry Hi-Tech 15(4):24–26 (2004).
O'Shea M, Bassaganya-Riera J, Mohede ICM, Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1199S–1206S Suppl. S (2004).
Rainer L, Heiss CJ. Conjugated linoleic acid: Health implications and effects on body composition. J. Am. Dietetic Assoc. 104(6):963–968 (2004).
Life is more enjoyable when your stomach is prepared for it.
November 28, 2005 12:05 PM
Help the stomach at Vitanet
PepZin GI™ helps relieve occasional discomfort.
September 20, 2005 05:40 PM
PepZin GI™ helps relieve occasional discomfort.* CLINICAL TRIALS
In a randomized, multi-center, placebo-controlled double blind study, 299 patients suffering with symptoms of gastric discomfort were randomly allocated to receive either a zinc-L-CARNosine complex or a placebo, or a control drug or its placebo for 8 weeks. Improvement ratings for a range of symptoms were taken at various points during the trial and compared with before treatment data. Of the 258 people who completed the trial, 136 were in the zinc-Lcarnosine group. Of the group, 92% of the participants were rated as “moderately improved” or better on an improvement scale across the category of symptoms including heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.3
In another study, 28 patients with gastric discomfort were given a zinc-L-CARNosine compound and monitored for 8 weeks. Improvement was rated on a scale of subjective and objective symptoms. After 4 weeks, the rate of those cases that were considered to be “significantly improved” was 68.4%. After eight weeks, the “significantly improved” number was 68.8%. Over 60% of these patients remained in the “significantly improved” category well after discontinuation of the treatment, suggesting a lasting effect of the zinc-L-CARNosine compound beyond the time it is taken.4
Maintains a healthy GI environment.*
The mineral zinc in PepZin GI™ is a critical component to a number of physiological processes in our bodies. Some of these functions include growth and metabolism of cells, healing of wounds,and maintenance of carbohydrate and lipid metabolism.2
PepZin GI™ may also be able to favorably maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-CARNosine co m pound may have effects on certain strains of harmful bacteria and, therefore, may be able to help maintain a GI environment that is favorable to health.1 By supporting the bacterial balance in the stomach, PepZin GI™ can help maintain a healthy mucosal lining.
Supports the health of gastric cells.*
PepZin GI™ has been studied for its ability to prevent free radical damage to gastric cells. In one such study, rat gastric cells were exposed to ethanol and hydrogen peroxide, two substances known to cause free radical damage to living cells. Cells were bathed in hydrogen peroxide, ethanol, zinc-L-CARNosine, or a combination of zinc-L-CARNosine with either ethanol or hydrogen peroxide. While the cells bathed in ethanol and hydrogen peroxide solutions all exhibited signs of damage due to free radical production, the cells that were bathed in zinc-L-CARNosine were largely protected from the effects of free radical damage. The authors concluded that the zinc compound directly protected gastric mucosal cells from oxidant stress and alcohol induced damage.5
Additional research further confirms the gastro-protective effects of PepZin GI™. In another rat study, stomach lesions were induced by administration of the chemical monochloramine, a known pro-oxidant (producer of free radicals). One of the groups of rats was fed the zinc-Lcarnosine compound prior to being exposed to monochloramine. The researchers found that the size of the lesions in the group pre-treated with zinc-L-CARNosine was significantly less than the lesions in the control group. The authors concluded that the zinc compound exerted a beneficial protective effect against monochloramine-induced stomach lesions.6
The zinc-L-CARNosine in PepZin GI™ has also been shown to slow the development of aspirin induced stomach damage in rats. The researchers measurably detected lower levels of TNF-alpha in rats given zinc-L-CARNosine as compared to the control rats. TNF-alpha is an inflammatory cytokine that is known to be released in response to gastric damage.7 These results may suggest a role for PepZin GI™ in protecting gastric cells by occasionally reducing the levels of certain cytokines in minor inflammation of the stomach.
1. Kuwayama H, et al. Polaprezinc. Nippon Rinsho 2002 Feb; 60 Suppl 2:717-720. 2.Matsukura T,Tanaka H. Applicability of zinc complex of L-CARNosine for medical use. Biochemistry (Moscow) 2000;65(7):817-823. 3.Miyoshi A, et al. Clinical evaluation of Z-103 on gastric ulcer - a multicenter double-blind comparative study with cetraxate hydrochloride. Jpn PharmTher 1992;20(1):199-223. 4.Misawa T, et al. Clinical study of Z-103 - clinical effects on gastric ulcer and influence on endocrine function. Jpn PharmTher 1992; 20(1):245-254. 5. Hiraishi H, et al. Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacl Ther 1999;13:261-269. 6. Kato S, Nishiwaki H, et al. Mucosal ulcerogenic action of monochloramine in rat stomachs: effects of polaprezinc and sucralfate. Dig Dis Sci 1997;42(10):2156-2163. 7.Naito Y, et al. Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis Sci 2001;46(4):845-851.
