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Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?   
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592) Is it okay to pair your morning coffee and workout routine? 
Date:
December 14, 2016 02:59 PM
The views on caffeine are mostly negative. However, a recent study is giving the chemical a little positive light. Research published in the British Journal of Sports Science showed that people who drank some coffee before performing their exercise routine were happier and completed their tasks 4.2 seconds faster, on average. It is important to keep in mind that black coffee is preferred and you should always drink plenty of water during your routine also. This Minimizes the amount of sugar you ingest and keeps you from getting dehydrated. Key Takeaways:
"Research has shown that downing a cup of coffee before you break a sweat can boost your performance significantly." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3643) Can Rhodhiola Help Improve Mood?
Date:
April 10, 2014 12:15 AM
Health benefits of rhodiola
Today, rhodiola is one of the top recommended herbal cures to improve mood level. As per research, fatigue is found to be as a common health issue in today's busy life. Uncontrolled fatigue may negatively influence the daily life activities of person. This condition can be minimized by including rhodiola in daily diet. It stimulates blood circulation in body and Minimizes the risk of health issues. Low immunity health is a main cause of many health problems. How to boost our immunity health naturally? This is a common question heard from people. Today, there are many herbal products available online to improve our immunity health. Rhodiola extract is one of the best-used herbs to improve the immunity health of body. Boosting up the functioning of brain cell is a highlighting function of rhodiola extract. It stimulates the blood flow in brain and enhances your memory capacity. Reducing body weight is another main advantage of using rhodiola extract. Uncontrolled obesity can lead way to several health issues in life like heart failure and stroke. This condition can be minimized by including rhodiola extract in daily diet. Today, rhodiola is one among the key ingredients used for the preparation of products that can enhance your energy level and mood level. If you are in search of a safe herbal remedy to improve mood level, then never hesitate to include rhodiola extract in daily diet.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3088) Castor oil
Date:
December 29, 2013 05:08 PM
What is Castor Oil
Benefits of castor oil Castor oil have been found to help in many day to day problems, they include: Yeast infection constipation: Castor oil has strong laxative thus very effective when it comes to constipation, you can mix with some juice to take away the bitterness. Arthritis Natural remedy: Castor oil contains anti- inflammatory properties making it an excellent massage for reliving arthritic joints, nerve inflammation and sole muscles. Acne: The medicinal content in castor oil makes the skin healthy and Minimizes a menstrual disorder castor oil consist of ricinolec acid which is anti-inflammatory, oral consumption of 2 spoonful will reduce menstrual pains and other body pains. Hair growth: Fatty acids and vitamin E aids in hair growth. Anti allergic: Castor oil is anti allergic in nature thus helps in allergies related to skin ans naso-pharyngeal. Increases immunity: Castor oil increases white blood cells thus fights infections. Labor induction: When castor oil is given to pregnant female who are at full time pregnancy it induces labor by pushing of uterus contraction giving easy child birth. Chemotherapy drugs: Castor oil acts as medium chemotherapy drug to some cancerous tumors. Castor oil is used to reduce warts, moles and cysts, apply castor oil with a pinch of banking soda and wait for the desired results. Ringworm's known to be the most stubborn fungal infection castor oil has a compound known as undercylenic acid which is known to be effective in treating the fungal infections. Castor oil thickens eye brows and eye lashes, since castor oil enhances hair growth just apply castor oil in your eye brows and lids everyday. References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2941) How D-ribose boost energy levels in the body
Date:
October 27, 2013 09:40 PM
D-ribose is a simple sugar, prontose sugar, or 5-carbon monosaccharide. It is used by all body cells and is essential component in energy metabolism. Ribose also gives the structural backbone of body genetic materials like RNA and DNA, certain vitamins and other vital cellular compounds. It provides raw material to facilitate the production of adenosine triphosphate.
D-ribose was discovered in late 1990s by an American company. People who were suffering from fatigue and chronic related illnesses could be given pure adenosine triphosphate instead of AMP. This new supplement was produced in a stable and safe natural form that allowed it to be sold as nutritional supplement.
