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Search Term: " Leaky "
The Secret to Gut Health: Feeding Your Microbiome for Maximum SCFAs   
Date:
September 11, 2026 01:29 PM
Your Complete Guide to Digestive Support: Building a Thriving Gut MicrobiomeWhen we talk about digestive health, the conversation usually stops at taking a daily probiotic or drinking enough water. But true microbiome health goes much deeper. It involves feeding the good bacteria you already have, ensuring your body can properly break down fats, and timing your supplements right.If you want to optimize your digestion, you need to understand how different fibers work, the magic of "postbiotics," and how specialized enzymes keep everything running smoothly. The Magic of Short-Chain Fatty Acids (SCFAs)To understand gut health, you have to understand a process called fermentation. When you eat dietary fiber that your stomach can't digest, it travels down into your colon. There, your gut bacteria feast on it.When these good bacteria eat fiber, they release beneficial byproducts called Short-Chain Fatty Acids (SCFAs) - most notably butyrate, acetate, and propionate. Think of SCFAs as the ultimate super-fuel for your digestive system. They provide the main energy source for the cells lining your colon, helping to keep the gut barrier strong and preventing "Leaky gut." SCFAs also help calm inflammation throughout the body and play a massive role in healthy metabolism. But to get these benefits, you have to feed your microbiome the right type of fibers. The Ultimate SCFA-Boosting TrioNot all fibers are created equal. Some just add bulk to your stool, while others are "prebiotics" - meaning they actively feed your good bacteria. To maximize SCFA production, combining different types of prebiotic fibers is incredibly effective.Here is a functional combination that acts as a powerhouse for your microbiome:
Glucomannan vs. Psyllium: Which Fiber is Right for You?If you are looking to supplement with an isolated fiber for digestive support, you will likely encounter two heavyweight contenders: Glucomannan and Psyllium. Both are soluble fibers, meaning they dissolve in water to form a gel in your stomach, but they act a bit differently.
Can You Take Fiber With Vitamins?A very common question is whether you can take your daily fiber supplement alongside your morning vitamins.The short answer is no. You should separate them. Because soluble fibers (like psyllium, glucomannan, and even high doses of acacia) form a thick, sticky gel in your digestive tract, they act like a sponge. If you take them at the exact same time as your daily vitamins or minerals, the fiber can bind to the nutrients. Instead of absorbing those vitamins into your bloodstream, your body will simply sweep them out in your next bowel movement. The Golden Rule: Take your vitamin and mineral supplements at least 1 hour before or 2 hours after taking a heavy fiber supplement. Beyond Fiber: The Benefits of Ox Bile for Fat DigestionFiber takes care of the carbohydrates, but what about the fats? Many people eat a healthy diet but still experience bloating, indigestion, or floating stools after a rich meal. This is often an issue with bile.Bile is a fluid produced by your liver and stored in your gallbladder. When you eat fats, your gallbladder squirts bile into your intestines. Think of bile like dish soap on a greasy frying pan—it emulsifies the fat, breaking it down into tiny droplets so your body can absorb it. If you have had your gallbladder removed, or if your liver is simply sluggish, your body might not release enough bile. This means fats pass through your system undigested, missing out on crucial fat-soluble vitamins (like Vitamins A, D, E, and K). This is where ox bile comes in. Taken as a supplement with meals, ox bile closely mimics human bile. The benefits include:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6652) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally Leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Unlocking Your Cellular Vitality: Understanding the Role of Mitochondria in Energy and Aging
Date:
September 09, 2026 05:22 PM
Introduction: Understanding Cellular Aging and Energy DeclineHave you ever wondered why you could bounce back from an all-nighter or an intense workout in your twenties, but in your forties or fifties, the same physical effort leaves you feeling drained for days?Most people think aging is something that happens strictly on the outside - fine lines around the eyes, stiff joints, or gray hairs. In reality, aging begins at a microscopic scale inside your cells, the microscopic building blocks that make up every tissue, muscle, and organ in your body. Every single day, your body relies on roughly 30 trillion cells working in unison. When your cells are young and resilient, they operate like a well-oiled machine: they repair minor damage instantly, clear away waste, and produce abundant energy. But over time, two fundamental biological shifts take place:
The Role of Mitochondria and ATP ProductionTo understand where your daily energy comes from, you have to look inside your cells at tiny structures called mitochondria.Often called the "powerhouses" of the cell, mitochondria function like miniature power stations. A single cell can house hundreds or even thousands of them, especially energy-hungry cells like those in your heart, brain, and skeletal muscles. The Body’s Energy Currency: What is ATP?Your body cannot directly use a sandwich or a cup of coffee to power muscle contractions or brain signals. Instead, your mitochondria take the nutrients from your food and combine them with the oxygen you breathe to manufacture a chemical molecule called adenosine triphosphate (ATP).Think of ATP as your body’s universal energy currency:
Why Cellular Energy Production Declines with AgeWhen you are young, your mitochondria are abundant, pristine, and remarkably efficient. However, the very process of creating energy comes with an unavoidable side effect: oxidative stress.Much like an engine produces exhaust fumes while burning fuel, mitochondria produce reactive byproducts known as free radicals (reactive oxygen species). Over decades, these "exhaust fumes" slowly damage the inner machinery of the mitochondria:
How Cellular Senescence Accelerates the Aging ProcessIf mitochondrial decline is a problem of power shortage, cellular senescence is a problem of biological clutter and pollution.In a healthy body, normal cells follow a strict lifecycle: they divide, perform their jobs, and when they incur significant damage or reach the end of their useful lifespan, they undergo a tidy self-destruction process called apoptosis (programmed cell death). Your immune system then clears away the debris, making room for fresh, vibrant cells. Cellular senescence happens when this cleanup process fails. The "Zombie Cell" PhenomenonWhen a cell experiences extreme stress - such as shortened telomeres (the protective caps on chromosomes), severe DNA breaks, or severe mitochondrial dysfunction - it reaches a biological crossroads. To prevent the damaged cell from dividing uncontrollably (which could lead to tumors), the body puts the brakes on.The cell enters a permanent state of dormancy:
Why Zombie Cells Are So Damaging: The Bad Apple EffectHaving a few retired cells hanging around might not sound catastrophic, but senescent cells do not sit quietly. Instead, they secrete a toxic chemical cocktail known as the Senescence-Associated Secretory Phenotype (SASP).This cocktail is packed with pro-inflammatory cytokines, chemokines, and tissue-degrading enzymes. Picture one spoiled apple sitting in a fruit basket: the ethylene gas it emits quickly causes the healthy apples surrounding it to rot. In the same way, the toxic secretions from zombie cells:
The Vicious Cycle of Cellular AgingMitochondrial decay and cellular senescence are not isolated events; they feed directly into one another:
What This Means for Everyday HealthThe good news from modern longevity science is that cellular decline is not entirely out of our hands. While aging is natural, the rate at which our cellular engines degrade can be influenced by daily habits:
Summary: Aging is fundamentally a microscopic process occurring inside the body's trillions of cells, which naturally become less resilient over time. Central to this decline are the mitochondria, the tiny structures that function as the cell's "power plants" to produce adenosine triphosphate (ATP), the universal chemical currency for everyday energy. While young mitochondria are abundant and pristine, decades of producing ATP generate oxidative stress through byproducts called free radicals, which eventually wear down and damage mitochondrial DNA and machinery. This damage results in fewer, less efficient power generators, lowering total cellular energy output, which individuals experience as real-world physical fatigue and mental fog. Aging is further accelerated by cellular senescence, a condition where damaged cells stop dividing but, instead of naturally self-destructing like healthy ones, linger behind as dormant "zombie cells." These senescent cells secrete a pro-inflammatory chemical mixture known as the Senescence-Associated Secretory Phenotype (SASP), which functions like a "bad apple" by poisoning healthy neighboring cells and tissues, creating a state of chronic biological pollution termed "inflammaging." Mitochondrial decay and senescence feed into one another in a vicious cycle that directly drives overall aging. However, longevity science highlights that healthy lifestyle habits, including regular exercise and periods of fasting, can support continued vitality by encouraging the development of new mitochondria and the clearing of this toxic cellular clutter.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6649) Leaky Gut vs. The Postbiotic Fortress: Strengthening Your Microbiome Shield
Date:
February 20, 2026 01:50 PM
The "Postbiotic" Revolution: Why Your Gut’s Waste is Its Best AssetFor years, the conversation around gut health was a two-player game. You had Prebiotics (the fiber-rich "fuel") and Probiotics (the "live bacteria"). But in 2025 and 2026, the scientific community has pivoted to the third and most important piece of the puzzle: Postbiotics.While we’ve long obsessed over the "tenants" living in our gut, we are finally realizing that it’s their work - specifically the chemical metabolites they produce - that actually runs the show. Postbiotics, particularly Short-Chain Fatty Acids (SCFAs) like Butyrate, Propionate, and Acetate, are the actual "workers" that translate bacterial activity into human health. The Big Three: Acetate, Propionate, and ButyrateWhen you eat a high-fiber meal, your microbiome ferments those fibers into SCFAs. These aren't just waste products; they are high-powered signaling molecules that act like a Wi-Fi signal between your gut and the rest of your body.
