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Relieve muscle spasms naturally with the pomegranate
October 12, 2018 07:52 AM
Research shows that pomegranate can reduce muscle spasms which also allows it to be treated for spasm related conditions including diarrhea. The rind of a pomegranate has chemicals which relieve muscle spasms, but research is still being done as to a safe dosage of this chemical. Other home remedies that can reduce muscle spasms include water, electrolytes, tea, massages and rest. If the situation is more severe, you should go visit a health professional immediately.
"Past research has confirmed the spasmolytic properties – the ability to reduce or cease spasms – of pomegranate rind, but the exact mechanism was not made clear."
Read more: https://www.naturalnews.com/2018-09-28-relieve-muscle-spasms-naturally-with-the-pomegranate.html
August 28, 2009 01:50 PM
Jojoba is a shrub that is native to the Sonoran and Majoave desserts of Arizona, California, and Mexico. It is the only species in the family SImmondsiaceae. Sometimes, it is also placed in the box family, Buxaceae. This herb is also known as goat nut, deer nut, pignut, wild hazel, quinine nut, coffeeberry, and gray box bush. The jojoba plant grows one to two meters tall and has a broad, dense crown. The leaves are opposite, oval in shape, and approximately two to four centimeters in length and 1.5 to 3 centimeters wide. The leaves are thick, waxy, and gray-green in color. The flowers are small and greenish-yellow in color. They have five to six sepals and no petals. Each plant is neither male or female. Hermaphrodites in this species are extremely rare. The fruit of the jojoba plant is an acorn-shaped ovoid that is one to two centimeters long. The mature seed is a hard oval, dark brown in color, and contains about fifty-four percent oil.
Jojoba foliage gives a year-round food opportunity for many animals. Among these include deer, jaelina, bighorn sheep, and livestock. The nuts are often eaten by squirrels, Rabbits, other rodents, and larger birds. The only animal known to be able to digest the wax that is found inside the jojoba nut is the Bailey’s Pocket Mouse. The seed meal is toxic to many mammals when taken in large quantities. The indigestible wax often acts as a laxative in humans.
Native Americans in Arizona, California, and northern Mexico used jojoba for the hair and as a tonic for the body. The herb is a valuable crop for some Native American tribes in those areas. This herb can be found in shampoos, conditioners, moisturizers, and sunscreens.
Jojoba oil, which is made from the seeds of the plant, has been used traditionally by Native Americans. They use this herb to promote hair growth and relieve skin problems. Jojoba helps to remove the sebum deposits that are responsible for causing dandruff and scalp disorders. This herb is responsible for making the scalp less acidic.
One study found the wax that is in the jojoba oil to treat acne and psoriasis. This herb has traditionally been used successfully for this purpose. In addition, it is used to heal minor skin irritations. A study on Rabbits found that those who were fed jojoba oil had a reduction of forty percent in their blood cholesterol levels. The reason or component that is responsible for this activity still remains unknown.
The oil of the jojoba plant is used to provide emollient properties. The primary nutrients found in jojoba are chromium, copper, iodine, silicon, vitamins E and B complex, and zinc. It is important to consult your health care provider before consider using this or any other supplement while on prescription medications. Primarily, jojoba is very beneficial in treating dandruff, hair loss, psoriasis, and dry scalp.
Additionally, this herb is extremely helpful in dealing with abrasions, acne vulgaris, athlete’s foot, cuts, eczema, pimples, seborrhea, mouth sores, warts, and wrinkles. For more information on the many benefits provided by jojoba, please feel free to contact a representative from your local health food store with questions.
August 10, 2009 12:52 PM
The Cherokee tribe used scullcap as an emmenagogue. It was also used historically as an anti-convulsant. An Asian scullcap has been used by Chinese physicians as a tranquilizer, sedative, and to treat convulsion. The herb was used in the eighteenth century as a treatment for rabies by some physicians. Later, it was recommended by eclectic physicians for insomnia, nervousness, malaria, and convulsions. The herb was officially listed in the U.S. Pharmacopoeia from 1863 to 1916. It was also found in the National Formulary from 1916 to 1947.
This herb is responsible for treating a variety of conditions. Among these include pain, anxiety, high blood pressure, and epilepsy. scullcap is well known for its ability to calm the nerves and also to help with all nervous system conditions. Additionally, it has been used to treat infertility, fatigue, inflamed tissues, digestion, coughs, and headaches. Some herbalists consider scullcap to be one of the best nervine herbs that is available. It has been used as a nerve tonic. It also can promote a feeling of well-being and promote relaxed sleep. Some people recommend scullcap for problems that are associated with drug and alcohol withdrawal, as it may lessen the severity of the symptoms. Traditional uses of this herb have included infertility, regulation of sexual desire, and as a remedy for cramps and pain.
