Search Term: " PHASE "

	Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?	Darrell Miller	12/7/23
	Study shows benefits of vitamin C in treating cancer	Darrell Miller	2/1/19
	Why the Indian olive is one of the best superfoods of all	VitaNet, LLC Staff	9/2/18
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	HOW TO FIX ALL YOUR SLEEP PROBLEMS WITH THIS TWO NATURAL INGREDIENTS!!	Darrell Miller	9/2/17
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	Why high-dose vitamin C kills cancer cells	Darrell Miller	1/22/17
	Benefits of stress management	Darrell Miller	11/30/16
	What is the Krebs cycle and why is it important?	Darrell Miller	8/16/15
	Expelling Parasites and Worms with Black Walnuts	Darrell Miller	8/7/15
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Date: December 07, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body.

While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption.

GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age.

The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels.

In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body.

This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form.

But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them.

So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing!

Liver Health

When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ.

Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds.

During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances?

But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker!

The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning.

So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being!

Alcohol Intoxication

Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells.

To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes.

The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group.

The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver.

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels.

Recognizing the substantial role glutathione (GSH) plays in PHASE 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy.

In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management.

Beautiful Skin

By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions.

Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores.

Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects.

Skin Lightening

Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract.

The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women.

In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH.

Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin.

The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities.

In summary, the administration of glutathione, whether oral, buccal, or topical, has shown promising results in skin lightening and the improvement of complexion. Studies have demonstrated that glutathione not only enhances skin brightness but also reduces hyperpigmentation, wrinkles, and minimizes pores. Moreover, its effects have been evident in as little as two weeks, with a sustained impact over longer periods. These benefits were observed across a range of different skin types and ethnicities. However, it is important to highlight that these findings are based on specific populations, and more research needs to be conducted to confirm the consistency of these effects across a broader spectrum of skin types and ethnicities. The studies have also confirmed that the usage of glutathione is well-tolerated with no serious adverse effects reported.

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Date: February 01, 2019 08:50 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Study shows benefits of vitamin C in treating cancer

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Date: September 02, 2018 05:53 PM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Why the Indian olive is one of the best superfoods of all

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Date: May 31, 2018 05:16 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Will CBD Oil Help Me Sleep?

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Date: September 02, 2017 05:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: HOW TO FIX ALL YOUR SLEEP PROBLEMS WITH THIS TWO NATURAL INGREDIENTS!!

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Date: July 19, 2017 07:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Is CBD the Next Big Thing for Acne?

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Date: February 06, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Toxins in Your Fast-Food Packaging?

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Date: January 22, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Why high-dose vitamin C kills cancer cells

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Date: November 30, 2016 01:53 AM
Author: Darrell Miller
Subject: Benefits of stress management

Mental Health can be overlooked in our everyday lives but it plays a huge role in our health. Our mental state can affect us in many ways both positively and negatively. This article will be discuss the importance of Mental Health with a concentration on stress management. Stress is a significant cause of mental illness today and although we can't eradicate it, we can manage it It is important to understand that not all stress is negative. Stress may occur prior to weddings, graduations, or even social gatherings, but no matter the source of stress, your bodies respond the same. Also, some stress is good for you in order to manage skills needed for survival such as fight or flight.

Experts suggest a combination of physical, social, environmental, and psychological approaches to managing stress. When we are stressed, we encounter General Adaptation Syndrome (GAS). GAS is your complex physiological responses that happen as a result of the stress and has three PHASEs. The first PHASE of GAS is the alarm PHASE. The alarm PHASE occurs when we sense there is a stressor present (Body doesn't sense whether it is a good or bad stressor), everything becomes heightened and hormones respond. The seconds PHASE of GAS is called the resistance PHASE. During the resistance PHASE your body resists stress to get your it back to homeostasis. If you can't rid the stress you move into exhaustion The last PHASE, exhaustion, occurs when your body is tired and can't fight anymore to get it back to homeostasis. Physical or emotional tension is often a good indicator of stress.

Below is a short list of symptoms from stress.

• Tension and irritability
• Fear and anxiety about the future
• Difficulty making decisions
• Being numb to one's feelings
• Loss of interest in normal activities
• Loss of appetite

Take Care of Yourself

Stay Active

Social Support

Avoid Alcohol or Drugs

In conclusion chamomile will help you zap stress and unwind and have healthy life.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3535)

Date: August 16, 2015 07:14 PM
Author: Darrell Miller
Subject: What is the Krebs cycle and why is it important?

The Krebs cycle is a series of chemical response that helps in the production of Adenosine triphosphate (ATP) and carbon dioxide, a compound that is rich in energy.  This cycle happens with the combination of two carbon coenzymes and carbon complexes and goes through a series of changes to produce the required energy that is needed for the smooth functioning of living organism.  This cycle occurs in all the cells that use oxygen for their respiration process.  Carbon dioxide has an important role since it fuels breathing and the ATP also plays a vital role as it provides cells with a required energy for synthesis of proteins from amino acid and the reproduction of deoxyribonucleic acid.  These are considered essential for energy supply and for the continuation of any kind of life including human.

The Krebs cycle is known as the second PHASE of the aerobic respiration.  Aerobic respiration is composed of three PHASEs, Glycosis is the first PHASE, followed by the Krebs Cycle, and last is the Electron PHASE.  These three stages are a series of a cycle that all living cells must experience to produce the required energy for the smooth functioning of the mechanism of life.

Why Krebs cycle is important?

Poor digestion, fatigue and lack of proper nutrition are the common complaints among the people of all ages all over the world.  This complaint comes when the body does not get proper nutrition or is unable to digest food even if it's available.  It leads to a chronic problem and makes most of the people suffer. But what makes them suffer? This is the listless metabolism that ultimately leads to slow Krebs cycle function. When Krebs cycle does not function properly, after a period of time it causes the accretion of undigested food remains in the blood vessels and also creates some other health complications such as constipation, fatigue and smoggy brain.  In the long run, it can create some other health complication that is severe and sometimes life-threatening. So to avoid this situation people usually prefer to take the Krebs cycle supplement.  This supplement resolves all these issues and also makes you feel energetic.

Why your body is reliant on Krebs cycles?

Krebs cycles are important since it helps to generate energy from the food, particularly from the carbohydrate. And you can get carbohydrate from grains, cereals, fats and also from vegetable and animal sources. You can also get carbohydrates from the proteins.

By definition, carbohydrates are the combination of three important things, carbon, hydrogen and oxygen and these things can be changed to glucose inside your body. Initially your body uses the carbohydrate as the foundation of glucose and then through a series of processing, the body gets the required amount of carbohydrates from the diet. And here Krebs cycle plays an important role to generate energy from the carbohydrate.

The Krebs cycle is considered important for producing energy, it does not help you to run fast and to be active only, and it also enables your metabolic process to work efficiently.

References:

//www.wisegeek.org/what-is-the-krebs-cycle.htm

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Date: August 07, 2015 07:35 AM
Author: Darrell Miller
Subject: Expelling Parasites and Worms with Black Walnuts

Parasites and worms are responsible for a number of health problems all over the world.  These organisms invade our bodies and feed on nutrients for their own sustenance.  Parasites can be both internal and external in nature. External parasites can generally be seen and are easier to get rid of.  You will find a number of standard medical treatments for this. However, it is the internal parasites that pose the higher threat.  It can be difficult to identify internal parasites and treatments require more effort.  These parasites usually attack the colon and intestines.  If left unchecked, they can cause a lot of damage to your body. While antibiotics are effective, they can have a few side effects.  So people have been looking for more natural alternatives.  Black walnut has shown a number of properties that are beneficial in fighting parasites.

How does Black Walnut help in killing parasites and worms?

Black walnut has been universally acknowledged to be a strong vermifuge, that is a parasite-killing herb.  It has strong concentrations of Natural iodine, juglone and astringent tannins.  All these ingredients are well known for their parasite killing properties. One of the best methods of ingesting black walnut is by preparing a medicine that utilizes other similar organic foods like garlic, pineapples, papaya seeds and pumpkin seeds.  This helps clean the intestines and remove parasites and worms.

What are the effective black walnut recipes?

One of the most popular recipes involves using black walnuts, cloves and wormwood.  There are many products that utilize this combination and have been seen to give impressive results. Of course it also depends on the potency of the ingredients used.  For example, green black walnuts are generally known to be more effective than other lighter colored ones.  So it could be a good idea to look for these specific walnuts in the ingredients label.  They are likely to be stronger and can get faster results.  You will also see a number of freeze dried capsules available in the market that have a higher strength compared to normal medicines. Wormwood is herb that has been used in stomach treatment for centuries. It contains a number of enzymes that are good for cleaning the intestine. Hence, it can be found in conjunction with black walnut in medicines that fight parasites. With cloves too you should be careful, as they tend to lose their potency very fast.   So make sure that your medicine uses only fresh and completely organic cloves. You can either go in for manufactured pills that use these ingredients or can create your own recipes. Just make sure that you are using only the most effective constituents.

Apart from these herbs, you will also find a number of other natural solutions for getting rid of parasites and worms. These include papayas, pineapples and pumpkin seeds. Papayas can be highly effective as they contain a strong enzyme known as papain.

What other steps can I take?

If you are going through a parasite expelling PHASE, it will be good to regulate your diet in a proper manner. Avoid coffee, sugar, alcohol and other such items. Take care of your stomach and eat only fresh and light food. With a good diet, and the right herbs, you will soon be having a completely parasite-free body.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3190)

Date: April 19, 2014 05:36 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Silica Supplements for Healthy Bones

Silica

For a long lasting, the part of silica in the body was not known. Right away, it is around the paramount minerals. It can luckily be found in the vast majority of the vegetables and apples and oranges. Analysts have named silica as of late into the class of the most essential minerals for the body. Nutritionists assess that a grown-up might require 20 to 30 mg for every day.

Health benefits of silica

This mineral helps the body to develop the bones, the teeth, the cartilages, the tendons and the hair, giving further safety. Silica additionally gives the skin suppleness and the vascular dividers versatility. An eating regimen rich in silica can avoid osteoporosis, atherosclerosis (thickening of blood vessel dividers), skin wrinkling, diminishing and balding, broken nails and tooth rot. It makes the teeth, the nails and the hair to sparkle. Silica exists in lung tissue, so it is prescribed for the re-mineralization handle in tuberculosis patients. Since it serves to develop bone and cartilage, this mineral must not be absent from the eating methodologies of pregnant women and kids experiencing rickets. Additionally it helps acclimatize phosphorus, which is exceptionally imperative for the cerebrum wellbeing.

Silica sources

Luckily, silica is found in numerous nourishments we consume regularly, and particularly in leafy foods. A percentage of the wealthiest sources are the entire grains, the pieces of fruit and oranges, lemons, grapes, raisins, almonds, peanuts, nuts, grains by and large, cabbage, carrots, squash, green beans, cucumbers, mushrooms, onions, leeks, parsnips, weeds and radishes. From these, the entire grains hold a type of silica, which is not difficult to absorb. Corn shelled and results of it (white bread, for instance) do not hold silica. Besides, all refined or prepared items lose their supplements, including silica. Lager and nectar have additionally a substantial amount of this mineral in their creation. It exists even in water in diverse amounts, depending from on the land zone. Around the creature sustenance sources, fish is the particular case that holds silica. Since the nourishments holding this mineral are such a large number of, we can give our body, for the most part without issues, the everyday necessity. Silica lack is uncommon. It happens in individuals who consistently consume foods grown from the ground and the elderly, because the mineral is more troublesome to absorb with age.

The vicinity of silica in the body is exceptionally imperative. The mineral is fundamental for calcium ingestion especially in the early PHASEs of bone development, additionally for supporting skeletal wellbeing all around life. It is included in framing collagen and that is the reason it is vital for the strength of nails, skin and hair. Silica is additionally important to keep the adaptability of corridors, and assumes a real part in averting cardiovascular illnesses. It animates the insusceptible framework and deferrals the maturing procedure of tissues. The level of this mineral in the body diminishes with age. In this way, more seasoned individuals require a higher admission of silica, contrasted with ones that are more youthful.

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Date: November 04, 2013 05:06 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Chlorella Improve Your Health?

 What is Chlorella

Chlorella is made by two cycle periods that determine the total cell size and length. A timer usually runs through the G1 PHASE and it leads to the cell attainment prior to S PHASE without further growth requirement. The cycle is consistent with increments of size control. It multiplies rapidly through photosynthesis and requires only three basic conditions to reproduce namely; water, carbon dioxide and sunlight. There are various health benefits of chlorella including;

Vitamins

Chlorella is rich in various types of vitamins including; A, B1, B2, B6, B12, C and E. It provides the nutrients as a whole food bundle that is way superior than manufactured formula.

Minerals

Chlorella is rich in magnesium that helps in improving blood sugar levels, mental health and heart health. It also contains other rich minerals including; iron, potassium and calcium.

Amino Acids

Chlorella is a rich protein source and it also contains important amino acids. The amino acids are used by the body for rebuilding neurotransmitters and lean tissues.

Detoxification

Chlorella is very effective in binding with toxic chemicals and heavy metals. The toxins are removed from the body hence bringing a positive health impact.

Energy

Chlorella increases the body energy. It is also very effective in elevating moods and it is way stronger than taking super food.

Cancer

Chlorella has amazing cancer-fighting abilities due its rich natural carotenoids that prevent oxidation. It also has the ability to nourish the system.

Diabetes

Chlollera helps to improve blood sugar levels and insulin over time. It can also improve insulin resistance and diabetes.

Heart Disease

Chlollera offers protection against heart disease by improving LDL cholesterol and triglyceride. It also has strong antioxidant properties.

Obesity

Chlollera has unique properties that can lower body fat. It can also improve insulin sensitivity and aid fat metabolism.

Reference: 

www.jstor.org, www.naturalnews.com

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Date: February 19, 2012 08:14 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Do Carbohydrate Blockers Like White Kidney Bean Extract Work?

Weight Loss And Carb Blockers

With so many weight loss products available in the market, it becomes difficult to find the right one that actually works. Many dieters are turning to starch blockers such as White Kidney beans that help in reducing the absorption of carbs in the body, hence getting rid of extra flab. Let us look at the science behind starch or cabohydrate blockers.

How does Carbohydrate Blocker work?

Starch is the non-nutritious and empty calorie form of carbohydrate that is found in bread, pasta, rice and potatoes. These evil foods have become the staple diet of many people. During the process of digestion, all the forms of carbohydrates are converted in to simple sugars. Sugar is further metabolised for energy, and excess sugar is stored either in the muscle tissue and liver or in the form of fat deposits. This breaking down of carbs is done with the help of an enzyme, alpha amylase. Recent studies have found that some substances contain specific ingredients that help in blocking the enzyme amylase. This ingredient is known as PHASE 2 Carb Controller and it blocks tha action or function of alpha amylase. This results in slowing down of absorption and digestion processes. This reduces conversion of extra sugar in to fat and hence reduces calorie impact. So actually it is not starch blocker, as they do not block everything; rather it is starch enzymen blocker.

White Kidney Beans as Carbohydrate blocker:

White kidney beans are large beans that can be used to prepare soup and pasta dishes and other italian dishes. They are also called cannellini beans and have a mild delicious flavor. It has been studies that white kidney beans contain a specific ingredient called PHASE 2 Carb Controller that helps in blocking the action of enzyme alpha amylase. According to the latest studies, white kidney beans may help the body stop carbs from breaking down in to sugars, hence there is no excess sugar to get converted in to fat. Experts say that PHASE 2 Carb Controller selectively targets only the starchy white component of carbohydrates and do not affect the digestion of healthy carbohydrates such as whole grains and fruits. It inhibits body's digestion of specific complex carbs, which are then eliminated from the body. This helps you get rid of unhealthy stored fat, giving you healthy, fat free body.

What are the other benefits of White kidney beans that may assist in weight loss:

According to studies, white kidney beans also help in regulating the blood sugar levels. Normal blood sugar levels do not require breakdown of complex carbs and this also helps in losing weight.

White kidney beans also contain high amounts of fibre, which aids in digestion and keeps you satisfied, thereby avoiding untimely bingeing of high calorie snacks.

Other health benefits of White kidney beans:

White kidney beans are useful in lowering triglycerides, coronary artery disease and degenerative arthritis.

Clinical studies on white kidney beans or starch blockers have shown that carbohydrate blocker do allow complex carbs to pass through the small intestine undigested. Research is still going on to find the further action of PHASE 2 Carb Controller present in white kideny beans in losing weight.

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Date: February 08, 2012 08:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does The White Kidney Bean Block Carbohydrates?

The White Kidney Bean is referred scientifically as PHASEolus vulgar. It is bean plant that is native to the Indies, Europe and Peru. The major advantage of using this bean plant is because it has been proven scientifically proven as a good inhibitor of the digestion of some selected dietary carbohydrates. Its carbohydrate blocking ability has seen it being adopted in the manufacture of most weight loss and diet pills.

When you consume starch, normally referred to as the complex carbohydrates, the body then has the responsibility of breaking these food substances into smaller digestible units that are referred to as dextrins. This is usually done through a chemical process catalyzed by the enzyme amylase. The dextrins are later broken down to form glucose. This is then the product that is useful to the body. Glucose is required for body energy requirements. The glucose before being used by the body system is first stored in the muscle tissue or the liver in the form of glycogen.

The settling of glycogen in the liver is used for conversion to lipids and later their storage in fat form. White Kidney Bean is essentially used to block the digestive ability of alpha-amylase which is used in the breakdown of carbohydrates into dextrins and later into glucose which is then used up by the body system. The result of this means that all the carbohydrates pass through the digestive tract undigested. This therefore translates to a lower intake of energy and. This subsequently lowers the amount of body fat that is usually introduced into the body by the consumption of such foods. This is why this bean is an essential element for those seeking to lose weight.

The White Kidney Bean can be able to block the digestion of carbohydrates but is not capable of inhibiting the digestion of fats and simple sugars. This therefore calls for more adoption of dietary controls because the bean might not achieve the level of effect required. Even through the bean is able to inhibit the functioning of alpha-amylase, there still is another starch digestive enzyme called glucoamylase that can still be digesting the starch during the inhibition of the other enzyme. The White Kidney Bean is a good option for weight loss and weight management. The users are however still advised to ensure that they properly limit their intake of carbohydrates so as to get better results.

This bean is safe to take and does not have any health complications associated with it. The use of this bean is of much importance in losing that extra pound. The White Kidney Bean is especially helpful to those people who cannot get the proper time for preparing healthy meals. It is always important to keep in mind the fact that this bean is only useful in inhibiting the digestion of carbohydrates. This is why people are always advised to try as much as possible to limit their carb consumption. Some side effects like heartburn might be witnessed but in most cases they might not be very much pronounced.

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Date: December 16, 2011 06:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Are The Different Types Of Ginseng And What Is Ginseng Good For?

Ginseng is a considered to be a perennial plant which is a member of the Panax genus under the family of Araliaceae. It is abundantly found in North America, East Asia and other places which have a cool climate. There are many types of ginseng. Though different in kind, all these species of ginseng contains the active ingredient known as ginsenosides. This chemical substance is the one responsible for the many health benefits of ginseng.

The types of Ginseng are:

1. PANAX GINSENG. This type of ginseng is also known as Asian ginseng. It is very rich in ginsenosides which proves that it is included among the types of true ginseng.

2. PANAX QUINQUEFOLIUS. This ginseng has an effective adaptogenic property. It is otherwise known as American ginseng. This herb is also considered as a true ginseng.

3. ELEUTHEROCOCCUS SENTICOSUS. The other name for this herb is Siberian ginseng. However, it is not considered as a true ginseng because it does not contain ginsenosides but eleutherosides. Also, ginseng has a fleshy root while this herb has a woody one. Despite their differences, Siberian ginseng also has similar effects to true ginseng herbs. It has an adaptogenic property which can effectively improve the overall health of the individual.

As mentioned above, ginseng has many benefits to human health. These include:

1. IMMUNE SYSTEM BOOSTER. Ginseng contains several vitamins and minerals which can be helpful in improving the immune system as well as the overall health of the individual. Studies have shown that ginseng has an ample amount of Vitamin C which can help maintain the health and strength of the body’s immune system. As a result, ginseng can effectively improve health especially those who are one the recovery PHASE of an illness.

2. LOWERS BLOOD GLUCOSE. Asian ginseng is noted for its potential ability to help regulate blood sugar levels. This is made possible because of its action in the stomach and intestine to control the absorption of glucose from the diet. In this connection, health experts highly recommend that individuals under diabetic therapy must use ginseng with extra care because it might cause hypoglycemia or low level of sugar in the blood.

3. AFFECTS BLOOD PRESSURE. Ginseng can produce an effect to the blood pressure of the individual, either high or low blood pressure. Depending on the dosage and the person’s response, ginseng can effectively maintain blood pressure within it normal limits.

4. IMPROVES THE OVERALL STATE OF HEALTH. Many ginseng consumers have reported that they experience an increased sense of well – being with their regular use of such helpful herb. It is also commonly used for the improvement of one’s stamina and endurance in performing many mental and physical tasks.

Ginseng can be consumed raw. Others use dried roots of this herb. Supplements are also available in the form of tablets, extracts and teas. Ointments and creams are also formulated for topical administration. If you plan to use ginseng for a particular health indication, make sure to talk to your doctor first since ginseng can have significant effect to the body as mentioned above. This will greatly prevent adverse effects and interactions with other medications you are taking.

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Date: November 02, 2011 07:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What does GABA Do in the Brain?

GABA

GABA or Gamma Amino Butyric Acid is a neurotransmitter of the brain. It is considered to be the main inhibitory brain chemical among mammals. In ordinary terms, it significantly regulates the firing of impulses by the neurons. This chemical is naturally produced by the brain and generally acts as a balancer together with other neurotransmitters. This neurotransmitter has a key role in the regulation of nerve excitability all throughout the nervous system. It effectively maintains the equilibrium of the body and the brain in excitation status. Chemically speaking, GABA is classified as an amino acid. However, GABA is not a building block of protein like the other amino acids. This is the reason why in the medical field, GABA is rarely considered as an amino acid.

Moreover, GABA is the prime brain chemical responsible for the regulation of muscle tone among humans. In a disorder called Spastic Diplegia, the absorption of GABA into the muscles is weakened because of damage nervous tissues and cells. This would significantly lead to hypertonic muscles in which the muscles will experience spasms and can not anymore recognize and process the neurotransmitter GABA. On the other hand, GABA in insects acts as both inhibitory and excitatory neurotransmitter.

The Brain

As mentioned above, GABA is an inhibitory neurochemical. It functions at the inhibitory synapses of the brain by attaching to receptor sites in the plasma membrane of both pre – and post – synaptic nerves. Once GABA has bind with the receptor sites, it will cause the ion channels to open and permit either the entry of chloride ion which has a negative charge or exit of potassium ion which has a positive charge. Potassium is the main electrolyte inside the cell. This opening of ion channels will then cause the cell to be either hyperpolarized or re – polarized.

During brain development, GABA also plays a significant role. It significantly controls the proliferation of brain progenitor cells and development of synapses as well as the differentiation and maturation of neurites. Furthermore, GABA is also responsible for the growth and development of embryonic and nerve stem cells. It also activates GABA receptors which lead to the halting of cell cycling in the S – PHASE. As a result, this will limit the growth of cell thus preventing abnormal growth and even malignancies.

If GABA is in inadequate level, muscle tone is disturbed making it always tensed and the mind will keep on working and working because there is no brain chemical to stop it. Therefore, GABA must be importantly maintained within normal limits.

GABA is naturally produced by nerve cells. However, GABA supplement is now available so that adequate amount of such brain chemical will be administered to the body as needed. GABA supplements can enhance the sleep onset and quality. It can also provide a relaxing feeling and reduce stress and muscle over – activity. Other theories also state that it can regulate mood and behavior thus promoting the total well – being of the person. Ongoing studies are being conducted to show more evidence on GABA’s effect with Human Growth Hormones.

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Date: September 20, 2011 11:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Acne Treatment of Different Skin Types

Not everyone has the same skin type, and if you have acne, then the treatment could be dependent on your skin type. Before discussing the different acne treatments available, therefore, it will be necessary to discuss the various skin types.

Skin types are graded in a number of ways, anything from 3 types to several. Here we shall discuss more than the normal three (oily, dry and normal) but instead look at seven.

1. Normal Skin

Normal skin looks evenly colored and textured, firm and smooth without larger pores. People with normal skin probably had mild acne when at high school, but cleared up fairly quickly during the teenage years without specialized treatment or scarring. Acne in this type of skin normally requires only mild topical treatment and a mild antibiotic face wash to keep the pores clean of dead skin cells.

Treatments designed to reduce sebum production could result in dry skin susceptible to environmental damage. What must be kept in mind is that the prime cause of acne is excessive production of skin oil, correctly known as sebum, becoming mixed with shed skin cells within the sebaceous pores and plugging them. When this plug gets infected with bacteria, the immune system leaps into action to produce puss through leucocytes attacking the bacteria, and inflammation designed to create temperature conditions alien to bacteria.

If you use treatments formulated to reduce sebum production in oily skin, then you might lose the natural skin oil needed to keep your skin waterproof and resistant to the pollution and chemical agents that can cause dermatitis.

2. Dry Skin

If you got through adolescence with few or no skin problems, and you have dry hair and your skin feels dry after washing, then you have dry skin. It is even more important with dry skin that you do not use sebum-reducing treatments, if you even get acne at all. Only the mildest acne treatments should be used if you have dry skin, thought is unlikely that you will get anything other the very mildest case if you really have dry skin.

Your skin can dry through age, so to be of a dry skin type, you should have suffered, or be suffering, these problems while you are 35 years old or under. After that age your skin tends to dry out naturally.

3. Oily Skin

This completes the trilogy of the classic skin types. Oily skin is associated with acne, and if your hair is oily, you tend to tan very easily rather than go red in the sun, and if oily make-ups, such as some foundations, tend to last only a short time, then you likely have oily skin.

You will also have suffered from acne as a teenager, and your skin will have a particular 'look'. It will often appear shiny, and will also seem to have a coarse texture with larger pores than most others seem to have. You will tend to get a lot of blackheads, not only as a teenager.

Oily skin is classically associated with acne, and it is for those with that skin type that classic treatments will be prescribed, such as antibiotics and Accutane.

Apart from these three skin types, there are others that have been defined involving a combination of these and also age.

Sensitive Skin

Sensitive skin is associated with broken blood vessels beneath the surface of the skin, and such skin types should be treated very carefully. If creams or lotions are applied to sensitive skin they should be rubbed in very gently as it could cause bruising.

Sensitive skin is no more susceptible to acne than most other skin types although significantly less so than oily skin. For that reason, treatments for sensitive skin should be similar to that for dry skin or in most cases normal skin.

Combination skin

Combination skin has an oily zone across the forehead, and down the nose and chin, the other areas of the face being normal or dry. Such skin can also be oily along the jaw line and normal to dry everywhere else. In such cases aggressive acne treatment might be necessary in the oily zones, and more mild treatments used in the areas which are normal.

There are three other classes or skin type based upon age or condition, one being mature skin and other ailing skin and the final type, surprise, surprise, being known as acne skin. Ailing skin is caused by skin conditions other than acne, and you should get the advice of a dermatologist if you believe you have this type of skin. Mature skin on the other hand is natural and occurs with age: the skin becomes slack and loose due to a slowing down of cell growth which causes the skin to lose elasticity. There is no cure for this type of skin other than cosmetic surgery, and it is rarely affected by acne.

Acne Skin

Acne skin is normally oily and associated with blackheads, pimples and spots. It is not normally applied to serious acne conditions, being mostly associated with skin which is generally 'spotty', as opposed to mostly clear. It is debatable whether acne skin is any different from oily skin which also tends to be covered with spots and pimples, and the treatments for acne skin are no different to those for oily skin: these are Accutane, antibiotics and topical treatments such as face washes and scrubs.

If you have acne skin you must be careful about the type of cosmetics and face cleansers you use, since either could aggravate your condition. This is not restricted only to those with oily skins of course, since everyone should be aware of the effect of cosmetics and face cleansers on their skin but it is more significant with those who suffer from acne. Cosmetics cannot cause acne, but they can help to aggravate infections which have already occurred.

Although most focus is placed on those with oily skins which are more susceptible to acne, people with any type of skin should consider carefully the types of cosmetic and cleansers which they use. Contrary to what you may have heard or read, acne has nothing to do with your diet - eating fatty foods or chocolates do not cause acne, which is caused only through production of excess sebum, or skin oil, by the sebaceous glands.

Irrespective of your skin type your physician will determine the best treatment that is appropriate for your particular case of acne. This may be different for individuals and may or may not change according to skin type. Antiseptic face washes or scrubs may be appropriate for some acne cases, Accutane might be the best treatment for others, while a course of internal antibiotics such as tetracyclines may be deemed appropriate for yet other cases.

Treating acne has three distinct PHASEs:

1. Removal of the blackheads and lesions. The removal of lesions can also involve a degree of scar removal, although that is another topic. Black heads, whiteheads and other papules can be treated by the use of facial cleansers and scrubs. They should not be squeezed since the puss inside them could be forced deeper into the skin and so lead to a more generalized infection.

2. Treatment of the bacterial infection. The typical symptoms of acne, the papules, whiteheads and blackheads, are caused by bacterial infection of the plug of sebum and dead skin cells within the sebaceous follicles. The general treatment for such infections is antibiotics, both topically and internally. Tetracycline has already been mentioned as a common internal antibiotic, and several forms of antibiotics are used in facial scrubs of which peroxides and benzoates may perhaps be rather severe for dry and sensitive skins.

