SearchBox:

Search Term: " Manual "

  Messages 1-14 from 14 matching the search criteria.
Herbs For Depression Darrell Miller 12/13/10
Capsicum - Cayenne Red Pepper Darrell Miller 7/28/08
Depression and Vitamins Darrell Miller 4/17/08
Carnitine Creatinate Darrell Miller 12/8/05
In men under 65, prostate surgery can save lives. Darrell Miller 7/27/05
Urinary problems are a common sign that prostate cancer has advanced. Darrell Miller 7/27/05
The benefits of a manual exam for prostate cancer far outweigh any embarrassment. Darrell Miller 7/27/05
10 Things You Should Know About Prostate Cancer Darrell Miller 7/27/05
HERBAL FIRST AID KIT Darrell Miller 7/11/05
HISTORY Darrell Miller 6/23/05
Menopause: Disease or Condition? Darrell Miller 6/13/05
Allergy Alleviation Darrell Miller 6/10/05
AMINO ACIDS AND PROTEIN Darrell Miller 6/9/05
Glycerylphosphorylcholine -- Supports Cognitive Function in AD ... Darrell Miller 5/24/05



LANSINOH LABORATORIES INC Manual Breast Pump
   1 ct $46.67 34% OFF $ 30.80

Herbs For Depression
TopPreviousNext

Date: December 13, 2010 12:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Herbs For Depression

Fight Depression with Natural Herbs

depression getting you down

Before discussing treating depression with natural herbs we should first consider depression itself: what is it and what causes people to become depressed? Psychiatrists and psychologists will suggest a number of definitions although most experts agree that there are two forms of depression.

Causes of Depression

Exogenous depression comes about as a result of external factors such as bereavement, heavy debt, job loss, etc, while endogenous depression comes from within and is believed to be due to biochemical problems, including food allergies, hormonal changes, thyroid problems, nutritional deficiencies, particularly Vitamin B deficiency, and addictions. There are many other reasons for people becoming depressed, some of which can be established by the particular symptoms of the individual.

In many cases of depression the external factors are often easier to treat than those due to internal factors. Many exogenous causes of depression such as bereavement are alleviated through time, while causes such as job loss and debt can be resolved once the cause has been rectified: thus, if the patient is no longer in debt or is re-employed, the depression tends to disappear with the cause.

Symptoms of Depression

Depression is not diagnosed from a single symptom, but from a number of symptoms that can point to a person being clinically depressed and requiring treatment. Among the symptoms of depression are:

Prolonged periods of sadness or despair
Feelings of pessimism for the future
Feeling generally tired and lethargic
Overeating with resultant weight gain or under-eating with resultant weight loss
Either insomnia or hypersomnia
Disinterest in family or work
Feeling of guilt, worthlessness and low self-esteem
Inability to concentrate
Hyperactivity or general inactivity
Suicidal thoughts

Forms of Depression

Many normal people can suffer one or two of the above systems, and would not be diagnosed as depressed because of it. We can all get mood swings, feel a bit worthless now and again or be unable to concentrate or focus at times, but that does not mean we are clinically depressed.

Depression would not be diagnosed in a patient with just one of these symptoms but five or more likely would be. In fact, the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders deem the patient suffering clinical depression if displaying 5 or more of the bottom 8 symptoms above for a month or more. This is believed to be the case with around 17 million Americans so it is a significant problem.

Manic depression is otherwise known as bipolar disorder, where patients have large mood swings from high and extreme hyperactivity and excitability to very low deeply depressive moods and is a clinical condition generally treated using drugs.

Treatment of Depression With Natural Herbs

The usual treatments are drugs that often have undesirable side effects; so many people are trying natural remedies instead. There are a number of herbs that can be used to treat depression, one of the most familiar being St. John's Wort. However, there are others, and here is a synopsis of each.

St. John's Wort

st johns wort picsSt. John's wort (hypericum perforatum) is likely the best known herbal treatment for depression. In fact, in Germany it is prescribed by doctors to children and adolescents for the treatment of mild depression and is available over the counter in many countries.

However, it can also be used in cases of severe depression, and a report in the Cochrane Database Review[8(4)] by K. Linde, M.M. Berner and L. Kriston in 2008 stated that of 29 separate tests carried out on a total of over 5,000 patients, the conclusion was that St. John's wort extracts were at least as good in treating severe depression with 5 times lower side-effects as tricyclic antidepressants and twice lower than the new selective serotonin reuptake inhibitors (SSRI).

It should be stated, however, that one trial on 340 subjects indicated no improvement over a placebo. However, the anti-depressive drug sertraline (Zoloft) was also shown to be no better than the placebo in this test, so some doubts must lie regarding its accuracy. Of all the herbal treatments, St. John's wort has had most testing carried out and it seems to be effective in treating mild to severe depression although not all experts are yet agreed.

Kava Kava Root

kava kava root picsKava kava can be used to treat depression and anxiety, largely due its content of kavalactones that are believed to increase the amount of a number of neurotransmitters in the blood, including the feel-good neurotransmitter serotonin. Kava kava root is mildly intoxicating, having much the same effect as alcohol, and can also reduce the symptoms of depression and anxiety.

However, it is doubtful if its effects are permanent and so it may be less of a depression cure as a short-medium term treatment. Its effects are also variable on different people, some describing it as making them feel relaxed and 'dreamy', while others find it therapeutic and making them feel better in themselves.

Kava kava should not be taken without your doctor knowing about because there have been concerns about its effect on the liver if taken in excess. A European-wide ban was lifted about two years ago after testing found the risks of taking it to be very low. It has been used for centuries as an intoxicating drink on islands such as Fiji.




Passion Flower

Passion flower has been used for centuries to treat anxiety, stress and depression, its active ingredients believed to be maltol and ethylmaltol that help to increase the level of gamma-aminobutyric acid (GABA) in the brain. GABA is one of the brain's key neurotransmitters and has been described by some as the brain's own 'Valium' supply.

Through the intervention of GABA, passion flower extract helps in reducing anxiety levels and makes you feel a lot calmer. If you suffer forms of depression that make you hyper or excitable, passion flower will help to reduce this and also helps to cure insomnia. It is a component of many natural sleeping pills.

These are just three natural substances that can be used to treat depression. However, you must inform your doctor or physician if you decide to take them since they may interfere with or change the effect of any antidepressant drug you are currently taking.

Call today for natural remedies for depression

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2207)


Capsicum - Cayenne Red Pepper
TopPreviousNext

Date: July 28, 2008 03:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Capsicum - Cayenne Red Pepper

Capsicum also known as cayenne pepper has been known to the natives of the tropical Americas for thousands of years. It was first introduced to Europe by Christopher Columbus as Guinea Pepper and was originally used by Native Americans that were located south of the Mexican boarder as early as 700 B.C. The mixture of chocolate and red chilies was a taste treat that was reserved exclusively for Aztec royalty. Although the exact origin of the word Capsicum is somewhat a mystery, it is assumed to be derived from the Greek word kapto, which means to bite. Capsicum is a fruit found on a shrub-like tropical plant that is technically considered a berry. The designation of it as a pepper can be traced back to Columbus, who compared its hot taste sensation with that, a black pepper.

Gerard referred to Capsicum as extremely hot and dry in 1597 and prescribed it to those with skin and throat infections. The health practitioners of the 1800s used Capsicum to counteract rheumatism, arthritis, depression, and chills. Capsicum was used in the early 1800s as a potent and safe natural stimulant and was believed to be able to treat a large array of diseases. It was first used orally to treat tumors, toothaches, fevers, and respiratory conditions.

This cayenne red pepper was introduced to England by Dr. John Stevens in 1804 when it became the catalyst component in many herbal blends. Additionally, herbal and medical practitioners used Capsicum in order to fight infection and sustain the natural heat that the body produces. After, it became very well known in American dispensatories and pharmacopeia. In 1943, The Dispensary of the United States recorded Capsicum to be a powerful local stimulant that produces a sense of heat in the stomach and a general glow over the whole body when it is swallowed. It does all of this without having a narcotic effect.

Physicians in the twentieth-century recognized the medicinal value of Capsicum. This caused the herb to find its way to the American Illustrated Medical Dictionary, the Merck Manual and Materia Medica, where it is named a rubefacient, local stimulant, counter-irritant, gastric stimulant, and diaphoretic. Mexican Indians today use Capsicum as an intestinal disinfectant and protectant against contaminated food and, additionally, to treat fevers. In the world today, this cayenne pepper is no more appreciated and more widely used than in Mexico and a few other Latin American countries, which together are the original home of all the peppers. Practically every dish the Indians eat both in the morning and evening include Capsicum, just as it was 2,000 years ago. These peppers are a wonderful source of essential vitamins in a diet that is otherwise lacking of them.

Capsicum is a source of health and vitality in many countries which include the Bahamas and Costa Rica, in which it is used to treat colic and indigestion, in Africa for vascular disorders, and in North America as a tonic and natural stimulant. Currently undergoing a large variety of studies, Capsicum has emerged with an impressive list of actions. Scientists are currently taking notice and looking at Capsicum with a new respect and interest. Capsicum can be set apart from powerful pharmaceutical stimulants and pain killers because it possesses the potency without the delirious side effects.