Research one in both Europe and Russia has proven the benefits of scullcap as a tranquilizer as well as a mild sedative. The herb is recommended for use in nervous conditions in order to induce sleep and relaxation. Some evidence has shown that Asian scullcap contains component which inhibit the enzyme sialidase. This enzyme is known to increase in certain disease states like cancer, infections, and inflammations. Another study done in vitro found an antibacterial and antifungal activity in scullcap. Some early evidence has also been found of scullcap’s ability to treat high blood pressure. The herb is used and prescribed widely in Europe. Studies using animals in Japan showed that scullcap has the ability to increase the levels of good cholesterol and prevent serum cholesterol levels from rising. This study was done on Rabbits, as they were fed a high-cholesterol diet. These findings suggest that scullcap may also act as a heart disease and stroke preventive.
The entire scullcap herb is used to provide alterative, analgesic, antibacterial, antifungal, antispasmodic, febrifuge, nervine, and sedative properties. The primary nutrients found in this herb are calcium, iron, magnesium, potassium, vitamins C and E, and zinc. Primarily, scullcap is extremely beneficial in treating anxiety, high blood pressure, convulsions, epilepsy, infertility, insomnia, nerve problems, and restlessness.
Additionally, this herb is very helpful in dealing with alcoholism, poisonous bites, childhood diseases, chorea, poor circulation, coughing, delirium, drug withdrawal, fevers, hangover, headaches, hydrophobia, hypertension, hypoglycemia, insanity, neuralgia, pain, palsy, Parkinson’s disease, rabies, rheumatism, rickets, spasms, spinal meningitis, thyroid problems, tremors, and urinary problems. In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by scullcap, please feel free to consult a representative from your local health food store with questions.
July 28, 2009 11:32 AM
Saffron was used by the Greeks and Chinese as a royal dye because of its yellow color. Wealthy Romans used this herb to perfume their homes. In Europe, it was used medicinally between the fourth and eighteenth centuries. It was also being used in the kitchen to cook with.
In the book The Complete Herbal, Nicholas Culpeper recommended using saffron for the heart, brain, and lungs. The herb was also suggested for acute diseases like smallpox and measles. It was also recommended for hysteric depression. Dr. David Culbreth characterized the herb as a pain reliever and was said to promote perspiration and gas explosion and ease painful menstruation in the book Materia Medica and Pharmacology. Saffron was also said to relieve eye infections and encourage sore eruptions.
This herb is soothing to both the stomach and colon. It is responsible for acting as a blood purifier. Saffron helps stimulate circulation and regulate the spleen, heart, and liver. It is also helpful in reducing inflammation; treating arthritis, gout, bursitis, kidney stones, hypoglycemia, and chest congestion; improving circulation; and promoting energy. Small doses should be taken internally for coughs, gas, and colic and to stimulate appetite. The herb can also be applied externally in a salve for gout.
It has been shown that saffron may even help to reduce cholesterol levels. It neutralizes uric acid buildup in the system. Recent research determined that Rabbits, which were fed crocetin, which is a component of saffron, had a significant reduction in cholesterol and triglyceride levels. Saffron is eaten daily in Valencia and Spain, resulting in little heart disease occurring among inhabitants. The evidence has shown that saffron increases oxygen diffusion from the red blood cells. Not only does it discourage uric acid buildup, it also inhibits the accumulation of lactic acid. Therefore, it may help prevent heart disease.
Other research done on saffron suggests that the crocetin ingredient may have the potential to act as an anticancer agent in studies done both in vitro and in animals. On study that was done using saffron extract in vitro found that tumor colony cell growth was limited by inhibiting the cellular nucleic acid synthesis. Additional research on cancer has found that saffron that was given orally helped in increasing the life span of mice with variety of laboratory-induced cancers.
The flowers of the saffron plant are used to provide alterative, anodyne, antineoplastic, antispasmodic, aphrodisiac, blood purifier, carminative, diaphoretic, emmenagogue, expectorant, sedative, and stimulant. The primary nutrients found in this herb are calcium, lactic acid, phosphorus, potassium, sodium, and vitamins A and B12. Primarily, saffron is extremely beneficial in treating fevers, gout, indigestion, liver disorders, measles, excessive perspiration, phlegm, psoriasis, rheumatism, scarlet fever, and stomach acid. Additionally, this herb is very helpful in dealing with appetite loss, arthritis, blood impurities, bronchitis, cancer, colds, conjunctivitis, coughs, fatigue, gas, headaches, heartburn, uterine hemorrhages, hyperglycemia, hypoglycemia, insomnia, jaundice, kidney stones, menstrual symptoms, skin disease, tuberculosis, ulcers, water retention, and whooping cough.