3. The third PHASE is treatment of the causes of excessive sebum production. This is generally not entirely treatable since it is predominantly due to excessive hormonal activity at certain times of your life such as puberty, menstruation, pregnancy and menopause. However, your physician may offer treatments such as the contraceptive pill which should be used with care.

Other treatments include agents that aid desquamation, so preventing the irregular shedding of skin cells that lead to the mixture of sebum and dead skin cells that form the plug that is so easily affected by bacterial infection.

Together these three stages of acne treatment can, if not prevent the condition, certainly reduce its extent and have less of an effect on your skin, particularly if you are the off the oily skin type. Doctors will take your skin type into consideration when determining the best acne treatment for you, although all generally this will only be with respect to topical treatments: treatments that are applied to the surface of your skin.

There are also a number of herbal treatments which are used in the treatment of various stages of acne, and many sufferers find these equally as effective as the more traditional forms of topical applications as prescribed by physicians. However given that the treatment you use is safe according to your physician, any that works for you is the acne treatment that you should likely use, irrespective of your skin type.

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Date: August 15, 2011 06:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Are The Symptoms Of Magnesium Deficiency?

Magnesium is a chemical element and the seventh most abundant element in the crust of the Earth and is third most being dissolved in seawater. In the human body, it is the 11th most abundant by mass. Its ions are essential and play a major role in all living things through its ability to manipulate important biological polyphosphate compounds and most familiar of which is DNA. It is important in over 350 needed biochemical reactions in the body. Digestion, energy production, the function of muscle, formation of bone, creation of new cells, activation of B vitamins, relaxation of muscles, and also aids in the proper functioning of major parts of the body like heart, kidneys, brain and nervous system.

Magnesium deficiency is a state of the body where in dietary magnesium is below acceptable levels because of poor intake and can result to numerous symptoms and diseases. Magnesium deficiency is more common than most people think. However, these can usually be remedied by an uptake of magnesium in diet or through supplementation. In sever case though, intravenous remedies may be required. The initial symptoms of magnesium deficiency are more often than not subtle. Magnesium is stored by our body in its tissues, so pain in the muscles, cramps and some “twitches” are most commonly the first tell tale signs. Moving on down the list migraine, insomnia, or headaches are also most common of magnesium deficiency symptoms. Magnesium deficiency not only exists but is common.

Low Energy and Weakness

Magnesium has a key role in regulating how well our body processes the conversion of food into usable energy. Metabolism of carbohydrates and fats needs a number of magnesium-dependent chemical reactions. Some studies have found that during a low-magnesium PHASE of the body we use up more oxygen during physical activities. Our heart rates will increase by an additional 10 beats per minute. Inadequate magnesium has long been associated with a need for increased oxygen during strenuous activities and people who routinely complain of low energy should benefit from magnesium supplementation. Our muscles only can be pushed as far as its nutrition will allow, in other words if we lack magnesium to help lessen the need of oxygen all throughout our bodies then we should have an overall increase of energy and lessen the feeling of weakness since oxygen equals energy for our muscles, we need to help lessen our muscles need for oxygen to make it function more efficiently.

Weakening of the Bones

Some studies have found that Magnesium is perhaps, the most important single element to promote the health of our bones. For so long calcium was considered the foremost mineral in preventing Osteoporosis, however new research has proven that supplementing with magnesium is equally important. Magnesium comprises a percent of the human bones mineral make up. Bone mineral metabolism and matrix are both influenced by magnesium and allows are body to assimilate calcium easier. In essence it helps calcium to be absorbed by the bones more easily.

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Date: March 30, 2011 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Herbs and Prunes Help with Constipation

Herbs and Prunes as a natural laxative

Herbs and Prunes must be the best digestive formula out there. It contains a select combination of herbs whose laxative properties are tried and tested for decades, namely: senna leaf, Chinese rhubarb root, Chinese asparagus, beet leaf, buckthorn bark, cabbage leaf, cascara sagrada bark, celery leaf, cranberry fruit, Culver’s root, parsley leaf, spinach leaf, and prune fruit. In addition to their long-standing association with alternative medicine, medical research has pointed to their active ingredients that are purgative in nature. These herbs not only relieve digestive problems such as constipation and indigestion but also cleanse the gastrointestinal tract, effectively disposing of toxins.

Induces Bowel Movement

There are several factors that may give rise to constipation, but in most cases it results from withholding bowel movement far longer than what is considered normal. In general, a healthy individual is expected to discharge fecal matter from the bowels at least once a day although it may vary from person to person. The rectum sends messages to the brain every time the final PHASE of digestion is about to take place, and not responding to these messages leads to reversing the direction of the feces, which are temporarily stored in the colon. However, the colon is not able to reduce the pressure the feces produce for long periods of time, leading to constipation. The unique formulation of Herbs and Prunes relaxes the intestinal walls and softens the stools, making it much easier to evacuate the bowels.

Alleviates Abdominal Pains

The phytochemicals that are considered the active ingredients of Herbs and Prunes include anthraquinones, such as senna glycosides, sorbitol, and isatin, such as dihydrophenylisatin, among others. These organic compounds are reputed for their laxative properties that soothe the muscles tissues within the intestinal walls and influence the releases of chemicals that sensitive the digestive tract to pain. Irregular bowel movement causes what we refer to as stomach pains, and more often than not the foods that we eat influences regularity. A balanced diet is named so because it promotes digestion as well as gives us the nutrients our body needs in right amounts. Herbs and Prunes works on the principle of supplying our body with all-natural, plant-based dietary fiber and phytochemicals that restores normal digestion.

Detoxifies the Digestive Tract

Herbs and Prunes comprises a significant fraction of both soluble and insoluble fiber that are guaranteed to wash away toxins when ingested with ample amounts of liquids. As diet significantly influences human health, it is not surprising that the digestive system may be rendered susceptible to unhealthy foods. The alimentary canal is our first line of defense against toxins that the foods we eat produce. Plant-based foods that contain fiber remove by-products of digestion that otherwise accumulate in the bowels. In conjunction with phytochemicals, fiber is known to reach parts of the alimentary canal that play host to harmful microorganisms, the reason why plant-derived medications are often the cure to many diseases of the digestive system.

Herbs and Prunes

It is always recommended to keep a herbs and prunes formula on hand when irregularity hits. Grab yourself a bottle today!

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Date: July 14, 2010 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Glutathion, Antioxidants, And The Body

Glutathione is a simple protein that consists of three amino acids. These amino acids include glutamic acid, cysteine, and glycine. Due to the chemical nature of sulphur-containing cysteine, glutathione is able to effortlessly donate electrons. This ability is the reason why it has powerful antioxidant properties. Intracellular glutathione status is a sensitive indicator of cellular health and of the cell’s ability to resist toxic challenges.

Glutathione is an important water-PHASE antioxidant that is an essential component in the glutathione peroxidase system. Glutathione peroxidase enzymes are crucial for detoxifying peroxides including hydrogen peroxide, which is generated within cellular membranes and lipid-dense areas of the cell, especially the mitochondrial membrane. Severe glutathione depletion often leads to cell death, while experimental glutathione depletion has been found to induce cellular apoptosis.

A cellular level of glutathione depletion seems to cause extensive damage to the mitochondria. Depletion of mitochondrial glutathione may, in fact, be the ultimate factor that determines a cell’s vulnerability to oxidative(free radical) attack. The mitochondria is the most crucial place for glutathione presence, as the cascade of oxidation-reduction reactions complete the final steps in respiration take place here. Throughout this process, which is called oxidative phophorylation, electrons invariably escape and react with the ambient oxygen in order to generate toxic free radicals. It has been estimated that 2% to 5% of the electrons that enter the mitochondria are converted into reactive oxygen species that generate considerable oxidative stress for the cell. These free radicals cause an immediate threat to other cellular components, such as the DNA, enzymes, structural proteins, and lipids.

The cumulative damage that is caused by oxygen and other free radical species is now determined to be the principal contributor to the degenerative disease process and the progressive loss of organ function that is commonly recognized as aging. Because of this, the cell is constantly challenged to destroy these free radicals before they can inflict any lasting damage. Minimizing oxidative attacks may actually be the ultimate challenge of being alive. Because of this, the reducing power of glutathione is of huge important to the cell.

Glutathione is important for helping to regenerate other antioxidants that are depleted from their constant work to fight off free radical challenges. Regeneration that is glutathione-induced may be the mechanism that is actually used by the cell in order to conserve lipid-PHASE antioxidants, vitamin A, vitamin E, and the carotenoids. It has been confirmed by recent investigations that dietary vitamin C can actually protect us against tissue damage that results from glutathione depletion.

Additionally, supplementation with glutathione or its precursors can also quickly replenish any vitamin C deficiencies. Because of this, glutathione and ascorbic acid, both of which are pre-eminent cellular antioxidants, are tightly linked, as glutathione can conserve vitamin C and vitamin C can conserve glutathione. When they are both present, these two antioxidants protect the entire spectrum of biomolecules that are found within the cell, as well as facilitate the cell’s best performance. It has been said that the glutathione status of a cell may be the most accurate single indicator of the health of the cell. This means that as glutathione levels go, the health of the cell will go as well.

Glutathione is available in capsule or tablet form at your local or internet health food store. Always choose name brands to ensure quality and purity of the glutathione supplement you choose to purchase for consumption.

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Date: May 17, 2010 10:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Antioxidants and your health

There is an impressive amount of scientific evidence supporting the health benefits of supplementing with a wide variety of antioxidants. Consequently, there are many health practitioners who have begun to recommend high dietary intakes of these crucial nutrients in order to prevent against oxidative stress. It was anticipated over two decades ago by leading researchers that high-dose supplementation with antioxidants is developing a significant role in the prevention and treatment of a lot of today’s common illnesses. It should be noted that antioxidants do not work in isolation. When an antioxidant neutralizes a free radical, it, itself, is oxidized and must be regenerated by another antioxidant before it can be used again. Because of this, it is crucial to supplement with a wide variety of antioxidants, in order to reflect what actually occurs in nature.

Vitamin C, an aqueous-PHASE antioxidant, is the main guard against oxidative attack in the extra-cellular matrix, as well as within the cytoplasm of the cell. Vitamin C happens to be a substrate for eight different enzyme systems that are involved in various cellular functions. Among these functions are collagen synthesis, ATP synthesis in the mitochondria, and hormone biosynthesis. Its main antioxidant partners are vitamin E and beta carotene, both of which help to regenerate vitamin C.

Of all the antioxidants, it seems as if vitamin E offers the greatest protection against heart disease because of its ability to protect the cardiovascular system from oxidative damage. It is lipid-soluble, making it an important component of the cell membrane, where it works to protect the cell against lipid peroxidation and control oxidation-induced inflammatory events. Recently, the gamma tocopherol form of vitamin E has shown a great deal of promise in its ability to reduce the risk of several oxidative stress related disease.

Beta-carotene is a member of a diverse group of photosynthetic pigments. It plays a huge role in human nutrition. As an antioxidant, it possesses a double-bond structure that allows it to react effectively with single oxygen radicals, absorbing and diffusing their energy. Beta-carotene also acts as a precursor for vitamin A by supplying a portion of the body’s requirement for the vitamin. This act alone plays a central role in the chemistry of vision. Beta-carotene and vitamin A both prevent the oxidation of cholesterol, reduce oxidative damage to DNA, and disable oxygen free radicals that are produced by exposure to sunlight and air pollution. These antioxidants are also involved in the activation of gene expression and the control of cell differentiation.

When combined together, vitamin C, vitamin E, and beta-carotene produce and important antioxidant trio that plays a huge role in fighting oxidative and inflammatory events. There are several other antioxidants that should be noted due to their ability to work synergistically with the vitamin C, vitamin E, and beta-carotene trio. These include vitamin A, alpha-lipoic acid, lycopene, coenzyme Q10, and the antioxidant mineral, selenium. In order to determine whether a nutrient provides antioxidant support, scientists question whether the product contains vitamin C, vitamin E, vitamin A, beta-carotene, alpha-lipoic acid, lycopene, coenzyme Q10, and selenium and to what strength these vitamins and minerals are per serving.

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Date: September 28, 2009 02:35 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Probiotic 10 - 25 and 50 Billion

Protiotic 10

Probiotics play an important role in human health. Aside from their support of the digestive system, friendly flora are involved in countless biological actions that significantly affect the quality of life.

Unfortunately, the industry has been without a line of truly “allergen-free” probiotics; a void that has proven problematic for allergen-sensitive individuals wishing to complete their supplement regimen with probiotics. Additionally, many probiotic formulas claiming to be allergen-free are not 100% vegetarian/vegan. Trace amounts of dairy media from which they were cultured is often retained, while others may be encapsulated using beef gelatin or other animal-derived ingredients. We don’t think something of such great importance should come with such limitations. NOW® Probiotic-10™ is a unique blend of ten probiotic strains delivering either 25 or 50 billion beneficial organisms, respectfully, providing nutritional support for the maintenance of a healthy digestive system.*

Allergen-free, Dairy-free

Today’s probiotics are grown mainly in dairy media. And while some manufacturers assure dairy-free status, third-party testing often proves otherwise.

The bacteria strains in NOW® Probiotic-10 are grown on a vegetarian media. This ensures the absence of dairy and other allergens, while providing a high digestive tolerance.

Superior Potency & Quality

Extreme care is taken throughout each manufacturing PHASE of NOW® Probiotic-10™. Its probiotic strains are cultured with non-GMO media, and packed in amber glass bottles for superior protection. NOW guarantees full potency (25 or 50 billion live organism) through each product’s “Best By” date.

Vegetarian/Vegan Assurance

From initial fermentation to final encapsulation, NOW guarantees that Probiotic-10™ is 100% vegetarian/vegan.

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Date: February 21, 2009 12:33 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Migraines

Migraines are severe, throbbing headaches that may or may not be accompanied by nausea, possibly with visual disturbances and other symptoms. Migraine incidences have increased by 50 percent within the last twenty years, with an estimated 25 to 30 million people suffering from them in the United States. Three out of four of these 25 to 30 million are women, with up to 24 percent of women experiencing at least one migraine in their lives and only 12 percent of men getting migraines. Migraine headaches are one of the most severe types of headache.

Research has described migraines as vascular headaches, as they involved excessive dilation or contraction of the brain’s blood vessels. Current research, however, gives other clues. The inflammation involved in migraines is most noticeable in the meninges, which surround the brain and the spinal cord. However, the inflammation of the meninges is not what leads to the pain of migraine, but instead abnormal nerve activity. Stimulation of the trigeminal nerve, which goes from the brain to the head and face, triggers the release of substances that are known as calcitonin gene-related peptides. These induce inflammation and send messages to pain receptors in the meninges. Some researches even liken migraines to meningitis in some ways, as the symptoms are very similar. However, meningitis is caused by viral or bacterial infection.

Migraines can occur anywhere from once a week to once or twice a year, often running in families. One factor that may contribute to the higher incidence of migraine in women may be fluctuations in the level of the hormone estrogen, as women typically get migraines around the time of menstruation, when estrogen levels are low. Most often, migraines occur in people between the ages of twenty and thirty-five, seeming to decline with age. Children can also suffer from migraines, with pain tending to be more diffuse, rather than localized. Migraines can first show up in childhood as colic, periodic abdominal pain, vomiting, dizziness, and severe motion sickness, rather than as headaches.

There are typically five PHASEs in a migraine. The first PHASE beings a day or so before the onset of a headache, as changes in mood, problems with memory, an alteration in one or all of the five senses, and speech problems occur. Secondly, some people will see flashes or patterns of light and experience numbness of the hands and mouth just before the headache. This is called an aura, and is a common sign of a classic migraine.

Those migraines that occur without auras are called common migraines. The third PHASE occurs when the headache starts with a severe, throbbing pain occurring on one or both sides of the head and can also move from side to side. Nausea can also set in this PHASE, along with tenderness in the neck and scalp, sensitivity to light, and possibly immobilization due to pain. The fourth PHASE occurs when the headache dissipates, although nausea may linger. During the fifth PHASE, the person may feel tired and lethargic, simply wanting to sleep.

A variety of things can trigger a migraine in an individual who is susceptible, including allergies, constipation, stress, liver malfunction, too much or too little sleep, emotional changes, hormonal changes, sun glare, flashing lights, lack of exercise, and changes in barometric pressure. Dental problems and low blood sugar can also be factors, while other underlying causes such as genetic factors, chemical imbalances in the brain, poor nutrition, and the overuse of painkillers can cause an individual to be susceptible to migraines. Block Migraines with vitamins and herbs.

The following nutrients are recommended for preventing and dealing with migraines: calcium, magnesium, coenzyme Q10, DMG, DLPA, essential fatty acid complex, 5-HTP, a multivitamin and mineral complex, rutin, vitamin B complex, garlic, quercetin, taurine, vitamin C with bioflavonoids, cordyceps, feverfew, ginkgo biloba, cayeene, chamomile, fumitory, ginger, peppermint, rosemary, valerian, willow bark, and wormwood.

If you are experiencing migraines, consult your doctor before starting vitamin supplements. Vitamin supplements are natural and feed the body to make it stronger and capable of fighting the diseases it may come up against, but medications prescribed by your doctor can conflict with certain vitamins and herbs and a doctors consultation is needed when taken with medications. A source of natural vitamins are available at your local or internet health food store.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Natural vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

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Date: April 10, 2008 01:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Prevention and Treatment or Prostate Cancer

Last week I shared with you the controversy surrounding the use of PSA screening to determine the status of the prostate. There are many doctors who do not believe that using PSA is accurate enough to rely on for determining whether or not a high PSA indicates prostate cancer. Many men, who have a high PSA, after more detailed examination, did not have cancer and men with a low PSA did have cancer. Some physicians do not believe that the current methods of diagnosing prostate disorders are saving lives. Also, there is a group of physicians nationwide that strongly believe the best treatment is no treatment but rather a “watch and wait” approach. Prostate cancer usually is slow growing and more than 70% of men who develop it are over 65.

The older a man is, the more likely he is to die of some other condition before his prostate cancer becomes a real threat. To reiterate, the American Cancer Society states, “at this time watchful waiting is a reasonable option for some men with slow growing cancers because it is not known whether active treatment such as surgery, radiation therapy or hormone therapy prolongs survival”. So what action can be taken? While prostate enlargement (BPH) is not related to prostate cancer, it can elevate PSA scores and can cause symptoms in 50% of men by age 80 and nearly all will show signs of BPH by age 85.

If you have early symptoms of BPH such as frequency of urination, a burning feeling after urination and the caliber of stream that isn’t what it used to be, getting up several times through the night and low back pain, taking a good prostate support formula will be your best treatment and prevention. Most men will notice a remarkable improvement within a few weeks. A good prostate support formula will provide relief for 80-90% of all men from these annoying symptoms.

But what about prostate cancer?

The best cure for prostate cancer is prevention. I’ll give you a complete supplement program for prevention but first what about PSA testing? “I don’t believe in screening for something when it’s too late. By the time cancer develops a positive mammography or a true high PSA are likely too late, or if fortunate, that particular cancer will not be a problem. It makes far more sense to prevent the problem in the first place. And there is clear data, prevention is possible”. Dr. Robert J. Rowen, MD, Second Opinion, Soundview Communications. My recommendation, based on research of several scientific studies, includes various nutritional supplements and herbal extracts.

Following are several very important studies that all men should be aware of. In 1966 Dr. Larry Clark of the University of Arizona published startling data suggesting that prostate cancer could be reduced by as much as an amazing 60% by supplemental yeast derived selenium, 200 mcg per day. Selenium is a powerful antioxidant and participates in key and crucial detoxification and free radical scavenging enzymes (80-90% of all disease is caused by free radical damage and inflammation).

Selenium is one of a number of antioxidants to prevent this free radical damage; In 1999 a New Zealand study published in the British Journal of Cancer documented a 40% lower incident of prostate cancer in men with the highest levels of omega-3 fatty acids EPA and DHA in their blood. These findings have been confirmed in other omega-3 fatty acid studies. Conversely, another published report documents a high level of omega-6 to omega-3 fatty acids in invasive prostate tissue samples. Taken together with recent reports on high levels of omega-6 fatty acids (soy, sunflower, safflower, peanut, corn and most vegetable oils) linked to breast cancer, a common thread emerges. The American diet is overwhelmed with omega-6 oils.

Excessive use of omega-6 fatty acids are cancer causing and also cause inflammation. Trans fatty acids from hydrogenated oils seriously add to the problem. There are other nutrients that have shown to reduce prostate-cancer risk. Vitamin E and lycopene have also shown to prevent prostate cancer. Lycopene is commonly found in tomatoes, especially cooked tomatoes. If you like spaghetti sauce or salsa, this is a great way to fight prostate cancer. While vitamin E, selenium, lycopene and omega-3 fatty acids are all great prostate supporting nutrients, through research I found a much more powerful combination of food grade molecules that can prevent and treat cancer.

Extensive research in the last few years has revealed that regular consumption of certain fruits and vegetables can reduce the risk of prostate cancer. Fruits and vegetables having the highest degree of prostate cancer protection are the following: grapes (resveratrol), garlic, tomatoes, hot peppers, turmeric (curcumin), ginger, berries, milk thistle, cloves and fennel. These foods are protective because they are extremely active and excellent antioxidants. My favorite is turmeric (curcumin) because not only is it an antioxidant, it is also an anti-inflammatory agent. When it has this dual effect it is many times more potent than other types of food. In the United States there is 30 times more prostate cancers diagnosed than there are in India where turmeric is consumed liberally in most of the Indian dishes. Cancer does not begin shortly before it’s diagnosed.

The origin of cancer may be years or decades in the process before it is even diagnosed as such. It is a multi-step process that goes through various PHASEs such as cellular damage and transformation and culminates in the acquisition of invasive potential angiogenic properties and establishment of metastatic lesions. This process, and probably rightly so for all cancers, can be activated by any one of the various environmental carcinogens (cancer causing); all forms of tobacco products, industrial emissions, gasoline vapors, inflammatory agents, food coloring and preservatives, excessive UV rays, alcohol, hair dyes, cleaning products and drugs.

The multi-step process of these cancer causing compounds progress in three stages; tumor initiation, promotion and progression PHASEs. A powerful antioxidant/anti-inflammatory can prevent most if not all of the damaging effects when taken on a daily basis. Several population based studies indicate that people in Southeast Asian countries have a much lower risk of acquiring colon, gastrointestinal, prostate, breast and other cancers when compared to their western counterparts. It is very likely that constituents of their diet such as garlic, ginger, turmeric, onion, tomatoes, cruciferous vegetables, chili’s and green tea play an important role in their ability to avoid these cancers.

These foods, or key active extracts from these foods, are known to block the NF-kB activation process. Also, several phytochemicals such as curcumin, resveratrol and green tea catechins have been shown to suppress AP-1. Several chemopreventative phytochemicals including curcumin, resveratrol and green tea have been recently shown to be powerful inhibitors of several growth factor receptors including EGFR. Curcumin also possesses the capacity to inhibit the activation of the EGF-Receptor indicating that it has the potential to break the autocrine loops that are established in several advanced cancers.

Studies also suggest that curcumin, resveratrol and green tea can actually be used as safe, non-toxic treatments in drug resistant cancers. These natural phytochemicals (food grade) can help fight certain cancers thereby requiring a smaller dose of drug chemotherapy. They also can protect the body from the damages of drug chemotherapy and radiation. “This mini review presents evidence that chemopreventative agents, curcumin, green tea and resveratrol, can be used not just to prevent cancer but also to treat cancer. Because of their pharmacological safety, most chemopreventative agents can be used in combination with drug chemotherapeutic agents to enhance the affect at lower doses and thus minimize chemotherapy- induced toxicity. Because cancer is primarily a disease of old age, less toxic therapy is a major priority. This review reveals that molecular targets of chemopreventative agents are similar to those currently being used for the treatment of cancer. Tumor cells use multiple cell survival pathways to prevail and thus agents that can suppress multiple pathways have great potential for the treatment of cancer”1,2. Curcumin, resveratrol and green tea were as effective in preventing and treating certain cancers based on lab and animal studies. There have been approximately 20 human positive studies but much more needs to be done.

From the research that I have done, I am convinced sufficiently enough to take many of these compounds as a preventative of cancer. These compounds are completely safe and non-toxic even in high doses. What does one have to lose? Why not take the positive preventative measure? –Compliments of Terry Naturally

Ref: 1. Role of chemopreventaive agents in cancer therapy. Comprehensive Cancer Center Our Lady of Mercy Medical Center, New York Medical College, Bronx New York

2. Cytokine Research Section, Department of Bioimmuno Therapy, University of Texas, M.D Anderson Cancer Center, Houston Texas

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Date: February 09, 2008 10:43 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Benefits of Ascorbyl Palmitate A Fat-Soluble Form of Ascorbic Acid

The benefits of ascorbyl palmitate are due to the substance being a fat-soluble form of ascorbic acid which is otherwise known as vitamin C. Before discussing why being fat-soluble should be of benefit, let us first have a look at what vitamin C does for us and what its limitations are.

Most people know vitamin C as the vitamin that prevents us from getting scurvy, and that limes and other citrus fruits were given to sailors to prevent them from contracting this often fatal disease on long journeys. However, important though the protection it provides against scurvy is, there are many more important uses for this important vitamin. In fact some of them are closely connected to the symptoms of scurvy.

Among these are pains and swelling in the joints, and the loosening of teeth and hair loss. Scurvy is also associated with easy bruising and bleeding. All of these can be associated with loss of collagen, which is contained in connective tissues, bone and blood vessels. Collagen repairs and maintains cartilage, heals wounds and is essential for proper skin formation and the structure of ligaments, tendons, blood vessels, bones, hair and teeth. When we consider that one of the most important properties of vitamin C is the part it plays in the production of collagen in the body, then its effectiveness in alleviating the symptoms of scurvy is not difficult to understand.

Vitamin C is also a strong antioxidant that destroys free radicals that kill and severely damage body cells, and cause a large variety of undesirable conditions such as atherosclerosis and cancers, and also debilitating and painful inflammatory conditions such as arthritis. Many free radicals are formed in the body as by-products of our metabolism: the generation of energy from fats and blood glucose. Others are ingested in the form of cigarette smoke and other toxins, while yet other free radicals are caused by the effect of sunlight on our skins. Natural antioxidants such as vitamins A, C and E help to keep these free radicals under control and minimize their effect.

Another interesting property of vitamin C is in the synthesis of carnetine, a deficiency of which is also thought to contribute to scurvy. Carnetine is needed by the body to transport fat to the cellular mitochondria so that it can be converted to energy. Vitamin C is also believed to take part in the biochemistry that converts cholesterol to bile acids and so helps to maintain a healthy level of cholesterol in the blood.

The vitamin is therefore a very useful one for the body, but it has one fault. It is water soluble, and hence cannot be stored in the body but is expelled in the urine. Had it been fat soluble it could have been able to be stored in the body fats, in the same way that vitamins A and E are, and be available for use when required. Instead any excess that is not immediately used is lost, and a fresh intake of ascorbic acid necessary on a continuous basis.

Not only that, but it is only of use in areas of the body that the blood can reach. Fatty tissue is practically devoid of vitamin C, and many areas of the brain cannot be reached by substances that are insoluble in oils and fats. It also finds it difficult to penetrate the skin and the walls of body cells. This is where the benefits of ascorbyl palmitate are useful.

Ascorbyl palmitate is a fat-soluble form of vitamin C and possesses all of the attributes of ascorbic acid. It is more easily absorbed by the body and can be stored in the membranes of the cells until needed. It is also a powerful antioxidant, the same as vitamin C, and is frequently used to prevent the oxidation of vegetables oils, such as on potato chips and other oily snacks. It also takes part in the biochemistry of the production of collagen and connective tissues.

The usefulness of this substance comes from not only from its amphoteric nature, whereby it has one end that is water soluble and another that is fat soluble, but also by the fact that it is also amphipathic, meaning that it prefers neither one medium nor the other, and tends to collect at PHASE boundaries, between oil and water PHASEs. It is particularly effective in topical uses on the skin, because it is easily absorbed into the skin tissue, and more stable than some of the other forms of vitamin C. It is also believed to protect other fat soluble antioxidants such as vitamin E from oxidation, and also to help to protect blood cell membranes from free radical attack.

Although vitamin C is a very powerful vitamin, carrying out a multitude of tasks, ascorbyl palmitate has some advantages over it apart from the solubility difference. Its antioxidant properties are stronger than those of regular ascorbic acid and in fact rival those even of vitamin E, which it also helps to regenerate after its reaction with free radicals, and help to maintain a continuous supply of this powerful antioxidant.

It is also a chemically neutral form of the vitamin, and unlike regular ascorbic acid, does not cause inflammation of the tissues it comes into contact with. It can also reduce sunburn due to excessive exposure to UVB when applied to the skin, and is a very stable form of the vitamin. Ascorbyl palmitate also acts as an anti-inflammatory with certain conditions, such as psoriasis where topical application helped to reduce the extent of the lesions. In fact it appears to do most of what vitamin C does, but faster and with smaller doses.

So why is ascorbyl palmitate not used as the main form of vitamin C in supplements? The answer is money. Ascorbyl palmitate is considerably more expensive than regular vitamin C, and also normal ascorbic acid has some properties that the fat-soluble form does not have, such as its ability to rapidly pass through the body in the bloodstream.