--
Buy Cayenne At Vitanet ®, LLC

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1844)


Depression and Vitamins
TopPreviousNext

Date: April 17, 2008 11:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Depression and Vitamins

Most men dealing with depression have stories that are very similar, waking with a heavy head even in the happiest of times. A bad day is described as one in which you can’t get out of bed and it feels as if there is a dark cloud hanging over your head. Today, as the NFL season moves towards playoffs, many athletes are living with depression related to multiple concussions. A study of over 2,500 retired NFL players concluded that three concussions triple the chance of experiencing depression. This is extremely important in a sport in which brain trauma is so often and easily dismissed.

Just like helmets cover the faces of men playing a violent game, the angry aggression that is so commonly associated with normal guy behavior may actually be a mask for depression and physical injury is not needed to suffer its effects. It has actually been discovered that depression is more common in men than anyone ever knew, as male depression has often been under-diagnosed because the standard diagnostic Manual portrays the depression symptoms more commonly associated with women. About six million men will be diagnosed with depression in 2008, not counting the one million more that will go undiagnosed.

The sad weepiness that is commonly associated with depression is much more commonly found in women, while a man is more likely to be short-tempered, fatigued, and uninterested in sex, work, or hobbies. However, it is work that provides depressed men a distraction to their painful inner feelings. Men are more likely to try downing their pain in alcohol or drugs instead of getting treatment. Untreated depression explains why the male suicide rate is more than four times the rate of female suicide. Although there are hormonal differences in depression of the different genders, the common factor is stress.

Although some men are open to being told they are depressed, most only act out with more anger. An effective, but not exactly subtle approach to telling a man he may have depression is leaving and article or book around the house for him to pick up. Severe depression requires immediate attention by a trained practitioner, along with various medical interventions. Once the worst is over, it is important to try to maintain a depression-free lifestyle. This can be done by reduction stress and finding social support as well as dietary changes.

This is a difficult step for men who are used to conversations which revolve around scores and transactions, but good places to start are men’s groups at houses of worship (church) or those groups such as AA if substance abuse is part of the problem. By fortifying the brain with depression-fighting nutrients, including a B vitamin complex, one can maintain and promote normal mental functioning. Many depressed people are extremely deficient in folic acid as well as dietary essential fatty acids.

Omega-3 fatty acids are needed to build healthy brain cells, along with phosphatidyl serine. Other herbs, including eleuthero, rhodiola, and ginseng, can help the body to adapt to stress, while St. John’s wort and SAMe work as natural antidepressants.

The most severe mistake that can be made is to play down depression, which applies to raging men just as much as it does to weeping women. Both genders need to seek help if feeling this way. If you feel you are experiencing depression, seek professional help as well as look into dietary changes, exercise, and the support of family can be a good start to a healthier outlook on life.

--
Vitanet ®, LLC

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1759)


Carnitine Creatinate
TopPreviousNext

Date: December 08, 2005 03:33 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Carnitine Creatinate

Carnitine Creatinate

Neil E. Levin, CCN, DANLA 6/30/05

LIKELY USERS: Athletes, Bodybuilders, Dieters, People who consume a lot of fat, People needing cardiovascular support (energy for the heart), People who need quick energy, especially for fast muscle response, People with muscle wasting problems (including the elderly), Weightlifters

KEY INGREDIENTS: L-Carnitine and Creatine Monohydrate

MAIN PRODUCT FEATURES: Carnitine Creatinate Monohydrate is a specialized form of Creatine bonded to L-Carnitine. Creatine is a compound natural to the human body that aids in the regeneration of ATP, the chemical energy used by muscle tissue. During exercise, large quantities of creatine are irreversibly consumed. Clinical studies have shown that oral supplementation with Creatine can increase the amount of Creatine available in muscles for ATP production. L-Carnitine is an amino acid that is necessary for the transfer of fatty acids into the fat-burning parts of the cell, facilitating energy production from fat. The combination of these two compounds can produce a synergistic effect, making NOW® Carnitine Creatinate an ideal energy supplement.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: Carnitine and Creatinate Monohydrate is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product. Protected by U.S. Patent No. 5,994,581 (L-Carnitine Creatinate Monohydrate).

Look at the price: this is a better way to buy both supplements than purchasing them separately.

This formula is suitable for vegetarians and is offered in both tablet and powder forms.

SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, every two tablets provide 1,000 mg. (one gram) each of both L-Carnitine and Creatine Monohydrate. Or one teaspoon provides 1,150 mg.) each of both L-Carnitine and Creatine Monohydrate. Take one or more servings per day with a carbohydrate source, such as fruit juice or sports drinks.

COMPLEMENTARY PRODUCTS: CoQ10, carbohydrates, B-Complex vitamins, chromium, vanadium, Hawthorn leaf and flower extract, protein supplements. Adaptogenic herbs: ginsengs, Eleuthero, Rhodiola, Maca, Ashwaganda, licorice root

CAUTIONS: none.

PRODUCT SPECIFIC: This product is very sensitive to moisture. Please keep in the original packaging or in a moisture resistant container. Do not take more than 20 grams per day. Discontinue use if cramps of stomach upset occur, especially if taking large doses. Do not take if kidney disease is present. Do not use large doses of caffeine with creatine, as it may increase the possibility of muscle cramping.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems.

Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

Fang S-M (1998) Carnitine Creatinate. U.S. Patent 5,994,581.

L-CARNITINE:

Beers MH, Berkow R (eds). The Merck Manual of Diagnosis and Therapy, 17th ed. Whitehouse Station, NJ: Merck and Co., Inc, 1999, 881-3.

Broquist HP (1994) Carnitine, in Modern Nutrition in Health and Disease, 8th ed., Shils ME, Olson JA, Shike M (eds.) Lea & Febiger, Philadelphia, pp. 459-465. Casey A, Greenhoff PL (2000) Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am J Clin Nutr 72(suppl):607S-17S. Columbani P, Wenk C, Kunz I, et al. Effect of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double blind crossover field study. Eur J Appl Physiol 1996;73:434-9.

Dal Negro R, Pomari G, Zoccatelli O, Turco P. L-carnitine and rehabilitative respiratory physiokinesitherapy: metabolic and ventilatory response in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1986;24:453-6.

Dal Negro R, Turco P, Pomari C, De Conti F. Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1988;26:269-72.

Del Favero A. Carnitine and gangliosides. Lancet 1988;2:337 [letter].

Dipalma JR. Carnitine deficiency. Am Fam Physician 1988;38:243–51.

Digiesi V, Palchetti R, Cantini F. The benefits of L-carnitine in essential arterial hypertension. Minerva Med 1989;80:227-31.

Giamberardino MA, Dragani L, Valente R, et al. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 1996;17:320-4.

Green RE, Levine AM, Gunning MJ. The effect of L-carnitine supplementation on lean body mass in male amateur body builders. J Am Diet Assoc 1997;(suppl):A-72.

Harris RC, Soderlund K, Hultman E (1992) Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 83(3):367-374.

Kendler BS. Carnitine: an overview of its role in preventive medicine. Prev Med 1986;15:373–90.

Kobayashi A, Masumura Y, Yamazaki N. L-carnitine treatment for congestive heart failure—experimental and clinical study. Jpn Circ J 1992;56:86–94.

Murray MT. The many benefits of carnitine. Am J Natural Med 1996;3:6-14 [review].

Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J Diabetes Complications 1999;13:251–3.

Yesilipek MA, Hazar V, Yegin O. L-Carnitine treatment in beta thalassemia major. Acta Haematol 1998;100:162-3. CREATINE MONOHYDRATE: Almada A, Mitchell T, Earnest C. Impact of chronic creatine supplementation on serum enzyme concentrations. FASEB J 1996;10:4567.

Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc 2000;32:654-8.

Casey A, Constantin-Teodosiu D, Howell S, et al. Creatine supplementation favorably affects performance and muscle metabolism during maximal intensity exercise in humans. Am J Physiol 1996;271:E31-E7.

Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci 1996;91:113-8.

Earnest C, Almada A, Mitchell T. Influence of chronic creatine supplementation on hepatorenal function. FASEB J 1996;10:4588.

Earnest CP, Snell PG, Rodriguez R, et al. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand 1995;153:207-9.

Felber S, Skladal D, Wyss M, et al. Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study. Neurol Res 2000;22:145-50.

Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutr Rev 1999;57:45–50.

Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in man. Am J Physiol 1996;271:E821–6.

Green AL, Simpson EJ, Littlewood JJ, et al. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 1996;158:195-202.

Greenhaff PL. Creatine and its application as an ergogenic aid. Int J Sport Nutr 1995;5:94-101.

Greenhaff PL. The nutritional biochemistry of creatine. J Nutr Biochem 1997;8:610-8 [review].

Greenhaff PL, Bodin K, Soderlund K, et al. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol 1994;266:E725-30.

Greenhaff PL, Casey A, Short AH, et al. Influence of oral creatine supplementation on muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci 1993;84:565-71.

Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 1992;83:367-74.

Hultman E, Soderlund K, Timmons J, et al. Muscle creatine loading in man. J Appl Physiol 1996;81:232–7.

Juhn MS, O’Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593–5.

Kreider RB, Ferreira M, Wilson M, et al. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc 1998;30:73-82.

Poortmans JR, Auquier H. Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol 1997;76:566–7.

Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108–10.

Pritchard NR, Kaira PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252–3 [letter].

Sewell DA, Robinson TM, Casey A, et al. The effect of acute dietary creatine supplementation upon indices of renal, hepatic and haematological function in human subjects. Proc Nutr Soc 1998;57:17A.

Silber ML. Scientific facts behind creatine monohydrate as a sports nutrition supplement. J Sports Med Phys Fitness 1999;39:179–88 [review].

