Search Term: " Nitric "
Can aloe vera be used to treat sepsis?
May 10, 2019 10:42 AM
Aloe vera can be used for plenty of skin conditions, but new evidence suggests it could be used for blood infections, because of the metabolites in the plant. A Chinese and Japanese study looked at this using mice, and found that aloe metabolites suppressed inflammation, due to reduced nitric oxide level. This is important because sepsis harms the body's own tissues and organs, and can be fatal. Aloe also has other uses, such as skin care, warding off cancer, treating digestive issues, and lowering blood sugar levels.
"After using various tests to determine inflammation, the Chinese and Japanese research team found that aloe metabolites suppressed the expression of inducible nitric oxide synthase (iNOS) and mitogen-activated protein kinases (MAPKs). Aloe metabolites also decreased the production of proinflammatory cytokines and nitric oxide."
Read more: https://www.naturalnews.com/2019-04-17-can-aloe-vera-be-used-to-treat-sepsis.html
Aged garlic is incredibly good for your heart
May 03, 2019 04:18 PM
Natural compounds found in aged garlic can be very beneficial to cardiac health. For example, a 2016 Los Angeles Biomedical Research Institute study on subjects with metabolic syndrome found that aged garlic extract reduced both the accumulation of new plaque within the arteries and the total amount of plaque present as well. Additional research suggests that aged garlic extract can help reduce C-reactive protein and interleukin levels. The polysulfides in garlic also support greater production of the nitric oxide that helps keep your blood vessels supple, reducing another cardiac risk factor.
"The LA BioMed researchers concluded that garlic not only decreased the amount of plaque in the arteries. The extract also stopped new plaque from appearing in the blood vessels. (Related: Aged garlic extract balances your cholesterol levels, study finds.)"
Read more: https://www.naturalnews.com/2019-03-09-aged-garlic-is-incredibly-good-for-your-heart.html
Cocoa has profound healing properties, beating even acai andblueberries
April 02, 2019 02:02 PM
Cocoa is not only delicious, but also has healing properties. Cocoa is rich in antioxidants which are also found in berries, tea and wine. The antioxidants are known to help inflammation and blood pressure levels. Flavanols are also found in cocoa. These are correlated to improved heart function by controlling the levels of nitric oxide in your blood. Cocoa may even help with side effects of Type II Diabetes, brain health and reducing your risk of cancer.
"While cocoa does possess anti-diabetic properties, it does not mean that eating more chocolate will provide even more anti-diabetic properties. To a certain extent, the intake of cocoa can improve glucose metabolism and insulin sensitivity."
Read more: https://www.naturalnews.com/2019-01-29-cocoa-has-profound-healing-properties.html
Health Benefits of Cinnamon
January 13, 2019 04:10 PM
Cinnamon is not only a delicious spice that can be added to a variety of dishes, but it also comes naturally equipped with several health benefits. Cinnamon is a natural antioxidant, giving it the ability to prevent against certain metabolic disorders, as well as diseases that are brought on by aging. It is also an anti-inflammatory by how it can aid in the production of nitric oxide, a primary contributor in helping the body combat inflammatory responses.
"Cinnamon is known to possess anticarcinogenic, antioxidant, anti-inflammatory, antidiabetic, and antimicrobial properties."
Read more: https://www.news-medical.net/health/Health-Benefits-of-Cinnamon.aspx
Curcumin protects cardiac tissue from combined oxidative stressinduced by diabetes and nicotine
January 07, 2019 03:55 PM
Patients who are diabetic or engage in tobacco smoking can unfortunately face health concerns in regards to oxidative stress that impacts their cardiovascular function. A lot of this oxidative stress is referred to as hyperglycemia-induced, and it is shown to be less prevalent when curcumin is consumed. In one particular study, the administration of the curcumin actually prevented the oxidative stress due to diabetes and tobacco smoking altogether. This could show great promise for those struggling with insulin levels and tobacco addiction.
"Research has found that curcumin can protect cardiac tissues from the combined oxidative stress induced by diabetes and nicotine."
Read more: https://www.naturalnews.com/2018-12-20-curcumin-protects-cardiac-tissue-from-combined-oxidative-stress-induced-by-diabetes-and-nicotine.html
Pumpkin Seeds: The Antioxidant Seeds that Combat Diabetes, HeartDisease & Cancer Cells
December 11, 2018 11:22 AM
Pumpkins don't get the attention of other vegetables. Even during their season, it's the pies made from the meat of the pumpkin that get most of the table time. However, pumpkin seeds should not be relegated to the trash. Like sunflower, and other seeds, they make good snacking. And they have a lot of health benefits for users. For example, they're full of antioxidants, like many veggies, which makes them useful for warding off many unwanted conditions. They're good for hearts and for leveling blood sugar. Study has shown that the seeds benefit the heart in an array of ways. Nitric oxide is enhanced, while blood pressure and cholesterol are lowered. The seeds are protein-packed and fiber-rich, which means that sugar is absorbed more slowly. The seeds are also rich in tryptophan and magnesium, known to promote optimal sleep. Study has also shown that sperm count was enhanced and abnormalities were improved when rodent subjects were given pumpkin seeds. Certain seed properties may have anti-cancer effects as well, even the ability to help with overactive bladder syndrome.
"However, there are many benefits of pumpkin seeds that make them a worthy addition to your diet, both during the holidays and all year round."
Read more: https://draxe.com/pumpkin-seeds/
Bifidobacterium Lactis: The Bacterium That Could Help You LoseWeight & Fight Inflammation
October 10, 2018 03:26 PM
The probiotic Bifidobacterium lactis, or B. lactis, is a powerhouse for gut health. Why is this strain of bacteria so important? One study published in 2015 showed that B. lactis could improve unpleasant and painful symptoms associated with poor gut motility, dysbiosis, and GI hypersensitivity. B. lactis is definitely one of the “good guys” of the gut bacteria world because it contributes to a healthy and balanced microbiome, which positively affects balanced blood sugar and optimal weight maintenance.
"A particular strain of B. lactis, known as HN019, has been shown to have a significant impact on those with metabolic syndrome. This probiotic had beneficial effects on inflammation, nitric oxide metabolites, and antioxidant measurements, and the authors of the study stated that if their results are confirmed, supplementation with this probiotic should be considered further."
Read more: https://www.mindbodygreen.com/articles/bifidobacterium-lactis-weight-loss-inflammation
Is Your Blood Pressure Out Of Control? Eat beet roots!
Today, one of the most serious conditions that people face is hypertension, or as it is commonly known, high blood pressure. This is grave condition, that if not checked, can result to fatalities. This condition is mostly found in people who are over 40 years. However, it is not unlikely to find a teenager with hypertension. This is a worrying trend which means that something must be done to prevent it. Luckily, there is a simple solution that people can apply to control this condition.
To start with, it is important to understand what causes the condition so that one may know how to combat it. High blood pressure is primarily caused by the constriction of the arteries which makes it hard to pump blood. The arteries are thinner than the veins and this means that the blood in them is at a higher pressure than in the veins. Due to the narrowness, they are able to pump blood faster and for longer distances.
When a person feeds on unhealthy food that is rich in cholesterol and other harmful substances, this causes a deposition of the harmful substances on the endothelium (the interior surface of the arteries). When this happens, the arteries become more constricted thus increasing the pressure of blood that flows in them (hence the term high blood pressure).
When the pressure increases, there is insufficient supply of blood to vital organs of the body like the brain. When the brain is not supplied with enough nutrients in the blood, this could lead to brain damage or stroke that may cause paralysis. Again, to ensure enough blood gets to the brain, the heart is forced to pump blood faster. This overworks the heart which may lead to heart attacks. Heart attacks are usually fatal.
There is therefore a need to unblock the heart vessels to ensure that blood flows easily. Nitric oxide is one of the best known remedy to people suffering from high blood pressure. It helps lower the blood pressure by unblocking the arteries. It has numerous benefits to the body especially in lowering the blood pressure. Arteries are able to release Nitric oxide but as one advances in age, their effectiveness diminishes with time.
Beet roots are a great source of Nitric oxide. Eating lots of them will help supply your body with the Nitric oxide it needs to unblock the arteries and thus lower the blood pressure. The whole beet root plant including the leave and the roots provides are rich source of Nitric oxide. For those who don’t like eating it raw or cooked, they can juice it and still get the nutrients. Apart from lowering hypertension, beet roots are also known to fight against cancer. These are enough reason why anyone should increase their intake of beet roots whether or not they are suffering from high blood pressure.
Beet roots juice is available in stores which could act as a powerful supplement to combat hypertension.
What are the Benefits of Jiaogulan
July 10, 2014 08:20 PM
What is a jiaogulan
Jiaogulan is also known as Gynostemma pentaphyllum is an adaptogenic herb and the vine from the Cucurbitacea family of plants that grows naturally in Asia, and most specifically in China, Japan as well as in Korea. This plant is related to plants such as the watermelon, pumpkin, cucumber as well as to the gourds. Praised in China as xiancao, the Jiaogulan herb is an incredibly useful life giving plant, the herb of immortality with a powerful adaptogenic capabilities and antioxidant properties. Its adaptogenic capability is derived from its components and substances that aids in revitalization thus bringing the whole body back into balance.
Benefits of jiaogulan
Generally, this plant offers numerous health related benefits with minimal side effects. To Begin with its adaptogenic capabilities, not only helps the body to resist the effects of a stressful conditions, but it also promotes the condition known as homeostasis which helps the body to achieve a state of balance through by regulating various and numerous internal body process. To be more specific, the Jiaogulan herb has adaptogen properties that address both the excess output and the deficiency in the body immune and the endocrine systems. Basically, the adaptogens and the saponins in this plant not only aids the body to regulate itself, which is indeed a key factor in the prevention of diseases and defects such as diabetes, stroke, insomnia, cancer, heart attack, hypertension, atherosclerosis, hormonal imbalance as well as prevention of the high blood pressure, aiding in the proper function of the cardiovascular as well as helping to regulate the cholesterol level in the body among many more.Additionally, Jiaogulan has some collective chemical compounds known as gypenosides.These gypenosides compounds offer protection against free radical elements and thus against oxidative stress within the brain, which are known to be the main trigger of the Parkinson disease. Their antioxidant capability improves immunity, reduces the effects of aging and speeds the rate of muscle recovery. This herb also has the capability to release Nitric oxide, which helps to relax the body blood vessels, its antioxidant compounds ensures you leave free of the radical compound hence your longevity. If you need to build your body mass, muscles,your strength as well as to reduce fatigue, then this herb will be so suitable for you. Finally, the the Gynostemma also has important minerals, vitamins,amino acid and traces of minerals, which of course is generally essential to the body.
A Guide About beet roots.
April 17, 2014 10:47 PM
History of beet
Beets are certainly historical. Originally, the sweet reddish beetroot that majority of people think of to be a "beet" today had not been cultivated till era involving historical Rome. By the exact nineteenth century, however, the natural sweetness of beets had become appreciated and beets grew to become used as a method to obtain sugar.
Health improvements about beet root base.
a) Lower Blood Pressure
Drinking beet juice can assist to lower blood pressure. One study discovered which drinking a single wine glass concerning beet juice minimal systolic blood pressure by simply typically 4-5 items.
b). Enhance Ones Stamina
If you choose a boost to let it become through your current subsequent training, beet juice may again prove valuable. Those who consumed beet liquid before exercise had an opportunity to exercise for approximately aid 16 pct longer. 4 The leading benefit is thought to also be connected with nitrates turning in Nitric oxide, which can slow up the oxygen charge connected with low-intensity exercise and moreover enhance tolerance in order to high-intensity determine.
c) Anti-Cancer Qualities
The powerful phytonutrients that supply beets their strong crimson color can assist to ward off melanoma. Research has found which beetroot remove reduced multi-organ tumor formations in lots of different animal designs when administered in water, for instance, while beetroot extract is normally being studied for easy use within treating human pancreatic, bust line, and prostate varieties of cancer.
d) Rich inside Valuable Nutrients and Bedding
Beets are excessive throughout immune-boosting nutritional C, dietary linens, and essential minerals for instance potassium (essential intended for healthful nerve along with muscle function) along with manganese (which is useful for your bones, liver, kidneys, and in addition pancreas). Beets in addition support the vitamin foliate, which helps slow from the risk of beginning complications.
Astaxanthin Protects The Eye And More!
November 13, 2013 02:52 PM
Astaxanthin is a carotenoid that is commonly found in the marine environment. It is naturally found in salmon, krill, trout, crayfish, shrimp, crustaceans and yeast. It is the chemical that is responsible for the red color in cooked shellfish and salmon meat. The algae Haematoccus has the richest natural source of astaxanthin.
Astaxanthin can also be produced synthetically, but due to the synthetic product consisting of different steriosmers it is not preferred to be used in some cases.
Unlike beta-carotene it has two more oxygenated groups on each of its ring structure, these additional functional groups make it a highly potent antioxidant and give it a configuration that is more polar than that of other carotenoids. Vitamin E has been known as the strongest antioxidant both in topical use in cosmetics and in internal use, but research has shown that astaxanthin has a greater antioxidant strength than Vitamin E. For example in the quenching of singlet oxygen it has an antioxidant strength five hundred times stronger than Vitamin E.
Unlike many other antioxidants it has the ability of crossing the blood-brain barrier and enter into the eyes, brain and central nervous system (CNS). Most diseases of the CNS and eye are caused by increased generation of free radicals or by a decrease in the ability to remove free radicals from the body. Some of the diseases that are caused by problems with inflammation and oxidation include Glaucoma, Cataracts, and Huntington’s disease. These can be prevented by taking astaxanthin.
It has anti-inflammatory properties that are related to its strong antioxidants properties. It suppresses some of the inflammatory mediators such as, prostaglandin E-2 (PGE-2), tumor necrosis factor –alpha (TNF-a), and Nitric oxide. Unlike other anti-inflammatory drugs like acetaminophen that can damage the liver and aspirin that may cause stomach bleeding, astaxanthin doesn’t have any side effects.
In people suffering from rheumatoid arthritis and carpal tunnel syndrome it has the ability of reducing pain. Studies have shown that it is able to reduce pain in rheumatoid arthritis by 40% after 8 weeks of continuous use.
It prevents Ultra Violet induces oxidative stress of the skin and prevents the photo aging of the skin. It prevents UV induced formation of wrinkles and collagen degradation in the skin. It may be applied on the skin or taken orally.
In people participating in sports it eliminates the soreness of joints after exercise, and reduces the pain caused by inflammation. This enables athletes to train harder and as a result increase their endurance, skill, and strength. This is through its ant-inflammatory and ant-oxidant effects in the mitochondria (energy producing organelle).
It strengthens the immune system, research by scientists has shown that it causes increase in production of T cells, stimulates the proliferation of lymphocytes, amplify the cytotoxicity of natural killer cells, decrease damage of DNA, and increases significantly delayed type hypersensitivity syndrome.
It prevents heart disease and reduces the risk of people already suffering from heart disease form getting a stroke or heart attack. It improves the blood lipid profiles by increasing HDL (high density lipoprotein) and decreasing LDL (low density lipoprotein).
The liver main function of the liver and kidney is the detoxification and removal of harmful substances in the body. These activities lead to the formation of free radicals. Astaxanthin being a strong antioxidant helps by destroying these free radicals hence it eliminates their oxidative effects.
As a result of its immune benefits Astaxanthin also has anti-tumor properties and as a result it prevents the development of cancer. Its prevention of cancer is also caused by its antioxidant properties and by it regulating gene expression.
Can Melatonin Be Used For Fibromyalgia?
December 28, 2012 04:19 PM
Fibromyalgia is a condition that may be very frustrating and has no known cure currently. Due to its complexity and also the number of symptoms that occur during an infection with fibromyalgia, one may be moody, anxious, depressed or irritable. Melatonin, a natural hormone which controls sleep patterns, can help relieve some symptoms of fibromyalgia and promote one's feelings of well-being.
Melatonin hormone is produced by the brain's pineal gland. It is majorly responsible for controlling the sleep-wake cycle; called the circadian rhythm. The secretion of melatonin is influenced by exposure to light. Whenever it gets dark, melatonin production rises. Conversely, during exposure to sunlight, the production of melatonin is lowered. Several people employ the use of melatonin supplements to promote symptoms of insomnia, since it can aid to reset one's body clock and even make it easier to fall and stay asleep.
