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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Unlocking Your Cellular Vitality: Understanding the Role of Mitochondria in Energy and Aging
Date:
September 09, 2026 05:22 PM
Introduction: Understanding Cellular Aging and Energy DeclineHave you ever wondered why you could bounce back from an all-nighter or an intense workout in your twenties, but in your forties or fifties, the same physical effort leaves you feeling drained for days?Most people think aging is something that happens strictly on the outside - fine lines around the eyes, stiff joints, or gray hairs. In reality, aging begins at a microscopic scale inside your cells, the microscopic building blocks that make up every tissue, muscle, and organ in your body. Every single day, your body relies on roughly 30 trillion cells working in unison. When your cells are young and resilient, they operate like a well-oiled machine: they repair minor damage instantly, clear away waste, and produce abundant energy. But over time, two fundamental biological shifts take place:
The Role of Mitochondria and ATP ProductionTo understand where your daily energy comes from, you have to look inside your cells at tiny structures called mitochondria.Often called the "powerhouses" of the cell, mitochondria function like miniature power stations. A single cell can house hundreds or even thousands of them, especially energy-hungry cells like those in your heart, brain, and skeletal muscles. The Body’s Energy Currency: What is ATP?Your body cannot directly use a sandwich or a cup of coffee to power muscle contractions or brain signals. Instead, your mitochondria take the nutrients from your food and combine them with the oxygen you breathe to manufacture a chemical molecule called adenosine triphosphate (ATP).Think of ATP as your body’s universal energy currency:
Why Cellular Energy Production Declines with AgeWhen you are young, your mitochondria are abundant, pristine, and remarkably efficient. However, the very process of creating energy comes with an unavoidable side effect: oxidative stress.Much like an engine produces exhaust fumes while burning fuel, mitochondria produce reactive byproducts known as free radicals (reactive oxygen species). Over decades, these "exhaust fumes" slowly damage the inner machinery of the mitochondria:
How Cellular Senescence Accelerates the Aging ProcessIf mitochondrial decline is a problem of power shortage, cellular senescence is a problem of biological clutter and pollution.In a healthy body, normal cells follow a strict lifecycle: they divide, perform their jobs, and when they incur significant damage or reach the end of their useful lifespan, they undergo a tidy self-destruction process called apoptosis (programmed cell death). Your immune system then clears away the debris, making room for fresh, vibrant cells. Cellular senescence happens when this cleanup process fails. The "Zombie Cell" PhenomenonWhen a cell experiences extreme stress - such as shortened telomeres (the protective caps on chromosomes), severe DNA breaks, or severe mitochondrial dysfunction - it reaches a biological crossroads. To prevent the damaged cell from dividing uncontrollably (which could lead to tumors), the body puts the brakes on.The cell enters a permanent state of dormancy:
Why Zombie Cells Are So Damaging: The Bad Apple EffectHaving a few retired cells hanging around might not sound catastrophic, but senescent cells do not sit quietly. Instead, they secrete a toxic chemical cocktail known as the Senescence-Associated Secretory Phenotype (SASP).This cocktail is packed with pro-inflammatory cytokines, chemokines, and tissue-degrading enzymes. Picture one spoiled apple sitting in a fruit basket: the ethylene gas it emits quickly causes the healthy apples surrounding it to rot. In the same way, the toxic secretions from zombie cells:
The Vicious Cycle of Cellular AgingMitochondrial decay and cellular senescence are not isolated events; they feed directly into one another:
What This Means for Everyday HealthThe good news from modern longevity science is that cellular decline is not entirely out of our hands. While aging is natural, the rate at which our cellular engines degrade can be influenced by daily habits:
Summary: Aging is fundamentally a microscopic process occurring inside the body's trillions of cells, which naturally become less resilient over time. Central to this decline are the mitochondria, the tiny structures that function as the cell's "power plants" to produce adenosine triphosphate (ATP), the universal chemical currency for everyday energy. While young mitochondria are abundant and pristine, decades of producing ATP generate oxidative stress through byproducts called free radicals, which eventually wear down and damage mitochondrial DNA and machinery. This damage results in fewer, less efficient power generators, lowering total cellular energy output, which individuals experience as real-world physical fatigue and mental fog. Aging is further accelerated by cellular senescence, a condition where damaged cells stop dividing but, instead of naturally self-destructing like healthy ones, linger behind as dormant "zombie cells." These senescent cells secrete a pro-inflammatory chemical mixture known as the Senescence-Associated Secretory Phenotype (SASP), which functions like a "bad apple" by poisoning healthy neighboring cells and tissues, creating a state of chronic biological pollution termed "inflammaging." Mitochondrial decay and senescence feed into one another in a vicious cycle that directly drives overall aging. However, longevity science highlights that healthy lifestyle habits, including regular exercise and periods of fasting, can support continued vitality by encouraging the development of new mitochondria and the clearing of this toxic cellular clutter.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6649) Is Your Cinnamon Causing Inflammation? The Hidden Risks of a Common Spice
Date:
July 16, 2026 05:28 PM
Cinnamon is widely praised for its ability to improve cellular glucose uptake and support insulin sensitivity, but the direct answer is yes - under specific conditions, consuming cinnamon can cause or trigger inflammation. While cinnamon naturally contains powerful anti-inflammatory polyphenols (like cinnamaldehyde), its potential to drive inflammation boils down to two distinct triggers: the specific variety you ingest, and your individual immune response to its volatile oils. 1. Coumarin-Induced Liver InflammationThe primary metabolic risk stems from Cassia cinnamon, which is the standard, inexpensive variety found on most grocery store spice racks. Cassia contains significant concentrations of a naturally occurring compound called coumarin.
2. Contact Hypersensitivity (Cinnamon Stomatitis)Cinnamaldehyde gives cinnamon its signature warmth and flavor, but it is also a documented contact allergen.
3. Gastrointestinal Mucosal IrritationBecause concentrated spice powders contain highly concentrated volatile oils, taking large doses on an empty stomach can physically irritate the delicate mucous lining of the upper gastrointestinal tract. This localized chemical irritation can mimic or exacerbate inflammatory discomfort in the stomach wall, resulting in heartburn, acid reflux, or cramping.Mitigating the Risk: Ceylon vs. CassiaIf you are leveraging cinnamon as a daily tool for metabolic health and blood sugar management, switching to Ceylon cinnamon (often labeled as "True Cinnamon") fundamentally changes its biochemical impact.
While cinnamon is highly regarded for improving insulin sensitivity and managing blood sugar, it can paradoxically trigger inflammation under specific conditions. The primary systemic risk stems from Cassia cinnamon, the common grocery store variety, which contains high concentrations of a compound called coumarin. When consumed regularly or in large therapeutic doses, coumarin can overwhelm the liver's metabolic pathways, leading to elevated liver enzymes and acute hepatic inflammation. Beyond liver toxicity, cinnamon can also incite localized inflammation; its volatile oil, cinnamaldehyde, can induce a Type IV delayed hypersensitivity reaction known as contact stomatitis - causing painful burning and swelling in the mouth - while concentrated doses can physically irritate the gastrointestinal lining. To safely harness the metabolic benefits of the spice without triggering these inflammatory responses, switching to Ceylon cinnamon ("true cinnamon") is the most effective strategy. Systemically, Ceylon contains only trace, negligible levels of coumarin (0.004% to 0.007%), making it safe for daily medicinal dosing, whereas Cassia contains significant levels (up to 1.0%) that require strict consumption limits to avoid toxicity. Visually and structurally, the two varieties are distinctly different: Ceylon features a light tan color with multiple thin, fragile, and tightly rolled layers, while Cassia is characterized by a dark reddish-brown hue and a single, thick, hard quill that is difficult to break.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6645) Choline: The Liver’s Fat-Export Engine
Date:
June 24, 2026 11:48 AM
Without sufficient choline, the liver's ability to process and export fats grinds to a halt. The Liver’s Fat-Export MechanismThe primary reason the liver requires choline comes down to a specific molecule: phosphatidylcholine (PC).When you eat fats or liberate stored fatty acids, your liver processes them into triglycerides. To move these triglycerides out of the liver and deliver them to muscle or adipose (fat) tissue for energy or storage, the liver has to package them into transport vehicles called VLDL (Very Low-Density Lipoproteins). Phosphatidylcholine forms the essential outer shell of these VLDL transport "boats." If you don't have enough choline, your liver cannot manufacture this outer shell, meaning the boats cannot be built, and fat cannot leave the liver. What Happens When Choline is Deficient?When dietary choline drops below critical levels, a highly predictable cascade of liver dysfunction occurs:
Dietary Benchmarks & SourcesTo prevent fat accumulation and support proper VLDL export, the Food and Nutrition Board establishes specific Adequate Intake (AI) targets, though optimal metabolic and athletic performance may require a more robust baseline.
Summary: Choline acts as a critical logistics coordinator for liver health, serving as a non-negotiable raw material for exporting fat out of the organ. Specifically, the liver relies on choline to produce phosphatidylcholine, a molecule that forms the essential outer shell of Very Low-Density Lipoproteins (VLDL). Think of VLDLs as transport boats designed to safely carry triglycerides out of the liver and deliver them to the rest of the body for energy or storage. Without an adequate dietary supply of choline, the liver simply cannot build these outer shells, causing the entire transport system to grind to a halt and leaving processed fats stranded inside liver cells. When this export mechanism stalls, the stranded fat quickly triggers a highly predictable cascade of liver dysfunction. This buildup leads directly to fat accumulation - historically known as fatty liver disease and now classified as MASLD - which quickly overwhelms the cellular mitochondria. The resulting oxidative stress and cellular injury spark chronic inflammation (MASH), causing liver cells to die and potentially leading to permanent scarring or fibrosis over time. Furthermore, a severe shortage of dietary choline starves the body's methylation cycle, forcing it to deplete vital SAMe pools in a desperate, structurally taxing attempt to manufacture its own phosphatidylcholine.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6643) The Dual Action of DLPA: Endorphin Shielding and Neurotransmitter Support
Date:
May 22, 2026 12:27 PM
What is DLPA and How Does It Help Relieve Pain? DLPA (DL-phenylalanine) is a nutritional supplement that offers a unique approach to managing chronic pain. Instead of suppressing inflammation or directly numbing nerves like over-the-counter pain relievers, DLPA works by protecting and prolonging the body’s own built-in painkillers. To understand how it works, it helps to break down the molecule. DLPA is a 50/50 mixture of two stereoisomers (mirror-image structures) of the essential amino acid phenylalanine:
How D-Phenylalanine Relieves PainThe human body has an endogenous analgesia system—a built-in network for managing pain perception. D-phenylalanine acts as a biochemical shield for this system through a very specific mechanism:
Why Include the "L" Form?You might wonder why a supplement doesn't just use pure D-phenylalanine if that's the part that stops the pain.Chronic pain rarely exists in a vacuum—it is deeply linked to systemic fatigue, mood degradation, and depression. Because chronic pain is neurologically exhausting, it frequently depletes the brain's stimulating neurotransmitters. The L-phenylalanine half of DLPA acts as the raw precursor material for the catecholamine pathway. Your body converts it into tyrosine, which is then synthesized into dopamine, norepinephrine, and epinephrine (adrenaline). By combining both forms, DLPA provides a dual-action effect: the D-form raises the pain threshold, while the L-form combats the mental fatigue and mood dips that inevitably accompany long-term discomfort. Key insight: Because DLPA relies on shifting enzyme levels and allowing endorphins to accumulate, it is primarily effective for chronic pain (like osteoarthritis or lingering injuries) rather than acute, immediate pain. It often requires several days to weeks of consistent use to reach its full therapeutic effect. Summary: DLPA (DL-phenylalanine) is a nutritional supplement combining two mirror-image forms of an essential amino acid to provide a unique approach to chronic pain management. Unlike standard pain relievers that suppress inflammation, the "D" form of the molecule acts as a biochemical shield for the body's built-in painkilling system. It functions as an enkephalinase inhibitor, meaning it blocks the specific enzymes responsible for destroying circulating endorphins and enkephalins. By protecting these natural opioids from premature breakdown, DLPA allows them to accumulate and remain active longer, effectively raising the body's natural pain threshold. Because chronic pain is neurologically exhausting and frequently leads to fatigue or lowered mood, the "L" half of the supplement provides critical mental support. L-phenylalanine serves as a raw precursor for synthesizing stimulating neurotransmitters, including dopamine, norepinephrine, and epinephrine (adrenaline). Together, this dual-action mechanism addresses both the physical sensation of lingering discomfort and the mental fatigue that accompanies it, making DLPA uniquely suited for sustained, long-term pain conditions rather than immediate, acute injuries.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6639) Is NAD+ the "Missing Link" in Modern Longevity Science?
Date:
April 11, 2026 12:24 PM
How NMN Boosts NAD+ LevelsNMN is essentially a "building block" for NAD+. The process by which the body converts NMN into NAD+ is relatively direct, making it an efficient supplement for raising levels.
Why Boost NAD+? The Biological BenefitsNAD+ is a "coenzyme" found in every single living cell. It is required for over 500 different enzymatic reactions. Here are the primary reasons why maintaining high NAD+ levels is critical for health:1. Cellular Energy Production (ATP)NAD+ plays a starring role in the mitochondria, the powerhouses of the cell. It acts as an electron carrier in the process of turning nutrients from food into ATP (Adenosine Triphosphate), which is the primary energy currency of the body. Without enough NAD+, cellular energy production falters, leading to fatigue and decreased metabolic function.2. DNA Repair and StabilityOur DNA is constantly under attack from UV radiation, pollutants, and metabolic byproducts. To fix this, the body uses enzymes called PARPs (Poly ADP-Ribose Polymerases). These enzymes are strictly "NAD+-dependent," meaning they cannot function without consuming NAD+. By boosting NAD+, you provide the fuel necessary for cells to repair genetic damage effectively.3. Activation of Sirtuins (The "Longevity Genes")Sirtuins are a family of proteins responsible for cellular health, aging, and DNA protection. They are often called "guardians of the genome."
4. Metabolic Health and Insulin SensitivityResearch indicates that increasing NAD+ through NMN can improve glucose metabolism and insulin sensitivity. This is particularly relevant for maintaining a healthy weight and reducing the risk of age-related metabolic disorders.5. Circadian Rhythm RegulationNAD+ levels fluctuate throughout the day and help regulate the body’s internal clock (the circadian rhythm). Maintaining healthy levels helps ensure that your cells know when to be active and when to undergo repair, which can improve sleep quality and daytime alertness.Note: While NMN is widely studied in animal models with promising results regarding lifespan and healthspan, human clinical trials are ongoing to fully confirm long-term efficacy and optimal dosage. Always consult a healthcare professional before starting new supplements. Furthermore:While the basics of NMN and NAD+ focus on energy and aging, there is a much deeper layer to this "master molecule" that involves cellular theft, "zombie" cells, and the critical importance of a process called methylation.Here are the vital pieces of the NAD+ puzzle that aren't usually mentioned: 1. The "NAD+ Thieves": CD38 and InflammationBoosting NAD+ with NMN is only half the battle; the other half is stopping the "thieves" that steal it.
2. The Methylation Connection (Why you need TMG)This is perhaps the most important practical detail for anyone taking NMN.
3. The "Double-Edged Sword" of CancerNAD+ is essential for all living cells, including cancer cells.
4. Regulatory Status (The 2026 Update)The legal status of NMN has been a rollercoaster. In late 2022, the FDA initially ruled that NMN could not be marketed as a supplement because it was being investigated as a drug. However, as of late 2025, the FDA issued updated guidance essentially reinstating NMN’s status as a legal dietary ingredient, clearing the way for its continued sale in the U.S.5. Natural Boosters and "Sirtuin Activators"Supplementing NMN is just one way to boost the system. You can also:
Are you planning to focus your blog post on the anti-aging benefits for a general audience, or would you like to lean more into the technical "biohacking" side of science?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6636) SCFAs Improve Mitochondria Function Throughout The Body
Date:
December 05, 2025 04:06 PM
Quick Summary: How SCFAs Help Mitochondria
Specific Benefits by Body Part1. Skeletal Muscle (Energy & Endurance)
2. Liver (Detox & Metabolism)
3. Brain (Neuroprotection)
4. Brown Adipose Tissue (Fat Burning)
Key Mechanisms
Does boosting Mitochondria boost overall body energy production and help people feel better?Yes, absolutely. Boosting mitochondrial function is one of the most effective ways to increase overall body energy and improve subjective well-being.Since mitochondria produce about 90% of the energy (ATP) your body uses, improving their function is like upgrading the engine in a car: you get more power, better fuel efficiency, and a smoother ride. Here is the breakdown of how boosting mitochondria translates to "feeling better" physically and mentally. 1. The Physical Energy Boost (ATP Production)When you improve mitochondrial density (the number of mitochondria) and efficiency (how well they work), you directly increase your "energy budget."
2. The Mental & Mood Boost (Neurotransmitters)The brain consumes 20% of your body’s energy despite being only 2% of your weight. It is incredibly sensitive to mitochondrial health.
3. How to "Boost" Them (Actionable Science)You can stimulate Mitochondrial Biogenesis (growing new mitochondria) through specific signals:
Connection to your previous questionThis connects directly to the SCFAs we discussed. When your gut produces SCFAs (like butyrate), they travel to your brain and muscles and literally feed these mitochondria, helping them produce this energy.Which specific supplements (like PQQ or CoQ10) have the strongest clinical evidence for triggering mitochondrial biogenesis?This is an exciting area of research because we now have human clinical trials showing we can actually "grow" new mitochondria (biogenesis) and clean out old ones (mitophagy) using specific compounds.Here are the top supplements with the strongest evidence for mitochondrial health, categorized by how they work. 1. The "Biogenesis" Trigger: PQQ (Pyrroloquinoline Quinone)PQQ is currently the gold standard for generating new mitochondria.
2. The "Quality Control" Agent: Urolithin AWhile PQQ builds new engines, Urolithin A recycles the old, broken ones.
3. The "Fuel" Supplier: CoQ10 (Coenzyme Q10)CoQ10 doesn't necessarily build new mitochondria, but the ones you have literally cannot work without it.
4. The "Signal" Booster: Nicotinamide Riboside (NR)This is a form of Vitamin B3 that boosts NAD+ levels.
Summary Table: What should you take?
Optimizing mitochondrial health is a systemic strategy that links gut health to overall vitality, largely driven by Short-Chain Fatty Acids (SCFAs) like butyrate, which act as both fuel and signaling agents to enhance energy production in the brain, muscles, and liver. By stimulating mitochondrial biogenesis (the creation of new energy factories via the PGC-1a gene) and fueling the Electron Transport Chain, SCFAs - along with targeted supplements like PQQ, CoQ10, and Urolithin A - directly increase ATP output while simultaneously clearing out damaged cells through mitophagy. This biological upgrade results in tangible benefits, including sustained physical endurance, sharper cognitive focus, and stabilized mood, effectively turning the body’s cells into more efficient engines that produce more power with less oxidative "exhaust."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6630) The Controversial Future of Lab-Grown Meat
Date:
June 07, 2024 12:10 PM
The Controversial Future of Lab-Grown MeatLab-grown meat, also called cultured or cell-based meat, is a new tech stirring hope and controversy in food. This method produces animal meat without slaughtering, offering an alternative to livestock farming. It could revolutionize protein thinking by reducing environmental impact and addressing ethical concerns. However, as with any new technology, there are significant debates surrounding its safety, health implications, and overall viability.