Feeding the Gut from the Inside OutMost cells in your body get their energy from the bloodstream. Your colonocytes (the cells lining your large intestine) are different. They are the only cells in the human body that prefer to eat "locally."Butyrate serves as the primary fuel source for these cells, providing up to 70% of their total energy requirements. Research from late 2025 emphasizes that without adequate butyrate, colon cells undergo a form of "cellular starvation," leading to a breakdown in the gut barrier—often referred to as "Leaky gut." By "feeding" these cells from the inside, butyrate ensures the intestinal wall remains a tight, fortress-like seal against toxins. 2025/2026 Research: The Signaling RevolutionThe most exciting shift in recent research (2025-2026) is the discovery of how these metabolites act as "systemic messengers." They don't just stay in the gut; they enter the bloodstream and talk to your most vital systems:
Why Postbiotics are the FutureThe beauty of postbiotics lies in their stability. Unlike probiotics, which can die on the shelf or in your stomach acid, postbiotics are heat-stable and have a predictable impact.We are moving away from the "spray and pray" method of taking random bacteria and toward a precision model: delivering the specific metabolites your body needs to thrive. The "Postbiotic" Revolution marks a pivotal shift in gut health, moving beyond live bacteria to focus on the powerful metabolites they produce, specifically Short-Chain Fatty Acids (SCFAs) like Acetate, Propionate, and Butyrate. While 2025/2026 research highlights how these molecules act as systemic messengers - regulating neuroinflammation in the brain and triggering natural satiety hormones like GLP-1 - the most critical scientific breakthrough remains the role of Butyrate as the primary energy source for colon cells. By fueling colonocytes from the inside out, these postbiotics maintain the integrity of the gut barrier and serve as the "actual workers" that translate microbial activity into tangible improvements for the immune system and metabolism.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6631) Benefits of butyrate and other SCFAs which are produced by the friendly bacteria in the gut!
Date:
November 15, 2025 11:14 AM
Of course. The short-chain fatty acids (SCFAs) produced by your gut bacteria are powerful metabolites with wide-ranging, systemic benefits. While there are three main SCFAs - Butyrate, Acetate, and Propionate - each has slightly different functions. Butyrate, in particular, is a superstar for gut health. Here is a list of their most important benefits, categorized by body system. 1. Gut Health & Integrity (The Primary Benefit)This is where SCFAs do their most direct and important work.
2. Immune System RegulationYour gut houses over 70% of your immune system, and SCFAs are the main molecules that "talk" to it.
3. Brain Health (The Gut-Brain Axis)SCFAs are a critical communication link between your gut and your brain.
4. Metabolic HealthSCFAs play a major role in regulating your metabolism, energy balance, and blood sugar.
5. Cardiovascular & Liver Health
At-a-Glance: The "Jobs" of Each SCFA
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6628) Can Akkermansia Muciniphila help the body fight leaky gut?
Date:
November 05, 2025 11:58 AM
Yes, based on a significant body of research, Akkermansia muciniphila is strongly associated with helping the body combat "Leaky gut" by strengthening the intestinal barrier. "Leaky gut" is the common term for a medical condition known as increased intestinal permeability. This happens when the lining of your gut is damaged, allowing bacteria, toxins, and undigested food particles to "leak" from your intestines into your bloodstream, which can trigger inflammation and other health issues. Akkermansia muciniphila (or A. muciniphila) is a beneficial bacterium that lives in the mucus layer of your intestines. It plays a direct and crucial role in keeping this gut barrier strong and healthy. How Akkermansia Helps Fight Leaky GutHere are the primary ways A. muciniphila works to protect your gut lining:
The Bigger PictureResearch consistently shows that lower levels of A. muciniphila are linked to a weakened gut barrier and conditions associated with Leaky gut, including:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6624) The Benefits of L-Glutamine for Your Health and Wellness
Date:
December 07, 2022 02:58 PM
If you’re looking to take your health and wellness journey to the next level, it’s time to consider adding L-Glutamine into your daily routine. This supplement has been proven to support lean muscle growth, assist in recovery from workouts, promote healthy immune function, and provide digestive support. Let's explore why this supplement can be beneficial for overall health and wellness. What is L-Glutamine? L-Glutamine is an amino acid that plays a vital role in cellular health by providing nitrogen for cell production. It is found naturally in the body, but efforts such as intense exercise, stress, injury or illness can cause a decrease in its levels. Supplementing with L-glutamine can help keep levels consistent in order to reap the full benefits of this nutrient. Benefits of L-Glutamine L-glutamine provides several benefits for those looking to improve their wellness journey. For starters, it helps build lean muscle mass by helping the body metabolize protein more efficiently. Glutamine is one of the most abundant amino acids found in muscle. Additionally, taking this supplement can help reduce post workout fatigue and enhance overall recovery time after a strenuous workout session. Furthermore, due to its antioxidant properties, it may also aid in immune system functioning by protecting against free radical damage caused by inflammation and stress. Finally, glutamine plays an important role in maintaining proper digestion by providing fuel for cells that line the small intestine which supports nutrient absorption.* Glutamine may even help reduce Leaky gut syndrome.* Incorporating Glutamine Into Your Diet The good news is that there are plenty of ways you can incorporate l-glutamine into your diet without having to resort to supplements or shakes. Some food sources include red meat, fish, dairy products like yogurt or kefir, eggs and legumes such as beans or peas.* It’s also easy enough to find l-glutamine powder which can be added into smoothies or healthy snacks like energy bars.* So, if you're looking for an effective way to take your health and wellness journey to the next level with natural methods rather than synthetic ones - then incorporating l-glutamine into your diet could be the answer! This supplement has been known to support lean muscle growth while aiding recovery from workouts and promoting healthy immune system functioning along with digestive health - making it a great addition to any lifestyle! Be sure to consult with your healthcare provider before starting any supplementation regime though!*
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6571) Natural antifungal remedies that reduce candida overgrowth
Date:
March 18, 2019 05:11 PM