How melanin treats Fibromyalgia
Disturbances of sleep and the frequent disruption of circadian rhythms occur during fibromyalgia. Melatonin has always been proven to synchronize the circadian rhythms and promote the quality of sleep. Excess damage by free-radicals is quite common in fibromyalgia patients. Melatonin as well as its metabolites have been discovered to be potent scavengers of free radicals and indirect antioxidants.
Elevated Nitric Oxide In Patients
Some studies have shown that synthesis of Nitric oxide is elevated in fibromyalgia patients. Melatonin acts as a potent inhibitor of a rate-limiting enzyme in the production of Nitric oxide. Depression is at times a symptom or maybe an overlapping fibromyalgia condition.
Melatonin As An Antidepressant:
Melatonin has also been proven to be an antidepressant. There is a component of melatonin that has been synthesized in the pharmaceutical industry and is now being enhanced as an antidepressant. Lyrica, antiepileptic drugs, have been proven to be effective in the treatment of fibromyalgia. Melatonin has been found to work as an antiepileptic too.
Niacin And Niacinamide?
November 18, 2012 10:32 AM
Niacin Vs Niacinamide
Niacin also known as nicotinic acid is an organic compound and it is one of the essential human nutrients. Niacin deficiency can result to pellagra. It is also used for reducing cardiovascular issues. A chemist called Hugo Weidel first described niacin in 1873 in his studies of nicotine in the oxidation of nicotine using Nitric acid. The name niacin was derived from nicotinic acid + vitamin.
Niacinamide is also known as nicotinamide or nicotinic acid amide. It is the amide of niacin. Niacianamide is part of B-vitamin and it is water soluble. Niacinamide is derived from niacin. These two are components of B3-vitamin and they are often used as supplements interchangeably. However, there are some critical differences between these two vitamin B3 components. Niacinamide is derived from niacin and the body is able to convert niacin into niacinamide.
Niacinamide can also be made by our body from an amino acid known as trytophan which is usually present in animal foods. A chemical compound known as an amide is what makes niacinamide. Amide is defined by a nitrogen atom which is combined with a carbonyl group or C=O. Therefore, the main distinction between these two components is that niacinamide is a derivative of niacin.
Different Pharmacological Properties
Although the two are used interchangeably, they have different pharmacological properties. Their physical effects on the body also differ and people who are sensitive to their effects may prefer to use one over the other. Their usefulness in treating different conditions for instance high cholesterol, circulatory problem and osteoarthritis can also differ. Because of the pharmacological properties difference in niacin and niacinamide, different people can have different physical reactions when they take one as opposed to the other.
High niacin doses can cause flushing a condition that causes blood vessels to widen. This makes the capillaries under the skin to expand to allow more blood to flow making the skin to become red and itchy. Niacinamide does not have the effect of skin flushing and that is why it is preferred over niacin in the treatment of pellagra, a condition that results due to lack of vitamin B3. The only affect that niacinamide may cause is excessive sweating.
Niacin And Cholesterol
Niacin on the other hand it is preferred in the treatment of high cholesterol levels while niacinamide is not preferred in this treatment. This is because since niacinamide is a derivative of niacin, the cholesterol lowering properties in niacinamide are inhibited. Niacin is also preferred in treating circulatory problems because of its effects on the blood vessels and the role it plays in lowering high cholesterol levels hence preventing hardening of the arteries.
This in addition reduces the risk of heart attacks. On the other hand, Niacinamide may also be preferred for treating osteoarthritis and diabetes. The two can be used in treating physical and emotional stress. Either niacin or niacinamide may be used for treating anxiety and depression. For these two components of Vitamin B3 to be effective, doctors recommend that they ought to be taken in combination with Vitamin B1, B2 and C.
The Health benefits of L-Arginine
June 08, 2012 08:10 AM
What is L-Arginine?
L-Arginine, also referred to as Arginine, is a non-essential amino acid-it's produced naturally in the body-and it is vital for the normal functioning of pituitary gland. This substance comes from natural sources such as nuts, sesame seeds, sunflower seeds, popcorn, chocolate, brown rice, raisins, carob, oatmeal, gelatin desserts, protein rich foods, and whole wheat bread. Men, whose seminal fluids consist of up to 80 percent of this amino acid, especially need L-Arginine as a deficiency could cause infertility. L-Arginine is not only obtained from food sources but through supplementation as well. As we age, the production of this amino acid decreases in the body and this is thought to cause many degenerative processes associated with aging. Thus, Arginine is vital for maintaining your overall health as well as sexual health.
Deficiency of L-Arginine can delay sexual maturity, impair insulin production, cause liver lipid metabolism and glucose tolerance.
Functions of L-Arginine
L-Arginine amino acid performs various functions in the body, including:
It is a component of collagen, enzymes, ejaculate, hormones, connective tissues, and skin. It plays an important role in the manufacture of protein molecules such as insulin and creatine. It's a precursor of Nitric oxide as well as other metabolites.
Health benefits of L-Arginine
Although the benefits of Arginine supplements are debated, proponents state that Arginine converts into Nitric oxide inside the body and enlarges or dilates the blood vessels. This helps better circulation and it's one of the reasons it is used to cure erectile dysfunction. This amino acid produces positive results as it enhances blood circulation, especially to the genitalia. Arginine is also a key component in sperm and seminal fluid production, so it's used to treat sterility in men. Other health benefits of L-Arginine include:
Aids in muscle-building
Helps maintain blood-sugar levels
Increases immune function
Increase fertility in females
Improves blood flow and decreases clogged arteries
Increases sperm count
Helps in liver detoxification
Maintains nitrogen balance
Promotes body fat burning
Promotes better bone density
Provides anti-oxidant properties
Reduces effects of alcohol toxicity
Reduces blood pressure
Reduces heart and vascular disease, cholesterol risk and stroke
Helps reduce body fat
Helps remove excess ammonia
Aids faster healing of wounds
L-Arginine anti-aging properties
One last benefit to note about L-Arginine is the fact that it simulates the production of human growth hormone (HGH), IGF, and testosterone. As your body ages, it produces less and less of these hormones which directly affects the aging process. These hormones are responsible for reducing body fat, keeping the skin elastic, and increasing sexual stamina. While your body won't turn into that of a teenager, taking L-Arginine supplements can make you feel and look younger.
Just as other forms of supplementation, you should take caution while using L-Arginine. This means that you have to get a doctor's approval before you take this drug. You should carefully follow the drug's instructions on dosage and frequency. As long as you take L-Arginine with care, you can greatly enhance your overall health and wellbeing.
GLUCOSAMINE: Origin and Action of Mechanism
February 06, 2012 01:08 PM
Glucosamine is an amino sugar made from glucose and amino acid glutamine. It is a monosaccharide that is found naturally in healthy joints, cartilages, ligaments, muscles and tendons. It helps in the formation and repair of cartilage and other body tissues. Glucosamine is available in the form of dietary supplements, cosmetics and sports drinks. Let us find out about the history of glucosamine and its role in repair and treatment of joint disorders.
HISTORY of GLUCOSAMINE:
Glucosamine was first discovered in 1876 by Dr. Georg Ledderhose. It was prepared by hydrolysis of chitin with Hydrochloric acid. Later on it was developed in sulphate blend. Since then, it has been studied multiple times and in multiple ways to find out its potent health benefits. It has been used clinically in Europe since 1960s. In 1971, researcher K. Karzel glucosamine HCl stimulated the production of glycosaminoglycan layer, which helps in protecting cartilages, ligaments and tendons from normal wear and tear. It became popular in United States in the mid 1990s with the publication of popular bestsellers such as 'The Arthritis Cure' by Jason Theodosakis. Now it has become the most popular selling dietary supplement with sales of $200 million per year.
Glucosamine is naturally found in the body and can be synthetically made from the natural sources of chitin that is found in sea creatures such as shells of shell fish, bones and bone marrow.
How does Glucosamine Works in reducing Joint pain?
Our body's ability to produce glucosamine decreases as we age. Hence after any kind of injury cartilage, spinal discs and joints, the body may not be able to heal optimally. Aging and glucosamine depletion in the body leads to joint degradation. However, glucosamine supplementation can support cartilage and CT-integrity limiting degeneration.
Glucosamine supplements do not work like NSAIDS, which are known to have anti-inflammatory and analgesic effects on the body. The exact mechanism of significant analgesic effect of glucosamine supplements is unknown but according to various studies, glucosamine has no effect on cyclooxygenase system. Studies have shown that glucosamine stimulates synthesis of proteoglycan in a dose dependent manner. It helps in stimulating the production of cartilaginous matrix, hence counteracting the degrading loss of cartilage in case of arthritis or injury.
Several important studies demonstrate the role of glucosamine in stabilizing cell membranes, inhibit lysosomal enzymes and reduce the generation of oxygen free radicals by macrophages. It may inhibit interleukin 1 induced Nitric oxide activity that leads to chondriotic cell death. Hence it increases aggrecanase activity that helps in preservation of proteoglycan.
Glucosamine along with Chondroitin sulphate stimulates synthesis of cartilage precursors as well as synovial fluid. They also limit the degradation of existing cartilage in any loss of joint integrity.
This non rapid acting drug has many beneficial effects in reducing the symptoms of osteoarthritis. It is a powerful joint repairing supplement that rebuilds joint cartilage. Glucosamine supplements have been thoroughly evaluated to find out any potential side-effects. However, it has been proved that it does not have any of the side-effects of NSAIDS, surgery or opiods.
Can L-Arginine Really Help with Circulation Blood Flow?
February 05, 2011 01:43 PM
The incorporation of nutrients from our diet to the parts of the human body is taken care of by the network of blood vessels that make up the circulatory system, including the distribution of oxygen. Blood flow in effect largely contributes to the effective utilization of bioactive substances from digested foods. The muscles that line the inner walls of blood vessels are responsible for healthy circulation with the aid of a substance that is catalyzed from L-arginine.
Arteries, capillaries, and veins are the three primary members of the vascular highway that forms the systematic circulation. The arteries from the heart branch out in smaller vascular tubes called capillaries, which are connected to the system of veins leading back to the heart. Blood continuously flows inside this complex loop of tubes and brings nutrition to the tissues at the end of capillaries.
Endothelium and Smooth Muscle Cells
Circulation is a vascular function regulated by the smooth muscle cells within the blood vessel walls that promote streamline flow to avoid turbulence. In a lifetime the flow may result in chaos, depending on the health of blood vessels. A special class of tissues exposed to the blood plasma known as endothelium stimulates the smooth muscle cells that make up most of the systematic circulation to perform its function. However, factors associated with aging interfere with the proper functioning of both the smooth muscle cells and the endothelium.
The human body possesses a gene responsible for the encoding of a group of enzymes that aid healthy blood flow in the circulatory system. This gene identified as Endothelial Nitric Oxide Synthase (NOS), as the name suggests, has something to do with the endothelium and the chemical compound Nitric oxide. While chronic expression of Nitric oxide in the body may lead to inflammatory diseases, this gas actually serves a focal role in preventing damage to all tissues in the human body resulting from the deprivation of blood supply.
Nitric Oxide and L-Arginine
How? Nitric oxide is produced at the right amounts by all mammals for use as a signaling agent at the cellular level. In the circulatory system, Nitric oxide is known to display vasodilator properties, that is, it brings about the relaxation of smooth muscle cells that line the blood vessel walls. Vasodilation is central to circulation and blood flow inasmuch as the widening of vascular walls leads to the flow of blood. Since Nitric oxide must be manufactured at healthy levels, it is regulated by Endothelial NOS.
However, its production depends on the availability of Arginine in the human body. The amino acid L-arginine is not synthesized at sufficient amounts at all times, and thus it must be derived from our diet. No one can really tell what conditions govern the biosynthesis of L-arginine, and for individuals who have poor nutrition, levels of L-arginine are significantly low. This is the reason why medical professionals advocate the use of L-arginine to counter vascular diseases. Supplementation of L-arginine has in fact been associated to healthy circulation.
Detoxify With L-Citrulline
April 13, 2009 03:51 PM
L-citrulline is an alpha-amino acid, first isolated from the watermelon in 1930: hence the name, citrullis being Latin for that fruit, the skin of which is rich in the substance. It is used to enhance performance in sports, particularly through aiding recovery after exercise, and also helps the liver to detoxify the blood.
It is not an essential amino acid in that it is produced by the body and need not be part of your diet. It is a precursor to arginine, which involves the sustained release of Nitric oxide in the endothelium that promotes increased flow of blood and the blood vessels as described further below. One of the biochemical pathways for its biosynthesis involves the urea cycle, whereby the toxic ammonia is detoxified into an easily excreted form through its conversion to urea.
The urea cycle consists of five reactions, and citrulline is formed in the second of these. In the first of these, ammonia reacts with bicarbonate to form carbamoyl phosphate, the phosphate coming from the two molecule of ATP used to energize the reaction. These are converted to adenosine diphosphate (ADP), and the carbamoyl phosphate then reacts with ornithine to form citrulline, which takes part in step three that eventually leads to the formation of urea.
The second way in which L-citrulline can be biosynthesized is from the oxidation of arginine, a natural amino acid. Arginine is oxidized into N-hydroxyarginine, and then into L-citrulline with the release of Nitric oxide.
So that's how it is produced in the body, but how does it help sportsmen, and what part does it play in detoxification? Its effect on recovery after exercise is connected with blood flow. Energy is created in the mitochondria that are contained in every cell off the body. Among the raw materials needed for the production of energy are glucose and oxygen: glucose obtained from the carbohydrates in your diet, and oxygen transported by the hemoglobin or red blood cells.
Both of these rely on blood flow: greater the volume of blood transported to the cells then the greater the ability of these cells to produce energy. During periods of exercise, a good supply of blood is required to provide the raw materials needed for the energy demand of the muscles involved in the exercise. Not only that however, but recovery after exercise involves the replacement of electrolytes, the glycogen used in extensive aerobic and anaerobic exercise and protein replacement, particularly where catabolism has occurred.
In order to supply these raw materials at an adequate rate, it is necessary for the flow of blood to the appropriate muscles to be sufficient. A major restriction to increase blood flow is elasticity of the blood vessels and cells. Although a healthy heart is capable of providing the necessary quantities of blood, and hence of nutrients, any restriction to the flow could cause dangerously high blood pressure.
Nitric oxide plays a signaling role in enlarging blood vessels to allow an increased blood flow when it is needed by the body. It can provide more blood to the stomach during digestion and to the muscles during exercise and recovery.
During hard exercise, Nitric oxide can act as a pump that provides blood during exercise and also during recovery. It can therefore provide more rapid gains in lean mass, increased endurance and faster muscle recovery. The way it does this is to send a signal to the smooth muscles to relax; smooth muscles such as those found in veins and arteries, so resulting in vasodilation therefore allowing increased blood flow.
It is the endothelium, the inner lining of blood vessels, which uses the Nitric oxide to provide the relaxation signal to the smooth muscles surrounding it. In fact, it is the effect of Nitric oxide that enables those living at high altitudes to develop increased stamina and speed over those at lower altitudes, and find more world records seem to be broken during athletics meetings, such as Olympic Games, held at high altitudes. This is because the production of Nitric acid is increased at higher altitudes with slightly lower oxygen levels. This is the same effect that is used by vasodilators such as amyl nitrite and Viagra that work by increasing Nitric oxide levels in the smooth muscle wall of the blood vessels.
It should not be surprising therefore, that L-citrulline should work in a similar way, since it is intimately involved in the production of Nitric oxide. Although this is now generally understood, what part does supplemental citrulline play in the body if it is a non-essential amino acid?
Supplemental L-citrulline is useful in supporting the detoxification of ammonia in the liver when supplies of ornithine carbamoyl transferase is naturally in short supply. This is the enzyme that catalyzes the reaction between ornithine and carbamoyl phosphate to form citrulline. Supplements can then help in the removal of ammonia from the blood, and also provide material for the continued production of Nitric oxide support muscular activity and its recovery after exercise.
Ammonia itself is a by-product of intensive exercise, and without the urea cycle the body would rapidly become polluted. It is a very toxic product, and causes the death of thousands of people each year. This is generally in people who suffer liver and kidney disease, and the ammonia can be broken down and excreted.