Ribose is an essential ingredient in stimulating the production of natural energy. It promotes the cardiovascular health, Minimizes cardiac stress associated with strenuous events. Ribose enables the muscles and heat to maintain healthy energy level as well as accelerating the recovery of energy when body tissues are stressed by overwork, strenuous exercise, or disease. The physiological fuction of d-ribose is known as 5-phosphoribosyl-1-pyrophosphate, which controls the metabolic path that synthesizes energy components in all body living tissues. In case the cellular energy pool is depleted by overwork, diseases or exercise it must be replaced. 5-phosphoribosyl-1-pyrophosphate will stimulate the metabolic pathway to replenish these energy pools.
Patients with myocardial ischemia condition or reduced blood flow resulting from reduced oxygen flow to the heart may experience discomfort and chest pain. This may cause heart attack to a person with such experience. The ability of the heart cells to expand and contract depend upon the adenosine triphosphate available. The reduced blood flow lowers the level of adenosine triphosphate, but this can as well be replenished by 5-phosphoribosyl-1-pyrophosphate. D-ribose stimulates the 5-phosphoribosyl-1-pyrophosphate production, which in turn increases the level of adenosine triphosphate. This will actually restores the heart cell contractile functions and reduces ischemia.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2861) Various Health Benefits of Acai Berry-The Wonder Fruit
Date:
February 12, 2012 07:32 PM
Acai berry is a highly nutritious fruit that grows in Amazon valley situated in the rain forests of the Northern Brazil. Being very small in size, it grows on palm trees that are known as Euterpe Oleracea. Acai berry is rich in fatty acids, amino acids, fibers, anti-oxidants, minerals and various vitamins. The fruit itself is very delicious tastes like chocolate candy. As acai berry is so rich in antioxidants, it provides sufficient nutrition for fighting off all the harmful effects of free radicals, decreases high cholesterol levels, lowers high blood pressure and helps in reliving the joint pain. Aside from being a great source of energy, it helps body in fighting off infections by strengthening the immune system. Today acai berry is regarded as a top super food. Acai berry also contains large amounts of trace minerals, and phytonutrients. Its ORAC score (a measure of antioxidant levels) is much higher than any other vegetable or fruits tested on gram for gram basis. Its high fiber and protein content helps in boosting the body's immune system. Various Health Benefits of Acai berry 1. Weight Loss-Acai berry helps in increasing the body metabolism rate within few days thereby helping you in shedding those extra pounds. 2. Regular intake of Acai berry fruit helps all those who suffer due to lack of sleep. Its amazing nutrients help in inducing sleep in the people. 3. Acai berry helps in removing harmful toxins from the body. 4. It Minimizes the inflammation of stomach and liver to a great extent and assists in oxidation. 5. It helps all those who are suffering from depression and strengthens the cardiovascular system. It also regulates the nervous system in the body leading to better functioning by various body organs. 6. It provides relief to all those who are suffering from acute arthritis pain. 7. Speeds up recovery process in case of injuries. 8. Controls diabetes and stabilizes blood sugar level. 9. Sharpens eyesight and improves the functioning of digestive system. 10. Antiviral properties- Acai berry is rich in Anthocyanins (compounds found in red wine) which have good antiviral properties and boost your immune system which help you in fighting off diseases and illnesses. 11. Antiallergenic properties- Due to the presence of Antocyanins, the Acai berry has excellent antiallergenic properties. 12. Good fiber content- Fiber contents helps in cleansing your body by flushing out toxins. It also make you feel full with less food. Acai berries have 4 grams of fiber for every 100 grams of serving. 13. Lowers bad cholesterol-Acai berries are rich in Omega-9 and Omega-6 fatty acids that lowers LDL cholesterol which hardens arteries leading to heart disease. Best Colon Cleansing Agent Acai berry is a good colon-cleansing agent and also helps in detoxifying the body in a natural way. It acts swiftly on the midriff region, and enhances the weight loss in your tummy area. You can get Acai berry in various forms such as pills, snack bars, powder and fruit juices. Many world class companies offer their Acai berry products to world wide customers. You can even get freeze dried Acai berries as they have the highest concentration of nutrients in them.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2572) Supplements good for reducing stress and boosting energy!