Did you know that the most common cause of yeast infections in humans is caused by a fungi called Candida albicans? Those who have a high presence of Candida albicans can experience symptoms such as brain fog, depression, and unstable moods. Researchers have found that there are several natural remedies that can help decrease the presence of Candida albicans within our systems. Substances such as coconut oil have natural antifungal properties which help fight off any overgrowth of Candida albicans. Key Takeaways:
"If you suffer from candida overgrowth, you may experience symptoms like mood swings, leaky gut, brain fog, and depression, which can interfere with your daily life." Read more: https://www.naturalnews.com/2019-01-05-natural-antifungal-remedies-that-reduce-candida-overgrowth.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6080) 7 benefits of glutamine
Date:
January 08, 2019 08:13 AM
Glutamine is just one of several free amino acids that are naturally present within the human body, but glutamine just happens to serve a plethora of benefits that most of us aren't even aware of. Glutamine has the ability to improve cognitive function through helping the production of gamma-aminobutyric acid within the brain. It can also boost our immune systems by building the gastrointestinal wall, which could be due to 70% of glutamine being found in the gut. Key Takeaways:
"Cancer treatments like radiation and chemotherapy are very intense processes that have repercussions on a person’s health. Studies have shown that taking glutamine effectively reduces the complications that therapy has on metabolism while still preventing tumor growth." Read more: https://www.naturalnews.com/2019-01-04-7-benefits-of-glutamine.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5941) Oil Of Oregano & 6 Other Health Supplements That Can Help TreatDigestive Issues
Date:
September 01, 2018 05:53 PM
In today's world, there are so many different options of foods and brands that claim to be healthier than the next. There are many supplements that people take and they all have different reasons for it. Now, the age of the bodybuilder has really increased and people are trying to achieve a certain look. Oil of oregano and other health supplements are more for the issues that involve being able to digest things more efficiently and safely. Key Takeaways:
"Leaky gut is the cause for many malabsorption issues, which means even if you are eating a healthy diet and taking care of yourself your body may not be absorbing these nourishing nutrients." Read more: https://sporteluxe.com/oil-of-oregano-6-other-supplements-that-can-help-treat-your-digestive-issues/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5738) Hydrochloric Acid: The Stomach Acid that Defends Against GERD, Candida & Leaky Gut
Date:
August 20, 2018 09:53 AM
Hydrochloric Acid is a key digestive juice which tends to decrease within your body as you get older, causing a variety of digestive and non-digestive issues. Less hydrochloric acid means a less acidic gut, which can result in higher incidence of heartburn, gas, acid reflux, bacterial or yeast infections and other conditions. While some decrease in hydrochloric acid is a common part of aging, eating too much processed food, not exercising and other lifestyle issues can exacerbate it. Key Takeaways:
"Additionally, not producing enough HCL can lead to many other problems, such as skin problems, including acne or rosacea, mineral deficiencies and autoimmune reactions." Read more: https://draxe.com/hydrochloric-acid/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5715) Colostrum may provide relief for leaky gut sufferers
Date:
March 26, 2018 09:17 AM
When it comes to one's physical well being and overall health, perhaps one of the most important aspects that ties everything together is that of a proper functioning digestive system to be able to handle the food that is being eaten and absorb the nutrients. For those suffering from the ailment known as leaky gut, this can be difficult. However, recent studies have emerged claiming that drinking colostrum can be widely beneficial in helping alleviate some of the side effects of it. Key Takeaways:
"If you’re suffering from leaky gut syndrome, consider drinking some colostrum, which can help protect your intestinal tract." Read more: https://www.naturalnews.com/2018-03-21-colostrum-may-provide-relief-for-leaky-gut-sufferers.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5563) Inflammation 101 – get smart for good health
Date:
October 18, 2017 01:14 PM
First starting off giving a complete discription explaining what inflammation really is. The parts of the body it effects, and some things that can prevoke a reaction. Stating new information to help supside the pain helping live a normal life. After giving a personal Outlook on clean food, she provides a list showing inflammatory foods and other everyday items that we consume to try to avoid and a better alternative suggestions for someone who has inflammation. Key Takeaways:
"It is no longer appropriate to allow our dietary habits to contribute to the morbidity and mortality of the majority of humans." Read more: http://www.dorchesterbanner.com/health-and-fitness/inflammation-101-get-smart-good-health/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5349) 5 Reasons Your Leaky Gut Isn't Healing—and How to Overcome Them
Date:
October 07, 2017 10:14 AM
Your leaky gut may not be healing. This is bad news. You won't feel better until it heals. There can be other health problems caused by it as well. This gives five reasons for the lack of healing so you know what to watch for. This will help you so you can make sure things change. If you know what's wrong you can enact changes to make it better. You can't do this if you're clueless. Key Takeaways:
"While you’ve probably heard of “leaky gut,” few people realize that it a serious medical condition that occurs when the gut lining becomes permeable, causing the normally tiny gateway openings between the intestines and bloodstream to enlarge." Read more: http://observer.com/2017/09/reasons-your-leaky-gut-isnt-healing-and-how-to-overcome-them/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5316) New hope for leaky gut sufferers: Spore-based probiotics found to improve gastrointestinal health
Date:
September 26, 2017 09:14 AM
There is new hope for people that suffer from a leaky gut. Probiotics that are spore based have been found to improve gastrointestinal health. They are the answer to leaky gut syndrome. The researchers came to this conclusion thanks to study they did. Leaky gut syndrome can lead to things like fatigue and inflammatory skin diseases as well as food sensitivities. It is very important for people that are suffering from this to get help right away. Key Takeaways:
"According to the results of the experiment, the probiotic brought about a 42 percent decrease in endotoxin levels, a 24 percent decrease in triglyceride levels, while endotoxin levels rose by 36 percent in the placebo group and triglycerides fell by five percent." Read more: http://www.naturalnews.com/2017-09-17-new-hope-for-leaky-gut-sufferers-spore-based-probiotics-found-to-improve-gastrointestinal-health.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5280) Is Your Digestive System On Fire?