In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by saffron, please feel free to consult a representative from your local health food store with questions. Saffron is available at your local or internet health food store. Note: Saffron should not be consumed internally.
Butterbur Extract Fact Sheet
December 08, 2005 04:22 PM
Butterbur Extract Fact SheetNeil E. Levin, CCN, DANLA 8/1/05
LIKELY USERS: People wanting to support healthy blood flow to the brain and healthy neurological function 1-6,10 Those maintaining normal seasonal immune responses 7-10
KEY INGREDIENTS: 75 mg of Guaranteed Potency Butterbur Root (Petasites hybridus) Extract, min. 15 Sesquiterpenes as Petasines; 200 mg of Feverfew Leaf (Tanacetum parthenium) min. 0.4% Parthenolides
MAIN PRODUCT FEATURES: Butterbur (Petasites hybridus) is a native shrub of Europe, North America, and Asia that has been used by herbalists for centuries. Modern scientific studies have demonstrated that Butterbur supports healthy blood flow to the brain and healthy neurological function.1-6, 10 In addition, Butterbur may help to maintain balanced seasonal immune responses.7-10 In a synergistic base of guaranteed potency Feverfew leaf.11-26
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW Butterbur is free of harmful levels of Pyrrolizidine Alkaloids (PAs), the undesirable compounds naturally found in Butterbur, so it is safe to use regularly.
SERVING SIZE & HOW TO TAKE IT: Take one VCap one to three times per day, or as directed by your physician.
COMPLEMENTARY PRODUCTS: Magnesium, Ulcetrol, B-2, B-12, Fish Oil (EPA, DHA), SAM-e, Ginger, Ginkgo Biloba
SPECIFIC: Do not discontinue use abruptly; taper off use if discontinuing. Discontinue use at least 14 days before surgery or oral surgery. Use with caution if you have ragweed allergies or blood disorders and let your physician know that you plan to use it before you take it. May be contraindicated for pregnant women.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Diener HC, Rahlfs VW, Danesch U (2004) The First Placebo-Controlled Trial of a Special Butterbur Root Exract for the Preventio of Migraine: Reanalysis of Efficacy Criteria. Eur Neurol 51:89-97.
Allibiotic CF Fact Sheet
December 07, 2005 01:37 PM
Allibiotic CF Fact SheetNeil E. Levin, CCN, DANLA 03/09/05
LIKELY USERS: People seeking support of the immune system and intestinal flora
KEY INGREDIENTS: Allicin (“AlliSure” patented, stabilized allicin from fresh garlic); Olive Leaf Extract (Olea Europaea with 18% minimum Oleuropein content); Elderberry extract, from fruit/berry, 60:1 concentrate (equivalent to 2,500 mg. of fresh berries of Sambucus nigra); Oil of Oregano (wild oregano from Origanum vulgare) ImmunEnhancer AG (trademarked Arabinogalactan from Larch Tree, Larix occidentalis)
MAIN PRODUCT FEATURES: AlliSure is the clinically tested, patented and stable form of allicin. Not allicin potential, but actual allicin. Allicin represents the immune supporting nutrients of raw garlic, and is chemically similar to penicillin, though with different physical properties. AlliSure shares garlic’s abilities to help maintain healthy cholesterol and blood pressure levels, and also has been shown to raise levels of a key T cell to enhance immune system function. Like raw garlic, AlliSure has antimicrobial properties linked to its ability to react with sulfur-containing metabolic enzymes. Allicin is also shown in studies to play a role in controlling blood sugar and abnormal cell growth.
Black Elderberries have strong antioxidant properties, containing flavonoids like anthocyanidins. They have been studied in relation to inhibition of viral replication and of minor inflammations.
Olive Leaf has been used as an antioxidant, cholesterol and blood viscosity regulator, and vasodilator. But its most important use has been as a way to help the body deal with undesirable organisms in the vital respiratory and intestinal areas.
Oil of Oregano (wild oregano, wild marjoram) contains carvacrol and thymol, which are responsible for much of its antimicrobial activities. It also has some anti-inflammatory effects.
Arabinogalactan from Larch tree bark (ImmunEnhancer AG) can help speed the immune system’s response to undesirable organisms and is often compared to Echinacea. It has also been shown to promote the growth of beneficial intestinal bacteria.