Solaray - Acetyl L Carnitine - Sustain the Brain
September 13, 2005 06:59 PM
Give your brain the boost it needs with Acetyl L Carnitine naturally produced by the body to metabolize fatty acids in the heart and brain, Acetyl L Carnitine supplies your cells with much needed energy and may play a key role in supporting natural, healthy cognitive and cardiovascular function.
Make the smart choice and choose Acetyl L Carnitine.
Why Acetyl L Carnitine?
New Solaray Acetyl L Carnitine
Doctors Reject Dietary Supplement as Diabetes Treatment
July 27, 2005 10:27 AM
Doctors Reject Dietary Supplement as Diabetes Treatment
(2/23) SUZANNE LEIGH c.1999 Medical Tribune News Service
Doctors say they will not be recommending a drug that has been found to improve insulin resistance in type 2 diabetics.
In a study published in the current issue of the Journal of the American College of Nutrition, patients with type 2 diabetes had less insulin resistance after undergoing an infusion of the amino acid L-CARNitine.
Oral and injectable forms of this amino acid _ which is produced naturally in the liver_ are already prescribed as the drug levocarnitine for patients with carnitine deficiency. The drug also is available as a dietary supplement. Makers claim it can enhance athletic performance and protect against liver, kidney and heart disease.
Unlike patients with type 1 diabetes, who do not produce insulin, patients with the type 2 variation may manufacture adequate levels of insulin but develop resistance to its effects. Insulin is essential for the transportation of blood sugar, or glucose, into cells so they can produce energy.
Dr. Geltrude Mingrone and colleagues from the Catholic University in Rome evaluated the effects of insulin and L-CARNitine on 15 type 2 diabetics and 20 healthy volunteers.
Earlier studies cited in the report found that L-CARNitine improved heart function in diabetics and increased the level of glucose oxidation, a process that helps cells make use of glucose. The researchers found that both the diabetic group and the healthy volunteers experienced an 8-percent increase in glucose use with L-CARNitine compared with a placebo.
This 8-percent increase compares modestly with a previous study using a higher dose of L-CARNitine that found glucose use was increased by 17 percent. Dr. Richard K. Bernstein, director of the New York Diabetes Center in Mamaroneck, said the study demonstrated benefits that were ``only slightly higher than marginal."
Bernstein said that he prescribed L-CARNitine with some success to patients with poor circulation, but did not expect to recommend it for insulin resistance. ``If we were to see an increase of 50 percent in glucose utilization, then we might want to look at the study more closely,"
Doctors said they would continue to prescribe drugs like metformin and troglitazone for insulin resistance. Dr. David M. Nathan, director of the Diabetes Center and the General Clinical Research Center at Massachusetts General Hospital in Boston, said he was satisfied with the safety and effectiveness of both drugs provided the patient was monitored at regular intervals for kidney and liver function.
Natural Health for a Healthy Heart
July 13, 2005 09:17 AM
Natural Health for a Healthy Heart
Cardiovascular disease is on the rise. Heart disease, stroke, and related disorders kill more Americans than any other ailments combined. In 1990 approximately one million Americans died form cardiovascular disease. Arteriosclerosis (hardening of the arteries) is the leading cause of heart attacks and strokes. Fat and cholesterol accumulate around the heart and inner walls of the arteries. This causes blood flow to slow and blood pressure to rise. Blood clotting is also a problem when the arteries are clogged which, if a clot breaks loose, can cause strokes or heart attacks according to where they end up. Heart disease is usually advanced before a problem arises. Prevention should be the first goal.
Heart disease is much less common in “primitive” societies. This is due in part to the lifestyle and diet choices of Americans. Diet is viewed as the most important factor in heart related disorders. An increased intake of sugar, refined flour and simple carbohydrates may also be contributing factors. Other risk factors include a family history of heart disease, cigarette smoking, high blood pressure, type A personality, stress, diabetes, obesity, high blood cholesterol levels, physical inactivity and coronary artery disease. Changes must be made in diet and life-style in order to prevent heart disease.
Following a diet low in animal fat and refined sugars but high in fiber is highly recommended. Whole grains, almonds, fresh fruits and vegetables, a variety of legumes, skinless turkey, chicken and fish should be the main dietary elements. Brown rice, garlic, onions, olive oil, raw fruits and vegetables, sprouts, asparagus, apples, bananas, beans, buckwheat, seeds, whey powder, and yogurt are especially good for the heart. Avoid caffeine, alcohol, red meat, refined carbohydrates, and white flour. Limit intake of dairy products which contain high amounts of fat. Homogenized dairy products contain an enzyme called xanthine oxidase which is believed to cause artery damage and could lead to arteriosclerosis. Use olive oil and canola oil when using fat. Avoid palm oil, coconut oil, peanut oil and cottonseed oil.
Choline, inositol and lecithin: These act as fat emulsifiers in the bloodstream and can help prevent plaque buildup.
Chromium: Chromium is known for recent studies linking it to a reduced risk of heart disease. It may help prevent plaque buildup in the arteries. Low levels of chromium are thought to be a risk factor for developing heart disease. It also may help increase the beneficial HDL cholesterol and aid in lowering the LDL cholesterol.