Sipila I, Rapola J, Simell O, et al. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N Engl J Med 1981;304:867-70.

Stone MH, Sanborn K, Smith LL, et al. Effects of in-season (5-weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr 1999;9:146-65.

Stout JR, Eckerson J, Noonan D, et al. The effects of a supplement designed to augment creatine uptake on exercise performance and fat-free mass in football players. Med Sci Sports Exerc 1997;29:S251.

Tarnopolsky MA. Potential benefits of creatine monohydrate supplementation in the elderly. Curr Opin Clin Nutr Metab Care 2000;3:497-502 [review].

Tarnopolsky M, Martin J. Creatine monohydrate increases strength in patients with neuromuscular disease. Neurology 1999;52:854-7.

Tarnopolsky MA, Roy BD, MacDonald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 1997;20:1502-9.

Toler SM. Creatine is an ergogen for anaerobic exercise. Nutr Rev 1997;55:21-5 [review].

Vandenberghe K, Gills N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452–7.

Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol 1997;83:2055-63.

Walter MC, Lochmuller H, Reilich P, Klopstock T, Huber R, Hartard M, Hennig M, Pongratz D, Muller-Felber W. Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study. Neurology. 2000 May 9;54(9):1848-50. PMID: 10802796

Walter MC, Reilich P, Lochmuller H, Kohnen R, Schlotter B, Hautmann H, Dunkl E, Pongratz D, Muller-Felber W. Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study. J Neurol. 2002 Dec;249(12):1717-22. PMID: 12529796



--
Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=994)


In men under 65, prostate surgery can save lives.
TopPreviousNext

Date: July 27, 2005 03:32 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: In men under 65, prostate surgery can save lives.

10. In men under 65, prostate surgery can save lives.

When it comes to treating prostate cancer, one question prevails: To have surgery or not to have surgery? Since many cancers are slow growing, doctors often suggest that patients take a wait-and-see approach, opting to monitor tumor growth instead. While this gamble can pay off, those with faster-growing cancers may not be so fortunate. A new study, published in the New England Journal of Medicine, determined that when men under age 65 opt for surgery, the odds of surviving prostate cancer increase while chances of the cancer recurring decrease.

At a glance, the findings may seem to contradict research that urges men to watch and wait, but the study targeted patients with localized tumors large enough to be felt during a Manual rectal exam. Following radical prostatectomy, when surgeons remove the prostate, surrounding tissue and lymph nodes, cancer was less likely to spread locally or to distant sites. After 10 years, 19.2% of the men in the surgery group had local progression, compared to 44.3% in the watchful waiting group. Among the surgery group, 15.2% experienced distant cancer progression, while 25.4% of those who eschewed surgery had their cancer spread.

Now that you know the ins and outs of this complex but treatable disease, there’s really no good excuse to avoid getting regular screenings and following prevention guidelines. Being proactive about your prostate could save your life.



--
Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=709)


Urinary problems are a common sign that prostate cancer has advanced.
TopPreviousNext

Date: July 27, 2005 03:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Urinary problems are a common sign that prostate cancer has advanced.

9. Urinary problems are a common sign that prostate cancer has advanced.

In its early, most treatable stage, prostate cancer usually does not cause any symptoms. If prostate cancer develops and is not treated, however, symptoms can include difficult, frequent or painful urination; sexual problems; and pain or stiffness in the lower back, hips, or upper thighs. Following a PSA and a Manual exam, a physician should order an ultrasound and X-rays to determine the cause of the symptoms, according to the National Institutes of Health. To confirm the presence of cancer, needles are used to remove small tissue samples from the prostate. If a biopsy confirms cancer, a rating system called the Biopsy Gleason score is used to measure the aggressiveness of the cancer before a treatment plan is determined.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=708)


The benefits of a manual exam for prostate cancer far outweigh any embarrassment.
TopPreviousNext

Date: July 27, 2005 02:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The benefits of a Manual exam for prostate cancer far outweigh any embarrassment.

2. The benefits of a Manual exam for prostate cancer far outweigh any embarrassment.

While women routinely visit the GYN for yearly or even bi-yearly exams, many men find the idea of being examined so intimately to be disconcerting. “It’s not their favorite exam, but it’s not that painful,” admits Dr. E. Roy Berger, MD, FACP, Director of North Shore Prostate Cancer Consultation and Treatment Service at North Shore Hematology/Oncology Associates in East Setauket, New York. “There is no spectrum involved. It’s just a finger.” Education and understanding are the key to men overcoming their anxiety. It’s also an opportunity for women to reassure their significant others that this type of exam is vital to good health and a gratifying love life. “Patients should actually ask their primary care doctor for a digital rectal exam,” suggests Berger. “It’s a matter of mindset.”

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=701)


10 Things You Should Know About Prostate Cancer
TopPreviousNext

Date: July 27, 2005 02:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 10 Things You Should Know About Prostate Cancer

10 Things You Should Know About Prostate Cancer

If you were to compile a top ten list of things men would rather just avoid, prostate exams might even rate above taking out the garbage, doing dishes and going shopping. But there’s no good excuse to ignore this walnut-sized gland located between the bladder and the penis and in front of the rectum. Confused by the debate surrounding nearly ever aspect of prostate cancer and embarrassed to request a physical exam, many men ignore prostate health, only to discover that the benefits of screening far outweigh its risks. As women openly talk about breast and ovarian cancers, prostate health remains a difficult and controversial topic for men to discuss, forcing many to forgo the Manual exam that could lead to early detection and straightforward treatment. Though most males eventually develop some cancerous cells in their prostates, many prostate cancers develop so slowly that men often die of other causes. Indeed, it’s often said that most men die with prostate cancer, not from it. But the fact remains that prostate cancer kills more men who don’t smoke than any other cancer: The American Cancer Society reports that more than 232,000 men will be diagnoses with prostate cancer in 2005 and 30,350 will die from it. These statistics seem fairly overwhelming when you consider that one in six men will be diagnosed with prostate cancer in his lifetime, while one in eight American women will develop breast cancer in her lifetime. Despite the ongoing debate about whether the results of a prostate screening may cause unnecessary treatment, growing evidence suggests that testing for prostate cancer saves lives. The number of men who died of the disease fell by 26% from 1991 to 2001, with a five-year survival rate for men diagnosed with early-stage prostate cancer of nearly 100%; 10-year survival rates for all prostate cancer patients stand at 92%, while 15-year survival rates fell to 61%. Energy Times evaluated some of the key issues surrounding prostate cancer, including screening misconceptions, risk factors and lifestyle choices that can influence the likelihood of developing this potentially deadly disease. We hope they help you, or your significant other, make well-informed health decisions.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=699)


HERBAL FIRST AID KIT
TopPreviousNext

Date: July 11, 2005 09:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HERBAL FIRST AID KIT

HERBAL FIRST AID KIT

It is important to know the area where you will be going to determine plants that will be available in case they are needed and access to emergency help if necessary. The herbal first aid kit is meant to be used for minor conditions that may occur while traveling. Any serious condition should be seen by a health care professional. Gathering herbs along the trail can be fun as well as useful. Simple plant remedies can be brought along in the first aid kit. Major injuries require immediate medical attention by a professional. Minor problems can often be taken care of with simple herbal remedies. Supplies can be obtained from the local health food store or by collecting plants locally.

Along with the herbs, a few supplies should be part of the kit available at the local drugstore or market.


1. scissors
2. thermometer
3. band aids of all sizes
4. gauze
5. tweezers
6. blister kit
7. needle
8. moleskin for blisters
9. adhesive tape
10. first aid instruction Manual
11. herbal first aid Manual

ALOE VERA: Aloe is great for minor skin abrasions, burns and as a natural laxative. It is excellent to soothe and repair damage from a sunburn. Aloe can be applied to stings and bites to soothe and heal.

TEA TREE OIL: Tea tree oil is a natural antiseptic and contains many antibacterial, antifungal and antiviral properties. It helps to speed the healing process and is excellent to apply externally on wounds to promote healing and prevent infection. It is also a natural bug repellent and can soothe and promote healing after bites and stings.

ECHINACEA: One of the most often used herbs, echinacea is useful for pre venting infection by stimulating the immune function. It can be found in herbal salve preparations and applied directly to the wound. A salve can also be applied to skin irritations from contact with poison ivy or oak. LAVENDER: Lavender is a natural bug repellent and can be applied topically to bites and stings.

GINGER: Ginger root is excellent for an upset stomach. It is effective when used to combat motion and altitude sickness. Studies have found ginger to be just as effective when treating motion sickness due to riding in the car, boating or flying in and airplane, as over the counter remedies which often have side effects such as drowsiness. Ginger can be made into a tea or taken in capsule form. ARNICA: Arnica can be applied externally to areas of bruising and swelling, but not to broken skin. It can help to reduce inflammation.

PLANTAIN: A poultice of plantain can help reduce inflammation when applied to the affected area. It can also help with bites, stings, scratches and cuts. GARLIC: Along with being a natural antibiotic to help prevent infection, garlic also helps to keep mosquitoes away. They don’t seem to like the scent of garlic. Capsules or pills should be taken internally.

CAYENNE (CAPSICUM): This is effective for both internal and external bleeding. Externally, apply pressure and raise affected area. Sprinkle cayenne powder over the wound. MINT: Mint leaves, often found growing in the wild, can be made into a tea to help with digestion and calm the nerves. Some members of the mint family include peppermint, spearmint, catnip and horsemint.