However, it would make sense to take a supplement consisting of both forms of vitamin C, and so combine the best properties of each. Any vitamin C supplement that is designed for maximum effect on the body should contain at least 25% of ascorbyl palmitate, the balance being ascorbic acid. That is what to look for if you are to receive the combined benefits of both water and fat soluble vitamin C.

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Date: January 29, 2008 10:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Detox your Body with Wasabi Rhizome

The Wasabi rhizome, the underground fleshy stem of the wasabia japonica plant, is prized not only for its fiery flavour but also its effect in detoxifying the liver. However, make sure that you are getting the real McCoy since many restaurants in the USA do not use the genuine paste.

The wasabi is a plant of the cruciferous family, the same family as cabbage, broccoli, turnip, radish, horseradish and mustard, and is native to Japan and Korea and now grown on the Pacific coast of Canada. It grows best in temperate to cold climates, especially in mountainous areas where there are plenty of cold streams.

Anybody who regularly enjoys sashimi and sushi should be familiar with the wasabi rhizome, that green lump of paste lying on the side of the plate. It is hot and fiery, although not in the same way as the chilli pepper that is fiery on the tongue and in the mouth. This tends to affect the sinuses more, and leaves a sweetish taste once the initial heat has dissipated. However, it is not always what it should be.

The last comment there refers to the practise, especially in the USA, of using dyed common horseradish as wasabi paste, so be careful of that since the two are not equivalent in the health benefits they impart to your body. Although of the same family as the horseradish, and sometimes termed the Japanese horseradish, ordinary horseradish does not have the same health benefits as genuine wasabi, and does not contain the same active ingredients so do not confuse the two.

Real wasabi is normally used grated, and there are specific techniques that should be used to grate wasabi rhizomes to bring out the fullness of the flavour. True grated wasabi should be of a natural pale greenish color rather than the brighter green normally associated with sushi restaurant wasabi.

Traditionally, wasabi rhizome is used as a condiment with sushi, although their leaves can also be used in salad dressings and or as a delicacy pickled in soy sauce or sake brine. The genuine vegetable is difficult to cultivate which explains why ordinary horseradish is dyed and used in its stead, and the vast majority of non-Japanese do not know the difference because it is likely to be all they have consumed under the name of wasabi. The health benefits of the genuine article, however, are considerable greater.

So that’s what it is, but what does it do? What are the health benefits of wasabi rhizomes and why are they considered to be so good for your liver? Wasabi rhizomes contain substances that are very effective in detoxifying you liver, and that are also very strong antioxidants that provide you with good overall health benefits in their capacity to destroy the free radicals created by the pollution of modern living.

The active antioxidants in the rhizome are precursors of isothiocyanates, which are known as phytochemicals. These are chemicals that can protect or prevent diseases through its antioxidant properties. The term ‘precursor’ means that the isothiocyanates are synthesized by your body from the nutrients contained in the wasabi rhizome. Other examples of phytochemicals that you may have heard of are carotenoids, flavonoids and polyphenols that also possess antioxidant properties.

Other antioxidants are vitamins A and E, which is why these are used in anti-wrinkle creams, since their anti-oxidant effect helps to prevent the free radicals destroying the skin cells in the dermis and epidermis that leads to the wrinkles associated with aging. Wasabi is equally effective as an antioxidant, although it has other properties that are important to your liver.

The liver is your body’s chemical plant. That is where most of the chemical reactions take place that are essential for life. If your liver is unhealthy you can develop diseases such as hepatitis and cirrhosis, and a healthy liver is essential for life let alone a healthy life. Wasabi helps to detoxify and clean out your liver.

Apart from creating the wide variety of enzymes needed to process your food, and controlling the vast majority of the biochemistry of your body, your liver is also your detoxification plant that coverts toxins into biodegradable molecules that your waste disposal system can evacuate without harm. This occurs in two PHASEs.

PHASE I coverts the toxin to a form that your body can further process (the bioactive form), and PHASE II breaks it down into a form that your kidneys can handle and eject it in your urine. Isothiocyanates are involved in the production of the enzymes that enable the chemical reactions of PHASE II to proceed. They allow your body to cleanse itself of toxins, and without this process you would be less healthy and more prone to cancers and other undesirable conditions and diseases in your body.

It is becoming more important in this modern age with its increasing natural and synthetic pollution that your liver is working at peak efficiency. Your liver is equally as important to you as your heart and brain, and without it you cannot survive. Wasabi also contains glucosinolates that help the isothiocyanates to induce the production of PHASE II enzymes, and it is general believed that eating this tuber cab help protect you against stomach, colon and breast cancers as well as help your cardiovascular system and blood clotting.

An interesting fact is how wasabi rhizome came to be traditionally served with raw fish. The isothiocyanates precursors, and the glucosinolates that wasabi also contains, apparently help to destroy the bacteria associated with raw fish, and help prevent disease and illness. It was likely found healthier to include a dollop of this green paste with your sushi than not, and so the use of common horseradish might be somewhat questionable if it has less of an effect.

Make sure, therefore, that your have the real thing, and apart from any specific health considerations associated with eating raw fish, you are best advised to take it as a supplement to help Detox your liver rather than visit sushi bars for your consumption. It will also help your wallet!

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Date: January 22, 2008 04:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: You Should Say: Please Pass the Broccoli, Not I’ll Pass

'Please pass the broccoli': not something that many mothers hear from their children. In fact, not many children appear to like any green vegetables let alone broccoli. This is not important at such a young age, but there comes a time when the health benefits that broccoli brings become almost essential to your good health and well being. Parents are right, but your children won’t believe you.

Some say that the nutritional punch of broccoli is stronger than that of any other vegetable. Is this claim justified? Let’s have a look at the evidence and the facts and you can judge for yourself. First the ‘ordinary’ nutrients of broccoli: vitamin C (more than oranges) and A, folic acid and calcium and also lots and lots of fiber. However, this wonderful vegetable contains not only high levels of calcium, but is also the one of the richest vegetable sources of magnesium. Calcium needs magnesium in order to be properly incorporated into your bone structure, and so broccoli is a very important calcium/magnesium source for vegans that do not drink milk or eat any other dairy products.

It is also rich in protein, containing 3% by weight and is also rich in iron. It is therefore an important part of the diet of women during menstruation when iron is important to enable the blood to maintain its proper erythrocyte levels. A deficiency of iron in the diet of women can lead to anemia and render them more susceptible to infection. However, it is more than just iron that renders this vegetable an important part of the female diet. Broccoli has been established to be of major importance in preventing cancer.

It is likely the most potent anti-cancer vegetable in your diet, and it has been established over 20 years of study that broccoli can help to prevent cancers of the breast and the cervix. The indoles that it contains prevent estrogens from promoting tumor growth, and it also contains beta-carotene, a strong antioxidant that destroys the free radicals that can also cause cancer. However, there is more to broccoli than just that.

Broccoli contains the highest concentration of sulforaphane of all the cruciferous vegetables that include Brussels sprouts, cabbage, cauliflower, rocket and turnip, amongst many others. When you chew broccoli, the glucosinolate glucoraphan is converted to sulforaphane, not by the enzymes in your saliva, but by the actual physical damage done to the plant by the act of chewing. It could likely also be generated by hitting it with a hammer! It is glucosinolates that provide the slightly bitter taste many people experience when they eat vegetables such as brussels sprouts and broccoli, and that likely renders them somewhat unattractive to children!

Sulforaphane is an isothiocyanate containing the NCS functional group, and is actually bound loosely to the sugar as sulforaphane glucosinolate. It is the loose binding that allows it be released on chewing. Broccoli sprouts are its richest source, and it is a strong antioxidant which is why it is so effective in reducing the possibility of certain cancers.

When fighting cancers, your body produces PHASE-II enzymes, and since sulforaphane induces these enzymes, it stops the carcinogens before they can damage your DNA. This is achieved through the enhancement of the transcription of the proteins that suppress the tumors. In layman’s terms, it is the generation of tumor suppressant proteins from DNA that kills off the tumors before they can destroy the DNA.

There is even more however. Indoles have already been mentioned, and those in question are predominantly indole-3-carbinol (I3C) and 3,3-diindolylmethane (DIM). The latter is generated from the digestion of the former and possesses very potent anti-cancer properties. However, this indole can affect your health in ways other than just as an anti-cancer agent. It can modulate the immune system in a way that renders it suitable for the treatment of a number of viral infections, and is also believed to be a possible answer to the problem of bacteria that have become resistant to antibiotics. It appears to operate synergistically with Interferon-Gamma, a cytokine that helps to prevent viruses from replicating within the cells of the body, to strengthen the MHC-I Complex, a part of the human genome that supports the immune response to viral attacks.

To put it plainly, broccoli can aid your resistance not only to certain cancers, but also to attack by viruses and some bacteria. It is not only cancers of the cervix and breast that broccoli can help to prevent, but also of the lung, prostate, larynx and bladder. I3C also helps to support the function of your liver in detoxifying your blood as well as supporting the cellular reproduction without which your body could not maintain itself after damage.

Broccoli is therefore an important vegetable to men as well as to women, not only for its anti-cancer properties, but also as a general antioxidant and consequent free radical scavenging properties. Its high fiber content is equally split between soluble and insoluble vegetable fiber, and so meets your dietary needs of both types.

Cruciferous vegetables such as broccoli have been singled out by health organizations the world over as essential to your diet, and you should eat them regularly. Once daily would be good, but more is recommended if possible. As stated at the start, strong tasting vegetables containing glucosinolates might not be attractive to children and younger people, but their phytochemical content (the foresaid indoles and isothiocyanates) render them very potent antioxidants and anti-cancer foods.

Taken in relation to other foods, an ounce of broccoli contains as much calcium as a glass of milk, more vitamin C than a similar weight of orange, and a medium floret has more fiber than one slice of bran bread. It is rich in vitamin A and of course there are the other antioxidants and anti-cancer phytochemicals already detailed.

There are many ways of cooking broccoli to maintain its nutritional content, but if you do not like broccoli, then there are supplements available. You can purchase pure broccoli extract or an extract from a mixture of cruciferous vegetables. The choice is yours, but of one thing there can be no doubt. Broccoli is the king of green vegetables, and the nutrients it contains are not available in any other vegetable in such a concentrated and easy to assimilate form.

Your mom was right: it's not just 'eat your veg', but 'eat your broccoli'. No nutritional advice could be better than that. “Pass the broccoli please mom!”

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Vitanet®, LLC

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Date: December 21, 2007 10:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How to Manage Migraines Naturally: Magnesium - Feverfew - Butterbur - Ginger

Before you can understand how to manage migraines naturally, it is necessary to understand exactly what they are and how certain treatments could work. It is not generally known that the word ‘migraine’ means ‘half the head’ because it frequently hurts only on the right or the left of the head of sufferer. Some people with migraines do feel pain on both sides at once, although this is not generally the case.

A migraine occurs in stages which are activated by fluctuations in the hormone content of the blood. The ‘aura’, when you see spots and flashing lights in front of your eyes, is the first stage of a migraine attack, and during this time the blood vessels in your neck and head are contracting. You could also find it difficult to concentrate and your fingers could feel cold. At this point they do not have the headache that starts when the blood vessels begin to dilate.

Rather than the contracted blood vessels slowly returning to normal, your hormones have an excessively strong reaction, and cause them to dilate rapidly and become much wider than they should be leading to a severe headache due to pressure on the nerves. Different hormones can be involves with each attack, and the range of effective natural treatments reflect this fact. During this period, your brain could swell slightly, your muscles can tense up and other things can happen to the chemical and hormonal balance of your body. That is why some herbal treatments work for some but not for others, and different people find different treatments effective for them. What works for you might not work for somebody else if their migraine has a different cause. Basically, though, migraines occur in two PHASEs, one being associated with an excess of hormones and the other with a shortage.

It is not easy to live with a migraine since it can be completely debilitating. Some just have a severe headache, while others are affected for days at a time. The headache can become before and after the onset of the shimmering lights and other optical effects that are generated by the brain. It would certainly be useful if those prone to migraines had one or more of the possible natural remedies to hand since there is rarely time to seek to seek professional medical help once the migraine begins, and through the use of natural remedies a potentially bad attack could be nipped in the bud, and at least its effect on you reduced.

MAGNESIUM

Magnesium is common in green leafy vegetables such as spinach and cabbage, whole grains, nuts and seeds. It is an essential mineral for human biochemistry, and is also needed with calcium for healthy bone development and maintenance.

Magnesium is a muscle relaxant, and relaxes the muscles of the blood vessels helping them to relax their dilatancy that cause the migraine pain. It is also useful to help the immune function, reduces blood pressure (by the same blood vessel relaxing mechanism) and also the rhythm of your heart. Magnesium therefore provides you with many health benefits, and though the western diet is not generally deficient in magnesium, some areas can be and a magnesium-containing supplement will not do you harm.

However, particularly high dose of magnesium can lead to nausea, diarrhea, low blood pressure and many other unpleasant side effects, so do not take more than the RDA (recommended daily allowance) in your supplement. Many studies have confirmed its effectiveness in reducing the symptoms of migraine, but not all studies have been successful. However, the condition is so debilitating to so many people, that it should be tried although not in excess. Make sure, however, that your doctor is informed since it could interfere with other medication you are taking for your migraine.

Riboflavin, vitamin B-2, is also believed to useful in reducing the duration and frequency of migraine attacks, working in much the same way as magnesium. It is known that there are many cases of people who suffer from vitamin B-2 deficiency also suffering from migraines, and a riboflavin supplement is also worth trying if you are a consistent victim of this condition.

FEVERFEW

Feverfew is the best known of the herbal remedies for migraine, and has been used for centuries in the treatment of fevers, headache, migraine and other painful conditions such as arthritis. The active ingredient is parthenolide, an anti-inflammatory that is also an anti-hyperalgesic, and that would explain its effect on reducing the pain. It also blocks lipolysaccharide-induced osteolysis by suppressing the activity of a eukaryotic transcription factor protein known as NF-kappaB that can cause a number of immune response problems, including inflammatory conditions such as arthritis, hence its use to relieve that condition.

Its effect on migraines could be explained by this activity in repressing the inflammatory response to certain stimuli that could be brought about by hormonal activity. Because it must be taken for a few weeks before the actual problem arises in order to be effective against it, feverfew is not effective to treat an existing attack, but to prevent future attacks. Double blind studies have proved its effectiveness in many tests, but not in all. However, if you take feverfew as a regular supplement in you diet, you might never have to try magnesium or vitamin B-2 supplements.

Some people swear by the leaves of feverfew, eating one per day which is easy way to take it. It is important, however, that you do so regularly, since it can take for up to 6 – 8 weeks for you to notice a reduction in your attacks. Don’t give up after 5 or 6 weeks, but continue, since the results will be well worth it. If you stop for a week or two you will have to start all over again. You might get a sore mouth and perhaps mouth ulcers to start with, but these will eventually go once your body is used to it.

You are probably best not to take if you are pregnant since it could cause you to abort. Otherwise, however, it has been shown to be effective in many severe cases. Feverfew is bitter, and can be used as a tea with other herbs, such as rosemary, lavender and sage. If you are taking warfarin, aspirin or other blood-thinning drugs, see your doctor first, and the same is true of NSAIDs (non-steroidal anti-inflammatory drugs). If you are taking these for arthritis, the feverfew itself might be more effective!

If you are taking feverfew as a supplement using commercially available dried leaf then the recommended dosage is around 125mg of the dried leaf. It should contain at least 0.2% of parthenolide (0.25mg/daily), although other studies have indicated that a total of 0.7 mg parthenolide a day should be taken (100mg at 0.7%). Parthenolide is unstable so don’t take it after its sell by or best by date.

BUTTERBUR

Butterbur is also useful in the treatment of migraines. The active ingredient here is petasin, a sesquiterpene ester that also has anti-inflammatory properties, all though it works in a different manner to feverfew. Here, it inhibits the activities of leukotriene generation in neutrophils and eosinophils, which indicates that it also possesses anti-allergenic properties that could help asthmatics that also suffer from migraines. It does not prevent the release of histamine, but does appear to reduce smooth muscle spasm.

You should never take the raw herb, only the extract, because it contains alkaloids that can harm you. The butterbur extract, however, is a perfectly safe supplement and found effective by many people in the treatment of migraine.

GINGER

If your migraine is at the front of the head, then you should try ginger. Unlike feverfew, ginger works on a migraine as it is occurring, and improvement can be achieved for a bad migraine within half an hour. In fact if, like many people, you can feel a migraine coming on, half a teaspoon of freshly ground ginger can stop the pain before it starts.

Many herbal treatments for migraine include a combination of some of the above remedies, and many people swear by them. However, migraine treatment is very personal, and you should use what works best for you. If you are also taking other medical treatments however, please make sure that you refer to your physician before using any others, and that includes herbal remedies or supplements.

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Migraine support available at Vitanet, LLC ®

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Date: November 21, 2007 10:31 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Support A Healthy Digestive System With Discount Vitamins

Discount vitamins can help to support a healthy digestive system, but to explain how they do you first need to know how the system of pipes, tubes and chemical plants that make up the digestive system basically works.

The digestive system is a system of tubes through which your food is passed during the various stages of digestion, and also organs that produce the chemicals needed to break down your food into the nutrients needed by the body. The digestive system begins with the mouth, where the teeth cut and grind the food, and mix it with saliva containing the enzyme amylase that begins the digestive process by converting starch into maltose and dextrin, which are later converted to glucose. Amylase cannot work in the acidity of the stomach, which is why you should chew starchy foods such as bread and potatoes before it is swallowed and passed down the esophagus to the stomach.

The stomach is a natural food processor, containing concentrated hydrochloric acid that breaks the food down into smaller molecules. Once the food has been mixed and processed it passes into the small intestine where the real digestion begins. The liver and pancreas manufacture digestive juices and pass them into the intestine as the food is expelled from the stomach. These juices are mixed with the food, break it downs chemically into nutrients which are then absorbed through the walls of the intestine. The waste is passed into the colon, from which they are later expelled.

While in the stomach, its glands produce not only the stomach acid but also enzymes that break up proteins into smaller compounds including amino acids. The liver produces a number of digestive juices, including bile that dissolves fats and renders them water soluble to be digested by enzymes from the pancreas. The liver also produces enzymes that further breaks down the food in smaller molecules.

The whole process is controlled by the digestive hormones that are generated by the stomach and small intestine, namely secretin, gastrin and CCK (cholecystokinin). These control the release of the various digestive juices and chemicals into the digestive system, and once the food has been broken down the nutrients are absorbed into the bloodstream and transported to the cells of the body where they are needed.

So, starting again from the top, how do discount vitamins and minerals help to support a healthy digestive system? First, we start with the teeth. It is essential for the proper use of food that it is shredded and ground properly before being passed to the body, and that the starches are broken down by the saliva enzyme amylase. The structure of your teeth is dependant on vitamin C and D, and the minerals calcium, phosphorus and magnesium. A deficiency in any of these would result in poor weak teeth, and your food would not be prepared properly for your stomach.

Vitamin B1 keeps your nerves in good working order, without which your appetite could not be regulated. Vitamin B3, or niacin, keeps the digestive tract in a healthy state and functioning properly. Vitamin B9, or folate (folic acid) carries out a similar task, and the B complex vitamins in general, then, keep the digestion process working smoothly and the peristaltic motion that moves the food along, also in good working order.

Manganese and chromium are essential minerals to the digestive system, without which enzyme activity would be limited and without chromium your appetite could not be controlled. Apart from that there is a lot that can go wrong with the digestive system and a good vitamin B complex or Vitamin B1 and B3 supplement, will help to maintain the proper functioning of the system. These vitamins will encourage proper control of the intestinal muscle function, and vitamins C and E will help deal with any inflammation in the bowel, or undue immune system activity. Acidophilus will also help to maintain a good population of healthy bacteria that are essential components of your digestive system. A probiotic supplement taken as instructed should achieve this.

A little considered function of the digestive system, perhaps because it actually takes place in the liver rather than the alimentary canal itself, is the disposal from the body of toxin absorbed by the small intestine. This is the chemical transformation of certain molecules into a form whereby they can be rendered water soluble and expelled in the urine. Substances such as drugs, alcohol, paint fumes and so on are formed into other chemicals that might be even more toxic than the originals for a short time, and since oxidation is used in many of these reactions, free radicals might be formed that can harm the body.

This danger, which is indirectly caused by the digestion of these substances, can be relieved by maintaining a sufficient intake of antioxidants in the form of Vitamins A, C and E to neutralize them. Some liver disease is caused in this way by insufficient vitamin nutrition, and a good discount vitamin supplement can help to prevent it by destroying the free radicals as they are formed.

This detoxification process then proceeds to a PHASE where the biochemically converted molecules are rendered into the water soluble form so that they can dissolve in the blood and be extracted by the kidneys into the urine. For this, a good supply of the tripeptide glutathione, glycuronic acid and some amino acids is needed. A supplement of these should also help the detoxification process.

Other supplements that can help the digestive system are natural enzymes. These work whether taken on an empty stomach or with food. On an empty stomach, at least two hours after a meal, they will immediately go to work in your blood and improve its condition. Taken with a meal they will help digestion the fats and reduce food waste by improving absorption.

There are many ways in which you can help to maintain a healthy digestive system by the use of discount vitamins, although any problem with your digestive system should be referred to your physician since there are many serious conditions that need expert medical treatment. Vitamins, enzymes, probiotics and other supplements, however, can help to prevent many of these from occurring.

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Discount Vitamins at Vitanet, LLC ®

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Date: November 15, 2007 07:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Wild Yam Natures Progesterone?

Dioscorea villosa, commonly known as wild yam, is a tuberous vine native to North America and parts of Central America. It was used by the Mayan and Aztec civilizations for pain relief and birth control and has also been given the names colic root and rheumatism root, demonstrating this early use of the plant. However, whether it is nature’s progesterone or not is another question that requires close analysis.

These Central American civilizations, of course, did not understand the reason why they were effective. Some of the symptoms treated can be caused by the menopause, and the wild yam is believed to contain natural forms of progesterone that can alleviate some of the adverse effects of the menopause on the body. Like most plants, they also likely act as anti-inflammatories, so relieving the pain of rheumatoid arthritis and other inflammatory conditions.

Like any natural remedy, wild yam had its adherents and its detractors, though in recent years the plant has been used as the raw material for the production of cortisone and a form of progesterone: or at least so it is claimed, so let’s have a closer look at these claims and determine whether or not wild yam is indeed nature’s progesterone.

The human body uses organic compounds called hormones to regulate many of the chemical activities of the body. The hormones catalyze the chemical reactions and changes needed for the proper functioning of our bodies. Hormones are produced in small chemical factories dotted throughout our body called glands. Each gland is devoted to producing a specific hormone, or a range of them, and each hormone is designed for a specific purpose.

Each has an associated hormone ‘receptor’ at their targeted destination that fits the hormone like a jigsaw piece. When it turns up, the hormone attaches to the receptor and the reaction proceeds. That might be the initiation of energy production in cells, the activation of certain genes or even the stimulation of hair growth by the follicles or of the libido and the natural desire to procreate.

Hormones are manufactured from only three constituents: proteins, amino acids and cholesterol, and the steroidal sex hormones are created from cholesterol. Therefore, don’t reduce your cholesterol level too much!

Prior to puberty, all of the sex hormones are manufactured by the adrenal glands, and after puberty by the ovaries in women and the testes in men. Progesterone is produced initially, and is then used as the building block for all the other sex hormones (hence the prefix ‘pro’). In women these are the estrogens and in males the androgens. Progesterone is made from the start of the menstrual cycle, and after day 12 they have reached a high enough level to halt ovulation. Progesterone levels continue to rise for about 8 days, and then if fertilization has not occurred, the progesterone levels trigger menstruation, and the lining of the womb is detached and expelled.

During certain PHASEs of the menstrual cycle, the levels of the hormones estrogen and progesterone drop off, although the exact reason for the many and varied symptoms of pre-menstrual syndrome (PMS) are still unknown to a large extend. There appear to be several contributing factors, though estrogen and progesterone certainly appear to be two of the major ones. We shall concentrate here on the progesterone factor because that is what wild yam is claimed to address.

Although the main function of progesterone is to generate estrogen and testosterone, to restore the libido after menstruation, and maintain the integrity of the lining of the uterus and aid in gestation, it has many other purposes such as in thermogenesis (burning of body fats), protection against osteoporosis and is also believed to have a natural anti-depressant action. These are all supported by the symptoms that appear when the body is low in progesterone levels: depression, sudden increase in body fat, mood swings, loss of sex drive and a susceptibility to weak bones if the deficiency is long-term.

In other words, women that usually suffer from PMS, also generally suffer low progesterone levels. It is believed in some quarters that a progesterone deficiency causes an excess of estrogen that leads to these symptoms in addition to heart disease. No one really knows for sure, but a deficiency of progesterone seems to be the determining factor.

Women with menstrual problems continue to be issued with prescribed synthetic progesterone even though they do not have the same effect as natural progesterone. They can also lead to some unpleasant side effects such as fluid retention, strokes, jaundice, blood clots and depression: some of the symptoms it is intended to alleviate. Some take borage or evening primrose oil for the GLA that helps some of the effects, but this is taken to counter the over-production of the hormone prolactin in some women prior to menstruation, not a deficiency of progesterone.

Wild yam does not cause these symptoms, and is claimed by many to be very effective in alleviating the symptoms of PMS. The problem with the artificial forms of progesterone is that the liver’s job is to destroy foreign hormones, and send them to the digestive tract for expulsion. Natural hormones are not affected in this way, even if they come from a non-human source.

The chemical diosgenin in wild yam is very similar in structure to progesterone, and is believed to be the active principle. It is claimed that it can be used to produce not only progesterone but also other related hormones. However, some medical authorities and practitioners dispute this claim, and there is still a question as to how wild yam works. Because it does work, many people swear by it and claim that they could not live without it.

This is especially true of those that suffer from the more severe effects of PMS, and since wild yam does not work for everybody, it could be connected with the severity of the condition and the symptoms. Whichever is true, there appears to be little doubt in the eyes of those that use it as a cream that wild yam is indeed nature’s progesterone.

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Natures Progesterone

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Date: July 29, 2007 11:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Supplements to Fight Prostate Cancer

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Buy Prostate Cleanses at Vitanet LLC

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Date: June 26, 2007 09:51 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Supplements for Children

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Date: May 11, 2007 10:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Breast Cancer and Natural Supplements

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Fight Cancer with Natural Herbal Supplements like calcium d-glucarate at Vitanet ®, LLC

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Date: April 10, 2007 11:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: D-Ribose Powder Benefits!

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Date: March 08, 2007 12:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Revita

Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.

Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.

To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.

Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.

Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.

Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.

In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."

In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:

• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.

• 78.9% of subjects showed an increased mean value of hair diameter.

• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."

Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth PHASE) and telogen (resting PHASE) of the hair follicle. When the anagen PHASE is prolonged, and the telogen PHASE is shortened, increased hair growth results.

Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:

• Total Number of Hairs: Significantly Increased

• Total Number of Terminal Hairs: Significantly Greater

• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher

• Hair Follicle Activation: Intensive

In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.

Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.

Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.

The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.

Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.

Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.

Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.

Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.

Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.

If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.

Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen PHASE increased by 6.4% and 8.4% respectively during the study.

The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.

After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.

Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.

MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.

The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.

MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.

Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.

The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.

According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.

The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.

Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.

Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.

The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.

Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.

Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.

Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.

L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.

The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.

Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.

In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.

Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.

Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.

Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.

Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.

After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.

This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.

Q. Is Revita safe ?

A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.

Q: Can I use hair sprays, mousses, gels, etc.?

A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.

Q: Can I have my hair colored or permed while using Revita ?

A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.

Q: What is SLS/SLES free ?

A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.

Q: Can I blow dry my hair after using Revita ?

A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.

Q: Who is a candidate for Revita ?

A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.

Q: What type of results should I expect with Revita ?

A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.

Q. Does Revita have any systemic side effects ?

A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.

Q. Does Revita work for women?

A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.

Q. I am using other topical treatments. Can I use Revita at the same time ?

A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.

Q. Do I need to use Revita for a long time ?

A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.

Q: Is stress a factor in hair loss?

A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1480)

Date: February 25, 2007 12:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Neurological Health and CoQ10

Between 1946 and 1965, 78 million Americans were born, creating the largest number of children in U.S. history. This Baby Boom generation has greatly influenced the makeup of American society and undoubtedly w ill continue to do so. Thanks to good nutrition and health care, Baby Boomers are aging well and have an excellent life expectancy. For the first time in history, we have more people turning 60 every day, and record numbers of adults reaching their seventh decade. As a result, neurological diseases associated with aging, such as Parkinson’s disease, are becoming major health care concerns. The good news is CoQ10 has applications for neurological diseases, in addition to its better known use for cardiovascular diseases.

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone (existing everywhere there is human life). CoQ10 is vital to the production of adenosine triphosphate (ATP). ATP is the energy-rich compound used for all energy-requiring processes in the body.

Q. Isn’t CoQ10 a supplement for heart health?

A. Yes, it is. Because the heart requires lots of ATP to meet its high energy needs, CoQ10’s function in heart health is well understood. Numerous clinical studies have demonstrated that when individuals with heart disease take CoQ10, their symptoms improve, sometimes quite dramatically. Supplemental CoQ10 improves the heart’s pumping ability, improves blood circulation, increases tolerance to exercise, and improves the heart’s muscle tone. CoQ10 also is a powerful antioxidant and protects heart tissue from free-radical damage.