Coenzyme Q10: This can help oxygenate the heart muscle helping to prevent additional heart damage. Coenzyme Q10 can help the body break down fatty acids converting them to energy. This is often lacking in individuals with heart problems. Essential Fatty Acids: These can help prevent hardening of the arteries by preventing the blood cells from clumping together and forming clots. They also help with the assimilation of fat soluble vitamins.
Germanium: Germanium has been found to lower high blood pressure and improve circulation in the body. Calcium and Magnesium: Both of these minerals contribute to the muscular contraction and relaxation of the heart. They are essential for the proper function of the heart muscle and maintaining normal heart rhythm and blood pressure. Low levels of calcium have been linked to high blood pressure.
L-CARNitine: This is an amino acid that can help the heart by reducing fat levels in the blood. Vitamin C with bioflavonoids: Vitamin C helps prevent blood clots and strengthens the capillary and blood vessel walls. It may help prevent high blood pressure, arteriosclerosis, lower cholesterol, repair arterial walls, and contribute to reversing heart disease.
Vitamin E: Vitamin E is well known for its beneficial effect on the heart. Selenium: Low levels of selenium have been associated with heart disease.
Hawthorn: This herb is great for cardiovascular health. Garlic: Garlic is one of the most studied herbs for cardiovascular health. Several recent studies link garlic to lower incidence of cardiovascular disease.
Cayenne: This is also known as capsicum and is beneficial on circulation and cleaning and nourishing the blood vessels.
Ginkgo: Ginkgo relaxes the blood vessels and improves the flow of blood even in constricted arteries. Rosemary Tea: This is a traditional heart tonic that helps to promote circulation and lower blood pressure. Chinese Mushroom (auricularia polytricha): This is a natural blood thinner.
It is important to include exercise in the daily routine. Aerobic exercise is known to help improve the heart1s pumping ability, reduce serum cholesterol levels, decrease the risk of heart disease, and reduce the risk of high blood pressure as well as many other ailments. Exercising an average of three to five days a week for thirty minutes will benefit the body. Actually any amount of exercise is beneficial for the body, so try and do something each day.
Include relaxation techniques to reduce stress. Stress can increase the risk of heart disease. Stress releases adrenaline which causes the heart to work harder. If you feel resentment, fear or anger, find ways to deal with these in a positive way. Pursuit serenity and peace in life. Exercise, self hypnosis, biofeedback, meditation, yoga and prayer can all help develop inner peace.
Supplement Efforts - to increase weight loss...
July 07, 2005 11:41 AM
If you're searching for a pill that magically melts away the pounds safely and quickly, allowing you to pig out on cookies and chips every night without having to walk a step or lift a weight, keep looking-- it doesn't exist. (If anyone tells you it does, lace up those high-tech sneakers and run in the opposite direction.) That being said, there are supplements that some folks find helpful in addition to (not instead of) a healthy diet and adequate exercise:
Don't forget a good, all-purpose multivitamin/mineral to make sure you're not missing anything nutritionally. (For in-depth information on another weight-loss option, Coleus Forskolii.) It's always a good idea to get a knowledgeable health practitioner's assistance in designing a supplementation program, especially if you are looking to lose weight because of a pre-existing health condition.
NEW PRODUCT ANNOUNCEMENT
July 05, 2005 06:29 PM
The Most Comprehensive Antioxidant Formula Available!
Four tablets contain: Vitamin A (as beta-carotene 8,500 IU & palmitate 4,000 IU) 12,500 IU
gamma-Vitamin E Complex 500 mg
Quercetin 100 mg
RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available
June 24, 2005 05:34 PM
The average American’s life expectancy has risen dramatically over the last 100 years. Ideally those extra years will be quality ones. High levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help. Free radicals cause oxidative stress, which is a major cause of accelerated aging. Source Naturals presents the science of RENEWAL ANTIOXIDANTS. This Bio-Aligned Formula™ is a significant advancement over other products currently available. No other formula provides the broad range of high potency, established and newly discovered water and fat-soluble antioxidants that RENEWAL ANTIOXIDANTS delivers.
Bio-Aligned Antioxidant Support
RENEWAL ANTIOXIDANTS™ supports multiple body systems with a balanced spectrum of plantioxidants™ (botanical extracts with unparalleled ability to combat free radicals), vitamins and specialty nutrients that have powerful antioxidant properties. Research suggests dietary antioxidants help balance and modulate free radical activity and help maintain structure and function of important components of cells such as lipids, proteins, and DNA.
Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to cells and tissues. Free radicals are unpaired electrons that can damage cells and compromise the function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of lipid and water soluble antioxidants to minimize this negative effect. No other antioxidant formula follows the science better than RENEWAL ANTIOXIDANTS to defend against the widest spectrum of destructive free radicals, including peroxyl, hydroxyl, and superoxide radicals, and singlet oxygen.