Your brain cells are particularly sensitive to ammonia, and as levels increase the effect progressively ranges from drowsiness thru tremors to coma and eventual death. Any condition, therefore, that reduces the body's capability of metabolizing ammonia is potentially very serious, and any supplement that can help prevent this is valuable.
L-citrulline is believed to help in such situations, although any condition affecting the efficiency of the kidneys or liver and that can cause toxicity due to ammonia or any other toxic substance, should be referred to your physician. It is for its effect in increasing blood flow to provide sufficient raw material, for both the energy needed for high levels of exercise and for muscle recovery, that citrulline is predominantly used as a supplement.
Glaucoma (loose your eye sight)
February 16, 2009 01:18 PM
Glaucoma is a group of diseases that affect the optic nerve and can lead to irreversible vision loss. It is usually associated with elevated fluid pressure within the eye. All forms of glaucoma can cause damage to the optic nerve and lead to vision loss, even blindness, if left untreated. About 2.2 million Americans have been diagnosed with glaucoma and as many as 2 million more could have it and not yet know. It is one of the lading causes of blindness and is expected to become more prevalent in years to come due to the growing population of older adults.
Those people who are at greatest risk for developing glaucoma are people over the age of sixty, people of African ancestry, and people with diabetes, high blood pressure, severe myopia, or a family history of glaucoma. Smokers also have an elevated risk, as do those who have sustained eye injuries or who have used steroids for an extended period of time.
About 3 percent of Americans are believed to have open-angle glaucoma, which is the most common form of this disease. Because this disorder causes no symptoms until it is quite advanced, only about half of those who have it are actually aware of it. In open-angle glaucoma, there is no physical blockage and the structure of the eye appear to be normal. However, the drainage of fluid is inadequate to keep the intraocular pressure at a normal level.
The most pronounced symptoms of open-angle glaucoma are the gradual loss or darkening of peripheral vision and a marked decrease in night vision or the ability of the eye to adjust to darkness. Other possible symptoms include chronic low-grade headaches, the need for frequent changes in eyeglass prescription, and/or seeing halos around electric lights.
A far less common, yet more serious, form of glaucoma is closed-angle glaucoma. Closed-angle glaucoma is much more dangerous than open-angle forms because it almost never manifests any symptoms until very late in the condition. By that time, vision may be irreversibly damaged.
Glaucoma probably has many causes, with many scientists believing it may be closely linked to stress and nutritional problems or disorders like diabetes and high blood pressure. Some think that excessive amounts of glutamic acid, which is a nonessential amino acid, may be involved. Glaucoma has also been linked to deficiency in Nitric oxide, which is a molecule that is critical for healthy blood vessels. Problems with collagen, the most abundant protein in the human body, have been linked to glaucoma as well. Collagen increases the strength and elasticity of tissues in the body, especially those of the eye. Collagen and tissue abnormalities at the back of the eye contribute to the clogging of the tissues through which the intraocular fluid normally drains. This results in elevated inner eye pressure, leading to glaucoma and related vision loss.
The following nutrients are considered to be very important when dealing with and preventing glaucoma: choline, essential fatty acids, glutathione, rutin, vitamin A, vitamin B complex, vitamin C with bioflavonoids, vitamin E, alpha-lipoic acid, magnesium, a multivitamin and mineral complex, and zinc. Additionally, the following herbs are helpful: bilberry, chickweed, eyebright, coleus forskohli, fennel tea, chamomile, ginkgo biloba, zinc sulfate, jaborandi, and rose hips.
To resolve issues with the eyes, one must change their diet, exercise, and take supplements and herbs like what are listed above. Medical doctors are at a loss as to how glaucoma happens but they can help stop the progression of this disease if detected early on. Always consult your doctor before adding vitamins and herbs to your diet, vitamins and herbs are available at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
L-Arginine An Amino Acid Essential Or Not You Be The Judge?
January 06, 2009 04:01 PM
L-Arginine is an amino acid that is one of 20 needed by the body for its existence. To some, it is not what is known as an essential amino acid, since it can be biosynthesized by the body, but arginine is termed a conditionally essential amino acid in that we must include some in our diet because our biochemistry does not produce all that our body needs, particularly during the growing years.
Amino acids are the building blocks of life, and are the units from which proteins and ultimately our DNA are built. In fact DNA contains the blueprints for every protein used by our bodies, including all the enzymes without which our biochemistry could not occur. When a supply of a particular protein is needed, the DNA template provides the sequence of amino acids needed to produce it.
Of the 20 amino acids we need, only 10 can be produced by our body: the other 10 must be included in our diet and are termed 'essential' because they are an essential part of our diet, just as vitamins and minerals are. Without an adequate supply of essential components, we cannot survive, and if the essential amino acids are depleted in our diet then the body will break down muscle tissue to release them.
Although L-arginine is termed a 'conditionally' essential amino acid, it is included by many among the 10 regarded as being essential. Hence, depending upon who you read, it can be either essential or non-essential. That is because, as inferred earlier, arginine is needed for growth and development, and there is insufficient in the diet to meet these needs. Therefore, while it is essential in cases where growth is still taking place, it is not in those where normal growth is complete.
Proteins are essential for all animal life, forming not only the enzymes, or biochemical catalysts, but also muscles and DNA among other bodily tissues. Protein is also a necessary part of our diet, and it is from protein, animal or vegetable, that we get the amino acids in our diet. L-arginine is one of these, being available from all meats and seafood’s, and vegetables rich in protein such as soy, seeds, nuts and grains.
So what does arginine do for us, quite a lot in fact, many of its functions being related to our health? Arginine plays an important role in the healing of wounds, especially bone, assisting the immune function, decreasing blood pressure and speeding up the repair time of tissue. However, it possesses other properties such as increasing muscle mass, helping to increase male fertility and improving the circulation.
It also helps to remove ammonia from the body, and is a precursor for the biosynthesis of Nitric oxide (NO2). It is in the way that L-arginine works with the nitrogen stores of the body that we will focus on here, prior to touching on its other properties.
L-Arginine transports, stores and excretes nitrogen, and used biochemically to manufacture Nitric oxide. This oxide of nitrogen plays a very important role in your body, and is produced in every cell of your body. Nitric oxide helps in the dilation of your blood vessels, allowing a reduction in blood pressure, better circulation and helping to prevent a mans man-hood dysfunction, all of which are due to its relaxing effect on smooth muscle contraction and the promotion of the increased blood flow necessary for men and their functions. It is also important to your immune system and nervous system.
It works in a similar way to the effect of nitroglycerine on the heart: this is converted in the body to Nitric oxide which relaxes the blood vessels and so reduces the amount of work needed by the heart. The way in which L-arginine forms Nitric oxide is by the action of the enzyme Nitric oxide synthase.
The amino acid is also an important component of the Citric Acid or Kreb's cycle, where it reacts with ammonia which is a toxic by-product in the generation of energy in the mitochondria. Ammonia is converted to urea by L-arginine and excreted from the body. This is another way in which L-arginine is involved in the storage and use of nitrogen-containing compounds in your biochemistry.
It was mentioned earlier that arginine is an essential amino acid for children. Studies have indicated that it supports the release of the human growth hormone from the pituitary gland although the amount released through supplementation of the amino acid varies widely between individuals. The growth hormone maintains the production of proteins and muscle tissue in the body cells. This reduces as we age, and arginine becomes non-essential, the smaller amounts needed in our biochemistry being manufactured by the body.
The anabolic effect of the supplement is believed to increase the effectiveness of exercise intended to increase muscle bulk and reduce the percentage of body fat, and many take L-arginine as a supplement while undergoing such anabolic fitness and exercise programs. It is normally best to start with low supplement levels and work up due the potential side effects (diarrhea and nausea).
Arginine is an important component in the body's healing mechanisms for both tissue and bone, and studies have confirmed accelerated healing of wounds and fractures with arginine supplementation. Although the mechanism by which this occurs is not yet understood, there is evidence that it may be connected with the Nitric oxide pathway and increased blood flow, and also with its effect on the immune system in reducing inflammation at the healing site.
Diabetics, however, should be careful with substances that promote the release of growth hormone, and children with incomplete bone growth should also use such agents only under medical supervision. With diabetics, their condition could be either exacerbated or improved, and those with herpes and some psychotic conditions should also be careful.
Nitrogenous compounds are essential to life, and L-arginine plays a significant role in the storage, use and secretion of them. Without it life would not be possible, although it is its visible uses, such as the effect of nitrous oxide on blood flow and of proteins on muscle metabolism, for which it is best known to those that use it, either as a supplement or as a remedy. Pure supplement form is available at your local or internet health food store.
Green Coffee Bean Extract
October 22, 2008 04:59 PM
It is known that aging is largely a result of the effect of free radicals on our body cells, and that green coffee bean extract can be used to fight against these. While we intuitively understand what the term ‘aging’ means, very few people can actually describe it in words, although there are several theories of why it occurs.
The most viable of these include the Error Catastrophe Theory, related to faulty molecular transcription and errors in cellular function, the Crosslinkage Theory, in which progressively increasing cross-linking between proteins slows the body functions down, and the Neuroendocrine Theory, in which changes in homeostasis and hormone levels occur through time due to an increasing loss of sensitivity of receptors to feedback inhibition.
However, by far the most acceptable and best understood theory is the Free Radical Theory of Aging, which green coffee beans have been found to help fight, and it is on that which we shall focus here.
The Free Radical Theory of Aging
Free radicals are oxidants created by unpaired electrons. Electrons generally go around in pairs, but occasionally molecules lose one of these electrons, creating a situation where it possesses an unpaired electron. In this condition, that molecule has only one purpose in life and that is to oxidize other molecules by stealing an electron from them.
Oxidation can cause untold damage to cell membranes, and also to other molecules that are vital to life, such as DNA. The end result is aging, and the onset of many diseases and conditions connected with aging. Free radicals are believed to be behind inflammatory diseases such as arthritis and Crohn’s disease, strokes, cardiovascular disease, Parkinson’s disease, Alzheimer’s disease and cancer among many others. Each of these is associated with aging.
Free radicals are generated in the body in four different ways:
1. Energy is generated by the intercellular mitochondria by the production of ATP (adenosine triphosphate). By-products of the mechanism by which this is done include hydrogen peroxide, the superoxide anion, and a hydroxyl radical. Over 20 billion molecules of antioxidant are produced in each individual cell daily, and every one of these has the capability to do damage to your body. The figure for inefficient cell metabolism is significantly higher.
2. Peroxisomes are eukaryotic cell components that contain oxidative enzymes, whose function is to produce hydrogen peroxide that is then used by another enzyme, catalase, to oxidize other toxic substances. It is used by the liver, for example, to oxidize about a quarter of all the alcohol we drink to acetaldehyde, and also to remove other toxins from the body. The down side is that the hydrogen peroxide can escape and degrade the cell membranes.
3. Chronic infections give rise to a high activity of white blood cells, which utilize oxidants of various kinds to destroy viruses, bacteria and parasites. These include hydrogen peroxide, superoxide and Nitric oxide which can also destroy the cells they are protecting.
4. Cytochrome P450 is an enzyme used to clear the body of toxic chemicals in our food such as pesticides and drugs. They also give rise to oxidative by-products.
In addition to these, free radicals are also produced by air pollution consisting of smoking, factory emissions and traffic fumes. Trace metals such as lead, iron and copper, are rich free radical sources, as is the ultraviolet component of sunlight, and caffeine, from tea and coffee, can also contribute to the store of free radicals in your body.
So where does green coffee extract come into this, and how should it be used. Free radicals tend to react very rapidly to accelerate aging, and in order to counter them, and hold the effects of aging at bay, it is necessary to destroy them almost as quickly as they are produced. This is carried out by antioxidants, of which there must be a plentiful supply available in each body cell.
Antioxidants donate electrons to free radicals, and so effectively neutralize them before they can attack the membranes of the cells in your body, or any of the other tissues that they can degrade. Many of the vitamins have a powerful antioxidant effect, among them vitamins A, C and E. Other antioxidants available in our diet include beta carotene and other carotenoids, flavonoids and glutathione, and also cofactors such as lipoic acid. All of these can destroy free radicals by the donation of an electron.
Green coffee beans have also been found to possess a strong antioxidant effect, due largely to the plant phenols, such as caffeic acid that forms chlorogenic acid with quinic acid, both cholorgenic and caffeic acid being string antioxidants. Green coffee bean extract is standardized to 99% chlorogenic acid. This substances not only reacts rapidly with free oxygen radicals but also helps to prevent to formation of hydroxyl radicals.
It has been established that green coffee bean reacts twice as fast as green tea or grape seed extracts, and speed of reaction is critical in the destruction of free radicals that have to be destroyed before they do damage. Other antioxidants found in extracts of green coffee beans include heterocyclic compounds such as pyrroles, furans and maltol.
The extract is made from beans of Coffea Arabica, this containing higher concentrations of chlorogenic and caffeic acids than the Arabica plant. The extract is also produced to be naturally low in caffeine, thus avoiding the negative effects of drinking coffee for its stimulating properties. When the green coffee bean is roasted, the antioxidant effect is found to decrease, and after roasting and brewing both the Arabica and the Robusta beans have reduced in activity to much the same level.
Studies on some of the conditions exacerbated by free radicals have indicated the effectiveness of green coffee beans as an antioxidant. It is believed to help reduce atherosclerosis caused by the oxidation of low density lipids (LDL). Oxidized LDLs tend to be easily absorbed by phagocytes to form plaques and foam cells in artery walls, thus narrowing and hardening the arteries, causing a deprivation of oxygen and nutrients to the heart and also increased blood pressure. Antioxidants from the green coffee bean prevent this from happening, and so help to reduce this serious effect of aging.
A good supply of antioxidants will also prevent the cell membranes from being destroyed, one effect of which is to age the skin. Antioxidants in the form of green coffee bean extract can help to maintain a youthful appearance while also aiding in the prevention of the more serious effects of free radicals that can shorten life.
There are no doubts that free radicals contribute significantly to accelerated aging, and that the antioxidants contained in green coffee beans can help hold back the physical signs of aging, while also helping to destroy those free radicals that threaten life by promoting cancer, atherosclerosis, and other similar conditions.
Pine Bark Extract Boosts Nitric Oxide Production
January 17, 2008 03:24 PM
A recent study has found that Pycnogenol, which is an antioxidant plant extract from the bark of the French maritime pine tree, helps individuals by enhancing the production of Nitric oxide (NO), which in turn leads to an increase in blood flow and oxygen supply to muscles. Nitric oxide is a key cardiovascular chemical that is produced by the body. It increases blood flow which allows more nutrients and oxygen to be delivered to the muscles. This helps muscles to cope with increased physical activity. The study also suggests that taking Pycnogenol provides more NO in response to neurotransmitters which allows for better expansion of arteries, which can then carry more blood. This process meets the enhanced oxygen demand of muscles and helps to avoid anaerobic metabolism. The results of this study also lead researchers to believe that Pycnogenol can be a natural alternative therapy in diseases involving oxidative stress.
The study was held at the Hiroshima University Graduate School of Bio-medical Sciences in Japan. Each day for two weeks, healthy, young men were given either 180 mg of Pycnogenol or a placebo. In order to identify Pycnogenol's effect on the release of Nitric oxide, patients were infused with an inhibitor of L-arginine, which restricts arteries from expanding in response to the neurotransmitter acytelcholine. After two weeks of supplementation, the results revealed that blood flow had increased by forty two percent. Additionally, the group receiving a placebo did not show a significant blood flow increase at all. NO causes the muscle surrounding the arteries to relax, resulting in an increase in the diameter of the blood vessel, while acetylcholine stimulates the cells of arteries to produce NO from L-arginine faster. When the subjects being tested had taken Pycnogenol, the arteries relaxed and blood flow increased by Fourty two percent, as compared to the placebo group.
Although more research is warranted, this breakthrough is especially encouraging to athletes since Pycnogenol seems to allow people to move faster when they are exercising. It does this by satisfying the enhanced muscle oxygen demand and also increases the blood flow to the active muscles. People who are performing heavy physical activity experience the release of acetylcholine by nerves to arteries that are supplying the active muscles. This acetylcholine makes them expand, while the whole process requires that there is an enhanced production of Nitric oxide.