Q. How does CoQ10 affect brain health?

A. CoQ10 works in the brain the same way it works elsewhere in the body: it’s essential to ATP production. Nearly all human cells contain tiny structures called mitochondria. Mitochondria are referred to as cell powerhouses because they produce cellular energy. Depending on what each cell’s job is. There can be several thousand mitochondria in one cell. If a cell needs a lot of energy, it will have more mitochondria. This explains why heart cells contain so many mitochondria; the continual pumping of blood requires continual ATP production.

The brain also requires huge amounts of uninterrupted energy to regulate, integrate, and coordinate ongoing nervous system transmissions. To meet this need, ATP production within the mitochondria of brain cells is vital. Since CoQ10 exerts such a powerful influence on heart cells in ATP production, it was a natural progression for scientists to wonder how it affects brain cells. Brain and nervous system research led to the conclusion that the same intracellular principles apply. CoQ10 is produced in the body to assist in ATP production. Without it, ATP cannot be produced.

The most important discovery regarding CoQ10 and the brain is that CoQ10, when formulated with certain ingredients, can cross the blood-brain barrier and enter the brain’s mitochondria. If large amounts of CoQ10 can get into the brain cell’s mitochondria, its ability to make ATP is greatly enhanced.

Q. What is the blood-brain barrier and why is it important?

A. The blood-brain barrier is a unique anatomical structure. The cells that make up the blood vessels that provide blood to the brain are extremely close together. This greatly restricts what can leave the bloodstream and enter the brain. While the blood-brain barrier protects the brain and spinal cord from potentially toxic substances, it also can be a significant obstacle to therapy of central nervous system disorders. Only substances with certain solubilities or those that have a transport system can cross the blood-brain barrier to a significant degree.

Obtaining optimal absorption of CoQ10 is difficult. The CoQ10 molecule is large and inflexible. The easiest and least expensive way to increase absorption levels is with the use of harsh solvents such as propylene glycol. However, at higher doses, these types of chemicals are considered dangerous (neurotoxic) to the person with a serious neurodegenerative disease. It is more difficult, as well as more expensive (considering raw materials, research, and proper manufacturing methods) to promote absorption with less harmful alternatives. However, reputable companies ensure that their products are safe for all their customers. Look for CoQ10 products formulated with vitamin E and other safe ingredients such as Micosolle.

Nearly all CoQ10 supplements enter the bloodstream. But, only CoQ10 supplements with special formulations have been scientifically shown to enter the mitochondria and cross the blood-brain barrier.

Q. If CoQ10 is made in the body, why take supplements?

A. While CoQ10 is synthesized in the body, these levels may be insufficient to meet the body’s requirements. Researchers have discovered CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. They also have determined some medications significantly reduce CoQ10 levels in the body.

Although CoQ10 exists in some dietary sources, it may not be realistic to obtain CoQ10 through food alone. For example, it would take approximately 3 pounds of sardines, 7 pounds of beef, or 8 pounds of peanuts to equal 100 mg of supplemental CoQ10.

Q. How does CoQ10 help people with Parkinson’s disease?

A. CoQ10 seems to have several beneficial actions in the illness. Researchers have looked at mitochondria in brain cells and determined people with Parkinson’s disease have reduced activity of Complex I in the electron transport chain. Recent research has proposed the reduced activity of Complex I interferes with the brain-signaling chemical dopamine. Stored and newly synthesized dopamine is depleted. The dopamine depletion causes nerve cell degeneration.

A recent clinical study involved 80 patients with Parkinson’s disease (both men and women). The researchers first evaluated all the participants to establish scores for basic motor skills (measuring the ability to control physical movements such as walking), mental status (whether the person was depressed or experiencing memory loss) and the activities of daily living (whether the person was experiencing difficulty with handwriting, dressing themselves, using utensils such as knives and forks, and so on). This scale is known as the Unified Parkinson’s Disease Rating Scale (UPDRS). This process is known as establishing “baseline values,” that is, the condition of the patient before receiving any treatment.

Participants were divided into 4 groups. Each group received either 300 mg, 600 mg, or 1200 mg of the special form of CoQ10, or a placebo. The researchers observed the participants for 16 months.

The results of the study showed that all the participants who received CoQ10 had smaller declines in function compared to the placebo group, but the smallest decline was experienced by the group taking the highest amount of the special form of CoQ10.

The most significant results were noted specifically in the activities of daily living scores by the people taking 1200 mg of CoQ10 daily. These people retained better ability to feed and dress themselves, speak, walk, and bathe or shower by themselves. They maintained greater independence for a longer time. Parkinson’s disease, as with other neurodegenerative diseases, robs the sufferer of their ability to control the movements of their own body and care for themselves. Supplementation with CoQ10, while not a cure, is the first intervention that showed a slowing in the progressive deterioration of the function associated with this disease.

Q. What were the results of clinical research on Huntington’s Disease?

A. A randomized, double-blind, placebo controlled study respected type of study, was conducted at the University of Rochester. All of the 347 Huntington’s disease (HD) patients were experiencing some HD symptoms, but were still in the early stages of the disease. The patients (who did not know which drug they were receiving) were randomly assigned to four different treatment groups: 25 percent received Remacemide, 25 percent received CoQ10, 25 percent received both, and 25 percent received a placebo, or sugar pill. The researchers, who also did not know which patients got which drug, watched and recorded their progress for two and one-half years. Remacemide is a new drug made by Astra Seneca that blocks the neurotransmitter glutamate in the brain, that has long been suspected of contributing to the death of brain cells in Huntington’s disease.

Unfortunately, in the CARE-HD study, Remacemide had no effect on the progression of the disease in patients in the early stages. However, the individuals who received 600 mg of CoQ10 per day experienced some slowing of the disease progression. They were able to manage daily activities, such as meal preparation, housekeeping tasks, and personal care longer than those not on CoQ10. They were also able to focus their attention better and were less depressed and irritable. The portion of the studied patients receiving 600 mg of CoQ10 per day experienced a 15 percent decline in the progression of HD. According to the researchers conducting the study, a 15 percent decline in the progression of HD would roughly translate into approximately one more year of independence for patients. This is the very first study from more than a dozen Huntington’s disease patient trails that showed any modification of the course of the illness.

Of note, the effects of the CoQ10 had not abated at the end of the research study. That is, the benefit of using CoQ10, 600 mg per day, was still increasing; this suggests that the longer a patient supplements with CoQ10, the greater the decline in the progression of HD. The next PHASE of the CARE-HD research will test a higher dose of CoQ10 (1200 mg or more per day), with more patients (over 1000), for a longer period of time (approximately 5 years). This study should improve our understanding of the optimal dose and the total achievable decline in the progression of HD. The CoQ10 product used in the CARE-HD study was designated an Orphan Drug by the FDA. The product utilizes a proprietary, patent-pending delivery mechanism, which is proven to be safe and tolerable at high doses for people suffering from neurodegenerative diseases, substantially improving brain tissue levels of CoQ10.

Q. What other diseases could benefit from CoQ10 supplementation?

A. Studies show CoQ10 levels are greatly reduced in Alzheimer’s patients. Mitochondrial abnormalities also are noted; however, research has yet to determine how or why this occurs. Some scientists believe damage to mitochondria is an early feature of the disease. Free-radical damage also is a feature of Alzheimer’s.

In a study of 27 Alzheimer’s patients, subjects were given 60 mg of CoQ10, 150 mg of iron, and 180 mg of vitamin B6 daily. Each patient’s mitochondria activity was effectively activated. All patients continued to experience gradual decline. However, researchers believed that with this combination, the progression was much slower and allowed the patients to experience 1 to 2 years of extended good health.

ALS (also known as Lou Gehrig’s disease) is a progressive, fatal, neurological disease. It occurs when the nerve cells in the brain that control voluntary movement gradually degenerate. Investigation of CoQ10 in individuals with ALS is just beginning. Researchers at the Eleanor and Lou Gehrig ALS Center at Columbia University recently conducted a small clinical pilot trial of CoQ10 in ALS. The study was an open label study, which meant that everyone enrolled received CoQ10, 400 mg three times per day. Of the 16 patients originally enrolled, nine patients completed the study. Six of these nine patients experienced some benefits. The patients declined from 0 – 25 percent in functional scores, 6 percent in strength, and 10 percent in breathing ability. These scores reflect a positive trend compared to the 50 percent decline that is seen in the natural history of ALS over the same period of time (5 to 9 months). Citing the need to conduct more studies of the effectiveness of CoQ10 for people with ALS is rapidly and efficiently as possible to get answers to patients and clinicians, another clinical trial is currently underway at the Gehrig ALS Center. This is a pilot study to determine if CoQ10 has short-term effects on motor nerves in the brain using magnetic resonance spectroscopy (MRS). The researchers are going to try to “see” if CoQ10 can change the chemical sin the brain’s upper motor nerves of people with ALS, an important next step of the investigation.

Q. Can taking CoQ10 prevent neurodegenerative disease?

A. To date, there have been no studies or research examining whether CoQ10 can prevent these diseases.

Alzheimer’s disease prevention is being clinically investigated. Researchers have determined that people who take certain anti-inflammatory medications seem less likely to develop the illness. A large, multi-centered trial is studying this connection.

Q. How much CoQ10 should I take?

A. Depending on your family history of neurological disease and your disease experience, studies show benefits at doses of 100 to 200 mg of CoQ10 daily. Some studies used doses of up to 1,200 mg per day.

CoQ10’s safety has been evaluated. To date, no toxicities have been reported. Mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.

Q. What should I look for in a CoQ10 supplement?

A. Use products which have a strong clinical research track record, supported by product-specific research from reputable institutions, and have been proven to be safe, tolerable and effective in treatment of neurodegenerative diseases. The CoQ10 product you choose should be proven to: be absorbed, enter the blood stream, cross the blood brain barrier and increase mitochondrial levels of CoQ10. If the product you are considering does not have evidence to support these points, keep looking. Once you have found a candidate, examine the product’s safety and efficacy record for neurodegenerative diseases- if the product has not been proven to be safe and effective, keep looking. Good products exist; however, caveat emptor.

Conclusion

CoQ10 supplementation for people with neurodegenerative diseases is supported by contemporary clinical research. CoQ10 is certainly not the only answer to the complex issues of management and treatment of these types of diseases. However, research indicates that it is a bigger piece of the puzzle than physicians and scientists ever imagined. As we continue to study this naturally occurring compound, we are finding more and more benefits to the body.

All CoQ10 is not created equal. For safety and overall effectiveness, use a CoQ10 product that is supported by product-specific research from reputable institution, which is proven to be safe, tolerable and effective at high doses; deviating from this set of criteria may do more harm than good for people with these serious illnesses. Choose clinically tested products from a well-respected company and increase the potential to achieve and maintain brain and neurological health.

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Buy Coenzyme Q10 (COQ10) at Vitanet

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1459)

Date: August 03, 2006 04:48 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: WasabiCleanse - Potent Liver Detoxification!

WasabiCleanse

Source naturals is excited to introduce WasabiCleanse, a powerful cleansing botanical that aids the liver in breaking down toxins. Wasabi familiar to most people as a fiery-sweet condiment that accompanies Japanese food has actually been used by herbalists in Japan since the 10th century.

Today, natural health researchers are rediscovering and confirming wasabi’s stunning health benefits, especially its potent phytochemicals that cleanse and detoxify the body.

Wasabi is a member of the cruciferae plant family, which also includes broccoli, horseradish, kale, and cauliflower. Wasabi contains precursors to phytochemicals called isothiocyanates, which induce the liver’s PHASE II enzymes. These compounds support the body’s ability to clean its self of impurities, particularly toxins stored in the liver’s fatty tissues. In today’s polluted environment, it is critical to your health and longevity that you cleanse these toxins from your body.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1340)

Date: August 01, 2006 10:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Wasabi Rhizome Cleanse - Supports PHASE II Liver Detoxification - Wasabi Health Benefits

Most people know of it as a pale-green lump on the side of their plates in Japanese restaurants—a hot, spicy accompaniment to sushi or sashimi. The fiery yet sweet taste perfectly compliments the saltiness of soy sauce and the cool delicacy of raw fish. But wasabi is much more than a burst of culinary flavor, it has been used by traditional herbalists of Japan since the 10th century and is now being rediscovered by modern health practitioners for its stunning health benefits.

Wasabi has powerful detoxification properties, in particular, it supports the immune system and cleanses the liver. Wasabi contains precursors to phytochemicals called isothiocyanates that help remove toxic substances that are stored in the liver’s fatty tissues.

The rare wasabi plant is a natural, potent support to a healthy, cleansed liver that in turn affects the detoxification and cleansing of the entire body. Source Naturals is pleased to bring you this convenient, effective addition to your wellness program.

Wasabia Japonica - Rooted In Health

The wasabi plant (Wasabia japonica) grows naturally in the mountains of Japan in the gravel and sandbars of coldwater streams and rivers. Rare and difficult to grow, it takes three years for a wasabi root or rhizome to reach maturity. Because of its popularity, wasabi is now cultivated hydroponically and in cold, wet environments outside of Japan, such as in New Zealand and Oregon. Traditionally, the rhizome was freshly grated at the table with a sharkskin grater, popular with dishes such as seafood or udon noodles. Now wasabi is usually dried into powder form and made into the pale green paste familiar to most westerners. Often, however, restaurants do not serve real wasabi; since it is so rare and expensive, a dyed horseradish paste is served in most American restaurants.

What makes wasabi so special? It comes from a good family; the brassica vegetables in the cruciferae family include such health giants as broccoli, horseradish, Brussels sprouts, cabbage, cauliflower and kale. All of these are well-known detoxifying plants, and wasabi appears to be the most amazing of them all, with detox capacities far beyond the others in the family because it is loaded with isothiocyanate precursors. This chemical not only gives wasabi its famous “fire,” it is likewise a fireball of detoxification properties.

PHASE II Detox

The liver detoxifies the by-products of digestion and other harmful substances through a complex series of chemical reactions often referred to as PHASE I and PHASE II Detoxification. PHASE I enzymes begin the process by taking the toxic molecule and changing it into a bioactive form. This process breaks down toxins. A second set of enzymes, PHASE II, then neutralizes the toxin and makes it water soluble for elimination. Wasabi, with its long-chain isothiocyanate precursors, induces the PHASE II enzymes. Simply stated, it is the sparkplug that starts PHASE II enzymes on their work. This process, all done in the liver, supports the body’s ability to clean itself of impurities.

Part of a Complete Wellness Program

In the modern world, with so many pollutants, it is critical to your health and longevity that you cleanse these toxic compounds from your body. Wasabi, along with a whole food, high-fiber diet and reduction of alcohol consumption, supports the liver— the largest of the vital organs and the key to the digestion and elimination systems and most particularly, the body’s ability to cleanse itself. Source Naturals is pleased to bring you this exceptional product as part of your wellness program.

Research

Depree, JA (1999) Flavour and pharmaceutical properties of the volatile sulphur compounds of Wasabia japonica. Food Research International: 31(5):329-337.

Morimitsu Y, et al. (2002) A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem: 277:3456-3463.

Munday, R (2002) Selective induction of PHASE II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables.

Nutrition and Cancer: 44(1):52-59.

Watanabe, M (2003) Identification of 6-methylsulfinylhexyl isothiocyanate as an apoptosis-inducing component in wasabi. Phytochemistry: 62(5):733-739.

Rose, P (2000) 7-methylsulfinylheptyl and 8- methylsulfinyloctyl isothiocyanates from watercress are potent inducers of PHASE II enzymes. Carcinogenesis: 21(11):1983-1988.

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Date: May 29, 2006 07:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: A Testosterone Breakthrough to Restore Health and Youth

There is a powerful new performance-enhancing ingredient clinically proven in humans. Its called LJ100 Tongkat Ali. Four years ago no one in the United States had heard of Tongkat Ali. Today the herb is becoming increasingly well-known as an athletic performance enhancer, overall youth-promoting agent, and libido builder.

Tongkat Ali is the popular folk name for Eurycoma Longifolia, a medium sized, slender rain forest tree. The name Tongkat Ali means Ali’s walking stick and the plant is native to Malaysia, lower burma, Thailand and Indonesia. Tongkat Ali enjoys a history of use that dates back to the 1700’s, and today there is a growing body of serious science that corroborates its traditional uses, specifically for the patented and proprietary brand LJ100 Tongkat Ali standardized extract containing 28% bioactive glycopeptides.

LJ100 Tongkat Ali

LJ100 is a proprietary, patented ingredient, and has become recognized as the premier brand of Eurycoma Longifolia for supplements that build and tone muscles, boost energy levels, decrease body fat, slow the aging process, and increase libido for health-conscious consumers. LJ100 has undergone an exclusive, patented extraction process to capture the most potent, biologically active compounds. SourceOne Global Partners, headquarters in Chicago, holds the exclusive distribution rights to market and sell LJ100 Tongkat Ali in dietary supplements.

ATP and Lean Muscle

In studies, LJ100 Tongkat Ali extract greatly increases ATP production. ATP, or adenosine triphosphate, is the basic unit of energy in the body, responsible for keeping us alive and going. By increasing ATP, overall energy and vitality are increased. Most people seek more energy and LJ100 Tongkat Ali provides it, without hyper stimulation, jittery nerves or insomnia. Promoting human energy production is a valuable health benefit by itself to make LJ100 Tongkat Ali an enduring botanical superstar. People want energy more than just about any other functional attribute.

Endocrinologists have known for a long time that testosterone increases the body’s ratio of lean muscle mass to fat. In both animals and humans, LJ100 Tongkat Ali increases muscle mass. In a study of men, half the subjects ingested LJ100 and half did not. In an eight-week physical training program the men who consumed LJ100 experienced greater gains in muscle mass and strength than those that did not. This demonstrates the powerful anabolic properties of Tongkat Ali. Instead of turning to the use of dangerous and potentially lethal steroids, it is recommended that more athletes opt for Tongkat Ali. In Malaysia, many professional field hockey players use LJ100 Tongkat Ali as an androgen and swear to its performance-enhancing effects. According to Chris Kilham, ethno botanist, author and lecturer, in a recent article in Physical Magazine,. “LJ100 Tongkat Ali has potential to revolutionize the sport nutrition category.”

Maintaining Normal cortisol / Testosterone Ratios

LJ100 is clinically proven to enhance weight loss and maintain high energy levels by maintaining normal levels of cortisol and testosterone during weight loss. More particularly, LJ100 studies have shown it to help maintain normal (low) cortisol and normal (high) testosterone levels during the stress of weight loss. This hormonal control provides energy to a person in a weight loss PHASE while simultaneously helping them lose weight. As a result, effective doses of LJ100 help prevent the body from seeking to gain weight by storing fat and increasing appetite. LJ100 can help stop the “yo-yo” diet effect where a dieter’s initial weight loss of a few pounds sends the body into catabolic state, leading to binge eating and fat storage.

LJ100’s Testosterone Breakthrough

LJ100 Tongkat Ali root contains numerous beneficial compounds, including potent protective antioxidants which inhibit cellular aging. What excites many people about LJ100 Tongkat Ali is that the root significantly boosts libido in men and women by increasing testosterone. Agents identified as glycoproteins are now proven to be the libido boosting ingredients in the plant.

Increasing testosterone is the key factor is the key factor in increasing libido. Testosterone is the most important of the male sex hormones, known as androgens, produced in the gonads. Testosterone plays a key role in the development and maturity of male sex organs. The hormone promotes secondary sex characteristics, including appearance of facial hair, enlargement of the larynx (producing a deeper voice), sexual desire and sexual behavior. Testosterone also stimulates metabolism, promotes lipolysis (Burning of fat), increases the formation of red blood cells and accelerates muscle growth.

Testosterone doesn’t stay with us from age 30 or so, blood levels of this hormone decline at a rate of about 2 percent per year. By age 50, the level is around 55 percent. As testosterone decreases, muscle tone, energy and sex drive all begin to decline. But testosterone is not just for men. The same decline in testosterone occurs in women, though the amounts involved are lower. In both sexes, sex drive, function, fat metabolism and energy decline into middle age.

One of the questions that many health researchers have pondered is what if you could boost your testosterone levels to more youthful levels? With LJ100 Tongkat Ali extract you can. And that makes LJ100 are true fountain of youth.

LJ100 Tongkat Ali “is the Greatest”

Don’t be fooled by wannabes. Only LJ100 delivers efficacy, standardization and supporting scientific research. When compared against lesser quality products, research showed LJ100 to increase serum testosterone levels 100% after two weeks, while some other products showed only an 8% improvement in serum testosterone level. Ali is the greatest only if it is LJ100 TongKat Ali.

Dr. Zheng-Xian Liu, PhD, has more than 18 years of experience in the Nutraceutical business and more than 34 years of experience in R & D. he received a doctorate of biochemistry and nutrition at Virginia Polytechnic Institute and State University. He was an NIH post-doctorate research fellow at Duke University Medical Center, specializing in free radical biochemistry, and a Pratt research fellow in nutrition. He also served as a member of the editorial board of journal of Advancement in Medicine and has published more than 60 papers in peer-reviewed scientific journals.

--
Buy TongKat Ali (LJ100) at Vitanet

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Date: February 12, 2006 03:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Best Alpha Lipoic 35!

Benefits Supports the Body’s Defense Against Free Radicals* Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E* Helps Maintain a Healthy Blood Sugar Level when used as part of the diet* Alpha-lipoic Acid––the "Ideal Antioxidant" The antioxidant potential of a substance is based on a number of criteria, including: 1) Ability to quench specific free-radicals. 2) Ability to bind or "chelate" metal ions that can generate free radicals. 3) Supports function of other antioxidants. 4) Absorption/bioavailability. 5) Concentration in tissues, cells and extra cellular fluids. 6) Ability to function as an antioxidant in fatty and watery environments. The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes. As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3 1) ALA is easily absorbed when consumed orally. 2) ALA is readily converted to DHLA in various tissues. 3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals. 4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions. 5) ALA and DHLA scavenge free radicals in fatty environments and watery environments. 6) DHLA recycles other important antioxidants. DHLA-regenerates vitamin C, vitamin E and glutathione Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants. DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7 Alpha-lipoic Acid and Blood Sugar Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10 Safety Suggested Adult Use: One to six capsules daily with food. Alpha-lipoic acid is considered safe, and no adverse effects have been seen with long-term supplementation.1 Scientific References 1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50. 2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63. 3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31. 4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21. 5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561. 6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous PHASE. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637. 7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87. 8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4. 9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14. 10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804. -- Buy Doctors Best Vitamins at Vitanet

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Date: December 27, 2005 09:08 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

HPLC is used to examine and verify potency claims on finished products and/or raw materials. For example, we use HPLC to measure the amount of active SAMe ion in our SAMe supplements, or the parthenolide content in organic feverfew herb. HPLC allows scientists to target and separate specific active ingredients from a solution by passing it through a sophisticated separation column combined with a mobile PHASE. The separated ingredients are then measured using ultraviolet light or other detection methods. Development of HPLC methods is a complex and precise science involving significant cost.

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Date: December 27, 2005 09:08 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

HPLC is used to examine and verify potency claims on finished products and/or raw materials. For example, we use HPLC to measure the amount of active SAMe ion in our SAMe supplements, or the parthenolide content in organic feverfew herb. HPLC allows scientists to target and separate specific active ingredients from a solution by passing it through a sophisticated separation column combined with a mobile PHASE. The separated ingredients are then measured using ultraviolet light or other detection methods. Development of HPLC methods is a complex and precise science involving significant cost.

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Date: December 07, 2005 01:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Immune Renew Fact Sheet

Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)

MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.

ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels

SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.

This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
2. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.
3. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. Epub 2002 Sep 10.
4. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162–8.
5. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790–6.
6. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1–6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].
7. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781–5.
8. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000–6.
9. Jones K. Shiitake: A major medicinal mushroom. Alt Compl Ther 1998;4:53–9 [review].
10. Taguchi I. Clinical efficacy of lentinan on patients with stomach cancer: End point results of a four-year follow-up survey. Cancer Detect Prevent Suppl 1987;1:333–49.
11. Matsuoka H, Seo Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some patients. Anticancer Res 1997;17:2751–6.
12. Guangwen Y, Jianbin Y, Dongqin L, et al. Immunomodulatory and therapeutic effects of lentinan in treating condyloma acuminata. CJIM 1999;5:190–2.
13. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256–66 [review].
14. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
15. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
16. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
17. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.
18. Gordon M, et al. A Placebo-controlled Trial of the Immune Modulator, Lentinan, In HIV-positive Patients: A PHASE I/II Trial. J Med. 1998;29(5-6):305-30.
19. Li JF, et al. Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-activated Killer Cell Activity in vitro. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1996;16(4):224-26.
20. Li KR, et al. Anti-atherosclerotic Properties of Higher Mushrooms (a Clinico-experimental Investigation. Vopr Pitan. Jan1989;1:16-19.
21. Shouji N, et al. Anticaries Effect of a Component From Shiitake (An Edible Mushroom). Caries Res. Feb2000;34(1):94-98.
22. Levy AM. Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms. J Allergy Clin Immunol. May1998;101(5):613-20.
23. Zjawiony JK. Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod. 2004 Feb;67(2):300-10.
24. Oliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 2004 Oct;4(8):873-9.
25. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
26. Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999 Sep;221(4):281-93.
27. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.
28. Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K. Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom). Int J Antimicrob Agents. 1999 Feb;11(2):151-7.
29. Rajewska J, Balasinska B. Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw (Online). 2004 Oct 5;58:352-7.
30. Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996 Nov;54(11 Pt 2):S91-3.
31. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. PMID: 15525457
32. Cheung NK, Modak S, Vickers A, Knuckles B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother. 2002 Nov;51(10):557-64. Epub 2002 Sep 20. PMID: 12384807
33. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004 Sep 30;113(1-3):77-83. PMID: 15380649
34. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
35. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
36. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
37. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
38. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
39. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
40. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
41. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.

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Date: October 26, 2005 12:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Research on SAMe....

Two groups of researchers have conducted analyses of trials that utilized SAM-e for mood enhancement. One meta-analysis was published in 1994. The researchers analyzed the efficacy of SAM-e in oral or injection forms based on published trials dated between 1973 and 1992. The authors concluded that there was a significant improvement of 17 to 38% seen in trials of SAM-e compared to placebo response. They state that the efficacy of SAM-e was superior to placebo and its administration caused few side effects.5 A second review was published in 2002. The authors analyzed studies in which SAM-e doses ranged from 200 to 1600 mg daily. They also found a significant effect of SAM-e in comparison to placebo, with an evident rapid onset of effect at enhancing mood.6

Promotes Joint Comfort and Mobility*

As a sulfur donor to connective tissue, SAM-e plays a major role in protecting the integrity of cartilage tissue. An in vitro trial assessed the actions of SAM-e in cultured human articular chondrocytes. At a concentration of 10 micrograms/ml, proteoglycan synthesis and sulfate residue incorporation in chondrocytes was shown to be 60% higher than control levels. Based on these results, it was shown that SAM-e has a positive influence on the growth and health of cartilaginous connective tissue.7

In a double-blind trial with 734 individuals with compromised joint health. SAM-e given orally at a dose of 1200 mg daily for 30 days was shown to significantly promote joint comfort compared to placebo, with a high level of tolerability and low incidence of side effects. The researchers concluded that SAM-e is a highly effective supplement for enhancing joint comfort.8

Another trial evaluated the response of individuals experiencing discomfort in the joints to a regimen of 1200 mg SAM-e for 1 week followed by 800 mg for the second week, and then 400 mg for weeks 3 through 8. This open trial of 20, 641 people showed a strong ability of SAM-e to enhance feelings of comfort within the joints. The treatment was rated as “very good” or “good” in 71% of the participants, with an additional 21% rating the treatment effect as “moderate”.9

In a long-term trial lasting 24 months, SAM-e was given to 108 participants with compromised joint function. Individuals were given 600 mg orally per day for the first two weeks followed by 400 mg daily for the remainder of the trial. Individuals experienced significant enhancements in joint comfort, with dramatic improvements noted after 2-4 weeks of treatment. Improvements continued to 6 months and beyond.10

In addition to the above studies, a review was conducted in 1987 to assess the results of SAM-e supplementation in clinical trials for enhancing joint mobility and function. Over 22,000 individuals had participated in the clinical trials that were the subject of this review. The author concluded from his analysis that SAM-e was shown to be highly efficacious, rivaling or surpassing the effectiveness of other treatments, and also possessing a high level of safety.11 Because of this, SAM-e may be the treatment of choice for enhancing joint function.

Supports Liver Health and Detoxification*

SAM-e supplementation can have profound benefits on liver function. These benefits center around its function as the major methyl donor in the liver, as well as its lipotropic activity. SAM-e also enhances the production of the antioxidant glutathione.

A number of trials have been conducted showing the ability of SAM-e to support liver detoxification functions and enhance liver health in individuals susceptible to toxin-induced liver compromise. SAM-e has the ability to normalize liver function by increasing the activity of enzymes needed to upregulate liver detoxification. These effects are comprehensive and rapid. Dosages used in these studies range from 600 mg to 1600 mg daily for 2 months to two years.12,13,14 In these trials, significant benefits of SAM-e supplementation were seen over placebo.

Safety

SAM-e has an excellent safety profile and is considered well-suited for long term use based on multiple clinical trials. Individuals diagnosed with manic depression should avoid SAM-e supplementation, as it may aggravate the manic PHASE *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Scientific References

1. Agnoli A, Andreoli V, Casacchia M, Cerbo R. Effect of s-adenosyl-l-methionine (SAMe) upon depressive symptoms. J Psychiatr Res. 1976;13(1):43-54.