How Lab-Grown Meat is ProducedThe process of producing lab-grown meat begins by taking a small sample of animal cells, often through a harmless biopsy. These cells, typically muscle cells, are then placed in a nutrient-rich culture medium that mimics the environment within an animal's body. The culture medium contains essential nutrients like amino acids, sugars, and growth factors that encourage the cells to divide and grow. Over time, these cells multiply, differentiating into muscle tissue, which can then be harvested, processed, and formed into meat products. This process, often taking place in bioreactors, aims to replicate the natural muscle growth seen in animals. By controlling the environment meticulously, scientists can produce meat that is structurally and nutritionally similar to conventionally farmed meat. Despite the technological advancements and potential benefits, there is still a wave of skepticism and resistance against lab-grown meat, primarily centered on health risks and the idea of naturalness.
Health Risks: The Skeptics' ViewpointCritics of lab-grown meat often argue that these products are unnatural and potentially harmful. They highlight the use of a synthetic culture medium and artificial scaffolding materials to structure the tissue as primary concerns. One common criticism is that the long-term health effects of consuming lab-grown meat are unknown. Since this technology is still relatively new, there hasn't been enough time to study the impact it may have on human health comprehensively. Another significant concern revolves around the additives and growth factors used in the culture medium. Skeptics claim that consuming these substances, some derived from non-food-grade sources, could lead to unintended side effects over time. Moreover, contaminants introduced during the production process may pose risks absent in naturally grown meat. Some also point to the lack of regulatory standards and oversight for lab-grown meat as a potential risk. Since this is a new industry, the guidelines for safety, production, and labeling are still evolving. This uncertainty contributes to the fear and resistance among certain consumer groups and policymakers.
Regulatory Response: States Banning Lab-Grown MeatIn light of these concerns, some states have taken a firm stance against lab-grown meat. Florida and Arizona, for example, have enacted bans prohibiting the sale of cultured meat products. These states argue that there is insufficient evidence to guarantee the safety and health benefits of lab-grown meat. They also see these bans as a way to protect consumers and promote traditional agriculture practices. Florida's legislative body expressed concerns about the potential economic impact on the state's agriculture sector, which relies heavily on cattle farming. By banning lab-grown meat, they aim to safeguard the livelihoods of local farmers and ensure the sustainability of rural communities. Similarly, in Arizona, legislators emphasized the naturalness and cultural significance of traditionally farmed meat, viewing lab-grown alternatives as a threat to their state's heritage. These bans have sparked debates on innovation in our food system and if regulators overlook new technologies too hastily. Lab-grown meat supporters argue that these bans impede progress and limit consumer choice for ethical, eco-friendly products.
Why Naturally Grown Meat is Better and HealthierDespite the potential benefits of lab-grown meat, many still advocate for naturally grown meat as the superior option. First and foremost, naturally grown meat has a long history of consumption, providing a well-documented track record of its health effects. Unlike lab-grown meat, which relies on new and untested methods, natural meat comes from animals that have been bred and raised for generations. One of the key arguments in favor of naturally grown meat is the lack of artificial additives and synthetic processes. Animals on well-managed farms have open pastures, a varied diet, and humane living conditions, resulting in meat free from artificial additives. Natural meat can be organic and free-range, meeting consumers' health and ethical standards. Nutritionally, naturally grown meat offers high levels of essential nutrients, including vitamins, minerals, and healthy fats. Grass-fed and pasture-raised animals, especially known for producing meat with higher omega-3 fatty acids and lower saturated fat content, have well-documented nutritional benefits supported by extensive research, giving health-conscious consumers peace of mind. Another argument for naturally grown meat is its cultural and environmental significance. Traditional farming practices contribute to biodiversity, support local economies, and maintain rural landscapes. Lab-grown meat, on the other hand, often involves centralized production that may not offer the same level of environmental benefits.
In The FutureThe future of lab-grown meat remains a contentious topic, with passionate arguments on both sides of the debate. This innovative technology shows promise for changing our food system, tackling ethical issues, and lessening environmental impact. However, it sparks questions about health risks, regulations, and long-term sustainability. With some states considering bans on cultured meat, the dialogue on food values evolves. Choosing between lab-grown and naturally raised meat will hinge on personal preferences, values, and emerging scientific evidence.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6614) CuraMed by Terry Naturally
Date:
February 14, 2024 05:33 PM
Experience the transformative power of nature with CuraMed by Terry Naturally, a prized elixir that encapsulates the essence of health and vitality. Imagine a single ingredient, BCM-95® Curcumin, with a heritage spanning centuries, now delivered to you in its most potent and absorbing form. Curcumin, derived from the ancient turmeric root, is revered for its remarkable anti-inflammatory properties and its ability to fiercely protect your cells from oxidative stress and damage. Step into a story where wellness intertwines with tradition, where each capsule of CuraMed holds the secret of age-old wisdom fused with cutting-edge technology. Feel the comfort of knowing that you're nourishing your body with an extract that's up to 700% more bioavailable than standard turmeric, thanks to the unique process that melds curcumin with essential oils to enhance absorption. Like a golden drop of sunshine, each dose is a concentrated beacon of health. Envision a life where every day is filled with the vigor you desire. CuraMed by Terry Naturally offers that vitality by maintaining a healthy inflammation response in the body, supporting your joints, brain, heart, and immune system. The power of BCM-95® Curcumin is more than just an antioxidant; it's a commitment to your long-term wellbeing, ensuring that with every capsule, you're paving the path to a vibrant life. Begin a journey where each morning promises a leap towards wellness. With CuraMed's unparalleled potency, imagine fewer pills and yet feeling the invigorating impact of curcumin flooding through your body, like a wave of restorative energy. It's not just about alleviating the pains of today, but about investing in the joys of your tomorrows. CuraMed by Terry Naturally isn't just a supplement; it's an ally in your quest for a life brimming with health. Embrace the science of nature with a product that stands apart in its commitment to pure, powerful ingredients designed for maximum impact. Let CuraMed be the guardian of your health, guiding you to a life where every day feels like a breath of fresh air, clear mind, and a resilient, thriving body.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6594) Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592) six top-notch supplements that can help you achieve your goals.
Date:
December 06, 2023 04:55 PM
If you're looking to stay in the game longer and improve endurance while promoting rapid recovery, we've got you covered! six top-notch supplements that can help you achieve your goals.For most of us, life can feel like quite the balancing act. In an ideal world, we would all have ample time throughout the day to dedicate to our health and well-being. However, reality paints a different picture, where 24 hours can seem like an insufficient amount of time to squeeze in work, school, family, and the countless responsibilities that life throws at us. In recent years, the use of supplements for recovery has gained popularity, becoming more common than ever before. Our bodies face a barrage of daily stresses, including exposure to environmental toxins, electromagnetic pollution, and the strain of intense physical activity. These factors increase our body's demands for antioxidants and essential nutrients that aid in the process of recovery. While consuming antioxidant-rich foods can certainly make a difference, it can be challenging to meet these requirements solely through our diet. That's where a well-rounded supplement regimen can play a crucial role in promoting optimal health and aiding in recovery. Even with our best efforts to exercise regularly, eat nutritious meals, and get sufficient sleep, life in the 21st century can be incredibly demanding, depleting our bodies on a cellular level. For athletes, consistent training is key to reaching desired performance levels. It's important to understand that the muscle recovery and building process primarily occurs between gym sessions. Developing a comprehensive recovery strategy during this crucial window, through the use of supplements, proper nutrition, and adequate rest, can help athletes perform at their best week in and week out. Failing to make the most of this recovery period may result in free radical damage and delayed onset muscle soreness (DOMS). To maximize the benefits, it's important to prioritize food as the primary source of vital nutrients, while also recognizing the significant role supplements can play in providing the necessary building blocks for muscle repair due to their rapid absorption rate. However, it's essential to ensure that any chosen supplements are clinically validated, demonstrating efficacy and supported by solid scientific evidence. In today's fast-paced world, there is a growing demand for quick and convenient solutions to jumpstart the recovery process. Nevertheless, when it comes to choosing supplements, it's important to remember that one size does not fit all. The market offers an overwhelming array of options, often leaving individuals feeling bewildered about which products to select. Before diving into my recommendations for the top six supplements to aid in recovery, I believe it's crucial to emphasize the significance of cellular renewal and its direct impact on the recovery process. This, in my opinion, serves as the key to achieving a quick and effective recovery. Oxidation and Free Radical DamageA fundamental key to staying young and maintaining optimal health is cellular renewal and minimizing the damage to cells over time. We all age, but studies have shown that some individuals age better than others. Have you ever wondered why? Well, recent research has linked oxidative stress to the aging process. So, what exactly is oxidative stress? Allow me to explain in simple terms – oxidation occurs when the body produces by-products commonly known as free radicals. It's almost like a machine rusting, but instead of rust forming on iron, our bodies experience the effects of aging and age-related diseases. Now, our bodies naturally produce free radicals as part of our daily metabolism, and they can also be produced as a result of environmental pollutants from everyday things like air, water, and even sun exposure. As we age, our bodies become more vulnerable to the long-term effects of oxidative stress, which simply means we accumulate too many free radicals and experience increased inflammation at the cellular level. As interesting as it may sound, the process of oxidation is actually abundant and can be beneficial for our bodies to function properly. But, and this is an important "but," this very process can also cause potential harm. You see, the oxidizing process creates these molecules called free radicals, which are electrically charged. These free radicals interact with our cells, and this interaction can lead to both positive and negative outcomes. For example, our immune system utilizes free radicals to help fight infection. However, when LDL cholesterol (often referred to as bad cholesterol) is oxidized, it can become a concern (cholesterol buildup). Let's talk about oxidative stress. It occurs when the level of free radicals overwhelms the body's natural antioxidant defense system, resulting in cell damage. As I mentioned earlier, while free radicals serve useful functions in the body, they are highly unstable molecules. If they remain uncontrolled, they have the potential to wreak havoc by causing damage to cells, enzymes, and even our DNA, which ultimately accelerates the aging process. In addition, these free radicals can also contribute to the development of various age-related diseases, including arthritis, cancer, and heart disease Now, inflammation is triggered by free radical damage, and it is this inflammation that leads to the negative effects of free radicals due to oxidation. The question then becomes, how can we address this in our daily nutritional regimen? The answer lies in the incorporation of antioxidants, which play a vital role in combating oxidative stress and minimizing the damage caused by free radicals in our bodies. You'll be glad to know that there are foods rich in antioxidant content that can help us on this journey. In fact, certain foods contain phytonutrients that, according to many health professionals, hold the potential to unlock the secrets of longevity and overall well-being. So, my dear friend, let's take a proactive approach, nourish our bodies with antioxidant-rich foods, and strive to minimize the effects of oxidative stress caused by free radicals. It's never too late to make positive choices for our health and age gracefully. Phytonutrients, also known as health boosters, are substances produced by plants to protect themselves from harmful bacteria and viruses. However, these compounds also offer significant benefits to the human body. Packed with essential nutrients, phytonutrients play an active role in promoting good health. They belong to the antioxidant family, responsible for eliminating harmful free radicals and thus slowing down the aging process. Incorporating a diet rich in high antioxidant foods like fresh fruits and vegetables is crucial as the first line of defense against aging. While vitamins A, C, and E are commonly known antioxidants, there are other antioxidants available in both food and supplement form. These antioxidant supplements play a vital role in bridging the nutritional gap left by processed foods, lacking the necessary antioxidants and nutrients to combat free radicals effectively. Let's take a closer look at my top six supplement recommendations, known for their efficacy in fighting oxidative stress and promoting optimal recovery: Beta Alanine: As an amino acid derivative, Beta Alanine is proven to enhance intramuscular carnosine content, improving the body's ability to buffer hydrogen ions. During exercise, the body accumulates hydrogen ions, contributing to fatigue and lowering pH levels. Beta Alanine supplementation can reduce fatigue, enhance exercise performance, and increase training volume. Whether it's interval training or weightlifting to improve running economy, incorporating beta-alanine can have a positive impact on endurance performance and overall training results. BCAAs: Branched Chain Amino Acids (BCAAs) have become a staple supplement for athletes due to their role in muscle and energy production during exercise. Consisting of three essential amino acids - leucine, isoleucine, and valine - BCAAs have been shown to significantly reduce muscle soreness and expedite the recovery process. Supplementing with BCAAs helps prevent muscle breakdown, as the body does not need to rely on its own muscle tissue for energy. Consequently, protein synthesis remains high, supporting muscle growth and repair. Creatine, a natural molecule found in muscle cells. When engaging in high-intensity workouts like weightlifting, Creatine helps your body produce adenosine triphosphate (ATP), a vital energy source. This amazing compound improves strength, boosts lean muscle mass, and aids in faster muscle recovery. Flavonoid Root, a breakthrough extract known for its cardiovascular benefits. This extract is packed with potent antioxidants and acts as a nitric oxide booster, promoting increased endurance during workouts. Studies have shown that it fights against free radical damage and increases the flow of oxygen-rich blood, ensuring optimal cardiovascular health. You can also boost nitric oxide with beet root, and l-citruline. Speaking of studies, a published research paper in Food and Nutrition Research (April 2016) highlighted the effects of the unique flavonoid root extract on arterial health. The study revealed that after one year of consumption, participants experienced a decrease in artery wall thickness, total cholesterol, LDL levels, and blood pressure. This indicates that the extract may help reduce the risk of oxidation-related cerebral vascular issues and improve overall cardiovascular health Glutamine. It's the most abundant amino acid in the human body and plays a vital role in muscle recovery and repair. Glutamine aids in preventing muscle soreness, optimizing post-workout recovery, and supporting muscle rebuilding. By facilitating nitrogen transport, regulating acid-base balance, and acting as an antioxidant, Glutamine ensures faster post-workout muscle recovery, giving you the freedom to train harder for better results. Protein plays a crucial role in replenishing and repairing your muscles after a workout, making it a key nutrient to consume alongside carbohydrates. By opting for a protein shake as a post-workout option, you can efficiently supply amino acids to your muscles, stimulating muscle protein synthesis, enhancing recovery, and promoting growth. It's important, though, to choose a protein shake that contains high-quality ingredients, as prioritizing quality over quantity is key when it comes to protein. Apart from protein, there are several other supplements that work through various mechanisms to provide natural, broad-spectrum antioxidant and nutrient support, ultimately contributing to optimal health and recovery. Taking preventative measures to protect the health of different body systems is much easier than trying to restore their function after damage has occurred. With this in mind, retailers should suggest a preventive program to their customers, aiming to limit free radical damage and promote recovery. As the adage goes, "an ounce of prevention is worth a pound of cure," emphasizing the significance of protecting and preserving one's health. In conclusion, the role of antioxidants, particularly phytonutrients, in maintaining overall health and combating oxidative stress cannot be overstated. These beneficial compounds not only slow down the aging process, but also enhance the body's ability to recover from physical exertion. Various supplements, including Beta Alanine, BCAAs, Creatine, Flavonoid Root, Glutamine, and Protein, each offer distinct benefits in supporting muscle growth, improving athletic performance, and promoting quicker recovery. The incorporation of these supplements into one's regimen can effectively bridge the nutritional gap left by processed foods. A preventive strategy, emphasizing a diet rich in antioxidants and high-quality supplements, holds the key to optimal health and longevity. As the saying goes, 'an ounce of prevention is worth a pound of cure'.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6591) Curamin with VectOmega: The Ultimate Combination for Pain Relief
Date:
November 23, 2022 04:23 PM
If you're living with chronic pain, you know how debilitating it can be. It's hard to focus on anything else when your body is constantly in pain. Fortunately, there are ways to manage the pain and make it more bearable. One of the most effective methods is combining Curamin with Vectomega, a special fish oil that can help bring more pain relief than ever before. Let's take a look at why this combination works so well together. Curamin is an all-natural supplement made from the root of turmeric, which has been used for centuries for its natural anti-inflammatory properties. When taken regularly, Curamin helps reduce inflammation and pain in your body. That means less stiffness and discomfort throughout the day—and improved mobility. But while Curamin can help reduce inflammation, it doesn't work as quickly as some people need it to. That's where Vectomega comes in. This special fish oil is processed with an enzyme to extract the omega-3 from fish oil, leaving it in a peptide form that makes it more absorbable and more effective as a pain reliever than regular fish oil supplements. When combined with Curamin, Vectomega helps provide faster relief from inflammation and pain than either one alone would provide—so if you're looking for rapid relief from your chronic pain symptoms, this combination could be just what you need. Vectomega also offers other benefits beyond pain relief; studies have shown that taking omega-3s can help boost your immune system, reduce cholesterol levels, improve mental clarity and concentration, and even improve skin health by providing essential vitamins and minerals that your skin needs to stay healthy and radiant. By combining Curamin with Vectomega, you get the best of both worlds—rapid pain relief plus long-term health benefits like improved immunity and skin health. So if you're looking for an all-natural way to manage your chronic pain symptoms without relying on medication or surgery, this combination might be just what you need to get back on track. Recommended dosages: 3 x Curamin daily, 3 x VectOmega daily. till pain is reduced then you can back down on the VectOmega. Don't take our word for it, Give it a try today! If you don't feel it helped, We will Pay to Bring the Product back and Refund 100% of the purchase.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6569) Gymnema Sylvestre - An Herb That Promotes Healthy Glucose Metabolism
Date:
October 25, 2022 02:41 PM
Gymnema sylvestre is an herb that has been used traditionally in India for centuries. Modern research has shown that this herb may help to support healthy glucose metabolism through its ability to promote healthy pancreatic function.* In addition, gymnema exhibits potent free-radical scavenging properties.* NOW® Gymnema Sylvestre Extract is standardized to gymnemic acids, which are the compounds that have been identified as its bioactive constituents.* Gymnema sylvestre is a woody climbing shrub that grows in the tropical forests of central and southern India. The leaves of the plant have been used traditionally in Ayurvedic medicine for centuries.1 Modern science has validated many of the traditional uses for this herb and has identified several key active components.2-4 Promotes Healthy Pancreatic Function* One of the traditional uses for Gymnema sylvestre was to support healthy glucose metabolism.5 This effect was thought to be due to the herb’s ability to promote healthy pancreatic function.* The primary active components in Gymnema sylvestre – gymnemic acids – have been shown in animal studies to increase insulin secretion from the pancreas.6,7 In addition, these compounds appear to help maintain healthy beta cell function and architecture.8,9 Maintenance of normal beta cell function is critical for long-term metabolic health since these cells are responsible for producing insulin in response to rising blood sugar levels.10,11 Exhibits Potent Free-Radical Scavenging Properties* In addition to supporting healthy pancreatic function, recent research has shown that Gymnema sylvestre extracts also possess potent free-radical scavenging properties.*12 These effects were attributed primarily to the gymnemic acids present in the herb.13 This natural free-radical scavenging activity may help support cellular health.* NOW® Gymnema Sylvestre Extract is standardized to a minimum of 25% gymnemic acids and provides 6:1 extract potency. For easy supplementation, take 2 capsules 1 or 2 times daily with food or water. In Summary: Gymnema sylvestre is an herb with a long history of use in Ayurvedic medicine. Modern science has validated many of the traditional uses for this herb and has identified several key active components, including gymnemic acids which have been shown in animal studies to increase insulin secretion from the pancreas. Additionally, extracts of Gymnema sylvestre have been shown to possess potent free-radical scavenging properties which may help support cellular health.* NOW® Gymnema Sylvestre Extract is standardized to a minimum of 25% gymnemic acids and provides 6:1 extract potency. For easy supplementation, take 2 capsules 1 or 2 times daily with food or water.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6523) The Consequences of Not Getting Enough Sleep
Date:
September 14, 2022 04:03 PM