Date:
March 26, 2007 02:05 PM
Vitality 101
More and more Americans are feeling overworked, overtired, and overcome by life’s demands. We just do not have the energy we need to meet our responsibilities to the people we care about. More importantly, we don’t even have the energy to have fun! It seems that a constant feeling of fatigue has become part of the American way of life.
Research has shown that the same processes that cause lack of energy can rob us of sleep, saddle us with excess weight, disrupt our hormonal balance, and create significant amounts of stress in our daily lives. Chronic stress can dramatically contribute to fatigue, sleep disorders, irritability, and anxiety. The research simply confirms what most of us already know – uncomfortable stress can really wear us out mentally and physically! It can take away the satisfaction of a job well done. It can take away our ability to believe in ourselves. And, sadly and maybe most importantly, continual stress can take the fun and joy out of life.
In a separate issue of Ask the Doctor, we discuss the energy and sleeping needs of people suffering from chronic fatigue syndrome and fibromyalgia. In this issue, I discuss the 3-step process I call “Vitality 101.” People do not have to accept pain, insomnia, or fatigue. It’s time for everyone to feel great and have a life they love!
Step 1 – Nutrition
Good overall nutrition is important for everyone! As a foundation product to support energy levels, a powdered drink mix is a pleasant, easy way to ensure that you are taking all of the necessary vitamins, minerals, and amino acids that you need to have great energy all through your day.
The following chart lists the most critical ingredients. You can see that almost all of the vitamins and minerals work together to help improve energy levels and overall health.
In addition to the powdered energy drink mix, it is important that you also take a high potency vitamin B-complex supplement. This should include niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, which are especially important to restore the energy production needs of your body. It is also critical to get enough water, as most Americans are chronically dehydrated.
Step 2 – Rest Your Body
Having trouble sleeping is one of the most troubling symptoms of stress. While the stress is wearing us down and making us tired, it’s also keeping us tense and unable tot relax. The result? That easy drift into sleep becomes harder and harder. And if we are lucky enough to actually get some shut-eye, stress will often wake us up, sometimes several times a night.
This occurs because excess stress suppresses the sleep center in the brain. It is important to break the “stress/insomnia cycle” early, before it results in pain and hormonal and immune dysfunction!
Because good quality sleep is how the body repairs and re-energizes itself, it may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Look for a supplement that has a blend of herbs that promote deep sleep, such as valerian, L-theanine, hops, passionflower,
Step 3 – Manage Excess Stress Levels
In this fast paced world, it is important to learn to manage the stressor in our lives. Glandular extracts, such as raw adrenal extract, can offer natural support to help our bodies deal with the effects of stress and, in turn, can boost your energy levels. Exercise is another stress buster. Using your body physically is important for good health. Find something that is fun for you, however, or you are unlikely to stick with it!
Q. Does stress zap my energy in any other ways besides making me lay awake at night and causing me to be a zombie the next morning?
A. Most people are familiar with the body’s dramatic response to an emergency. The heart pounds, the muscles constrict, and the lungs expand – and while this is happening, we are capable of greater than normal strength and speed. This response is the body’s way of rescuing itself when faced with an emergency. We don’t have to think about it to make it happen. It’s automatic.
The same can be said of a chronic stress response. Whether we’re late for a business meeting because we’re stuck in traffic, or worrying about how we are going to pay for our children’s college tuition, our response to stress happens automatically. The difference between the two is that the body’s response in an emergency starts and resolves itself quickly. The response to being stuck in traffic may not.
The body makes the “stress hormone”, cortisol, to handle the normal stresses of day-to-day living. But in an emergency situation, the adrenal glands, located above the kidneys, secrete increased amounts of this hormone until the emergency passes. Then the body returns to its normal function. Unfortunately, however, chronic stress is more complex. When our body is subjected to increased amounts of the hormone, cortisol, for an extended time, it can lead to a condition known as “adrenal burnout” or “adrenal fatigue.” While it’s true that very large amounts of cortisol can have damaging effects on our hormones, too little cortisol doesn’t allow us to respond to stress properly. It’s really a matter of balance.