FEVERFEW: This daisy like plant found growing in the wild, can help with migraine headaches and inflammation.

Chew the leaves, make into a tea or take in capsule form. Some have developed mouth irritations from chewing the leaves.

Tea Tree Oil Fights Staph Infection

There is much concern regarding the overuse of antibiotics leading to drug resistant strains of bacteria. Some forms of bacteria are difficult to control as they change form. Tea tree oil holds promise as an effective treatment for inactivating Staphylococcus aureus.

A study reported in the Journal of Antimicrobial Chemotherapy, (1995; 35: 421-45), and lead by Dr. C. F. Carson, researched tea tree oil at the University of Western Australia. The results were significant. Tea tree oil successfully inactivated the staph bacteria which was resistant to methicillin, a salt of penicillin. It is a versatile substance with a broad spectrum of capabilities. It is generally used topically.

Blueberries for Health

Blueberries are packed full of nutritional value. A study published in the Food and Nutrition Re s e a rch Br i e f s , January, 1997, found that two-thirds of a cup of blueberries had more antioxidants than the recommended daily amounts of vitamins E and C. Blueberries were followed by Concord grape juice, strawberries, kale and spinach in their antioxidant content.

Antioxidants are an important part of optimal health. They protect the body from free radical damage which can lead to a variety of conditions such as aging, cancer, heart disease and other diseases. Adding blueberries could aid in p rotecting the body and strengthening the immune response.

Worldwide Concern About Antibiotic Overuse

A recent report called for doctors throughout the world to be careful in administering antibiotics needlessly. Overuse of antibiotics has lead to germ mutations resistant and untreatable with current antibiotics. Pediatricians in the United States have received a brochure from the American Academy of Pediatrics urging them to take precautions before prescribing. Antibiotics are not always the answer as they do not work on viral infections which cause the common cold, sore throats and some ear infections. Staphylococcus aureus is one example of an antibiotic resistant strain. Over 90 percent of this staph strain are resistant to penicillin and other antibiotics. And other bacteria are also developing a resistance to antibiotic therapy. Save antibiotics for conditions that require their use.

Aloe Vera, Woodland Health Series

Aloe vera is one of the most widely used plants for medicinal purposes. It has been used for over 4,000 year for its therapeutic benefits. Aloe Vera, a pamphlet written by Deanne Tenney, offers valuable information and up to date research on the aloe vera plant.

The benefits of the aloe plant are truly amazing. It has been used to treat burns, radiation burns, skin disorders, wounds, scratches, sunburn, dermatitis, constipation, digestion, ulcer, kidney stones, bacterial and viral infections, and to relieve pain. It is widely used for skin disorders, but its benefits go far beyond the skin.

As a natural home remedy, there are few plants more valuable than the aloe. It is a simple and easy way to treat minor injuries. The plant contains antiseptic, antiviral, antibacterial, anesthetic and tissue healing properties. The Aloe Vera pamphlet offers historical as well as modern uses for this ancient plant. Aloe Vera is available through Woodland Publishing.

Tea Tree Oil, Woodland Health Series

Tea tree oil is derived from the leaves of the Melaleuca alternifolia, a shrub-like tree found in Australia. It contains significant medicinal value and beneficial properties. Another pamphlet in the Woodland Publishing Health Series, Tea Tree Oil offers historical uses as well as current scientific information.

The essential oil of the tea tree leaves is one of the most powerful essential oils. It is used extensively in Australia, and popularity is growing throughout the world. It contains antibacterial, antiviral, and antifungal properties helping to prevent and heal infection.

Tea tree oil has been used successfully for many conditions such as athlete’s foot, acne, burns, warts, vaginal yeast infections, ringworm, skin rashes, herpes, cold sores, canker sores, insect bites and in preventing infection to name a few. Tea tree oil is a natural alternative that can be used effectively for extended periods of time without.



--
Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=574)


HISTORY
TopPreviousNext

Date: June 23, 2005 10:53 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HISTORY

HISTORY

Known to the natives of the tropical Americas for millennia, Capsicum, or Cayenne Pepper, was introduced to Europe by Christopher Columbus and became known as “Guinea Pepper. ” Originally used by Native Americans located south of the Mexican border, archeological evidence supports its cultivation from 7000 B.C. Apparently, mixing chocolate and red chiles was a taste treat exclusively reserved for Aztec royalty.5 The exact origin of the word Capsicum remains somewhat of a mystery. However, it is assumed to be a derivative of the Greek word kapto, meaning “to bite,” an appropriate reference to its fiery pods. Capsicum is the fruit of a shrub-like tropical plant and is technically considered a berry. Its designation as a “pepper” can be traced back to Columbus, who equated its hot taste sensation with that of black pepper.

In 1597, Gerard referred to Capsicum as extremely hot and dry and prescribed it for throat and skin infections. Health practitioners of the nineteenth century called phsysiomedicalists used Capsicum to counteract rheumatism, arthritis, depression and chills. In the early 1800s, Dr. Samuel Thompson utilize d Capsicum as a potent and safe natural stimulant. His followe r s , who would become known as Thomsonians, believed that Capsicum should be used to treat a wide variety of diseases. It was used orally and as a poultice to treat tumors, toothaches, feve r s , and respiratory ailments.

In 1804, Dr. John St e vens introduced the red pepper to England where it became the catalyst component in a variety of herbal blends. Subsequently, herbal and medical practitioners used Capsicum to fight infection and sustain the natural heat of the body. It became well known in American dispensatories and pharmacopeia. In 1943, The Dispensary of the United States recorded that, “Capsicum is a powe rful local stimulant, producing when CAPSICUM swallowed, a sense of heat in the stomach and a general glow over the body without narcotic effect.”6 Twentieth-century physicians recognized the medicinal value of Capsicum which eventually found its way to the American Illust rated Medical Dictionary, the Merck Manual and Materia Medica, where it was referred to as a rubefacient, local stimulant, counter-irritant, gastric stimulant, and diaphoretic.7

Today Mexican Indians continue to use Capsicum as an internal disinfectant and protectant against contaminated food and also to treat fevers.8 “Today the pepper is nowhere in the world more appreciated and more widely used than in Mexico and certain other Latin American countries, which together form the original home of all the peppers. Both at morning and at evening, practically eve ry dish the Indians eat included Capsicum, just as their food did 2,000 years ago. The diet of the Indians was, and still is, rather bland . . . maize, beans, squash, pumpkin, yucca, potatoes . . . little wonder that the pepper was so highly regarded. And of course . . . the peppers were a wonderful source of essential vitamins in a diet otherwise lacking in them.”9 Capsicum continues to be a source of vitality and health in numerous countries including the Bahamas and Costa Rica, where it is used to overcome colic or indigestion, in Africa for vascular disorders and by North Americans who use it as a tonic and natural stimulant.

Capsicum is currently experiencing a renaissance in that a number of recent studies have emerged adding to its already impressive list of actions. Scientists are taking notice and looking at Capsicum with new respect and interest. Perhaps what sets Capsicum apart is that unlike powe rful pharmaceutical stimulants and pain killers, Capsicum possess potency without deleterious side effects.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=404)


Menopause: Disease or Condition?
TopPreviousNext

Date: June 13, 2005 03:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Menopause: Disease or Condition?

Menopause: Disease or Condition?

by Mary Ann Mayo & Joseph L. Mayo, MD Energy Times, September 4, 1999

It's front-page news. It's politically correct and socially acceptable. Talking about menopause is in. Suddenly it's cool to have hot flashes. Millions of women turning 50 in the next few years have catapulted the subject of menopause into high-definition prominence.

It's about time. Rarely discussed openly by women (what did your mother ever advise you?), meno-pause until recently was dismissed as "a shutting down experience characterized by hot flashes and the end of periods." Disparaging and depressing words like shrivel, atrophy, mood swings and melancholia peppered the scant scientific menopausal literature.

What a difference a few years and a very vocal, informed and assertive group of Baby Boomers make. Staggered by the burgeoning numbers of newly confrontational women who will not accept a scribbled prescription and a pat on the head as adequate treatment, health practitioners and researchers have been challenged to unravel, explain and deal with the challenges of menopause.

Not An Overnight Sensation

Menopause, researchers have discovered, is no simple, clear cut event in a woman's life. The "change of life" does not occur overnight. A woman's body may begin the transition toward menopause in her early 40s, even though her last period typically occurs around age 51. This evolutionary time before the final egg is released is called the perimenopause. Erratic monthly hormone levels produce unexpected and sometimes annoying sensations.

Even as their bodies adjust to lower levels of estrogen, progesterone and testosterone, some women don't experience typical signs of menopause until after the final period. A fortunate one-third have few or no discomforts.

Hormonal Events

According to What Your Doctor May Not Tell You About Premenopause (Warner Books) by John R. Lee, MD, Jesse Hanley, MD, and Virginia Hopkins, "The steroid hormones are intimately related to each other, each one being made from another or turned back into another depending on the needs of the body...But the hormones themselves are just part of the picture. It takes very specific combinations of vitamins, minerals and enzymes to cause the transformation of one hormone into another and then help the cell carry out the hormone's message. If you are deficient in one of the important hormone-transforming substances such as vitamin B6 or magnesium, for example, that too can throw your hormones out of balance. Thyroid and insulin problems, toxins, bad food and environmental factors, medication and liver function affect nutrient and hormone balance."