Date:
July 15, 2017 07:14 PM
Many people have health problems that can be related to issues with the gut. One lady had issues with weight gain and feeling tired, it turned out that she had many food allergies and a leaky gut. She needed to help the leaky gut or she would continue having issues with absorbing nutrients. Many people take a lot of medications like antibiotics, which cause harm to the gut. Many people also have a low level of B12 because of the gut not absorbing it . Read more: Is Your Digestive System On Fire?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4979) 7 Reasons Your Gut Wants A Probiotic, Stat
Date:
June 15, 2017 07:14 PM
Having a healthy microbome keeps you healthy and promotes longevity. Taking probiotics is the first step in maintaining a healthy gut. When you are on probiotics you will notice positive changes. You mood will be elevated, your immune system gets stronger and you will become less constipated. You can prevent a leaky gut and have a good balance of gut bacteria while preventing fungus infections. You also get an added bonus of healthy glowing skin. Read more: 7 Reasons Your Gut Wants A Probiotic, Stat
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4839) Colostrum: Immune Boosting Powerhouse
Date:
May 25, 2017 04:14 PM
Colostrum is a great natural supplement that can help people with leaky gut issues and offers great anti-oxidant and immune boosting properties. Colostrum is naturally found in mammals milk shortly after they give birth so babies are already exposed to it when they are first born. They are vital in children but they can also benefit adults who are tolerant to a dairy lifestyle. For an adult, it is like an extra boost that can help heal and mend the body. Key Takeaways:
"In a very simple sense, Colostrum is like an extra dose of immune system that you can leverage to help heal and strengthen your body." Read more: https://www.organicnewsroom.com/colostrum/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4693) 5 Foods To Support Digestive Health
Date:
May 05, 2017 11:44 AM
It is extremely important to use good grammar when you speak and also when you write. If you don't others will write you off as under educated or unprofessional. If you write for any career you'll see grammar mistakes causing you problems if they're allowed to stand. Getting your grammar corrected can help avoid these problems. If a human corrects your grammar you can be sure they checked it and didn't see mistakes. Humans aren't perfect, though, so of course an error can be made. Key Takeaways:
"For anyone who experiences poor digestive health, they understand that an unhappy gut can lead to a plethora of other issues, with discomfort and pain only a small part of the problems associated with digestive illness. Good gut health can address many symptoms, underlying causes and inflammatory processes of illness. Improving digestion also reduces reactivity to foods that can impact health and wellbeing." Read more: http://www.mindfood.com/latch/au/article/5-foods-to-support-digestive-health/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4541) This Homemade Colon Cleanse Juice Will Flush Toxins From Your Body
Date:
March 14, 2017 11:14 AM
There is a homemade colon cleanse juice that will flush toxins from your body. Many people have issues with their colon and would benefit greatly from a cleanse. The good thing to realize is that you can make the right cleanse right at your home. There will be changes to your body as you begin the cleansing process. https://www.youtube.com/watch?v=9gW_69RHlFYKey Takeaways:
"Because the colon has the important job of eliminating waste, it's critical you keep it running smoothly."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4144) 8 Signs That You Have A Leaky Gut And How To Fix It
Date:
December 06, 2016 02:59 PM
Do you have a Leaky gut? It is a potentially dangerous condition that could cause a whole host of problems that you'd never guess had anything to do with intestinal health, from chronic fatigue and headaches to skin problems and joint pain. A healthy, happy gut is a key part of your overall health, and you can take some simple steps to ensure it stays in top shape. Key Takeaways:
"Leaky gut syndrome is just as it sounds. It’s an abnormal increase in the permeability of your small intestine." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3584) Larch Extract
Date:
October 09, 2012 04:39 PM
Larch Tree Over the years, researchers and scientists found out the larch tree extract proved to the answer to all problems that people is facing. People's bodies are prone to illnesses and sickness and no matter they do it is not enough. The main reason why people get ill easily is that their immune system is not stable and always decreases from time to time. As a result, people's immune system will increase over the years, and it is always depending on the person. What is a larch tree extract? A larch tree extract is a natural polysaccharide extracted from larch tree. This sugar contains active ingredients that enhance the functions of all immune systems, tissues, and cells. This extract also called as arabinogalactan a biopolymer that consists of sugars, which attached to any protein food that helps your body to withstand and eliminates free radicals in your body. These active ingredients are the main responsible for increasing your metabolism that eliminate, and reduce free radicals. Even, your body does not yet increase its immune system, but this extract will surely do extensive favor that protects your body's vulnerability. Having an illness or an ailment due to a low immune system is difficult to handle because it always affects everything like your work performances, relationships, and even, your focus. Therefore, it is indispensable to prevent this from happening at all cost! Why use a larch tree extract? There are many benefits you can get using larch tree extract and these are as follows: 1) Boosts and increase your immune systems - this extract can help fights free radicals in your body that giving you diseases and sickness such as influenza, flu, and the common cold. It is also the best treatment for inflammation, rheumatism, asthma, bronchitis, and diarrhea. This extract also fights recurrent immune problems such as viral infection, and chronic fatigue. 2) Treatment for cancer - this extract can help fight cancer cells that normally triggered by decreasing the activities of NK cells. This extract will suppress and reduces these cancerous cells to nothing. In addition, it prevents these NK cells from spreading to any other organs. Larch extract also serves as an excellent foundation of fiber that potentially improves colon health by increasing the growth of its healthy bacteria located in the gastrointestinal tract. 3) Supports digestion - this extract acts as a food supply to your intestinal bacteria, so they are eating it instead of food nutrients and considering as a prebiotic that is stimulating the activity or growth of bacteria in your digestive systems considered as health beneficial. Prebiotics helps to treat and prevent intestinal conditions such as irritable bowel syndrome, LBM, constipation, Leaky - gut, and diverticulosis. In addition, prebiotics are the best treatment for ulcerative colitis and Crohn enteritis. Is there any need to take larch tree extract? If you want to stay as healthy as a cow, taking this extract is the best solution! Increasing your immune systems is your main goal to remain healthy over the years and it is easy. Remember that prevention will always better than cure!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2683) Chronic fatigue syndrom and your life styles
Date:
September 01, 2010 07:55 PM
Fight Chronic Fatigue SyndromChronic fatigue syndrome strikes more than two million people in the United States, with eighty-five percent of these people being women between the ages of thirty and fifty. The symptoms of chronic fatigue syndrome often resemble many other viral infections, making it very hard to pinpoint the real problem. This condition is possibly caused by stress as well as by mercury poisoning from amalgam fillings, hypoglycemia, anemia, hypothyroidism, sleep apnea, food and chemical allergies, weak adrenal function, parasitic infections, amino acid deficiencies, and Candida albicans infections. With all of this in mind, there are a couple of herbal combinations and healthful suggestions that can be followed to help prevent or deal with chronic fatigue syndrome.Cordyceps sinensis is a natural Chinese supplement that contains high amounts of L-tryptophan. It provides nutrients that are necessary for relieving fatigue and improving endurance. It also helps to increase blood supply to the heart and brain. This herb increases the production of superoxide dismutase in the body. In China, this herb has been traditionally used to treat the nervous system. Additionally, it is used to help strengthen the kidneys and liver. An herbal combination containing bee pollen, licorice, kelp, barley grass, schizandra, gotu kola, eleuthero, yellow dock, rose hips, and capsicum has been shown to help restore energy to the system. This combination is an excellent combination of herbs to feed and nourish the entire system. It provides nourishment for the adrenals, in the form of licorice, and also for the thyroid, in the form of kelp. The bee pollen in this combination helps to nourish and supply energy to the body. Barley grass nourishes and cleans the body, while schizandra, which is an adaptogen herb, increases the energy supply of cells in the brain, muscles, liver, kidneys, glands, nerves, and in the entire body. The combination of herbs will rebuild the blood, liver, and digestive system.