2. De Leo D. S-adenosylmethionine as an antidepressant. Curr Ther Research. 1987;41(6):865-70.

3. Kagan BL, Sultzer DL, Rosenlicht N,Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 1990 May;147(5):591-5.

4.Salmaggi P,Bressa GM,Nicchia G,Coniglio M,La Greca P,Le Grazie C.Doubleblind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women. Psychother Psychosom. 1993;59(1):34-40.

5. Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: metaanalysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. 6.Mischoulon D, Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S.

7. Harmand MF, Vilamitjana J,Maloche E, Duphil R, Ducassou D. Effects of Sadenosylmethionine on human articular chondrocyte differentiation. An in vitro study. Am J Med. 1987 Nov 20;83(5A):48-54.

8. Caruso I, . Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med. 1987 Nov 20;83(5A):66-71.

9. Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis. Report of an open PHASE IV study with ademetionine (Gumbaral). Am J Med. 1987 Nov 20;83(5A):84-8.

10. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med. 1987 Nov 20;83(5A):89-94.

11. di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med. 1987 Nov 20;83(5A):60-5.

12. Frezza M, et al. S-adenosylmethionine counteracts oral contraceptive hepatotoxicity in women. Am J Med Sci. 1987; 293(4):234-238.

13. Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortolini M, Di Padova C. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology. 1990 Jul;99(1):211-5.

14. Mato JM, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999 Jun;30(6):1081-9.

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Research on SAMe - Vitanet ®

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Date: October 21, 2005 08:12 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: NOW is the leader in quality and value

NOW is the leader in quality and value

• Compare our price on trademarked ingredients such as ester-c, 7-keto, Carnipure, PHASE-2 and Relora to see how much money NOW can save you.

“We only deal with companies that support the natural products industry and have a strong public service mission”

We couldn’t agree more. NOW has, and will continue to fight for the rights of consumers to take safe supplements. As one of the most active and influential advocates in the natural products industry, we proudly support the following industry organizations.

NFA, Citizens for health, AHPA, OTA, The Herb Research Foundation, The American Botanical Council, Consumers for Health Choice (UK), The GMO Task Force, The GMP Task Force, American Herbal Pharmacopoeia, The Campaign to label Genetically Engineered Foods, AOAC (method validation), AOCS (American Oil Chemist Society), The Dietary Supplement Education Alliance (DSEA), and More…

“Does NOW support any Charitable or public services?”

NOW is a leading recycling company and was awarded a silver medal for nutrition business journal in 2005 for our dedication to environmental and sustainability issues. We use environmental-friendly packaging and procedures to ensure that our impact on the environment is minimal. Here are just a few of the charities and originations NOW generously supports:

Local Heal Clinics and food banks, Salvation Army, Marklund children’s home, African meal-a-day fund, compassion international, vitamin angel, world relief, Indian orphanage, Hephzibah children’s home, nature conservancy, Americas second harvest, world wild life, and many more

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Benefits of Alpha Lipoic Acid

Date: October 13, 2005 05:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Alpha Lipoic Acid

Benefits of Alpha Lipoic Acid

Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

Alpha-lipoic Acid––the "Ideal Antioxidant"

The antioxidant potential of a substance is based on a number of criteria, including:
1) Ability to quench specific free-radicals.
2) Ability to bind or "chelate" metal ions that can generate free radicals.
3) Supports function of other antioxidants.
4) Absorption/bioavailability.
5) Concentration in tissues, cells and extra cellular fluids.
6) Ability to function as an antioxidant in fatty and watery environments.

The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
1) ALA is easily absorbed when consumed orally.
2) ALA is readily converted to DHLA in various tissues.
3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
6) DHLA recycles other important antioxidants.

DHLA-regenerates vitamin C, vitamin E and glutathione

Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

Alpha-lipoic Acid and Blood Sugar

Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10

Scientific References

1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.

2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.

3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.

4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.

5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.

6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous PHASE. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.

7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.

8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.

9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.

10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.

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The Essential Woman Formula

Date: August 15, 2005 12:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Essential Woman Formula

The Essential Woman Formula

-Organic Unrefined Flaxseed Oil

The primary ingredient in The Essential Woman is unrefined organic flaxseed oil, the world’s richest source of essential fatty acids. These important nutrients, alpha linolenic acid (omega 3) and linoleic acid (omega 6) have been shown in scientific studies to benefit over 60 health conditions. Since these vital nutrients are classified as essential, they are absolutely necessary to maintain good health. Several of the most important benefits of essential fatty acid rich flaxseed oil include normalizing cholesterol and triglyceride levels, suppressing inflammation and allergies, alleviating depression, combating fatigue and beautification and healing of the skin. When it comes to these vital nutrients The Essential Woman is exactly that, essential!

-Evening Primrose Oil

Evening Primrose Oil is an integral part of The Essential Woman product for a very important reason. This proven and popular nutritional oil provides a source of specialized nutrient known as gamma linolenic acid or GLA. Volumes of scientific studies support the use of GLA for a woman’s unique requirements. GLA helps balance hormone like substances which, when out of balance, can lead to distressing symptoms of premenstrual syndrome. The Essential Woman was carefully formulated to provide optimal levels of GLA while working in concert with the other nutrient actives in the product.

-Lignans

Lignans are a class of plant phytonutrients that are concentrated in the solid portion of the flaxseed. These amazing compounds have shown such extraordinary potential that they have been studied by the National Cancer Institute for their cancer preventative properties. Lignans act as estrogen modulators, balancing human estrogen with both weak estrogenic and anti-estrogenic activity. This helps maintain a regulating activity on human estrogen which has been implicated as a factor in both breast and colon cancers. This is a particular concern for women as estrogen levels rise just prior to and during menopause. Lignans are yet another nutritional ally found in The Essential Woman necessary to meet the special demands of today’s woman.

-Soy Isoflavones

The simple soybean is a power house of nutritional factors. The much researched isoflavones in soy belong to a family of compounds known as bioflavonoids. The isoflavones in The Essential Woman are concentrated to provide optimal levels in every tablespoon. Scientific studies on isoflavones reveal an astounding array of nutritional benefits for women. Most notably are its effects on bone health and menopause. Researchers have found isoflavones effective in the prevention of bone loss and conclude that isoflavones are an effective natural means to help prevent osteoporosis and provide bone strengthening support. Soy isoflavones area also classified as plant phytoestrogens which are more delicate in their actions than the actual human estrogen, but target human cells in the same manner. In this way, isoflavones are believed to be able to block the overstimulation of human estrogens much like the plant lignans discussed earlier. This is good news for women entering their menopausal PHASE of life. Isoflavones of phytoestrogens can help alleviate the annoying symptoms of menopause and PMS as well as help reduce the risk of fragile bones, heart disease, breast and other cancers. As more and more women take charge of their personal health and well being, the need for a comprehensive nutritional support system is vital. The Essential Woman provides a formula for success designed for the special needs of a woman’s body.

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Vitanet ®

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New Man Food

Date: July 27, 2005 04:31 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New Man Food

New Man Food

Listen up, guys. Masculinity isn’t defined by what you eat. It’s all about how well you hold up through the years, which means taking care of yourselves. So ditch the doughnuts, double burgers and draft beer, and adopt a healthier diet. Here’s how!

Back in 1982, a best-selling, humorous manifesto of masculinity known as Real Men Don’t Eat Quiche epitomized the male backlash against feminism, by then a formidable force in the American cultural landscape. But the joke, it turns out almost 25 years later, is on the men- and not just because quiche doesn’t have that many fewer calories than a Quarter Pounder. We may have maintained out mach-ness all these years by eating “manly food,” but we’ve become unhealthy and ultimately weaker because of it.

In 2000, the National Health & Nutrition Examination Survey revealed that among men 20 years and older, a whopping 65.1 million (67.2%) were considered overweight and 26.6 million (27.5%) were considered obese. Only 30.6 million (31.8%) of men 20 to 74 were considered to have a healthy weight. The fallout from such a fatness factor is that more men are dying each year of heart disease and related illnesses and more money than ever is being spent on health care (to say nothing of how poor male health affects the women and children who depend on the men in their lives). Another cheeseburger, guys?

Those numbers, though shocking at first, shouldn’t be that surprising. As a gender, men are more vain, ego-driven and stubborn than women. How does this manifest itself when it comes to wellness? Until a man is hit with his first health crisis, no matter what the age, he thinks he’s indestructible.

That’s why it’s so difficult to convince men to get regular medical checkups (which they should do especially when they hit 50). It’s not that many American men aren’t trying to lose pounds. It’s just that they are a bit misguided in their efforts. Weight-conscious men really gravitated to the Atkins diet. Why? Because at the same time the plan says to cut carbohydrates and increase protein, it gives men carte blanche to eat mass quantities of high-fat “manly” foods like beef and pork. Trading pounds for clogged arteries doesn’t seem like a good deal.

So the time has come for all American men to turn their testosterone-driven energy into changing their nutritional lifestyle. We have to stop eating the same high-caloric and fat-laden foods we usually consume in large doses and start pursuing a diet based on variety, moderation and balance. It’s time to start eating “new” man food: the kind of foods that will make us feel (and look) like a new man.

Out With the Old

But before we can embrace the new, we must wean ourselves off the old, particularly the male habit of eating food in humongous portions. Easier said than done because all of us, men and women, have found it hard to resist the marketing power of super sizing. Who among us wants to feel like and idiot because we didn’t double the size of popcorn, soda or french fries for a mere 49 cents? But resist we must.

We also have to steer clear of the killer Fs-fried food and fat. New York-based nutritionist Annie Hauck-Lawson, PHD, RN, says that also requires willpower because fried foods can be addicting. “They taste so good and fat conveys a lot of flavor,” she admits. “So the best strategy is going cold turkey to get that taste off the palate.” Hauck-Lawson also suggests not beginning a meal with fried foods or fatty meats.

“The start of the meal is when you’re the most hungry so you’ll eat the most during the first course.” She says. “If you start most lunches and dinners with a broth-based soup or a big salad, you’ll load up on high-fiber, high nutrient foods rather than high-fat foods and you’ll be too full to eat the bad stuff. Besides, food can be broiled with herbs and spices instead of being fried and still be delicious.”

Nutritionists like Hauck-Lawson strongly advise men to eat more fiber-base foods, which means adding more fresh fruits and vegetables (about five servings a day), whole grains and beans to the diet. Fiber may not sound manly, but it aids digestion, reduces the risk of colon cancer by moving waste out of your system, supports healthy cholesterol levels and makes you feel full so you won’t gorge yourself on those super-sized portions.

Hydro Power

And when you’re eating all those nutritious and healthy new man foods, please don’t offset the benefits by washing it down with soft drinks. Did you know that a can of cola contains 39 grams of refined sugar, which is equivalent to seven teaspoons of the sweet stuff? Okay, we know what you’re going to say when we mention water as an alternative. B-O-R-I-N-G! But you can’t ignore a liquid that is crucial to your hydration, digestion and metabolism. If you must drink something interesting with your meal, try an organic red wine, which can have a positive effect on cholesterol and blood pressure. (When the liquid is the meal, a smoothie can fill the bill.)

During and after your transitional PHASE into the new man food lifestyle, nutritional supplements can ensure that you get enough vitamins and minerals from your diet. Besides taking a general multivitamin designed for men, you should incorporate heart- and prostate-healthy supplements such as omerga-3 fatty acids (especially if you aren’t eating more fish), magnesium, lycopene (found in abundance in tomatoes), zinc and vitamin D, which supports bone health and offers cancer protection. (You should see a licensed practitioner for guidance on which supplements are best for someone in your age group.)

What it boils down to, guys, is choices. We can choose to be set in our unhealthy eating ways or act like men and do the work it takes to make the adjustments. “men have been stereotyped as meat and potatoes freaks and that view is fairly accurate,” says Hauck-Lawson. “Trying to get men to eat healthier has been difficult.” But then she offers a carrot that men just might bite on. “Look at it this way: if a man eats more fish, fruit and vegetables for the nutrients he needs to stay healthy, he looks smart. And to women, smart is sexy.”

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Strontium Bone Maker 60 VC - Strengthen Bones

Date: July 27, 2005 12:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Strontium Bone Maker 60 VC - Strengthen Bones

Benefits

Helps maintain strong, healthy bones.*

In Vitro and Animal Studies

Strontium is a bone-seeking mineral incorporated by ionic substitution for calcium onto the crystal surface of bone.2 In the test-tube (in vitro), strontium inhibits the activity of osteoclasts, bone cells that break down bone, or “resorb” bone as part of the normal bone remodeling process.3 The effect of strontium, in the form of strontium ranelate (a salt of strontium and ranelic acid), was studied in monkeys over a six-month period. Strontium altered the remodeling of bone in the monkeys, resulting in decreased bone resorption with a concomitant maintenance of bone formation. A trend toward increased volume of osteoid, the organic matrix of bone, was observed, although this was not associated with defects in bone mineralization.4 In another animal study, monkeys fed strontium at high doses for six weeks showed a marked increase in bone strontium content. No harmful effects on bone mineral chemistry or structure occurred.5 At low doses, strontium has been shown to increase the number of bone forming sites in thighbones of adult rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.6 Strontium was shown to reverse bone loss induced by estrogen deficiency in rats.7

Clinical Trials

Human clinical trials have examined the effect of strontium on bone in postmenopausal women. In the dose-ranging (PHASE 2) PREVOS trial, women in early menopause were administered strontium ranelate or a placebo for two years. Strontium ranelate was given at daily doses of 125 mg, 500 mg or 1 gram. (Total weight of compound; strontium plus ranelic acid). Compared to women in the placebo group, who lost bone, women on strontium at the 1 gram dose showed statistically significant increases in bone mineral density (BMD) of the hip, thigh and lumbar spine. Biochemical markers of bone formation, such as serum alkaline phosphatase, increased. No effect on markers of bone resorption was observed, leading to the conclusion that strontium ranelate, at the 1 gram daily dose, increased bone formation without decreasing bone resorption proportionally. It was concluded that 1 gram per day is the minimum effective daily dose of strontium ranelate in these women.8

In another PHASE 2 trial (STRATOS trial), 353 postmenopausal women with osteoporosis, who had experienced at least one spinal fracture, took strontium ranelate for two years at daily doses of 500 mg, 1 gram or 2 grams. Women on the 2-gram dose showed a significantly greater increase in lumbar spine BMD than those on placebo. The number of subjects who had new spinal deformities was significantly reduced.9 As in the PREVOS trial, serum levels of alkaline phosphatase, a marker of bone formation, increased, while markers of bone resorption (breakdown) decreased. The overall conclusion is that the minimum effective daily dose of strontium ranelate (whole compound) is 1 gram in early postmenopausal non-osteoporotic women and 2 grams in postmenopausal women with osteoporosis.10

PHASE 3 efficacy studies on strontium ranelate have been conducted on 1649 subjects in 12 countries. These studies began with an open-run (non-controlled study period in which subjects took calcium and vitamin D supplements to normalize their blood levels of these nutrients.11 Following this, two parallel groups were administered 2 grams daily of strontium ranelate or placebo for 3-years. The subjects continued to take calcium and vitamin D during the study. In subjects on strontium ranelate, BMD increased in the lumbar vertebrae by 14.4 percent and in the thighbone by 8.3 percent. The number and risk of vertebral fractures decreased.12

Safety

Suggested Use: Take two capsules daily. Calcium intake must also be adequate. Do not take this product with calcium supplements.

Strontium ranelate was well-tolerated in the trials discussed above. The incidence of adverse events in subjects on strontium ranelate was statistically equivalent to the placebo groups, and no negative effects on hematology and other biochemical parameters have been observed.

In view of the fact that subjects on the strontium trials also took calcium, and in some cases vitamin D, to maintain normal blood levels of these nutrients, it is important to ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.13 In rats with chronic kidney failure, strontium has been shown to cause osteomalacia, a condition in which bone is softened due to lack of mineral content. For this reason, people on kidney dialysis should not use strontium supplements.14

Scientific References

1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 1952; 13:59 -66.

2. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone 2001;28(4):446-53.

3. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 2002; 450:11-17.

4. Buehler J, Chappuis P, Saffar JL, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis) Bone 2001;29(2):176-79.

5. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996 Sep;11(9):1302-11.

6. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18(3):253-9.

7. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 1993;8(5):607-15.

8. Reginster JY, Deroisy R, Dougados M, et al. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose ranging, placebo-controlled PREVOS trial. Osteoporosis Int 2002; 13:925-31.

9. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis––a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87(5):2060-66.

10. Reginster JY, Meunier PJ. Strontium ranelate PHASE 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporosis Int 2003; 14(Suppl 3):S56-S65.

11. Meunier PJ, Reginster JY. Design and methodology of the PHASE 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis. Osteoporosis Int 2003;14(Suppl 3):S66-76.

12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350(5):459-68. 13. Grynpas MD, Marie PJ. Effects of strontium on bone quality and quantity in rats. Bone 1990;11:313-19.

14. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes osteomalacia in chronic renal failure in rats. Kidney Int 1998;54:448-56.

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Cancer fighter found in broccoli

Date: July 27, 2005 10:05 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cancer fighter found in broccoli

Remember when your mother told you to eat your broccoli? Research shows that mother just might know best. In a recently published paper, Dr. Paul Talalay of Johns Hopkins University School of Medicine indicates that studies in his lab show broccoli is rich in sulforaphane, a chemical that works as a powerful anti-cancer compound in laboratory mice.

Other studies have shown that a diet rich in cruciferous vegetables—which include broccoli, Brussels sprouts, cabbage, cauliflower, and others— can significantly reduce the risk of cancer of the bowel, stomach and breast. Until now, the exact reasons why these vegetables had this effect we re not very clear. Until now, that is. According to Dr. Talalay, it appears that at least one anticancer ingredient in the vegetables is sulforaphane, which essentially causes cells to expel cancer-causing toxins. In addition, Dr. Talahay said that this study was the first to show that a high-potency compound isolated from vegetables could accelerate the detoxification process in cells.

The published report outlines how the research team isolated sulforaphane from broccoli, then fed it to a group of mice. When cells in the mice we re examined after five days, the scientists found that the chemical had triggered enzymes known to neutralize carcinogens within cells. Be yond this study, Dr. Talalay indicates that research will shift to the long-term effects of the chemical. “Our prediction is that sulforaphane will block tumor formation in animals and presumably in man.” In earlier studies, Dr. Talalay and others have shown that certain proteins in cells, called PHASE I enzymes, can take innocent chemicals and turn them into cancer-causing agents.

Other proteins, called PHASE 2 enzymes, tend to block formation of carcinogens. According to the study, sulforaphane is a potent activator of PHASE 2 enzymes. The Hopkins researchers will conduct tests to determine how much broccoli must be consumed to establish an effective anti-cancer level of sulforaphane in cells.

Over a decade of research has been done on cruciferous vegetables and there are large databases that confirm that cruciferous vegetables substantially reduce the risk of disease, specifically cancer. Studies show substances in these vegetables that have anti-cancer properties which cause the body to speed up production of enzymes, therefore being capable of neutralizing cancer agents. The studies also show these pre vent damage to our DNA and slow the aging process. In women, metabolic processes are regulated which eliminate the bad (and maintain the good) estrogen, therefore substantially reduce the risk of breast cancer. Shortly after the NCI study was released, John Hopkins School of Medicine revealed similar studies.

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SLEEP DISORDERS AND ST.JOHN'S WORT

Date: July 15, 2005 09:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SLEEP DISORDERS AND ST.JOHN'S WORT

SLEEP DISORDERS

Among the many ailments that often accompany middle and old age are various sleep disorders: insomnia, intermittent waking, sleep duration, and an overall poor sleep quality. The medical world has produced numerous synthetic drugs to deal with these disorders; however, most aren’t completely effective and produce undesirable side effects as well. Recent research suggests that St. John’s wort may be able to improve one’s sleep, especially that of older persons. A 1994 double-blind, placebo-controlled study published in the Journal of Geriatric Psychiatry and Neurology showed that Hypericum extracts gave the benefit of increased deep sleep during the total sleeping period of the patients. It explains, A hypostatic influence of the REM sleep PHASEs, which is typical for tricyclic antidepressants and MAO inhibitors, could not be shown for this phytopharmacon [Hypericum]. Instead, LI 160 [Hypericum] induced an increase of deep sleep during the total sleeping period. This could be shown consistently in the visual analysis of the sleeping PHASEs 3 and 4, as well as in the automatic analysis of slow-wave EEG activities. The study also makes an interesting connection between sleep and depression; that being many standard antidepressants and MAO inhibitors used to treat people who suffer from depression cause a decrease in deep sleep. As discussed earlier, St. John’s wort has shown great promise in treating depressed persons. So, besides helping people with sleep disorders, when used as an antidepressant, it gives antidepressant properties without the side effect of decreased deep sleep.21 This is certainly another valuable quality St. John’s wort has shown to possess.

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ST. JOHN’S WORT AND AIDS/HIV

Date: July 15, 2005 09:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ST. JOHN’S WORT AND AIDS/HIV

ST. JOHN’S WORT AND AIDS/HIV

In 1991, some of the first work focusing on St. John’s wort’s effects on AIDS and the HIV virus began. Science magazine reported on the first study using the isolated hypericin, a key compound in Hypericum.16 Fred Valentine and Howard Hochster, researchers at New York University Medical Center, began one of the first studies looking at how hypericin can help uninfected T-cells from being infected with the AIDS virus in a cell culture. Their focus was on hypericin because it is a virucidal agent, meaning it can precisely target new virus particles and prevent them from infecting other cells.

The only two drugs at that time approved for treating HIV infection—AZT and ddI—work by interfering with the key viral enzyme, reverse transcriptase. Since hypericin works more effectively than many drugs in regards to the reverse transcriptase PHASE, and since many animal tests have shown that it has low toxicity at therapeutic doses, researchers (including Valentine and Hochster) began these studies largely hoping that not only would hypericin work on its own, but that it would have a sort of synergistic effect when used with either AZT or ddI. 17

Additional studies are pointing to St. John’s wort, and more so, hypericin, as having great potential in treating HIV. Acosta and Fletcher recently detailed the processes in which the human immunodeficiency virus works to infect human cells, and point out that hypericin is at least somewhat effective in inhibiting the four main PHASEs of virus “growth”— binding and entry, reverse transcriptase, transcription and translation, and viral maturation and budding (the researchers note that hypericin is especially effective in binding and entry, the first PHASE.) This denotes that hypericin could eventually have special importance in completely stifling the development of the growth of any virus, and most importantly, that of the HIV virus.18

Another study assessing the use and attitudes of HIV sufferers concerning the use of more alternative treatments for the virus as opposed to clinical drug therapies showed both an extensive use of unconventional therapies and a very favorable response to using the alternative treatments, which, of course, St. John’s wort was among. “Participants at all sites expressed positive views upon increasing unconventional remedies.”19 The fact is that the world of synthetic medicines has been basically ineffective in not only treating and relieving the symptoms of AIDS, but also in finding a cure for the dreaded disease. Sufferers are giving alternative therapies a try, and the results are very promising.

A 1995 review appearing in Photochemisty-Photobiology treated the photodynamic properties of both hypericin and the structurally related hypocrellins for their anticancer and antiviral properties (especially the anti-human immunodeficiency virus). This article states that the promising anticancer and antiviral results obtained both in vitro and in vivo [in differing studies] have led to intensive investigation into their photo-physical and photochemical processes, especially kinetic studies of their intramolecular proton transfer . . . The biomedical advances of hypericins have been further promoted by significant progress in their chemical synthesis and the recent commercialization of . . . hypericin.20

Another study published in the September 1994 issue of Photochemistry-Photobiology gave hypericin the upper hand over the hypocrellins in treating HIV. Just one more vote in favor of promoting the use of St. John’s wort, and more specifically, hypericin, for use in treating HIV and in overall clinical medicine.

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Bio-Chelation

Date: June 29, 2005 05:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bio-Chelation

Bio-Chelation* By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt In The Beginning The Bio-Chelated¨ process describes a proprietary cold extraction technique developed by Mr. Frank D'Amelio Sr., founder and owner of Nature's Answer¨, and well- respected author*. Long before Nature's Answer¨ was formed (early 1970's), Mr. D'Amelio was immersed in the study of botanical medicine, researching the various herbal texts including the national USP/N.F. (United States Pharmacopeia/National Formularies) dating back to the mid -1800's. (The USP/N.F. is a reference source that provides manufacturing standards and extraction techniques used to make herbal formulas; these standards were considered official prior to 1938.) This authoritative formulary discussed the use of plant parts such as leaf, stem, bark, flowers and roots. It recommended certain solvents known as "menstruums", in which plant parts were soaked in order to extract their active constituents. High heat was also often utilized to concentrate the extract. Mr. D'Amelio noticed that high amounts of solvents, usually alcohol, were often recommended, and that sediment would fall to the bottom (precipitate) in certain solutions. He began to investigate how he could offer the consumer potent herbal products made with very low heat, with minimum precipitation, and without a lot of alcohol!

A Clue From Nature In working towards the goal of attaining a final botanical extract product with little alcohol, Mr. D'Amelio turned to Nature for the apparent answer. He realized that plants were composed of 80-85% water as well as some alcohols, fats, etc. If plants were able to keep the active constituents in solution and use them as needed mainly through water, not alcohol or other solvents, why couldn't he? Thus, he began a long, in-depth series of experiments with many different plants. Through rigorous research protocols and scientific testing, he discovered that the active constituents of some plants could be extracted using lower alcohol amounts with water and other natural solvents such as organic apple cider vinegar or vegetable glycerine. At other times, however, higher alcohol was necessary, such as when he was extracting volatile oils like menthol from peppermint. The experimentation process continued, with Mr. D'Amelio documenting the optimum menstruum combinations required for each plant to yield the maximum beneficial components. (Note that there are differences in alcohol. The alcohol consumed in wine and beer is derived through a natural fermentation process with no processing other than filtration. When distilled alcohol is added to an extraction, which some herbal manufacturers use, it effects the body in a more detrimental way; thus the development of the Bio-Chelation¨ process, which uses only organic alcohol).

The Bio-Chelated¨ Method Is Developed As Mr. D'Amelio continued his experimentation with various plants and menstruums, his extraction processes became more refined, and eventually led to the development of the Bio-Chelated¨ method. The Bio-Chelated¨ method incorporates soaking for a period of time, using different menstruum ratios for different plants to optimize their therapeutic values. Furthermore, this procedure offers additional significant advantages when compared with other types of extraction processes commonly employed by competitors in the herbal industry.

Bio-Chelation includes the use of "cold extraction", where the plant parts are extracted without being exposed to excessive amounts of heat. Cold extraction helps the herb maintain vital minerals and other trace elements in solution, thus enabling the herb to keep its Holistic Balanceª intact. (Holistic Balanceª means that extracts retain as many of the natural constituents of the original plant as possible.) In addition, the Bio-Chelated¨ process incorporates the use of an exclusive technique that removes much of the alcohol used during the menstruum soaking (maceration) PHASE, replacing it with vegetable glycerin instead. The resulting yield is an herbal extract that is either alcohol-free, or has a low alcohol content. (Both alcohol-free and low alcohol products from Nature's Answer feature vegetable glycerin only. Glycerin is used because it helps bind certain plant constituents, is natural to the body, is easily absorbed by the cells and has little insulin response. Only vegetable glycerin has been used since 1972. In addition, all alcohol used in Nature's Answer's low alcohol formulas is certified organic.)

The Bio-Chelated¨ method was the first extraction process to yield a 12-14% alcohol extract in the herbal industry!

Nature's Answer Stands The Test of Time Over the last quarter of a century (since 1972), the Bio-Chelated¨ cold extraction process has been painstakingly tested and proven to stand the test of time. Incorporating Mr. D'Amelio's proprietary cold extraction process in today's manufacturing procedures continues to yield a measurably superior product. One such example is Saw Palmetto from Nature's Answer¨, a product that is produced utilizing our Bio-Chelated¨ method versus the more expensive CO2 method. Our Bio-Chelated¨, cold extraction process yields a product that not only contains the same amounts of active constituents as the more expensive CO2 extracted product, but features a higher percentage of polyphenols, the compounds responsible for the herb's antioxidant properties. The end result is a Saw Palmetto extract that maintains its holistic balance! (Note that most prior successful studies done on Saw Palmetto utilized grain alcohol extracts which contained naturally occurring polyphenols; the CO2 extracted products do not contain polyphenols!) Although larger quantities of herbal products are now being produced as compared to the earlier experimental batches made by Frank D'Amelio, his founding corporate philosophy remains intact - combine the greatest care with the highest quality of raw material to create the ultimate herbal extract that works. After all, that's what it's all about, isn't it? Bio-Chelated¨..Another reason to count on Nature's Answer Without Question! Manufacturing Highlights:

State-of-The-Art Laboratory Manufacturing Equipment HPLC, UV, IR, GC/MS, LC/MS, TOC and Densitometer 316 Pharmaceutical Grade Stainless Steel or Glass Lined Extraction Vessels (instead of the inexpensive, more commonly used plastic or polyethylene extraction vessels; these vessels are porous and may contain microorganisms, residual plasticizers that are difficult to clean and could cross contaminate different batches of herbs) FDA Registered & Pharmaceutically Licensed cGMP and SOP Compliant Manufactured in the U.S.A. *Botanicals - A Phytocosmetic Desk Reference (1999), Botanical & Herbal Folklore (1974), The Botanical Practitioner (1978) Bio-Chelated¨ is a registered trademark of Bio-Botanica Inc.¨ Holistic Balanceª is a trademark of Bio-Botanica Inc.¨

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Vitanet ®

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Alcohol-Free Herbal Extracts

Date: June 29, 2005 05:20 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Alcohol-Free Herbal Extracts

Alcohol-Free Herbal Extracts By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt

Alcohol: The First Menstruum

Liquid extracts are a time tested, effective delivery system for medicinal herbs. When choosing liquid extracts, read the label. You will usually see that they contain quite a bit of alcohol. Alcohol is used as a menstruum, or solvent that frees all of the constituents from the fiber and cellulose of the plant, so that the specific medicinal constituents we want become more bio-available to the body. Alcohol has traditionally been used as the menstruum of choice because it is one of the most effective solvents (materials used to pull out the constituents of the herb) that is both reasonably priced and not too toxic on the body. Most of the herbal extracts on the market today have an alcohol content between 30 to 70%.