Most people know they should be getting around eight hours of sleep per night, but according to the National Sleep Foundation, between 50 and 70 million U.S. adults havea sleep disorder*. That means many of us are not getting the quality sleep we need on a nightly basis. But what does that mean for our health? Let’s take a look. Short-Term Effects of Sleep Deprivation There are many short-term effects of not getting enough sleep, including: * Difficulty concentrating or making decisions * Increased forgetfulness * Moodiness or irritability * Slow reflexes * Increased anxiety * Decreased sex drive * Weight gain or weight loss * Heightened senses * Increased susceptibility to colds and flus Long-Term Effects of Sleep Deprivation The long-term effects of sleep deprivation are even more concerning. Some of the long-term effects of not getting enough sleep include: * High blood pressure * Diabetes * Heart disease * Mood disorders such as depression or anxiety * Memory problems * weakened immune system * Increased pain perception Conclusion: As you can see, there are many short-term and long-term effects of not getting enough sleep. If you think you might have a sleep disorder, talk to your doctor about treatment options. In the meantime, practice good sleep hygiene by avoiding caffeine before bedtime, establish a regular sleep schedule, and create a calming bedtime routine. Do your best to get seven to eight hours of quality sleep every night so you can wake up feeling refreshed and ready to take on the day! Need more sleep try melatonin! What is Melatonin? Melatonin is a hormone that helps regulate our sleep-wake cycles. It's produced naturally by our bodies in response to darkness and starts to increase in the evening as we prepare for bed. How Does Melatonin Work? Many people take melatonin supplements in an effort to improve their sleep quality. And there is some evidence to suggest that it can be helpful. One small study found that melatonin supplements helped people fall asleep faster than placebo pills did. However, the effects were only temporary, lasting for just three days. Another study looked at the effects of melatonin on people with insomnia due to jet lag. This research found that melatonin supplements shortened the time it took for participants to fall asleep by about an hour on average. It's important to note that these studies looked at short-term usage of melatonin supplements. There's not much research available on the long-term effects of taking this supplement. If you're struggling to get enough sleep, you might be wondering if supplements could help. One popular option is melatonin. But what is it, and does it really work? Melatonin is a hormone that helps regulate our sleep-wake cycles which is produced naturally by our bodies in response to darkness.. Many people take melatonin supplements in an effort to improve their sleep quality and there is some evidence to suggest that it can be helpful such as one small study found that melatonin supplements helped people fall asleep faster than placebo pills did.. however the effects were only temporary lasting three days or another study which looked at the effects of melatonin on people with insomnia due to jet lag and found that it shortened the time it took participants to fall asleep by an hour on average... Give Melatonin a try and sleep better!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6451) Cortisol and Adrenal Balancing Supplements: How to Reduce Cortisol and Fight the Effects of Stress
Date:
May 07, 2022 11:38 AM
Do you feel like stress is constantly wearing you down? It's no wonder, with all the demands on our time and energy. The good news is that there are steps you can take to reduce cortisol and improve your resilience. One of the most important is to make sure you're getting enough of the nutrients your body needs to stay strong. A cortisol balancing supplement can help make up for any deficiencies and give your body the support it needs to reduce cortisol levels and fight the effects of stress. If you can balance cortisol levels you will have more energy & stamina, be able to manage weight better, boost immunity, support hormone activity, manage blood sugar better, reduce stress and improve mood. The problem of cortisol imbalance and its effects on the body The hormone cortisol is important for many bodily functions, including maintaining blood pressure and regulating metabolism. However, when the body experiences chronic stress, it can produce too much cortisol, leading to a condition known as "cortisol imbalance." Cortisol imbalance can have a number of harmful effects, including weight gain, anxiety, and depression. In extreme cases, it can even lead to adrenal fatigue. Unfortunately, cortisol imbalance is becoming increasingly common in our fast-paced, high-stress world. If you are concerned that you may be suffering from this condition, a supplement formulated to combat stress and high cortisol levels my be what you need. With proper nutrients, it is possible to restore balance to your hormones and improve your overall health. The importance of nutrients in maintaining a healthy balance of cortisol A healthy diet is important for many reasons. It can provide the body with the nutrients it needs to function properly, help to regulate hormone levels, and promote a sense of well-being. Cortisol is a hormone that plays an important role in the body's stress response. When levels of cortisol are too high, it can lead to anxiety, irritability, and difficulty sleeping. Eating foods that are rich in nutrients such as vitamin C, Vitamin B1, B2, B6, B12, Folate, Biotin, pantothenic acid, and DHEA can help to maintain a healthy balance of cortisol in the body. In addition, avoiding processed foods and managing stress levels with exercise can also help to keep cortisol levels in check. Adrenal fatigue Stress is a natural physical and mental response to the demands of life. It is the body's way of preparing to meet a challenge. However, when a person experiences chronic or long-term stress, it can take a toll on their health. Long-term stress can lead to a condition known as adrenal fatigue. This occurs when the adrenal glands become unable to produce adequate amounts of the hormone adrenaline. Cortisol is essential for managing stress and maintaining proper metabolism. When levels are too low, it can cause a variety of symptoms, including fatigue, difficulty concentrating, and difficulty sleeping. In severe cases, adrenal fatigue can also cause depression and anxiety. Adrenal Fatigue and Adrenaplex The adrenal glands are small, but they play a big role in our bodies. When the adrenal glands become fatigued, it can lead to a number of symptoms, including fatigue, trouble sleeping, mood swings, and low blood pressure. While adrenal fatigue is not a diagnosable condition, it is a real phenomenon that can be treated with lifestyle changes and natural supplements. Adrenaplex is one such supplement. This formula contains adaptogenic herbs that help to support the adrenal glands and improve their ability to respond to stress. When Cortisol levels Are balanced You Will Experience:
Though it is possible to treat adrenal fatigue with a cortisol balancing supplement, the best way to prevent it from happening in the first place is by managing stress levels and eating a healthy diet. If you are under a lot of stress, consider adding an adrenal support supplement to your routine. This can help to improve your body's response to stress and keep your hormones in balance. If you are looking for a way to reduce cortisol and the effects of stress, try a cortisol balancing supplement. These supplements help the body reduce cortisol and fight the effects of stress. With proper nutrients, it is possible to restore balance to your hormones and improve your overall health. Try a cortisol balancing supplement today! You may be surprised at how much better you will sleep, wake in the morning, and feel overall!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6406) Are We Headed Towards a Food Shortage in America? : Essential Vitamins, Minerals, and Protein Powders to Maintain Good Health
Date:
May 07, 2022 09:33 AM
What is a food shortage, and why are we headed towards one in America? A food shortage is a period of time where there is not enough food to meet the demand of the people within a certain region. This can be caused by a number of factors, including natural disasters, war, and economic downturns. In America, we are currently facing a perfect storm of conditions that could lead to widespread food shortages in the coming years. Climate change is resulting in more extreme weather patterns that damage crops, while at the same time, the population is continuing to grow. In addition, many Americans are struggling with financial instability, which makes it difficult to afford healthy food. As a result, we are heading towards a time where there may not be enough food to go around. It is important for everyone to be aware of this issue and take steps to reduce their impact on the problem. One way to do this is to reduce food waste, which will help to stretch our limited resources further. We can also support local farmers and producers who are working hard to ensure that everyone has enough to eat. By taking action now, we can help to prevent a future food shortage from becoming a reality. The importance of having essential vitamins, minerals, and protein powders It is essential for the body to have vitamins, minerals, and protein to survive. The body needs these essential nutrients to function properly. Vitamins help the body to produce energy, regulate metabolism, and maintain healthy tissues. Minerals are needed for the proper development and function of the skeletal system and muscles. Protein powders provide the building blocks for the growth and repair of tissues. Without these essential nutrients, the body would not be able to perform its basic functions. As a result, it is essential that people get enough of these nutrients through their diet or supplements. The benefits of taking supplements during a food shortage One of the most common questions people ask during a food shortage is whether or not they should take supplements. While there are benefits to taking supplements, it's important to understand that they should never be used as a replacement for real food. Instead, supplements should be viewed as a way to fill in the gaps when you're not getting all the nutrients you need from your diet. For example, if you're not getting enough vitamin C from the fruits and vegetables you're eating, taking a supplement can help ensure that your body gets the Vitamin C it needs. While supplements can't take the place of a healthy diet, they can be a helpful way to make sure you're getting all the nutrients your body needs during a food shortage. How to store your supplements for long-term use Supplements are an important part of many people's health regimens. If you want to make sure your supplements last as long as possible, there are a few things you need to do. First, always store your supplements in a cool, dry place. Heat and humidity can cause vitamins and minerals to break down, so avoid storing them in the bathroom or kitchen. Second, keep them out of direct sunlight. Ultraviolet light can also degrade vitamins and minerals, so it's best to keep supplements in a dark closet or cabinet. Finally, make sure the bottles are tightly sealed. Exposure to air can cause supplements to lose their potency, so it's important to keep them well-protected. Supplements generally have expiration dates of 2 - 3 years out, and are still good beyond the best used by date on the bottom of the bottles. FAQs about food shortages and supplements Q: What are the causes of food shortages? A: Food shortages can be caused by a variety of factors, including natural disasters, war, economic instability, war and climate change. Q: What are the effects of food shortages? A: The effects of food shortages can be devastating. People may go hungry or face malnutrition, which can lead to health problems and death. Children are often the most affected by food shortages, as they need adequate nutrition to grow and develop properly. Families may also lose their livelihoods if they can't afford to buy food, which can result in poverty and homelessness Q: What can I do to prevent a food shortage? A: There are a number of things people can do to prevent a food shortage. Some of the most important include:
Q: What should I do if there is a food shortage? A: If there is a food shortage, the best thing to do is to stay calm and ration the food you have. Try to eat a balanced diet of fruits, vegetables, grains, and protein. Don't forget to include essential vitamins and minerals in your diet. You can also try growing your own food or raising your own livestock, If you have to. Store up Food if you see empty shelves at the grocery store. Q: Are supplements necessary during a food shortage? A: While supplements can't take the place of a healthy diet, they can be a helpful way to make sure you're getting all the nutrients your body needs during a food shortage. Q: How can I store my supplements for long-term use? A: There are a few things you need to do to keep your supplements safe and effective for long-term use. First, always store them in a cool, dry place. Heat and humidity can cause vitamins and minerals to break down, so avoid storing them in the bathroom or kitchen. Second, keep them out of direct sunlight. Ultraviolet light can also degrade vitamins and minerals, so it's best to keep supplements in a dark closet or cabinet. Finally, make sure the bottles are tightly sealed. Exposure to air can cause supplements to lose their potency, so it's important to keep them well-protected. Supplements generally have expiration dates of two to three years out, and are still good beyond the expiration date.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6405) Reduce the effects of chemotherapy with safflower seeds
Date:
May 08, 2019 04:35 PM
Chemotherapy which is often shortened to chemo is the use of drugs to eliminate and reduce cancer cells. Because of its systemic effects and ability to kill cancer cells despite the site they are found, it has been widely used in conventional medicine and oncology to fight cancer. But the treatment is not without risks since it can include long term damage to sensitive organs in the body like the lungs, heart, and kidneys. A recent study that was published in the American Journal of Chinese Medicine took a look at the effect of chemotherapy on the kidneys. They studied the effectiveness of safflower seeds against the side effects of cisplatin, a chemotherapy drug used against cancer. They used animal models and compared the effect on damages to the kidneys. Cisplatin is not only used to treat cancer, it is used to prevent the spread of cancer to other parts of the body. It has some side effects which include nausea, vomiting, hair loss, dry skin, and hiccups. It is advisable that pregnant women and breastfeeding women not take it because it can harm the baby. When safflower seeds effect were studied, there were remarkable results discovered leading to the conclusion that safflower seeds were effective in reducing the effects of renal damage caused by cisplatin. Key Takeaways:
"The treatment, despite being touted as “effective against many forms of cancer,” isn’t without risk, which can include both acute and long-term damage to organs like the lungs, heart, nerves, and kidneys." Read more: https://www.naturalnews.com/2019-04-17-reduce-the-effects-of-chemotherapy-with-safflower-seeds.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6288) What is liver cirrhosis? (and is alcohol always the cause of it?)
Date:
May 02, 2019 11:59 AM
Cirrhosis is the advanced scarring of liver tissue. When the liver is injured, it will try repair itself, but this can lead to scarring (a.k.a. fibrosis). Advanced levels of scarring is cirrhosis. Excess drinking is a common cause of liver cirrhosis, but it isn't the only cause. A condition known as Nonalcoholic Fatty Liver Disease (NAFLD), actually the most common cause of liver disease in the U.S., can also lead to the disease. People who are overweight are at risk for NAFLD, so maintaining healthy weight is one way to prevent cirrhosis. Avoiding excess alcohol consumption is another. Finally, eating plenty of green leafy vegetables can protect the liver from damage. Key Takeaways:
"Each time that the liver is injured — whether by disease, excessive alcohol consumption, or fat cells that become toxins — it will try to repair itself." Read more: https://www.naturalnews.com/2019-03-26-what-is-liver-cirrhosis-and-is-alcohol-always-the-cause-of-it.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6235) 4 magical herbs that can help you lose weight faster
Date:
April 26, 2019 01:34 PM
We're constantly met with over-the-counter supplements loaded with chemicals and preservatives that promote claims of being able to shrink your waistline, but what if there were more natural options? Consuming ginseng helps regulate your blood sugar levels, as well as boost your metabolism. Garlic is almost a magical herb in how it is able to help you fight off cravings due to your body being able to sustain levels of fullness for longer periods of time. Key Takeaways:
"Those 7 days or 1-month weight loss challenges cannot give you a long-term result." Read more: https://timesofindia.indiatimes.com/life-style/food-news/heres-4-magical-herbs-that-can-help-you-lose-weight-faster/articleshow/68283825.cms
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6191) Study looks at anti-diabetes properties of a barberry plant nativeto Africa
Date:
April 09, 2019 10:19 AM
Type 2 diabetes is a major health concern, but the drugs healthcare professionals currently turn to are expensive and have negative side effects. As an alternative, researchers in Kenya have found that the spiny evergreen shrub Berberis holstii has anti-diabetic properties. It is traditionally used as a medicine against a wide variety of ailments. The researchers found that, in rats, the plant could reduce blood glucose level. Berberis holstii isn't the only alternative substance that has anti-diabetic properties, other plants/foods include fatty fish, leafy greens, cinnamon, eggs, chia seeds, and turmeric. Key Takeaways:
"This spice reduces hemoglobin A1c, a marker of long-term blood sugar levels. It is also known to reduce cholesterol and triglyceride levels." Read more: https://www.naturalnews.com/2019-02-06-study-looks-at-anti-diabetes-properties-of-barberry-plant.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6123) New study links negative mood with higher levels of inflammation
Date:
January 05, 2019 02:26 PM
New research from Penn State University has shown that being in a negative mood can be linked with higher levels of inflammation and may be a signal of poor health. Inflammation is a contributing factor to many diseases such as diabetes and cancer. These negative emotions include sadness, anger, and depression. 220 participants reported on their moods and blood samples were taken to measure the inflammation present in the body. This was the first study to research how the two are linked. The long-term goal of the researchers is that the information will eventually lead to insights into how interventions can improve mood and ability to cope with stress. That will in turn help break the cycle of disease associated with inflammation. Key Takeaways:
"New US research has found that a negative mood, such as feeling sad or angry, may be linked with higher levels of inflammation and may be a sign of poor health." Read more: https://www.malaymail.com/s/1705392/new-study-links-negative-mood-with-higher-levels-of-inflammation
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5935) Vitamins for Brain Function
Date:
September 12, 2018 09:52 AM
Your brain needs good nutrition to be at its best. Vitamin B6 and folate play important roles in neurological and psychological health. The Omega-3 fatty acids DHA and EPA also have vital roles to play, and can be found in seafood, flaxseed and fish and krill oil supplements. B Complex vitamins are constantly used up by the nervous system and must be regularly replenished. Stress and alcohol consumption both increase the depletion rate of B vitamins. Iron and various different minerals also play their own vital roles. Key Takeaways:
"The human brain needs the correct nutrition through all stages of life, just like any other part of the body." Read more: https://www.news-medical.net/whitepaper/20180907/Vitamins-for-Brain-Function.aspx
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5760) Borage seed oil found to mitigate effects of radiation therapy on the liver
Date:
August 19, 2018 09:53 AM
Borage seed oil is typically used to treat the following health problems, rheumatoid arthritis, chest congestion, cough, depression, premenstrual syndrome, and menopausal symptoms. It is often used for hair and skin conditions such as hair loss, eczema, and Acne. borage oil contains a powerful anti-inflammatory compound known as gamma-linolenic acid however, borage oil is unique in that its GLA content is remarkably high.Also known as starflower, borage (Borago officinalis) is an herbaceous flowering plant.As a common herbal treatment in traditional medicine practices for hundreds of years, borage oil has numerous uses ranging from treating skin flare-ups to lowering pain.The most beneficial aspect of using borage oil either topically on the skin or internally in capsule form is it has strong anti-inflammatory effects.Borage oil is becoming increasingly popular as a natural anti-inflammatory supplement because it has one of the highest amounts of GLA of all seed oils.GLA is one type of omega-6 “essential” fatty acid that the body cannot make on its own, so we must get it from outside sources.The mechanisms of [borage oil] that provide protection against gamma-irradiation-induced toxicity may be explained by its antioxidant activity, inhibition of MDA, and prevention against GSH depletion due to its high content of GLA. Therefore, [borage oil] may be used as a beneficial supplement for patients during radiotherapy treatment.Borage can be helpful for treating a wide range of both short- and long-term illnesses like Bone loss and osteoporosis,skin disorders,Rheumatoid arthritis pain,managing diabetes,Dealing with stress, Hormonal imbalances, including adrenal insufficiency,respitory distress like bronchitis, colds, coughs and fevers,Alcoholism,preventing heart diseases and Inflammation causing pain and swelling. Borage oil is often used along with evening primrose oil supplements to further increase the anti-inflammatory and pain-reducing effects. Key Takeaways:
"Also known as starflower, borage (Borago officinalis) is an herbaceous flowering plant most known for being the source of borage oil." Read more: https://www.naturalnews.com/2018-08-17-borage-seed-oil-found-to-mitigate-effects-of-cancer-treatment-the-supplements-antioxidant-activity-reduces-damage-to-liver-from-chemicals-according-to-study.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5713) Eating more fennel keeps your heart healthy â?? especially when consumed regularly
Date:
July 07, 2018 09:54 AM
If you want to lower your chances of getting cardiovascular disease, exercise will go a long way toward helping you reach that admirable goal. In fact, an active exercise routine can lower hypertension and also other chemicals in your body that are responsible for many chronic conditions, like diabetes. However, for a small few, exercise won't significantly help them fight it so many are turning to fennel for its many benefits including its lowering of antihypertensive in people. Key Takeaways:
"For this study, the researchers trained their eyes on the fennel or Nigella sativa (NS)." Read more: https://www.naturalnews.com/2018-07-05-eating-more-fennel-keeps-your-heart-healthy-especially-if-you-take-them-regularly.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5657) Dissolves plaque in your arteries, drink it daily
Date:
June 22, 2018 11:54 AM
High quality teas, such as green tea, can help with anti-aging and reducing plaque in your arteries, in your heart and brain. Polyphenols account for this, the strongest being EGCG. Because of these compounds, tea helps to lower blood pressure and protect your heart. Green tea provided the best results. The ideal number of cups to drink is four per day. Other benefits of tea include lowered cancer risk, weight loss, lowered risk of type 2 diabetes, reduced pain and inflammation associated with RA, and protection against eye diseases, and genital and anal warts, to name a few. Key Takeaways:
"Previous research has shown long-term tea intake can improve your blood pressure readings." Read more: https://www.healthnutnews.com/dissolves-plaque-in-your-arteries-drink-it-daily/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5641) Prevent vision loss by protecting your heart with a healthy diet
Date:
May 03, 2018 09:17 AM
The amount of those suffering from eyesight across our nation is expected to reach over a staggering 22 million by the year 2050. Many physicians are now recommending that their patients adhere to healthier diets in order for the odds to be in their favor when it comes to keeping their eyesight long-term. It is important to eat healthy foods due to them being high in antioxidants which can help fight harmful bacteria in our body that can lead to disorders that cause vision loss. Key Takeaways:
"Joshi’s colleague, Dr. Nancy Kunjukunju, M.D. gets even more specific. She states that a heart-healthy diet and lifestyle are essential for those who are afraid of getting AMD because the disease runs in the family." Read more: https://www.naturalnews.com/2018-05-01-prevent-vision-loss-by-protecting-your-heart-with-a-healthy-diet.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5591) Diabetes could lead to dementia: Prevent memory loss and high blood sugar - but how?
