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CV Sciences, Inc. Announces Landmark Publication on the Toxicology and Safety Assessment of ... VitaNet, LLC Staff 8/9/18
New Frontiers in Enzyme Supplementation Darrell Miller 2/16/06
Nattokinase Fact Sheet Darrell Miller 12/8/05
Tru-E Bio Complex Darrell Miller 12/8/05



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CV Sciences, Inc. Announces Landmark Publication on the Toxicology and Safety Assessment of ...
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Date: August 09, 2018 09:53 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: CV Sciences, Inc. Announces Landmark Publication on the Toxicology and Safety Assessment of ...





CV Sciences, Inc. Announces Landmark Publication on the Toxicology and Safety Assessment of ...

The scientific study of the analysis of CBD oil got a major push recently. It's been almost 40 years since the last thorough toxicological safety assessment was run on a CBD oil. However, recently CV sciences had AIBMR Life Sciences Inc. perform a complete array of toxicological studies on Plus CBD oil, the company's consumer-lauded hemp cannabidiol oil. The study attested to the safety of oral consumption of the product.

The study conclusions, which have been shared in a peer-reviewed journal, attest to the fact that the oil was discovered to be non-clastogenic, non-mutagenic and non-genotoxic. A spokesperson for CV Sciences noted that the company was "thrilled" and would encourage all CBD companies to allow such studies to be conducted for their own base materials.

Key Takeaways:

  • CV Sciences Inc hired AIBMR Lifesciences Inc. to perform a full toxicological screening of CV's consumer-lauded CBD oil, specifically an extract from the base raw materials comprising it.
  • A peer-reviewed journal has published the findings, which indicate that the extract tested is non-mutagenic, non-clastogenic and non-genotoxic.
  • A spokesperson for CV Sciences indicated that the company was "thrilled" and also urged other CBD companies to have their base materials tested too.

"The toxicological assessment is the first known published data of its kind since the 1980 Rosenkrantz et al.’s publication with respect to toxicology data on CBD, Cannabichromene and hashish oil."

Read more: http://markets.businessinsider.com/news/stocks/cv-sciences-inc-announces-landmark-publication-on-the-toxicology-and-safety-assessment-of-base-material-of-its-pluscbd-oil-products-1027104828

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New Frontiers in Enzyme Supplementation
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Date: February 16, 2006 04:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New Frontiers in Enzyme Supplementation

New Frontiers in Enzyme Supplementation

By Nick Rana, CN, NOW Quality Assurance

Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible NON-GEnetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.

Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.

The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.

Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.

Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.

The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.

TECHNICAL NOTES:

Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).

While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).

The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.



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Nattokinase Fact Sheet
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Date: December 08, 2005 05:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nattokinase Fact Sheet

Nattokinase Fact Sheet

Neil E. Levin, CCN, DANLA 8/8/05

LIKELY USERS: People seeking to support heart health and healthy circulation.1-6

KEY INGREDIENTS: Nattokinase, an enzyme

STRUCTURE/FUNCTION USE: Nattokinase is an enzyme isolated from Natto, a traditional Japanese fermented soy food. Natto has been consumed safely for thousands of years for its numerous health benefits. More recently, both clinical and non-clinical studies have demonstrated that Nattokinase supports heart health and promotes healthy circulation. Each serving of NOWR Nattokinase provides 2,000 FU (Fibrinolytic Units) to help keep already healthy levels of blood clotting factors within a normal range. 1-6

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: An assay of 2,000 FU (Fibrinolytic Units) is equivalent to 160 IU on the Urokinase assay. The FU assay measures Nattokinase activity by using the fibrin plate method and measuring the absorption of released low-molecular weight substances.7 NOW Nattokinase is made from NON-GE (NON-GEnetically engineered) bacteria (Bacillus subtilis var. Natto) grown on NON-GE soybeans and standardized on a base of NON-GE, corn-derived maltodextrin.