ADDITIONAL PRODUCT INFORMATION: Patented and trademarked ingredients enhance quality controls and have clinical research. Rosemary Oil provides antioxidant protection for the capsule contents. Enteric coating protects the capsule from stomach acid to deliver its contents past the stomach. This helps to assure full potency and reduces the possibility of the oils repeating.
SERVING SIZE & HOW TO TAKE IT: One softgel twice daily, preferably with meals. Try one before using the full dose.
COMPLEMENTARY PRODUCTS: Probiotics, Antioxidants, D-Flame
CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Discontinue use if any uncomfortable side effects occur. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001 Jul-Aug;18(4):189-93. (AlliSure was used in this study.)
Abramovitz D, Gavri S, Harats D, Levkovitz H, Mirelman D, Miron T, Eilat-Adar S, Rabinkov A, Wilchek M, Eldar M, Vered Z. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis. 1999 Oct;10(7):515-9. PMID: 10562920
Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother. 1997 Oct;41(10):2286-8. PMID: 9333064
Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol. 1996 Apr;13(4):273-7. PMID: 8739190
Chowdhury AK, Ahsan M, Islam SN, Ahmed ZU. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in Rabbits. Indian J Med Res. 1991 Jan;93:33-6.
Eilat S, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z. Alteration of lipid profile in hyperlipidemic Rabbits by allicin, an active constituent of garlic. Coron Artery Dis. 1995 Dec;6(12):985-90. PMID: 8723021
Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Oron-Herman M, Rosenthal T. The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens. 2003 Dec;16(12):1053-6. PMID: 14643581
Feldberg RS, Chang SC, Kotik AN, Nadler M, Neuwirth Z, Sundstrom DC, Thompson NH. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrob Agents Chemother. 1988 Dec;32(12):1763-8.
Focke M, Feld A, Lichtenthaler K. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS Lett. 1990 Feb 12;261(1):106-8.
Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer. 2000;38(2):245-54. PMID: 11525603
Patya M, Zahalka MA, Vanichkin A, Rabinkov A, Miron T, Mirelman D, Wilchek M, Lander HM, Novogrodsky A. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol. 2004 Feb;16(2):275-81. PMID: 14734613
Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):144-153. PMID: 11118647
Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1998 Feb 2;1379(2):233-44. PMID: 9528659
Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004 Apr;111(4):391-9. PMID: 15056375
Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N. Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24. PMID: 15044429
Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med. 1985 Oct;(5):460-1. PMID: 3001801
Uchida Y, Takahashi T, Sato N. [The characteristics of the antibacterial activity of garlic (author's transl)] Jpn J Antibiot. 1975 Aug;28(4):638-42. PMID: 1099271
Yasuo Yamada and Keizô Azuma. Evaluation of the In Vitro Antifungal Activity of Allicin. Antimicrob Agents Chemother. 1977 April; 11(4): 743–749.
Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 423.
Gruenwald J, Brendler T, Jaenicke C, et al. (eds). PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 1998, 1116–7.
Mascolo N, Autore G, Capasso G, et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res 1987;1:28–31.
Murkovic M, Abuja PM, Bergmann AR, et al. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study. Eur J Clin Nutr. Feb2004;58(2):244-9.
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 104–5.
Yesilada E. Inhibitory Effects of Turkish Folk Remedies on Inflammatory Cytokines: Interleukin-1Alpha, Interleukin-1Beta and Tumor Necrosis Factor Alpha. J Ethnopharmacol. Sept1997;58(1):59-73. Youdim KA, Martin A, Joseph JA. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radical Biol Med 2000;29:51–60.
Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Alt Compl Med 1995;1:361–9.
OLIVE LEAF EXTRACT:
American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.
Bennani-Kabchi N, et al. Effects of Olea europea var. oleaster leaves in hypercholesterolemic insulin-resistant sand rats. Therapie. Nov1999;54(6):717-23.
Bisignano G, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. Aug1999;51(8):971-4. Gonzalez M, et al. Hypoglycemic activity of olive leaf. Planta Medica. 1992;58:513-515. Visoli F, et al. Oleuropein protects low density lipoprotein from oxidation. Life Sciences. 1994;55:1965-71. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:557.
Petroni A, et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.Thromb Res. Apr1995;78(2):151-60. Pieroni A, et al. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie. Oct1996;51(10):765-8. Zarzuelo A, et al. Vasodilator effect of olive leaf. Planta Med. Oct1991;57(5):417-9. OREGANO OIL (OIL OF OREGANO, WILD OREGANO, WILD MARJORAM):
Dorman HJ, et al. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. Feb2000;88(2):308-16. Force M, et al. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. May2000;14(3):213-4.
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985–90.