A great variety of studies about Pycnogenol and sports nutrition have been conducted over the past years. The most recent one occurred a year ago. In this study, Pycnogenol was found to improve blood circulation even in extended aerobic muscle activity. Pycnogenol also enhanced sports endurance be alleviating the cramping and muscular pain that occurs in the majority of athletes. To sum it up, Pycnogenol is not only effective for enhancing and prolonging the performance of muscles during support, but it also supports muscle adaptation to a higher workload and allows the body to recover from physical faster.
When shopping for a good pycnogenol supplement, look for a standardized extract that guarantees that each capsule or tablet contains a specific amount of active ingredients per serving, otherwise you might be purchasing something that is ineffective.
Tongkat Ali: The Natural Viagra?
October 22, 2007 10:02 AM
Tongkat Ali is also known as Longjack, and is a well known aphrodisiac in South East Asia, the root of which has been found effective both as an aphrodisiac and in treating certain sexual problems including failure to achieve an erection. What Viagra does in the west, Longjack does in the east, only cheaper.
The tree is also called Pasak Bumi, and had originally been used for many years as a treatment for malaria, the side effects being accepted but not understood as originating from the malaria medication. Some though that the malaria itself perhaps caused them, and was a long time before the effect of tongkat ali on the testosterone levels in the body was understood.
The name literally means Ali’s walking stick, and is named after the long roots from which it is extracted. The tree itself is about ten metres high, and grows beneath the canopy of the Indonesian rainforests. However, due to a heavy demand for the product, the older trees are increasingly more difficult to find, and most of the herbal preparation is extracted from younger trees. The tree itself is not easy to cultivate outside its natural environment, and is very slow growing.
Unlike many herbal remedies used in Asia, the effects of Tongkat Ali on the libido have been supported by scientific medical evidence, and it has been demonstrated to support the availability of unbound testosterone and to support hormonal balance in general. It had been used for many years to promote sexual desire and sexual ability before the medical evidence was obtained to provide scientific support to what was already known by the indigenous population: that it was effective in improving sexual ability, stamina, and endurance and to reduce mental fatigue in general.
Although it was originally used as a treatment for malaria, Longjack increases the natural production of testosterone in the body and hence improving the male sex drive and also that of women. It is a little known fact that women, too, need testosterone for their sexual impulses. However, it is probably more important from a physiological point of view that testosterone is essential to women in that it increases the metabolic rate and accelerates the burning and elimination of fats, and the production of red blood cells and the development of muscle tissue.
As the production of testosterone drops off with age, generally starting after about thirty years, bodybuilders find it increasingly more difficult to maintain a good body shape and muscle shape. They are interested in anything that could feasible maintain or even increase the production of testosterone by the body, and Tongkat Ali does this. To them, the increase in their libido, or sex drive, is a bonus that they will not refuse to take advantage of!
Eurycoma longifolia, the scientific name for the tree, increases the amount of adenosine triphosphate (ATP) in the body. ATP, along with its cousin adenosine diphosphate (ADP), is responsible for the availability of energy for use by the body. It is normally created from ADP and glucose, and an increased availability in the blood can reduce the fatigue caused by its consumption through vigorous exercise. However, if too much ATP is available, the subject can suffer from insomnia and restlessness since there is too much ATP in the body.
The function of the ATP is to provide available energy that can be used by the muscles in exercise. When energy is used up the ATP is converted to ADP, which needs more glucose to reform the ATP. If there is excess ATP, it is like a charged battery within the body, and we become restless until the energy available is used up.
Another benefit of this amazing substance is that it helps the body to increase its own production of sex hormones, rather than simply provide them for it. People who suffer from sexual dysfunction conditions tend to be provided with HRT (Hormone Replacement Therapy) from their physicians or doctors which involve the introduction of testosterone intravenously. The result of this is that your body recognizes that it has a sufficient supply of testosterone and so stops making it for itself. Eventually your body just stops testosterone production, and relies on the artificial supply it has got used to receiving. Longjack treatment, however, does not provide a supply of testosterone, but stimulates your body to produce its own, which is better for it in the long run.
You should, however, be made aware of the possible side effects or testosterone administration which are insomnia, anxiety and a possible reduction in your immune functions. There are also other possible side effects if you suffer from diabetes, or heart liver or kidney disease, and you should always refer to your doctor before commencing its use. If you start off your treatment with small doses and check out the side effects at each stage, then you will be able to safely find out if these side effects relate to you. If not, then you are all set as long as you obey the advice of your physician.
Another natural product that is recommended as an aphrodisiac is Horny Goat Weed, but when used in combination with Tongkat Ali it appears to have a synergistic effect. Horny Goat Weed is also called Fairy Wings and a number of other alternatives names, and is not one but about 60 different flowering plants found in southern China. It works by increasing the Nitric oxide concentration in the body that helps to relax the smooth muscles.
By itself Horny Goat Weed is an effective aphrodisiac, but the combination of its effect in relaxing the penile muscles and the increased testosterone levels promoted by Longjack is extremely powerful, and much more effective in resolve sexual problems in men that either of them alone.
For this reason tongkat ali is frequently sold in combination with horny goat weed. Although not unusual, it is not common to find natural herbs that have such a profound effect on the libido and whose effect is backed up by scientific evidence. Tongkat ali is one of those, and although it is still currently mainly used in Asia, demand for it in the west is rising.
Complete Liver Cleanse
April 19, 2007 04:17 PM
Complete Liver Cleanse
Technical Data Sheet
The liver performs over 500 functions, including metabolizing carbohydrates and proteins, synthesizing and storing vitamins, and regulating hormones – naming just a few. To do this job, the liver is also required to be exposed to potentially harmful toxins and chemicals, every day.
One way to support the liver is through periodic supplementation with the proper balance of herbal ingredients, phytosterols, and fiber. Complete Liver Cleanse is a convenient, multi-ingredient formula that supports overall liver health and detoxification.
Complete Liver Cleanse:
Includes ingredients for various aspects of liver and gallbladder support:
-Herbal ingredients that support liver and gallbladder health
-Detoxifying ingredients that keep bound toxins from being reabsorbed
-Phytosterols to block cholesterol absorption in the intestines
-Fiber that moves cholesterol and toxins out of the body
-Oat beta-glucan fiber with up to 4 times higher viscosity than other beta-glucan
-Simple, two week liver cleanse program
Each 3 capsules contain:
Calcium (as calcium D-glucarate) 13 mg
Proprietary PuraFiber Blend: 1 mg
Viscofiber Oat B-Gucan Concentrate, phytosterols
(beta sitosterol, campesterol, stigmasterol, brassicasterol,
and other plant sterols), and glucomannan
Milk Thistle (Silybum marianum) Fruit Phytosome 220 mg
One part Milk Thistle Extract, standardized to contain 80%
Silymarin bound to two parts phosphatidylcholine (soy) using
a patented process
Burdock (Arctium lappa) Root Extract 4:1 100 mg
Calcium D-Glucarate 100 mg
Boldo (Peumus boldus) Leaf Extract 2:1 75 mg
Turmeric (Curcuma longa) Rhizome Extract 50 mg
Standardized to contain 90% curcuminoids
Dandelion (Taraxacum offinale) Root Extract 4:1 50 mg
Artichoke (Cynara scolymus) Leaf Extract 30 mg
Standardized to contain 13-18% caffeylquinic
Acids calculated as chlorogenic acid
Contains no: sugar, salt, yeast, wheat, dairy products, artificial coloring, artificial flavoring, ingredients of animal origin, or preservatives. This product contains natural ingredients; color variations are normal.
Other ingredients: See label for most current information
Viscofiber is a registered trademark of Cebena Bioproducts, Inc. The use and composition of the Viscofiber proprietary formula is protected by patients and patent applications filed in the
This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, LLC, and protected by
HOW DOES IT WORK?
Every day, the liver must process an almost unbelievable amount of blood – at a rate of three pints every minute. All the while, the liver performs over 500 physiologic functions, including protein and glucose synthesis, carbohydrate metabolism, vitamin and mineral storage, synthesis of clotting factors, urea formation, metabolism of medications, and the production of bile. The liver also assists in hormonal regulation, blood glucose control, and other regulatory functions.
Harmful substances that have been neutralized by the liver are carried to the intestines and kidneys for excretion. They are transported by bile, a greenish, watery solution that is synthesized, and continuously being excreted, by the liver. Stored in the gallbladder, a small sac cupped in the under surface of the liver, bile is also required for the digestion of dietary fats. However, in the case of toxins, bile is primarily an early transporter of the toxic compounds to the intestines, where they can be bound to fiber that helps transport them out of the body. Environmental toxins, including lipid (fat) soluble toxins, are broken into water-soluble components by bile to be excreted through the kidneys or colon.
Detoxification refers to the process of excreting potentially harmful compounds that are both generated by the body and acquired through exposure to the environment. In the body, toxins are generated as by-products of cellular metabolic processes. Examples include dead and digested bacteria, hydrogen peroxide, cellular debris, and carbon dioxide.
The Environmental Protection Agency has determined that the amount of environmental toxins in the air, groundwater, and soil has increased significantly in the last 40 years. In fact, the use of pesticides has doubled every ten years since 1945. Americans are increasingly exposed to heavy metals, pesticides, fossil fuel emissions, sulfur oxides, hydrocarbons, and other harmful chemicals. The Environmental Protection Agency reports that traces of toxic chemicals can now be found in nearly every American.
Herbal Liver Support
One of the major components in Complete Liver Cleanse is its milk thistle extract, standardized to contain 80% silymarin, the plant’s most bioactive compound. Milk Thistle provides support, at a cellular level, for healthy liver function. A patented delivery system, known as the Phytosome process, provides superior absorption of the milk thistle extract.
Silymarin, a key compound found in milk thistle, is a mixture of flavonoids with a long history of liver support. Silymarin supports the health of Kupffer cells, specialized liver cells responsible for removing bacteria, old blood cells, and other foreign matter from the liver’s blood supply. Silymarin scavenges free radicals (superoxide anion radical and Nitric oxide) produced by activated Kupffer cells, supports healthy leukotriene levels, and supports glutathione production that is used in detoxification.
Silymarin also supports the health of hepatocytes, highly versatile liver cells with unique physiologic functions. Studies of silymarin have demonstrated that it supports the health of the hepatocyte outer membrane, which is crucial to the liver’s detoxification processes. Silymarin also supports the healthy regenerative ability of the liver through support of protein synthesis in the hepatocytes.
A special, patented proves known as Phytosome enhances the absorption of milk thistle in Complete Liver Cleanse. The Phytosome process pairs herbal ingredients with phosphatidylcholine molecules. Phosphatidylcholine is a naturally occurring substance found in soybeans, egg yolks, and some vegetables. In the body, phosphatidylcholine is an important building block of cell membranes.
When milk thistle (or other herbs) are bound with phosphatidylcholine, the phosphatidylcholine molecule facilitates absorption through the intestines into the bloodstream. Research has shown increased blood and serum levels for phytosome herbs in comparison to the individual herb alone.
To test whether binding an herb with phosphatidylcholine increased its bioavailability, researchers gave volunteers identical amounts of either milk thistle alone, or milk thistle phytosome. The researchers then took blood sample from the participants and measured the level of silybin (a key compound in milk thistle). The measurements showed that silybin levels in participants taking the phytosome form of milk thistle were higher, and that silybin was detected for a longer time, than those who took milk thistle without the phytosome delivery system.
Other Herbal Liver Supportive Ingredients
Herbal extracts are often at their best when they are working synergistically – that is, when different constituents of each plant work together and support each other. Complete Liver Cleanse contains a variety of herbal extracts that have noted benefits for supporting the body’s healthy bile flow and free-radical scavenging effects. These ingredients provide a wide spectrum of liver supportive benefits.
For instance, dandelion root extract supports healthy bile flow from the gallbladder.
Burdock is originally native to Europe and Asia, but was introduced to
Burdock root (Arctium lappa) supports the natural physiologic processes of organs involved in detoxification and elimination: notably, the liver, kidneys, and intestines.
Bolodo (pemus boldus) is a small evergreen native to South America, but naturalized to southern
In scientific studies, boldo appears to have strong free-radical scavenging ability, mostly attributed to the catechin and flavonoids content of its leaves. In a clinical study, boldo also appears to relax smooth muscle and support intestinal transit time.
Artichoke Leaf extract specifically supports healthy bile production in the liver and healthy gastrointestinal function in general. Research into artichoke’s gastrointestinal supportive properties has included at least three clinical trials. Artichoke’s role in supporting healthy cholesterol levels within normal limits has also been investigated.
Turmeric (Curcuma longa) is a perennial shrub native to southern
More recently, turmeric has been investigated for its support of healthy bile secretion, and pancreatic and gastric function.
In a scientific study, dietary curcuminoids derived from turmeric supported healthy lipid metabolism and cholesterol levels already within normal limits.
Curcumin has also been shown in scientific studies to enhance the activity of glutathione S-transferase - an enzyme responsible for linking glutathione (one of the body’s natural antioxidants) with toxins to help remove them from the body. In this way, it provides additional support for healthy liver function.
The process of detoxification is the breakdown and excretion of substances that are no longer needed or may be harmful to the body. One of the ways in which the body excretes hormones and toxins is by binding them to glucuronic acid in the liver, and then excreting this compound in the bile.
However, this process can be disrupted by B-glucuronidase, an enzyme that is produced by intestinal bacteria. This enzyme has the ability to break (uncouple) the chemical bond established by glucuronic acid. This action releases the bound toxins, which are then reabsorbed into the body instead of being excreted.
Calcium D-Glucarate is the calcium salt of d-glucaric acid. It is found in both the human body, and in some plant sources, including broccoli and oranges.
Calcium d0glucarate enhances the body’s detoxification systems by inhibiting the actions of beta-glucuronidase. This helps decrease the portion of active compounds that could be hazardous to the body.
Cholesterol is a waxy, fat-like substance that is vital to fat digestion, cell structure, nerve insulation and hormone production. Cholesterol comes from two sources: dietary or “exogenous” cholesterol absorbed in the intestine, and “endogenous” cholesterol formed mostly by the liver and stored in the gallbladder.
Cholesterol occurs in two forms known as lipoproteins. Lipoproteins act as transports that carry fat s to and from the cells.
High-density lipoprotein (HDL) carries low lipid density cholesterol (LDL) away from arterial walls and returns it to the bloodstream. LDL then travels back to the liver, which processes and eliminates it. While high levels of HDL cholesterol is desirable, high amounts of LDL cholesterol is not supportive of optimal health.
LDL-cholesterol is both synthesized in the body, or absorbed into the bloodstream through receptor sites in the intestines. Think of these receptors as “parking spaces” for cholesterol. As it happens, the liver can receive up to 500 mg per day of cholesterol from intestinal absorption. (It can also produce as much as 1000 mg per day).
One way to help reduce the absorption of LDL cholesterol molecules it to occupy their “parking places” in the intestines. Phytosterols in Liver Cleanse are essentially the “fat” of plants. They’re found in nuts, corn and rice and are some of the “good” fats associated with the benefits of olive oil, flaxseed oil and other healthy oils.
The structure of phytosterols is so similar to cholesterol that they fit perfectly in the specially-shaped intestinal parking spaces that LDL-cholesterol would normally occupy.
Taken with, or just before meals, phytosterols block the cholesterol receptor sites so that cholesterol is excreted from the body rather than absorbed. Phytosterols also have the additional role of helping promote healthy bile salt excretion in the intestines.
The phytosterol blend in Complete Liver Cleanse can help minimize the absorption of cholesterol from high-protein food sources, help retain healthy cholesterol levels that are within normal limits, and move bile sat through the digestive system.
Fiber and detoxification
Fiber plays a key role in the removal and excretion of intestinal toxins in detoxification. Only fibers that can effectively bind toxins will be successful in eliminating these harmful substances. Due to the unique benefits of individual fibers, the best binding, removal, and elimination effects are noted when combining different fiber types. Complete Liver Cleanse contains a combination of oat beta-glucan and konjac fiber that has been shown in scientific studies to bind to bile salts.