Antioxidants neutralize destructive free radicals and support cardiovascular health by halting the oxidation of cholesterol. Cholesterol is only harmful to us if it becomes oxidized. Oxidized cholesterol is an unstable molecule that damages arteries. RENEWAL ANTIOXIDANTS contains hearthealthy antioxidants including gamma E and tocotrienols, which are major lipid-soluble antioxidants that help maintain the integrity of cell membranes by preventing lipid oxidation. The formula includes hawthorn berry and grape seed, CoQ10, lycopene and other powerful antioxidants for heart support.
Nourishing the Brain
Antioxidants are critical for brain and nerve tissue because the brain is mostly composed of fats, which are very sensitive to free radical damage. Research has shown that stress can directly set in motion mechanisms that promote aging, which affects brain and nerve tissue. Ginkgo has been shown to increase memory performance and learning capacity as well as improve blood flow. It is also a free radical scavenger. RENEWAL ANTIOXIDANTS also contains DMAE, bilberry, CoQ10, grape seed, lipoic acid, vitamin B-2 and lutein for broad spectrum support.
Powerful antioxidants help minimize stress damage to liver cells and tissues, thereby supporting detoxification. N-acetyl cysteine is a powerful antioxidant. It is also a precursor to glutathione, a critical antioxidant and detoxifying substance produced in the liver. Silymarin is known for supporting the regeneration of the liver. Since the liver is prone to fat incursion, which makes it vulnerable to oxidative damage, the following fat soluble antioxidants provide critical protection: CoQ10, lipoic acid, ascorbyl palmitate, and gamma E.
The immune system is unlike other body systems in that it is not a group of physical structures but a system of complex interactions involving many different organs. White blood cells generate enormous amounts of destructive free radicals in order to kill invading organisms. Vitamin C, a free radical scavenger, is concentrated in these white blood cells at a much higher level than in surrounding fluid. This extends their life and effectiveness by providing them with a built in defense mechanism against their own free radicals. RENEWAL ANTIOXIDANTS provides water and fat-soluble vitamin C (ascorbyl palmitate and ascorbic acid) along with vitamin A, beta carotene, CoQ10, lipoic acid, quercetin, selenium, gamma vitamin E, tocotrienols, zinc and turmeric, for added immune defense.
Skin & Connective Tissue
Skin is rich in lipids, proteins, and DNA, which are extremely sensitive to oxidation. Age-related changes due to oxidation, loss of elastic fibers and thickening of collagen fibers, cause skin to become fragile and less supple. A broad array of antioxidants protects skin and helps maintain its structure and tone. These include beta carotene, vitamin C, vitamin E, grape seed, zinc, amla (Phylanthus emblica), quercetin, DMAE, manganese and myricetin. Amla is a very effective herbal tonic. It is rich in polyphenols and vitamin C.
Eye tissue is particularly prone to the effect of free radicals. Vision involves light being focused through the lens onto the retina. The macula, or center of the retina, receives the most light. However, sunlight is a powerful free radical generator. Lutein, a potent, fatsoluble antioxidant concentrated in the macula, helps maintain the integrity of the macula and the blood vessels that supply the macular region. The eye also has aqueous tissue that is better protected by water-soluble antioxidants, such as bilberry and grape seed. RENEWAL ANTIOXIDANTS provides these ingredients, along with lycopene, zeaxanthin, lipoic acid, vitamin A, beta carotene and ascorbyl palmitate to support healthy eyes.
Mitochondria, the tiny energy factories within the cells, are the major source of free radicals produced by our own bodies. These components of cells produce ATP (the energy molecule) and provide energy for all cellular activity; therefore, antioxidants are crucial to keep the levels of oxidants they produce in check. RENEWAL ANTIOXIDANTS provides the antioxidant power of green tea, lipoic acid, zinc, vitamin B-2, CoQ10 and Mega H-, a source of electron rich hydrogen ions. Coenzyme Q10 is fat-soluble and its primary functions include activity as an antioxidant and as a cofactor in many metabolic pathways, particularly in the production of ATP in oxidative respiration.
DNA, the blueprint for all molecules in the body, can be altered or damaged by oxidation. Protecting DNA is important for optimal health of all cells and tissues. According to invitro research, certain compounds, such as curcumin (from turmeric) and quercetin, can directly protect against strand-breakage and base oxidation. RENEWAL ANTIOXIDANTS contains these ingredients along with rosemary, pomegranate, raspberry, blueberry leaf, and carnosine. In in-vitro studies, L-CARNosine reduced glycation, a process in which DNA and protein are damaged by glucose.
Living Longer, Living Better Strategies for Wellness
Taking personal responsibility for your health and exploring safe alternatives to support prevention is the basis for the wellness revolution. Your health food outlet is leading the way with education and quality products to help you take control of your well-being. Source Naturals is pleased to partner with these outlets to bring you the cutting edge nutritional science of RENEWAL ANTIOXIDANTS. Antioxidant protection is a fundamental part of the holistic healing system. Make this profound formula the cornerstone of your anti-aging program today.
