Search Term: " Myristoleate "
Cetyl Myristoleate to Encourage Healthy Cells
October 29, 2013 10:01 PM
Which is a plant and animal oil derived natural fatty acid, has been found to have a good effect on joint inflammation. To be very accurate, the natural compound can be very effective for controlling complications of arthritis. However, researchers are still trying to examine the compound in order to unfold many other beneficial aspects.
Source of Cetyl Myristoleate
This compound can be found in both vegetable and animal sources. People who only prefer to have vegetarian sources can get this compound from nuts. If a person does not mind to have the compound from an animal source, he/she can get it from the oil of the sperm whale and beef tallow.
Cetyl Myristoleate Benefits
· Among many other benefits, the effect of this compound on the joint problem has got maximum exposure.
· This fatty acid is equally effective for managing autoimmune diseases like lupus, psoriasis, fibromyalgia and gout. When the immune cells start to attack other healthy cells of the body, it causes autoimmune diseases.
· Cetyl Myristoleate also gives power to the healthy cells that altogether build an immune system strong enough to fight the foreign invaders.
Arthritis is a common problem in adults. Cetyl Myristoleate can make a huge difference in the condition by lubricating the joints suffering from inflammation. It is an excellent mean to encourage the healthy cells of the body. By having a prescribed dosage of this nutrient, one can improve the skin texture, the condition of heart, arteries and nerve.
Cetyl Myristoleate is an excellent mean to safeguard against the autoimmune diseases. People can make a great use of this fatty acid to get a relief from the acute joint inflammation problem and reduce the pain. As the effect of this element is still under observation, to be able to use the element extensively, people might have to wait a bit longer.
May 08, 2008 03:47 PM
Cetyl Myristoleate is a fatty acid ester used largely as a dietary supplement to support joint mobility and the immune system. Chemically it is a natural hexadecyl ester of cis-9-tetradecanoic acid, an unsaturated fatty acid commonly known as myristoleic acid.
The acid is found naturally in fish and whale oils, and also in butter and kombo butter from the kombo nut. The ester is of a buttery consistency at normal room temperatures, and turns waxy when cooled, and it has no known uses other than as a health supplement, particularly for the treatment of arthritis and other inflammatory and immune system problems.
The substances appear to have similar therapeutic characteristics to unsaturated essential fatty acids, but with a stronger and more long lasting effect. It also appears to work in three distinctly different ways in that it acts as a joint lubricant, supports the immune system and functions in the same way as essential fatty acids.
Arthritis is a disease that has reached epidemic proportions worldwide, and it is estimated that more than 50 million Americans are affected by it. Until recently it was believed to be a disease of the aged, or associated with physical injury, but is now known to be more complex than that, with many manifestations and causes. Because of this, no single treatment is effective with all forms of arthritis, but cetyl Myristoleate is the new kid on the block that is believe to make a significant contribution to the treatment of non-infective forms of the disease.
However, it was not always known, and a search in the textbooks for cetyl Myristoleate prior to 1977 would have yielded nothing. Why 1977? It started with Harry W Diehl, a sugar chemist with an interest in the treatment of arthritis. While carrying out research on arthritis in mice, he was working on thin layer chromatographic analysis of a methylene chloride extract of macerated mice. He noticed a separation that was unknown to him, which was subsequently identified as cetyl Myristoleate.
He had been unable to induce arthritis in mice, and believed that if he found out how to do that, then he should also be able to establish what made the mice immune to the disease, and so establish a cure. He soon established that it was this cetyl Myristoleate circulating in the blood that protected the mice, and then found a way of synthesizing it in the lab by esterifying myristoleic acid.
Since the compound was unknown at that time Diehl patented it in 1977, hence the date. Apart from in mice, it has subsequently been found only in whale oil and in one of the glands of the male beaver, with no other known sources at the time of writing. There have been several studies that have supported the effect of cetyl Myristoleate on arthritis, the first human study being in 1995 when 46 out of 48 arthritis patients showed significant improvement in articular mobility and reduction in pain. Others since have demonstrated similar results.
So how does it work? What is the mechanism by which this hitherto unknown substance helps to relieve the symptoms of osteo and rheumatoid arthritis? Being a fatty acid ester, cetyl Myristoleate possesses lubricant properties, and one of its properties is to supplement the synovial fluid that lubricates the joints and tendons. This helps to keep the joints moving freely, and reduces their tendency to grind when the connective tissue wears. It also lubricates entire muscle groups, allowing them to slide over each other more freely, and also over bones allowing a smoother movement of the joints.