Kelm MA, Nair MG, Strasburg GM. Antioxidant and Cyclooxygenase Inhibitory Phenolic Compounds from Ocimum sanctum Linn. Phytomedicine. Mar2000;7(1):7-13. Lamaison JL, et al. Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm Acta Helv. 1991;66(7):185-8.
Ponce MM, Navarro AI, Martinez GMN, et al. In vitro effect against Giardia of 14 plant extracts. Rev Invest Clin 1994;46:343–7 [in Spanish].
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Tantaoui EA, Beraoud L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ Pathol Toxicol Oncol 1994;13:67–72. ImmunEnhancer AG (Larch tree Arabinogalactan)
Corado J, et al. Impairment of Natural Killer (NK) Cytotoxic Activity in Hepatitis C Virus (HCV) Infection. Exp Immunol. 1997;109:451-457. Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53. PMID: 12725568
Egert D, et al. Studies on Antigen Specificity of Immunoreactive Arabinogalactan Proteins Extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58:163-165. Gonda R, et al. Arabinogalactan Core Structure and Immunological Activities of Ukonan C, An Acidic Polysaccharide from the Rhizome of Curcuma longa. Biol Pharm Bull. 1993;16:235-238. Hagmar B, et al. Arabinogalactan Blockade of Experimental Metastases to Liver by Murine Hepatoma. Invasion Metastasis. 1991;11:348-355. Kelly GS. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev. 1999 Apr;4(2):96-103. Review. PMID: 10231609
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Levine PH, et al. Dysfunction of Natural Killer Activity in a Family With Chronic Fatigue Syndrome. Clin Immunol Immunopathol. 1998;88:96-104. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-85. PMID: 11506055
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Uchida A. Therapy of Chronic Fatigue Syndrome. Nippon Rinsho. 1992;50:2679-2683.
Astragalus Fact Sheet
December 07, 2005 01:15 PM
Astragalus Fact SheetNeil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy
KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg)
MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides.
ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!).
SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach.
COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants.
CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
Immune Renew Fact Sheet
December 07, 2005 01:07 PM
Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans
KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)
MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.
ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels
SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.
COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.
This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
Best Mangosteen 10% Extract with xanthone flavonoids
July 27, 2005 11:31 AM
• Defends Against Free Radicals*
The xanthone flavonoids and other compounds in mangosteen fruit are responsible for its high level of antioxidant activity. In vitro tests have been conducted on XanoMax? mangosteen 10% extract to determine the level of free radical scavenging ability in both watery and fatty environments. A major test recognized as the industry standard for measuring antioxidant activity is known as the ORAC (Oxygen Radical Absorbance Capacity) assay.
The ORAC test is an in vitro assay that works by measuring the amount of free radical damage done to a fluorescent probe (measured by a change in probe intensity). Antioxidants lessen the damage to the probe fluorescence, which indicates a reduction in free radical damage. This measure is used to quantify the antioxidant’s (or combination of antioxidants) capacity to quench free radicals. This quantification is known as the total ORAC value. The total ORAC value provides a relative measure of total antioxidant strength of any substance, allowing for comparison of different mixtures. A high ORAC value corresponds to a high total in vitro antioxidant capacity.
The development of the ORAC test has led to a number of commonly eaten foods being assessed in terms of total ORAC scores per serving. Similarly, particular combinations of antioxidants, such as those in nutritional formulas, can also be assessed for their total ORAC scores. This has led to the ability to determine the potential usefulness of a particular supplement in increasing overall antioxidant capacity.
When XanoMax? mangosteen 10% extract was tested for ORAC value, the resulting antioxidant potential was over 3,500 ORAC units per gram of extract. This result is extremely high. ORAC values of compounds vary with their nutrient concentration, moisture content and other factors. For comparison purposes, whole blueberries, considered to be a rich source of antioxidants, had an ORAC value of 61 units per gram, while pomegranate tested at 105 ORAC units per gram.1 XanoMax? mangosteen extract is a potentially rich source of beneficial antioxidants*
• Maintains Healthy Immune Function*
Evidence from several animal and in vitro studies on various cell lines suggests that components of mangosteen fruit extract may play a role in modulating several factors important to healthy immune function. Of the active components, xanthone derivatives seem to play the major role in influencing parameters of immune function in animals and in vitro models. Mangostin is the xanthone derivative that most of these studies have focused on.