Clement, M., Bourre, J. Graded dietary levels of RRR-y-tocopherol induce a marked increase in the concentrations of a- and y-tocopherol in nervous tissues, heart, liver, and muscle of vitamin E-deficient rats. Biochimica et Biophysica Acta 1334 (1991) 173-181. Borgstrom, L. Pharmacokinetics of N-acetylcysteine in Man. Eur J Clin Pharmacol (1986) 31:217-222. Hipkiss, A.R., et al. Carnosine, a protective, antiaging peptide? Int J Biochem & Cell Biol. 30, May 1998, 863-868.
Heart and Blood Vessels Resveratrol, Gamma E, Tocotrienols, Vit C, Hawthorn Berry, Grapeseed, Myricetin, CoQ10, Ginkgo, Beta & Alpha Carotene, Zeaxanthin, Lycopene, Lutein, Astazanthin, Lipoic acid, Green Tea, Bilberry, Ginger, Turmeric, Blueberry Leaf
Brain and Nervous System DMAE, Ginkgo, Carnosine, Bilberry, CoQ10, Grapeseed, Lipoic Acid, Vit B-2, Lutein
Liver Lipoic Acid, N-Acetyl Cysteine, Vit A, B-2,and C, Beta Carotene, Silymarin, CoQ10, Selenium, Zinc, Gamma E, Tocotrienols, Turmeric, Ginger Glutathione, Wheat Sprouts
Immune System Vit A & C, Beta Carotene, CoQ10, Lipoic Acid, Quercetin, Selenium, Gamma E, Tocotrienols, Zinc, Turmeric
Skin & Connective Tissue Beta Carotene, Vit B-2, C & E, Grapeseed, Lutein, Lycopene, Zeaxanthin, Zinc, Amla, Quercetin, Manganese, DMAE
Eyes and Vision Lutein, Beta Carotene, Vit A & C, Bilberry, Lycopene, Zeaxanthin, Lipoic Acid, Quercetin, Gamma E, N-Acetyl Cysteine, Selenium, Zinc
Energy Production and Metabolism Green Tea, Ginger, Mega H-, Ginkgo, CoQ10, Lipoic Acid, Zinc, Vit B-2, Carnosine DNA Protection Turmeric, Quercetin, Rosemary, Grapeseed , Resveratrol, Lycopene, Lutein, Tocotrienols, GliSODin®, Carnosine, Zinc, Manganese, Amla, Pomegranate, Raspberry leaf, Blueberry leaf
Acetyl L-Carnitine & Alpha Lipoic Acid - For Cellular Vitality
June 24, 2005 05:24 PM
You may not think that your good health is related to the vitality of your cells, but it is. Your body is comprised of billions and billions of cells that work together in complex systems to keep you healthy.
But each of these cells also has a unique life. A primary role of your body is to keep these cells healthy and vital in every part of your body throughout your life. And to stay healthy, each of these self-contained cells must produce its own energy – cells can’t borrow energy from each other. Fortunately, there are steps you can take to maintain these cells that are so critical to your good health.
Source Naturals, the science company, introduces ACETYL L-CARNITINE & ALPHA LIPOIC ACID for your cellular vitality. It contains alpha lipoic acid and acetyl L-CARNitine, two compounds that can support your cellular vitality for your better overall health.
For Cellular Vitality
ACETYL L-CARNITINE & ALPHA LIPOIC ACID is a groundbreaking new combination of two amazing nutrients, alpha lipoic acid and acetyl L-CARNitine, that support your body’s own system for maintenance of cell function as you age.
Alpha Lipoic Acid for Vitality
Alpha lipoic acid is a fat and water soluble compound that is naturally found in your body. It directly recycles vitamin C and indirectly recycles vitamin E to help your body maintain beneficial levels of these important and protective antioxidants. Alpha-lipoic acid also supports the immune system and healthy liver function.
One of the most important roles alpha lipoic acid plays in your body is its role in cellular energy production. Alpha-lipoic acid is a coenzyme that assists in the conversion of pyruvate to acetyl-coA. Acetyl-coA is the beginning point for the Krebs cycle, one of the body's main energy production cycles, which produces the high-energy molecule ATP (adenosine triphosphate). By supporting the Krebs cycle, alpha lipoic acid supports your cellular vitality.
Acetyl L-CARNitine for Vitality
Acetyl L-CARNitine is a nutrient for your mind and your body. Medical experts believe that this form of carnitine, derived from an amino acid, is the most bioavailable form available. It supports your body’s synthesis of acetylcholine, a neurotransmitter that is critical for learning and memory. One of the most important functions that acetyl L-CARNitine performs in your body is its role in supporting cellular energy. This critical biochemical compound transports longchain fatty acids into the mitochondria in your cells. Cellular mitochondria are where these fatty acids are used to generate ATP, the metabolic energy for your cellular vitality.