The second way, in which it operates, by supporting the immune system, is particularly appropriate to the treatment of rheumatoid arthritis which is caused by the immune system attacking the body’s own joint and connective tissue. In this respect, cetyl Myristoleate has also been found effective in treating other immune system conditions such as multiple sclerosis and lupus erythematosus.
Finally, it also possesses the mediation effect on the inflammatory reaction possessed by other essential fatty acids. This helps to reduce the effect of inflammation that causes much of the swelling and pain of arthritic conditions, although it occurs much faster than with other fatty acids. When taken together, all of these effects have a powerful effect in reducing the unpleasant symptoms of both osteoarthritis and rheumatoid arthritis. Swelling is reduced, mobility is improved and pain is alleviated. Improvements have been reported by sufferers of both types of arthritis, and in fact it is reported that Harry Diehl successfully treated his own arthritis with the substance before any other human tests had been carried out.
Cetyl Myristoleate is now used word-wide in significant quantities, and there have as yet been no confirmed reports of adverse side effects. However, as with many otherwise safe supplements, it is recommended not to be taken by pregnant or lactating women until it has been proved to definitely have no side effects on the fetus or young babies.
Although there is no definitive scientific evidence of the effectiveness of the substance in relieving the symptoms of arthritis, there is an overwhelming body of evidence from those that have used it world wide. The accepted treatment is by non-steroidal anti-inflammatory drugs (NSAIDs), and with over 16,0000 NSAID-related deaths in the USA alone each year, cetyl Myristoleate is certainly worth considering as an alternative for arthritis sufferers. Not only that but there is a very significant price differential, with NSAIDs costing 5 – 10 times that of cetyl Myristoleate.
Among the other benefits that people using the substance have reported are beneficial effects on psoriasis, hepatitis, high blood pressure, eczema, allergies, headaches and many more. Although many of these might be coincidence or psychosomatic, it cannot just be coincidence that many of them, such as psoriasis and allergies, are related to the immune system.
However, anybody with asthma or a history of severe allergic reactions should consult their physician before using the substance. That aside, there is more than enough popular evidence to indicate that cetyl Myristoleate is effective in the treatment of arthritis in all its forms, and also good for your general state of health and wellness.
The Skinny on Fats - Omega-3, Omega-6, Omega-7, Omega-9
October 04, 2006 04:53 PM
Health experts keep changing the storey on fats. First we were told that polyunsaturated fats were better than saturated fats. Then it was discovered that refined polyunsaturates were favorite targets for free radical attack. Next, monounsaturated fats took center stage and have remained in the spotlight ever since. The Mediterranean Diet, with its high intake of olive and other oils high in monounsaturates, offers several important safeguards against cardiovascular disease, cancer and overall mortality. (Laino, de Largeril, Kokkinos, Trichopoulou). While monounsaturated fats are important for maintaining optimum health and smooth supple skin, it’s the kind of fatty acids and antioxidants they contain that make up the real story.
Dark green unrefined “extra Virgin” olive oil has a delightful full bodied flavor due to its natural antioxidants. Not only are the oils of various olive cultivars distinctive, they all help fight arterial plaque buildup. (Visioli) Olive oil has a long history in Europe as both food and medicine, and carbon dating of seeds found in spain have shown that the use of olive oil dates back 8,000 years. Gourmet chefs usually prefer particular oils for various uses in making dressing, marinades, and sauces for dipping. Olive orchards have now achieved a status second only to that of vineyards.
Macadamia nut oil is another designer oil that is fast gaining a reputation among chefs and health experts. The nuts originated in Australia where they were staples in the diets of the Aborigines. In 1881, they were introduced in Hawaii and in the 20th century, made their way to California where several cultivars are now grown. Like olive oil, macadamia nut oil is rich in antioxidants and contains the highest levels, greater than 80 percent monounsaturates, primarily polmitoleic (omega-7) than other oils. (Hiraoka-Yamamoto)
Macadamia nut oil products found in mass market are typically refined, with many of the antioxidants removed. The highest levels of antioxidants in macadamia nuts are found in the shells. During cold processing, some of these antioxidants leech into the oil, increasing its antioxidant potential. (Quinn) unrefined and organic oils have a golden color, pleasing nutty aroma and buttery flavor. Scientists have found that macadamia nut oil lowers, LDL cholesterol and triglycerides, and may help prevent stroke. (Yamori, Colquhoun) It is delightful on vegetables, in soups, on popcorn, and as a replacement for butter in baking.