Q. How can I control the stress in my life and re-energize?
A. Many people who are under constant stress may have adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress.
The good news is that changes in our hormone levels can return to normal when stress is decreased. The key in learning how to deal with daily stress is to allow the body to return to its normal state. I discuss additional techniques for coping with stress in my recent book Three Steps to Happiness! Healing Through Joy (see my website, www. jacobeitelbaum .com, for more information). In addition to stress control, it is important to supplement your adrenals with a glandular therapy regimen to ensure healthy cortisol levels and adrenal function. Glandular therapy, which uses the concentrated forms of bovine (cow) or porcine (pig) glands, can improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacked and thus repaired the malfunctioning gland.
Adrenal Extract
If you are one of the unlucky folks with stressed-out adrenal glands, you should see great results from taking raw adrenal supplements. Be sure to buy adrenal extract supplement that contains both whole adrenal and cortex adrenal.
The best adrenal supplement should also contain vitamin C, vitamin B6, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients.
Liver Extract
Did your grandmother ever tell you to eat your liver so that you didn’t get “tired blood?” Well, it turns out that she was right. Liver extract is another glandular extract that can help improve energy levels.
Liver extract is an excellent source of highly bioavailable nutrients including iron, B vitamins (especially B12), and other minerals. The stamina and energy-enhancing benefits of liver are widely touted. Liver extract has been shown to support healthy function of the liver and increase the energy levels inside our body.
Because heat will destroy the key components in the liver, a high quality liver extract supplement should be cold-processed and encapsulated to enhance speed and absorption of nutrients from liver. A high quality aqueous liver extract supplement should also contain vitamin B12 to support healthy blood iron and oxygen levels to energize.
Q. It will be great to get a good night’s sleep. Are there also any other natural alternatives that could help promote relaxation and increase my energy levels during the day?
A. Yes, there are. Rhodiola rosea is an all-natural herb that has long been used to help relieve stress and increase energy. Rhodiola has also been used to lift our moods, improve sexual satisfaction, and even help in certain nervous system disorders. First used in Siberia and
In clinical trials, the most effective Rhodiola rosea extract was found to contain 3% rosavins and 1% salidroside. While there are many Rhodiola supplements in health food stores, only those containing these specific amounts can provide the best results.
Lifestyle Treatments
Altered digestion, food intolerances, decreased energy, fatigue, cognitive problems, and sleeplessness create the need for changes in daily living routines. These can include alterations in diet; exercise modifications; alterations in activities of daily living according to one’s energy level; and sleep/rest management. All may require the assistance of a professional clinician, such as a chiropractor, nutrition specialist, physical and/or occupational therapist, mental health professional, or sleep therapist.
Conclusion
Super busy lives demand super strength nutrition. Begin each day with a powdered nutritional supplement after getting at least 8 hours of sleep each night. In addition to the nutritional beverage mix, a vitamin B complex supplement should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients to combat your fatigue. Taking a daily adrenal supplement, like the one discussed earlier, will provide the much needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy. Rhodiola rosea, and ginseng can offer additional natural nutritional support in your busy life to boost your energy levels. These nutritional supplements can be used daily and you will feel energized to get through each day’s challenges and opportunities!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1496) Energy Vitamins
Date:
June 11, 2005 05:50 PM
Energy Vitamins by Daniel Mowrey, PhD Energy Times, June 7, 1998 Do you suffer groggy mornings clouded with tired and achy feelings? Do you have to struggle to muster sufficient energy to cope with the day? Then, throughout the morning and afternoon, does frequent fatigue, weakness or depression persist on your horizon like an ugly storm cloud? And your evening may bring little relief as you slump into bed for a restless night, only to begin the same routine the next morning. If lack of vim and vigor plagues your days and nights, your body may be suffering from an inability to synthesize sufficient energy. Our lives depend on processing the food we eat into substances our cells can take in and use. In a never-ending cycle, our body breaks food down and reconstructs the components to form body structures and burn as energy. How much you exercise, the food and supplements you eat and how much you sleep influence the efficiency of these processes. Vitamins and Energy Certain nutrients are called vitamins because they are crucial for vitality. These nutrients are essential to a productive life, the starting point for all life-giving and life-sustaining