A study published in 2002 assessed the effects of mangosteen extracts on the release of histamine from rat cell lines. The comparison was made to extracts of a plant frequently used in Japan, Rubus suavissimus, which is a known inhibitor of IgE-mediated histamine release from these cells. The assay showed that the mangosteen extracts used inhibited the release of histamine from these cells more potently than the extract of Rubus suavissimus. In addition, the authors compared the two herbs for prostaglandin E2 synthesis in another rat cell line and found that the mangosteen extract potently inhibited prostaglandin E2 synthesis in this in vitro trial, whereas the other herb had no effect.2
An earlier study was performed in guinea pig tracheal and Rabbit thoracic aortal tissue. In this study, alpha mangostin prevented histamine-induced contraction and was shown to be a competitive histamine receptor antagonist in the smooth muscle tissue of the trachea and aorta of the animals selected. The results seen in this laboratory study were determined to be concentration-dependent. The authors suggested that alpha mangostin should undergo further studies to determine its effects on the modulation of the histamine response.3
Further in vitro assessments point to potential actions of mangosteen components in modulating effectors of occasional inflammation in the immune system. Studies in rat glioma cells suggest that mangostins inhibit enzymatic reactions that can lead to the production of specific prostaglandins.4,5 By inhibiting these reactions, mangostins may play a role in modulating overall immune function, promoting healthy immunity.
Mangosteen and its constituents hold much promise for their potential ability to enhance immune function and promote health. In addition to being a highly nutritious food, mangosteen extract is full of antioxidant activity. It has an extremely high ORAC value and a great potential for enhancing free radical defenses in the body. Best Mangosteen 10% extract contains XanoMax ™, which is standardized to a high level of active mangostin, the class of compounds shown in in vitro studies to benefit certain aspects of immune function. Safety Scientific References
Quercetin and Bromelain - for better health.
July 04, 2005 10:28 AM
Down-regulates the Body’s Response to Environmental Challenges Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids. Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein.1 Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist.1 Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action.2 Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability.3 Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells.4 A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils.5,6,7,8,9,10
Quercetin modifies the body’s response to antigenic substances.* Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing granules in mast cells.3 Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges.
Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the release of arachidonic acid from phospholipids stored in cell membranes.4,10 Arachidonic acid serves as the key substrate for substances such as thromboxanes, inflammatory prostaglandins and leukotrienes. In addition, quercetin inhibits the enzymes cyclooxygenase and lipoxygenase, which catalyze the conversion of arachidonic acid into its metabolites.4,10,11,12 Reducing levels of these metabolites, as well as histamine levels, is beneficial in maintaining the normal comfort level of body tissues and structures.
Quercetin has also been shown to limit the function of adhesion molecules on endothelial cells.13 Adhesion molecules are involved in physiologic processes that influence tissue comfort.13
Bromelain is a complex substance derived from the pineapple stem largely composed of proteolytic (protein-digesting) enzymes. Bromelain acts by a variety of mechanisms to help maintain tissues in a normal state of comfort.14,15 Several investigators, including Taussig16 and Ako, et. al.,17 have presented evidence that bromelain is a fibrinolytic agent, i.e., it induces the breakdown of fibrin, a plasma protein that blocks tissue drainage. The generally accepted mechanisms involve direct proteolysis of fibrin by bromelain and activation of plasmin, a serum protease.16 Plasmin acts on fibrinogen (the precursor to fibrin), forming peptides which stimulate PGE1, a prostaglandin that helps maintain tissue comfort.16
Helps Maintain Health of Blood Vessels by Modifying Oxidation of LDL Cholesterol* — Quercetin’s Antioxidant Action Quercetin is a versatile and effective antioxidant that scavenges a variety of free-radicals such as hydroxyl and lipid peroxy radicals.18 Quercetin also chelates ions of transition metals such as iron, which can initiate formation of oxygen free radicals.18 LDL cholesterol is vulnerable to oxidation by lipid peroxides. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, leading to the formation of “foam cells,” and eventually plaque deposits, in arterial walls. Quercetin has been shown to protect LDL from oxidation, both by lipid peroxides and transition metal ions.19
Quercetin inhibits blood platelet aggregation (clumping), by potentiating PGI2, an anti-aggregatory prostaglandin, and by raising platelet cyclic AMP levels.20 Human studies have revealed that bromelain also reduces platelet aggregation.21 These properties qualify both quercetin and bromelain as valuable dietary ingredients for maintaining cardiovascular health.*
In addition to the actions described above that support the effects of quercetin, bromelain may also assist the absorption of quercetin in the G.I. tract. (Quercetin is generally believed to be poorly absorbed, although a recent study by Hollman et. al.,22 which concluded that humans do in fact absorb appreciable amounts of quercetin, contradicts this assumption.) Studies have shown that bromelain enhances absorption of antibiotics, presumably by increasing permeability of the gut wall.23, 24 Given that quercetin is a low molecular-weight compound, it is plausible that simultaneously ingested bromelain likewise enhances quercetin absorption.