Bio-Chelation: A Revolutionary Concept

In the 1970’s Mr. Frank D’Amelio Sr., CEO and founder of Nature’s Answer®, noticed that the United States Pharmacopeia (the text that was used as a formulary for herbal processing), recommended using high amounts of alcohol to extract active constituents from the plant. He began to wonder how he could offer consumers potent herbal products without a lot of alcohol. One clue from Nature that became apparent to him was the fact that plants themselves were composed of 80-85% water. Since plants were able to keep their active constituents in solution and use them as needed through the use of water, not alcohol or other solvents, why couldn’t he? He began a long, in depth series of experiments with many different plants. Through rigorous research protocols and scientific testing, he discovered that the active constituents of some plants could be extracted using lower alcohol amounts along with water and other natural solvents, such as organic apple cider vinegar. (Conversely, higher alcohol was necessary at times when volatile oils were being extracted such as menthol from peppermint.) The experimentation continued, as Mr. D’Amelio recorded the optimum menstruum combinations required for each plant to yield the maximum medicinal components. He further refined the process, eventually developing the proprietary Bio-Chelation® cold extraction method.

The Bio-Chelation technique describes an exclusive process that removes much of the alcohol used during the menstruum, or soaking PHASE, and replaces it with vegetable glycerin, yielding extracts that are either alcohol-free, or have a low alcohol content. In addition, the alcohol used in any Nature’s Answer herbal extract product has the further distinction of being ‘organic’.

The Bio-Chelation method yielded the first 12-14% alcohol extract in the herbal industry!

The Alcohol-Free Advantage

There are many reasons why people may not want to use herbs with high alcohol content. Some people dislike the strong taste of alcohol. Alcohol can stress a weakened or under-functioning liver in sensitive individuals, such as those suffering from allergies, environmental sensitivities, systemic candida, and/or a host of other health concerns. Furthermore, people in recovery from alcoholism cannot use alcohol. Finally, alcohol is not appropriate for young children.

Nature’s Answer's alcohol-free extract formulas replace alcohol with natural vegetable glycerin because glycerin helps to bind certain plant constituents and is easily absorbed by the cells. Glycerin occurs naturally throughout the body. It also makes up a portion of the cellular membranes. This gives glycerin an affinity for the body, making it an excellent carrier for herbs. (Nature’s Answer only uses “vegetable glycerin” in their products.) Another advantage of using glycerin over alcohol is that glycerin serves to protect and preserve the potency of the herbal extract in the bottle over the life of the product longer than alcohol would. Since alcohol easily evaporates, it can lose its effectiveness as a preservative for the herbal constituents as the amount of the alcohol in the bottle decreases. Glycerin, due to its viscosity (thickness) aids in maintaining the freshness and potency of the herb for the life of the product. Finally, glycerin has the added advantage of acting as a sugar-free natural sweetener, thus making the taste of some bitter herbs more palatable.

Nature's Answer®, the pioneer of the alcohol-free extraction process, is proud to offer a comprehensive line of both single herb extracts and combination herbal formulas that do not contain alcohol.

These statements have not been evaluated by the FDA. They are not intended to diagnose, treat, cure or prevent any disease.

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Vitanet ®

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REFERENCES

Date: June 25, 2005 08:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: REFERENCES

REFERENCES

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Hyattsville, Maryland: National Center for Health Statistics; 1994. 4 Center for Science in the Public Interest and McDonald’s Nutrition and You—A guide to Healthy Eating at McDonald’s: McDonald’s Corp,1991. 5 Bray GA. Appetite Control in Adults. In: Fernstrom JD, Miller GD eds. Appetite and Body Weight Regulation. Boca Raton: CRC Press, 1994:1-92. 6 Michnovicz JJ. How to Reduce Your Risk of Breast Cancer. New York: Warner Book Inc. 1994:54. 7 Carcinogens and Anticarcinogens in the Human Diet. National Research Council Report, National Academy of Sciences, 15 Feb. 1996. 8 Van Tallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979:32: 2723-33. 9 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:273. 10 Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16A-hydroxyestrone to estradiol in human breast concer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1988:85;7831-5. 11 Colditz GA. 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Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.

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Modified Citrus Pectin (MCP)...

Date: June 21, 2005 05:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Modified Citrus Pectin (MCP)...

Modified Citrus Pectin

By Isaac Eliaz, M.D.

Modified citrus pectin (MCP) is an essential nutrient for cancer prevention and treatment. It directly attacks cancer, thereby reducing the disease, but also has properties that enhance overall health. A true super nutrient! Let me explain how it can do all this.

Characteristics of Cancer Cells

Cancer cells are different from normal cells in a number of ways. One difference is they way they "look." All cells have a variety of molecules on their surface, which allow them to communicate with each other and their environment:

* They are "hands" that let the cell stick in place or move around.

Cancer cells have odd amounts or unusual molecular markers on their surface, which allow white blood cells to recognize the cells as cancerous and kill them. One type of molecule cancer cells have in excess is galectin-3. Galectin-3 molecules function as "hands" and help cancer spread. First, they are important in reaching out and stimulating growth of new blood vessels; this allows the cancer to obtain the blood flow and nutrients it needs to grow out of control. Second, galectins allow cells that break off from the primary tumor to clump together in the blood stream, enabling them to move to new sites. Third, the galectin hand can grab hold of the new location and complete the metastasis, or spread, of the cancer.

MCP Blocks the Spread and Growth of Cancer Cells

Modified citrus pectin is a natural substance that can bind to galectin molecules and block their spread and growth. Early research on prostate cancer showed that oral administration of MCP to rodents resulted in a dramatic reduction in prostate cancer metastasis to the lungs. More recent research by the same scientists extended MCP protection to breast and colon cancer, and showed that MCP blocks primary tumor growth and formation of new blood vessels.

Successful Clinical Trial

A commercially available form of modified citrus pectin was developed in response to the positive animal studies and tested in men with prostate cancer. A pilot trial using MCP at 15 grams a day and a subsequent PHASE II trial both showed that MCP slows prostate cancer progression, as evidenced by a reduction in the rate of PSA rise. PSA (prostate-specific antigen) is a protein made by the prostate gland; elevated PSA blood levels may indicate prostate cancer. The PHASE II trial, published in Prostate Cancer and Prostatic Diseases (Dec 2003), involved men who at first experienced successful primary conventional treatment; subsequently their PSA again began to climb, representing cancer recurrence. Seventy percent of these men showed a significant reduction in the rise of their PSA climb! Because of the mechanism of action, it is expected people with other cancers (leukemia, breast, colon, lung, nasopharyngeal, brain, lymphoma, melanoma and others that express galectin molecules) also would benefit from MCP.

MCP Chelates and Removes Toxic Metals

Heavy metals, in conjunction with environmental toxins and xenoestrogens, constitute a dangerous insult to the body through DNA damage, hormonal modulation, immune suppression, oxidative stress, and hyper inflammation. The metal chelation properties of MCP (Eliaz, U.S. patent #6,462,029) have been confirmed in a recent pilot trial. In healthy individuals, MCP increased urinary excretion of the toxic metals mercury, cadmium, arsenic and lead. In addition, longterm administration of MCP has been shown to reduce the body burden of heavy metals such as mercury, arsenic, lead, and nickel. MCP's ability to remove heavy metals and environmental toxins on an ongoing basis may significantly benefit people with cancer and other diseases involving immune dysfunction.

Clinically Validated MCP

Only one form of MCP has been validated in human clinical trials. This is important since no other MCP on the market matches the chemical specifications of the clinically validated product. If the molecular weight of MCP is too high it can't be absorbed into the bloodstream. If it is too low it won't effectively block galectin sites. Another property, the degree of esterification, must be below 5% for optimal binding. The most effective specifications were defined by cell culture studies and remain a trade secret. If you want the effects seen in the clinical studies, you must take the preparation used in those studies, at the recommended dose of 15grams/day.

The Use of Modified Citrus Pectin

MCP Application Use (Take on an empty stomach) Active Cancer 15 grams/day (5 grams, three times a day) Biopsy 15 grams/day (5 grams, three times a day) Take one week before procedure and two weeks after. Heavy Metal Chelation High body burden levels: 15 grams/day (5 grams, three times a day) Lower levels: 15 grams/day for 5 days a month, 5 grams/day the rest of the month Cancer Prevention 5 grams/day ongoing

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Sytrinol - A Natural Solution for Addressing Cholesterol

Date: June 21, 2005 05:16 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Sytrinol - A Natural Solution for Addressing Cholesterol

Sytrinol - A Natural Solution For Addressing Cholesterol

By Richard F. Staack, Ph.D., M.B.A.

Sytrinol™, a patented proprietary formula derived from natural citrus and palm fruit extracts, combines citrus polymethoxylated flavones (PMFs), palm tocotrienols and other proprietary constituents. This combination results in a synergistic effect for maintaining cholesterol levels in the normal range, including total cholesterol, LDL cholesterol, and triglyceride levels, as demonstrated by a long-term, three-PHASE clinical trial. This trial is extremely significant because it is a randomized, placebo-controlled, crossover design, one of only a few in the dietary supplement industry. Sytrinol has also been shown to maintain normal levels of high-density lipoproteins (HDL), the beneficial cholesterol. Additionally, Sytrinol is a powerful antioxidant with numerous heart health benefits and also plays a significant role in reducing cellular irritation.

What are polymethoxylated flavones?

Polymethoxylated flavones are a highly methoxylated sub-classification of citrus flavonoids. This process occurs naturally and results in a more biologically active molecule. This is especially true for tangeretin and nobiletin, two of the primary polymethoxylated flavones in Sytrinol. Tocotrienols, naturally occurring analogues of tocopherol (natural vitamin E), are the other proprietary ingredient in Sytrinol and are a group of minor dietary constituents that have been studied for their effect on heart health.

Sytrinol's Proven Benefits

Sytrinol is the result of over 12 years of research focusing on the relationship between polymethoxylated flavonoids, tocotrienols, and cardiovascular health. Sytrinol?s benefits have been shown in vitro, in vivo, and in multiple clinical studies. In these studies, subjects consumed 150 mg of Sytrinol twice per day (300 mg/day) and were instructed to keep the same dietary habits and maintain their caloric intake. Fasting blood samples were drawn at study onset, and at 4-weeks, 8-weeks, and 12-weeks. The results of the clinical studies were all similar in their effect, with a reduction of total cholesterol up to 30 percent, LDL cholesterol up to 27 percent, and total triglycerides up to 34 percent in twelve weeks compared to the placebo group. Additionally, the LDL/HDL ratio was significantly reduced in all clinical studies up to 30 percent. Another very important benefit of Sytrinol that cannot be claimed by other cholesterol-addressing supplements is its effect on C-reactive protein (CRP), which plays a role in cardiovascular challenges. Recent research has established that inflammation may cause C-reactive protein to be produced in the body. Specific PMFs, including nobiletin and tangeretin, have been studied for their anti-inflammatory properties, suggesting that Sytrinol may have a positive effect on CRP Sytrinol has also been shown to be a powerful antioxidant. The polymethoxylated flavones have been researched for over 25 years demonstrating their antioxidant effects for heart health. Studies have shown that polymethoxylated flavonoids and their metabolites are excellent sources of dietary antioxidants that are able to suppress many of the events of free radical damage, including cellular irritation. The tocotrienols in Sytrinol have a higher antioxidant activity than tocopherols. Alpha-tocotrienol has been shown to be up to 60 times more potent than alpha-tocopherol in the prevention of lipid peroxidation. Other research has demonstrated that the delta and gamma isomers of tocotrienols also have potent antioxidant activity.

Mechanisms

Sytrinol has three complementary mechanisms of action in the body that delivers cardiovascular benefits. *Polymethoxylated flavones decrease apolipoprotein B, the structural protein needed for endogenous synthesis of LDL cholesterol. *Polymethoxylated flavones (tangeretin & nobiletin) decrease diacylglycerol acetyl transferase, a liver enzyme needed for endogenous synthesis of triglycerides. *Tocotrienols inhibit HMG CoA reductase, the liver enzyme responsible for endogenous synthesis of cholesterol. These mechanisms work synergistically to support normal total cholesterol, LDL cholesterol, and triglyceride levels, more significantly than other natural supplements on the market today. Sytrinol can also be combined with other ingredients such as phytosterols. Phytosterols help block cholesterol in the gastrointestinal tract while Sytrinol helps block cholesterol synthesis in the body. This suggests that, when combined, a more pronounced effect on maintaining normal cholesterol levels would result.

Consumer Friendly

The ease of compliance for consumers is a major consideration for a successful natural heart health product. Consumers do not have to take Sytrinol prior to, immediately following, or directly with their meals and, as a result, are more likely to take the correct dosage and continue using the product. Sytrinol can be taken in tablets, or softgels, which are easy to swallow because of the low dosage. Sytrinol will also be available in functional foods.

Dr. Richard Staack is the Vice President of Business Development, Technology, and Science at SourceOne™ Global Partners. He received his Master of Science and Doctorate in Nutritional and Biochemical Toxicology from the University of Illinois, Urbana-Champaign. He received his Master of Business Administration with Distinction from DeVry University. Dr. Staack has received several awards and honors in the field of nutrition, is associated with numerous professional affiliations, and has published several articles on nutrition and toxicology in peer-reviewed journals.

Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.

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The important role the liver plays in maintaining health

Date: June 21, 2005 04:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The important role the liver plays in maintaining health

Most practitioners who practice various forms of natural medicine know the important role the liver plays in maintaining health in general. The liver is involved in thousands of biochemical mechanisms making it second only to the brain in importance and complexity. Natural health practitioners are also acutely aware of the detrimental effects on the liver of modern living, with its chemicals, excessive fat intake, pesticides, hormones, and stress. This suggests that we as a culture are in need of liver support. History suggests, and modern research is supporting, that botanicals have an important role to play in supporting a healthy liver.

Mechanistic Overview

The liver has an almost miraculous ability to biochemically transform, break down, store, eliminate, and build up the plethora of chemicals to which it is exposed. Many botanicals have a very specific effect of modifying these biochemical processes. Some botanicals can enhance the liver?s PHASE I (cytochrome P450) and PHASE II (glutathione conjugation) detoxification processes, promote the flow and production of bile (one means of eliminating toxins), inhibit the attachment of viruses or chemical antagonists to hepatocytes, strongly enhance the liver?s powerful antioxidant systems, or promote the regeneration of liver tissue-the liver being the only organ in the body except the skin able to regenerate itself. Many botanicals have been used historically for promoting liver health. Today, modern research is confirming these benefits while shedding light on their mechanisms of action. Following is an overview of a number of these botanicals.

Milk Thistle Silybum marianum

The extract of the seeds of milk thistle is perhaps the most well researched of all the liver supportive botanicals. Part of its benefit has been in its ability to scavenge free radicals and to stimulate the regeneration of hepatocytes. In Germany, it is the botanical extract of choice for use in supporting a healthy liver. Typically, an extract yielding a minimum of 70% silymarin (a specific class of flavonoids) is used clinically at a dose of approximately 420 mg of the extract daily (Morazzoni and Bombardelli 1995).

Schizandra Schisandra chinensis

Schizandra, known as bei wu wei zi in China, is one of the most widely used tonics of Chinese herbalism. Its original use was to support the health of the heart, kidneys and lungs and as a longevity tonic. Modern research has focused attention on its role as an adaptogen and for supporting a healthy liver. Adaptogens are substances that positively affect overall health by reducing stress mechanisms which can contribute to a number of biochemical reactions that can be detrimental to health. While the mechanism of action of adaptogens has not been definitively determined, the existing literature suggests they work endocrinologically through the pituitary and adrenals and substantially reduce the negative effects that stress has on the system (Wagner et al. 1994). In China and Japan, the modern use of schizandra has focused on its benefit in those in need of liver support. In one review of its pharmacological activity, stabilization of liver enzymes was reported in more than 5,000 people. The benefits were experienced within 20 days of administration of schizandra with 75% of patients returning to normal values (Chang and But 1986). A limited number of controlled studies similarly reported on the beneficial effects of the equivalent of 1.5 grams of schizandra for reducing elevated liver enzymes (Liu 1991). There are three primary mechanisms of action of schizandra reported with regards to its ability to support a healthy liver: 1) its ability to reduce lipid peroxidation induced by a number of different antagonists (antioxidant activity); 2) induction of hepatomicrosomal cytochrome P-450; 3) stimulation of protein biosynthesis and liver glycogen (Liu 1991). Such mechanisms make schizandra ideal as a liver-supportive botanical that is underutilized in the West.

Bupleurum Bupleurum chinense, B. falcatum

Bupleurum, also known as chai hu in China, is perhaps the most important of liver-supportive botanicals in China and Japan, and, like schizandra, is far underutilized in the United States, except by traditional Chinese herbalists. Traditionally, it has been regarded as an herb that helps to normalize the function of the liver from a traditional Chinese perspective. Modern research has identified a group of compounds known as saikosaponins that strongly support liver health (in humans and rats). Mechanisms of action specifically regarding liver health identified for bupleurum include anti-inflammatory activity, as well as its ability to stimulate the production and release of bile, thus facilitating the detoxification process (Wagner et al. 1996).

Sho-Saiko-To Minor Bupleurum

In Chinese herbalism, herbs are seldom prescribed singularly. Rather they are combined according to very sophisticated principles of formulation based on the differential diagnosis of the patient. One of the most widely used and researched botanical formulas for the health of the liver used in China and Japan is Sho-Saiko-To, known in China as Xiao Chai Hu Tang (Minor Bupleurum). This classic formula consists of the following botanicals: ginger, scutellaria, jujube, ginseng, licorice, pinellia and bupleurum. It is widely used throughout Asia for supporting liver health and currently is the subject of PHASE II clinical trials at Sloan Kettering. The formula with its main ingredient, bupleurum, was first introduced in Japan by Chinese Buddhist priests between the 6th and 8th centuries. Modern research suggests that Sho-Saiko-To modulates the immune response, specifically in addition to other mechanisms, by increasing levels of interleukin and interferon (Huang et al. 2001).

Holistic Context

To the same extent that herbs are seldom used singularly in Chinese herbalism, they are similarly used within a broader context that incorporates dietary and other lifestyle changes to support the botanicals. In my clinic, I routinely recommend that patients eliminate alcohol, coffee, sugar, and refined foods from their diet and eat whole grain foods, fish, and several servings of green vegetables daily along with their herbal program. For these individuals this is a simple program to follow, and many are able to live a normal productive life with a greater level of liver health. Such a liver-supportive program must be maintained as a way of life to lessen the burden that modern society and exogenous factors put on our livers.

Conclusion

The herbal world offers a potential natural health care approach that focuses on protecting and restoring the health and functioning of the liver. Both traditional experience and modern investigation suggest that botanicals can play a role in world health, specifically in promoting liver health.

Caution

The use of botanicals should be used under the guidance of a qualified health care professional. The combined use of conventional and natural therapies may not be appropriate. Before attempting to combine such therapies, discuss your therapeutic options with your primary health care provider.

References

Chang HM, But PH. 1986. Pharmacology and applications of Chinese materia medica. World Science. Singapore. Huang et al. Semi-quantitative analysis of cytokine mRNA expression induced by the herbal medicine sho-saiko-to (TJ-9) using a gel doc system. J Clin Lab Anal 15: 199-209. Liu GT. 1991. Pharmacological actions and clinical uses of Fructus schizandrae in recent advances in Chinese herbal drugs-actions and uses. Scientific Press Beijing. Morazzoni P, Bombardelli E. 1995. Silybum marianum (Carduus marianus). Fitoterapia LXVI (1):3-42. Wagner H, Noerr N. Winterhoff K. 1994. Plant adaptogens. Phytomedicine 1: 63-76. Wagner H, Bauer R, Peigen X, Jianming C, Offermann F. 1996. Chinese Drug monographs and analysis: Radix Bupleuri (chaihu). Verlag fuer Ganzheitliche Medizin Koetzting/Bayer. Wald, Germany.

Michael Tierra, L. Ac., O.M.D., is a clinician and world-renowned author of the best-selling Way of Herbs and Planetary Herbology. As product formulator for Planetary Formulas, he draws on 30 years of clinical experience to create formulas renowned for their dependability and effectiveness.

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Cancer fighter is found in broccoli

Date: June 14, 2005 06:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cancer fighter is found in broccoli

Cancer fighter is found in broccoli

WASHINGTON (AP) - Remember when your mother told you to eat broccoli? Scientists say they've proved mother knows best.

Dr. Paul Talalay of Johns Hopkins University School of Medicine said in a paper published today that studies in his lab show broccoli is rich in sulforaphane, a chemical that works as a powerful anti-cancer compound in laboratory mice. Studies have shown that a diet rich in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower, can lower the risk of cancer of the bowel, stomach and breast. How those vegetables caused the effect wasn't clear.

Now, Dr. Talalay said, it appears that at least one anti-cancer ingredient in the vegetables is sulforaphane. It works by causing cells to expel cancer-causing toxins. He said this is the first time a high-potency compound has been isolated from vegetables and has been shown to accelerate the detoxification process in cells. Dr. Talalay said his team isolated sulforaphane from broccoli, then fed it to a group of mice. When cells in the mice were examined after five days, the scientists found that the chemical had triggered enzymes known to neutralize carcinogens within cells. Research, Dr. Talalay said, will shift to the long-term cancer-fighting effects of the chemical. "Our prediction is that sulforaphane will block tumor formation in animals and presumably in man," he said. Nutrition and medical scientists are trying to find ways to prevent cancer through a diet rich in foods that have anti-tumor properties.

In earlier studies, Dr.Talalay said, he and others have shown that certain proteins in cells, called PHASE I enzymes, can take innocent chemicals and turn them into carcinogens, or compounds that can give rise to cancer by disrupting the genetic pattern in cells. Other proteins, called PHASE 2 enzymes, he said, tend to block formation of carcinogens. Sulforaphane, he said, is a potent activator of PHASE 2 enzymes. "There is mounting evidence that if you are able to raise the PHASE 2 enzymes, this will divert the carcinogenic compounds from damaging the [genes]," Dr. Talalay said. "By tilting this balance toward PHASE 2 enzymes, we can achieve protection from cancer." The Hopkins researchers will conduct tests to determine how much broccoli must be consumed to establish an effective anti-cancer level of sulforaphane in cells. Over a decade of research has been done on cruciferous vegetables and there are large databases that confirm that cruciferous vegetables substantially reduce the risk of disease, specifically cancer. Studies show substances in these vegetables that have anti-cancer properties which cause the body to speed up production of enzymes, therefore being capable of neutralizing cancer agents. The studies also show these prevent damage to our DNA and slow the aging process. In women, metabolic processes are regulated which eliminate the bad (and maintain the good) estrogen, therefore substantially reduce the risk of breast cancer. Shortly after the NCI study was released, John Hopkins School of Medicine revealed similar studies.

Due to these study results, the National Cancer Institute, the American Cancer Society, the National Academy of Sciences, the U.S. Department of Agriculture, John Hopkins School of Medicine and the FDA have all reached out to inform the public of the anti-cancer compounds found in cruciferous vegetables, and are advocating the daily consumption of these vegetables. The average American has been eating only 4 and one half pounds of these vegetables per year!

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Marilu Henner: Energy Personified!

Date: June 14, 2005 11:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Marilu Henner: Energy Personified!

Marilu Henner: Energy Personified! by Stephen Hanks Energy Times, January 3, 2005

Marilu Henner is an actress, dancer and author, a health, fitness and cooking guru and a devoted mom. Now she's also an advocate for nutritional supplements. In this revealing interview, she offers her thoughts on the battle to support consumer rights and to create a better health care system in America.

"So, you want to know what my schedule is after I finish talking with you?" Marilu Henner says, in an almost breathless voice. "Today's Tuesday, right? Tomorrow morning I leave Los Angeles [where she lives] for New York City so I can do the Tony Danza Show first thing Thursday morning, Then, I take a 9 am flight back to LA because my son has a sleepover birthday party. I have a 7 am flight to New Jersey the next morning because I'm speaking about mental health at a conference at a big country club. The next morning, I catch a 7 am flight back to LA for my son's soccer games, one at noon and the other at 2. Whew!"

Trying to keep up with Marilu Henner would make anybody feel out of breath because the woman is energy personified. At 52, her schedule includes acting in movies, on television and in the occasional Broadway show, writing books (she's authored seven, including Total Health Makeover and Healthy Life Kitchen), teaching online diet and exercise classes through her website (marilu.com), taking Pilates classes three times a week and raising two sons, Nicholas (10) and Joseph (8).

But now, on top of all that, the former star of the TV show Taxi has become a health and nutrition activist, speaking out in favor of the use of dietary supplements whenever she can. This past September, Henner testified at a hearing of the House Subcommittee for Human Rights and Wellness to advocate increased funding for research and full implementation of the Dietary Supplement Health and Education Act (DSHEA). During her testimony, Marilu described why she believes consumers should have access to more information about supplements and why the products should be made more accessible through both government initiatives and private health plans. "I believe that dietary supplements should be part of a campaign to improve our nation's health," Henner testified.

Energy Times recently caught up with Marilu at her Los Angeles home for a freewheeling conversation. Here, this vibrant yet down-to-earth celebrity displays her passion for health, nutrition and consumer issues.

Energy Times: You've become one of the most high profile celebrities to advocate a consumer's use of dietary supplements. What was your motivation to get involved in such a public way?

Marilu Henner: As a teenager, I had been a yo-yo dieter. I could be around 135 pounds and balloon up to 174. I knew I needed a different way of looking at my life. I couldn't concentrate on those stupid diets where I could lose 20 pounds in a week and then gain it all back over a weekend. But after my mom died at 58 in 1978, I said to myself, "It's not really about my body anymore, it's really about my health." I just became obsessed with health. I read everything I could get my hands on. I starting taking human anatomy classes, going to medical libraries and seeing nutritionists and doctors. And I started experimenting on myself, turning myself into my own guinea pig. It took me about eight years to put together a program. I always say that my health birthday was 1979, but it wasn't until 1987 that I could say I was living a completely healthy lifestyle.

ET: Were you ever really heavy when you were performing in a show? MH: Sure. When I first performed the role of Marty in "Grease" more than 30 years ago I weighed about 175 pounds. But I hid it well. When you wear those 1950s clothes you can get away with it.

ET: When did you start incorporating supplements into your health program? MH: Before I became pregnant with my first son in 1993, I had never been a supplement taker. But I started taking prenatal vitamins and dietary supplements when I was breastfeeding and they made me feel really good. After the pregnancy, I just kept taking them because I was getting the essential nutrients that I couldn't get from food alone. I was getting great stuff from my food, but with all the travel I do-you know, the eating on planes and in restaurants-I couldn't always shop for organic food. I had a doctor who understood the value of dietary supplements and encouraged me to use them. I've taken them ever since and I recommend them to my family and friends, as well as to people through my books and classes.

ET: What supplements other than vitamins do you find helpful in your total nutrition program? MH: I take vitamin E, omega-3 fish oils, antioxidants, garlic, coral calcium and echinacea supplements.

ET: So let's get back to why you decided to testify before Congress in support of supplement use. MH: I know that as soon as you put a celebrity face on an issue, people tend to pay a little more attention. When I was in Washington, I was able to tell Congress the personal stories I've heard about people who turned their lives around-from debilitating illness to vibrant health-when they got the information they need to make good choices. By good choices, I mean rejecting the manufactured foods of our society, with their over-reliance on sugar, meat and dairy, and the chemicals, hormones and steroids that usually accompany these products. Instead, we should be moving towards an organic, vegan diet that produces a sense of physical health. I also believe that a healthy diet includes the use of appropriate dietary supplements.

ET: Do you think that government is moving fast enough to reduce the restrictions on safe supplements? MH: Things could always move faster. But I remember years ago writing letters on behalf of people who wanted supplements without needing a prescription. When I would tell people about the benefits of soy products or supplements, they'd think I was nuts. Now those ideas are mainstream. The floodgates are open and people want to know more. You can't even keep up with all the information. I think that the government knows they're not going to get away with making people have a prescription to take their vitamins.

ET: What is the citizen's responsibility in all this? MH: We're in a real transitional PHASE and people should take responsibility to educate themselves. You have to question your doctors and recognize when something is or isn't working. You have to find a health practitioner who really knows their stuff.

ET: As you said, there's so much information out there, how do you decipher it all? How can someone be an educated information consumer?

MH: I know it's very difficult because there are so many options. Believe me, I've been doing this a long time and I'm glad I did the research. I think you have to read everything. You have to find a nutritionist/herbalist/doctor who's the real deal and knows what they're talking about. You have to recognize the symptoms in your own body and try to figure it out. I think if you start out with a good multivitamin, a calcium supplement, fish oils and vitamin E, that can be your base and you can't go wrong.

ET: Isn't a diet built on buying organic foods much more expensive? MH: Sure, it's a little more expensive. But there's nothing more expensive than bad health. There's nothing more expensive than food being thrown away because it doesn't taste right. Organic fruit tastes so much better than the perfect-looking fruits and vegetables sprayed with pesticides.