The most important reproductive hormones include:

Estrogen: the female hormone produced by the ovaries from puberty through menopause to regulate the menstrual cycle and prepare the uterus for pregnancy. Manufacture drops significantly during menopause. Estradiol is a chemically active and efficient form of estrogen that binds to many tissues including the uterus, breasts, ovaries, brain and heart through specific estrogen receptors that allow it to enter those cells, stimulating many chemical reactions. Estriol and estrone are additional forms of estrogen.

Progesterone: also produced by the ovaries, it causes tissues to grow and thicken, particularly during pregnancy, when it protects and nurtures the fetus. Secretion ceases during menopause.

Testosterone: Women produce about one-twentieth of what men do, but require it to support sex drive. About half of all women quit secreting testosterone during menopause.

Estrogen's Wide Reach

Since estrogen alone influences more than 400 actions on the body, chiefly stimulating cell growth, the effects of its fluctuations can be far-reaching and extremely varied: hot (and cold) flashes, erratic periods, dry skin (including the vaginal area), unpredictable moods, fuzzy thinking, forgetfulness, fatigue, low libido, insomnia and joint and muscle pain.

Young women may experience premature menopause, which can occur gradually, as a matter of course, or abruptly with hysterectomy (even when the ovaries remain) or as a result of chemotherapy. Under such conditions symptoms can be severe.

In the 1940s doctors reasoned that if most discomforts were caused by diminishing estrogen (its interactive role with progesterone and testosterone were underestimated), replacing it would provide relief. When unchecked estrogen use resulted in high rates of uterine cancer, physicians quickly began adding progesterone to their estrogen regimens and the problem appeared solved.

For the average woman, however, hormone replacement therapy (HRT) became suspect and controversial, especially when a link appeared between extended use of HRT (from five to 10 years) and an increase in breast and endometrial cancers (Journal of Clinical Pharmacology 37, 1997). The result: Women have drawn a line in the sand between themselves and their doctors.

Resolving The Impasse

Since hormone replacement reduces the risk of major maladies like heart disease, osteoporosis, Alzheimer's, colon cancer and diabetes that would otherwise significantly rise as reproductive hormone levels decrease, most doctors recommend hormone replacement shortly before or as soon as periods stop. Hormone replacement also alleviates the discomforts of menopause.

But only half of all women fill their HRT prescriptions and, of those who do, half quit within a year. Some are simply indifferent to their heightened medical risks. Some are indeed aware but remain unconvinced of the safety of HRT. Others complain of side effects such as bloating, headaches or drowsiness.

Women's resistance to wholesale HRT has challenged researchers to provide more secure protection from the diseases to which they become vulnerable during menopause, as well as its discomforts. If the conventional medical practitioners do not hear exactly what modern women want, the complementary medicine community does. Turning to centuries-old botanicals, they have validated and compounded them with new technology. Their effectiveness depends on various factors including the synergistic interaction of several herbs, specific preparation, the correct plant part and dosage, harvesting and manufacturing techniques.

Research demonstrates that plant hormones (phytoestrogens) protect against stronger potentially carcinogenic forms of estrogen while safely providing a hormone effect. Other herbs act more like tonics, zipping up the body's overall function.

Help From Herbs

Clinical trials and scientific processing techniques have resulted in plant-based supplements like soy and other botanicals that replicate the form and function of a woman's own estrogen.

The complementary community also can take credit for pushing the conventional medical community to look beyond estrogen to progesterone in postmenopausal health.

Natural soy or Mexican yam derived progesterone is formulated by pharmacologists in creams or gels that prevent estrogen-induced overgrowth of the uterine lining (a factor in uterine cancer), protect against heart disease and osteoporosis and reduce hot flashes (Fertility and Sterility 69, 1998: 96-101).

A quarter of the women who take the popularly prescribed synthetic progesterone report increased tension, fatigue and anxiety; natural versions have fewer side effects.

These "quasi-medicines," as Tori Hudson, a leading naturopathic doctor and professor at the National College of Naturopathic Medicine, Portland, Oregon, calls them, are considered "stronger than a botanical but weaker than a medicine." (Hudson is author of Gynecology and Naturopathic Medicine: A Treatment Manual.)

According to Hudson, the amount of estrogen and progesterone in these supplements is much less than medical hormone replacement but equally efficacious in relieving menopausal problems and protecting the heart and bones.

According to a study led by Harry K. Genant, PhD, of the University of California, San Francisco, "low-dose" plant estrogen derived from soy and yam, supplemented with calcium, prevents bone loss without such side effects as increased vaginal bleeding and endometrial hypoplasia, abnormal uterine cell growth that could be a precursor to endometrial cancer (Archives of Internal Medicine 157, 1997: 2609-2615).

These herbal products, including natural progesterone and estrogen in the form of the weaker estriol or estrone, may block the effect of the stronger and potentially DNA-damaging estradiol.

Soy in its myriad dietary and supplemental forms provides a rich source of isoflavones and phytosterols, both known to supply a mild estrogenic effect that can stimulate repair of the vaginal walls (Journal of the National Cancer Institute 83, 1991: 541-46).

To enhance vaginal moisture, try the herb cimicifuga racemosa, the extract of black cohosh that, in capsule form, builds up vaginal mucosa (Therapeuticum 1, 1987: 23-31). Traditional Chinese herbal formulas containing roots of rehmannia and dong quai have long been reputed to promote vaginal moisture.

Clinical research in Germany also confirms the usefulness of black cohosh in preventing hot flashes and sweating, as well as relieving nervousness, achiness and depressed moods caused by suppressed hormone levels. It works on the hypothalamus (the body's thermostat, appetite and blood pressure monitor), pituitary gland and estrogen receptors. Green tea is steeped with polyphenols, mainly flavonoids, that exert a massive antioxidant influence against allergens, viruses and carcinogens. The risks of estrogen-related cancers such as breast cancer are particularly lowered by these flavonoids, as these substances head directly to the breast's estrogen receptors. About three cups a day exert an impressive anti-inflammatory, antiallergenic, antiviral and anticarcinogenic effect.

Other phytoestrogen-rich botanicals, according to Susun Weed's Menopausal Years: The Wise Woman Way (Ash Tree Publishing), include motherwort and lactobacillus acidophilus to combat vaginal dryness; hops and nettles for sleep disturbances; witch hazel and shepherd's purse for heavy bleeding; motherwort and chasteberry for mood swings; dandelion and red clover for hot flashes.

Our Need For Supplements

Adding micronutrients at midlife to correct and counter a lifetime of poor diet and other habits is a step toward preventing the further development of the degenerative diseases to which we become vulnerable. At the very minimum, you should take:

a multivitamin/mineral supplement vitamin E calcium

Your multivitamin/mineral should contain vitamins A, B complex, C, D, E, calcium, magnesium, potassium, copper and zinc. Look for a wide variety of antioxidants that safeguard you from free radical damage, believed to promote heart disease and cancer, as well as contribute to the aging process.

Also on the list: mixed carotenoids such as lycopene, alpha carotene and vitamin C; and folic acid to help regulate cell division and support the health of gums, red blood cells, the gastrointestinal tract and the immune system.

Studies indicate a deficiency of folic acid (folate) in 30% of coronary heart disease, blood vessel disease and strokes; lack of folate is thought to be a serious risk factor for heart disease (OB.GYN News, July 15, 1997, page 28).

Extra vitamin E is believed to protect against breast cancer and bolster immune strength in people 65 and older (Journal of the American Medical Association 277, 1997: 1380-86). It helps relieve vaginal dryness, breast cysts and thyroid problems and, more recently, hit the headlines as an aid in reducing the effects of Alzheimer's and heart disease. It is suspected to reduce the thickening of the carotid arterial walls and may prevent the oxidation of LDL (bad) cholesterol, which contributes to the formation of plaque in arteries.

Selenium also has been identified as an assistant in halting cancer (JAMA 276, 1996: 1957-63).

The Omegas To The Rescue

Essential fatty acids found in cold water fish, flaxseed, primrose and borage oils and many nuts and seeds are essential for the body's production of prostaglandin, biochemicals which regulate hormone synthesis, and numerous physiological responses including muscle contraction, vascular dilation and the shedding of the uterine lining. They influence hormonal balance, reduce dryness and relieve hot flashes.

In addition, the lignans in whole flaxseed behave like estrogen and act aggressively against breast cancer, according to rat and human studies at the University of Toronto (Nutr Cancer 26, 1996: 159-65).

Research has demonstrated that these omega-3 and omega-6 fatty acids can reverse the cancer-causing effects of radiation and other carcinogens (Journal of the National Cancer Institute 74, 1985: 1145-50). Deficiencies may cause swelling, increased blood clotting, breast pain, hot flashes, uterine and menstrual cramps and constipation. Fatigue, lack of endurance dry skin and hair and frequent colds may signal EFA shortage. Plus, fatty fish oils, along with vitamin D and lactose, help absorption of calcium, so vital for maintaining bone mass.

In addition, studies show that the natural substance Coenzyme A may help menopausal women reduce cholesterol and increase fat utilization (Med Hyp 1995; 44, 403, 405). Some researchers belive Coenzyme A plays a major role in helping women deal with stress while strengthening immunity.

Still Suffering?