Dietary fibers are complex mixtures of cellulose, hemicellulose, pectin, mucilage, and gums, which are resistant to digestive fluids or enzymes – that is, they aren’t absorbed into the bloodstream. So, while fiber itself doesn’t necessarily provide nutrients, it does promote laxation and modulate gastric and intestinal physiology. Intestinal flora that normally reside within the colon utilize fiber as a medium for microbial fermentation, resulting in the synthesis of the vitamins, vitamin K and biotin, and the formation of short chain fatty acids, or SCFA.
SCFA have a simple, but important job: to be absorbed by the colon mucosa, increasing fecal matter bulk and providing energy. Fiber has been demonstrated in numerous clinical studies to provide support of gastrointestinal, cardiovascular, immune, and endocrine function health.
Complete Liver Cleanse also features two unique fibers to promote detoxification – konjac and oat beta-glucan.
Konjac, (Amorphophallus Konjac) is a tuber native to
As a fiber, konjac has shown positive results maintaining healthy cholesterol levels within normal limits in clinical studies. This beneficial effect is due to konjac’s ability to boost excretion of bile acid.
Oat beta-glucan has been a widely studied fiber source for supporting healthy cholesterol levels within normal limits.
In a randomized clinical study, oat beta-glucan showed support of healthy HDL/LDL ratios already within normal limits in individuals over a three week trial.
Closely linked to cholesterol, oat beta-glucan has also been studied for its support of healthy bile excretion.
Fiber has benefits beyond maintaining healthy cholesterol levels already within normal limits. It also contributes to healthy blood sugar levels already within normal limits. In a double-blind, clinical study, the oat beta-glucan fiber used in Liver Cleanse was shown to have 4 times higher viscosity than another high concentrate beta-glucan fiber.
Viscosity – the resistance to flow – is an important factor in beta-glucan, and all fiber. Water, for instance, would have a low viscosity, because it provides very little resistance to movement. Fiber, on the other hand, should have a higher viscosity in order to maximize its transit time through the GI tract, providing a gentle “scrubbing” on the intestinal walls. Therefore, the higher the viscosity, the greater the potential benefit.
Three capsules in the morning and three capsules at bedtime for 14 days.
Warnings: Do not use if you know or suspect you have an obstructed bile duct or problematic gallstones. If pregnant, nursing or taking prescription drugs, consult your healthcare practitioner prior to use. Keep out of reach of children.
Supplements for Sexual health!
April 17, 2007 02:35 PM
Improving Sexual Performance Naturally
Sex. It’s everywhere. It’s on TV (a lot!). It’s in the books we read and the movies we watch. Even the radio seems a veritable hot bed of sex. (what would hard rock, soft jazz, or Motown classics be without songs about sex?) Magazines are full of sex and it’s not just the “naughty” ones with glossy centerfolds. From Sports Illustrated to Good Housekeeping, sex makes for titillating headlines and cover stories. In fact, 21st Century
No one really knows for sure how many of the 113 million married Americans are living as couples with DINS (dual income, no sex). Estimates range from 15 to 50 percent. Even couples who have sex fairly often feel like they’re not having enough sex or that it’s not as enjoyable as it was in the past, or both. And while women are stereotyped as the sex refusers and avoiders, surveys show that both women and men decline spousal advances fairly equally.
What’s really interesting about this lack of sexual activity in
As a medicine hunter, I have discovered effective plants and herbs al over the planet that really do improve orgasms in women and erections in men. Now it’s your turn. I’m going to teach you how to enhance your sexuality and introduce you to an entire arsenal of libido lifting plants to help make sex fun, vibrant, and satisfying for both you and your partner.
Q. These plants sound too good to be true. Do they really work?
A. Yes, they do. Part of their success is their ability to work with your body’s innate mechanisms for healthy sex. Good sex is much more than just stimulated body parts. But it’s a good place to start!
A man needs an erect penis that remains firm past foreplay and on into intercourse. He also needs to sustain that erection and experience forceful and pleasurable ejaculation when he and his partner are both ready for his orgasm. A woman needs to feel desire and feel desired for her nipples to be aroused, her clitoris stimulated, and her vagina lubricated – the basics leading to her orgasm.
Plants that enhance sex can help men and women obtain these bare necessities of sex. And unlike other supplements, you’ll know if the medicinal plant you’ve purchased is actually doing what it promised to do. You can’t really tell if the calcium supplement you take each day is making your bones stronger. But you will be able to tell pretty soon if Catuaba, for example, is increasing your sexual desire.
Q. Night after night, my husband falls asleep on the sofa. And the honest to goodness truth is that I’m too tired for sex, too. I love my husband and once upon a time I loved sex. But my job, the kids, those never-ending errands, and trying to keep up with the laundry are too exhausting. Is there a plant that can rev us up?
A. Many women are in the same sexless boat you’re sailing around in and they don’t like it any more than you do. In fact, women all over the world put their family’s needs before their own, leading to some very tired moms and wives.
Life’s demands can also impair sexual performance in men. Work stressors, family demands, and home maintenance result in fatigue and lack of energy. Men find that they have no energy left to devote to to sex at the end of the day.
But, over 80 percent of married couples in the world have at their disposal a health care system that integrates sex into their personal health and well being. For centuries, millennia actually, practitioners of traditional medicine have prescribed Maca and Rhodiola to reduce “sexual fatigue” in women and men who are just too tired to make love.
Q. Since I had a baby four months ago, I have no desire for sex. This is making my husband pretty frustrated and me too, actually. I’d love to want sex again.
A. A married woman with a baby and a toddler or two can feel that her body isn’t really hers. So much for feeling sexy! While this fact can be a source of great pride and joy, it can also drain desire.
As women enter perimenopause – those years when they are still menstruating despite fluctuating estrogen levels – they often have no desire for sex. Since estrogen is the engine that drives women’s reproductive function, when it starts to go, sex goes too. Women who have reached menopause may find their minds wandering during sex. Pondering the car’s need for an oil change or if the milk in the refrigerator has reached its expiration date makes for pretty blah sex. It also makes it nearly impossible to achieve orgasm.
Once more, traditional medicine has some answers:
Q. My husband has a desire for sex, but sometimes it’s not enough. Even if we’re both in the mood, he can’t maintain his erection very long. It’s very frustrating for us both.
A. For men it’s often their equipment that lets them down. As men age, they find they can’t get an erection hard enough or keep an erection long enough to satisfy their partners and themselves.
While women can fake an orgasm if they’re tired, men have to perform every single time they have sex. Luckily, Mother Nature can help:
Q. There are hundreds of supplements that claim to make men hard and women weak with desire. I’ve tried some of these, and they don’t do anything. When should I believe that the herbs and plan medicines you have discovered are nay better?
A. There are a lot of “snake oil” companies out there pitching products that promise to improve our sex lives but do absolutely nothing. One reason for this glut of useless supplements is simple demand. Men and women trying to make their sex lives better, are willing to give most products the benefit of the doubt and buy one or two. Sex sells – and even products that are purchased one time only will make big profits.
To get the most for your money, make sure the sexual supplement you are considering is from a well-respected manufacturer. Ask store staff, surf the Internet, and do some searching for the best nutraceutical companies. Make sure the herbs are standardized and that the extracts are concentrated fro optimal benefit.
Q. Are these sex-enhancing plants safe?
A. Despite years of use by practitioners of traditional medicine, significant adverse effects have not been reported for most sex-enhancing plants. However, men who have already been diagnosed with certain health conditions such as high blood pressure, thyroid disease, prostate problems, or other illnesses should use caution when selecting any health supplement. The same advice applies to women, especially women who are pregnant or nursing. And always remember to keep your doctor informed about the supplements you are using, especially if you are also taking prescription drugs. But the sex-enhancing plants have been traveling on planet Earth for a long, long time. And hopefully they’ll be here for lot longer, continuing to work effectively and go about their business of safely improving orgasms and erections and making sex great for men and women all over the world.
Q. OK, exactly how did early native healers figure out which plants improve sex? Was it just simple trial and error?
A. It does seem pretty remarkable that tribal peoples have discovered the right plants to treat diseases and improve health without modern day scientific advances.
From my many years as a “medicine hunter” in rainforests and grasslands and marshes and mountains, I’ve learned that healing plants exist for virtually every health need. It’s up to the medicine man or women to put the plant into practice. These healers have been able to do this successfully for thousands of people, by intensively studying and working with the plants. By putting themselves into the plant’s world, becoming part of the world around them, native healers have intuitively discovered which plant helps which disease. It wasn’t mere luck that brought all those plants and all those healers together. It was the natural and spiritual connection existing between the two.
Q. Are there other “natural” remedies we can use to improve our sex lives?
A. The easiest way to naturally enhance your sex life is to practice, practice, practice! Because if you don’t use it, you might lose it. Studies have shown that couples in the Amazon rainforest as well as couples in the concrete jungle of New York City have better sex lives if thy make sex a priority. All the sex-enhancing plants in the world are useless if the men and women taking them don’t put them to the test.
Men who smoke need to quit. Research has shown that cigarettes send men’s sex lives up in smoke. Men who smoke more than 20 cigarettes daily have a 60 percent higher risk of erectile dysfunction compared to men who never smoked. That’s because smoking decreases blood flow making it difficult for men to obtain an erection.
And finally, since sex is a visual and tactile endeavor, there are quite natural and creative ways to give it a boost. Visually stimulating images can arouse even the tiredest of the tired. Premiere Magazine recently compiled a list of the most erotic movie sex scenes ever. You don’t have to feel embarrassed when renting these movies (as you might with pornography) at the video store and they are guaranteed to light up your life:
2. Hilary Swank pleasuring Chloe Sevigny in BOYS DON’T CRY (1999)
3. Brad Pitt and Claire Forlani making love in MEET JOE BLACK (1998)
4. Leonardo DiCaprio drawing Kate Winslet in the nude in TITANIC (1997)
5. Sharon Stone uncrossing her legs while she is being interrogated in a room full of en in BASIC INSTINCT (1992)
6. Patrick Swazye and Demi Moore in the pottery secene early on in GHOST (1990)
7. Michael Douglas and Glenn Close having sex in an elevator in FATAL A TTRACTION (1987)
8. Mickey Rourke caressing Kim Basinger’s body with an ice cube in 9 1.2 WEEKS (1986)
9. William Hurt and Kathleen Turner having sex in BODY HET (1981)
10. Julie Christine and Donald Sutherland making love in DON’T LOOK NOW (1973)
11. Rita Hayworth flipping back her hair and singing “Put The Blame on Mame” in FILDA (1946)
One Important Last Point
Sex always has consequences. And improving your sex life does not eliminate the requirement to practice it responsibly. Sexually transmitted diseases, hepatitis, and HIV/AIDS must be prevented, pregnancy must be considered and consent between partners must exist.
Sexual activity keeps us connected – both tangibly and spiritually to our heart’s desire. It helps us feel secure and well loved and adds to our self esteem. In other words, good sex is important to good life.
But all of us need a little help now and then. Sex-enhancing plants that have been used for thousands of years by millions of people provide that help. You can have actual sexual healing with effective sexual supplements and maybe find out what you’ve been missing.
After all, 80 percent of the world’s married couples can’t be wrong!
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.
Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.
To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.
Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.
Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.
Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.
In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."
In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:
• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.
• 78.9% of subjects showed an increased mean value of hair diameter.
• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."
Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.
Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:
• Total Number of Hairs: Significantly Increased
• Total Number of Terminal Hairs: Significantly Greater
• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher
• Hair Follicle Activation: Intensive
In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.
Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.
Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.
Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.
Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.
Spin traps modulate NF kappa-B regulated cytokines and inducible Nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and Nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.
Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.
If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.
The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.
After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.
Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.
MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.
Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.
The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.
According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.
The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.
Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.
Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.
L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.
Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.
In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.
Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.
Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.
After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.
This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Q. Is Revita safe ?
A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.
Q: Can I have my hair colored or permed while using Revita ?
A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.
Q: What is SLS/SLES free ?
A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.
Q: Can I blow dry my hair after using Revita ?
A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.
Q: Who is a candidate for Revita ?
A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.
Q: What type of results should I expect with Revita ?
A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.
Q. Does Revita have any systemic side effects ?
A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.
Q. Does Revita work for women?
A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.
Q. I am using other topical treatments. Can I use Revita at the same time ?
A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.
Q. Do I need to use Revita for a long time ?
A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.
Q: Is stress a factor in hair loss?
A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
l-Arginine/l-Citrulline Complex - Supports Peak Performance
March 06, 2007 02:24 PM
l-Arginine and l-Citrulline are two amino acids bundled into a single powerful supplement. Both are key intermediates in the Krebs urea cycle, where they participate in the detoxification of ammonia via the production of urea. In addition, any arginine not converted to urea enters general circulation where it is distributed to various tissues and metabolized for other uses such as protein synthesis. l-Arginine is probably best known for its role in cardiovascular health and the formation of Nitric oxide (NO). The formation of NO mediates smooth muscle relaxation in the blood vessel wall, and thus reduces the workload of the heart. Many nerve cells also use NO as a signaling molecule. Erectile function, for example, is mediated by the release of NO from the autonomic nerves in the penis. Also, l-Arginine is an important factor in muscle metabolism promoting energy during exercise and increased recovery after a workout.
1 tablet contains:
l-Arginine (as l-Arginine HCI) 750 mg
l-Citrulline 250 mg
Suggested Use: 1 tablet four times daily.
Benefits - Supports joint function and tissue health*
December 11, 2006 03:46 PM
To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.
Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3
Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3
Promotes optimal joint comfort, function and flexibility*
Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4
Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7
Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8
Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges Nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11
Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.
Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*
Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14
Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.
Sustained Release – For lasting joint comfort and convenient dosing
To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.
Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.
2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.
3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.
4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.
6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.
7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.
8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.
9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.
10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.
11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.
12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.
13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.
14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.
15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.
Pycnogenol: Heart, Blood Sugar and Cellular Health
November 03, 2006 12:16 PM
Pycnogenol (pronounced pic-nojen-all) is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France. Pycnogenol® consists of particularly bioactive flavonoid species and its purity is in strict accordance with the United States Pharmacopoeia. Pycnogenol® was initially developed 35 years ago in Europe. During the past years it evolved as one of the most thoroughly researched nutritional supplements, with over 200 studies published in peer-reviewed journals. Seventy of these studies were clinical with in total more than 4,000 patients. Pycnogenol® taken in dosages from 25mg to 300mg is well tolerated and Pycnogenol® was attributed “generally recognized as safe” (GRAS) by the FDA.
Pycnogenol® supports healthy capillaries
The “Career” of Pycnogenol® began in Europe, where it was first used to maintain vein and capillary health. Pycnogenol® has been shown to strengthen blood vessel walls, with 15 clinical trials showing fast relief from ankle and foot discomfort. A recent study with 200 passengers on long-haul flights showed that Pycnogenol® taken before departure and again during the flight supports foot comfort and healthy circulation. Travelers typically comment that with Pycnogenol® it is much easier to put shoes on again upon arrival. Clinicians in Germany discovered that Pycnogenol® also supports healthy capillaries in the eyes. Retinal capillaries may be affected by imbalanced blood sugar levels. In a multi-center field study with 1169 subjects Pycnogenol® supported healthy capillaries in the retina and improved visual acuity to some extent.
Pycnogenol® benefits the cardiovascular system
More detailed investigation of the interaction of Pycnogenol® with blood vessel walls at the University of Florida, Tampa led to an amazing discovery. Pycnogenol® stimulates an enzyme in blood vessel walls that is responsible for generating the most important vascular mediator, known as “Nitric oxide” (NO). NO triggers relaxation of the arteries and supports clear blood flow. Hence, NO is the body’s mediator for maintaining healthy blood pressure levels and circulation. NO plays such an important function for cardiovascular health that Dr. Louis Ignarro (UCLA) and his co-workers received the Nobel Prize for this discovery in 1987.
A number of factors, including aging, can interfere with the body’s efficient production of NO. Supplementation with Pycnogenol® for four weeks was shown to restore NO production and improve blood supply to the fingertips of elderly people in a Japanese study. Microscopic evaluation of blood vessel diameter at the root of fingernails showed an increased diameter of capillaries allowing better blood perfusion. Specific sensors applied to the legs showed increased oxygen and decreased carbon dioxide presence. Better blood, nutrient and oxygen supply with Pycnogenol® benefits everybody. Italian researchers were able to show that regular intake of Pycnogenol® helps defy muscle cramps and minor pain in athletes.