Date:
January 31, 2018 03:59 PM
Taking control of your diet, specifically your blood sugar, has been known for a long time as a key to long term health. It can help regular your chance for stroke, heart disease and diabetes, but regulating your blood sugar may also help with stopping dementia according to recent research. Focusing on what you take in will be key as you get older. Stick with whole grains and vegetables, and stay away from heavy starches and sugars to help your body maintain itself long into life. Key Takeaways:
"DIABETES patients in old age are more likely to suffer from long-term deterioration in their memory and thinking skills than those who have normal blood sugar levels, according to a new study." Read more: https://www.express.co.uk/life-style/health/911522/diabetes-dementia-symptoms-signs-test
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5518) Ibuprofen found to RAVAGE male fertility and threaten testicular health: Just 3 tablets per day can result in lower libido, muscle loss, depression, and eventually ED
Date:
January 17, 2018 07:59 AM
Researchers in France and Denmark have uncovered a negative effect from the long-term use of ibuprofen. Ibuprofen causes fertility problems in men because it reduces the amount of free testosterone, a condition otherwise known as hypogonadism, also called low testosterone or "Low-T". The men in the study were between the ages of 18 and 35 and were given two 600 mg doses of ibuprofen a day. This dose is commonly taken by athletes and by people who are pain management patients. The researchers concluded that the risk to men of taking ibuprofen long-term is greater than the benefit. Men should use caution and think twice before taking ibuprofen. Key Takeaways:
"This new research is built on the team’s earlier work, wherein they found that over-the-counter pain relievers could affect the testicles of male babies." Read more: https://www.naturalnews.com/2018-01-14-ibuprofen-found-to-ravage-male-fertility-and-threaten-testicular-health.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5491) Artificial sweeteners may increase risk of diabetes in two weeks, study claims
Date:
December 31, 2017 11:59 AM
A new study out of Australia has shown that in as little as two weeks, using no calorie sugar substitutes can actually increase your risk for type 2 diabetes. These sweeteners can actually increase your glucose tolerance, causing weight gain and high blood sugar levels in your system. This is a concern that affects both diabetics who use them to avoid ingesting sugar as well as those without diabetes who can become sick using them. Key Takeaways:
"Artificial sweeteners could potentially increase the risk of developing type 2 diabetes (T2DM) in two weeks, says research that fuels ongoing debate over the sugar substitutes’ long-term health effects." Read more: http://www.foodnavigator.com/Science/Artificial-sweeteners-may-increase-risk-of-diabetes-in-two-weeks-study-claims
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5467) 6 vitamins that boost hair growth and prevent hair loss - Atlanta Journal Constitution
Date:
September 29, 2017 01:14 PM
6 vitamins have shown evidence of being able to prevent hair loss. Vitamin C works by improving the production of collagen thus supporting healthier hair. B5 and Vitamin A are also helpful as B5 can help with your hair shafts and Vitamin A with the folicle. Vitamin H (biotin)also helps support the hair folicles. And lastly, iron- because lack of iron can increase hair loss. Your whole body will benefit when you ensure you get enough of these nutrients- not just your hair! So, you have "nothing to lose!" Key Takeaways:
"Take steps to prevent hair loss and improve hair growth from the inside out by adding certain vitamins and minerals to your diet." Read more: http://www.ajc.com/business/vitamins-that-boost-hair-growth-and-prevent-hair-loss/qWz6etwrsHSxbRGvCutdSP/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5292) Apple, Beet and Carrot Juice Liver Tonic
Date:
August 30, 2017 09:14 AM
Your liver is a very important organ in your body. It serves to clean all of the toxins out of your body. In today's world, people are not eating enough cleansing foods to keep their livers fully functioning and it is visible on the outside of their bodies and the instance of liver cancer is increasing. To be healthier, a mix of apple, beets, and carrots- preferably organic- with some lime and ginger- is recommended. Key Takeaways:
"You may end up liking it so much that you want to have it long-term and see just what it can do to improve your liver’s function and by association your appearance, general immunity and ultimately your overall health." Read more: https://www.healthambition.com/apple-beet-carrot-juice-liver-tonic/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5195) 4 Foods to Keep High Blood Pressure in Check and Prevent Heart Disease Risk
Date:
August 25, 2017 04:14 PM
High blood pressure is not something to take lightly. It can lead to stroke and heart problems if it is prolonged. There is medicine you can take but there is also a dietary way to help lower it. This talks about four foods you can eat to help you get there. Changing your diet is often a good way to control your health since putting good things into your body will help you to get good out of it. Key Takeaways:
"This study highlights the need for long-term follow-up of women with a history of hypertension during pregnancy to provide early management of risk factors for cardiovascular disease" Read more: http://www.ndtv.com/food/4-foods-to-keep-high-blood-pressure-in-check-and-prevent-heart-disease-risk-1739973
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5177) A Non-Diet Approach to a Healthy Breakfast
Date:
July 31, 2017 12:14 PM
Breakfast is important. It gives you the energy you need to start the day. It should be balanced and should contain the right mix of foods. This gives advice on creating one which is healthy. You don't have to diet to eat a healthy one. You need only pay attention to the nutrients in your food. Dieting is often counterproductive since most aren't balanced enough, and they also tempt you to cheat since they are so prohibitive. https://www.youtube.com/watch?v=Zs4ioUho8Hk&rel=0Key Takeaways:
"Breakfast then becomes the natural starting point for any diet, meal plan, healthy eating vow, etc"
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5065) Phostphatidylyserine: Promotes Long Term Brain Health
Date:
June 13, 2017 11:14 AM
Phostphatidylyserine promotes long term brain health in people. It is a fatty compound heavily involved in the health of the cellular membranes. It keeps your brain cells healthy as you age. There are many benefits to it. It helps to lower stress as well. It can also help to boost your learning speed. It actually does this at an impressive rate. It is a really amazing thing and it can help out many people in the world. Read more: Phostphatidylyserine: Promotes Long Term Brain Health
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4824) Treat Your Arthritis Problems With Gelatin Amazing!!
Date:
June 04, 2017 05:14 AM
People who suffer with arthritis should consider the alternative and natural remedy of Gelatin. Gelatin is mostly know as an ingredient in candies and milk, but if used a teaspoon twice a day can considerably lower your pain level associated with arthritis. Gelatin has proteins made from animal cartilage bones and tendons. Most of the time we have gelatin in foods we would have never known. just by having this small amount 2 times a day can change the pain associated with arthritis in 4 to 6 weeks! https://www.youtube.com/watch?v=zum4zToUk4Q&rel=0Key Takeaways:
"Although there are medicines that reduce pain, these do not disappear forever."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4765) Nootropics: Brain Boosting Supplements
Date:
May 23, 2017 03:44 PM
Nootropics are a source of hope for those looking to hone their memory and brain power, but with them come some dissent as well. The FDA currently has no approval on such things so the benefits of using them have not been clinically based for approval by the organization. Although the hope is that these can be leveraged to improve memory power for those surrounding us, it's important to understand the true effects of their nature and making a determination for yourself based on the facts, not simply what you've heard. Key Takeaways:
"Regardless of motivation or experience, there is one common thread that connects the Nootropic experience for everyone—balance." Read more: http://www.einnews.com/pr_news/382056043/nootropics-brain-boosting-supplements
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4677) Keto Diet Food List, Including the Best vs. Worst Keto Foods
Date:
May 14, 2017 03:44 PM
Dieting is the practice of eating food in a regulated and supervised fashion to decrease, maintain, or increase body weight. In other words, it is conscious control or restriction of the diet. Many forms of dieting have existed for years. None is as effective as the Keto Diet though. It helps stimulate weight loss easy, prevents diabetes, and reduces your HDL cholesterol by eating simple vegetables and proteins. Your menu variety is high and portions are important. Key Takeaways:
"Unlike many fad diets that come and go with very limited rates of long-term success, the ketogenic diet has been practiced for more than nine decades (since the 1920s) and is based upon a solid understanding of physiology and nutrition science." Read more: https://draxe.com/keto-diet-food-list/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4615) fight heart disease with a plant-based, oil-free diet
Date:
April 24, 2017 11:44 AM
Diet has a lot to do with how your heart responds and functions. Many have looked at how a plant-based, oil-free diet work towards positive outcomes. It can be said that lowering saturated fats is very important, and there is a lot of evidence that the Mediterranean style diet, which emphasizes fish and poultry, along with fruits, vegetables and olive based oils, is a good way to go. Diets must provide good taste in order for people to stick to them long-term. The Mediterranean Diet seems to provide the health benefits and the taste in a much more positive way then the American Heart Association Diet. https://www.youtube.com/watch?v=yAQ40dVt8CM&rel=0Key Takeaways:
"Small studies suggest that this eating pattern can shrink the amount of cholesterol-clogged plaque in your arteries, the main culprit in cardiovascular disease."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4468) Eat This One Food To Get Rid Of Brain Fog
Date:
March 18, 2017 06:44 AM
Omega-3 fatty acids play an important role in our health including anti-inflammation, reducing the risk of chronic diseases, maintaining brain function. ALA, DHA and EPA are 3 types of omega-3s that are most beneficial to our brain such as effects on depressive conditions, post-stroke, neuropathic pain, migraines, neurodegenerative disease and improving cognitive performance. ALA comes from plants. DHA and EPA are found in fatty, cold-water fish and shellfish. A balance of sources from plants and seafood will help you to find the right balance of these essential fatty acids, which is fundamental to prevent inflammation. Make sure to consult with your healthcare provider to find out the amount that is best for your unique condition. Key Takeaways:
"A well-balanced diet with natural sources of ALA, DHA, and EPA is fundamental to maintaining a healthy ratio that prevents inflammation and promotes long-term health." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4199) Obesity could triple your risk of stomach cancer later in life
Date:
March 02, 2017 10:59 AM
A new report looking at what causes stomach cancer found three new somewhat surprising links: alcohol, processed meat and obesity. All three are linked with several other cancers, including colon cancer and breast cancer, but this is the first time they've been associated with stomach cancer. The report also finds more typical causes: smoking, eating food preserved with salt, and infection with a bacteria called Helicobacter pylori. Key Takeaways:
"Those who gained more than 45 pounds also faced twice the risk of developing esophageal cancer, compared to those who maintained a healthy weight." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4057) Testosterone Therapy May Have Benefits, But Risks Too
Date:
February 26, 2017 07:59 AM
Low testosterone can dim a man's sex drive, performance in bed, energy, and motivation. It can also have some harmful effects. When needed, testosterone replacement therapy can boost T levels back to normal and return him to the man he used to be. Still, there are also risks to TRT, and the long-term safety isn't clear. Here's what men need to know. Key Takeaways:
"All told, the Testosterone Trials seem to indicate that the best use of testosterone therapy is for treatment of decreased sexual function in men with so-called “low T” (low testosterone levels), said Dr. Thomas Gill." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4026) 20 Minute Body
Date:
February 15, 2017 07:59 AM
This book is easy to read, and mainly very easy to follow. The 20 minutes workout doesn't include the warm up, which will take you around 4-5 minutes. If you follow the 20 minutes workout as instructed, you will be sweating like crazy within 10 minutes, and your muscles will be store. Moves are easy to perform, nothing fancy or that requires reading the instructions over and over. Key Takeaways:
"This site can’t be reached couponlink1122.download60coaching.club’s server DNS address could not be found." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3945) Stress, heart health, and the amygdala: Links explained
Date:
January 22, 2017 12:59 PM
Though it is not clearly understood yet, studies show that psychological stress seems to have a connection with heart health, even including cardiac events and other major problems such as higher blood pressure, stroke, and angina. Higher levels of amygdala activity have been associated with increased risk of problems related to the heart, even when taking into account other risk factors. Key Takeaways:
"Long-term stress is linked to cardiovascular disease." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3815) Study Improving The Mother's Immune System
Date:
January 11, 2017 12:59 PM
Recently a new research study has found an essential function of a particular kind of immune cells found in mothers uterine line. These particular cells were B lymphocytes which were found to aid in the resistance of preterm births that are caused from inflammation. The researchers found that the cells create antibodies which aid in the defense against infection. Key Takeaways:
"While preterm birth — defined as a birth taking place before the 37th week of pregnancy — is a complex condition, there are two causes which the specialists identified to be responsible for it: infection of the mother and ensuing inflammation." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3768) Protein Can Stabilize Blood Sugar Levels
Date:
January 09, 2017 08:02 PM
Many people suffer from blood sugar level inconsistencies. A condition known as hypoglycemia is caused when your blood sugar (glucose) drops, resulting in a range of symptoms. Many people with diabetes suffer from hypoglycemia, and the common solution is thought by many to be a sweet treat. However, this can often exacerbate the problem. More often the solution is to give the person some foods which contain protein. How protein can stabilize blood sugar levelsIn much the same way that dietary fiber works, eating a source of high-quality protein along with your meals and snacks can have a beneficial effect on your body's blood sugar levels. Adding some protein to your meal would help to provide the amino acids for tissue repair and recovery while also ensuring you stay satisfied for several hours after eating or consuming the meal. By choosing the right combination of protein and carbohydrates to eat, you can control the amount of glucose in your bloodstream by slowing the process of digestion. This slowing down prevents a blood sugar spike as a result of overdosing on carbohydrates. However, this doesn't mean that you can just eat foods with protein to your content. Your body can only assimilate so much protein in a single sitting, so you need to be able to ration your intake. Too much protein included in your diet can have severe side effects like intestinal wind, bad breath, and indigestion and there are also long-term health concerns concerning a diet that's too rich in protein. Though many people might find it challenging to manage, diabetes is not a friendly condition you should just live with. Indeed, with simple changes in your life, you can reap great benefits such as weight reduction and lower both your blood sugar levels as well. Include foods rich in protein in your daily diet and the results will be amazing.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3762) Development of castor oil.
Date:
January 03, 2017 09:46 PM
There are about hundreds of castor oil factories in China, of which only about 10% castor oil manufacturers start working; large processing plants have around 20; only nine plants have tens of thousands processing capacity. About 70% of Chinese castor oil processing factories in stop production or semi-shutdown state, because there are no adequate, high-quality raw material castor sources. At the end of the 1980s, China extends and built several large scale castor oil factories, each factory's total amount of annual output of castor oil are in 10 -15 thousand tons, total production capacity is about 55,000 tons per year. The world's major markets of castor oil were concentrated in North America and Europe, of which the France, Britain, Netherlands, United States, Germany, five countries accounted for 61% of annual fuel consumption. India castor oil used in making soap has about 1.6-1.8 million tons, the textile industry uses 2-3 thousand tons, chemical industries use 2-3 thousand tons, lubricating oil use 5-6 thousand tons, the rest for exporting. In Japan's castor oil use amount, paints accounted for 28.6%, the surfactant is 12.3%, cosmetic raw material is 8.2%, resin is 5.7%, hardened oil is 17.8%, sebum oil is 12.9%, others is 14.5%. Japan needs to import large quantities of castor beans every year; they are mostly imported from China, Pakistan, Indonesia, Sri Lanka, Philippines, Vietnam, Ethiopia, Brazil and other countries. Castor oil in the United States for the production of plastics and resins was accounted for 25.9%, fatty acids accounted for 12.7%, lubricating oil accounted for 6.3%, paint accounted for 23.7%, cosmetics (mainly synthetic waxes) accounted for 2.1%, others such as inks, surfactants accounted for 29.1%, these castor oils are imported from foreign countries. Every year, the world needs 700 thousand tons of castor oil, convert into 1.6 million tons castor beans. Nowadays, gasoline resource was gradually reduced, transportation, live used gasoline was rapidly increasing, use gasoline as a raw material for synthetic material will be increasingly constrained in cost. And the United States study found that long-term exposure to polymers which synthesized by gasoline was harmful to human health. California and some other states have enacted laws and regulations for this, to restrict and gradually prohibit using synthetic resin in city buildings, interior facilities and human health-related sites and articles, which is polymerized from petroleum, natural gas cleaved into monomers raw materials, it makes castor oil's demand was rising sharply. Castor cultivation in China is very commonly; there is no open planted regional division. South from Hainan Island, north to Heilongjiang is cultivated. Because castor hybrids with drought resistance, thin ridge resistant, saline-alkaline tolerance, well-adapted, simple to manage, less invest, high efficiency and other salient features, no matter grain field or hills, rocky land, saline-alkali soil and even around the house can be grown it. So anywhere in China can be planted castor. Related Products 
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3738) Lack of Sleep Could Be Doing This to Your Heart
Date:
January 01, 2017 01:59 PM
New mothers, college students and emergency room doctors all have something in common: sleep deprivation. But is getting little to no sleep on a regular basis bad for your health? The evidence says yes. According to a recent study, getting less than three hours of sleep within twenty-four hours causes increased strain on the heart, elevated blood pressure, and increased heart rates. Thyroid hormones and cortisol also went up, which can lead to stress and eventually heart disease. It is clear that getting enough sleep is in your best interests in the short- and long-term, along with a healthy lifestyle. Key Takeaways:
"Getting less than three hours of sleep during a 24-hour period causes immediate heart problems, according to a new study presented at the annual meeting of the Radio logical Society of North America. Researchers looked at 20 healthy adults." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3728) Can Cannabis Help with Inflammation for Athletes?