Can't shake those menopausal woes? Menopause imposters may be imposing on you: The risk of thyroid disease, unrelenting stress, PMS, adrenal burnout, poor gastrointestinal health and hypoglycemia all increase at midlife. Menopause is a handy hook on which to hang every misery, ache and pain but it may only mimic the distress of other ailments. For this reason every midlife woman should have a good medical exam with appropriate tests to determine her baseline state of health. Only with proper analysis can you and your health practitioner hit on an accurate diagnosis and satisfying course of therapy.

And if menopause is truly the issue, you have plenty of company. No woman escapes it. No woman dies from it. It is not a disease but a reminder that one-third of life remains to be lived. Menopausal Baby Boomers can anticipate tapping into creative energy apart from procreation. If not new careers, new interests await. An altered internal balance empowers a menopausal woman to direct, perhaps for the first time, her experience of life. She has come of age-yet again. Gone is the confusion, uncertainty, or dictates of a hormone driven life: This time wisdom and experience direct her. There is no need to yearn for youth or cower at the conventional covenant of old age. Menopause is the clarion call to reframe, reevaluate and reclaim.

Mary Ann Mayo and Joseph L. Mayo, MD, are authors of The Menopause Manager (Revell) and executive editors of Health Opportunities for Women (HOW). Telephone number 877-547-5499 for more information.



--
Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=330)


Allergy Alleviation
TopPreviousNext

Date: June 10, 2005 05:32 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Allergy Alleviation

Allergy Alleviation by Cal Orey , February 2, 2002

Allergy Alleviation By Cal Orey

Welcome to the stuffed up world of seasonal allergic rhinitis: the wheezing, sneezing "inhalant allergies" that torment 35 million Americans. Adding insult to sinus pain, other allergens attack year-round. Air pollution, dust mites (microscopic gremlins that infest bedding, upholstery and rugs) and animal dander trigger allergies-or other respiratory ailments-in any season. Urban air is full of rubber tire particles, a true blowout for those with latex sensitivity. Altogether, roughly 50 million Americans-about one in five-suffer from some form of allergy, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Tired of cross-pollinating with plants or being bowled over by dust balls? Vitamins, herbs and other nutrients can help you nip allergy discomfort in the bud.

The Allergy Response

Your immune system triggers an allergic response when it overreacts to otherwise harmless substances or antigens (we're talking dust, pollen and mold).The alarmed immune system then launches a defensive chemical reaction, releasing potent chemicals (antibodies) supposed to destroy the "invaders." The antibodies, called IgE, carry the invading substances to special cells, which zap them with more biochemicals. Among these protective cells are mast cells: they release histamine, the substance that causes swelling and inflammation to the linings of the nose, sinuses and eyelids, resulting in sneezing, upper respiratory congestion and itchy, watery eyes.

Just Blame The Folks

Most allergies are determined by your genes. If your Mom or Dad sneeze and scratch, there's a good chance you will, too. "That is not to say that we directly inherit an allergy to any specific substance. Rather, it seems as if we might inherit some kind of immune system defect or weakness that leaves us more vulnerable to allergies," explain co-authors Glenn S. Rothfeld, MD, and Suzanne LeVert in their book Natural Medicine for Allergies: The Best Alternative Methods for Quick Relief (Rodale). For some people, allergies lurk in food, throwing the immune system into overdrive. "Many natural medicine practitioners believe that a diet high in animal fats will contribute to the development of allergy and asthma, as does a diet high in food additives, such as preservatives and dyes," says Gary McLain, PhD, in his book The Natural Way of Healing: Asthma and Allergies (Dell). Worse, allergies can up the risk of asthma, which afflicts 15 million Americans. Most people afflicted with asthma also suffer allergies: the two are linked, according to the AAAAI. Allergy triggers of asthma include pollen, mold spores and house dust mites. Remember Helen Hunt's asthmatic son in the movie As Good As It Gets? His character endured allergies to dust, and living in New York (and watching his mom date Jack Nicholson) didn't help his immune system. Coughs, ear infections, fevers and visits to hospital emergency rooms curtailed his social life (and limited his close-ups as well). That kind of routine happens in real life, too. (Well, maybe close encounters with Jack N. are not included for most.) But when we breathe substances such as molds, they can induce swelling and inflammation of the bronchial airways which narrow and restrict air flow. This, in turn, causes wheezing and shortness of breath and can trigger an asthma "attack," according to Andrew Engler, MD, who specializes in allergy and asthma in San Mateo, California.

The Nose Knows: Chemical Sensitivities

Imagine a picture-perfect, crisp, clear Saturday morning. You make a final stop on your weekly errand run to the dry cleaner, where you drop off your laundry and spend a moment chatting up the owner. Back in your car, your eyes tear and you feel a bit woozy. Kenneth Bock, MD, and Nellie Sabin, writing in The Road to Immunity: How To Survive and Thrive in a Toxic World (Pocket Books) sense that your reaction could be chemical sensitivity, a difficult to diagnose but, in their opinion, very real malady. (Of course, a clinician can test you for immune responses to certain chemicals.) Reactions to chemicals produce the typical allergic responses: puffy or red-rimmed eyes; swelling; aching or stiff joints and muscles; irritability or dizziness; respiratory inflammations; headaches and the like. Villains include aerosol sprays, tobacco smoke, glues, insecticides and herbicides, household chemicals and fragrances. Identification and avoidance are key, say the authors. Vitamin C, which binds with chemicals, is one of the best nutritional defenses.

Breathing Problems Expand

Americans now freely take lifesaving medicines such as antibiotics and insulin but, in some people, "they have the potential to alter the immune system, which is where allergies begin," says Dr. McLain. (Consult your pharmacist if you have questions about your prescription medication.) We, as a nation, are also eating more chemicals, from the pesticides drenched on plants to the preservatives poured on prepared foods. We're breathing polluted air, which can lead to or exacerbate asthma, and then we choke on recycled air in sealed buildings. And while a century ago you were likely to have spent much of your time close to home, you can now hop on a supersonic plane and be taken to the other side of the globe within a matter of hours. With travel comes exposure to even more exotic allergens that can drive your immune system to distraction.

The All-Natural Gesundheit

Certain allergy-relief nutrients and herbs can help make life more bearable. Here's how they work: n Vitamin C for the lungs. According to experts, when vitamin C is low, asthma is high. Vitamin C carries the major antioxidant load in the airways and therefore contributes mightily to the health of the lungs. A study in the Annals of Allergy (73(1994):89-96) reported that in seven of 11 clinical trials since 1973, vitamin C supplementation provided "significant improvements" in respiratory function and asthma symptoms. n Vitamin E and carotene to suppress allergic reactions. These antioxidants may also help protect the respiratory tract from caustic pollutants. Vitamin E is reputed to be one of the most important nutrients for antioxidant protection in the lungs. In addition, these two substances decrease production of allergy-related compounds called leukotrienes. n Zinc for the immune system. Research shows that a deficiency in this trace mineral can weaken your immune system, setting you up as a target for allergies and infections. (Some vegetarians may not store sufficient amounts of this mineral and should take supplements.) Zinc comes to the body's rescue by taking part in the production of IgA, the gastrointestinal antibody that lines the digestive tract. "When IgA binds to an allergen, it keeps it from being absorbed into the bloodstream and thus from causing an allergic reaction," report Rothfeld and Levert. Also, zinc protects mucous membranes and helps convert beta carotene to vitamin A, another anti-allergy, immune-boosting nutrient. In a study of 100 participants at the Cleveland Clinic Foundation, half took a zinc-based lozenge, while the other half received a dummy preparation. The participants taking zinc experienced a 42% reduction in the duration and severity of their common colds (Annals of Internal Medicine, 7/96). n Quercetin as an antihistamine. A valuable, anti-allergic flavonoid (plant coloring agent that is a powerful antioxidant), quercetin shines as a potent weapon against allergies and asthma. Believed to inhibit histamine release from mast cells and slow the production of other allergy-related compounds, it stabilizes mast cell membranes. Other flavonoid-rich extracts include grape seed, pine bark, green tea and Ginkgo biloba. n Additional helpful nutrients: Vitamin B-12, particularly to combat sensitivity to sulfites (The Nutrition Desk Reference [Keats]); selenium, an antioxidant that breaks down leukotrienes (Clinical Science 77, 1989: 495-500); and magnesium to relax bronchial tissues (Journal of the American Medical Association, 262 [1989]: 1210-3).

Herbal Remedies To The Rescue

n Nettles for hay fever relief. Research at the National College of Naturopathic Medicine in Portland, Oregon, showed that 40 of 69 folks suffering from hay fever found moderate to extreme relief from taking freeze-dried stinging nettles (Planta Medica, [1990] 44-47). "It is nontoxic, cheap and preferable to antihistamines, which I think are significantly toxic," reports Andrew Weil, MD, in his book Natural Health, Natural Medicine: A Comprehensive Manual for Wellness and Self-Care (Houghton Mifflin). n Cayenne to reduce inflammation. Cayenne, known as hot red pepper, is rich in capsaicin, a potent flavonoid "counter-irritant" that dilates and soothes inflamed nasal and bronchial tissues, according to experts. A bonus: Cayenne also contains a rich amount of antioxidant vitamin C, which can help enhance your immune system. n Echinacea for allergy prevention. This popular Native American herb provides cold and allergy protection, particularly when you take it before encountering allergens. Studies reveal that echinacea aids your body's tissues and protects you from germs and allergens. In fact, German studies have found it possesses valuable antiviral, antibacterial and immunity-boosting properties.