The relaxation of arteries has a favorable effect on blood pressure. In two clinical studies Pycnogenol® taken for at least eight weeks was found to significantly support normal blood pressure.
Pycnogenol® stimulated NO generation directly translates into clear blood flow. This was first demonstrated at the University of Arizona, Tucson in smokers. Pycnogenol® dose-dependently, starting at a single dose of 25mg, countered the typical effects of cigarette smoking on the blood. Also, Italian vascular specialists found that Pycnogenol® supported the circulation of individuals on flights between New York and London.
Pycnogenol® supports healthy blood sugar levels
Pycnogenol® can support normal glucose levels when taken as part of a healthy diet and lifestyle plan. A clinical investigation has confirmed the significant glucose-lowering effect of Pycnogenol®. It was noted that Pycnogenol® did not affect insulin levels. Pycnogenol® appears to facilitate previously insulin-resistant cells to uptake sugar from the blood stream by yet unknown mechanisms.
Pycnogenol® limits cellular irritation
Two clinical studies carried out in Germany this year with student volunteers demonstrated that Pycnogenol® has a potent effect in preventing cellular irritation. Pycnogenol® inhibits a molecular “main-switch” in immune cells that triggers the onset of cellular irritation in any part of the body. Moreover, Pycnogenol® was found to inhibit so-called COX enzymes, which are involved with minor pain-sensation related to cellular irritation.
Pycnogenol® sooths menstrual pain
Japanese gynecologists discovered in 1999 that regular supplementation with Pycnogenol® soothes the normal discomfort of menstrual pain, particularly during cramping. Another clinical investigation of 47 women in year 2004 confirmed the effect of Pycnogenol® in addressing menstrual pain. This year a double-blind, placebo-controlled, multi-center field study with 116 women again confirmed these results. Pycnogenol® is not suitable for on-demand relief during menstruation. The studies show that Pycnogenol® reached highest efficacy when taken regularly for months.
Pycnogenol® helps to support respiratory health
Challenges to normal respiratory function may result from incidents the immune system perceives as harmful. Pycnogenol® offers valuable help in supporting respiration due to its immune-modulating effect and its ability to limit cellular irritation. A study at the University of Arizona found that Pycnogenol® supports clear breathing and lowers mediators of cellular irritation in the blood stream. More recently, a placebo-controlled clinical study at the University of California, Loma Linda described how Pycnogenol® supported healthy respiration in 60 children aged 6-18 years. Pycnogenol® needs to be taken continuously for prolonged periods of time for maximum benefit to the respiratory system.
Pycnogenol® is investigated in clinical trials all over the world. New findings are posted on the website www.pycnogenol.com.
Frank Schonlau Ph.D. is a biochemist who has spent nine years in medical research at the University Clinic of Munster Germany. His area of expertise covers vascular disorders, inflammation and dermatology. He has published more than 20 studies and review articles in the medical literature. Since entering the dietary field in 1999 he was involved in numerous studies on Pycnogenol® and communication of new health discoveries.
L-Citrulline 500mg capsules of powder
September 01, 2006 01:03 PM
L-Citrulline 500mg capsules of powder
L-Citrulline is produced in the urea cycle when carbamoyl phosphate is converted to Citrulline in the ornithine carbamoyl transferase reaction. When endogenous supplies of ornithine carbamoyl transferase are insufficient, supplemental L-Citrulline has been shown to support ammonia incorporation and liver detoxification of ammonia.
Buy Citrulline at Vitanet
Lutein eases blocked blood flow to eyes
August 11, 2006 01:50 PM
A recent study supported by Kemin Food Asia and conducted at the College of Medicine, Catholic University of Korea suggested that lutein protects the retina from cellular damage caused by eye conditions, including diabetic retinopathy and age-related macular degeneration. The researchers injected rats with lutein prior to retinal ischemia, or reduced blood flow to the retina caused by obstruction of the blood vessels. Results showed the lutein inhibited retinal degeneration, which is marked by reduced expression levels of neuronal Nitric oxide synthase and Cyclo-oxygenase-2, or COX-2. In addition, the reduction of these proteins appeared to be dose-dependent, which would imply benefit from increased exposure to this carotenoid. According to the lead author of the study, “These results suggest that a lutein supplement may protect against ischemia mediated cell death in the retina."
This Amino Acid may help your heart… and your heart’s desire.
May 24, 2006 05:45 PM
Give all to love, obey thy heart,” cries the poet, and most of us have felt the link between our hearts and our passionate feelings. In the more reasoned language of science, what connects the heart with the heat of amore is blood flowing freely through relaxed, wide-open arteries.
That’s where Arginine comes in. This amino acid (protein building block) has stirred excitement because of its ability to improve blood flow. Scientists now think that one reason nuts promote heart health, in addition to their high omega-3 content, is because they provide plenty of Arginine (as do other high-protein foods such as meat, cheese and eggs), and supplemental Arginine has been linked to improvements in cardiovascular function. This nutrient is also under the microscope as a way to promote healthy sexual functioning in both men and women.
As often as we’ve heart the heart described as a pump and the blood vessels as pipes, the plumbing analogy doesn’t entirely hold. For one thing, arteries—those vessels that carry oxygen and nutrient rich blood from the heart to the body are dynamic creations, with muscular walls that can narrow or widen as needed. One of the chemicals that control this process is called Nitric oxide, and Arginine plays a crucial role in Nitric oxide production.
Because the body can create its own stores, Arginine is classified as a non-essential amino-acid. However, scientists now think that getting a supplemental supply (in the form of L-Arginine) may be best for optimal well-being. In a well-designed multinational study, for example, men with high cholesterol who took l-Arginine experienced drops in both blood pressure and homocysteine, a substance associated with heart attack and stroke (Journal of nutrition 2/05). And a research team at UCLA believes that combining l-Arginine with such antioxidants as vitamin C and E may reduce inflammation that can lead to blocked coronary blood vessels.
Arginine’s ability to stimulate bountiful blood flow supports enhanced intimacy, which is both genders depends on a fully activated circulatory system. In fact, Arginine’s effects on Nitric oxide are similar to those of Viagra and comparable drugs except that Arginine “is much less dangerous,” according to nationally noted herbalist Ellen Kamhi.
Men and women experiencing sexual dysfunction enjoyed greater levels of satisfaction after taking an Arginine based supplement, and the ladies reported having better relationships with their partners. What’s more, Arginine has helped infertile men by making sperm stronger and healthier.
Arginine may also help keep things pumping smoothly as the gym. It promotes the release of human growth hormone, which helps muscles grow bigger, and boosts the production of creatine, which serves as a power pack for high-intensity sports. What’s more, Arginine helps the body rid itself of ammonia, a toxic byproduct of physical activity. The amino acid’s ability to enable protein creation aids not only athletes but also people recovering from wounds, including those associated with surgery and burns. (note: the herpes virus that causes cold sores thrives on Arginine; avoid supplements if your having an outbreak.)
When the mind is willing but the body falls short, let Arginine unleash your potential. –Lisa James, Energy Times.
HDL Booster - Boost your good cholesterol
March 16, 2006 12:51 PM
(Product No. 02922)
HDL Booster is a physician-developed dietary supplement that has been clinically shown to increase good cholesterol levels, particularly HDL-2, the best form of cholesterol.* The formula combines essential vitamins and minerals, at levels recommended by the American Heart Association (AHA), with key amino acids, powerful antioxidants, and traditional herbal extracts to provide superior support for cardiovascular health.*
· Formulated by Dr. Dennis Goodman, Chief of Cardiology at
· Clinically studied to increase good cholesterol levels up to 23%*1
· All-inclusive formula; includes ingredients recommended in accordance with the American Heart Association
· Replaces the CoQ10 depleted by cholesterol lowering (statin) drugs.*2
HDL Booster has been clinically shown to increase HDL cholesterol levels.* HDL Booster also supports healthy cholesterol and healthy triglyceride levels already within the normal ranges.* By reducing C-reactive protein levels, HDL Booster helps support the body’s natural anti-inflammatory response.*
Two tablets (one serving) contain:
Vitamin C (ascorbic acid) 148 mg
Vitamin E (as natural mixed tocopherols) 35 IU
Niacin (as niacinamide) 21 mg
Vitamin B6 (as pyridoxine HCl) 3 mg
Folic Acid 301 mcg
Vitamin B12 (as cyanocobalamin) 20 mcg
Magnesium (from magnesium amino acid chelate) 10 mg
Selenium (as L-selenomethionine) 49 mcg
Proprietary Blend 388 mg
hawthorn (Crategus oxyacantha) berry extract,
taurine, garlic (Allium sativum) bulb, grape seed (Vitis
vinifera) extract, grape skin (Vitis vinifera) extract,
N-acetyl-L-cysteine, alpha-lipoic acid, soy (Glycine
max) isoflavones, tocotrienols
L-Arginine (as L-arginine HCl) 153 mg
L-Carnitine (as L-carnitine L-tartrate) 51 mg
Coenzyme Q10 (CoQ10)(ubiquinone 10) 25 mg
Policosanol 7 mg
Other ingredients: See label for most current information.
Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives. This product contains natural ingredients; color variations are normal.
Cholesterol, the soft, waxy substance present among the lipids (fats) in the bloodstream and in all cells, is important for wide variety of physiological functions. It is essential for the formation of cellular membranes, necessary for the production of bile salts, and also plays a role in the synthesis of certain hormones.3-5
Cholesterol is both produced by the body and obtained from food. Endogenous cholesterol is formed by human cells, particularly liver cells, whereas exogenous cholesterol is absorbed through the gastrointestinal tract from food.3,4
Because cholesterol can not be metabolized for energy, it must be removed from the body once it has served its function. The major route of removal is through the liver, where it is processed and subsequently excreted from the body.3,4
Types of Cholesterol
Cholesterol is lipophilic (“fat loving” or water insoluble) by nature. It can not be dissolved in the blood, and must, therefore, be transported by carriers known as lipoproteins. These carriers are classified by density, with LDL (low density lipoproteins) and HDL (high density lipoproteins) being the most common.4,5
LDL is often referred to as “bad” cholesterol. LDLs carry cholesterol throughout the body. Conversely, HDL, or “good” cholesterol, is responsible for carrying cholesterol away from the arteries to the liver where it is eventually processed and eliminated from the body.3,4,6
Scientific studies have shown that both types of cholesterol are important indicators of cardiovascular health. But recent research, focusing on the beneficial subtypes of HDL, has found that certain fractions of HDL may be more supportive of cardiovascular health than others. The two most notably supportive HDL fractions are HDL-2 and HDL-3.7
The smaller HDL-3 is synthesized by the liver and intestines. This form, which is known as “free cholesterol-rich” HDL, scavenges or “scoops up” free cholesterol. The cholesterol is then chemically altered by the addition of an ester group. When sufficient cholesterol is esterified, HDL-3 becomes HDL-2, which is therefore referred to as “cholesterol ester-rich” HDL. HDL-2 is larger in size and has been shown to be more cardiosupportive than HDL-3.*7
HOW IT WORKS:
HDL is known to possess antioxidant activity and to help balance the body’s natural anti-inflammatory response, both of which are important for cardiovascular health, but its most important function is the role it plays in cholesterol transport.6,8 High levels of HDL cholesterol are also associated with reduced platelet activity, another key indicator of arterial and venous health.9
Both HDL and LDL levels are important indicators of healthy cardiovascular function.* Therefore, supplements that increase the level of good cholesterol can profoundly impact heart health.* In 2002, an open label pilot study was conducted at
The following chart summarizes the benefits of each of the ingredients in HDL Booster:
Triphala Fact Sheet
December 08, 2005 04:09 PM
Triphala Fact SheetNeil E. Levin, CCN, DANLA 6/30/05
LIKELY USES: Antioxidant Colon Cleansing, Detoxifying, Digestive, Liver and bile health
KEY INGREDIENTS: Triphala 500 mg, in a combination of fruit powders and extracts
MAIN PRODUCT FEATURES: Triphala is a combination of three fruits (Harada, Amla, and Behada) that has been used in Ayurvedic herbalism for thousands of years. Triphala's historical use as a digestive cleanser and tonifier has been backed up with numerous modern scientific studies demonstrating the positive effects of its component herbs on the gastrointestinal tract. In addition, Triphala has been shown to be a potent antioxidant, protecting cells against the damaging effects of free radicals. May help to dispel worms. Mild-acting internal cleansing; supports liver and gastrointestinal function
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW offers the first - and only - Triphala supplement to combine the fruit powders (400 mg) with the extracts (100 mg) of the fruits (doses given per tablet, there are three tablets per serving). Authorities like Dr. Andrew Weil consider Triphala to be a superior bowel tonic, rather than a laxative, with its benefits increasing over time. Laxatives typically are habit-forming and do not enhance normal body elimination of wastes; this is not the case with (moderate doses of) Triphala. This formula is suitable for vegetarians and is offered in tablet form.
SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, every three tablets provide 1,200 mg. (1.2 gram) Triphala powder and 300 mg. (0.30 gram) Triphala extract. Both the powder and the extract provide the three fruits in equal ratios, by weight. Take one to three servings per day, between meals.
COMPLEMENTARY PRODUCTS: Fiber sources (psyllium, pectin, etc.), Detox Support, Plant Enzymes, Virgin Coconut Oil, Dr. Verghese Liver Formula, Bentonite Powder, Probiotics (GR-8 Dophilus, 4x6 Acidophilus, etc.), Electrolytes (minerals) CAUTIONS: none
PRODUCT SPECIFIC: Contraindicated during pregnancy and lactation; avoid during menstruation; not appropriate for the very young or very old or the convalescent.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems.
Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
REFERENCES: Abraham S, Kumar MS, Sehgal PK, Nitish S, Jayakumar ND. Evaluation of the inhibitory effect of triphala on PMN-type matrix metalloproteinase (MMP-9). J Periodontol. 2005 Apr;76(4):497-502. PMID: 15857087 Al-Rehaily AJ, Al-Howiriny TA, Al-sohaiani MO, Rafatullah S. (2002) Gastroprotective effects of 'Amla" Emblica officinalis on in vivo test models in rats. Phytomedicine 9(6):515-522.
Arora S, Kaur K, Kaur S. Indian medicinal plants as a reservoir of protective phytochemicals. Teratog Carcinog Mutagen. 2003;Suppl 1:295-300. PMID: 12616620 Jagetia GC, Baliga MS, Malagi KJ, Sethukumar Kamath M. The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine. 2002 Mar;9(2):99-108. PMID: 11995956 Jagetia GC, Malagi KJ, Baliga MS, Venkatesh P, Veruva RR (2003) Triphala, an Ayurvedic Rasayana Drug, Protects Mice Against Radiation-Induced Lethality by Free-Radical Scavenging. J Alt Complement Med 10(6):971-978. Jagetia GC, Rao Sk,, Baliga MS, Babu K (2004) The evaluation of Nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytother Res 18(7):561-565.