The following are a few suggestions that can be followed to help deal with and prevent chronic fatigue syndrome. Exercise is very helpful, with even mild exercise helping to increase stamina and oxygenate cells. Exercise also helps to improve sleep. Allergies can be involved in chronic fatigue syndrome, so it is important to look into food allergies, chemicals, and heavy metals, and eliminate them. Anytime there is inflammation in the body that is accompanied by pain, swelling, heat, and redness, allergies are likely the culprits. When the immune system is weak, candida is usually involved.
Candida and Chronic Fatigue SyndromA candida diet would help to restore natural flora to the system. Candida can prevent the body from using sugars properly, which blocks the body’s energy production and causes extreme fatigue. To restore the friendly bacteria, use acidophilus on an empty stomach and eat unsweetened yogurt. If candida is involved, it is important to eliminate sugar, alcohol, mushrooms and all fungi, molds, and yeast in any form. It is also important to eliminate fermented foods. Look into Leaky gut syndrome, which typically allows germs, viruses, bacteria, worms, and parasites to flourish. When they flourish, the immune and nervous system become weak, causing diseases such as chronic fatigue syndrome to weaken the body. Trying natural remedies like Fatigue to fantastic herbal supplements may help ease chronic fatigue.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2181) Support Good Stomach Health and More With DGL Licorice
Date:
August 14, 2010 10:48 AM
What is DGL LicoriceWe all know what licorice is - the root of the licorice plant, or Glycyrrhiza glabra - but what is DGL licorice? In fact it is licorice with a substance known as glycyrrhizin removed. This substance is dangerous to your health because it can cause hypertension and also reduce potassium levels. By removing this, those suffering high blood pressure can also take advantage of its health benefits. So what are these benefits?
They are not wide-ranging, but they are very important to you if you suffer any of a range of gastric problems, such as ulcers and gastritis. It can also be used to treat irritable bowel syndrome (IBS), Leaky gut syndrome, and Crohn's disease, and can also be used in autoimmune conditions such as rheumatoid arthritis and lupus. If you suffer any of these conditions it worth trying DGL licorice, but let your physician know what you are doing. Give DGL Licorice a try and see how it can help you!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2178) Bilberry
Date:
August 30, 2008 09:43 AM
Bilberry is a part of the herb world that has recently begun re-emerging because of recent scientific discoveries linking the fruit to therapeutic properties in blood vessel-related disorders. If you happen to suffer from any disorder that is related to weaken blood vessels, then you should definitely think about bilberry as part of your treatment, as it can be safe and extremely effective. Bilberry is a rich source of anthocyanidins, which gives it the unique ability to stabilize and protect collagen stores. This helps to prevent capillary leakage and hemorrhage. Bilberry is currently being used to treat vascular and blood disorders, and is also a main ingredient in the treatment of many visual problems. It has even been proven effective for varicose veins, thrombosis, diabetes, macular degeneration, and angina. Thanks to its rich amounts of anthocyanosides, bilberry is an extremely valuable treatment for a variety of disorders in which Leaky veins cause tissue damage. Containing over 15 different anthocyanosides, bilberry protects the veins and arteries, as it boosts a great deal of physiological processes that results in the improved integrity of capillary walls. Additionally, anthocyanosides prevent platelets from sticking to the walls of vessels, which helps to prevent the formation of blood clots. Bilberry has shown healing properties including: analgesic, anti-arthritic, anti-clotting, antiulcer, anti-edemic, anti-inflammatory, anti-osteotic, cyclooxygenase inhibitor, inhibits collagenase, inhibits elastase, lipoxygena, smooth muscle relaxant, lowers blood sugar, and vasodilator. With more than 100 names from around the world, bilberry also can be known by: huckleberry, whortleberry, European blueberry, myrtle bilberry, myrtle blueberry, myrtle whortleberry, Rocky Mountain whortleberry, red whortleberry, black grouseberry, low bilberry, mountain blueberry, huckleberry, and blueberry. Bilberry is a perennial shrub that can be commonly found in many different climates around the world that are characterized by damp woodlands and moorlands in northern Europe, northern regions of America, and parts of Canada. Bilberry grows as a small shrub with wiry, angular branches that do not usually grow over a foot high. The branches of bilberry bear waxy flowers and black berries that are covered with a grey bloom when they are ripe. The leather-like leaves of bilberry are initially rose color, but turn to a yellowish-green in the summer and a fiery red in the autumn. Growing abundantly in areas of England and flourishing best on high ground in the north and west regions of Britain, bilberry possesses a round fruit or berry that has a flat top and is approximately the size of a black currant, with a taste that is slightly acidic. The berry bushes prefer filtered shade and moist, fertile soil that is acidic and non calcareous. The bilberry plant is related most closely to blueberries and currants, all of which belong to the genus Vaccinium. Bilberries are rich in carbohydrates, tannin, vitamin A, and vitamin C. It also contains glucoquinine, which is able to lower blood sugar.
Finally, bilberry is considered an astringent; it exhibits antibacterial properties in the intestines. Bilberry’s analgesic properties are often thought to come from chlorogenic-acid and ferulic-acid content. Bilberry contains copper, quercetin, linoleic-acid, magnesium, pantothenic acid, ursolic acid, and zinc. This herb is good for the parts of the body that contain small fragile blood vessels such as the eyes and this is why this herb is associated with promoting eye health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1878) Una de Gato (Cat’s Claw)
Date:
April 26, 2008 09:36 AM
Una de Gato, otherwise known as cat’s claw, is properly Unicaria tomentosa. It has been used as an herbal medicine for at least two thousand years by the people of Central and South America who gave it the name vilcacora. It grows in jungle areas and rainforest in South America and Asia, and gets its name from the small claw-like thorns at the base of the leaves. One of the environmental benefits of the Una de Gato is that when it is harvested at three feet above the ground, it grows back to its full size of up to 100 feet within a few years when it can be harvested again to three feet. Cat’s claw has been given dietary supplement status by the FDA. The Peruvian Asháninka tribe has used the plant as a contraceptive and for the treatment of rheumatic conditions, diabetes, acne, diarrhea, cancer, urinary tract diseases and as an anti-inflammatory, and many of the studies of cat’s claw have centered on this tribe. The studies quickly showed the active ingredients to be alkaloids, both tertracyclic oxindole alkaloids and pentacyclic alkaloids that have been found both in the bark and in the root. The extract is obtained by boiling both the inner part of the bark and the root, each of which differs in concentration of the various alkaloids. The root is believed to better for its anti-inflammatory powers due to the quinovic acid glycoside it contains, although the relative concentrations of the various alkaloids can vary according to the time of year and to the chemotype of the plant. Cat’s Claw comes in two chemotypes, each of which differs in the relative concentrations of the two different alkaloid types. One predominates in the pentacyclic alkaloids that strengthen the immune system, and the other chemotype in the tetracyclic alkaloids that counter that effect and reduce the speed and strength of the contractions of the heart. It is not possible to tell which