Make Your World Allergy-Free

For the most effective allergy relief, make sure you stay clear of allergens that wreak allergy havoc. Visit an allergy-savvy health practitioner and get tested to find out which substances rock your respiratory world. Plus, allergy experts recommend: n Banish dust mites: sweep out clutter and have your house power-vacuumed, if necessary; wash bedding and linens in very hot water. n De-pollinate your environment: flip on the air conditioner to sift out pollen (keep its filter and any forced air registers clean); exercise indoors; machine dry, rather than line dry, your clothes. n Buy a home air filter, especially if you experience dust, pollen or pet dander allergies. n Avoid allergy triggers that dog your days: cats and canines (or consider the hairless or shed-less breeds), mold and tobacco smoke. No matter what you do or actions you take, allergies may always remain an annoyance in your life. But attention to the foods you eat, the places where you exercise and the right combination of anti-allergy nutrients can limit your discomfort.

Leveling The Leukotrine Playing Field

On a microscopic level, a series of biochemicals implicated in allergic reactions are leukotrienes, substances that may constrict the bronchial tubes (breathing passages). In some people, consuming the food additive tartrazine can cause severe asthmatic breathing difficulties by boosting leukotrine release. In turn, this can interfere with the body's use of vitamin B-6. The process in which lack of B-6 or "errors" in how your body uses B-6 causes allergic reactions and is complex. According to Michael Murray, ND and Joseph Pizzorno, ND in the revised edition of the Encyclopedia of Natural Medicine (Prima), breathing problems may begin when the metabolism of tryptophan (an amino acid) goes awry: "Tryptophan is converted to serotonin, a compound that, among other things, can cause the airways of asthmatics to constrict...Vitamin B-6 is required for the proper metabolism of tryptophan." Accordingly, a study of vitamin B-6, published in the American Journal of Clinical Nutrition, shows that people with compromised breathing may possess less B-6 in their blood than others who breathe normally. When people with asthma were given B-6, their wheezing and asthmatic attacks dropped.

Fat Fix For Allergies

The fat in your diet or supplements can also influence your susceptibility to allergies and asthma linked to allergies. Epidemiologists have found that countries where children eat fish at least four times a month cut their risk of asthma by 67% compared to other parts of the world where they consume fewer fish. Research on omega-3 fatty acids, the kind of fat found in fish, flax and hemp oil, demonstrates that some of these substances can improve breathing. In particular, fatty acids called eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can help open up bronchial tubes. Studies in the American Review of Respiratory Disease and the International Archives of Allergy and Applied Immunology show that breathing passageways may not react so negatively to the presence of allergens when you eat more fish or take supplements containing these types of fats. Many of the scientists who study the kinds of fats we eat believe that the increase in allergies and asthma in the US during the twentieth century may be due to both increasing air pollution (which irritates our lungs) plus a simultaneous increase in our consumption of what are called omega-6 fatty acids. Omega-6 oils are contained in most of the vegetable oils Americans eat, including sunflower and peanut oils. While experts believe that we would be better off consuming a diet containing about five times as many omega-6 fatty acids as omega-3s, today we eat about 40 times as much omega-6s. The chemistry of how these fats influence our allergy susceptibility is complex. It begins in our cell membranes which consist mostly of fat. When we consume omega-3 fatty acids, in our diet or in supplements, and these fats enter cell membranes, the change in structure cuts the availability of arachidonic acid, a fatty acid your body can make and which is found in meat, eggs and dairy products. Eventually, it is thought that this change in cellular metabolism and reduction in arachidonic acid forces the body to make less 4-series leukotrienes, substances which are quite prone to provoking allergic inflammation and, instead, produce 5-series leukotrienes, leukotrienes which don't cause nearly as much trouble. This process requires patience. According to Pizzorno and Murray. "It may take as long as one year before the benefits are apparent, as it appears to take time to turn over cellular membranes in favor of the omega-3 fatty acids."

Chinese Medicine Versus Allergies

Traditional Chinese Medicine (TCM) views allergies as an imbalance of the liver, says Jason Elias, co-author with Katherine Ketcham of The Five Elements of Self-Healing (Harmony Books). "The average American's (liver) deals with about fourteen pounds of chemicals a year. What would normally be a minor irritant becomes major because the liver can't process them anymore," explains Elias. Licorice root (Glycyrrhiza glabra) has traditionally been used to fight allergies since this herb battles inflammation as evidenced by Japanese research and a study published in the journal Allergy. Much of this anti-allergy action is thought to proceed from licorice's interaction with a biochemical called cortisol, a hormone secreted by the adrenal glands. Cortisol (along with epinephrine, another adrenal hormone) relaxes the muscles controlling airways. By slowing the liver's breakdown of cortisol, licorice prolongs circulation of this hormone which, in turn, can help breathing passages stay clear. In addition, glycyrrhetinic acid, a compound in licorice, slows the body's manufacture of prostaglandins and leukotrienes, substances which exacerbate allergic inflammatory reactions. Ma Huang (Ephedra sinica) has been employed for thousands of years to aid breathing since chemicals in this plant widen breathing passages.

Homeopathic Remedies for Allergy

Homeopathic treatments consist of highly diluted substances designed to coax the body into healing itself. The effectiveness of homeopathy for hayfever has been demonstrated by research published in Lancet performed at the University of Glasgow, Scotland. There, scientists showed that homeopathically-prepared medicines produced statistically significant improvements in allergy sufferers. The appropriate homeopathic remedy for any illness depends on the personality type of the person suffering an allergy. These treatments are among those recommended by Dana Ullman: n Allium cepa: appropriate for burning nasal discharge that grows worse in warm rooms and improves outdoors. Relieves non-burning tearing from eyes, raw feeling in the nose with tingling sensation and violent sneezing. n Nux vomica: used when feeling irritable and chilled, with daytime fluent nasal discharge and night congestion that grows worse indoors. Also for those sensitive to cold and to being uncovered. n Pulsatilla: best for women and children with daytime nasal discharge and night congestion who are gentle, yielding, mild, impressionable and emotional. Used when congestion is worse in warm rooms, hot weather or while lying down.

Food Allergy Conundrum Food allergies can prove to be the toughest allergies to identify and eliminate. Jason Elias believes that people may develop food sensitivities from eating the same foods too often. "If someone has an allergy, I might say 'Let's get you off dairy for three weeks,'" he says, noting that some people have limited their hay fever problems by ceasing to consume dairy products. Many have also found relief by maintaining a food diary, keeping track of which foods are associated with allergy attacks and then eliminating those foods. So the next time you sneeze, don't just reach for your hanky, think back to the meal that you just ate. Your allergy problem may be sitting in your stomach as well as making you sneeze and stuffing your sinuses. Taking these kinds of anti-allergy preventive measures can provide life-enhancing relief that feels like a godsend. That lets you attain your healthy best.

This article included reporting by Judy Pokras.



--
Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=278)


AMINO ACIDS AND PROTEIN
TopPreviousNext

Date: June 09, 2005 09:48 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: AMINO ACIDS AND PROTEIN

Amino Acids

AMINO ACIDS AND PROTEIN

Next to water, protein is the most abundant substance in the human body. Complex mega-molecules of protein are the structural building blocks of tissue. The thousands of different proteins in our bodies are composed of 20 molecules called amino acids. In the last 20 years, research has shown the benefits of amino acid supplementation to such diverse areas of human biochemistry as metabolism, enzyme and neurotransmitter production and antioxidant protection. Source Naturals utilizes the latest-breaking research to bring you a highly comprehensive line of amino acid supplements.

Amino Acids

DNA provides the instruction Manual for life, RNA reads the Manual and the genetic information is expressed by proteins. Proteins are the most abundant macromolecules in living cells constituting 50% or more of their dry weight. They create the structure of our cells and tissues, and play an essential role in virtually all of the biochemical events that animate those tissues.

The term "protein" refers to a set of macromolecules that encompasses an extensive variety of structure and function&endash;from helical rods with the tensile strength of steel to elastic sheets to huge molecular machines with hinged jaws that snap closed to hold other molecules in place. Amazingly, all proteins, in their remarkable variety, are built out of a set of 20 simple molecules called amino acids.

Amino acids are one of the four types of small molecules out of which all life is constructed. The other three are: palmitic acid (see "Essential Fatty Acids," page #), adenine and glucose. All amino acids share a common chemical "backbone" which consists of an a -carbon atom to which four substituent groups are bonded: a nitrogen-containing amino group (H2N), a carboxyl group (COOH), a hydrogen atom and an "R" group. The "R" group or side chain (figure #) varies in electric charge, size, structure and solubility in water, giving each amino acid its distinct chemical properties. Since all amino acids (except glycine) contain at least one asymmetrical carbon atom, each one exists in at least two forms: the l form and its mirror image or stereoisomer, the d form. While both forms are found in biological systems, only the l form is present in proteins.

Amino acids are linked together like beads on a string to form proteins, sometimes called peptides because of the peptide bonds that link the amino acids together. They range in size from simple two-amino-acid dipeptides to polypeptides which contain more than 1800 connected amino acids. The chemical backbone of the amino acids and their sequence constitutes the primary structure of a protein. Polypeptide chains then fold into specific 2 and 3-dimensional configurations that are unique for each type of protein. The pattern of folds, along with the chemical nature of the amino acid side chains contained in it, give a protein its characteristic biological activity. For example, the connective tissue proteins collagen and elastin give structure to cellular organelles and tissues, while proteins called enzymes catalyze and facilitate metabolic chemical reactions.