Kaur S, Michael H, Arora S, Harkonen PL, Kumar S. The in vitro cytotoxic and apoptotic activity of Triphala--an Indian herbal drug. J Ethnopharmacol. 2005 Feb 10;97(1):15-20. Epub 2004 Dec 25. PMID: 15652269 Kaur S, Arora S, Kaur K, Kumar S. The in vitro antimutagenic activity of Triphala--an Indian herbal drug. Food Chem Toxicol. 2002 Apr;40(4):527-34. PMID: 11893411 Sabu MC, Kuttan R (2002) Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol 81:155-160. Sairam K, Rao CV, Dora M, Babu K, Kumar V, Agrawal VK, Goel RK (2002) Antiulcerogenic effect of methanolic extract of Emblica Officinals: an experimental study. J Ethnopharmacol 82:1-9. Sandhya T, Lathika KM, Pandey BN, Mishra KP. Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug. Cancer Lett. 2005 May 14; [Epub ahead of print] PMID: 15899544 Tamhane MD, Thorat SP, Rege NN, Dahanukar SA (1997) Effect of oral administration of Terminalia chebula on gastric emptying: an Experimental study. J Postgrad Med 43(1):12-13. Vani T, Rajani M, Sarkar S, and Shishoo CJ. Antioxidant Properties of the Ayurvedic Formulation Triphala and its Constituents. International Journal of Pharmacognosy Vol 35, No. 5, 1997:313-3
Curcumin - Turmeric Extract
August 19, 2005 12:47 PM
Turmeric- History and Traditional Usage
Native to Southeast Asia, Curcuma longa is a tall
In addition to its
Turmeric is named in
Protects cells and tissues by fighting free radicals.*
Supports joint function*
The numerous beneficial
Animal studies- In vivo protective effects
Through its free radical scavenging
Curcumin exhibits free-radical scavenging ability when
Bioperine-Nature’s Absorption Enhancer
Traditional Ayurvedic herbal
Curcumin is poorly absorbed in the intestinal
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Gamma E 400 Complex - Vitamin E with Powerful Tocotrienols
June 29, 2005 10:50 AM
Source Naturals brings you a better way of life with breakthrough research in vitamin E, the second most-recommended daily supplement today after multivitamins. No doubt you’ve heard how important vitamin E is to your health, but did you know that all vitamin E supplements are not alike? The bottle many people grab is usually a type of vitamin E chemically known as d-alpha tocopherol. Yet vitamin E is actually a general name for a whole family of compounds—and gamma E is gaining attention as a highly significant and potent form. Only Source Naturals GAMMA E 400 COMPLEX contains all four natural tocopherol forms, supplying 400 mg of gamma E tocopherol, 200 IU of alpha tocopherol, plus 5 mg of all four tocotrienols. And it takes the whole family together as they naturally occur, to derive the synergistic benefits of this remarkable vitamin.
Vitamin E refers to eight related, lipidsoluble antioxidant compounds widely distributed in plants and especially in vegetable oils: the tocopherol sub-family (alpha-, beta-, gamma- and delta-) and tocotrienol sub-family (alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol and delta-tocotrienol). These vital antioxidants are effective against free radicals inside the cell because they are fat-soluble and can pass through the lipid layer of the cell membrane. The American diet is naturally high in gamma E tocopherol compared to alpha—and research now indicates there may be a good reason for this.
The Missing Link?
Since alpha tocopherol has historically been the major form sold, gamma tocopherol received little attention. But new research demonstrates that gamma-tocopherol may be the missing link to advanced cardiovascular protection. The combination of vitamin E tocopherols— particularly those with a high gamma-toalpha ratio—is a more potent antioxidant than alpha-tocopherol alone. Gamma-tocopherol protects against peroxynitrite free radicals and lipid peroxidative damage. Research has shown that gamma can inhibit cyclooxygenase (COX-2) activity, the production of irritating prostaglandin E2, and protect against nitrogen-based free radicals as well as afford improved cardiovascular support. Gamma has also been shown to support the activity of the alpha form as well as offer activity of its own—gamma supplementation results in an increase in alpha tocopherol concentrations in the body, whereas taking alpha only may suppress or decrease tissue gamma tocopherol. The eight forms of E are wisely delivered in a base of sesame oil, which is naturally high in gamma tocopherol and other components, including restorative lignans.
Your Source of Advanced Nutrition
Epidemiological research and clinical trials have suggested that vitamin E can help maintain healthy blood sugar levels, support healthy cholesterol levels, provide positive effects on the growth and regulation of cells and tissues and even nerve transmission. Source Naturals GAMMA E 400 COMPLEX is the most advanced form of this essential vitamin. We are dedicated to bringing you the finest nutrients modern research has to offer and a better way of life through optimal nutrition and a healthy lifestyle. Make GAMMA-E 400 COMPLEX part of your health plan for more complete nutrition.
L-ARGININE - For Increased Circulation
June 29, 2005 10:16 AM
L-Arginine is an amino acid present in the proteins of all life forms. Under normal circumstances your body can synthesize sufficient quantities from your diet to meet your needs, but in times of stress conditions, such as trauma and wound healing, you may not be able to manufacture enough. L-Arginine’s primary function involves the metabolism of protein and nitrogen. But the scientific community recently became excited about arginine’s newfound role as a promoter of cardiovascular health. L-Arginine is the primary precursor to Nitric oxide, a small molecule that is responsible for relaxing blood vessels. If you are among the many people concerned about your circulatory health, then L-arginine should be a part of your wellness program. Source Naturals L-ARGININE is available in 500 mg tablets or capsules and the convenient higher potency 1,000 mg tablets.
L-Arginine is an amino acid that is found in most proteins consumed in your diet. A small amount is produced in the liver but it is predominantly synthesized in the kidneys. L-Arginine has several roles in the body, such as assisting in wound healing, helping remove excess ammonia from the body, stimulating immune function, and promoting secretion of several hormones, including glucagons, insulin, and growth hormone. It plays an important role in muscle metabolism by working to transport, store and excrete nitrogen. L-Arginine is required by the body to synthesize Nitric oxide, which is produced by all tissues of the body, and plays important roles in the cardiovascular system, immune system and nervous system. Nitric oxide supports blood vessel dilation, which may help circulation.
L-Arginine is a Nitric oxide precursor. Nitric oxide is formed from arginine via the enzyme Nitric oxide synthase or synthasetase (NOS). One of its functions is to regulate smooth muscle contraction. Nitric oxide’s effect on blood vessels is the reason nitroglycerine is prescribed for patients with pain that results from inadequate blood flow to the heart. The nitroglycerine is converted to Nitric oxide, which relaxes blood vessels and in turn reduces the workload of the heart.
L-Arginine is a key nutrient in the energy generating Krebs cycle, where it participates in the detoxification of ammonia. Ammonia is a toxic byproduct of energy metabolism. It is converted to urea and eliminated from the body. Any L-arginine not converted to urea enters general circulation, where it is distributed to various tissues and metabolized for other uses such as protein synthesis.
A Wellness Revolution – Taking Charge of Your Health
Taking personal responsibility for your health is at the heart of the wellness revolution. Mainstream health care has still not caught up to this wellness approach that health food stores have been promoting for decades. Source Naturals is committed to bringing you effective, safe, advanced natural products like L-ARGININE for your lifelong health.
Recognizing the Signs: Roadmap to a Healthy Heart
June 13, 2005 10:06 AM
Recognizing the Signs: Roadmap to a Healthy Heart by Louis McKinley Energy Times, January 2, 2004
From time immemorial, people have tuned into life's lessons that come from the heart. Sadly, times are changing: If you're like most inhabitants of today's harried world, you may be too distracted to detect important clues about your cardiovascular circumstances.
And while heart lessons may be more complicated than simply connecting the physiological dots, understanding those heart messages are imperative for improving and maintaining your heart health.
Every cell in your body relies on heart-powered blood flow to keep it supplied with nutrients, oxygen, hormones and other natural chemicals necessary for survival. Without that supply of life-giving substances, few cells in the body-including those within the heart itself-can survive very long.
And just as damage to a major roadway can cause mayhem with traffic patterns, damage to blood vessels and the heart can wreak a lumpy cardiovascular havoc that blocks the passage of blood and endangers your heart's well-being.
Your Heart Disease Chances
Within the last ten years, scientific research performed by investigators around the world has focused on the specific factors that most strongly influence your chances of developing heart disease and suffering either a heart attack or a stroke.
While much of your risk depends on your genetic inheritance and family history, several factors that determine your heart health are within your control.
The most important factors you can do something about include:
* Smoking: free radicals generated by burning tobacco causes significant damage to blood vessels and other cells
* Lack of exercise: the human body is designed for consistent, moderate physical activity; without exercise, the body slacks off in creating antioxidant protection for arteries
* Diabetes: when excess blood sugar persists, physiological processes begin that endanger the heart and arteries
* Cholesterol: when oxidized (a chemical process that has been compared to a kind of internal rusting), cholesterol can form artery-blocking plaque; antioxidant nutrients like vitamin C and natural vitamin E may help the body limit this process
* High blood pressure: excessive pressure within the blood vessels raises the risk of damage to the heart and arteries; a program of weight loss and exercise can help control blood pressure
* Being overweight: the extra body fat carried around your middle is linked to a greater risk of heart problems
Heart Attack Signs
Do you think you know what a heart attack feels like? Well, if you think it feels like a dramatic pain somewhere in your chest that knocks you to the floor, you're probably wrong. "Most heart attacks do not look at all like what one of my colleagues calls the 'Hollywood' attack-the heart attack you see on television or in the movies," warns Julie Zerwic, MD, professor of surgical nursing who has studied what happens when people develop heart disease and suffer damage to their hearts.
"The symptoms [of heart problems] are not necessarily dramatic. People don't fall down on the floor. They don't always experience a knife-like, very sharp pain. In fact, many people describe the sensation as heaviness and tightness in the chest rather than pain," she says. And, if you're a woman experiencing a heart attack, you may not even feel discomfort specifically in your chest. Instead you may experience a severe shortness of breath. The apparent ambiguity of the discomforts caused by a heart attack lead many people to either ignore them or take hours to realize they need to go to the emergency room at the hospital.
Consequently, much fewer than half of all individuals undergoing a heart attack actually go to a hospital within an hour of the start of the attack. That delay can be a fatal mistake.
"Timing is absolutely critical," laments Dr. Zerwic. "If treatment starts within a hour after the onset of symptoms, drugs that reestablish blood flow through the blocked coronary artery can reduce mortality by as much as 50%. That number drops to 23% if treatment begins three hours later. The goal is to introduce therapy within two hours."
However, in Dr. Zerwic's research, only 35% of non-Hispanic whites go to the hospital within an hour of the start of a heart attack. And among African-Americans, the number of people going to the hospital right away drops to a frighteningly low 13%.
Often, people will lie down or use a heating pad to relieve the tightness they feel in the chest," says Dr. Zerwic. "They may take some medicine and wait to see if that works. All these steps postpone needed treatment."
Signs of a possible heart attack include:
* Chest discomfort: Heart attacks most frequently cause discomfort in the center of the chest that can either go away after a couple of minutes (and come back) or persist. The discomfort may feel like strong pressure, fullness or pain.
* Upper body discomfort: An attack may set off pain or discomfort in either or both arms, and/or the back, neck, jaw or stomach.
* Shortness of breath: Chest discomfort is frequently accompanied by shortness of breath. But it's important to note that shortness of breath can take place even in the absence of chest discomfort.
* Other signs: You can also break out in a cold sweat, or feel nauseated or light-headed.
A Woman's Sleep Signs
If you are a woman who suddenly experiences a marked increase in insomnia and puzzling, intense fatigue, you may be in danger of an imminent heart attack.
In an attempt to understand how women's symptoms of heart problems differ from those of men, researchers talked to more than 500 women in Arkansas, North Carolina and Ohio who had suffered heart attacks. (Technically, what they had experienced is referred to as acute myocardial infarction.)
They found that chest pain prior to a heart attack was only reported by about 30% of the women surveyed.
More common were unusual fatigue, sleep disturbances and shortness of breath (Circulation Rapid Access, 11/3/01).
"Since women reported experiencing early warning signs more than a month prior to the heart attack, this [fatigue and sleep problems] could allow time to treat these symptoms and to possibly delay or prevent the heart attack," says researcher Jean C. McSweeney, PhD, RN, nursing professor at the University of Arkansas for Medical Sciences in Little Rock. In Dr. McSweeney's study, more than nine out of ten women who had heart attacks reported that they had had new, disturbing physical problems more than a month before they had infarctions.
Almost three in four suffered from unusual fatigue, about half had sleep disturbances, while two in five found themselves short of breath.
Other common signs included indigestion and anxiety.
"Women need to be educated that the appearance of new symptoms may be associated with heart disease and that they need to seek medical care to determine the cause of the symptoms, especially if they have known cardiovascular risks such as smoking, high blood pressure, high cholesterol, diabetes, overweight or a family history of heart diseases," says Dr. McSweeney.
Dr. McSweeney warns that, until now, little has been known about signs that women are having heart trouble or heart attacks. The fact that most of Western medicine's past attention has been on heart problems in men has obscured the warning signs in women. As part of Dr. McSweeney's studies, she and her fellow researchers have discovered that more than 40% of all women who suffer a heart attack never feel any chest discomfort before or during the attack.
"Lack of significant chest pain may be a major reason why women have more unrecognized heart attacks than men or are mistakenly diagnosed and discharged from emergency departments," she notes. "Many clinicians still consider chest pain as the primary symptom of a heart attack."
Vitamins for Diabetes and Heart Disease
Having diabetes significantly raises your chance of heart disease, which means that keeping your blood sugar levels under control can reduce your chances of suffering a heart attack.
Today, 17 million Americans have diabetes and, as the country's population in general gains weight and fails to exercise, the number of people suffering this problem continues to grow.
The first line of defense against diabetes consists of exercise and weight control. All you have to do is take a brisk walk for 30 minutes a day to drop your chances of diabetes (American Journal of Epidemiology 10/1/03).
"We have found that men and women who incorporate activity into their lifestyles are less likely to develop type 2 diabetes than those who are sedentary. This finding holds no matter what their initial weight," said Andrea Kriska, PhD, professor of epidemiology at University of Pittsburgh Graduate School of Public Health.
To help your body fight the development of diabetes, researchers also recommend vitamin C and natural vitamin E.
Researchers working with lab animals at the University of California at Irvine have found that these antioxidant vitamins can help insulin (the hormone-like substance secreted by the pancreas) reduce harmful blood sugar. In addition, these vitamins shrink the chances of organ damage that can be caused by diabetes (Kidney International 1/03).
In this investigation, these vitamins also helped reduce blood pressure, another risk factor that raises heart disease risk.
"Blood pressure was lowered to normal, and free radicals were not in sufficient numbers to degrade the sugars, proteins and Nitric oxide," notes Nick Vaziri, MD, professor of medicine at the University of California. "We think this shows that a diet rich in antioxidants may help diabetics prevent the devastating cardiovascular, kidney, neurological and other damage that are common complications of diabetes."
Free Radical Blues
Dr. Vaziri and his group of researchers found that untreated diabetes raised blood pressure and increased the production of free radicals, caustic molecules that can damage arteries and the heart. Free radicals can change blood sugar and other proteins into harmful substances, boosting tissue and heart destruction.
In Dr. Vaziri's work with lab animals, he found that treating diabetes with insulin lowered blood pressure and helped keep sugar and protein from changing into dangerous chemicals, but allowed the free radicals to subvert Nitric oxide, a chemical the body uses to protect itself from free radicals.
In this investigation, adding vitamins C and E to insulin insulated the body's sugars, proteins and Nitric oxide from oxidative assault. This produces a double advantage: Lowering the risk of heart disease and other damage to the body from diabetes.
Maitake, an Oriental mushroom that has been shown to have many health benefits, can also be useful for people with diabetes who are trying to avoid cardiovascular complications. Laboratory studies in Japan demonstrate that maitake may help lower blood pressure while reducing cholesterol (Biological & Pharmaceutical Bulletin 1997; 20(7):781-5). In producing these effects, the mushroom may also help the body reduce blood sugar levels and decrease the risk of tissue damage.
Tobacco smoke is one of the most notorious causes of heart problems. In the same way a hard frost exerts a death grip on a highway, the smoke from cigarettes can freeze up arteries and hamper their proper function. A healthy artery must stay flexible to comfortably allow adequate circulation.
But "...when blood vessels are exposed to cigarette smoke it causes the vessels to behave like a rigid pipe rather than a flexible tube, thus the vessels can't dilate in response to increased blood flow," says David J. Bouchier-Hayes, MD, professor of surgery at the Royal College of Surgeons in Ireland, who has studied the deleterious effects of tobacco.
This rigidity is called endothelial dysfunction. When arteries are rigid, blockages gum up vessels, clots and other impediments to blood flow appear, and your risk of heart attack and stroke increases (Circulation 2001 Nov 27; 104(22):2673).
This condition can also cause chest pain (angina) similar to that caused by a heart attack, and should be evaluated by a knowledgeable health practitioner.
Although all experts recommend you stop smoking to lower your heart disease risk, some studies have found that Pycnogenol(r), a pine bark extract that helps the body fight inflammation, may ease some of smoking's ill effects.
In a study of platelets, special cells in the blood that can form dangerous blood clots, researchers found that Pycnogenol(r) discouraged platelets from sticking together (American Society for Biochemical and Molecular Biology 5/19/98). By keeping platelets flowing freely, this supplement may alleviate some of the heart-threatening clots that tobacco smoke can cause.