Date:
December 24, 2016 07:59 AM
With opioid dependence and overdose deaths reaching epidemic levels, athletes suffering from injuries need alternatives to widely prescribed painkillers. Research suggests that components of the cannabis plant, including THC, CBD, and terpenes can play a role in reducing pain and inflammation. Although it is not as powerful a painkiller as opioids, cannabis could be used to help wean athletes off of opioid medication, as well as manage long-term chronic pain. Key Takeaways:
"One possible alternative to prescription painkillers may come from certain components of the cannabis plant. Recent studies have found that cannabis could possibly reduce inflammation, acting almost like Tylenol." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3693) The real secret to a healthy heart
Date:
December 22, 2016 07:59 AM
Regular exercise helps to keep your heart healthy. There are numerous ways to exercise your heart, but interval training is one of the best ways. Interval training increases your heart rate for minimal amounts of time and works to strengthen the muscles of the heart. By bringing you heart rate up, then letting it rest, then stressing it again, your body works to simulate a very difficult workout when in fact you are not working too hard. Key Takeaways:
"Resistance training, also called strength training, has benefits for your heart, too. Long-term resistance training can help lower blood pressure." Reference: //www.mayoclinic.org/the-real-secret-to-a-healthy-heart/art-20270834
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3684) Replacing carbs with protein? Don't overdo it
Date:
December 17, 2016 07:59 AM
Protein has become the dietary supplement that everyone is talking about. With benefits thought to range from building muscle to losing weight, protein powders and bars have become a staple in American society. Specialists are beginning to wonder if getting too much protein in the diet can lead to bad side effects. It is estimated that most American men consume double the daily recommended intake. There are concerns that high protein diets can lead to the development of diabetes and liver disease. They are cautioning people to keep their intake closer to the recommended dosage. Key Takeaways:
"A canned protein drink can contain almost as much protein as a 227g steak, and snack bars or a small bag of protein chips can pack more of the macro-nutrient than a three-egg omelette." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3661) Honeybee memories: Another piece of the Alzheimer's puzzle?
Date:
December 14, 2016 12:59 PM
A recent study at the University of Queensland has set out to research how Alzheimer’s can affect memory by studying how honeybees create and forget memories. They found that honeybees have an amazing memory. Not only can they remember where a food source was once found, but they also can orient themselves based on landmarks and remember how good the source was. The theory was that methylation of DNA is a molecular change in the brain that causes memories to be formed. By preventing some bees from being able to methylate, they were able to prevent them from forming memories. Key Takeaways:
"Scientists know that when a memory is formed, molecular changes can trigger physical changes to the brain, including new or altered neural connections and activity." Reference: https://www.sciencedaily.com/releases/2016/12/161208125919.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3642) Brain tumor vanishes in 'Miracle Baby' after family chooses cannabinoid oil
Date:
December 02, 2016 02:59 PM
The spontaneous disappearance of a tumor is referred to as a vanishing tumor. Most vanishing tumors in the brain are eventually diagnosed as malignant tumors or multiple sclerosis. However, their long-term clinical course remains unclear. This study aims to elucidate the management of vanishing tumors in the brain. Patients with vanishing tumors should be followed up carefully by magnetic resonance imaging for at least 5 years, even after the disappearance of an enhancing lesion. Key Takeaways:
"At four months the tumor had completely disappeared, and after eight months of treatment, the brain architecture and tissues were completely normal, making the toddler a miracle baby in Courtney's words." Reference: //www.naturalnews.com/056022_cannabis_oil_brain_tumors_medical_marijuana.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3554) The top 10 worst ingredients found everywhere across the survival foods industry
Date:
November 16, 2016 04:49 PM
Survival foods sometimes have ingredients that are not as healthy as you may think. Many foods from companies like WISE Foods or Mountain House are actually full of chemicals and harmful ingredients. Some of the ingredients include corn syrup solids, modified corn starch or Disodium Inosinate. There is a healthier option for survival foods though--Organic Family Pack from Numanna. This option is GMO free and free of chemical preservatives. Key Takeaways:
"Long-term storable foods are one of the preparation items you should be considering and buying." Reference: //www.naturalnews.com/055891_survival_food_Organic_Family_Pack_Numanna.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3456) Are These Factors Causing Inflammation In Your Body?
Date:
November 08, 2016 03:04 PM
Inflammation is caused by a number of factors. For instance, the hormonal changes experienced by women during menopause can cause chronic inflammation. The production of the hormone cortisol during stressful moments can also contribute to inflammation. Some foods are another possible contributor. For instance, polyunsaturated oils like peanut, soybean and corn lead to inflammation. Consuming a diet balanced in omega-3 and omega-6 fats can help balance this out. Inflammation can have negative long-term consequences on the body, so it’s best to consult a doctor and make healthy lifestyle choices. Key Takeaways:
"Along with other factors, there are certain foods that you consume which might end up causing inflammation. These are regular food items that we have without even realising that they are the cause of inflammation." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3408) 5-foods diabetics should add to their diets
Date:
November 04, 2016 02:04 PM
While type II diabetes is typically treated with conventional medicine, diet can also help manage the condition. People with type II diabetes should consider reducing their carbohydrate intake and adding a number of beneficial foods to their diet. Foods like avocados, black beans, and cinnamon can help manage type II diabetes. Read on for the top 10 foods diabetics should add to their diet to manage their condition. Key Takeaways:
"Monounsaturated fats can subdue blood cholesterol levels and slow the absorption of other sugars." Reference: //diabetestips.co/5-foods-diabetics-should-add-to-their-diets-fox-news/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3386) Are Laxatives Safe For Your?
Date:
April 26, 2014 10:03 PM
Herbal laxatives could promote bowel activity with mild purgation. They are usually used when there is a blood toxicity, constipation, an infection that cleansing of people bowel is needed, insufficient fiber in diet, a skin condition which caused by insufficient elimination, gallstones or hypertension. Common laxatives The most common laxative herbs used are senna, cascara sagrada, sesame, psyllium and milkweed. Milkweed or Asclepias syriaca is an old home remedy for warts, and medicinally important in heart disease treatment. The seed of Psyllium contain copious amounts of the mucilage, which are able to treat constipation, diarrhea and act as an effective and safe weight loss aid. Why Would You Use Laxatives? For relief of constipation you might suppose to use laxatives. Constipation is a gastrointestinal disorder, which make result in fewer or difficult bowel movements. Low fluid or fiber intake is the common causes of constipation. You will discover that bulk-forming laxatives are usually recommended for first aid when you have a constipation problem that will draw fluid into your intestines. However, it is not recommended to use laxatives in long-term, because it could give you harmful side effect. The Pros and Cons of Taking Laxatives Laxatives were used for conditions like irregularity, painful elimination and hard stools. For temporary use laxatives are help to treat some chronic condition and invaluable. However, using laxatives for long-term use may give you several risks: cramping, bloating, nausea, gas and diarrhea. The most important risk you might want to know, is your body will be dependent on that herbs. It is an important option to consult to your doctor when having a risk of laxatives. Since there are some risks of using laxatives, you would like to try the alternatives of laxative when you are planning to use in a long term. Here are some valuable alternatives: Fiber rich food, drink plenty of water daily and exercise regularly.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3105) Why Choosing 7-Keto DHEA Over Standard DHEA
Date:
February 25, 2012 06:36 AM
The Importance OF DHEA Nowadays DHEA (Dehydroepiandrosterone) is probably one of the most abundant hormone that can be found in the human blood. Being produced in the adrenal cortex, this important steroid it's very important in reducing body fat, cholesterol and also the alleviate angina. In addition to all that, DHEA has been widely used to treat coronary artery disease, Alzheimer's, sclerosis, depression, osteoporosis and even cancer. Because of this, DHEA is known under the name of “Fountain of youth.” DHEA levels will usually decrease with age. This decrease might lead to high cholesterol levels, cardiovascular disease, neurodegeneration and even obesity in many cases. These are only a few reasons that make of DHEA an imperative hormone for our body. What Makes 7-Keto DHEA Better Than Standard DHEA? 7-Keto Dhea it's similar to its cousin hormone, however it is much better for your body. Some of its extra benefits that can't be find in the standard DHEA are: - Enhances your immune system. - Improves your memory. - Increases your muscular mass and strength. - Help you lose fat naturally. - Increases the activity of your thyroid gland. - Reduces the signs of aging. Overall, 7-Keto DHEA is a safer and a more potent derivates of standard DHEA, proved to be safer and with less side effects. 7-Keto DHEA is a real breakthrough as it represents the next generation of DHEA supplements. How was this discovered? In the previous years, the University of Wisconsin conducted an extensive research in order to discover the best DHEA derivates. Over more than 150 DHEA derivates analyzed, a single compound stood out- it was 7-Keto DHEA. This compound provided greater benefits over a long-term period than the standard DHEA. Nowadays it is considered an improved and much safer form of this important hormone, called DHEA. In addition to providing all therapeutic benefits of DHEA, this improved hormone won't be converted into some unwanted sex steroids. It also lacks any other hormone- elevation that was commonly found in the standard DHEA supplements. This product makes you feel young again without endangering your body tissues or internal organs, compared to the traditional DHEA whose side effects were found destructive to some of your body tissues. Why To Take This Hormone? 7-Keto Dhea was proven to be a safe product in a clinical trial, being tested on many people and animals. The only side effects this hormone might have are some mild heart palpitations and sometimes acne. Still, these side effects won't usually appear on people who take this product as prescribed and also avoid taking an overdose. The benefits this hormone provides to our body are very real, as they were discovered at those who took this hormone for a longer period of time. Enhancing your immune system, the response to viruses is stronger. You will feel healthier and better protected. When Should You Take It? This hormone is to be taken only after you reached 30 years old, as you won't need it before that age. DHEA hormone begins to decrease considerably only after you reach 30, so this process will continue until you reach 70 or 80 years old. Taking the 7-Keto Dhea hormone will help you feel and be younger.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2593) History And Uses Of Xylitol
Date:
February 07, 2012 07:50 AM
Xylitol is the 5-carbon sugar which is found within the birch tree sap and it's naturally found in the fibers of various vegetables and fruits. This is a sugar-alcohol sweetener commonly used as the sugar substitute. History of xylitol Although discovered in the 19th century during the Second World War, Xylitol has been recognized ever since the tardy 1800s. The researchers from Germany and France were the first individuals to try to produce this product approximately 100 years ago, but ended up creating syrup-like consistency mixture. This product became commercially available in the 1960s and the commercial process is still the same as it was during the 1960s. Before 1943, the scientists' categorized this sugar with various sugary carbohydrates (polyols) and it lingered so till the beginning of the war-associated deficiency of sugar which initiated the call for an alternate sugar. This initiated further research in to the xylitols insulin-independent properties, this resulted in discovery of its other biological benefits. In 1962 this chemical was introduced in the infusion therapy demonstrating that it can be introduced to ill individuals. The commercial production process involves extraction of Polysaccharides rich in Xylose from various agricultural by-products and hardwoods. These are hydrolyzed with various intense acidic treatments and then it is purified before hydrogenation is done. This process needs a lot of harsh chemicals and is quite expensive and inefficient. It was until 1970 that the odontological benefit of xylitol was ascertained in Finland, Turku. The initial study of the effects of this sugar on the dental plaque began during the same year. This resulted in large scale production of xylitol, in 1974 by the Finnish sugar company. Sugar-free dental product was first launched in Finland which was a xylitol chewing-gum. How xylitol works This sugar can prevent cavity in various ways by actually blocking the tooth decaying process. The bacteria causing decay cannot ferment this sugar into acids as it does with other sugars including dextrose, fructose, glucose and sucrose. This results in production of less acidic by-product thus interfering with the dental plaque environment which favors decaying. This results in prevention of tooth demineralization. The high pH condition caused by xylitol sugar is not favorable for the cariogenic bacteria which are responsible for decaying. This results in fewer bacteria in the plaques and long-term exposure has an effect on which type of bacteria will prevail within the plaque. This also inhibits the growth of specific xylitol-sensitive bacteria strain. Since they cannot breakdown this sugar, they end up not reproducing and growing in population. The lack of fermentable sugars results in creation of anti-cavity effect. The starvation effect created by this sugar prevents accumulation of cariogenic bacteria in the plaques. Long term xylitol exposure results in change of predominant cariogenic bacteria to xylitol-resistant strains from xylitol-sensitive. This xylitol-sensitive strain of bacteria cannot colonize the plaque since they have less adhering capabilities. The less acidic condition in the dental plaque interface created by this sugar can initiate demineralization. Demineralization occurs when the plaque interface is at a pH of 5.5 or below since fewer bacteria live in the plaques. Studies have showed that demineralized tooth samples immersed in a solution containing 20% xylitol experienced a great remineralization degree. This is noted in the deep and middle tooth layers.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2558) Fight Inflammation, Gastric Problems, and Arthritis with Boswellia
Date:
June 14, 2011 11:49 AM
How Does Boswellia Fight Inflammation.
Boswellia fights inflammation through the action of a family of anti-inflammatory terpenes known as boswellic acids. Inflammation is a natural reaction of your immune system to tissue damage and infection, and is often associated with conditions such as arthritis, sports damage to bones and joints and bacterial infections caused by cuts and grazes. There are more serious inflammatory conditions of course, such as asthma, and boswellic acids act in the same way as non-steroidal anti-inflammatory drugs (NSAIDS) without their unwelcome side effects. Among the causes of inflammation are inflammatory mediators such as leukotrienes, the biosynthesis of which is blocked by boswellia. Another is the 5-lipoxygenase enzyme, also known as LOX-5, and again, the terpenoid anti-inflammatory boswellic acids block this so that the causes of inflammation in the above conditions are severely restricted. Boswellia extract is a good supplement to take for those suffering any form of arthritis, joint pain or even asthma. Using Boswellia to treat Arthritis Boswellia can be used to treat both osteoarthritis and rheumatoid arthritis, although rheumatoid arthritis is not always easy to control. Arthritis is an inflammatory condition, in the case of osteoarthritis the inflammation being a natural response to joint damage and infection of the synovial fluid generally caused by wear and tear on the joint with aging, and also by sports injuries. Rheumatoid arthritis is a form of immune disease caused by the body attacking its own joints, and while the terpenoid anti-oxidants known as boswellic acids can help to mediate the pain and other symptoms, it can do nothing to cure the condition. If you are suffering pain through arthritis, and your joins are tender and swollen, a supplement consisting of an extract of boswellia or its terpenes can help to relieve these symptoms and to offer pain relief equivalent to that offered by synthetic NSAIDs such as aspirin and Ibuprofen. Gastric Problems and Arthritis Pain? Perhaps Boswellia Can Help Extracts and supplements based on the resins of the boswellia tree are commonly used to treat inflammatory conditions, and reduce the severe pain of rheumatoid and osteoarthritis, ease the discomfort of colitis and also help ease the symptoms of those suffering asthma. Each of these is an inflammatory condition that would otherwise have been treated using NSAIDs, or non-steroidal anti-inflammatory drugs. NSAIDs have a number of side effects, being particularly unsuitable for those with ulcers or any other gastric problem. The terpenoids contained in boswellia extract an effective alternative to these drugs that many try to avoid taking. Long-term use of boswellia appears a lot safer than long-term use of NSAIDs, since it doesn't promote the severe gastric problems of these synthetic drugs, such as irritation of the stomach lining or even ulcers. If you already have ulcers or other gastric problems then NSAIDs area define no-no for you, and boswellia is the ideal substitute. Grab some boswellia today and experience relief for your self!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2336) How Stress Affects Your Adrenal Glands
Date:
June 08, 2011 02:00 PM
Avoiding Stress Is Hard To Do In Todays Fast World.Your two adrenal glands lie just above each of kidneys, and they are responsible for the hormones that initiate the flight or fight response to stress, and also the way you handle stress. Cortisol is the hormone that primarily determines how you react to stress, while adrenalin and noradrenalin determine whether you stand and fight when threatened, or take flight to avoid undue danger. The adrenals also generate androgens and estrogen, though these are mainly produced in the testes and ovaries respectively. When you suffer long periods of stress, such as long-term illness or worry over financial problems or job loss, your adrenals can slow down their production of cortisol and your ability to handle stress gradually fails. This results in sleeplessness, long periods of tiredness and a progressive slowing down of your vital organs. It is imperative that you receive the correct treatment, yet many doctors do not recognize the condition of adrenal fatigue as a genuine one. By taking substances such as the ancient Chinese remedy schizandra, that improves your ability to handle depression and stress, or andrographis that appears to have a stimulating effect on your adrenals, you can overcome this condition and both you and your adrenal glands get back to their normal selves. Avoiding stress is the best way to recover from adrenal fatigue, but this is virtually impossible now a days. Taking herbal remedies like Schizandra and a good B-Complex can help you recover from adrenal fatigue and reduce the feeling of fatigue. Give Schizandra or a B-Complex a try today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2327) How Important are Minerals in the Body
Date:
May 07, 2011 11:33 AM
Minerals And Your Health.Minerals are nutrients necessary for human life. They are often found in the foods we eat at dietary quantities. Living a healthy lifestyle always means having the right amounts of minerals in our diet. Each mineral has a daily value, which necessitates its consumption on a regular basis. Not meeting the requirement for a single mineral for extended periods of time will lead to deficiency. Deficiency in any nutrient will always impact our health. Minerals are especially important because they are very pervasive throughout the human body. They even affect the digestion and absorption of other nutrients. It is common knowledge that long-term deficiency in any mineral will have deleterious effects on human health that may even result in malnutrition and faster progression of diseases. Quantity Minerals Dietary minerals are actually chemical elements that are involved in countless chemical reactions in the human body. It is very probable that various tissues and organs will collapse when these elements progressively decrease. Some elements are necessitated in relatively large amounts, and this group of minerals is called quantity elements, which include potassium, chlorine, sodium, calcium, phosphorus, sulfur, and magnesium. Human health is quite sensitive to low levels of these minerals. Potassium is an electrolyte present in systemic circulation to regulate blood pH. Chlorine is generally obtained from table salt, which is indispensable in the synthesis of gastric acid. Sodium, like potassium, is a systemic electrolyte that also participates in many cellular functions. Calcium is required by almost all tissues, and absolutely necessary for bone health. Phosphorus is involved in the upkeep of several tissues, including bones. Magnesium plays a pivotal role in the metabolism of energy. Trace Minerals Trace minerals refer to dietary elements that are needed in, as the name suggests, minute quantities. A significant fraction of the global population has been reported to be deficient in most of these elements in that their intake has been associated with foods that are not consumed on a daily basis. In the past few decades supplementation seems to be the only certain way to obtain healthy levels of trace elements, which include zinc, iron, manganese, copper, iodine, selenium, and molybdenum. Zinc is necessitated by over a hundred proteins that belong to all classes of enzymes. Iron prevents iron deficiency anemia since it is central to the production of hemoglobin. Manganese binds to proteins and activates their biological roles in enzymatic reactions. Copper and molybdenum participate in the metabolism of oxygen, which occurs in every cell of the body. Iodine is pivotal to the biosynthesis of thyroid hormones, influencing physical growth, mental development, and metabolic rate. Selenium boosts the immune system and improves the antioxidant defense of cells. The scientific community has estimated the recommended daily allowance for each dietary mineral for good reason. Regular intake of minerals helps ward off diseases and keeps our body in prime condition. Minerals are essential for life, are you getting enough of them daily?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2290) I Am a Vegetarian, Should I be Taking a B-12 Vitamin Supplement?