processes. Because of vitamins' crucial role in energy production, many people can perk up their stamina simply by consuming an adequate supply of vitamins in their daily diet. Since many vitamins - especially the ones concerned with energy - must be constantly replenished, a decent diet and the right supplements must be consumed every day. Be Energetic with B Vitamins Vitamins, especially the B vitamins, play extremely important roles in producing cellular energy. Their most important roles are shown in the illustration on page 48. The chart on page 46 lists the key vitamins and describes their effects as well as the consequences of not getting enough of them. Their effect is felt most profoundly in the energy producing process known as the Krebs cycle (which we'll explain in a moment). Vitamins B2 and B3, for example, supply the major building blocks for substances called flavin adenine dinucleotide (FAD and FADH) and nicotinamide adenine dinucleotide (NAD and NADH) which are critical elements of producing energy in the Krebs cycle as well as a process called oxidative phosphorylation. Even though you may never have heard of NAD and NADH, these molecules are found in many places in your body; they play a role in hundreds of biochemical reactions in all kinds of cells. B vitamins also combine with other materials to build coenzymes, chemicals which help form other chemicals necessary for cellular energy. B vitamins are crucial: miss out on one or more and you may break these metabolic chains necessary for peak energy. Energy to Spend The main energy currency of every cell is ATP: adenosine triphosphate. This material is used by cells for every imaginable task including reproduction, growth, movement and metabolism. Specialized metabolic cycles within the cell are designed to generate ATP. Consequently, the more ATP our cells create, the more energy can be generated. The raw materials used to make cellular energy are glucose (blood sugar) and "free" fatty acids. The best way to supply your cells with the sugar they need is to consume complex carbohydrates which also supply fiber and other nutrients. When you eat carbohydrates, they are made into glucose which is stored as a starch called glycogen in muscles and the liver. Your body can rapidly turn glycogen into glucose for extra energy (The process of making energy from glycogen yields carbon dioxide and water as well as ATP.) Making Energy The first step in making glucose into energy is called glycolysis. This complicated process requires nine different steps. During these steps, glucose is made into a substance called pyruvate. The process of glycolysis requires ATP, but yields twice as much ATP as is present when it starts. From here, the process gets a little more complicated as pyruvate enters into a complex chain of events in tiny cellular structures called mitochondria. (Many metabolic events take place in the mitochondria.) The pyruvate molecules are converted to a molecule known as acetyl coenzyme A and eventually made into carbon dioxide, water and more ATP. This process is known as the Krebs cycle or citric acid cycle. It also involves a series of events known as oxidative phosphorylation in which NADH formed during the Krebs cycle is oxidized to form ATP. Why is fat such a concentrated source of energy? Free fatty acids enter the Krebs cycle to help generate ATP much more efficiently than glucose - producing roughly six times more energy per gram than glucose. Get Your Vitamins Every Day While we rely on our diet to supply many of our vitamins, a B complex supplement and multi-vitamins can ensure you consume sufficient amounts of these crucial nutrients. Many experts agree that a diet rich in raw fruits, nuts and vegetables that Minimizes saturated fat can supply adequate a-mounts of these nutrients. Other supplements that may aid energy production: Alpha Lipoic Acid, an antioxidant that works in the fatty tissues of cell membranes and in cells' watery interiors. CoQ10, a nutrient that protects cell membranes, especially of the heart, against oxidation and toxins. Plus, herbs such as suma, ginseng and licorice root as well as creatine, carnitine and pyruvate. Of course if you suffer from any long term, intractable fatigue, consult your health practitioner. But for most cases of decreased vim and vigor, adequate vitamins should help your body recover your get up and go.
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Date:
June 09, 2005 05:36 PM
Energy Vitamins by Daniel Mowrey, PhD Energy Times, June 7, 1998 Do you suffer groggy mornings clouded with tired and achy feelings? Do you have to struggle to muster sufficient energy to cope with the day? Then, throughout the morning and afternoon, does frequent fatigue, weakness or depression persist on your horizon like an ugly storm cloud? And your evening may bring little relief as you slump into bed for a restless night, only to begin the same routine the next morning. If lack of vim and vigor plagues your days and nights, your body may be suffering from an inability to synthesize sufficient energy. Our lives depend on processing the food we eat into substances our cells can take in and use. In a never-ending cycle, our body breaks food down and reconstructs the components to form body structures and burn as energy. How much you exercise, the food and supplements you eat and how much you sleep influence the efficiency of these processes.