Join the Wellness Revolution
Your life can seem to move at a dizzying pace. You might not have a lot of time to focus on your good health, and mainstream medicine doesn’t always incorporate the scientific advances of recent decades into their health recommendations for you. But you can benefit from new information right now by shopping for products like ACETYL L-CARNITINE& ALPHA LIPOIC ACID at your local health food stores and outlets, the only places where you will find these groundbreaking products to support your lifelong vitality.
Packer L et al. (1995). Alpha-Lipoic Acid as a Biological Antioxidant. Free Radical Biology and Medicine. 19(2): 227-250. Hagen T et al. (2002). Feeding acetyl-L-CARNitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. PNAS. 99(4): 1870-1875. Kern M et al. (2003) Effects of Acetyl-LCarnitine and Lipoic Acid supplementation on physiologic and psychological factors in older men. Med Sci Sports Exerc. 35(5S): 267.
Enhancer for Youthful Vitality
June 16, 2005 08:20 PM
NEW PRODUCT ANNOUNCEMENT
Enhancer for Youthful Vitality
Five tablets contain:
Suggested Use: 5 tablets before exercise and/or at bedtime with plenty of water at least two hours after the last meal. Discontinue use or reduce dosage if any of the following symptoms are present: nausea, excessive salivation, vomiting, diarrhea, muscle spasms, cramps, excessive urination, insomnia, headache, cardiac arrhythmias, high blood pressure, or changes in mood or emotional balance.
Thanks for the Memory
June 11, 2005 03:49 PM
Thanks for the Memory by Estelle Sobel , February 6, 2002
Thanks for the Memory By Estelle Sobel
"I feel like every day, I lose my memory more and more. It started when I couldn't find my car keys, sometimes I forget directions. My mother has Alzheimer's so I'm concerned," says Jerry Solowitz, a 63 year old man.
Ellen Lerner, 37, sometimes worries that she can't keep track of everything in her job as a public relations executive. "I feel like stress can get to me easily, and I worry because I forget simple things like where I put a file."
Should these people be concerned?
"Yes," says Lynda Toth, Ph.D., co-author with Pavel Yutsis, M.D., of Why Can't I Remember? Reversing Memory Loss (Avery, 1999).
Jerry should start a specific program with a health practitioner who specializes in memory loss, due to lots of unsuspected new causes for memory dysfunction. Ellen needs to make lifestyle changes, as stress can definitely lead to memory loss.
"Cortisol, which is one of the stress hormones, can be harmful because it keeps calcium in the memory pathway too long and destroys the neurons, which is very damaging to the brain," notes Toth.
Why Does Memory Fail?
Memory fails for several reasons, says Augustine DiGiovanna, M.D., author of Human Aging: Biological Perspectives, (McGraw-Hill 2000), and Professor of Biology at Salisbury State University in Salisbury, MD.
Normal Aging: Much of diminished memory as we age is due to reduced blood flow to the brain from atherosclerosis, which is hardening and narrowing of the arteries. Decreased blood flow causes neurons to shrink and function less effectively.
Also, as we age we lose neurons and neuron connections that can lead to memory loss. So the way people think, how much they remember, and the mental activities they do determine how many brain cells survive through the years.
Finally, as people live longer, the chance is greater that the body's immune system and other defense mechanisms won't be able to protect against certain diseases that affect the brain and memory (Parkinson's, strokes, Alzheimers, atherosclerosis).
A Starving Brain: The brain is not getting fed the nutrients it needs (vitamins, minerals, amino acids, glucose). Without the right "food" the brain's energy levels become lowered and stop powering the memory cells. Then, free radicals can do more dirty work and continue to rust memory cells.
Drink And Sink: Alcohol passes through the blood-brain barrier and slows down the processing of information between memory neurons. Memory loss increases over time, as memory tissues shrink.
Sad Stories: Depression can imbalance the neurotransmitters and electrical charges of neurons.
Tense and Tight: High blood pressure can constrict and narrow blood vessels, limiting blood and oxygen flow to the brain.
One way to boost brain power is to take the right supplements.
Ginkgo biloba: The powerful medicinal herb ginkgo biloba increases blood flow and circulation to the head by dilating blood vessels in the brain, allowing more oxygenated blood to get to the neurons. It also protects against free radical damage.
Research: Ginkgo biloba extract displayed a significant effect on helping the mental abilities of people 50-59 years old (Phytotherapy Research 13, 1999: 408-415).
Pregnenolone: This powerful hormone regulates the balance between excitation and inhibition in the nervous system and helps enhance memory and brain function, possibly by repairing a fatty substance that is part of the myelin sheath that surrounds nerve cells. Research: A St. Louis University School of Medicine study on mice showed that pregnenolone enhanced memory and helped mice to navigate mazes better.
Huperzine A: This herbal supplement is derived from club moss found in China; in purified form it inhibits the enzyme that breaks down acetylcholine, a neurotransmitter produced in the brain that you need for memory.
Research: Studies conducted by Alan Mazurek, M.D., found that huperzine A in purified form improves memory, enhances focus and concentration and has been used to improve memory loss in Alzheimer's patients (Alt. Ther. in Health Med. 5 , March 1999: 97-98).