Date:
February 28, 2011 12:52 PM
Vitamin B12 And Your HealthVegetarians are especially in risk of deficiency in vitamin B12 in that there are no plant sources known to contain significant levels of this essential nutrient. While the body is capable of storing this vitamin in the liver enough to meet the daily needs for several years, those who are following a strict vegan diet for long periods of time are in danger of developing many different medical conditions, including heart diseases, neural impairment, and anemia. Most vegetarians do not realize the seriousness of vitamin B12 deficiency as its symptoms often materialize in later life when the damage may no longer be reversible. Fortunately, total vegetarians do have options without renouncing their beliefs, inasmuch as Vitamin B12 supplements have shown to meet the nutritional needs of the body. Removes Neurological Problems One of the mishaps of long-term vegetarianism is the incidence of neural tube defects in babies, inasmuch as developments in the nervous system in the first periods of pregnancy is compromised in women who have very low levels of vitamin B12 does not have enough even with excessive quantities of folate. Nerve cells in particular are very sensitive to the absence of this vitamin. Many vegetarians are under the impression that plants contain every nutrient that the human body needs, which is completely misleading. Only bacteria have the enzymes required to manufacture vitamin B12, and these bacteria are present in the gut of animals. The good news is that vitamin B12 supplements that are available in the market today are good source of the active forms of this vitamin, and has stood the test of time in reversing the deficiencies brought on by malnutrition. Prevents Cardiovascular Diseases High levels of homocysteine are another consequence of low levels of vitamin B12 in the blood. A rise in homocysteine concentrations in the blood serum is a very important risk factor for cardiovascular diseases, and may come to an extent that is no longer reversible. Atherosclerosis and coronary heart disease are among the disorders tied to elevated homocysteine in the bloodstream, the reason why supplementation vitamin B12 has been used to treat certain medical conditions involving the heart and the blood vessels. The availability of vitamin B12 is in fact inversely proportional to the quantities of homocysteine produced by the body, and supplementation starting in the early years has shown to remove all the dangers related to homocysteine. Supplies the Body with Energy It is a known fact that vitamin B12 supplements affect chemical processes implicated in the production of energy. They are now widely accepted to be good for individuals involved in endurance sports and for the regular guy who usually relies on caffeine. Vitamin B12 stimulates the conversion of fatty acids into cellular energy, and influences the production of red blood cells, producing the vitality we need minus the jittery effects of coffee. For athletes, it does not only provide energy but also ensures cardiovascular health as homocysteine levels are directly proportional to exercise duration. If you do not eat much red meat and do not take a supplement, you might be deficient or boarder line at best in vitamin B12. Taking a supplement is the easy way to boost B12 and improve your health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2245) Taurine - Essential or Non-Essential Amino Acid - You Decide?
Date:
February 17, 2011 10:56 AM
Amino Acid Taurine Is Essential For More Than You ThinkTaurine is an organic compound with acidic properties, which is synthesized in the pancreas in adults, but an essential amino acid in infants. Many neutraceutical products for infants are fortified with taurine, inasmuch as some newborns do not have the enzymes required to synthesize taurine. Taurine deficiency in adults results from deficiencies in other organic compounds, notably methionine and cysteine, which are its immediate precursors within the body. Helps in Brain Development It has long been postulated that taurine plays an important role in the human brain, especially in infants, protecting the nerve cells from possible neonatal damages. Taurine continues to affect the nervous system as we age, acting on gamma-aminobutyric acid, or GABA, and consequently enhances inhibitory synaptic transmissions. In addition, taurine is alleged to stimulate continuous activation of synapses characteristic of long-term potentiation, which memory and learning ability stem from. Stabilizes Glucose Levels Taurine is a powerful inhibitor of glycation, a process by which sugar molecules attach themselves to other biomolecules without the aid of enzymes, and thus subsequently impair the functions of these biomolecules. This process may take place inside or outside the body, but the substances that result from this process, which are referred to as advanced glycation end-products or AGEs, contribute to the formation of a number of major disorders in later life such as cardiovascular diseases, Alzheimer’s disease, age-related deafness and blindness, and cancer. Taurine keeps the cells from taking up AGEs from the blood, which is slowly excreted in the urine. Regulates Adipose Tissues It has also been observed that dietary taurine influences the metabolic pathways that give rise to the formation of adipose tissues, the fat reserves of the human body. These fat depot appear anywhere in the body, but are commonly tied to the subcutaneous fats, those that we see on the belly, chest, arms, and thighs. Moreover, body fat percentage has been an indicator of obesity, which is central to the use of taurine in regulating adipose tissues. Influences Lipid Absorption Taurine is a major component of bile, the fluid produced by the liver, stored in the gallbladder, and secreted in the small intestines to aid in the digestion of triglycerides, cholesterol, and other lipids. Also, several studies point to the effect of taurine on the binding of proteins to lipids to form lipoproteins, compounds that have been notoriously labeled as bad cholesterol. Not surprisingly, taurine has been suggested to maintain healthy levels of blood cholesterol and prevent cardiovascular diseases. Fights Oxidative Stress Sodas have become a part of our daily diet today, but little did we know that they are risk factors for oxidative stress, the continued peroxidation of cellular structures. Fructose in sodas and other sweetened beverages is the most dangerous of all sugars, inasmuch as it releases by-products called AGEs, which are highly reactive to oxidation. AGEs do not get excreted right away and are instead absorbed by cells, leading to irreversible damages to neuronal and vascular tissues in later life. Intake of taurine removes this problem. Have you had your Taurine Today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2239) How does Malic Acid help with Fibromyalgia?
Date:
February 09, 2011 01:18 PM
Malic Acid And Fibromyalgia
If you feel sensitized to pain by otherwise harmless stimuli, then you may be experiencing symptoms of fibromyalgia, which has been recorded to affect up to 4 per cent of the population worldwide. It is characterized by a feeling of weakness in the muscles of the limbs, conscious awareness of abnormal heartbeat, problems concerning bowel movement, and disturbances to sleep patterns. All of these are complaints reported to have been addressed by supplementation of malic acid. The medical community remains inconclusive as to what causes fibromyalgia, some claiming it’s not a disease at all. While symptoms may not be necessarily medical signs, there are innumerable cases that describe complaints we collectively refer to as fibromyalgia. Throughout the past few decades, medical professionals around the world have considered these symptoms as one musculoskeletal disease whereas most neurologists have contended that fibromyalgia is attributable to the abnormalities within the nervous system. Today the American College of Rheumatology has charted nine paired tender points in an effort to describe the symptoms for this condition better. Known Causes in Scrutiny The most common symptoms of fibromyalgia more often than not appear simultaneously with stress-induced medical conditions such as chronic fatigue, anxiety disorders, and depression, but they are known to develop independently. A tissue in the brain responsible for long-term memory and spatial navigation called hippocampus have shown abnormalities among patients of fibromyalgia, thereby affecting sleep patterns, perception of pain, and related cognitive functions. In the latter half of the 20th century it is postulated that serotonin leads to fibromyalgia. Serotonin being a neurotransmitter that governs mood, attention, and pain were found to be significantly decreased in the blood plasma and cerebrospinal fluid among patients who reported to experience this condition. That being said, the introduction of serotonin inhibitors used in treatment of depression has also shown alleviations of pain-related symptoms across the tender point index.
Malic Acid and PrognosisMalic acid was discovered as a constituent of apple juice as early as the 18th century. Reduced levels of malic acid contribute to the maturity of fruits. In human beings it plays a fundamental role as an intermediate in a metabolic pathway that influences the chemical conversion of bioactive compounds like carbohydrates, fats, and proteins into carbon dioxide and water, which in turn convert the molecules contained in the cytoplasmic fluid of cells into energy generated in the mitochondria. The availability of malic acid inside the human body modulates functional activities at the cellular level by speeding up the metabolism of bioactive compounds and consequently the production of energy in use by the cells. That being said, malic acid provides vitality to muscle cells, raising their endurance against stress. In addition, there have been reports that intake of malic acid help elevate levels of serotonin, leading to improved response to pain and better management of fibromyalgia. For now, the tender point index is the primary diagnostic tool for evaluating fibromyalgia, and the use of malic acid has been recorded to reduce pain in these points.
Have you had your Malic Acid today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2233) How to detoxify from heavy metal aluminum toxitity
Date:
November 09, 2010 06:04 PM
When aluminum salts accumulate in the brain, seizures and reduced mental function can often result. In order to reach the brain, aluminum must pass the blood-brain barrier, which is an elaborate structure that filters the blood before it reaches the vital organ. Although elemental aluminum does not ordinarily pass through this barrier, certain aluminum compounds, such as aluminum fluoride, will. Many municipal water supplies are treated with aluminum sulfate and fluoride. These two chemicals readily combine with each other in the blood and are poorly excreted in the urine. The absorption of high levels of aluminum and silicon in the intestines can result in the formation of compounds that accumulate in the cerebral cortex and prevent nerve impulses from being carried to and from the brain in the proper manner. This situation can be aggravated by a chronic calcium deficiency. People who have spent their career in aluminum smelting plants for long periods have been known to experience dizziness, impaired coordination, and a loss of balance and energy. When aluminum accumulates in the brain, the above symptoms are often caused. Perhaps the most alarming thing to note it that there is evidence to suggest that long-term accumulation of aluminum in the brain may contribute to the development of Alzheimer’s disease. It has been estimated that an ordinary person ingests about 3 and 10 milligrams of aluminum a day. Aluminum, being the most abundant metallic element in the earth’s crust, is primarily absorbed in the body through the digestive tract, but can also be absorbed through the lungs and skin. Additionally, aluminum can be absorbed by and accumulate in the body tissues. Since aluminum permeates our air, water, and soil, it can be found naturally in varying amounts in almost all food and water. Aluminum is also used to make cookware, cooking utensils, and foil, along with being present in many other everyday products including over-the-counter painkillers, anti-inflammatories, douche preparations, antacids, baking powder, food processing, antiperspirants, toothpaste, dental amalgams, bleached flour, grated cheese, table salt, beer, and municipal water supplies. The following nutrients are very helpful when dealing with aluminum toxicity: apple pectin, calcium, magnesium, coenzyme A, garlic, kelp, lecithin capsules or granules, l-glutathione, a multivitamin and mineral complex, SAMe, vitamin B complex, N-Acetyl Cysteine, and vitamin E. Additionally, the following herbs are great for blocking damage to the body from toxic heavy metals and radiation when taken regularly: burdock root, Echinacea, ginseng, ginkgo biloba, and fiber. Other recommendations to help prevent aluminum toxicity include maintaining a diet that is high in fiber and includes apple pectin; using only stainless steel, glass, or iron cookware, with stainless steel being the best; and being aware of the products that contain aluminum by reading labels and avoiding those that contain aluminum. Sulfur container foods like N-Acetyl Cysteine can help find up heavy metals and eliminate them from the body. If you suspect you have heavy metal toxicity, consult your health care provider immediately. ~facebook~
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2195) Build Healthy Bones With A Good Bone Builder Supplement
Date:
May 22, 2010 12:17 PM
Silicon, boron, and zinc are also required in order to strengthen the bone’s mineral matrix. Vitamin C stimulates the formation of the collagen matrix, which is an extremely important protein component that creates a structure for calcium crystallization. Silicon increases the bone-mineral density. Additionally, it seems to have a role in the prevention and treatment of osteoporosis. Silicon deposition is found in areas of the body that experience active bone growth. Because of this, it is suggested that this mineral may be involved in the growth of bone crystals as well as the process of bone mineralization. Zinc is also important for the proper action of vitamin D, as its status plays a huge role in bone health. When an increase in zinc excretion takes place, accelerated depletion of bone-mineral content also results. This situation is very common among osteoporosis sufferers. Diets that are low in zinc have also been shown to slow adolescent bone growth as well. Lastly, vitamins B6, B12, and folic acid are necessary for reducing mineral loss as they modulate blood homocysteine levels. Vitamin B6 is a water-soluble vitamin used in the metabolism of amino acids. Vitamin B12 is one of eight B vitamins which is crucial for the normal functioning of the brain and nervous system, as well as the formation of blood. It is normally involved in the metabolism of every cell of the body. It affects DNA synthesis and regulation as well as fatty acid synthesis and energy production. Folic acid is a form of the water-soluble vitamin B9. It occurs naturally in food and can also be taken as a supplement. The scientific evidence that has been found has supported the need for long-term supplementation with several key nutrients in order to maintain bone health. This is especially true for those women who are in their peri- and post-menopause years. Supplementation with vitamins D, K, C, B6, B12, folic acid, as well as the minerals boron, calcium, magnesium, silicon, and zinc at levels that are declared to be suitable for optimal nutrition health by nutritional authorities is an important component of product-rating criteria. Researchers question whether each product contains vitamin D, vitamin K, vitamin C, vitamin B6, vitamin B12, folic acid, boron, calcium, magnesium, silicon, and zinc at potencies that are up to 100% of the potencies for these nutrients that are stated in the Blended Standard. Look to your local or internet vitamin store for bone building formulas that contain all these essential vitamins to help the body support a healthy bone structure. Remember to always choose name brands like Eithical nutrients and Solaray to ensure you buy a high quality complete bone building supplement.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2161) The Good and Bad of an iron supplement
Date:
April 25, 2010 06:04 PM
The dark side of iron supplementation comes when iron is consumed in amounts that are excessive to the body’s needs. Although unbound iron is more likely to cause oxidative challenges through the generation of free radicals, excessive iron supplementation in any form can cause huge problems for the cell. The overload of iron can cause deterioration of the gut lining, vomiting and diarrhea, abdominal and joint pain, liver damage, loss of weight, and intense fatigue. In children, acute doses as low as 3 grams can cause death.
About one out of every 250 North Americans suffer from haemochromatosis, which is a genetic defect that is common in a lot of those people of northern European descent. This disorder causes the body to accumulate and abnormally store high levels of iron. Those people with haemochromatosis store twice as much iron as others, which places them at increased risk for iron-related diseases. Symptoms of these diseases generally occur after fifty years of age and often include things ranging from fatigue, abdominal pain, achy joints, impotence, and symptoms that mimic diabetes. Several studies have produced evidence which suggests that high levels of iron contribute to noticeable increases in the risk for cardiovascular disease. This is likely due to non-haeme iron’s aggressive pro-oxidant nature. Iron levels are one of the strongest biochemical markers for the progression of atherosclerosis, which results from increased oxidation of LDL cholesterol. A study in 1995 conducted on Finnish men found that those who had high body stores of iron also had a substantially increased risk of heart attack. Those men who posses the highest levels of stored iron often showed a levels of risk that was up to three times that of men who possessed the lowest levels of stored iron.
Disorders in iron accumulation contribute to a whole host of other disease states, all of which are degenerative in nature. Studies have shown that chronic iron overload contributes to increased infections, cancer, arthritis, osteoporosis, diabetes, and various congenitive dysfunctions. The only way to remove excess iron is through blood letting, unless you are a woman with regular menses. That is why, for men, iron overload can provide quite a problematic issue. Recent research has found But for those who need iron, it can easily be obtained through a vitamin supplement at your local or internet health food store. Men should avoid iron supplements and products containing iron, but women on the other hand due to monthly blood loss should supplement with iron regularly.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2157) Hawthorn Berries
Date:
September 17, 2009 10:57 AM
This herb contains many different components which work together to benefit the heart and body. Hawthorn can both feed and strengthen the heart and arteries. It seems to work on the heart muscle to make it work more effectively. The herb may even help a damaged heart. Hawthorn contains some mild sedative properties, which can help when heart disorders are due to stress and with insomnia. Hawthorn has been used to treat and prevent arteriosclerosis, rapid heartbeat, feeble heartbeat, enlarged heart, angina, and breathing difficulties due to a lack of oxygen in the lungs. Some people recommend using hawthorn to protect against disease before symptoms occur. Hawthorn is known for its ability to regulate arterial blood pressure. It increases the strength of the heart muscle and also works to increase coronary blood flow. This herb is great in helping to reduce the heart rate and lessen the heart’s workload.