SERVING SIZE & HOW TO TAKE IT: Take one vegetarian Vcap once or twice a day between meals (without protein).

COMPLEMENTARY PRODUCTS: Vein SupremeTM, Tru-E Bio ComplexTM, Pycnogenol®, garlic, and cayenne

CAUTIONS: None.

SPECIFIC: People with blood coagulation disorders or who take anticoagulant (“blood thinning”) medications (including aspirin) should consult a physician before use. Do not take if prone to bleeding. Unlike some other brands, NOWR Nattokinase contains no Vitamin K (K1 or K2), which would enhance clotting.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S (1995) Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull 18(10):1387-1391
2. Sumi H, Hamada H, Nakanishi K, Hiratani H (1990) Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 84(3):139-143.
3. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K (2003) Dietary Supplementation With Fermented Soybeans Suppresses Intimal Thickening. Nutrition 19:261-264.
4. Suzuki Y, Kondo K, Matsumoto Y, Zhao B-Q, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K (2003) Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 73:1289-1298.
5. Ito H, Suzuki T (2002) Effect of oral administration of nattokinase extract on blood mobility. Society of Analytical Bio-Sciences 25(4):1-5.
6. An Open Clinical Pilot Study to Evaluate the Safety and Efficacy of Natural Super Kinase as an Add-On Oral Fibrinolytic Agent to Low Molecular Weight Heparin and Anti-Platelets in Acute Ischaemic Stroke. (no authors listed) (2004)
7. Method: J of Agri Food Chem, Vol 48 (2000) P3, 210-213, 216



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Tru-E Bio Complex
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Date: December 08, 2005 04:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Tru-E Bio Complex

Tru-E Bio Complex TM

Neil E. Levin, CCN, DANLA 7/27/05

LIKELY USERS: Most Americans are deficient in Vitamin E 8,9,10; People needing superior antioxidant protection3,5,6; People needing cardiovascular or cholesterol support27,30,31; People needing nervous system support7; Those wanting healthier skin6; Diabetics may need additional Vitamin E24 KEY INGREDIENTS: Tocopherols from IP-Preserved, non-GMO Soy; Tocotrienols and tocopherols from non-GMO virgin palm; Tocotrienols from non-GMO annatto seed

MAIN PRODUCT FEATURES: NOW Tru-E Bio ComplexTM is a unique biologically balanced, patent-pending formula designed to provide optimal Vitamin E activity. This product features 100% natural, NON-GEnetically Modified sources of all 8 isomers (forms) of the Vitamin E “family” in ratios similar to what is found in a healthy diet. It provides the superior benefits of foodsource Vitamin E versus those obtained from traditional E supplements.

NOW® Tru-E Bio ComplexTM has been carefully blended to supply high levels of the natural gamma and delta “desmethyl” forms of both tocopherols and tocotrienols. This is important because recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues. This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants. This science-based natural Vitamin E supplement is unlike any other and the first to combine all of these benefits in one convenient non-GMO formula! 25-32

Recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues.1-4, 25-32

This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants.1,4-7

Levels of Vitamin E above 100 IU daily are associated with decreased risk of coronary heart disease and certain types of cellular disorders, as well as enhancement of immune function. These vitamin E intakes are considerably above levels obtainable from diet alone. 11,12,13

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:

This is a product that is Patent Pending, based on months of research into optimal forms, potencies and ratios of the 8 isomers of natural Vitamin E. All of the Vitamin E formulas currently on the market use potencies of tocopherols that are very dissimilar to what is found in a healthy diet, with either too low or too high amounts of gamma and alpha tocopherols for a good balance. Some do not even include tocotrienols.