chemotype a particular plant is until it has been chemically tested. They look exactly the same and it is possible for both to grow sided by side. However, the root is generally richer in alkaloids, and sells at about twice the price of the bark. Alkaloids are not the only active ingredients in Una de Gato, and it also contains tannins and phytochemicals that have an antioxidant effect and are useful free radical scavengers. They have been studied for their effects in the treatment of HIV and cancer, though mainly due to the glycoside content that will be discussed shortly. The National cancer Institute has confirmed some anti-cancer properties of quinovic glycosides derived from cat’s claw. The four pentacyclic alkaloids have been found to have a boosting effect on the human immune system, which it does by enhancing the ability of the white blood cells and macrophages to digest and kill off foreign organisms and debris in tissue and the bloodstream. The inference is that the herb is able to be used to treat a wide variety of infectious diseases, including many immune and autoimmune conditions including AIDS. The results with AIDs are inconclusive, although one particular study showed that cat’s claw produced accelerated healing of cold sores and genital herpes (herpes simplex virus) and shingles (caused by herpes zoster virus). Although the evidence is slight, there are indications of its possible use in treating viral conditions. It is used in homeopathy for the treatment of a number of digestive ailments, such as Crohn’s disease, Leaky bowel syndrome, colitis, gastritis and gastric ulcers among others. It is also used in the treatment of inflammatory conditions such as arthritis, rheumatism and some conditions of the prostate gland. The tertracyclic indole alkaloids that appear to counter the immune-boosting properties of their pentacyclic cousins include rhynchophylline, hirsutine, and mitraphylline. Rhynchophylline prevents blood clots in the veins and arteries by reducing the formation of platelets, and can dilate the peripheral blood vessels of the hands and feet. It can also lower blood cholesterol levels and reduce the heart rate. Due to this effect on blood vessels, it is though to be able to improve the circulation in the brain and be a useful treatment for Alzheimer’s sufferers. Hirsutine inhibits contractions of the smooth muscle of the bladder, and so finds uses in the treatment of urinary incontinence. The pentacyclic alkaloids pteropodine and isopteropodine are believed to have important properties beyond their phagocytosis effect on the immune system. It has been reported that they have an effect on the 5-HT(2) receptors in the brain. These neurotransmitters are used as targets for many drugs used to treat a variety of conditions such as depression, eating disorders and anxiety, and such alkaloids have a positive modulating effect on them. The anti-inflammatory properties of cat’s claw are largely due to the very potent quinovic acid glycosides previously referred to. These have been known about only recently, and they are thought to work synergistically to reduce the tissue swelling (edema) associated with the immune system’s inflammatory reaction. Although this is believed to be largely due to the glycosides, three of the alkaloids also possess anti-inflammatory properties. This property provides the scientific background for the traditional use of Una de Gato for rheumatism and arthritis, both inflammatory conditions. Many of the digestive conditions for which the plant has traditionally used are also inflammatory in nature. A threat to cat’s claw is the destruction of the Peruvian rainforest, although not as much as a threat as the destruction of the plant itself. Cat’s claw has reached levels of popularity so high that it is in danger of extinction due to improper harvesting. New laws being enacted by the Peruvian government should help to protect the plant, and to promote its harvesting over cocoa. When buying cat’s claw, make sure that it is the Uncaria tomentosa form you are purchasing since there is another type, Uncaria Guianensis that contains different alkaloids and is not as potent as the real Una de Gato. Also beware of a shrub known as cat’s claw acacia, grown in Mexico and the southwest USA, since it contains cyanide derivatives and could be very dangerous if taken by mouth.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1774) Digestive Enzymes To Improve Wellness For Kids
Date:
November 04, 2007 03:19 PM
It is very safe to say that most people experience some type of digestive difficulty, as digestive disturbances are very common, especially for those who do not practice healthy eating. The numerous advertisements for antacids and acid blockers clearly identify the degree of this problem. But, what about our children? It has been proven that kids are suffering from digestive problems more than ever before due to unhealthy eating habits and nutritionally deficient diets that are high in saturated fats and processed sugars and carbohydrates. The food that is served in school cafeterias often contains too much fried food and not enough fresh produce. Additionally, parents have to constantly fight a losing battle against advertisements for junk food. Many children follow in the footsteps of their parents, picking up the same bad eating habits, which frequently leads to poor digestion and health problems. Overeating, eating too fast, or not chewing food well hinders digestive capability leading to symptoms such as gas, heartburn, bloating, burping, bad breath, diarrhea, constipation, and general discomfort or fatigue after meals. Although these symptoms are common, they should not be considered normal as they are distress signals sent by our body telling us that the digestive process is not going smoothly and we are not receiving the full nutritional benefit of the food we eat. If digestion is not efficient or complete, inflammation may develop, which causes “Leaky gut syndrome,” leading to various allergic reactions. The brain is especially susceptible to protein fragments, which come from the incomplete digestion of grain gluten and dairy casein. Researchers believe that these fragments, which are called exorphins, are the main factors in the cognitive symptoms and abnormal behaviors of those kids with ADHD and autism. A recent study on thirty-six autistic children found that a majority of these children had digestive disorders including esophageal reflux and inflammation, gastritis, duodenitis and low carbohydrate digestive enzyme levels. Some doctors believe that seventy-five percent of the children that they treat have major deficiencies of pancreatic enzymes. Enzymes are often called the spark of life or the missing link in nutrition because no plant or animal can exist without them. Digestive enzymes are protein catalysts which break down food so the body can absorb nutrients. Therefore, enzyme supplementation can be extremely helpful, especially when it is done in conjunction with dietary changes. And, yes, kids can take enzymes supplements, too. In children with digestive symptoms, enzyme supplements help to establish proper weight because better assimilation of nutrients helps growth and repair while still supporting a healthy metabolism. Digestive enzymes come in mild-potency enzyme formula which covers all of the food groups for children. Children should take a powder which is safest so there are no caps to swallow and chock on and powdered enzymes allow children to get their digestive enzymes through one scoop which can be added to your child’s favorite juice. Some formulas add potassium carbonate, this form of potassium adds a fun fizz to whatever beverage is used, but is not recommended in milk or water. Look for a powdered supplement that is sweetened with xylitol, a safe and natural sugar substitute which supports tooth and gum health. Since more children than ever suffer from the consequences of incomplete digestion, digestive enzymes are a safe and effective way to support digestion and assimilation of important nutrients into your child’s diet in an enjoyable way.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1618) Cleanse That Body!