The essential oils (Fish oils, flaxseed, GLA, DHA), which are available as liquid and packaged in black bottles, must be stored in the Refrigerator even when they have not been opened. You cannot heat or cook with them. Essential fatty acid supplements are convenient to take and have specific therapeutic value.
Cardiovascular and Nerves – Consumers have been advised to eat more fish rich in Omega-3 to reduce their risk of cardiobascular disease. However, experts worry that eating several servings of fish each week may not be safe especially during pregnancy, dursing or trying to conceive. Instead they recommend fish oil supplements such as Omega-3 from Algae , Fish oil, and Omega-6 Evening Primrose and Borage oils.
Pain Relief – A blend of cetylated fatty acids including myristate, Myristoleate, laurate, oleate, palmitate and palmitoleate appear to be effective in reducing inflammation and pain in arthritis and other inflammatory conditions. (Vanderhaeghe) In a San Diego California study of sixty-four patients with osteoarthritis, an oral preparation of cetylated fatty acids known as celadrin significantly improved range of motion and flexibility. (Hesslink)
Two other studies of osteoarthritis patients at the University of Connecticut, using a topical preparation of Celadrin, showed significantly greater knee stability, improvement in stair climbing ability, balance and strength, and reduction of pain. (Kraemer)
Animal studies at the University of Minnesota have shown that cetylated fatty acids administered either topically or orally are well tolerated and rapidly dispersed throughout the body. (Gallaher) Doses for the oral form are 1500mg three times a day. The topical cream is applied two to four times a day.
December 22, 2005 09:37 AM
Glucosamine & Chondroitin - JOINT HEALTH
Everyone old enough to walk appreciates the value of fl exibility and ease of movement. Unfortunately many of us take such good things for granted. A famous folksinger sang, “You don’t know what you’ve got till it’s gone.” That’s certainly true for millions of Americans who live with stiff and uncomfortable joints.
Fortunately there are a number of nutrients available that provide the vital components of healthy joint structure and function and ease of mobility. These nutrients are referred to as “chondroprotective agents,” and include glucosamine and chondroitin, which supply the raw material necessary to produce new cartilage, and may even help rebuild worn cartilage. Other chondroprotective nutrients and herbs, like Cetyl Myristoleate, MSM, and Boswellin, work synergistically with glucosamine and chondroitin and further support normal joint function To understand how chondroprotective agents work, one must fi rst understand how joints work. The key element in human joints is articular cartilage, the shock-absorbing tissue that connects two bones together and allows pain-free movement. Articular cartilage is comprised of two different molecules, collagen and proteoglycans, with the remainder composed primarily of water (65-85%). Collagen, a protein that binds tissue together, provides elasticity. Proteoglycans, composed of sugars and protein, absorb water, which provides lubrication and resiliency, nature’s shock absorber for your joints. Both compounds are produced by chondrocytes, caretaker cells responsible for the formation and maintenance of cartilage. A defi ciency in any one of the above constituents will increase the likelihood of wear and tear on articular cartilage, which can eventually lead to compromised joint function.
Glucosamine and chondroitin are safe, natural and effective nutrients that support healthy joint function by supplying the materials needed to produce collagen and proteoglycans.
Glucosamine is composed of glucose (a sugar) and glutamine (an amino acid). It is utilized by chondrocytes to form glycosaminoglycans (GSG) and proteoglycans (PG). Both of these constituents attract and bind water into cartilage, increasing resiliency. Research indicates that glucosamine may actually help your body repair damaged or eroded cartilage. A number of studies have been conducted on glucosamine sulfate and glucosamine hydrochloride, with a preponderance of positive results. Glucosamine sulfate is considered the more effective of the two. One study from the University of Liege in Liege, Belgium studied the effects of glucosamine sulfate on 212 patients with knee osteoarthritis. Participants took either 1,500 mg glucosamine or a placebo once daily for three years. The study compared joint-space width at enrollment, one year, and at the study’s conclusion.