Nine of the 20 amino acids involved in protein synthesis are considered "essential";they cannot be synthesized by the body and must be obtained from food sources. The term "non-essential" is sometimes used to classify the other eleven amino acids. However, this word is perhaps a misnomer; a better term might be synthesizable. These amino acids are just as vital to human metabolism as the "essential" amino acids; so vital that the body can synthesize them. They are, however, more available, more versatile, and more interchangeable.

When the presence or absence of a particular amino acid will determine whether a protein can be created or not, that amino acid is called a rate-limiting factor for that protein. For example, the tripeptide glutathione, a compound that forms an important part of the body's protective mechanisms, is made of the amino acids glutamic acid, glycine and cysteine. Glutamic acid and glycine tend to be plentiful in the diet, and can be easily interconverted. Cysteine is the rate-limiting factor for glutathione; the amount of cysteine in the diet will determine the amount of glutathione that can be manufactured by the body.

Amino acids have a special role to play in brain nutrition, because all neurotransmitters are derived from amino acids or related compounds such as choline. Brain neurotransmitters, specifically, are biochemical keys to the workings of the mind. They are substances that perform chemical transmission of nerve impulses between neurons or between neurons and other cell types such as muscle. They work in the following way: an electric current (or action potential) travels down the length of a neuron, or nerve cell, until it reaches the synapse - a narrow gap between two cells. The incoming nerve impulse triggers the release of neurotransmitter (NT) molecules, which diffuse across the synaptic gap. The neurotransmitter molecules bind with receptor proteins embedded in the membrane of the post synaptic neuron and activate a physiological response. Excitatory neurotransmitters propagate a new action potential while inhibitory NT's inhibit the development of new action potentials.

The amino acid precursors of neurotransmitters are able to cross the blood-brain barrier, a structural feature of brain anatomy that prevents many substances from contacting brain tissue. Thus, it is possible to influence brain metabolism (and therefore emotional states) through the mechanism of neurotransmitter synthesis. The enhancement of neurotransmitter production is one of the most exciting advancements to occur in the field of nutrition in modern times.

A major portion of the amino acid requirement in humans is derived from the proteins in food. Successive proteolytic enzymes attack the peptide bonds, cleaving one amino acid at a time from the polypeptide chain. Ultimately, free amino acids as well as small peptides (especially dipeptides) are absorbed through the mucosal cells of the small intestine. The small peptides are then further hydrolyzed so that only free amino acids enter the liver and portal vein. This sounds like a fairly straightforward process. However, the presence of a particular amino acid profile in a certain food does not guarantee the assimilation of those amino acids when the food is ingested. There are three types of amino acids: acidic, basic and neutral; each of these classes has a different transport mediator. Therefore, there is competition for the carrier between any two amino acids in a certain class, both in the digestive tract and at the blood-brain barrier. Thus, the isolation of "free-form" amino acids is an important aid to nutritional engineering. In many cases, the consumption of high potencies of a particular amino acid allows that nutrient to overwhelm the competition for absorption. The resulting increase in blood and tissue levels will yield the benefits conferred by that nutrient.

The isolation of free-form amino acids is an important advancement in the field of nutrition science. Amino acid supplements offer a broad range of choices to complement your nutritional program.



--
VitaNet ®
VitaNEt ® Staff

Solaray - Ultimate Nutrition - Actipet Pet supplements - Action Labs - Sunny Greens - Thompson nutritional - Natural Sport - Veg Life Vegan Line - Premier One - NaturalMax - Kal

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=253)


Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...
TopPreviousNext

Date: May 24, 2005 09:52 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...

Cognitive Improvement in Mild to Moderate Alzheimer's Dementia After Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Maria De Jesus Moreno Moreno, MD Instituto Nacional de la Senectud, Mexico City, Mexico


This study assessed the efficacy and tolerability of the cholinergic precursor choline alfoscerate (CA) in the treatment of cognitive impairment due to mild to moderate AD (Alzheimer's disease).

in both men and woman they consistently improved after 90 and 180 days versus baseline with adiministration of GPC three times a day, whereas in the placebo group they remained unchanged or worsened. Statistically significant differences were observed between treatments after 90 and 180 days.

Keypoints:

  • improved cognition and global function
  • showed a statistically significant improvement after 90 and 180 days of treatment
  • Increased neurotransmission
  • With out treatment men and woman declined consistantly
  • references:

    Bartus RT, Dean RL III, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction, Science. 1982;217:408-414. 2. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: Dementia and Alzheimer's disease. Annu Rev Public Health. 1992;13:431-449. 3. Hofman A, Rocca WA, Brayne C, et al, for the European Prevalence Research Group. The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int d Epidemiol. 1991;20:736-748. 4. Blackwood W, Corsellis JAN, eds. Greenfield's Neuropathology. 3rd ed. London: Arnold; 1976. 5. Geldmacher DS. Cost-effective recognition and diagnosis of dementia. 5emin Neurol. 2002;22:63-70. 6. Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. BMJ. 1978;2:1457-1459. 7. Perry EK. The cholinergic hypothesis--ten years on. Br Med Bull. 1986;42:63-69. 8. Giacobini E. From molecular structure to Alzheimer therapy. Jpn d Pharmacol. 1997;74:225-241. 9. Giacobini E. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications. Neurochem Int. 1998;32:413-419. 10. Brinkman SD, Smith RC, Meyer JS, et al. Lecithin and memory training in suspected Alzheimer's disease. J Gerontol. 1982;37:4-9. 11. Davis E, Emmerling MR, Jaen JC, et al. Therapeutic intervention in dementia. Crit Rev Neurobiol. 1993;7:41-83. 12. Amenta E Parnetti L, Gallai V, Wallin A. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropiate approaches? Mech Ageing Dev. 2001;122:2025-2040. 13. Sigala S, Imperato A, Rizzonelli P, et al. k-Alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eurd Pharmacol. 1992;211:351-358. 14. Govoni S, Battaini E Lucchi L, et al. Effects of alpha-glycerylphosphorylcholine in counteracting drug-induced amnesia: Through cholinergic and non-cholinergic mechanisms [in Italian]. Basi Raz Ter. 1991;21:75-78. 15. Canonico PL, Nicoletti F, Scapagnini U. Neurochemical and behavioral effects of alpha-glycerylphosphorylcholine [in Italian]. Basi Raz Te~ 1990;20: 53-54. 191 CLINICAL THERAPEUTICS ® 16. Parnetti L, Amenta E Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: An analysis of published clinical data. Mech Ageing Dev. 2001;122:2041-2055. 17. Venn RD. The Sandoz Clinical Assessment-Geriatric (SCAG) scale. A general-purpose psychogeriatric rating scale. Gerontology. 1983;29:185-198. 18. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991;19:330-341. 19. Frattola L, Piolti R, Bassi S, et al. Multicenter clinical comparison of the effects of choline alphoscerate and cytidine diphosphocholine in the treatment of multi-infarct dementia. Curt Ther Res Clin Exp. 1991;49:683-693. 20. Muratorio A, Bonuccelli U, Nuti A, et al. A neurotropic approach to the treatment of multi-infarct dementia using L-c~-glycerylphosphorylcholine. Curt Ther Res Clin Exp. 1992;52:741-75l. 21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: APA; 1994. 22. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944. 23. Folstein ME Folstein SE. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198. 24. Loeb C, Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke. 1983;14:399-401. 25. Hamilton M. A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960;23:56-62. 26. Hamilton M. Development of a rating scale for primary depressive illness. BrJ Soc Clin Psych& 1967;6:278-296. 27. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. AmJ Psychiatry. 1984;141:1356-1364. 28. Reisberg B, Ferris SH, De Leon MJ, et al. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136-1139. 29. National Institute of Mental Health. Clinical global impressions. In: Guy W, ed. ECDEU Assessment for Psychopharmacology. Revised edition. Rockville, Md: National Institute of Mental Health; 1976:217-222. 30. Burns A, Russell E, Page S. New drugs for Alzheimer's disease. Br J Psychiatry. 1999;174:476-479. 31. Kumar V, Anand R, Messina J, et al. An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors. Eur J Neurol. 2000;7:159-169. 32. Knapp MJ, Knopman DS, Solomon PR, et al, for the Tacrine Study Group. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA. 1994;271:985-991. 192 M. Moreno 33. Lindstrom MJ, Bates DM. Newton-Rapshon algorithms for linear-mixed effects models for repeated measure data. J Am Stat Assoc. 1998;83:1014-1022. 34. Thai LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 1996;47:705-711. 35. Rogers SL, Friedhoff LT, for the Donepezil Study Group. The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial. Dementia. 1996;7:293-303. 36. Rogers SL, Doody RS, Mohs RC, Friedhoff LT, for the Donepezil Study Group. Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study. Arch Intern Med. 1998; 158:1021-1031. 37. Corey-Bloom J, Anand R, Veach J, for the ENA 713 B352 Study Group. A randomized trial evaluating the efficacy and the safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol. 1998;1:55-65. 38. Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial. BMJ. 1999;318: 633-638. 39. Amenta E Bronzetti E, Del Valle M, Vega JA. Effects of alpha-glycerylphosphorylcholine in neuroanatomy of aging brain in experimental animals [in Italian]. Basi Raz Te~: 1990;20:31-38. Address correspondence to: Scientific Department, Italfarmaco SpA, via dei Lavoratori 54, 20092 Cinisello Balsamo, Milan, Italy.

    (https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=98)



  • VitaNet ® LLC. Discount Vitamin Store.