ET: What's your advice to people who want to start a workout and weight-loss program? MH: I'm always saying to people, "Look, you walk your dog, your cat stretches, your hamster runs on a hamster wheel. You're an animal, too, so go move, go do something." I know a lot of people believe that when you want to lose weight you have to go on these 1,200-calorie-per-day diets.

Well, my weight is always between 120-124 pounds and I eat close to 2,000 calories a day, but everything I eat is of quality. And I burn a lot of calories because I wear comfortable shoes and I move around in my life. I'm always strong, I never get sick and I feel like an animal.

ET: How do you view the future of healthcare policy in this country and where do you think nutritional supplements fit in? MH: I strongly believe that the general public needs more access to dietary supplements to maintain essential good health. American research and development has come up with really great products, but the American Medical Association and the drug companies have stigmatized supplements. So what's the result? Most Americans don't have access to safe supplements because they are not covered by their health plans, nor recognized as effective by the federal government. This really needs to be changed.

I think we should take 90% of what we're spending on drugs that barely keep people alive and start spending it on prevention, nutrition and changing lifestyle habits. In this country we're all about curing the disease rather than curing the patient. We don't look at the patient holistically and try to find out how the disease developed. Your doctor should be in charge of keeping you well, not keeping you in that strange state of, what I call, "dis-ease." It's like the medical and pharmaceutical establishment wants to keep you just sick enough so you'll continue to be a paying customer. They've convinced people to think they've got to take a pill to cure themselves rather than use their own bodies.

ET: Do you think medical schools will start training doctors to treat patients holistically and focus more on preventative medicine?

MH: I think we're seeing a lot more nutrition and alternative medicine specialists these days. And the general public is becoming more aware of health and nutrition issues then they were years ago. There's this groundswell of people saying "Wait, I need more information. Wait, my doctor's no longer God. I can't just keep taking these pills and trying to figure out all these warning labels and side effects."

ET: Do you plan on becoming more politically active on these issues? MH: Absolutely, I want to work with any organization that wants to improve school lunch programs, improve the healthcare system and get people more involved in understanding nutrition and disease prevention.

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Vitanet ®

Solaray - Ultimate Nutrition - Actipet Pet supplements - Action Labs - Sunny Greens - Thompson nutritional - Natural Sport - Veg Life Vegan Line - Premier One - NaturalMax - Kal

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Mane Attraction - lustrous Hair...

Date: June 14, 2005 08:19 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mane Attraction - lustrous Hair...

Mane Attraction by Chrystle Fiedler Energy Times, February 12, 2004

Everyone wants thick, lustrous hair. Think of the allure attached to the locks of Samson and Lady Godiva and-fast-forward to the present-the full heads of Antonio Banderas and Julia Roberts.

" We're naturally attracted to hair as humans; it catches the light, it frames the face, we like the feel of it," says Catherine Jones, ND, LAc, a resident naturopathic physician at Bastyr Center for Natural Health in Seattle, Washington. "Fair or not, historically in many cultures, rich, thick hair has been a sign of fertility and strength."

Along with that allure, latching onto natural ways to have great-looking hair gives you the benefits of looks and health. Every hair starts with a shaft that grows from a root. "The root is contained deep within the hair follicle," says Dr. Jones. "Each one has a sebaceous or oil gland, which supplies the hair with necessary lubrication as it approaches the surface of the scalp." Each hair follicle has its own growth cycle, including a resting period, the telogen PHASE, when hair falls out. Because of these constant hair PHASEs, each of us loses, on average, about 100 hairs a day.

" The number of hairs the average person loses in a day tends to increase in the fall as the leaves fall from the tree and tends to decrease in the spring as the bulbs emerge from the soil," Dr. Jones says. "We really are connected to nature." Stress-due to rapid weight loss, infection, anemia, prolonged illness, hormonal changes, hypoactive thyroid disease, autoimmune conditions, eczema or psoriasis-can influence hair growth and loss.

The Nature of Hair

Hair consists of proteins, lipids (fats), carbohydrates and pigment (gray hair has reduced pigment; white, none at all). Each shaft's structure is divided into a medulla, a cortex and an outer cuticle. " The cuticle is coated with an outside lipid-like layer, which protects the hair," says Dr. Jones. "As the hair grows out of the follicle, the cortex and cuticle become keratinized and harden." Dry or damaged hair is more susceptible to breakage. "The condition of the cuticle affects how the light reflects off the hair, giving it highlights and luster," Dr. Jones says. "Luster is affected both by what occurs inside the body as the hair is developing and what happens to the hair after it has grown from the shaft."

Sun, heat, moisture, pollution and hair products, dyes and bleaches can all dull the hair. "Applying chemical solutions to the hair, color, permanent waves or curl relaxers, damage the protein molecules that wrap around the shaft, leaving hair brittle and dull," says Christina Pirello, author of Glow: A Prescription for Radiant Health and Beauty (HP Books).

Conditioners and oils can leave a residue or weigh hair down. Hair sprays and products that contain alcohol can dry and damage the hair, as can using blow dryers and curling irons.

Hair's Natural Nutrients

To combat hair-raising havoc, feed your hair natural nutrients for health. Silica and plants that contain silica/silicon both strengthen hair and promote growth. "Silica is a good mineral for hair health," says Walter Siegordner, founder of The Aurora Group, a personal care company. "It helps in the keratinization process of the cells that produce hair."

" Silica is a mineral that is involved in the synthesis of bone and connective tissue," adds Dr. Jones. "The hair follicle contains connective tissue so silica may promote the health and function of the follicle itself." Silica-containing herbs include nettles (Urtica dioica), horsetail (Equisetum arvense), oatstraw (Avena sativa) and alfalfa (Medicago sativa).

Sea plants like seaweed and kelp also provide vital nutrients. "Sea plants are essential ingredients in many natural shampoos and can be used to fortify damaged hair," says Pirello. "They're rich in vitamin A that prevents the build-up of dead skin cells, which can clog the hair follicles, inhibiting the growth and health of the hair, and also contain vitamin B, linked to the prevention of oily hair, baldness and dandruff. Calcium found in sea plants is essential to the structure of the hair shaft."

Eaten on s daily basis, sea plants are rich in nutrients that help maintain healthy, shiny hair, free of split ends, Pirello says. Try wakame in soups and salads, kombu or kelp in bean and vegetable dishes, nori in sushi, and hiziki and arame as side dishes. Since hair health is affected by digestive health, the fiber found in whole grains also helps. "Fiber prevents accumulation in the intestines that can result in the formation of toxins," says Pirello.

Miso, she adds, is especially good hair food. It "is rich in living enzymes that ease digestion, fortify the quality of the blood nourishing the body and hair, and provide us with essential oils, vitamins and minerals."

Key nutritional support includes adequate protein and amino acids, essential fatty acids such as cold-pressed flax seed oil and fish oil, copper, vitamin A, vitamin E, vitamin D, biotin, iron and vitamin B5 (pantothenic acid). Zinc and selenium can help combat the effects of hyperthyroidism, which can result in thinning, lackluster hair.

Vitamin C can boost adrenal health. "When the adrenals are overtaxed and become fatigued, hair follicles will go into a resting PHASE," says Dr. Jones. (If you have a medical condition, she adds, check with your health care practitioner first before taking supplements.)

Ancient Chinese Hair Secrets

In Traditional Chinese Medicine, hair is associated with the kidneys' qi, energy that originates in these organs, and with blood quality. " From the traditional Chinese perspective, excess amounts of fat, protein, dairy, sugar, alcohol and salt in the diet acidify the body, damage the Kidney qi and are not good for the hair," says Dr. Jones. A diet rich in vegetables and grains is a great way to support healthy hair. "Iron and mineral-rich foods are considered blood builders and hair tonics. Foods such as blackstrap molasses, seaweed, nettles, and the herb polygonum multiflorum (also known as He Shou Wu and Fo-Ti) have been used throughout the years. Fo-Ti has also been used to prevent graying of the hair and support the immune system."

Revive Hair Glow

" Hair is extremely strong but at the same time it's extremely delicate," says Barsoum Bouchar, a cosmetologist and owner of the Virtuoso Salon in Birmingham, Michigan. "Many products work against the hair texture, so the cuticle is always raised. This causes tangles and split ends. With blow dryers, chemicals, colors and styling elements, the hair is tremendously abused." If you don't have to chemically treat the hair, he says, don't.

When replenishing the hair it's important to remember that it's composed of 97% protein and 3% moisture, says Bouchar. Shampoo cleanses the hair and removes buildup. "A moisturizer brings moisture back into the hair and smoothes the cuticle down, which is what makes hair shiny and gives it bounce. The one key ingredient in both shampoo and moisturizers is aloe vera. It heals the hair." " Avoid products with harsh surfactants like sodium laurel sulfate and propylene glycol," warns Siegordner. "These decrease the circulation in the scalp, reducing the pathway for nutrition to the hair bulb." Conditioners that aren't natural can also cause build-up. "When you apply heat to the hair through blow drying or styling, you end up 'burning' the hair," says Bouchar.

To stimulate hair growth, add a few drops of essential oils of rosemary, lavender and thyme to jojoba and almond oils, and rub into the scalp. Leave it overnight and then rinse it off. " Essential oils have antimicrobial and antifungal properties, stimulate the circulation to the hair follicles and combat dryness. They also smell good," says Dr. Jones.

For hair that's not chemically treated, "a vinegar rinse cleanses the hair, removes build-up and boosts shine," says Bouchar. Use one part vinegar to ten parts water, apply after a shampoo, comb though and rinse it off. To naturally lighten the hair, use the same ratio in a lemon rinse for five minutes for, say, four days in a row, and then stop.

If you want to color your hair, choose natural elements, too. "The best natural dye is henna," says Bouchar. "It's organic, just like hair is." Blonde hair becomes warmer with a coppery tone, brunette hair takes on a mahogany hue, gray hair looks like highlights.

Go Natural

To find a good natural hair stylist, Bouchar suggests asking which products they use and why. If your hair is chemically treated, it's especially important to work with a stylist you trust for the best care.

Keep your eye on the big picture when it comes to hair health. "Be proactive and treat the body holistically," urges Dr. Jones. "Nourish the glands, the organs and the vessels that are responsible for getting the necessary nutrients to the hair follicle. Pay attention to the physical, emotional and mental aspects of health. Once hair is lost it may come back but it will likely be thinner than it was before. It's important to take care of what you have."

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Vitanet ®

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Date: June 13, 2005 07:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Celebrating Women: Age Is Just a Number

Celebrating Women: Age Is Just a Number by Carl Lowe Energy Times, March 10, 2004

As women age, their physical needs shift. The health challenges that face a woman in her thirties do not match those of a woman in her fifties.

At the same time, some basic health needs stay constant: At any age, every woman requires a wealth of vitamins, minerals and the other natural chemicals that fruits, vegetables and supplements supply. She also constantly needs families and friends to support her spiritual health.

As the internal workings of your body alter, your lifestyle must stay abreast of those adjustments. Peak health demands a finely tuned health program designed with your individual needs-and your stage of life-in mind.

Ages 30 to 45

When it comes to maintaining health, younger women might seem to have it easier than older women. If they exercise and stay in shape, they maintain more stamina than women 10 to 20 years their senior.

Unfortunately, many women in this age group mistakenly think they don't have to be as careful about their lifestyle habits and their eating habits as they will in later decades. But even if your health doesn't seem to suffer from poor eating choices or a sedentary lifestyle right away, your foundation for health in later life suffers if you don't care for yourself now.

By age 45 you should have established the good habits that will carry you successfully through the aging process. As an added bonus, good lifestyle habits pay immediate dividends. If you pay attention to your nutrients and get plenty of physical activity when younger, you'll feel more energetic and probably enjoy better emotional health.

Set Health Goals

According to Gayle Reichler, MS, RD, CDN, in her book Active Wellness (Avery/Penguin), good health at any age doesn't just come to you-you have to plan for it. In order to stick to good habits, she says, "living a healthy lifestyle needs to be satisfying." Reichler believes that you need to picture your health goals to achieve them: "Every successful endeavor first begins in the mind as an idea, a thought, a dream, a conviction." Good health at this age and in later years requires a concrete strategy and visualization of how your body can improve with a healthy lifestyle.

Your long-term health goals at this age should include an exercise program that will allow you to reach a physically fit old age with a lowered risk of disability. In addition, your short-term plans should encompass losing weight, staying optimistic, living life with more vim and vigor, increasing your capacity for exercise and lowering your stress.

As Reichler points out, "Your long-term goal and your ideal vision establish what you want to achieve....[You should do] something good...for yourself every day and every week that makes your life easier and more consistent with your goals."

Develop an Eating Plan

Today, the average American gains about two pounds annually. As a result, every year a greater portion of the US population is obese and overweight. By controlling your food intake earlier in life, you may be able to avoid this weight gain. In his book Prolonging Health (Hampton Roads), James Williams, OMD, recommends basic changes to your diet that can provide long-term support of your health:

• Eat foods high in lean protein. Reichler recommends meats like lean beef, poultry, beans and non-fat dairy. • Eat fish. It provides a wealth of healthy fats and protein. "Fish, because it contains the good omega-3 fats, does not need to be lean; the same is true for soy products that do not have added fat," adds Reichler.

Get Supplemental Help

If you're in your thirties or forties and you don't take at least a multivitamin, start taking one today! A large body of research shows that taking vitamin and mineral supplements over a long period of time significantly supports better health.

Calcium and vitamin D are two of the most important supplemental nutrients, helping to build stronger bones now that can withstand the bone-loss effects of aging.

Calcium can also help keep your weight down. One study of younger women found that for every extra 300 milligrams of calcium a day they consumed, they weighed about two pounds less (Experimental Biology 2003 meeting, San Diego).

In the same way, taking vitamin D supplements not only helps strengthen your bones, it can also lower your risk of multiple sclerosis (Neurology 1/13/04). In this study, which looked at the health records of more than 180,000 women for up to 20 years, taking D supplements dropped the chances of multiple sclerosis (although eating vitamin D-rich foods did not have the same benefit). And if you're thinking about having children at this age, a multivitamin is crucial for lowering your baby's risk of birth defects and other health problems. A study at the University of North Carolina at Chapel Hill found that women who take multivitamins during pregnancy lower their children's risk of nervous system cancer by up to 40% (Epidemiology 9/02).

" Our finding, combined with previous work on reducing several birth defects with vitamin supplementation and other childhood cancers, supports the recommendation that mothers' vitamin use before and during pregnancy may benefit their babies' health," says Andrew F. Olshan, MD, professor of epidemiology at the UNC School of Public Health. "We believe physicians and other health care providers should continue to educate women about these benefits and recommend appropriate dietary habits and daily dietary supplements."

In particular, Dr. Olshan feels that folic acid (one of the B vitamins), and vitamins C and A, are particularly important for lowering the risk of childhood cancers and birth defects.

Ages 45 to 55

When you reach this in-between age-the time when most women have moved past childbearing age but haven't usually fully moved into the post-menopausal stage-you enjoy a propitious opportunity to take stock of your health and plan for an even healthier future. One thing that may need adjustment is your sleep habits, as sleeplessness is a common problem for women in this age group. Even if you haven't been exercising or watching your diet until now, it's not too late to start. Making lifestyle changes at this age can still improve your chances for aging successfully.

For instance, it is at these ages that women should have their heart health checked. Research published in the journal Stroke (5/01) shows that having your cholesterol and blood pressure checked at this time more accurately shows your future chances of heart disease than having it checked at a later date after menopause, in your late fifties.

" The premenopausal risk factors may be a stronger predictor of carotid atherosclerosis [artery blockages] because they represent cumulative risk factor exposure during the premenopausal years, whereas the risk factors...during the early postmenopausal years have a shorter time for influence," says Karen A. Matthews, PhD, a professor at the University of Pittsburgh Medical Center. In other words, Dr. Matthews' research shows that if you have high blood pressure and high cholesterol before menopause, you are at serious risk for a stroke or heart attack soon after menopause: These are important reasons that you need to start improving your health habits immediately.

Increase in Heart Disease

Before menopause, a woman's hormones and other physiological characteristics usually hold down her chance of heart disease. After menopause, when hormones and other bodily changes occur, the risk of heart attacks and stroke in women rises significantly. (Heart disease is the leading killer of women.) At least part of this increased risk is linked to the postmenopausal decrease in estrogen production.

Dr. Matthews studied about 370 women in their late forties, measuring their weight, their BMI (body mass index, an indication of body fat compared to height), blood pressure, cholesterol and blood sugar. Ten years later, after the women had entered menopause, she and her fellow scientists used ultrasound to measure blockages in these women's neck arteries (a sign of heart disease).

The researchers found that indications of potential heart problems (such as high blood pressure, high cholesterol and being overweight) when women were in their forties did indeed forecast future difficulties.

" Women who had elevated cholesterol, higher blood pressures and increased body weight before menopause had increased blood vessel thickening and atherosclerotic plaque formation in the neck arteries after menopause. Such changes in the carotid arteries are associated with an increased heart attack and stroke risk," says Dr. Matthews.

Heart Health Factors

The four main lifestyle factors you should adjust at this age to support better heart function are diet, stress, exercise and weight. According to Dr. James Williams, "[M]ore than any other cause, dietary factors are the most critical factor in cardiovascular disease." He recommends eliminating "dietary saturated fatty acids as found in flame-broiled and fried meats." He also urges women to eat more fish and poultry, consume organic fruits and vegetables and cut back on refined sugar.

Stress becomes an ever more important heart disease factor at this age as estrogen begins to drop.

" Our study [in the lab] indicates that stress affects estrogen levels and can lead to the development of heart disease-even before menopause," says Jay Kaplan, PhD, of the Wake Forest University Baptist Medical Center (The Green Journal 3/02).

Dr. Kaplan's research shows that stress in women ages 45 to 55 may reduce estrogen earlier in life and make women more susceptible to the arterial blockages that lead to heart disease. "We know from [lab] studies that stress can lower estrogen levels to the point that health is affected," he says.

Stress can also hurt bone health: In a study of 66 women with normal-length menstrual periods, estrogen levels were low enough in half of the women to cause bone loss, making the women susceptible to osteoporosis.

Exercise and Weight

Although exercise used to be considered to be mainly a young woman's activity, the thrust of recent research suggests that physical activity actually becomes more important to health as you get older.

A 17-year study of about 10,000 Americans found that exercising and keeping your weight down is probably the most important thing you can do to lower your risk of heart disease as you enter your forties and fifties (Am J Prev Med 11/03).

Of the people who took part in this study, more than 1,500 people died of heart disease. Those who performed the most exercise were thinner and had a 50% chance less of dying of heart disease than overweight nonexercisers.

" The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, a researcher at the Albert Einstein College of Medicine in the Bronx, New York.

An added benefit of exercise: If you burn up calories exercising, you can eat more and not have to worry as much about being overweight.

Supplements and Diet

If you're a woman at midlife, a multivitamin and mineral is still good nutritional insurance. Eating plenty of fruits and vegetables are also important for getting enough phytochemicals, the health substances in plants that convey a wealth of health benefits.

As you enter this age group, your immune system gradually slows down. To help support immune function, eating produce rich in antioxidant nutrients, and supplementing with antioxidants like vitamins C and E as well as carotenoids, can be especially important. For example, a study of people with ulcers found that people with less vitamin C in their stomachs are more likely to be infected with Helicobacter pylori, the bacteria that can cause peptic ulcers and is linked to stomach cancer (J Amer Coll Nutr 8/1/03).

This research, which looked at the health of about 7,000 people, found that vitamin C probably helps the immune system fend off this bacterial infection.

" Current public health recommendations for Americans are to eat five or more servings of fresh fruits and vegetables a day to help prevent heart disease, cancer and other chronic diseases," says Joel A. Simon, MD, MPH, professor of medicine at the University of California at San Francisco.

Calcium and Bones

At midlife, calcium continues to be a vital mineral for supporting bone health.

According to Gameil T. Fouad, PhD, "It has been routinely shown that a woman's calcium status and level of physical activity (specifically, the degree to which she participates in weight-bearing exercise) are positively associated with bone mineral density. It is less well appreciated that this is a process which takes place over the course of a lifetime."

Dr. Fouad adds that calcium works in concert with other vitamins and minerals to keep bones healthy: "Research in the United Kingdom involving nearly 1,000 premenopausal women over age 40 illustrates those women with the highest bone density tended to have the highest intake of calcium. Surprisingly, this study also demonstrated that calcium does not act alone: those women with the best bone health also had the highest intakes of zinc, magnesium and potassium."

Dr. Fouad stresses that supplements should go together with a lifestyle that includes enough sleep and exercise to help the body stay in top shape.

" As a general guideline," he says, "a woman concerned with her mineral intake should take concrete steps to make sure she is getting adequate rest, is eating a well-balanced diet focused on fresh fruits, vegetables and lean protein as well as getting adequate exercise....A multi-mineral containing bio-available forms of zinc, magnesium, copper and selenium is probably a safe addition to anyone's routine. Taking these proactive steps dramatically reduces the chances that deficiencies will arise."

Ages 55 and Beyond

Entering the post-menopausal PHASE of life can present challenging opportunities for a new perspective on life and health. While some signs of aging are inevitable, experts who have looked at how the human body changes with age are now convinced that healthy lifestyle habits can improve how well you can think, move and enjoy life well past age 55.

As Dr. Williams notes, "In your fifties, the force of aging is undeniably present: Your body shape changes and organ function declines, both men and women have a tendency to gain weight....Heart disease becomes more common, energy and endurance are considerably reduced and your memory begins to slip."

But Dr. Williams also points out that you don't have to age as rapidly as other people do. He believes you should employ a "natural longevity program...[that starts] to reverse the course of aging as early as possible."

One key to staying vital as you age is your outlook on life, an aspect of life that's greatly enhanced by strong social ties.

Avoiding the Aging Slowdown The latest research shows that one of the most crucial ways to slow the effects of aging is to exercise and keep your weight down. It won't necessarily be easy, though. The change in hormonal balance at this age makes the body more prone to extra pounds (Society for Neuroscience Meeting, 11/12/03).

" In women, it has been demonstrated that major weight increases often occur during menopause, the time in a woman's life in which cyclic ovarian function ends and the ovarian hormones estrogen and progesterone decline," says Judy Cameron, PhD, a scientist in the divisions of reproductive sciences and neuroscience at the Oregon Health & Science University.

In Dr. Cameron's lab trials, she has found that the decrease in estrogen after menopause "resulted in a 67% jump in food intake and a 5% jump in weight in a matter of weeks."

In other words, the hormonal changes you undergo as enter your late fifties causes your appetite to grow as well as your waistline: Developments that increase your chances of heart disease, cancer, diabetes, stroke and joint problems.

Vigilance against this weight gain is necessary to save your health: Start walking and exercising. Research on exercise in people aged 58 to 78 found that getting off the couch for a walk or other physical activity not only helps control weight but also helps sharpen your thinking and helps you become more decisive (Proceedings of the National Academy of Sciences, 2/16-20/04, online edition). This recent study, done at the University of Illinois at Urbana-Champaign, found that performing aerobic exercise improved mental functioning by 11% (on a computer test).

" We continue to find a number of cognitive benefits in the aerobic group," says Arthur F. Kramer, PhD, a professor of psychology at the Beckman Institute for Advanced Science and Technology at Illinois. "The brain circuits that underlie our ability to think-in this case to attend selectively to information in the environment-can change in a way that is conducive to better performance on tasks as a result of fitness." In simple terms, that means that walking at least 45 minutes a day boosts brain power as well as protecting your heart.

An Herb for Menopause

The physical changes that accompan> y menopause can be uncomfortable. But traditional herbal help is available: Black cohosh (Cimicifuga racemosa), an herb used for eons by aging women, has been shown in recent studies to be both safe and effective (Menopause 6/15/03).

" This [research] should reassure health professionals that they can safely recommend black cohosh to their menopausal patients who cannot or choose not to take HRT [hormone replacement therapy]," says researcher Tieraona Low Dog, MD, Clinical Assistant Professor at the University of New Mexico Department of Family and Community Medicine.

While HRT has been used to help women cope with menopause, a flurry of studies in the past few years have shown that HRT increases the risk of heart disease and cancer. Instead, black cohosh, which alleviates such menopausal discomforts as hot flashes, has been shown to be much safer.

Keeping Track of Crucial Vitamins

While continuing to take multivitamins and minerals at this age is important, some experts believe that as we grow older, vitamin D supplementation, as well as taking antioxidant nutrients, is particularly vital. Arthritis is a common affliction of aging, and rheumatoid arthritis (RA) is one particularly destructive form of this joint problem. But taking vitamin D can significantly lower your risk of this condition.

When scientists analyzed the diets of 30,000 middle-aged women in Iowa over 11 years, they found that women who consumed vitamin D supplements were 34% less likely to suffer RA (Arth Rheu 1/03).

Other vitamins are equally important to an older woman's well-being. For example, vitamins C and natural E have been found to lower the risk of stroke in those over the age of 55 (Neurology 11/11/03). In this study, smokers who consumed the most vitamin C and natural vitamin E were 70% were much less likely to suffer strokes than smokers whose diets were missing out on these vitamins.

Rich sources of vitamin C in food include oranges and other citrus fruits, strawberries, red and green peppers, broccoli and brussels sprouts. Sources of vitamin E include vegetable oils such as sunflower seed, cottonseed, safflower, palm and wheat germ oils, margarine and nuts.

Saving Your Sight

After age 55, your eyes are particularly vulnerable. Eight million Americans of this age are at risk for age-related macular degeneration (AMD), a condition that destroys structures in the back of the eye necessary for vision (Arch Ophthal 11/03). But you can drop your risk of AMD by taking supplements of antioxidant vitamins and zinc, according to researchers at Johns Hopkins' Wilmer Eye Institute.

Their research shows that a dietary supplement of vitamins C, natural vitamin E and beta carotene, along with zinc, lowers the chances of progressing to advanced AMD in certain at-risk people by about 25%. Daily supplements also reduced the risk of vision loss by about 19%.

The carotenoids lutein and zeaxanthin also help protect aging eyes. When scientists compared healthy eyes with eyes suffering from AMD, they found that AMD eyes contained lower levels of these vital nutrients (Ophthalmology 2003; 109:1780). Furthermore, they found that levels of these chemicals generally decline as you grow older.

Healthy at All Ages

When it comes to designing a healthy lifestyle, general rules like these can be followed, but you should individualize your plan to fit your needs. No matter which type of exercises you pick out or what healthy foods you choose, look for a strategy and a plan you can stick to. If you think a selection of foods are good for you but you absolutely hate their taste, chances are you won't be able to stick to a diet that includes them.

The same goes for exercise: Pick out activities that you enjoy and that you can perform consistently. That increases your chance of sticking to an exercise program.

Staying healthy is enjoyable and it helps you get more out of life every day, no matter what stage of life you're in.

--
Vitanet ®

Solaray vitamins - Ultimate Nutrition - Actipet Pet supplements - Action Labs - Sunny Greens - Thompson nutritional - Natural Sport - Veg Life Vegan Line - Premier One - NaturalMax - Kal

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The Science of Healthy Hair

Date: June 10, 2005 03:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Science of Healthy Hair

The Science of Healthy Hair

by Susan Weiner Energy Times, January 5, 2002

From the strength-giving mane of Sampson to the magically long locks of Rapunzel, hair has had the power to captivate since biblical times. Today, its lure is just as compelling and hair remains an important form of self-expression and self-image. A healthy head of hair is more than an asset to your appearance. A hairstyle can reflect a mood, an attitude or a personal style, while unkempt hair may reveal the status of one's emotional or physical health. Even a "good" hair day vs. a "bad" hair day can significantly determine how your frame of mind takes shape. We can't always control the frizz factor or the humid weather that makes our curls fall flat, but many natural approaches are available to allow us to put our best looking follicle forward. Whether your hair is sleek and stylish, long and slinky, spiky punk rock-hip or wash-and-wear, botanical-based products and proper nutrition can bring out the very best in your locks.

Don't Fool Mother Nature

No matter how often you cut, dye, perm or blow-dry your hair, Mother Nature, with the help of your DNA, has blessed you with a quite specific quality and quantity of hair. Styling may work to change the appearance of your hair, but nothing can change your genetics. Every hair on your body, from the soft down on your arms to the coarser, longer hairs on your head, grows from a cell-lined indentation called a follicle. The hair follicle consists of three cylinders; the central cylinder determines whether your hair is straight, wavy or curly. Each hair shaft alternately grows or goes into a dormant PHASE. "At any one time, approximately fifteen percent of the one hundred thousand or so hairs on the head are resting, while the rest are growing or lengthening," say Arthur Balin, MD, PhD, and Loretta Pratt Balin, MD (The Life of the Skin: What It Hides, What It Reveals, and How It Communicates, Bantam). Hair constantly comes and goes, falling out consistently even when it is healthy. Consequently, a normal head can shed up to one hundred resting-PHASE hairs a day. When hair is subjected to harsh chemicals and treatment, even more may fall out. If you're concerned with hair loss, gently pull on a small section of hair; if fewer than five hairs come out, hair loss is within normal range.

What's Your Type?