Another study in The Journal of Neuroscience Research showed that huperzine A is a potent inhibitor of cholinesterase, which penetrates the brain and produces a dose-dependent increase of the neurotransmitters acetylcholine, norepinephrine and dopamine in rat cortex (41, 1995: 828-835).
Phosphatidylserine (PS): This substance, which occurs naturally in nerve cell membranes, helps keep fatty substances soluble and cell membranes fluid and helps reduce levels of cortisone which are damaging to tissues.
Research: Phosphatidylserine encourages a sense of calm by raising the levels of alpha brain waves and increasing the production of acetylcholine (Neuropsychobiology 24, 1990-1991: 42-48).
Vitamin E: This potent antioxidant attaches to bad cholesterol and helps prevent free radical damage to cells.
Research: Age-related processes like memory function and problem solving can be affected by free radical damage. Several studies show that vitamin E might slow the effects of Parkinson's disease and Alzheimer's disease (JAMA 282, August 18, 1999: 621). Acetyl-L-CARNitine: Increases cognitive performance because it rejuvenates cellular membranes of mitochondria, the storehouses of energy contained in every living cell.
Alpha-Lipoic Acid: Preserves memory tissue by increasing glutathione levels, which protect fat stores in neurons from being damaged.
Nine Ways to Remember
Dr. Lynda Toth suggests the following ways to make the most of what you've now got.
1) Power Up Your Smile. Remove dental fillings and replace them with porcelain or ceramic ones. The mercury in metal fillings may be harmful (some believe) and can affect the brain and nervous system, inflaming memory tissue and preventing the entry of nutrients into the cells.
2) Don't Be a Tin Man/Woman Avoid exposure to aluminum. Don't use aluminum pots to cook in. Aluminum accumulates in memory tissue, damaging cells. In fact, autopsies of Alzheimers patients show they have unusually huge amounts of aluminum in the brain. But no one knows where this aluminum comes from.
3) Eat Right. Eat organic and pesticide-free foods. Pesticides get into the cells and can damage DNA.
4) A Matter of Taste. Avoid foods with artificial coloring, monosodium glutamate (MSG, often called "natural flavors" or "natural seasoning"). Also avoid processed foods with taste enhancers called exito toxins such as l-cysteine and aspartic acid.
5) In the Raw. Make sure that your diet consists of enzyme-rich 50% raw foods (fruits and vegetables) to feed the brain. Eat less animal fats.
* Drink green juices to support levels of the brain's clean-up enzymes.
*Eat lots of fiber, which helps remove toxins from the body. Pick up psyllium fiber.
*Limit intake of processed sugar, caffeine and alcohol to lessen the load on the liver and pancreas.
6) Cut Bait. Watch the fish that you eat. Lots of ocean and inland-caught fish are contaminated with mercury. Go for deep, cold water fish such as cod. Avoid shark and swordfish.
7). Oil Up. Supplement your diet with omega-3 fatty acids, such as cod liver oil or flaxseed oil. These fats lubricate memory cells.
8) Work That Body. Stay fit and exercise. Exercise helps oxygenate the body, reduces cholesterol, and builds and energizes new memory cells which reduces wear and tear on the brain function.
9) Do Mind Games. Read, listen to music. Tune into different radio stations than the ones you normally listen to. Do crossword puzzles and a wide selection of word games which can stretch your brain and give it a tough workout.
Student of Life
You need to keep learning your whole life to keep your brain and memory in tip top shape. The brain is adaptable, and you are always building new neurons, says Dr. Toth, which means that there is no limit to how long it can develop. Anything that stimulates the brain will help it to grow. That's why as you get older it's even more important to take classes, start a new hobby, travel. In fact, the challenge of learning and doing new things (without stopping in a fit of frustration) causes your brain to grow, says Dr. Mazurek.
The Good News
As people get older, their brains may actually improve and repair themselves through a complicated process that is designed to eliminate faulty neurons that are prone to making mistakes. At the same time, brain activity goes on that results in the development of new and improved connections with neighboring neurons.
Research also shows that memory improves if you train people to have faith in themselves. (The brain helps those who help themselves.) Apparently, a confident perspective can encourage the brain to actually improve to the point where its new-found abilities may increase to the point where it fulfills expectations.
So keep your chin up and stay away from the artery-clogging saturated fat that can cut off the brain's blood supply. It's all in the attitude, says Dr. DiGiovanna. And, of course, the key to a long and happy life with your brain is also on the end of your fork and in that bottle of supplements.
Estelle Sobel, is the co-author of Beautiful Skin: Every Woman's Guide to Looking Her Best at Any Age (Adams Media, May 2000).
Mega Mind - re-align your body systems ...