The 106 patients on placebo had a progressive jointspace narrowing, while participants taking glucosamine experienced no significant joint-space loss, indicating glucosamine may benefi cially modify cartilage structure.3 A study published in the journal Osteoarthritis and Cartilage in 1998 investigated the in vitro effects of glucosamine sulfate on proteoglycan and collagen production by chondrocytes taken from osteoarthritic articular cartilage. The results showed “a statistically signifi cant stimulation of PG production by chondrocytes from human osteoarthritic cartilage cultured for up to 12 days in 3-dimensional cultures.” 4 Another study from Italy enrolled eighty inpatients with established OA. They received either 1,500 mg of glucosamine sulfate or placebo daily for 30 days. The patients treated with glucosamine sulfate experienced a reduction in symptoms almost twice as large and twice as fast as those receiving placebo. Researchers also used electron microscopy of patient’s articular cartilage to support this hypothesis. Patients who received glucosamine sulfate showed a picture more similar to healthy cartilage. The researchers concluded that glucosamine sulfate tends to rebuild damaged articular cartilage and restore articular function.5
Chondroitin is classifi ed as a glycosaminoglycan. It bonds with collagen to form the basis of connective tissue. Chondroitin helps attract fl uid into proteoglycans, thereby bringing nutrients into cartilage and providing shock absorption. While glucosamine helps manufacture and maintain cartilage, chondroitin keeps cartilage from becoming malnourished. Chondroitin works synergistically with glucosamine, and these two nutrients form the basis of most joint health supplements on the market today. A 6-month randomized, multi-center, double-blind, doubledummy study published in 1996 compared the effectiveness of chondroitin versus a popular non-steroidal anti-infl ammatory drug (NSAID) in patients with knee osteoarthritis (OA). One hundred and forty-six patients with knee OA were recruited and separated into two groups; an NSAID group and a chondroitin sulfate (CS) group. The NSAID group was given the NSAID and a placebo for the fi rst month, then placebo alone for months 2-3. The CS group was given the NSAID and CS for the fi rst month, and then CS alone for months 2-3. Both groups were then given 1200mg of CS for months 4-6. “Patients treated with the NSAID showed prompt and plain reduction of clinical symptoms, which, however, reappeared after the end of treatment; in the CS group, the therapeutic response appeared later in time but lasted for up to 3 months after the end of treatment. CS seems to have slow but gradually increasing clinical activity in OA; these benefi ts last for a long period after the end of treatment.”6
NOW® Foods is your source for natural joint support products. Our Extra Strength Glucosamine & Chondroitin is one of our best-selling products, and we also have combination supplements that include MSM, Concentrace® minerals, and more. We also carry both glucosamine and chondroitin as separate products, as well as in powder and lotion forms.
Celadrin and MSM Fact Sheet
December 07, 2005 01:24 PM
Celadrin and MSM Fact SheetNeil E. Levin, CCN, DANLA Certified Clinical Nutritionist, Diplomate in Advanced Nutritional Laboratory Assessment Revised 11/10/05
LIKELY USERS: People lacking flexibility or mobility; People wanting temporary control of aches and pains; People wanting to reduce pro-inflammatory body chemicals. KEY INGREDIENT(S): Celadrin® powder 500 mg. Provides 350 mg. of actual EFAC (esterified fatty acid carbons). This is a proprietary blend of Esterified Fatty Acid Carbons of Myristate, Myristoleate, Laurate, Oleate, Palmitate and Palmitoleate in a base of tapioca and silica.
MSM 100 mg.
MAIN PRODUCT FEATURES: CELADRIN® is an all-natural proprietary matrix of esterified (cetylated) fatty acid carbons (EFAC) derived from tallow of USA-raised cattle. This product is developed through a proprietary process of esterifying oil & has been clinically tested. Celadrin promotes joint health by improving flexibility, pain management and mobility. The myristoleic acids and the cetylated forms may alter the 5-LOX enzyme and change the leukotriene production, inhibiting inflammatory compounds.
Celadrin® may offer some noticeable benefits faster than other substances, like glucosamine and chondroitin. Though it is not a substitute for these important tissue-building nutrients. ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: MSM has synergistic abilities to reduce certain substances in the body which may affect the inflammatory process.
Contains Cetyl Myristoleate (CM, CMO), but in a patented blend of other fatty acid carbons. This product (Celadrin ®) has its own clinical studies showing safety and efficacy.
Also will be available in a softgel of the same potency (350 mg. of EFAC) as of December 2005 (product 3017, 90 softgels)
SERVING SIZE & HOW TO TAKE IT: Three capsules a day, preferably with meals.