In Ayurvedic medicine, a traditional therapy from India, an herb called guggul has also been used to lower the risk of blockages in arteries. This herb, derived from the resin of the mukul tree, has been shown to reduce cholesterol by about 25%. People taking this herb have also reduced their triglycerides (harmful blood fats) by the same amount (Journal Postgraduate Medicine 1991 37(3):132).
The Female Version of Heart Disease
For one thing, women often don't suffer from the crushing chest pain that for most people characterizes a heart attack; instead, many women experience back pain, sweating, extreme fatigue, lightheadedness, anxiety or indigestion, signs that can be easily misread as digestive troubles, menopausal symptoms or indicators of aging.
The genders also differ in how heart disease poses a threat. While men seem most endangered by the buildup of blockages in arteries, women apparently are more at risk from endothelial dysfunction. But more study needs to be done since, in many cases, researchers have been unable to pin down the precise mechanism that causes many women to die of heart disease.
Scientists have found that the number of women in their 30s and 40s who are dying from sudden cardiac arrest is growing much faster than the number of men of the same age who die of this cause. But research by the Oregon Health & Sciences University and Jesse E. Edwards Cardiovascular Registry in St. Paul, Minnesota, shows that while doctors can pinpoint the coronary blockages that kill men, they can't find specific blockages in half of the female fatalities they have studied (American Heart Journal 10/03).
"This was an unexpected finding. However, the study underscores the need to focus on what is causing these younger women to die unexpectedly because the number of deaths continues to increase," says Sumeet Chugh, MD, a medical professor at Oregon.
Since the failure of arteries to relax probably contributes to heart disease in many women, eating red berries, or consuming supplements from berries such as chokeberry, bilberry or elderberry, may be important in lowering women's heart disease risk. These fruits help arteries expand and allow blood to flow freely.
Red berries are rich sources of flavonoids, polyphenols and anthocynanins. The anthocyanins are strong antioxidants that give the berries their color. Research at the Indiana University School of Medicine have found that these chemicals can interact with nitrous oxide, a chemical produced by the body, to relax blood vessels (Experimental Biology conference 5/20/02).
As researchers work to devise lifestyle roadmaps that can steer you around the perils of heart disease, they are finding that exercise is a key path to avoiding cardiovascular complications.
A 17-year study of about 10,000 Americans found that those who exercised and kept their weight down (or took weight off and kept it off) experienced a significantly lower risk of heart problems (Preventive Medicine 11/03).
"The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, of the Albert Einstein College of Medicine in the Bronx, New York. Burning calories in physical activity may be the secret to reducing heart disease risk and living longer, she says.
Dr. Fang's research used information collected from the First National Health and Nutrition Examination Survey in 1975 and then computed how much people exercised, how their body mass indices varied and which of these folks died of heart disease during the next two decades.
In the study, more than 1,500 people died of heart disease. Those who worked out and consumed more calories cut their risk of heart disease death in half.
Exercise Is Essential
"Subjects with the lowest caloric intake, least physical activity, and who were overweight or obese had significantly higher cardiovascular mortality rates than those with high caloric intake, most physical activity, and normal weight," Dr. Fang notes. The individuals in the study who were overweight and didn't exercise had a bigger risk of heart disease even if they tried (and succeeded) at eating less.
"This suggests that heart disease outcome was not determined by a single factor, but rather by a compound of behavioral, socioeconomic, genetic and clinical characteristics," according to Dr. Fang.
According to researchers, if your job requires a great deal of physical activity, your health will be better if you get another job. Exercise on the job not only doesn't decrease your risk of heart disease, it may actually raise it. The reason: On-the-job activity is linked to heart-endangering increases in job stress.
Research into this subject, performed at the Keck School of Medicine of the University of Southern California, found that while recreational exercise slowed hardening of the arteries, workers who had to exert themselves during the workday had arteries that were blocked at a younger age (American Journal of Medicine 7/03).
In this study, researchers examined about 500 middle-aged employees as part of what is called the Los Angeles Atherosclerosis Study.
"We found that atherosclerosis progressed significantly faster in people with greater stress, and people who were under more stress also were the ones who exercised more in their jobs," says James Dwyer, PhD, professor of preventive medicine at the Keck School. According to Dr. Dwyer, "This suggests that the apparent harmful effect of physical activity at work on atherosclerosis-and heart disease risk-may be due to the tendency of high-activity jobs to be more stressful in modern workplaces.
"It appears from our findings that the psychological stresses associated with physically active jobs overcomes any biological benefit of the activity itself."
On the other hand, the scientists found that heart disease drops dramatically among those who exercise the most in their spare time. In the study, people who vigorously worked out at least three times a week had the lowest risk. But even those who just took walks enjoyed better heart health than people whose most strenuous activity was working the TV remote. Dr. Dwyer says, "These results are important because they demonstrate the very substantial and almost immediate-within one or two years-cardiovascular benefit of greater physical activity."
Lowering your risk of heart disease is substantially up to you. Listen to what your heart tells you it needs; then, exercise your right to fetch some cardiovascular necessities.
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research
on Cancer and Cardiovascular Disease
Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.
“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”
Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”
Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .
PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892
Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.
INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA
Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.
INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany
Endothelial dysfunction (ED) due to decreased bioavailable Nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
David Heber, MD, PhD, FACP, FACN
Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center
Matthew Budoff, MD, FACC
Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.
Intimate Response - The Freedom to Change. Boost intimacy
June 02, 2005 12:48 PM
SENSUALITY AND MENOPAUSE. FOR MANY WOMEN THIS apprehensive milestone is foreshadowed by disquieting physiological changes. Its debut marks a transition period that can actually begin at age 40. Called pre-menopause, it usually lasts 3 to 6 years and is characterized by powerful hormonal changes with wide-ranging effects on a woman’s body. Her level of romantic passion is often influenced by these changes. Source Naturals is proud to announce ETERNAL WOMAN™ INTIMATE RESPONSE™. This herbal-safe, natural formulation may support a woman’s healthy vitality and vigor during pre-menopause.
Healthy Circulation = Natural Vitality.
Most women experience decreases in desire at one time or another. Activity levels, monthly hormonal changes, circulatory status, drugs such as oral contraceptives and anti-depressants, alcohol and emotional factors all may contribute to a woman’s passion. However, premenopause is something more. Hormones stimulate, affect and balance hundreds of processes during a woman’s monthly cycle. When their levels begin to fluctuate and decline during premenopause, the body’s internal balancing act is acutely influenced. The bloodstream is our “river of life” as it delivers oxygen and nutrients throughout the body. Maintaining adequate blood circulation is necessary to our health and vitality. INTIMATE RESPONSE contains these supportive herbs and nutrients: yohimbe, epimedium, Ginkgo biloba, Panax ginseng, and L-Arginine.
The Nitric Oxide Connection.
L-Arginine is the primary amino acid t hat the body uses to make Nitric oxide. It is Nitric oxide that helps the muscle tissues surrounding a blood vessel to relax, allowing more blood to flow to the organs. Panax ginseng is a highly valued botanical traditionally utilized as an energizing tonic. In use for thousands of years in China, its main active constituents are the ginsenosides. Ginkgo extract is traditionally the premier herb for supporting blood flow in the circulatory system. Pregnenolone is the starting point from which all sex hormones are produced internally. Yohimbe is an African herb that has traditionally been used for more than 100 years. It supports peripheral blood vessels. Epimedium and dong quai are highly valued blood tonic herbs in traditional Chinese medicine used to support circulation and “life essence.” Vitamin B6 and folic acid support proper blood flow and healthy arteries by reducing levels of homocysteine in the bloodstream.
The Healthy, Herbal-Safe Response.
INTIMATE RESPONSE is a remarkable combination of herbal-safe, gentle ingredients that may support healthy and normal circulation during pre-menopause. For the freedom to change™ naturally...choose INTIMATE RESPONSE by Source Naturals.
Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort
June 02, 2005 12:37 PM
It happens. You reach for something and feel a sudden discomfort. Your joints and muscles may feel tender from overuse. Inside, your cellular systems are out of alignment, resulting in lessened mobility. Source Naturals understands how difficult joint discomfort can be to live with. We are deeply committed to developing well-researched formulas that address the root cause of joint distress. Our Bio-Aligned Formulas™ bring alignment to multiple interdependent body systems. Only this type of indepth formulation can provide the long-term relief you are looking for. Regain your comfort with Source Naturals INFLAMA-REST. Unlike many products that contain just a few ingredients to offer temporary relief, INFLAMA-REST is a Bio-Aligned Formula™, scientifically designed to address aches. INFLAMA-REST goes deep to the underlying cause of joint discomfort. These systems include: inhibition of pathways involved in joint discomfort, joint and muscle function, DNA protection and antioxidant defense.
Addressing Joint Comfort on a Deep Cellular Level
Discomfort can come from many places. From your head to your toes there are many tissues that can become uncomfortable from everyday use. Joint discomfort starts when stress, such as tissue damage, causes an imbalance of the biochemical pathways on a deep cellular level. The body has its own “innate intelligence” encompassing more than just the thoughts in the brain. It consists of ongoing and complex chemical reactions regulated by a wide variety of enzymes and chemical messengers. These reactions can sometimes get out of balance – but you can control and inhibit key body chemicals that would otherwise lead to cellular irritation. For example, certain types of prostaglandins that regulate normal physiological functions such as blood flow, are maintained at low levels in all our cells under everyday conditions. In response to stress, a message is sent to the outer membranes of certain cells to convert their fatty acids into arachidonic acid, the raw material for prostaglandins. This stress also directs cells to produce Cyclooxygenase enzyme- 2 or COX-2. This enzyme converts arachidonic acid into Prostaglandin E2, a particular type of prostaglandin specifically responsible for irritation on a cellular level. The result: joint discomfort. But that doesn’t have to happen. By supporting inhibition of the culprit COX-2, you can decrease Prostaglandin E2 production to bring your joint tissues back into a healthy and comfortable balance.
INFLAMA-REST includes herbs that support inhibition of COX-2 in a variety of pathways. Ginger, turmeric and green tea all support direct COX-2 inhibition. But there are other places in our biochemical communication system where COX-2 production can be inhibited. Two additional factors that lead to COX-2 production are Nitric oxide and the enzyme that produces it, Nitric oxide synthase (iNOS). Nitric oxide is a free radical associated with cell growth and regeneration, blood vessel elasticity and COX-2 enzyme production. Resveratrol, rosemary and turmeric support iNOS inhibition, thus inhibiting your body’s over-production of Nitric oxide and the COX-2 enzyme. A related irritation factor is also one of the latest scientific discoveries in cellular health - Nuclear Factor kappa-B (NF-kappa-B). NF-kappa-B works at the DNA level – at the blueprints of cells. When activated, this factor controls the genes that regulate cell growth, differentiation and regeneration. And blocking this factor is also associated with inhibition of both COX-2 and iNOS enzymes. Stinging nettle, milk thistle and Chinese Skullcap all block unhealthy NF-kappa-B activation in your body and thereby help support COX-2 inhibition.
Compounds called cytokines, or interleukins, can also stimulate biochemical pathways leading to joint discomfort. Cytokines are chemical messengers produced by the immune system to regulate defensive activity when they are stimulated. For example, cytokines are released by macrophages in response to stimuli such as tissue damage. This results in rapid escalation and amplification of cell number and response. Constant stress can shift this system out of balance, resulting in tissue discomfort. Bringing these compounds back into balance can preserve your short-term comfort and longterm health. INFLAMA-REST contains curcumin from the spice turmeric. Curcumin assists the body’s inhibition of cytokine activity to support reduced cellular irritation. And Bioperine®, which is derived from black peppercorns, is added to assist curcumin assimilation.
Stress Response: Joints and Muscle Support
Inhibition of chemical messengers involved in joint discomfort is just part of a Bio-Aligned strategy for relieving discomfort. Research has shown that emotional stress, particularly long-term, can directly affect the body and set in motion mechanisms that cause physical discomfort. Ashwaganda and Chinese Skullcap (S. baicalensis) are herbs that help modulate the body’s response to stress and may help ease aches and discomfort. Boswellia, ginger, quercetin, milk thistle, feverfew, Oregon grape root and bromelain (an enzyme found in pineapples) provide additional soothing relief to your cells and tissues. Essential nutrients are also vital to maintaining your joint comfort. The tocotrienol forms of vitamin E, along with selenium, protect cell membranes from lipid-based free radicals. Magnesium aids energy metabolism in muscles and can reduce tenderness as well as muscle spasms. Zinc is essential for normal cellular repair mechanisms such as wound healing and is important for the growth and maintenance of connective tissue. And manganese works to protect cells from oxidation and to build healthy connective tissue as well, an essential component of healthy joints and muscles.
Protecting Your DNA
To reduce cellular irritation, you need to protect the DNA in your cells. DNA is the blueprint for all of the molecules in the body. If your DNA is altered or damaged, then needed molecules may not be produced, leading to short-term and eventually long-term damage. Curcumin, from turmeric, has been shown in in-vitro studies to protect DNA against strand breakage. Quercetin has also been shown to directly protect DNA against strand breakage and base oxidation from free radicals and damaging chemicals, according to recent in-vitro research.
Providing Powerful Antioxidant Cellular Protection
Antioxidants are selfless bodyguards of your cells. They donate their own electrons to stabilize free radicals in your body. Thus, antioxidants absorb the damage that would have been done to your tissues. Some regulatory chemicals, such as Nitric oxide, are powerful free radicals and oxidants. Oxidants also activate NF-kappa-B. Tissues, lipids, proteins and DNA are extremely sensitive to oxidation. Quercetin, milk thistle, turmeric, ginger, rosemary, vitamin E and resveratrol are all antioxidants that help modulate the activity of these compounds as well as protect cells and tissues from damage. Plus, Superoxide Dismutase (SOD), one of the most important enzyme antioxidants found in your body, has been added in a new cutting-edge form. The vegetarian SOD used in INFLAMA-REST is attached to Gliadin, a wheat protein, that has demonstrated significantly better absorption than SOD alone.
Six Lifestyle Strategies for Fewer Aches
Inhibition of COX-2: Turmeric, Ginger, Chinese Skullcap, Green Tea, Resveratrol, Boswellia, Silymarin, White Willow Inhibition of Cytokine Turmeric, Stinging Nettle, Feverfew Inhibition of Rosemary, Green Tea, Resveratrol, Turmeric, Quercetin, Chinese Skullcap NF-kappa-B Activation Silymarin, Chinese Skullcap, Stinging Nettle, Rosemary, Resveratrol Stress Response: Ashwaganda, Magnesium, Chinese Skullcap, Oregon Grape, Feverfew, White Willow DNA Protection Turmeric, Quercetin, Rosemary Antioxidant Defense Silymarin, SOD Gliadin, Turmeric, Rosemary, Tocotrienols, Resveratrol, Ginger, Selenium, Manganese, Zinc Prostaglandin & Leukotrine Synthesis Joint & Muscle Support Inhibition of Nitric Oxide Synthesis Production
Garlic Prevents Hypertension Induced by Chronic Inhibition ...
May 12, 2005 12:59 PM
Garlic Prevents Hypertension Induced by Chronic Inhibition of Nitric Oxide Synthesis.
Garlic Elicits a Nitric Oxide-Dependent Relaxation and...
May 12, 2005 12:39 PM
Garlic Elicits a Nitric Oxide-Dependent Relaxation and Inhibits Hypoxic Pulmonary Vasoconstriction in rats.
3. Acetylcholine (0.1 micromol/L)-induced NO-dependent relaxation was reduced from a control value of -76 +/- 1% to -46 +/- 4% during hypoxia and was further reduced to -35 +/- 2 % after reoxygenation.
5. Pretreatment with NG-nitro-L-arginine methyl ester abolished the early transient contraction, moderately attenuated the sustained contraction and had no effect on the transient relaxation. Mechanical endothelial disruption inhibited all hypoxia-induced vascular changes.
7. Garlic also significantly inhibited endothelin-l-induced contractions in a dose-dependent manner.
8. These findings show that garlic extract modulates the production and function of both endothelium-derived relaxing and constricting factors and this may contribute to its protective effect against hypoxic pulmonary vasoconstriction.