Date:
June 14, 2005 11:59 AM
Cleanse That Body! by Lisa James Energy Times, January 6, 2005 When toxins accumulate in your tissues, you can become fuzzy and sluggish. Here's how a New Year's internal cleansing can make you feel fresh and energized. What's your New Year's resolution? Losing weight? Getting fit? Kicking the [fill-in-the-blank] habit? Whatever the shape of your dreams for 2005, it won't be easy launching a self-improvement program unless you give your body a fresh start. Where to begin? Detoxification-an internal cleansing that can supply the energy you need to succeed in achieving your goals. No one can avoid toxins in our contaminated world, so many of us suffer from toxic overload, which can lead to fatigue, digestive problems and reduced immune function. " When we get out of balance, we get congested and toxic," says Elson Haas, MD, founder of the Preventive Medical Center of Marin in San Rafael, California (www.elsonhaas.com), and author of The New Detox Diet (Celestial Arts), "and our bodies' regular elimination systems cannot keep up with it. We have problems with our skin, our intestines, our sinuses. We also become deficient in vitamins, minerals and essential fatty acids. Most people have both congestion and deficiency, and they would benefit greatly from detoxification." Toxins Within, Toxins Without Life's fundamental activities-breathing, eating, walking around-generate waste in the form of free radicals, the unstable molecules that can ravage cells and tissues. What's more, Dr. Haas says that just "being under stress, being afraid, being anxious all produce more free radicals in the body" (like when a work deadline hits on the same day your car dies). When you add to your internal toxins all the noxious items coming from the outside, including the dietary ones, the recipe is very unhealthy. " People are making poor choices in what they're putting in their mouths," says Dr. Haas. "They're taking in too much refined flour and sugar. There's a common problem in our country I call 'obese malnutrition'-people eating too many calories and not getting enough nutrition. People do a lot of junky fats and have a deficiency in the essential fatty acids that help protect cells." Our bodies are also awash in manmade poisons such as food preservatives and additives, and residues from pesticides and herbicides. "The amount of toxic chemicals we are exposed to in our environment is staggering," says Susan Lark, MD, clinical nutrition expert and author of The Chemistry of Success (Bay Books). She notes that the average American is exposed to 14 pounds of such assorted chemical junk each year. The body, however, does do its own housekeeping-and all of our cells detoxify every second of every day. "It's always a balance of garbage in, garbage out," says Dr. Haas, who has 30 years of experience in helping people detoxify. "Some of the toxins we break down into smaller components, some we just dump into the intestines for elimination." Problems arise when there's more dirt than the internal maid service can sweep away. Dr. Lark notes that toxins wind up being stored in cells, especially fat cells, where they can hang out for years. When they are finally released "during times of low food intake, exercise or stress" complaints can range from tiredness to dizziness (sound familiar?). That's where detoxification comes in, says Dr. Haas: "I think detoxification is a vital health care tool, particularly in this day and age when people are exposed to too many chemicals." Digest This The process of detoxification starts with cleansing the intestinal system. Alternative health practitioners observe that discombobulated bowels can become overly permeable (a condition called Leaky gut syndrome) and allow in all sorts of things that they shouldn't, such as semi-digested food particles, leading to inflammation and complaints that include rashes and joint pain. Cleansing can be as simple as cutting down on what Dr. Haas calls the SNACCs-Sugar, Nicotine, Alcohol, Caffeine and Chemicals-or as thorough as a complete diet-and-supplement program with colonic irrigation (a sort of super-enema, professionally administered; if you're interested, contact the International Association of Colon Hydrotherapy at 210-366-2888 or www.i-act.org). The more powerful the program, though, the more likely you are to experience toxicity reactions such as nausea and headaches because of the volume of material being released. As Dr. Haas puts it: " If you did water and green salads for a week, you'd detoxify more intensely than if you just gave up sugar and white flour." If you're feeling extremely rundown, take a gentle approach at first or consult a nutritionally aware practitioner, especially if you have a preexisting medical condition. Getting more fiber is essential. Laurel Vukovic, a natural health teacher and author of 14-Day Herbal Cleansing (Prentice Hall), suggests following this daily regimen for two weeks: a teaspoon of psyllium (a fiber supplement); at least seven daily servings of fruits and vegetables, especially fiber-rich ones like apples, cabbage and carrots; and six glasses of water, along with daily exercise. Extra fiber "supports the intestines in eliminating the larger amounts of toxins that are released," says Vukovic, "prevent[ing] their reabsorption into the bloodstream." Some people find premixed cleansing formulas convenient; check your health food store shelves. Fasting is a more intense detox approach that, according to Dr. Haas, "promotes relaxation and energization of the body, mind and emotions, and supports a greater spiritual awareness." He especially recommends fasting in the spring and autumn, which are times of transition. Some people do water-only fasts, but fresh vegetable juices are probably a better option, particularly if you haven't fasted before. Juices and plenty of fresh water also help cleanse the kidneys, another vital detox route. Instead of juices you can use a special cleansing formula, such as the Spring Master Cleanser: 2 tablespoons freshly squeezed lemon juice, 1 tablespoon pure maple syrup and 1/10 teaspoon cayenne pepper in 8 ounces of spring water. Dr. Haas recommends drinking eight to 12 glasses daily (and rinsing your mouth after each glass to protect your teeth from lemon's acids), augmented by water, laxative herb tea, and peppermint or chamomile tea. Try fasting for a day to see how you feel. Dr. Haas suggests starting out by fasting from early evening through the night, and eating a light breakfast the following day. Subsequent fasts can gradually increase in length-experienced fasters may go up to two weeks without food. Break your fast properly; for juice or cleansing formula fasts, eat a raw or cooked low-starch vegetable, such as spinach or other greens. "Go slowly, chew well and do not overeat or mix too many foods at any meal," says Dr. Haas. Don't forget your liver, the organ that transforms noxious chemicals into substances your body can eliminate. The herb milk thistle, used since ancient times as a liver tonic, contains silymarin, which protects the liver from pollutants and helps it renew itself after toxic damage. Dandelion not only promotes the flow of bile from the liver, which helps clean out the junk, but also acts as a diuretic, helping the kidneys do their job. Green-food supplements, such as spirulina and cereal grasses, help neutralize toxins. To maintain your cleansing gains, eat a healthy diet after detoxing. Focus on fresh organic foods, especially produce, beans and peas, whole grains and seeds (add organic poultry if you eat meat). Organic yogurt provides healthful probiotics, while fresh fish and ground flaxseeds provide omega-3 fats. Clean Living Pays The body's largest organ-the skin-provides a valuable contaminant exit path. Sitting in a hot tub or sauna "benefits the internal organs of detoxification," according to Dr. Lark, "by lessening the amount of toxins they must process." When sweatin' out the bad stuff, drink plenty of water and replace the calcium, magnesium and potassium lost through perspiration. Another way to stimulate skin circulation is dry brushing, which also removes dead skin cells for a healthy glow (and is easier to fit into a daily routine). Using "a moderately soft, natural vegetable-fiber bristle brush" (Dr. Lark's suggestion), work in from the hands and up from the feet with light, short strokes that always move towards the heart. Vukovic says that a hot towel scrub is another option; put three drops of lavender essential oil in a basin of very hot water, dip in a rough terry washcloth and wring out, and then rub the skin briskly, starting with your feet and working your way up. Once you've detoxified your body, you can start in on your immediate surroundings. Dr. Haas warns against using plastic food storage containers: "When food is heated in plastics some of the plastic material ends up in the food, especially if the food contains acids." Use glass containers instead. He also recommends avoiding aluminum pots and pans, and using stainless steel as an alternative. Dr. Haas has seen what a good detox program can do: "It's amazing the kind of results people get-looking and feeling younger, more vital and healthy. They say, 'I'm sleeping like a baby,' they have fewer aches and pains. They have more peace in their bodies. I think detoxification is one of the keys to preventive medicine." So cleanse that body and let detoxification bring balance and renewal to your life.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=348) Maximum Absorption
Date:
June 10, 2005 03:24 PM