June 25, 2005 08:13 PM
1 a. The Surgeon General’s “Nutrition and Health Report.” b. The Centers for Disease Control and Prevention’s “National Health and Examination Survey (NHANES III)” c. The National Academy of Science’s. Diet and Health Report: Health Promotion and Disease Objectives (DHHS Publication No. (PHS) 91-50213, Washington, DC: US Government Printing Office, 1990). e. Dietary Guidelines for Americans. 2 Rolls BJ. Carbohydrates, fats, and satiety. Am J Clin Nutr 1995; 61(4 Suppl):960S-967S. 3 McDowell MA, Briefel RR, Alaimo K, et al. Energy and macronutrient intakes of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1:1988-91. Advance data from vital and health statistics of the Centers for Disease Control and Prevention; No. 255. Hyattsville, Maryland: National Center for Health Statistics; 1994. 4 Center for Science in the Public Interest and McDonald’s Nutrition and You—A guide to Healthy Eating at McDonald’s: McDonald’s Corp,1991. 5 Bray GA. Appetite Control in Adults. In: Fernstrom JD, Miller GD eds. Appetite and Body Weight Regulation. Boca Raton: CRC Press, 1994:1-92. 6 Michnovicz JJ. How to Reduce Your Risk of Breast Cancer. New York: Warner Book Inc. 1994:54. 7 Carcinogens and Anticarcinogens in the Human Diet. National Research Council Report, National Academy of Sciences, 15 Feb. 1996. 8 Van Tallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979:32: 2723-33. 9 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:273. 10 Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16A-hydroxyestrone to estradiol in human breast concer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1988:85;7831-5. 11 Colditz GA. Epidemiology of breast cancer. Findings from the nurses’ health study. Cancer1993;714:1480-9. 12 Hennen WJ. Breast Cancer Risk Reduction. The effects of supplementation with dietary indoles. Unpublished report 1992. 13 Deslypere BJ. Obesity and cancer. Metabolism 1995;44(93):24-7. 14 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:281. 15 Whittemore AS, Kolonel LN, John M. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 1995;87(9):629-31. 16 Key T. Risk factors for prostate cancer. Cancer Survivor 1995;23:63- 77. 17 Kondo Y, Homma Y, Aso Y, Kakizoe T. Promotional effects of twogeneration exposure to a high-fat diet on prostate carcinogenisis in ACI/Seg mice. Cancer Res 1994;54(23):6129-32. 18 Wang Y, Corr JG, Taler HT, Tao Y, Fair WR, Heston WD. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst. 1995;87(19):1456-62. 19 Nixon DW. Cancer prevention clinical trials. In-Vivo 1994;8(5):713-6. 20 Key T. Micronutrients and cancer aetiology: the epidmiological evidence. Proceed Nutr Soc 1994;53(3):605-14. 21 Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Reviews of Infectious Diseases 1990;12(Suppl 2):S252-61. 22 Shrapnel WS, Calvert GD, Nestel PJ, Truswell AS. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Australia. 1995;156(Suppl):S9-S16. 23 Ellis JL, Campos-Outcalt D. Cardiovascular disease risk factors in native Americans: a literature review. Am. J. Preventive Med 1994;10(5):295-307. 24 DiBianco R. The changing syndrome of heart failure: an annotated review as we approach the 21st century. J. Hypertension 1994; 12(4 Suppl):S73- S87. 25 Van Itallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979;32(suppl):2723-33. 26 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure and glucose metabolism in mildly hyper-cholesterolemic men. Am J Clin Nutr 1990;52(4):661-6. 27 Story JA. Dietary fiber and lipid metabolism. In: Spiller GA, Kay RM. eds. Medical Aspects of Dietary Fiber. Penun Medical; New York, 1980, p.138. 28 Stein PP, Black HR. The role of diet in the genesis and treatment of hypertension. Med. Clin. North America. 1993;77(4):831-47. 29 Olin JW. Antihypertensive treatment in patients with peripheral vascular disease. Cleve. Clin. J. Medicine. 1994;61(5):337-44. 30 Tinker LF. Diabetes Mellitus—a priority health care issue for women. J. Am. Dietetic Association. 1994;94(9):976-85. 31 Gaspard UJ, Gottal JM, van den Brule FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas. 1995;21(3):71-8. 