June 03, 2005 05:24 PM
Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MEGAMIND™ is a Bio-Aligned Formula™ that helps align multiple systems: neurotransmitter production, antioxidant defense, energy generation, circulation, and myelin sheath generation. Complementary Formulations Source Naturals can help keep your mind sharp and alert. Use MENTAL EDGE® Bio-Aligned Formula for foundational support, or MEGAMIND, when memory symptoms* are severe. HIGHER MINDTM is an additional Bio-Aligned choice. Take these formulas alone or as the core of a program that includes additional ingredients such as DHA (NEUROMINS®), GINKGO-24™, PHOSPHATIDYL SERINE, VINCAMINE, and VINPOCETINE.
In today’s complex world, we are bombarded with information. Our ability to process this massive input depends on how well we nourish the multiple body systems related to brain health. In addition, normal aging is associated with impairment of certain mental functions, according to the National Institute on Aging. The brain undergoes changes including functional decline in neurons important to learning, memory, planning, and other complex mental activities, as well as increased oxidative stress. In healthy people, these changes may result in varying degrees of age-related memory decline. Source Naturals can help, with a full line of cognitive support products.
Mental Edge®: Bio-Aligned Formula
MENTAL EDGE is a literal multivitamin for your brain. MENTAL EDGE supports production of neurotransmitters including acetylcholine, antioxidant defense, energy generation, stress response and myelin sheath generation. It features nutrients needed for production of neurotransmitters— chemical messengers in the brain’s communication system. One of the most important of these is acetylcholine, which is necessary for memory and muscle movement. MENTAL EDGE also contains antioxidants—vitamin C, ginkgo, DMAE, and zinc—to protect the neuron cell membranes where electrical signaling takes place. Adaptogenic herbs provide the brain with support and energy to deal with environmental stress. Energy-generating ingredients such as ginkgo and B-vitamins are vital to the high-powered functioning of your brain. Vitamins B-5 and B-12 are also important for formation of myelin, a substance that forms a protective insulating cover around certain nerve fibers and increases nerve impulse conduction.
MegaMind™: Bio-Aligned Formula When memory symptoms* are severe, you may need a formula with extraordinary cognitive support. MEGAMIND addresses many of the same body systems as MENTAL EDGE, but does so with megadoses of brain nutrients, such as L-pyroglutamic acid and vitamin B-1 for neurotransmitter production. It also adds bacopa and the inhibitory neurotransmitter GABA to support neurotransmitter production, and higher potency vitamin B-12 for myelin sheath generation. Like MENTAL EDGE, MEGAMIND supports energy generation and antioxidant defense. MEGAMIND augments basic support for the brain’s immense energy requirements with higher potency vitamin B-1, and with one of nutritional science’s most advanced, high-tech nutrients, alpha-lipoic acid. Lipoic acid is also an antioxidant, as are gotu kola and grape seed. MEGAMIND also supports circulation with ginkgo and gotu kola.
Mega Mind: Bio-Aligned Formula HIGHER MIND is another multi-system support formula, which features phosphatidyl serine, a structural component of nerve cell membranes, and the botanical vinpocetine. HIGHER MIND nourishes neurotransmitter production, cell membrane stability, energy generation, antioxidant defense and myelin sheath generation.
Neurotransmitter Production: Bacopa, GABA, L-Glutamine, L-Pyroglutamic Acid, Taurine, N-Acetyl L-Tyrosine, Manganese, Vitamins B-1 & B-6
Acetylcholine Production: Acetyl L-CARNitine, DMAE, Gotu Kola, L-Pyroglutamic Acid, Vitamin B-5
Myelin Sheath Generation: Vitamins B-5 & B-12
Energy Metabolism: Acetyl L-CARNitine, Ginkgo Biloba, L-Glutamine, alpha-Lipoic Acid, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6 & B-12, Biotin,Folic Acid
Circulation: Ginkgo Biloba, Gotu Kola
Antioxidant Defense: DMAE, Ginkgo Biloba, Gotu Kola, Grape Seed, alpha-Lipoic Acid, Zinc, Vitamin C
Complementary Cognitive Support Products
For additional support, you can supplement Source Naturals Bio-Aligned formulas with these single ingredient products: ACETYL L-CARNITINE and DMAE are both important to the synthesis of acetylcholine, a key neurotransmitter associated with higher cognitive functions, such as learning and memory. DHA (NEUROMINS®) is an omega-3 fatty acid that plays a significant role in cerebral development, especially during fetal development and infancy. GINKGO is renowned for promoting blood flow to the brain. Source Naturals GINKGO-24™ is a standardized concentration of Ginkgo biloba leaves, yielding 24% ginkgo flavone glycosides and 6% terpenes (the key constituents). PHOSPHATIDYL SERINE is necessary for the health of nerve cell membranes, where electrical signaling takes place. These membranes are critical to information processing. VINCAMINE, an alkaloid obtained from the periwinkle plant, supports cerebral metabolism by promoting blood flow and oxygen and glucose utilization. VINPOCETINE is a derivative of vincamine, shown in research studies to improve cognitive performance and alleviate the short-term memory loss that may accompany stress or aging.
Lifestyle Tips for Cognitive Health: A Strategy for Wellness SM
Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a high-fat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Longterm anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities, through the use of memory aids such as “to-do” lists, notes, or calendars.