POSSIBLE SYNERGISTS: Glucosamine, Chondroitin, MSM, Joint Support Products, Manganese, Vitamin C, other Antioxidants
GENERAL: Pregnant and lactating women, and people using prescription drugs, should consult their physician before taking any dietary supplement.
This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients.
When taking any new dietary supplement, use common sense and cautiously increase to the full-recommended dose over time, looking for possible side effects. Repeat this process for each new supplement that you start to use.
REFERENCES: 1. J Rheumatol. 2002 Aug;29(8):1708-12. Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis. Hesslink R Jr, Armstrong D 3rd, Nagendran MV, Sreevatsan S, Barathur R.
Joint Response and Ultra Joint Response
June 02, 2005 01:01 PM
Many people are unaware of the multiple body systems involved with joint health. Source Naturals ULTRA JOINT RESPONSE™ is a Bio-Aligned Formula™ that goes deep to bring alignment to these multiple systems. It features structural building blocks, tissue production cofactors, and ingredients that aid the body’s mechanisms for soothing relief and antioxidant defense.
Joint Support Formulations
You can use ULTRA JOINT RESPONSE alone or as the core of your healthy joints program, complementing it with additional potencies and ingredients. These include: GLUCOSAMINE CHONDROITIN WITH MSM™, MSM Cream, SAME, CM COMPLEX™ Cetyl Myristoleate, and BROMELAIN. For muscle discomfort and fatigue, Source Naturals also offers you FIBRO-RESPONSE™ Bio-Aligned Formula.
ULTRA JOINT RESPONSE™: BIO-ALIGNED FORMULA
ULTRA JOINT RESPONSE uses scientifically researched ingredients and nutritive co-factors for a comprehensive approach to soothing, lubricating, rebuilding and aligning connective tissue, joints, tendons and ligaments. MSM dietary sulfur, glucosamine and sea cucumber provide structural building blocks that are necessary to help maintain the integrity of joints and connective tissue. Vitamins A, B-6 and C, zinc, manganese, and copper act as co-factors or parts of enzymes that play a role in connective tissue formation and maintenance. Various soothing herbs, rich in polysaccharides and other constituents, assist the body’s natural mechanisms for soothing relief. Finally, N-acetyl cysteine, grape seed, beta carotene, vitamin C, zinc, selenium, horse chestnut, turmeric, and quercetin support the body’s natural antioxidant response, thereby helping maintain the health and integrity of joints and tissues (specifically cell membranes).
GLUCOSAMINE CHONDROITIN WITH MSM: HOT RESEARCHED INGREDIENTS
For added support, Source Naturals offers you a formula that combines higher potencies of the most popular joint nutrients: glucosamine sulfate, chondroitin sulfate and MSM. GLUCOSAMINE CHONDROITIN COMPLEX WITH MSM provides the same amounts of chondroitin and glucosamine shown in recent research to support healthy joints—along with MSM, vitamin C, and molybdenum, for a more powerful product. Together, these ingredients promote joint, tendon and ligament flexibility and easy joint movement.
FIBRO-RESPONSE: BIO-ALIGNED FORMULA Dealing with the muscle discomfort that affects millions in our society requires more than alleviating fatigue. FIBRO-RESPONSE influences specific body systems and tissues involved in joint health and muscular metabolism. Malic acid and magnesium, supplied in the same amounts used in recent research, help support muscular energy production, along with coenzyme Q10, lipoic acid and B-complex vitamins. MSM, copper, manganese, molybdenum, zinc, vitamin C, and beta carotene support healthy connective tissue, which is essential for proper joint and muscle function. Key ingredients, including N-acetyl cysteine and silymarin aid the liver in eliminating toxic waste from blood and tissues. Ingredients including lipoic acid, selenium, N-acetyl cysteine, and coenzyme Q10 support antioxidant defense, thereby helping to maintain tissue integrity. And ginkgo and GABA are among the ingredients that support clear focus and stress reduction.
LIFESTYLE TIPS FOR HEALTHY JOINTS: A STRATEGY FOR WELLNESSSM Healthy lifestyle habits should be part of your individual strategy for joint wellness. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, and eliminate polyunsaturated and hydrogenated oils. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: In addition to the formulas described above, Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme BROMELAIN; SAMe, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CM COMPLEX™ Cetyl Myristoleate, a fatty acid ester shown in recent research to reduce joint discomfort.