All of the Vitamin E formulas on the market that do contain a mixture of tocopherols and tocotrienols tend to use either 400 IU or 100 IU of alpha tocopherol, some as little as 50-60 IU, combined with varying doses of gamma tocopherol. We have reduced the alpha tocopherol from the standard 400 IU per capsule to 200 IU, allowing more gamma tocopherol in the capsule to follow the typical ratio in a healthy diet. Other brands either cut the alpha tocopherol too low (to keep the gamma tocopherol at a good level) or else cut the gamma and other tocopherols too low (to keep the alpha tocopherol at 400 IU).

Special care was used to maintain a certain ratio of tocopherols and of tocotrienols that is unique and from natural sources. Our formula is also unique in mixing sources of tocotrienols to achieve our desired balance, whereas other formulas include only one source, despite the dissimilarity of the mixture to what is found in a healthy, varied diet.

Other formulas use either Vitamin E derived from genetically engineered soybeans and/or add soybean oil from similar sources as a base. NOW uses expensive non-GMO sources, the first formula to do so, with no soybean oil added. This enhances the quality of our product compared to every other formula on the market.

We use the expensive virgin palm oil rather than the cheap palm distillates because it is un-denatured and contributes additional, valuable oil nutrients such as CoQ10, Squalene and Sterols. Also, much of the clinical research done on tocotrienols was done using virgin palm oil sources 32

Natural Vitamin E is more effective than synthetic Vitamin E.14 - 23

SERVING SIZE & HOW TO TAKE IT: One or two capsules per day, preferably with meal(s). Oils enhance the absorption of Vitamin E. Concentrated fiber supplements may decrease the absorption of Vitamin E, so it is best not to take both at the same meal.

SYNERGISTS: Antioxidants (Alpha Lipoic Acid, Vitamin C Complex, Pine or Grapeseed Extracts, VitaBerry Plus+, CoQ10, etc.), Plant Sterols, Fish Oil, Flaxseed Oil, GliSODin, EGCg Green Tea Extract, Lecithin, Nuts and Seeds

CAUTIONS: None.

SPECIFIC: Aspirin and blood thinners should not be taken with Vitamin E without physician’s approval. Many other pharmaceutical drugs deplete Vitamin E, adding to the likelihood that a person will be deficient.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

REFERENCES:

1. Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) g-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74:714-722.
2. Schneider C (2005) Chemistry and biology of vitamin E. Mol Nutr Food Res 49(1):7-30.
3. Pfluger P, Kluth D, Landes N, Bumke-Vogt C, Brigelius-Flohe R (2004) Vitamin E: underestimated as an antioxidant. Redox Rep 9(5):249-254.
4. Liu M, Wallin R, Saldeen (2002) Effect of mixed tocopherols on ecNOS, SOD, and PKC in leukocytes in human subjects. Nutr Res 22:1253-1263.
5. Saldeen T, Li D, Mehta JL (1999) Differential Effects of a- and g-Tocopherol on Low-Density Lipoprotein Oxidation, Superoxide Activity, Platelet Aggregation and Arterial Thrombogenesis. J Am Coll Cardiol 34:1208-1215.
6. "Packer L, Valacchi G. (2002) Antioxidants and the response of skin to oxidative stress: vitamin E as a key indicator. Skin Pharmacol Appl Skin Physiol 15(5):282-90."
7. Sen CK, Khanna S, Roy S. (2004) Tocotrienol: the natural vitamin E to defend the nervous system? Ann N Y Acad Sci 1031:127-42.
8. Dial S, Eitenmiller RR. 1995. Tocopherols and tocotrienols in key foods in the U.S. diet. In: Ong ASH, Niki E, Packer L, eds. Nutrition, Lipids, Health, and Disease. Champaign, IL: AOCS Press. Pp. 327–342.
9. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000). Institute of Medicine
10. JASPREET K.C. AHUJA, JOSEPH D. GOLDMAN, and ALANNA J. MOSHFEGH. Current Status of Vitamin E Nutriture. Ann NY Acad Sci 2004 1031: 387-390.
11. Bauernfeind, J. Tocopherols in Foods. In: Vitamin E: A Comprehensive Treatise. Marcel Dekker, Inc., New York and Basel, pp. 99-167, 1980.
12. Horwitt, M.K. The Promotion of Vitamin E. J. Nutr. 116:1371-1377, 1986.
13. Weber, P., Bendich, A. and Machlin, L.J. Vitamin E and Human Health: Rationale for Determining Recommended Intake Levels. Nutrition 13:450-460, 1997.
14. Acuff RV et al. Am. J. Clin. Nutr. 1998;67:459-64
15. Acuff RV et al, Am. J. Clin. Nutr. 1994, 60:397-402
16. Behrens, W.A. and Madere, R. Tissue Discrimination between Dietary RRR-Alpha- and All-Rac-Alpha-Tocopherols in Rats. J. Nutr. 121:454-459, 1991.
17. Burton G et al, Am. J. Clin. Nutr. 1998,67:669-84
18. Ferslew, K.E., Acuff, R.V., Daigneault, E.A., Woolley, T.W. and Stanton, P.E. Pharmacokinetics and Bioavailability of the RRR and All Racemic Stereoisomers of Alpha-Tocopherol in Humans after Single Oral Administration. J. Clin. Pharmacol. 33:84-88, 1993.
19. Horwitt, M.K. The Promotion of Vitamin E. J. Nutr. 116:1371-1377, 1986.
20. Ogihara, T., Nishida, Y., Miki, M. and Mino, M. Comparative Changes in Plasma and RBC Alpha-Tocopherol after Administration of dl-Alpha-Tocopheryl Acetate and d-Alpha-Tocopherol. J. Nutr. Sci. Vitaminol. 31:169-177, 1985.
21. Traber M et al, FEBS Letters 1998,437:145-148
22. Traber MG, et al. J Lipid Res. 1990,31(4):675-85
23. Weiser, H. and Vecchi, M. Stereoisomers of Alpha-Tocopheryl Acetate. II. Biopotencies of All Eight Stereoisomers, Individually or in Mixtures, as Determined by Rat Resorption-Gestation Tests. Internat. J. Vit. Nutr. Res. 52:351-370, 1982.
24. Polidori MC, Mecocci P, Stahl W, et al. Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab Res Rev 2000;16:15–9.
25. Cooney RV, Franke AA, Harwood PJ, Hatch-Pigott V, Custer LJ, and Mordan LJ. gamma-Tocopherol Detoxification of Nitrogen Dioxide: Superiority to alpha-Tocopherol. PNAS 1993; 90: 1771-1775.
26. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr. 2005 Feb;81(2):508-14. PMID: 15699242
27. Inokuchi H, Hirokane H, Tsuzuki T, Nakagawa K, Igarashi M, Miyazawa T. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem. 2003 Jul;67(7):1623-7. PMID: 12913317
28. Kline K, Yu w, Sander BG, et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. (1999), Nutr Cancer, 33 : pp : 26 – 32
29. The Chicago Health and Aging Project, Martha Clare Morris, Denis A Evans, Christine C Tangney, Julia L Bienias, Robert S Wilson, Neelum T Aggarwal and Paul A Scherr. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. American Journal of Clinical Nutrition, Vol. 81, No. 2, 508-514, February 2005
30. Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993 May 25;268(15):11230-8. PMID: 8388388
31. Pearce BC, Parker RA, Deason ME, Qureshi AA, Wright JJ. Hypocholesterolemic activity of synthetic and natural tocotrienols. J Med Chem. 1992 Oct 2;35(20):3595-606. PMID: 1433170
32. Soelaiman IN, Ahmad NS, Khalid BA. Palm oil tocotrienol mixture is better than alpha-tocopherol acetate in protecting bones against free-radical induced elevation of bone-resorbing cytokines. Asia Pac J Clin Nutr. 2004 Aug;13(Suppl):



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