Normal hair is an elusive commodity in these stressed-out days of over-washed, over-dried and chemically treated hair. If your tresses look frizzy, tangle easily or generally lack moisture, they're probably dry. Dry hair lacks the proper oil content to maintain an ample sheen and is usually dull-looking. To gain back a natural shine, cut back on shampooing and use a natural conditioner formulated for dry hair. Look for essential oils such as jojoba, evening primrose, blue chamomile, and white camellia, and B vitamins (such as panthenol) and aloe vera, suggests Aubrey Hampton, founder of Aubrey Organics. Drinking plenty of water, eating a diet that's not ultra-low in fats and using a humidifier may also help improve dull-looking dry hair, points out David E. Bank, MD (Beautiful Skin: Every Woman's Guide to Looking Her Best at Any Age, Adams Media). (Excessively dry hair may be a significant sign of metabolic disease. If you don't notice a marked improvement in your scalp after taking measures to improve dry hair, or your hair is abnormally dry, consult your health practitioner to see if stronger cures should be implemented.)

Too Much Oil

Hair that appears greasy within 24 hours after shampooing is oily. In that case, try gentle shampoos and herbal rinses with essential oils including quillaya bark, amino acids mixed with saponins, non-coloring henna and peppermint. For an oily scalp and dry ends, condition only the ends. Styling products should be oil-free. For thin or flyaway hair, products with natural thickening agents such as panthenol can help pump up the volume. Color treated and damaged hair can benefit from sulfur-containing amino acids; check your natural foods store for hair care products that contain horsetail, coltsfoot and cysteine. Tea tree oil products are effective when you are trying to control dandruff and a problem scalp.

The Must-To-Avoids

If the label lists sodium lauryl sulfate, steer clear, warns Hampton. And, says Dr. Bank, sodium C-14-16 olefin sulfonate, a harsh chemical found in cheap shampoos, is the worst of the worst when it comes to offensive hair care ingredients. "You also need to watch out for sodium chloride-table salt-in the ingredient list. It's a cheap ingredient to thicken shampoo and strips the hair of oils."

Feed Your Head

To optimize shine and fullness, improve your nutrition, says Bruce Miller, MD, author of The Nutrition Guarantee (Summit Publishing Group). "Good nutrition is as essential to healthy, attractive hair as it is to clear, glowing skin," notes Dr. Miller. "Your hair directly reflects your care and feeding of it." Your hair consists of about 97% protein, containing nineteen of the twenty-two amino acids that form protein, explains Dr. Miller. If you skimp on quality protein, your hair may reflect this amino acid imbalance by breaking, cracking and splitting. Hair follicles pass on the nutrients you consume, nourishing the new cells that form the growing hair shaft. As the hair gradually pushes upward, the shaft is continually lubricated by the busy sebaceous glands. For a smoother transition through the shaft and undamaged hair, lecithin provides a welcome dose of lubrication, as well as the important B vitamins choline and inositol, vital to healthy hair. In fact, the B vitamins are crucial to the growth of full bodied, healthy hair. The B complex strengthens, forms and smoothes the hair shafts, and helps maintain an even hair color, even warding off the beginning of gray hair. For thick and shiny hair, vitamin A works in conjunction with the B vitamins. Zinc can strengthen the hair shafts by thickening them. Thicker and stronger hair shafts increase your chances of holding on to your hair and suffering fewer lost hairs. When it comes to hair retention, genetics count. The more hair your parents retained, the greater your chance of keeping yours.

Think Diet

If you're interested in optimal hair health, think nutrition. Eating for the sake of your curls is a lot like eating for overall health: plenty of fresh fruits and vegetables, healthy grains and lean sources of protein, including tofu and other soy-based foodstuffs. To support healthy hair, some experts advocate foods high in biotin, including brown rice, brewer's yeast, bulgur, green peas, lentils, oats, soybeans, sunflower seeds and walnuts. The natural phytochemicals in green tea may aid hair, while ginkgo biloba improves circulation to the scalp. Don't forget your daily vitamins and be sure to take an iron and B12 supplement.

Chinese Treatment

Herbs from China show great promise for helping hair. He Shou Wu, made from Polygoni multiflori (the eastern wild rose), is reputed by devotees to restore color, slow hair loss, and help hair grow back. In Chinese medicine, this botanical has been used as an adaptogen to boost overall health and longevity. Within the context of Traditional Chinese Medicine (TCM), He Shou Wu is supposed to strengthen the liver and kidney meridians and support healthy blood. Many Asians use the herb to promote higher levels of qi, the TCM concept that encompasses your life's overall energy.

Show a Little Tenderness

Long-term exposure to sunlight and seawater can damage hair, as can combing or brushing wet hair. Treat your hair with kid gloves, use natural products that are gentle on hair, and avoid chemical treatments. If you're looking to lose weight, avoid crash diets; a sudden drop in nutrition can cause deficiencies and lead to hair damage and loss. Keeping a wonderful head of hair means staying ahead of the curve with proper nutrition, the right supplements and a continuous program of TLC. In that way, you can maintain the crowning head of hair you've always coveted.

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The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

Date: June 09, 2005 05:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

The Latest Breakthroughs in Garlic Research

on Cancer and Cardiovascular Disease

Presented at the 2005 World Garlic Symposium

Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.

“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”

Presentation highlights included:

• Anti-glycation properties of aged garlic extract: possible role in prevention of diabetic complications, presented by Nessar Ahmed, Manchester Metropolitan University in England Aged garlic extract inhibited the formation of advanced glycation end products, which have been previously shown to increase the risk of diabetic complications ranging from heart disease to retinopathy, kidney failure, impaired wound healing and many more.

“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”

Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .

Abstracts

PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892

Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of PHASE II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.

INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA

Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.

INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany

Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.

Bibliographies

David Heber, MD, PhD, FACP, FACN

Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center

Matthew Budoff, MD, FACC

Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.

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Phase 2 Carbohydrate Blocker from Source Naturals ...

Date: June 01, 2005 09:37 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: PHASE 2 Carbohydrate Blocker from Source Naturals ...

PHASE 2 Carbohydrate Blocker

Source Naturals PHASE 2® CARBOHYDRATE BLOCKER allows you to enjoy the foods you love without the calories! It’s a clinically proven, non-stimulant, all-natural nutritional ingredient that "neutralizes" all the digestive enzyme alpha amylase before it can convert starch into glucose and then fat. Essentially, it allows foods such as potatoes, breads, pasta, rice, corn and crackers (carbohydrates) to pass through the system with less caloric intake. Derived from the white kidney bean, it’s the first nutritional ingredient that has been clinically and scientifically proven to neutralize starch.

Weight Control Is Acute Health Concern

Excess weight is the number one cause of death in the United States–with more than 300,000 lives lost per year. Statistics confirm 110 million overweight Americans, of whom 39 million are more than 30 pounds overweight. The number of overweight individuals has grown by epidemic proportions in the Western world and the trend is a grave one. According to Journal of American Medical Association research, during the past ten years overweight Americans have increased by 65 percent. And a new risk group is comprised of “fast-food-loving” children, of whom one in three now tips the scales at "overweight."

Weight Loss Is An Uphill Battle

One thing we know for certain about weight management is that for many people it becomes a lifetime struggle. And when these individuals lose weight, they more often than not gain it back. In fact, once off their diet, people rebound and put on an additional 10 percent, ending up heavier than before. One major “offender” when it comes to weight issues is the impact of carbohydrate consumption. Why do we gain weight when we eat carbohydrates? Complex carbohydrates are digested by alpha amylase, which breaks them down, principally as glucose. This glucose is then stored as energy or fat. It was theorized that a product that could block this activity would reduce the amount of carbohydrates converted to glucose. People balk at dramatic changes in lifestyle, no matter how many times your doctor may say “the best way to lose weight is to push yourself away from the table." So the goal is to identify a convenient way to cut down on caloric consumption, principally carbohydrates.

Powerful Starch Control

CARBOHYDRATE BLOCKER supports the dieter's quest for a healthy and simple weight loss when used in conjunction with the Maximum Metabolism Weight Loss Plan™. Several clinical studies have shown it to be effective in weight management. Carbohydrates (common foods such as pasta, bread, baked goods, rice, grains and potatoes) are high in calories. And a typical Western diet gets half its daily caloric intake from starch.

CARBOHYDRATE BLOCKER is available in tablets or tasty, fruit-flavored, chewable wafers. Both contain PHASE 2 (Formerly PHASEolamin 2250™), a highly refined derivative of white kidney beans. CARBOHYDRATE BLOCKER works by inhibiting alpha amylase, an enzyme that breaks down starch into glucose so that it can be absorbed in the body, thus decreasing caloric intake.

With CARBOHYDRATE BLOCKER, undigested starch may pass through the body unabsorbed. Taken just before meals, CARBOHYDRATE BLOCKER may limit the conversion of carbohydrate calories to glucose. CARBOHYDRATE BLOCKER is manufactured through a proprietary process and studies prove that it’s safe and easy to use. The studies indicate that there is no effect on the digestion and absorption of other foodstuffs, namely protein.

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Calcium D-Glucarate and Tumors

Date: May 27, 2005 09:40 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Calcium D-Glucarate and Tumors

Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Walaszek Z; Hanausek-Walaszek M; Minton J P; Webb T E Carcinogenesis (1986 Sep), 7(9), 1463-6. Journal code: 8008055. ISSN:0143-3334. United States. Journal; Article; (JOURNAL ARTICLE) written in English. PubMed ID 3091283 AN 86298867 MEDLINE

Abstract

Using as a criterion the inhibition of serum beta-glucuronidase activity, dietary calcium D-glucarate is shown to serve as an efficient slow-release source in vivo of D-glucaro-1,4-lactone, the potent endogenous inhibitor of this enzyme. Using the 7,12-dimethylbenz[a]anthracene model of mammary tumor induction in rats it is shown for the first time that feeding the rats calcium D-glucarate-supplemented diet after treatment with the carcinogen, inhibits tumor development by over 70%. Supportive evidence is presented for the theory that calcium D-glucarate inhibits or delays the promotion PHASE of mammary carcinogenesis by lowering endogenous levels of estradiol(estrogen) and precursors of 17-ketosteroids. Therefore, dietary glucarate can be used to lower blood and tissue levels of beta-glucuronidase, and in turn of those carcinogens and promoting agents which are excreted, at least in part, as glucuronide conjugates.

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Date: May 13, 2005 08:38 AM
Author: Darrell Miller (dm@vitanetonline.com)

Sulforaphane Stimulates the Body's Cancer-Fighting Enzymes

by Richard Conant, L.Ac, C.N.

The health benefits of vegetables were known historically, long before researchers began seeing a connection between vegetable consumption and cancer prevention. Over the last twenty years, evidence concerning this connection has steadily accumulated. The latest and most promising findings reveal that specific vegetable constituents—"phytochemicals" to use current scientific parlance— enhance the body's defenses against cancer.

This article will focus on one phytochemical in particular, a sulfur-containing compound called "sulforaphane." Found in Cruciferous vegetables such as broccoli, sulforaphane may prove to be one of our most powerful cancer prevention allies. Recent studies have shown that sulforaphane stimulates, or "induces," "PHASE two enzymes." These enzymes are an integral part of the body's elaborate detoxification system that renders carcinogens inactive. This detoxification system turns carcinogens and other toxic substances into harmless molecules that are excreted from the body.

We need not fear carcinogens—the body is equipped to deal with them.

These findings, coupled with an appreciation of the body's ability to defend itself against carcinogens, have the potential to dramatically change the way we look at cancer and substances in the environment that "cause" cancer. We need to minimize unnecessary exposure to carcinogens, and the staggering quantity of hazardous chemicals in the environment remains an urgent health concern, for cancer and many other health problems. But, knowing the body is equipped with the means to defend itself against toxins, we do not need to fear carcinogens as perhaps we have in the past.

The natural world is full of carcinogens.

What's more, even if you eat 100 percent organic food and live in a environment free of toxic man-made chemicals, you are still being exposed to carcinogens every day of your life. Food is the primary route of this exposure. Plants, for their own defense, produce over 99% of all the pesticides in agricultural products.1 Almost all foods—in their natural state—contain tiny amounts of naturally-occurring, potentially carcinogenic chemicals.

The point is not to trivialize the concern over environmental toxins. The point is that the natural world is full of toxins that are not man-made. These substances have been around since before we appeared, which is why we have evolved with a highly efficient system for neutralizing them before they can damage our cells and initiate the complex process that produces cancer.

Broccoli sprouts are a concentrated source of cancer-fighting sulforaphane.

We cannot avoid carcinogens. What we can do is support our internal detoxification system. Sulforaphane is a powerful tool in this effort. We can start by following the often-repeated advice to eat a variety of vegetables every day, and include broccoli in our menu.

There is an even richer source of sulforaphane than broccoli itself. In September 1997, a group of scientists at the Johns Hopkins University School of Medicine made a breakthrough discovery— broccoli sprouts contain ten to one hundred times more sulforaphane than mature broccoli.2 Vegetable sprouts are generally regarded as exceptionally healthy foods. Broccoli sprouts now look like a shining star, especially when it comes to cancer prevention.

For those lacking the time or inclination to keep a fresh supply of broccoli sprouts on hand, broccoli spouts have been processed into an extract that is even more concentrated in sulforaphane. More on this later.

What have researchers learned about broccoli consumption and cancer rates?

More than 200 epidemiological studies—studies which track groups of people over time to uncover realtionships between variables such as diet and the incidence of disease—have invesitgated the connections between vegetable consumption and various forms of cancer.1 It should be understood that findings from epidemiological research are generally not regarded as conclusive; these studies are not controlled, and often use data gleaned from questionnaires, which are an imprecise method of gathering information. (In the case of diet questionnaires, for example, the study subjects may or may not record their food intakes with 100 percent accuracy.)

Epidemiological studies look for trends. To be credible, these trends need to show up consistently, in different population groups. Findings from the vegetable intake/cancer studies easily meet these criteria; the number of studies is large and the trend is consistent—vegetable consumption is strongly associated with a lower risk of developing cancer.

What about broccoli in particular? A paper published in the September 1996 issue of Cancer Epidemiology, Biomarkers & Prevention analyzes epidemiological data gathered from 94 studies concerning the cancer preventive effect of brassica vegetables.3 (The Brassica genus, part of the Cruciferae family, includes broccoli, cabbage, kale, cauliflower and brussels sprouts.) The data suggest that broccoli consumption reduces the risk of some of the most feared forms of cancer, including stomach and lung cancer.

Now, to put these data into a balanced perspective, the researchers point out that in most of the studies reviewed, brassica vegetable consumption was reported as part of the total vegetable intake. "In hardly any epidemiological studies was the effect of brassica vegetables separated from the effect of total vegetables or other vegetables by adjusting for consumption of these variables. Therefore, it is difficult to sort out whether the observed observation was attributable to brassica vegetables, to vegetables as a whole, or to other vegetables," they noted.

This uncertainty is a good example of why epidemiological studies alone do not give us open and shut conclusions. But the paper also adds that the apparent anti-cancer effect of brassica vegetables agrees with "the results of experimental studies in which brassica vegetables reduced mammary tumor incidence, hepatic tumor size, numbers of tumors per liver, tumor frequency, and the number of pulmonary metastases when given to rodents before or after a carcinogen insult."3

When you put together a plausible trend from epidemiological research with results of experimental studies that agree with the trend, and then add additional research that reveals the underlying mechanism for these observations, a clear picture begins to take shape. And, indeed, we now have a fairly good idea as to just how brassica vegetables, especially broccoli, help prevent cancer.

How sulforaphane helps prevent cancer from developing.

To see how sulforaphane works, let's look at a brief overview of the body's detoxification system.

The detoxification of carcinogens and other toxic substances takes place in the liver, and involves two distinct enzyme-driven processes or "PHASEs". PHASE one enzymes neutralize toxins by various routes. Some of these convert toxins into substances that are immediately eliminated. However, other PHASE one steps convert toxins into intermediate products which are carcinogenic themselves, and require further treatment before they can be excreted. PHASE two enzymes do this vital job. PHASE two enzymes deactivate these carcinogenic metabolites of PHASE one, and the final breakdown product is then eliminated once and for all. (For an excellent review of this subject, see Encyclopedia of Natural Medicine, by Drs. Michael Murray and Joseph Pizzorno.4)

PHASE two is critical. If PHASE one is in good working order, but PHASE two is not, the potential threat from carcinogens increases. It is vitally important to keep PHASE two operating well. This is where sulforaphane plays its cancer preventive role. Sulforaphane is a powerful inducer of PHASE two enzymes.5,6

Broccoli sprouts-the ideal source of sulforaphane

Sulforaphane is one among a group of phytochemicals called "isothiocyanates." (These occur in brassica vegetables largely as "glucosinolates," which are precursors for isothiocyanates2,12 When the plant is crushed, glucosinolates are converted to isothiocyanates.) Sulforaphane induces PHASE two enzymes exclusively, leaving PHASE one enzymes alone. This means it helps reduce the load of carcinogenic PHASE one intermediates without adding to the load by stimulating PHASE one.8,9

As reported by the Johns Hopkins University research group, broccoli sprouts are an "exceptionally" rich source of sulforaphane (in the form of "glucoraphanin, sulforaphane's glucosinolate precursor). And broccoli sprouts have another advantage over mature broccoli. They contain almost no indole glucosinolates, phytochemicals present in mature broccoli that "can enhance tumorogenesis."2

Broccoli sprouts as an extract, now available as a dietary supplement, takes the concentration of sulforaphane to the next level. This recently developed nutraceutical product contains a potent 20 to 1 extract of three-day old fresh broccoli sprouts.

One 125 mg capsule supplies the same amount of sulforaphane as 125 grams, or about 5 ounces, of mature broccoli. Taking just one capsule a day is like eating two pounds of broccoli per week, which equals the intake of cruciferous vegetables believed necessary to obtain their health benefits.

References

1. Steinmetz, K.A. Potter, J.D. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc. 1996;96:1027-1039.

2. Fahey, J.W., Zhang, Y., Talalay, P. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. 1997; 94:10367-10372.

3. Verhoeven, D.T.H., et. al. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiology, Biomarkers & Prevention 1996;5:733-48.

4. Murray, M. Pizzorno, J. Encyclopedia of Natural Medicine. Rocklin, CA: Prima Publishing;1998:110-120.

5. Zhang, Y. Talalay, P, Cho, C., Posner, G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. 1992;89:2399-2403.

6. Gerhäuser, C. et. al. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces PHASE 2 drug-metabolizing enzymes. Cancer Research 1997;57:272-78.

7. McDanell, R., McLean, A.E.M., Hanley, A.B., Heaney, R.K., Fenwick, G.R. Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Fd. Chem. Toxic. 1988;26(1):59-70.

8. Talalay, P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. in Advances in Enzyme Regulation, Vol. 28, Weber, G., Ed., 1989: Pergamon Press.

9. Prochaska, H.J. Santamaria, A.B., Talalay, P. Rapid detection of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. 1992;89:2394-98.

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Date: May 12, 2005 10:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Under-Reported (and Underappreciated) Cholesterol control.

Under-Reported (and Underappreciated) Solutions for Cholesterol and Triglyceride Control

Fat and human existence are inseparable. Setting aside the fear and loathing over fat in the body that pervades our culture, we understand that fat is our friend. We cannot live without fat.

The human body contains many different kinds of fats and fat-like molecules. Collectively known as "lipids" these fatty substances include fatty acids, lipoproteins, phospholipids, glycolipids, triglycerides, steroid hormones and the infamous, dreaded cholesterol.

Lipids (fats) are found everywhere in the body, performing a variety of vital functions. The brain is a fat-rich organ. Brain neurons and all other nerve cells are protected by a myelin sheath, made largely out of fatty material. Cell membranes consist almost entirely of phospholipids (lipids that contain phosphorus) arranged in a sandwich-like double layer embedded with proteins. Sex hormones are lipids, belonging to the group of complex lipid molecules known as "steroids." Vitamin D is a lipid.

The body stores and transports fatty acids in the form of triglycerides. A triglyceride contains three fatty acid molecules, which have a chain-like structure, linked to glycerol. (There are also mono- and di-glycerides, which have one and two fatty acid chains, respectively, attached to glycerol.)

Like many other things necessary to life, fat is a two-edged sword. Fat insulates us from the cold, cushions and protects our vital organs and serves as a storehouse for energy. Yet, when present in excess to the point of obesity, fat threatens health, happiness, self-esteem, social standing and longevity. The same is true of other lipids, most notably triglycerides and cholesterol. Transported throughout the body in the bloodstream, these essential lipids become a health liability when the blood contains too much of them.

Keeping fat in it its proper place, not eliminating or drastically reducing it, is the goal we should seek. In the blood, lipids must be maintained at healthy levels and ratios. When they are, an important foundation of good health is established.

How do we keep the blood lipids we need——triglycerides and the various forms of cholesterol——balanced at healthy levels? Diet and exercise are indispensable, these basics must come first. Along with the recommended dietary practices, a number of nutritional approaches offer help for maintaining healthy blood lipids. We will now give several of these a closer look.

Gugulipid

In 1990, an herb used for centuries in the Far East was introduced to U.S. consumers. This herb, called "gum guggul," is proving to be one of the most effective natural cholesterol-lowering agents ever discovered. It also brings triglycerides down and raises HDL, the "good" cholesterol. The changes are substantial; gum guggul single-handedly normalizes the entire blood lipid profile, even in people with high starting levels of cholesterol and triglycerides.

Gum guggul, also called simply "guggul," is a gummy resin tapped from the Commiphora tree. A cousin of myrrh gum, guggul has been used by Ayurvedic herbalists of India for at least 3,000 years; texts dating from around 1,000 B.C. mention the herb. Guggul was traditionally given for rheumatism and poor health caused by excess consumption of fatty foods. One ancient Sanskrit text describes in detail what happens in the body when blood fats are out of balance, due to sedentary lifestyle and overeating. The name of this condition has been translated as "coating and obstruction of channels."

Intrigued by the obvious similarity between "coating and obstruction of channels" and arteries clogged by fatty plaque, Indian researchers initiated a series of experimental and clinical studies in the 1960's to see if gum guggul would lower excess blood lipids.1 Both human and animal studies consistently showed cholesterol and triglyceride reductions.

Detailed pharmacological studies showed that guggul's lipid-lowering effects are produced by compounds in the resin called "guggulsterones."2 An Indian pharmaceutical firm then patented a standardized extract of gum guggul under the trade name "Gugulipid." The product contains a uniform 2.5 percent guggulsterones, which is higher than guggul resin in its natural state.

Because Gugulipid guarantees the necessary intake of guggulsterones needed for blood fat reduction, it has become the product used in clinical research. PHASE I efficacy safety trials and PHASE II efficacy trials have yielded more positive data.3,4,5 Most of the studies on gum guggul have used relatively small numbers of subjects; this tends to make mainstream medical scientists reluctant about natural remedies. A large, well-publicized double-blind Gugulipid trial on 400 to 500 people would go a long way toward giving this herb the credibility it deserves.

Pantethine

Another effective natural solution for blood fat control that should be better known is a relative of pantothenic acid (vitamin B5). Pantethine is the active form of pantothenic acid in the body. Pantethine forms CoA, an essential co-enzyme for utilization of fat. CoA transports "active acetate," an important byproduct of fat metabolism that provides fuel for generating cellular energy. By promoting the burning of fats for energy, pantethine helps keep triglyceride levels down.6 Pantethine also helps regulate cholesterol production, by facilitating the conversion of fat into other lipid-based molecules needed in the body.6

Japanese researchers began studying the effect of pantethine on blood fats nearly twenty years ago. They reported their promising results at the Seventh International Symposium on Drugs Affecting Lipid Metabolism, held in Milan, Italy in 1980.7 Few in the medical or scientific communities took notice. Italian researchers followed up with several small clinical trials that confirmed the preliminary reports.6,8,9 An excellent cholesterol and triglyceride lowering agent that is safe and free of side-effects, pantethine remains, for the most part, ignored by mainstream science, although its usage is growing in alternative medicine circles. Pantethine it will no doubt prove to be one of the most important supplements for maintaining healthy blood fat levels.

Niacin

When taken in high enough doses, niacin (vitamin B3) substantially lowers cholesterol. This has been known to medical science for many years.10 studies on niacin as a cholesterol-lowering agent go back to the 1950's. There was a fair amount of initial enthusiasm for niacin because it improves, unlike most lipid-lowering drugs, all parameters of the blood lipid profile. Niacin reduces total cholesterol, LDL cholesterol and triglycerides. It also raises HDL cholesterol quite well. Interest in niacin has faded, in part because the necessary dose, 1200 milligrams a day or more, can cause flushing and gastrointestinal disturbances. Very high doses may be harmful to the liver if taken for too long.

There is a solution to the side-effect problem with niacin which, again, has failed to gain widespread attention. Inositol hexanicotinate is a flush-free form of niacin composed of six niacin molecules bonded to one molecule of inositol, another B-complex nutrient. Absorbed as an intact structure, inositol hexanicotinate is metabolized slowly, releasing free niacin into the bloodstream over a period of hours following ingestion.11 Inositol hexanicotinate has all the benefits of niacin for controlling blood fats. The flushing effect of ordinary niacin, which metabolizes much more rapidly, does not occur. Taking as much as four grams per day has not been reported to raise liver enzymes or cause other side-effects, but prudence dictates that people with liver problems should avoid very high doses of inositol hexanicotinate, or any form of niacin.12

Tocotrienols

We often think of vitamin E as synonymous with d-alpha tocopherol. Vitamin E is actually a whole family of compounds that includes various tocopherols and a group of lesser known but highly beneficial substances called "tocotrienols." All have vitamin E activity. Tocotrienols are similar in chemical structure to tocopherols, but they have important differences which give them unique and highly beneficial properties for human health.

Vitamin E is one of the most recognized antioxidants, nutrients that deactivate potentially toxic byproducts of oxygen metabolism known as free radicals. Vitamin E neutralizes peroxides, which result from the free radical oxidation of lipids, making it a key antioxidant in cell membranes. While d-alpha tocopherol has generally been regarded as the form of vitamin E with the strongest antioxidant activity, tocotrienols are even stronger.

The tocotrienol story is another example of a natural product slow to gain recognition. A Univeristy of California research team discovered that d-alpha tocotrienol is over six times more effective than d-alpha tocopherol at protecting cell membranes against free radical damage.13 In the presence of vitamin C, which recycles vitamin E-like compounds, its antioxidant activity is 40 to 60 times higher than d-alpha tocopherol. This study was published in 1991. Its safe to say few cardiac physicians know about tocotrienols, and we have yet to see 60 Minutes do a piece on "the powerful new form of vitamin E."

It would be a tremendous service to public health if they did, because the benefits of tocotrienols go far beyond their stellar antioxidant ability. Tocotrienols also lower total cholesterol and LDL, by impressive percentages. In one double-blind controlled study, tocotrienols reduced total cholesterol by 16 percent and LDL by 21 percent after twelve weeks. Another study recorded drops of 15 to 22 percent in total cholesterol along with 10 to 20 percent decreases in LDL levels.14 Now appearing on health food store shelves, tocotrienols are a health-protecting nutrients whose long overdue time has come. Derived from food oils such as palm oil and rice bran oil, tocotrienols have the same lack of toxicity as ordinary vitamin E.

References

1. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.

2. Dev, S. A modern look at an age-old Ayurvedic drug—guggulu. Science Age July 1987:13-18.

3. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.

4. Agarwal, R.C. et. al. Clinical trial of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.

5. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.

6. Maggi, G.C., Donati, C., Criscuoli, G. Pantethine: A physiological lipomodulating agent, in the treatment of hyperlipidemias. Current Therapeutic Research 1982;32(3):380-86.

7. Kimura, S., Furukawa, Y., Wakasugi, J. Effects of pantethine on the serum lipoprotiens in rats fed a high cholesterol diet (Abstract) Seventh International Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1980.

8. Arsenio, L. Bodria, P. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clinical Therapeutics 1986;8(5):537-45.

9. Avogaro, P. Bittolo Bon, G. Fusello, M. Effect of pantethine on lipids, lipoproteins and apolipoproteins in man. Current Therapeutic Research 1983;33(3):488-93.

10. Crouse, J.R. New developments in the use of niacin for treatment of hyperlipidemia: new considerations in the use of an old drug. Coronary Artery Disease 1996;7(4):321-26.

11. Welsh, A.L. Ede, M. Inositol hexanicotinate for improved nicotinic acid therapy. International Record of Food Medicine 1961;174(1):9-15.

12. "Inositol hexaniacinate" (Monograph). Alternative Medicine Review 1998;3(3):222-3.

13. Serbinova, E., et. al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha tocotrienol. Free Radical Biology and Medicine 1991;10:263-275.

14. Qureshi, N. Qureshi, A.A. Tocotrienols: Novel Hypercholesterolemic Agents with Antioxidant Properties. in 'Vitamin E in Health and Disease' Lester Packer and Jürgen Fuchs, Editors. 1993; New York: Marcel Dekker, Inc.

Control Cholesterol with the following Supplements

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VitaNet®
VitaNet ® Staff

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Date: May 09, 2005 06:10 PM
Author: Darrell Miller (dm@vitanetonline.com)

It's in the Blood

The National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen.

“The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks.

“Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).”

At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke.

While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!”

Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.”

And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.”

Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.”

King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.”

Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.

"Blur of Products"

With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.”

To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following:

Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent.

Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels.

Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.”

“The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.”

On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone.

Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients.

Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs.

Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic.

Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action.

Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.”

Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take.

“Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels.

Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids.

Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period.

“The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake.

For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.”

Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients.

Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO.

Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols.

Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol.

Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky.

“In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.”

Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.”

Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said.

However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.”

Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.”

Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up PHASE III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols.

Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”

New Weapons

There are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise.

With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.”

Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM.

“Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR

Vitamin Retailer Magazine, Inc., 431 Cranbury Road, East Brunswick, NJ 08816 //www.oprmagazine.com/

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