Maximum Absorption by Henry Wolfe Energy Times, July 11, 2003 Nutrients do you no good if you don't absorb them. Eating the right stuff and taking the right nutrients can still be wrong if they never make it out of your digestive tract and into your bloodstream. For instance, dietary supplements usually should be taken along with food. The presence of food in the digestive tract aids the absorption of nutrients. As a general rule, if you take dietary supplements on an empty stomach, most of their contents will probably pass through you and never escape your intestinal tract before they are eventually eliminated. This is particularly true for the fat-soluble nutrients such as vitamins A, D and E. By consuming fatty foods when you take these supplements, you enable your body to absorb a large amount of these valuable substances. But there is at least one exception to this rule: Amino acid supplements (protein building blocks) should usually be taken on an empty stomach. Otherwise the other amino acids present in your meal may interfere with your use of these nutrients and counteract the benefits of the supplements. The Standardization of Herbs Taking herbs presents different challenges than consuming dietary supplements. While the chemical structures of nutrients in supplements are usually precisely identified, the active ingredients in herbs is usually a mixture of chemicals. Often, too, researchers disagree on exactly which active ingredients in herbs produce the health benefits linked to these botanicals. But in an effort to derive the most from these substances, many experts recommend what are called standardized forms. Standardized herbal supplements are formulas that have been created to insure they contain consistent and reliable amounts of certain beneficial chemicals that scientists have identified in these plants. In the creation of these supplements, experts determine the standardized chemicals that are most likely the basis of the herbs' effectiveness. By standardizing certain of the supplements' ingredients, therefore, standardized herbs limit the variation among batches of the product. You can rely on the fact that every purchase will contain the same amount of ingredients taken from the original plant. According to Michael Janson, MD, author of Dr. Janson's New Vitamin Revolution (Penguin/Avery), "Although herbs have a long history of use for medicinal purposes, it is only recently that they have been analyzed to reveal their most active components. These active chemicals are commonly present in very variable amounts in herbs, depending on where and how they are grown, soil quality, when they are harvested, the amount of rain and sun, and other factors. "Standardized herbs have guaranteed specific amounts of the known, active herbal components, as well as the other factors that might be of help but are not as well studied" (www.drjanson.com). Herbalists who specialize in using entire plants in their practices can recommend non-standardized preparations that you can often use. In general, that kind of herbal use is more effective when you secure expert advice. If you lack access to an experienced herbalist and you're choosing botanicals on your own, standardized preparations are easier to take. Absorption From the Gut Most of the nutrients you take in are absorbed through the walls of your digestive tract. This most often takes place in the small intestine. What to watch out for: Fast food, fast living and long work hours afflicts our digestion and can disrupt proper absorption. You have to be relaxed to properly absorb the nutrients in your food and supplements. Consequently, the occasions for meals should be relaxed and enjoyable moments. Set aside enough time to appreciate, taste and thoroughly chew your food. Adequate digestion and absorption begin in your mouth. Another way to increase nutrient absorption is with the use of digestive enzymes. Since the digestive tract depends on the enzymatic breakdown of food that reduces nutrients to absorbable form, taking enzymes can help your intestines make better use of nutrients as they pass through the digestive tract. Normally, enzymes are present in raw food, like uncooked fruits and vegetables. Since most of our food is eaten after it is heated, a process that breaks down enzymes, not many enzymes are present in today's diet. Therefore, taking supplemental enzymes may increase absorption. Beyond Stress Beyond everyday stress, a variety of problems can make absorption go astray, allowing important nutrients to escape and permitting unwanted substances to enter the body. For instance, a significant digestive malfunction that many experts have focused on in recent years is a condition that has come to be called "Leaky gut." As Anil Minocha, MD, director of digestive diseases at the Mississippi Medical Center and author of Natural Stomach Care (Avery), points out, "In a healthy individual, the wall of the intestinal tract is designed to absorb food molecules and prevent harmful microorganisms and toxic materials from passing out through the bowel wall and into the bloodstream. "In today's heavily polluted environment, the gastrointestinal tract of even the healthiest individual is called on to process an overwhelmingly large flow of septic and infectious materials." Because of these digestion destroyers, as we take in a startlingly large amount of viruses, bacteria, toxic chemicals, fungi and processed foods, our digestive systems are often overwhelmed and are rendered unable to perform their tasks correctly. This constant assault on the stomach and intestines takes a serious toll. A frequent product of this process is the digestive walls' loss of their crucial ability to keep out unwanted toxins and organisms as they become, in Dr. Minocha's words, "loosened and inflamed." As a result, instead of keeping out harmful substances and absorbing helpful nutrients, spaces open up that begin to allow in "bulky, partially digested food particles, toxic substances and infectious microbes." According to Dr. Minocha, the first signs of this absorption problem can include complaints such as allergic reactions, skin problems, joint pain, digestive difficulties, nausea, fatigue and lack of energy. To improve your digestive absorption, Dr. Minocha recommends a six-part program that includes these steps: * Detoxification by means of fasting and avoiding harmful items like sugar, over-processed foods, coffee and alcohol * Taking herbs that can help the digestive tract heal, recover and repair itself; these include garlic, ginger and milk thistle * Replenishing the beneficial bacteria of the digestive tract by eating yogurt * Keeping track of your daily diet and eliminating foods that cause allergies and other reactions * Consuming more fruits and vegetables while eating a high-fiber, mostly vegetarian diet * Developing consistent, healthy lifestyle habits; these include not smoking, cutting the size of your meals and eating in moderation, exercising several times a week and controlling stress Young and Old Digestion The nutrients in your diet can also beneficially influence the state of your digestive system and its ability to distinguish among substances that are supposed to gain entrance to your body and those that should be kept out. Since aging can further compromise the discriminatory ability of your gut, Dr. Minocha also recommends a steady diet of antioxidant-rich fruits and vegetables plus supplements to keep your digestive tract functioning at full capacity as you grow older. Among the nutrients he recommends: * Coenzyme Q10: By middle age, your body makes less of this powerful antioxidant that helps cells generate energy in the mitochondria (structures within cells that may decrease with age). Dr. Minocha notes that research demonstrates CoQ10 may be able to help people with diabetes control harmful metabolic byproducts that appear in their bloodstreams. * Natural Lycopene: This antioxidant, responsible for the red of both tomatoes and watermelon, has been shown to lower the risk of both heart disease and prostate cancer. As an antioxidant, natural lycopene also helps protect the digestive tract. Absorption of the proper nutrients may be the key to health for many people. By paying closer attention to the well-being of your digestive tract and practicing lifestyle habits that promote maximum absorption, you may be able to substantially improve your nutrition and your health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=269) 
Date:
May 09, 2005 06:10 PM
It's in the BloodNatural alternatives abound for managing cholesterol levels, backed by a growing body of research ©VR By Paul BubnyThe National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen. “The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks. “Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).” At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke. While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!” Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.” And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.” Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.” King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.” Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.
"Blur of Products"With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.” To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following: Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent. Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels. Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.” “The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.” On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone. Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients. Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs. Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic. Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action. Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.” Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take. “Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels. Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids. Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period. “The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake. For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.” Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients. Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO. Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols. Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol. Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky. “In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.” Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.” Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said. However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.” Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.” Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols. Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”
New WeaponsThere are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise. With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.” Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch Leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM. “Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR Vitamin Retailer Magazine, Inc., 431 Cranbury Road, East Brunswick, NJ 08816 //www.oprmagazine.com/
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