Some studies have found that this extract is responsible for dilating the blood vessels, which results in reduced peripheral resistance. Hawthorn may also have some further cardio-protective effects that become pronounced after prolonged use. Research on 132 patients found substantial positive results with the use of this herb. These stage two stable heart failure patients had improved exercise tolerance, and a reduction in shortness of breath and fatigue after exercise. The researchers noted that for maximum effect, hawthorn must be used for one to two months. Cardiac improvement accelerates with long-term use and relatively high doses. The berries and flowers of the hawthorn plant are used to provide alterative, antispasmodic, astringent, cardio-alterative, diuretic, sedative, and vasodilator properties. The primary nutrients found in hawthorn are choline, inositol, and vitamins A, B-complex, and C with bioflavonoids. Primarily, hawthorn is extremely beneficial in dealing with angina, arrhythmia, arteriosclerosis, high and low blood pressure, heart conditions, heart palpitations, and hypoglycemia. Additionally, this herb is very helpful in treating arthritis, blood clots, edema, hypertension, insomnia, liver disorders, rheumatism, sleeplessness, and stress. For more information on the many beneficial effects provided by hawthorn, please feel free to contact a representative from your local health food store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2081) Kava Kava Root
Date:
September 05, 2009 12:11 PM
Kava is an ancient crop of the western Pacific. The word kava refers to both the plant and the beverage that is produced from its roots. Kava is a tranquilizer that is primarily consumed to relax the body without disrupting mental clarity. The active ingredients found in this herb kavalactones. Kava extract is marketed as an herbal medicine in some parts of the Western world, fighting against stress, insomnia, and anxiety. It has been concluded that this herb is more effective than a placebo at treating short-term social anxiety. Safety concerns have been raised over liver toxicity, but research indicates that this may be largely due to use of stems and leaves in supplements, which were not indigenously used. Kava is used by many island communities in the Pacific in their ceremonial drinks as a mild sedative and relaxant. Among these include Polynesia, Micronesia, and Melanesia. This herb was used to relax the body and mind and to promote restful sleep. Kava is considered to be an important herb for pain relief. It is also helpful for insomnia and nervous conditions. This herb is recommended to be used as a strong muscle relaxant. It is considered to be one of the most powerful of all of the herbal muscle relaxants. Kava is used as an analgesic sedative, for rheumatism, for insomnia, and to relax the body. Studies have determined that kava contains anticonvulsant and muscle-relaxing properties. This may be extremely helpful to those people who have stress-related muscle tension or seizures. Those individuals who drink kava often relate the effects to a sense of tranquility and sociability. The herb helps to achieve a feeling of well-being and relaxation. Kava seems to have an advantage over other drugs that are prescribed for anxiety and insomnia because it does not seem to lose effectiveness over time. A variety of studies have shown that there is a significant benefit for individuals who are suffering from anxiety. This is extremely promising for those individuals who require long-term therapy for anxiety disorders. Kava is not addictive and is free of associated complications. This is different from many of the medications that are routinely prescribed. Kava also provides benefits as an analgesic for pain relief. The chewed leaves of this herb cause numbness in the mouth. This anesthetic activity is similar to cocaine and it lasts longer than benzocaine. The root of the kava plant is used to provide alterative, analgesic, anesthetic, antifungal, antiseptic, antispasmodic, aphrodisiac, diuretic, and sedative properties. The primary nutrients found in this herb are calcium and magnesium. Primarily, kava is extremely beneficial in dealing with insomnia and nervousness. Additionally, this herb is very helpful in treating anxiety, asthma, bronchitis, fatigue, pain, rheumatism, uterine infections, vaginitis, and venereal diseases. It is important to consult your health care provider before taking this herb so that you do not have any adverse reactions to medication which is associated with this herb. In order to obtain more information on the many beneficial effects provided by kava, please feel free to contact a representative from your local health food store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2074) Natural Vitamins under Attack
Date:
June 29, 2009 02:53 PM
The value of nutritional supplements in protecting and promoting human health has been intensely debated in recent years throughout the scientific and medical community as well as the national press. Many researchers believe that supplements provide a convenient and effective way to supply the optimal amounts of essential nutrients that are necessary for supporting long-term health, while others argue that there is no proof that supplements provide any real health benefits at all. A lot of the debate has been published by media that is more interested in selling papers than reporting the truth. Because of this sloppy reporting and distorted information, the public has been unnecessarily alarmed, causing them to lose trust in complementary health care. It is crucial that this false information be addressed before harm that is irreversible is done to an industry that is committed to natural approaches to wellness and a public that is increasingly confused as to where to turn for truthful advice on preventing disease and achieving optimal health. The mixed messages that have been reported in the headlines have confused both health-conscious consumers and medical practitioners, as one day they’re told something is good for them and the next day they’re told it is not. If there is any consolation to this whole thing, it may be helpful to understand that science never progresses smoothly, as there are always new findings that appear to disprove long-held beliefs. Controversy is necessary for change, as it paves the road that science must travel in order to arrive at the real truth. Unfortunately, bias in the media and conflicts of interest add an unnecessary element to finding the real scientific truth. When looking at the recent studies that have been negated, there are several explanations that arise for the findings that seem to contradict prevailing scientific evidence. First of all, several long-term dietary intervention trials have recently come about which were developed in the early 1990s before good and bad fats were differentiated. Because of this design, these studies simply assume that all fat is the same, and to reduce fat, one must cut out all kinds of fat. Secondly, it has been proven that there will always be a statistical fluke in a bunch. Therefore, out of 100 clinical studies to investigate a particular effect, probability states that five of these studies, no matter how well they are designed, will show results that are not real. Thirdly, it is expected that about one fifth of clinical trials that investigate a particular effect will not have the needed number of subjects to produce a result that is statistically significant. This is so because in most clinical trials there is only an 80% probability of finding a real result, which is known as the power of the test. Because of this, there is up to a 20% chance completely missing the mark and failing to find a difference when one actually exists. Finally, some investigations are just bad science, as they are improperly conducted, poorly reported, and inadequately reviewed. Unfortunately, these studies attract a great deal of attention from the media, which has been the case recently. Natural vitamin supplements can feed the body and help the body fight disease and stay wall. The foods we eat determine what kind of health we will have, if we eat poorly, we will live with poor health. This is why we should consume a multiple vitamin and mineral as well as herbs and food concentrates to help supply our diet with the needed nutrients to sustain and maintain a good healthy lifestyle. Look to your local or internet health food store for vitamins, herbs, and food concentrates.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2026) Colostrum
Date:
June 18, 2009 10:54 AM
After going through puberty, our bodies gradually decrease in the production of immune and growth factors that generally combat disease. After losing these vital components, we are much more susceptible to the aging process, which shortens our life expectancy. Colostrum and its other components have the ability to fight off bacterial and viral invaders as well as stimulate tissue repair, which is something that becomes increasingly vulnerable as we age by boosting the immune system. For all of these reasons, it is important for an adult to supplement with colostrum. Colostrum should be collected during the first 24 hours after birth. Also, a colostrum supplement should be processed in a USDA licensed facility. This insures the consumer that USDA guidelines are being followed. Additionally, consumers should make sure that products labeled Colostrum are actually 100% colostrum, not colostrum or concentrates of milk whey. Lastly, colostrum that is mixed with other supplements or herbs and additives may have a diluted colostrum concentration, which means the benefits you could obtain from this supplement may be compromised. Even though colostrum has no interactions with drugs, side effects may be experienced from a cleansing or healing crisis, which is a necessary but somewhat inconvenient and adverse result. Fortunately, once the healing crisis is complete, you will feel substantially better and in good terms of health. Mediations may need to be re-evaluated by your medical profession for dose and need. Although colostrum is generally believed to be very safe for those mothers who are pregnant and nursing, one should probably ask their medical professional prior to taking colostrum or its specific agents while they are pregnant. Just like any other supplement or drug, it is better to be overly safe and check with a healthcare provider before jeopardizing a pregnancy. Colostrum is recommended specifically for children who have not already received the mother’s breast milk, as breast milk would have already provided the benefits that would be obtained through colostrum supplementation. Those children with flu, colds, bacterial or viral infections, or children who have been on long or short-term antibiotics or other drugs are good candidates for colostrum supplementation. Therefore, colostrum supplementation is safe and may be recommended for these types of children. Many people wonder if colostrum products can pass on mad cow disease. At this time, no case of mad cow disease has been reported in the United States. With awareness of the disease being so high, it is extremely unlikely that one would contract mad cow disease from a colostrum product. The overall supplementation of colostrum and other products that contain derivatives of colostrum has been shown to extremely safe. Additionally, it has been shown that colostrum is equally effective, whether it be taken by injection or by mouth. It has also been shown that the long-term administration of colostrum preparation is very safe to the human body. Because infants and the elderly are the two main groups that are especially at risk for infections, many people may wonder just how safe colostrum products are for these two groups of people. Not only is oral administration safe, it is also very effective and easily accepted by both of these groups. Colostrum is available in capsule of tablet forms at your local or internet health food store. Look for name brands like Kal and Source Naturals to ensure quality and purity of the product you purchase. *Statements contained herein have not been evaluated by the Food and Drug Administration. Colostrum is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2020) Boswellia Extract
Date:
June 11, 2009 06:16 PM
The boswellia family of trees are specifically known for their fragrant, gummy sap, which possesses many medicinal uses. Among these, especially, if the use as an anti-inflammatory. It is believed that the frankincense of the bible was actually an extract from the resin of the Boswellia tree. Boswellia, which is also known as boswellin, has a long history of use in Ayurvedic healing. The resin is called salai guggal and has been used to treat asthma, arthritis, various inflammatory conditions, and to relieve joint pain and pain that results from sports injuries. The resin of the boswellia tree is also though to be helpful for treating back pain as well as some other chronic intestinal disorders. The boswellia plant is a genus of trees that are known mainly for their fragrant resin. This resin has many pharmacological uses, particularly as anti-inflammatories. There are four main species of boswellia, producing true frankincense. Each type of resin is available in various grades. These grades depend upon the time of harvesting. The resin of the boswellia plant is hand sorted for quality. Anyone who is interested in frankincense is advised to obtain a small sample from each reputable dealer to determine the difference between each resin. Boswellic acids are the main compounds that are believed to be at the source of boswellia’s anti-inflammatory properties. These acids have the ability to inhibit the enzymes that induce pain and inflammation in the body. A few studies have been conducted on boswellia’s effect on sports injuries and arthritis. Among these, some have shown that boswellic acids may contain anti-inflammatory benefits that are extremely powerful. These benefits are similar to those found in ibuprofen and aspirin. One study done on rheumatoid arthritis patients found that pain and swelling were reduced after three months of treatment with boswellia. Those who used boswellia occasionally reported mild gastrointestinal distress, like heartburn and nausea, but there were no other reports of serious side-effects. Boswellia has a long tradition of safe and effective use as a mild anti-inflammatory to alleviate pain and stiffness. It is also used to enhance mobility without serious side effects. However, further research is needed to confirm the long-term safety and effectiveness of this extract. Boswellia seems to be best taken as needed in order to reduce pain and stiffness, as opposed to being taken regularly as a maintenance herb. The resin of boswellia is used in many herbal formulas because of its analgesic and anti-inflammatory properties. Primarily, this extract is most useful in dealing with arthritis, asthma, inflammatory conditions, joint pain, and sports injuries. A boswellia standardized extract is recommended by many doctors. When dealing with rheumatoid arthritis or osteoarthritis, 150 mg of boswellic acids are taken three times per day. For example, if an extract contains 37.5% boswellic acids, 400 mg of the extract would be taken three times daily. Treatment with boswellia should generally last between eight and twelve weeks. Generally, boswellia is safe when used as directed. Rare side effects include diarrhea, skin rash, and nausea. Any inflammatory joint condition should be closely monitored by a health care professional. To date, there are no well-known drug interactions with boswellia. Boswellia comes in capsule form at your local or internet health food store. When making a purchase always read the label to ensure that the product is standardized to its active acids to ensure quality and purity and to ensure that the herb when taken regularly will function as intended. *Statements contained herein have not been evaluated by the Food and Drug Administration. Boswellia is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2017) L-Carnitine
Date:
May 07, 2009 05:45 PM
L-carnitine is amino acid essential for the metabolism of fats into a form of energy necessary for extended aerobic activity. Originally discovered in Russia, and Germany a year later, the structural formulation of carnitine, as it is correctly known, was determined in 1927, although it is physiological and biochemical activity was not understood until the 1960s. The amino acid is biosynthesized in the liver and kidneys from lysine and methionine. The vitamins niacin, B6, C and iron are essential for this reaction to take place. However, the supply of L-carnitine has to be supplemented by the diet, good sources being dairy products, red meat, nuts and seeds, pulses and fruits such as apricots, bananas and avocado. Most of the L-carnitine supply of the body is stored within the muscle tissue. However, it is not unusual for conditions to arise making it difficult for the body to obtain all the carnitine required. L-carnitine enables fatty acids to be transported into the mitochondria, where cell metabolism occurs. The biochemistry is discussed below, although in simple terms the amino acid allows body fats, in the form of triglycerides, to be made more readily available for the generation of energy required for extended exertion. In this way, body fats can be used for energy and the supplies of glycogen stored by the liver can be retained for emergency use. By providing the energy for endurance and stamina in this way, carnitine makes use of an otherwise unavailable energy source, and has the added benefit of reducing body fat stores and reducing strain on the heart. Although there is generally a plentiful supply of L-carnitine available in a healthy diet, supplementation can ensure that a deficiency does not occur. Supplements are available in the form of L-carnitine or its acetylated derivative, acetyl L-carnitine. In order for fatty acids to be used in the production of energy, their long-chain acetyl groups have to get inside the mitochondria where they are oxidized to the acetate to be used for the production of energy via the Citric Acid or Krebs cycle. In order for the biochemistry to take place, fatty acids must be rendered suitable for binding to the carnitine molecule. The chemical grouping with a good affinity for L-carnitine is the acetyl or acetyl group, available in the molecule acetyl coenzyme A (CoA). The free fatty acid, therefore, is attached to coenzyme-A by means of a thioester bond, catalyzed by means of the enzyme fatty acetyl-CoA synthetase. The reaction is then completed by means of in organic pyrophosphatase. In this way, the fatty acid in the form of an acetyL-carnitine derivative can be transported through the mitochondrial wall. This transportation takes place by means of several steps. These are: 1. As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I. This enzyme is conveniently located on the outer mitochondrial membrane. 2. The enzyme carnitine-acetylcarnitine translocase helps the acetyL-carnitine through the membrane. 3. Another enzyme, carnitine acetyltransferase II, located on the inner mitochondrial membrane, converts the acetyL-carnitine to acetyl-CoA, liberating the carnitine which returns to the muscle mass. L-carnitine is the only known substance that allows fatty acids to cross the mitochondrial membrane, and therefore deficiencies must be avoided. Another way in which carnitine is used in energy production is in the Krebs cycle itself. Part of this cycle involves the conversion of guanine diphosphate to the higher energy form guanine triphosphate. In this way energy can be stored in much the same way as it is in the conversion of ADP to ATP. Succinyl CoA is involved in this conversion, and one of the by-products of it is a corresponding succinate, that is then converted to a fumarate by the action of L-carnitine fumarate. Carnitine, therefore, has two parts to play in the production of long-term energy from the fatty acids contained in body fats. Since the fatty acid triglycerides contained in body fats are a major source of energy in the heart and skeletal muscles, it is easy to understand how L-carnitine is believed to lead to the increased energy levels required for stamina and staying power. A major reason for its effect on longer-term or extended energy requirements is that in enabling stored body fats to be used for immediate and longer-term energy requirements, L-carnitine allows emergency glycogen stores to be retained for use once immediate fatty acid supplies or those of carnitine have been depleted, and so allows the energy supply to be extended even farther. Research has also suggested that the amino acid can possibly be used to treat liver and kidney disease, diabetes and chronic fatigue syndrome. As with many supplements, the question is often asked how does L-carnitine work in practice as opposed to the claims made for it by the supplement providers? Recent research indicates mixed results, but sufficient to justify its use. It is generally accepted that a supplement is necessary when there is a deficiency, but once that deficiency has been corrected further intake is unnecessary. However, it is also believed that during long and extended periods of exercise a carnitine deficiency does occur as L-carnitine is used up, and the supplement is necessary to ensure sufficient energy supply throughout the period of exercise. There has also been a case reported in the Journal of Clinical Neurology (Negoro, Tsuda, Kato & Morimatsu, 1995) where a deficiency, caused by anorexia nervosa damaging the liver to the extent that it was unable to synthesize L-carnitine, was remedied by means of an oral supplement. Studies on endurance athletes have been mixed, ranging from no effect to L-carnitine being found to promote weight loss. Carnitine has no unknown harmful side effects, and has been studied for medical applications other than as an energy supplement. For example it possesses extensive antioxidant properties, and can be used as a supplement against oxidative stress and the prevention of the lipid peroxidation that is a precursor to atherosclerosis. Its use in osteoporosis and reducing bone mass is also being studied. The concentration of L-carnitine diminishes with age, and affects fatty acid metabolism in a number of tissues. Bones are particularly affected since they require continuous reconstruction. Without detailing the biochemistry involved in this, administration of carnitine helps to reduce the speed by which this occurs. Trials are so far been carried out only on animals. In studies on both healthy volunteers and patients with type II diabetes, L-carnitine was found to improve storage of glucose in both groups, although its oxidation increased only in the group with diabetes. Other studies carried out include improving the function of neurotransmitters in the brains of elderly patients and in the treatment of Alzheimer's and Parkinson's disease, and other neurological disorders. In conclusion then, although the jury is out on the use of L-carnitine is an energy-giving or weight-loss supplement, it appears to be effective where the body's stores of carnitine could be depleted such as with long-term exercise, natural deficiencies or deficiencies caused through age. It is also under study in the treatment of various medical conditions. On balance, it would appear that the prospective benefits of L-carnitine render it worthy of use.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2004) Stop Constipation
Date:
March 29, 2009 10:08 AM
Constipation occurs when one has difficulty passing stools, or infrequently passes hard, dry stools. This is the result of food moving extremely slowly through the large intestine. From time to time, most people experience constipation. However, lifestyle changes and better eating habits can help to relieve the symptoms and prevent recurrences. Constipation usually results from insufficient amounts of fiber and fluids in the diet. Fiber can be found in plant foods like whole grains, fruits, and vegetables. Fiber that is water-soluble takes on a soft texture and is helpful in softening the stools. Insoluble fiber goes through the large intestine unchanged and is helpful in adding bulk to the stools to stimulate bowel contractions. Other factors that can cause constipation include inadequate exercise, advanced age, muscle disorders, structural abnormalities, bowel diseases, neurogenic disorders, and a poor diet, especially a heavy consumption of junk food. Constipation can also be a side effect of iron supplements and some drugs, like painkillers and antidepressants. It is also common during pregnancy. High levels of calcium and low levels of thyroid hormone can also lead to constipation. Those with kidney failure are also prone to having problems with constipation. Constipation is often caused by dehydration in older individuals, with depression being a factor in people of any age. Some medications, like cough syrups, pain medications that contain codeine, antidepressants, iron supplements, blood pressure and heart medicines, calcium supplements, and some antihistamines can also cause constipation. A small percentage of people with spinal injuries and other similar problems have constipation because the nerves that usually regulate bowel movement have been damaged or destroyed. A condition referred to as Hirshsprung’s disease makes the normal excretion of feces impossible because the nerves inside the bowel are missing. The nerve cells in the colon can also be damaged by long-term use of laxatives, which makes constipation inevitable. A thrombosed hemorrhoid, anal fissure, or a pocket of infection at the anus can create a spasm of pain that is strong enough to contract the muscles and prevent the evacuation of stools. Constipation can cause a variety of other ailments such as appendicitis, bad breath, body odor, coated tongue, depression, diverticulitis, fatigue, gas, headaches, hemorrhoids, hernia, indigestion, insomnia, mal-absorption syndrome, obesity, and varicose veins. It may even be involved in the development of other serious diseases like bowel cancer. It is important to have regular bowel movements in order to remove toxins from the body. Toxins from bowel bacteria and undigested food particles play a part in the development of diabetes mellitus, meningitis, myasthenia gravis, thyroid disease, candidiasis, chronic gas and bloating, migraines, fatigue, and ulcerative colitis. People can have bowel movements as infrequently as three times a week and still not be constipated, but there are some health practitioners that believe that it is important to have a bowel movement every day. The following nutrients are very helpful in dealing with and preventing constipation: garlic, vitamin C with bioflavonoids, apple pectin, chlorophyll liquid, essential fatty acids, a multi-enzyme complex, a multivitamin and mineral complex, vitamin B complex, vitamin D3, vitamin E. Additionally, the following herbs are also beneficial: alfalfa extract, fennel seed, aloe vera, ginger, milk thistle, triphala, cascara sagrada, goldenseal, rhubarb root, senna leaves, and yerba mate. Adding a good fiber supplement as well as the above mentioned supplements can help one stop constipation and start normal bowel movements again. Natural fiber, vitamins, and herbs are available at your local or internet health food store. Look for name brands such as Source Naturals, Solaray, Kal, Planetary Formulas, and Natures Plus to ensure quality and safely of all your natural supplement needs.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins, herbs, and fibers are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1984) Copper Vitamins