Vitamins and Energy
Be Energetic with B Vitamins Vitamins B2 and B3, for example, supply the major building blocks for substances called flavin adenine dinucleotide (FAD and FADH) and nicotinamide adenine dinucleotide (NAD and NADH) which are critical elements of producing energy in the Krebs cycle as well as a process called oxidative phosphorylation. Even though you may never have heard of NAD and NADH, these molecules are found in many places in your body; they play a role in hundreds of biochemical reactions in all kinds of cells. B vitamins also combine with other materials to build coenzymes, chemicals which help form other chemicals necessary for cellular energy. B vitamins are crucial: miss out on one or more and you may break these metabolic chains necessary for peak energy.
Energy to Spend Consequently, the more ATP our cells create, the more energy can be generated. The raw materials used to make cellular energy are glucose (blood sugar) and "free" fatty acids. The best way to supply your cells with the sugar they need is to consume complex carbohydrates which also supply fiber and other nutrients. When you eat carbohydrates, they are made into glucose which is stored as a starch called glycogen in muscles and the liver. Your body can rapidly turn glycogen into glucose for extra energy (The process of making energy from glycogen yields carbon dioxide and water as well as ATP.)
Making Energy From here, the process gets a little more complicated as pyruvate enters into a complex chain of events in tiny cellular structures called mitochondria. (Many metabolic events take place in the mitochondria.) The pyruvate molecules are converted to a molecule known as acetyl coenzyme A and eventually made into carbon dioxide, water and more ATP. This process is known as the Krebs cycle or citric acid cycle. It also involves a series of events known as oxidative phosphorylation in which NADH formed during the Krebs cycle is oxidized to form ATP. Why is fat such a concentrated source of energy? Free fatty acids enter the Krebs cycle to help generate ATP much more efficiently than glucose - producing roughly six times more energy per gram than glucose. Get Your Vitamins Every Day While we rely on our diet to supply many of our vitamins, a B complex supplement and multi-vitamins can ensure you consume sufficient amounts of these crucial nutrients. Many experts agree that a diet rich in raw fruits, nuts and vegetables that Minimizes saturated fat can supply adequate a-mounts of these nutrients. Other supplements that may aid energy production: Alpha Lipoic Acid, an antioxidant that works in the fatty tissues of cell membranes and in cells' watery interiors. CoQ10, a nutrient that protects cell membranes, especially of the heart, against oxidation and toxins. Plus, herbs such as suma, ginseng and licorice root as well as creatine, carnitine and pyruvate. Of course if you suffer from any long term, intractable fatigue, consult your health practitioner. But for most cases of decreased vim and vigor, adequate vitamins should help your body recover your get up and go.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=260) The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
Date:
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005. “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.” Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.” Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. . Abstracts PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892 Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders. INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events. INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) Minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
Bibliographies David Heber, MD, PhD, FACP, FACN Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center Matthew Budoff, MD, FACC Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=257) Bioflavonoid Complex - Botanical Antioxidant Protection 
Date:
June 01, 2005 09:15 AM
Specialty Bioflavonoids Bioflavonoids occur as pigments in plants, where they are found in close association with vitamin C. Together, bioflavonoids and C provide antioxidant protection, helping plants withstand harsh environmental conditions. BIOFLAVONOID COMPLEX features potent botanical extracts, many of them standardized to specific beneficial constituents. Included are bilberry, ginkgo biloba, grape seed, green tea, hawthorn berry, quercetin, and silymarin. The formula is enhanced by the addition of vitamin C as highly bioavailable magnesium ascorbate.
References
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Rhodiola, renowned for amazing health benefits is a safe herb that can increase the energy level of body. It is one of the best-used herbs for the treatment in wide range of health issues like fatigue. Stress, a main cause of many nervous disorders can be easily cured with the help of rhodiola. It relaxes nerve cells and improves blood flow in body. This function of rhodiola can prevent a wide range of health issues like depression, stress and anxiety. 
Castor oil is an inflammatory and anti oxidant oil. A very pale yellow liquid extracted from castrol seed, with high concentration of unsaturated fatty acid,although with unpleasantand strong taste castor oil is used as medicine.