Date:
February 13, 2009 10:47 AM
Copper is an essential trace mineral that can impair the ability of white blood cells to fight infection with even the slightest deficiency. Copper is necessary for the proper absorption of iron in the body. It is found primarily in foods that contain iron. If the body does not get a sufficient amount of copper, hemoglobin production decreases, causing copper-deficiency anemia to potentially result. There are a variety of enzyme reactions that require copper. Copper is essential as a cross-linking agent for elastin and collagen. It is also a catalyst for protein reactions and is also needed for oxygen transport. Copper is used for the metabolism of essential fatty acids. Copper deficiency can result in a variety of symptoms. Among these symptoms are diarrhea, inefficient utilization of iron and protein, and stunted growth. The development of nerve, bone, and lung tissue can be impaired in babies and the structure of these body parts may also be altered. Because the body is unable to manufacture copper, it must be obtained through the diet. Too much copper trace mineral produces a condition known as copper toxicity or copper overload. In order for the body to work properly, it is essential that it has a proper balance of copper and zinc. An imbalance can lead to thyroid problems. Additionally, low copper levels can contribute to mental and emotional problems. For example, copper deficiency may be a factor in anorexia nervosa. Although the FDA has never published a Recommended Daily Allowance for copper, the National Research Council recommends that adults get from 1.5 to 3.0 mg per day, while children obtain 1.5 to 2.5 milligrams and infants less than six months old obtain 0.4 to 0.6 milligrams. For most people, a normal healthy diet will provide the correct amount of copper. Copper deficiency is most likely to occur in babies who are fed only cow's milk, persons suffering from a malabsoprtion syndrome known as sprue, persons suffering from kidney disease, and those who chronically take mega-doses of zinc. Long-term use of oral contraceptives can upset the balance of copper in the body. This can cause either excessively high or excessively low copper levels. Copper levels can be determined through a blood test, urine samples, and hair analysis. The basis for a nutritional program to balance body chemistry is determining mineral levels and ratios. The following nutrients are helpful in combating copper deficiency. The dosages recommended are for adults unless otherwise specified. For a child between the ages of twelve and seventeen, the dosage should be reduced to three-quarters the recommended amount, while one-half the recommended amount should be used for a child between six and twelve. A child under the age of six should use one-quarter the recommended amount. Copper should be taken in dosages of 5 mg daily for a month, and then reduced to 3 mg daily. This helps to restore copper in the body. It is recommended that a copper amino acid chelate is used. 30 mg of zinc should be taken daily, as it is needed to balance with copper. This amount should not be exceeded and a zinc chelate form should be used. Iron should be taken as directed by a physician, as copper deficiency may cause anemia. Be sure to use a chelate form and do not take iron unless anemia is diagnosed. Additionally, a multivitamin and mineral complex should be taken as directed on the label since all nutrients are necessary in balance. In conclusion, copper is a wonderful mineral that can help one with immunity and much more. Remember that copper should only be taken in low dosages of 1 to 3 milligrams per day. Copper can be found at your local or internet health food store. *Statements contained herein have not been evaluated by the Food and Drug Administration. Copper is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1965) Hoodia
Date:
January 29, 2009 03:52 PM
Some companies are already manufacturing a blend of cheaper ingredients with hoodia, and claiming it is better than hoodia alone. This means that you might find a product that contains 1,000 mg of total ingredients, but it could contain as little as 50 mg of hoodia. As a general rule, the other ingredients are only included to make the product cheaper. All hoodia supplies are the same strength worldwide. The stems of the plant are picked, dried, and milled, leaving a powder about 5 percent of the original weight, which is why some quote it as a 20:1 extract. However, don’t be misled. Despite what a label may lead you to believe, you’re only getting 50 mg of hoodia. The minimum dosage that is necessary to have a usable effect is about 800 to 1,200 mg of actual hoodia each day. This amount will help to reduce your appetite so that you can eat smaller meals and, consequently, lose weight. If you think you’d like to try hoodia, look for a product that has been naturally extracted and grown or ethically wild crafted without the use of chemical fertilizers, pesticides, or preservatives, preferably in a vegetarian capsule. Make sure that the product you use is a true standardized full-spectrum herbal supplement that does not include any fillers, binders, or common allergens. Also, keep in mind that even though safety reports to date are encouraging, no long-term safety studies have been performed. Additionally, there is no data on the possible interactions hoodia may have with other drugs. Hoodia is a non-stimulating herb, which makes it more suitable for a large range of people. Herbal stimulants such as guarana or kola nut, which both contain caffeine, can cause a large range of side effects such elevated heart rate and blood pressure, nervousness, and sleeplessness. P57, the active ingredient in hoodia, has no sedative effects. Losing weight and maintaining an ideal weight also requires changing attitude and lifestyle. If your main goal is to quickly lose weight so you can fit into your bathing suit, you may be able to achieve that lighter weight, but without exercise, you’re still going to look flabby. Even though the subjects in the hoodia clinical study did not exercise, you should, as exercise plays an important role in losing and managing weight along with overall health. Weight loss should be about your overall health. Without the proper eating habits, especially nutrition and exercise, you won’t be able to accomplish much. It’s true that less weight puts less stress on your cardiovascular system, but you need to exercise to strengthen your heart muscles. Proper nutrition and exercise also helps to prevent many other health problems, which includes fighting off many digestive ailments. If you’re considering trying hoodia for weight loss, experts suggest that you supplement with 800 to 1,200 mg a day, divided into two doses and taken with water. For best results, follow the manufacturer’s dosage instructions since products may vary. You should also follow a reduced-calorie diet of natural, unprocessed foods. Even though you can probably lose weight on a diet like this without supplementing with hoodia, adding hoodia may help you to stick to your diet better.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1962) Inositol And Choline
Date:
December 11, 2008 12:19 PM
Inositol is a member of the vitamin B complex family, being referred to as vitamin B8, but is not strictly a vitamin because it is biosynthesized in your body. Vitamins are essential substances that are not manufactured by your natural biochemistry, and must be taken in your diet. However, to all intents and purposes it works like a member of the vitamin B family. The main function of myo-inositol (the commonest isomer of inositol) is in the health of cell membranes, particularly those that comprise the marrow, eyes, intestines and the brain. Without proper regulation of the cell membrane, the cell cannot function effectively. Some of its effects include healthy hair and controlling estrogen levels. It is also believed to help to reduce cholesterol levels in the blood. A deficiency will result in hair loss, eczema, increased blood cholesterol levels and eye abnormalities. You might also suffer constipation, although this is not as serious a condition as those preceding. It is present at highest levels in the heart and brain, which indicates where it is mostly used, although it also helps the liver to break down fats and enables the nerves and muscles to operate as they should. Those that are depressed are frequently found to have low inositol levels in their spinal fluid, so it is believed to play a part in that condition. It is known that the substance takes part in the function of the neurotransmitter serotonin, which is known to play a part in depression, and initial signs are that its use in the treatment of depression could be effective. Neurotransmitters are responsible for passing messages across the gap (synapses) between nerve cells, their messages being decoded by the neuroreceptors. A healthy nervous system depends on healthy neurotransmitters. For these reasons, inositol has also been tried on other conditions of the nervous system. These include bipolar disorder, bulimia, panic disorder, obsessive compulsive disorder and attention deficit disorder. So far, results have been inconclusive as to its effectiveness, but it is early days yet and field tests are continuing. A test carried out in Beersheva, Israel, in 1997, found that treatment with inositol produced significant improvement in the depression of 28 patients after four weeks on the Hamilton Depression Scale1, and 21 patients tested with panic disorder (with and without agoraphobia) showed significant improvements in their condition, including agoraphobia. Results on 13 patients with obsessive compulsive disorder also showed significant improvement. These were all double-blind tests. However, not all tests have been so conclusive, and a study on 42 people with sever depression who did not respond to conventional antidepressant, also failed to respond when inositol was added to their medication.2 Results are therefore not conclusive. Four hundred people took part in a double-blind test that indicated a possible improvement in the symptoms of polycystic ovary syndrome when treated with inositol 3,4 and another that inositol treatment on patients taking lithium could help reduce the symptoms of psoriasis, a skin condition believed to be caused by a reaction of the immune system and nerves.5 The supplement has also been found to be just as effective as Luvox (fluvoxamine – similar to Prozac) after four weeks treatment. Although these results are good, they are inconclusive, and more data is need before any indisputable conclusions can be drawn. However, treatment with inositol might be worth considering if conventional treatment for these conditions has been unsuccessful. The most common natural form of inositol is myo-inositol, an isomer of cyclohehexanehexol, a carbocyclic polyol that form the structural basis for secondary messengers in the cells of eukaryotes. A secondary messenger system is one whereby a signaling molecule is released in response to a signal from a primary messenger such as a neuroreceptor, which then activates certain intracellular proteins known as effector proteins that exert a response from the cell. An example is cAMP (cyclic adenosine monophosphate) that is a secondary messenger that activates protein kinases and allows them to phosphorylated proteins. Eukaryotes are organisms that contain cells composed of complex components contained within a cellular membrane, and that also contain a nucleus. Examples are fungi, plants and all animals. Examples of non eukaryotes include the bacteria family. It is frequently recommended that inositol is most effective when taken with an equal amount of choline, although this might be due to the fact that when inositol deficiency is detected, choline is also frequently deficient. Both are vitamin B family like, and both are lipotropic, in that they aid the breakdown of fats in the body. It is not clear whether this is true or not, but taking both would certainly not harm you, and might be of great benefit. Inositol is not essential, because it can be obtained from beans, nuts, seeds, whole grains, cantaloupe, brewer’s yeast, liver and vegetables. Bacteria in the gut also act on the phytic acid (inositol hexaphosphate) contained in citrus fruits to form inositol. However, be careful if you drink a lot of coffee. It destroys inositol, and if you are taking the supplement medicinally, steer clear of coffee during your period of treatment because it will lose its effect. Excessive coffee drinking can also result in a general depletion of inositol from your diet, and hence a deficiency. In such a case you are advised to take a supplement, preferably along with choline that might also be deficient. Although there have been no adverse side effects reported, no specific longer term safety studies have been carried out on inositol. Because of the way it works, inositol should be avoided by people with liver or kidney disease, and also by expectant or nursing women. It should be avoided by young children until safety tests have been carried out, and it is believed that it can cause manic effects in those suffering bipolar disorder. Other than for these specific cases, trials with many times the average daily intake of the substance, it currently appears safe to take inositol as a long-term supplement. However, as with all such supplements intended for specific disorders, you should seek the advice of your physician. References: 1. Levine J: Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev,Beersheva, Israel ur Neuropsychopharmacol, 1997 May, 7:2, 147-55 2. Nemets B, Mishory A, Levine J, et al. Inositol addition does not improve depression in SSRI treatment failures. J Neural Transm. 1999;106:795-798. 3. Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003;7:151-9. 4. Gerli S, Papaleo E, Ferrari A, et al. Randomized, double-blind, placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. 2007;11:347-354.
5. Allan SJ, Kavanagh GM, Herd RM, et al. The effect of inositol supplements on the psoriasis of patients taking lithium: arandomized, placebo-controlled trial. Br J Dermatol. 2004;150:966-969.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1948) Vitamins Herbs And Antioxidants
Date:
October 17, 2008 09:48 AM
Grilling meat over an open fire is something our ancestors have been doing for thousands of years. But people today who are indulging in chicken and cheeseburgers face a lot of concerns that our ancestors never even dreamed of. These include air pollutants and cancer-causing compounds. Research has proven that grilling meats creates two types of compounds that can lead to cancer. More so, both briquettes and lump charcoal spew hydrocarbons and soot particles as they burn, which encourage global warming contribute to many health problems. However, the majority of us cannot resist barbeque. So instead of dodging barbequed food, learn to grill without the guilt and fewer health risks. Barbeque emissions are well below those from motor vehicles and the industry in rank, but its environmental effects are just as harmful given that burning charcoal contributes to smog and global warming. Lump charcoal is actually made from charred wood, which is a factor in deforestation. It can be compared to fuels that we use in furnaces and water heaters, such as oil, gas, and wood. Like these other fuels, charcoal produces soot when it is burned. These particles in soot are air pollutants and microscopic solids which are inhaled and deposited in the lungs. Particle pollution is associated with asthma, strokes, heart attacks, lung cancer, and reduced life expectancy. Once animal fat drips onto the flame of a charcoal or gas grill, carcinogenic compounds rise with the smoke and are deposited on the meat. Other harmful chemicals are then formed on the food as it continues to char. The more time the meat spends on the grill, the more harmful chemicals that are created. These compounds do not form on vegetables, as it is a reaction with animal-based foods that generates the harmful effects. However, any food that is over-charred contains other types of cancer-causing substances. Grilling is a method of cooking that adds to the formation and deposit of cancer-causing substances on meat, as both substances deposited are undesirable and carcinogenic. The high heat of grill cooking produces more harmful chemicals than oven roasting or baking a lower temperature, but beef and chicken must both be cooked at temperatures high enough to destroy E. coli and other harmful bugs. Because cancer risk is influenced much more by long-term patterns than occasional patterns, the goal is to have a diet that balances calories you take in with calories you put out, and to eat a diet containing many fruits and vegetables. Grilling less meat and more vegetables can reduce pollution on many levels. Also, vegetarian sources of protein, such as veggie burgers, contain few or no harmful chemicals when grilled. So for those summer days when a barbecue is irresistible, be sure to use natural charcoal, which is made from environmentally friendly wood sources and low-emission plant wastes. Thankfully, all natural charcoals are chemical-free. In order to minimize cancerous compounds on the grill, cook at lower temperatures and flip meat every one to two minutes. Marinating meat or precooking it in a microwave for two minutes will also reduce hazardous compounds and carcinogenic compounds can be reduced by grilling lower-fat meats with fewer fat drippings.
By simply limiting the animal protein portion and making vegetables and grains a larger part of the meal, you can minimize the carcinogens and maximize your intake of cancer-protective vitamins and natural compounds. For most eliminating meat is undesirable, so supplementing with herbs and vitamins that help boost the immune system and act as antioxidants such as grape seed extract, vitamin c, and bioflavonoids can help the body fight off those nasty carcinogens produced from grilling.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1919) Lower Blood Sugar 
Date:
October 16, 2008 01:54 PM
Many people struggle to control their weight. However, while they are going on and off various diets, they fail to realize that they are also struggling to control blood sugar. Actually, the cause of blood-sugar problems may be weight problems, as being overweight and having blood sugar problems tend to go hand in hand. Too many blood sugar swings during the day tend to increase hunger jags, snacking, and overeating. When you overeat, you’re much more likely to add on the pounds, setting the stage for obesity, pre-diabetes, and full blown diabetes. Sadly, both pre-diabetes and overweight have become modern epidemics that are out of control, with two of every three Americans being overweight and over 100 million people having some signs of pre-diabetes. Both of these illnesses are nutritional disorders that result from eating too many unhealthful foods. However, there is good news: you can reverse pre-diabetes and control your weight. One can self-diagnose pre-diabetes by looking for the most visible symptom: being chubby or fat around the waist. Other clues are cravings sweets and starchy foods, not being hungry at breakfast, and feeling tired or mentally fuzzy after lunch. Many physicians diagnose pre-diabetes when a patient’s fasting blood sugar falls between 100 and 124 mg/dl. There are several dietary factors that significantly increase the risk of overweight. Some of these being: too many calories, too many refined carbs, especially sugars, and too many unhealthful oils. The average woman needs about 1,600 calories and the typical man needs about 2,000 calories daily, but the average American now consumes 3,900 calories each day, making it difficult to burn off all these calories and causing the accumulation of body fat. Because most excess calories take form of refined carbs and sugars, which are digested rapidly, rapid or extreme spikes in blood sugar levels, elevated insulin levels, and bouts of hunger result, which stimulate low blood sugar. Trans fats, which are found in partially hydrogenated vegetable oils, interfere with the body’s processing of fats and often lead to weight gain. Most of these problematic calories are found in fast foods, microwave foods, and other types of convenience foods, which are all best if they are avoided. Even though pre-diabetes can be scary, it’s actually an opportunity to improve your eating habits and regain your health. To improve your health you can emphasize quality protein, emphasize high-fiber vegetables and fruits, include grapefruit in your diet, use more vinegar, and add some cinnamon. Since protein stabilizes and safely lowers blood sugar levels, be sure to start each day with some protein with breakfast and eat a little protein with each meal. Most veggies and fruits are rich in fiber, which helps to lower blood sugar, so opt for salads and steamed broccoli while avoiding crutons, potatoes, bananas, and pears. Despite the calories, eating fresh grapefruit can help in weight reduction. The acetic acid in vinegar can also help to improve blood sugar and insulin levels, reduce appetite, and help with weight loss. Adding cinnamon has also been shown to reduce blood sugar levels. There are also several supplements that have exceptional value in improving insulin function or lowering blood sugar levels. These include lipoic acid, chromium, silymarin, omega-3 fish oils, vitamin D, and Pycnogenol.
You can also enhance the benefits of diet and supplements by increasing your physical activity as it helps build muscle and burn blood sugar and fat. Tackling pre-diabetes can not only reduce your long-term risk for health problems, such as heart disease and Alzheimer’s disease, but also can allow you to quickly gain more energy and feel less post-meal fatigue.
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Laxatives
Although aluminum is not a heavy metal, it can be toxic if present in excessive amounts or small amounts if it is deposited in the brain. Many of the symptoms of aluminum toxicity are similar to those of Alzheimer’s disease and osteoporosis. 
Since bones are living tissue, healthy bones need at least 24 bone-building materials in order to be at their best. These materials include both trace elements and protein. The most important minerals to bone health are calcium, magnesium, phosphorus, and potassium. The balance between these minerals is just as important as well. Strong bones need a lot of calcium, but calcium supplementation must include the presence of magnesium, as it increases the retention of calcium within the bone. Phosphorus is another important component in bone formation, as it must be in proper balance with calcium. If you take too much of it, which can be gained through soft-drink consumption or high protein intake, it will suck the calcium out of the bone, therefore, weakening the bone’s integrity. Vitamins D and K are also essential for increased calcium deposition. 
Iron holds a crucial role in the physiology of the body. It is a central part of the haemoglobin and myoglobin molecules. Iron is indispensable to the body’s ability to transport gases into and out of the cell. It is necessary in many important enzymes that are involved in energy production, metabolism, and DNA synthesis. Some iron is lost when red blood cells are broken down and excreted in the bile. However, because of iron’s importance, the body is able to conserve iron at all costs, as the kidneys do not eliminate the metal. 
that long-term supplementation with iron at doses less than 5 mg/day can lead to iron-overload toxicity. Because of this, it is recommended that the upper limit of iron intake be at 5 mg/day when considering a product’s rating. Any product that contains iron at a daily dose greater than this limit is penalized with this rating criterion. 
Ancient Greeks used hawthorn berries for heart disease. The Greeks and Romans looked to hawthorn as a source of happiness and hope for the future. The berries were used by the Chinese for digestion and circulatory problems. Christian legend says that the crown of thorns that was placed upon the head of Christ was made from hawthorn. The crushed fruit or leaves were used as a poultice for their drawing powers to remove thorns and splinters for centuries in England. Native Americans believed that hawthorn was useful for rheumatism and heart problems. 
One of the most positive facts about hawthorn is its safety. This herb is believed to be safe for long-term use without side effects. Some experiments have found that hawthorn dilates the blood vessels, lowers blood pressure, and strengthens the heart. This herb is commonly prescribed by German physicians to treat minor heart problems. Hawthorn also contains a mild sedative effect. This effect may contribute to a healthy heart. Stress, anxiety, and nervousness are often associated with heart conditions. 