32 Coordt MC, Ruhe RC, McDonald RB. Aging and insulin secretion. Proc. Soc. Exp. Biology and Medicine. 1995;209(3):213-22. 33 Felber JP. From Obesity to Diabetes. Pathophysiological Considerations. Int. Journal of Obesity 1992;16:937-952. 34 Gillum RF. The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women age 18-79. J Chronic Diseases 1987;40:421-8. 35 Haffner SM, Stern MP, Hazuda HP, et al. Role of obesity and fat distribution in non-insulin-dependent diabetes mellits in Mexican Americans and non- Hispanic whites. Diabetes Care 1986;9:153-61. 36 Bonadonna RC, deFronzo RA. Glucose metabolism in obesity and type 2 diabetes. Diabetes and Metabolism. 1991;17(1 Pt. 2):12-35. 37 Shoemaker JK, Bonen A. Vascular actions of insulin in health and disease. Canadian J. of Applied Physiology. 1995;20(2):127-54. 38 Resnick LM. Ionic Basis of Hypertension, Insulin Resistaince, Vascular Disease, and Related Disorders. The Mechanism of ‘Syndrome X’. Am. J. Hypertension. 1993;6(suppl):123S-134S. 39 Trautwein EA. Dietetic influences on the formation and prevention of cholesterol gallstones. Z. Ernahrugswiss. 1994;33(1):2-15. 40 Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs and Aging. 1995;6(5):409-20. 41 Melnyk MG, Wienstein E. Preventing obesity in black women by targeting adolescents: a literature review. J Am. Diet. Association. 1994;94(4):536-40. 42 Robinson BE, Gjerdingen Dk, Houge DR. Obesity: a move from traditional to more patient-oriented management. J. Am. Board of Family Practice. 1995;8(2):99-108. 43 Dulloo AG, Miller DS. Reversal of Obesity in the Genetically Obese fa/fa Zucker Rat with an Ehpedrine/Methylxanthines Thermogenic Mixture. J. Nutrition. 1987;117:383-9. 44 Dulloo AG, Miller DS. The thermogenic properties of ephedrin/methylxanthine mixtures: animal studies. Am J Clinical Nutr. 1986;43:388-394. 45 Richelsen B. Health risks of obesity. Significance of the regional distri-bution of adipose tissue. Ugeskr. Laeger. 1991;153(13):908-13. 46 Lissner L, Heitmann BL. Dietary fat and obesity: Evidence from epidemiology. European J. Clinical Nutrition. 1995;49(2):79-90. 47 Lissner L, Heitmann BL. The dietary fat: Carbohydrate ratio in relation to body weight, Current Opinion in Lipidology. 1995;6(1):8-13. 48 Ravussin E. Energy metabolism in obesity. Studies in the Pima Indians. Diabetes Care. 1993;16(1):232-8. 49 O’Dea K. Westernisation, insulin resistance and diabetes in Australian aborigines. Med J. Australia. 1991;155(4):258-64. 50 Bailey C. Fit or Fat . Houghton Mifflen, Boston, 1991. 51 McCarty MF. Optimizing Exercise for Fat Loss. Unpublished report. 52 Weinsier RL, Schutz Y, Bracco D. Reexamination of the relationship of resting metabolic rate and fat-free mass and the the metabolically active components of fat-free mass in humans. Am. J. Clinical Nutrition. 1992;55(4):790-4. 53 Evans WJ. Exercise, nutrition and aging. J. Nutrition. 1992;122(3 suppl):796-801. 54 Schlicker SA, Borra ST, Regan C. The weight and fitness status of United States children. Nutrition Reviews. 1994;52(1):11-7. 55 Raben A, Jensen ND, Marckmann P, Sandstrom B and Astrup A. Spontaeous weight loss during 11 weeks’ ad libitum intake of a low fat/high fiber diet in young, normal weight subjects. Stockholm Press. 1995;916-23. 56 Blundell JE, Cotton JR, Delargy H, Green S, Greenough A, King NA, Lawton, CL. The fat paradox: fat-induced satiety signals versus high fat overconsumption. Short Communication 1995:832-835. 57 Reinhold RB. Late results of gastric bypass surgery for morbid obesity. J Am Coll Nutr 1994;13(4):307-8. 58 McCredie M, Coates M Grulich A. Cancer incidence in migrants to New South Wales (Australia) from the Middle East, 1972-1991. Cancer Causes Control 1994:5(5):414-21. 59 Schiff ER, Dietschy JM. Steatorrhea Associated with Disordered Bile Acid Metabolism. Am. J. Digestive Diseases. 1969;14(6) 60 Nauss JL , Thompson JL and Nagyvary J. The binding of micellar lipids to Chitosan. Lipids. 1983;18(10):714-19. 61 Braconnot H, Sue la natrue ces champignons. Ann Chim Phys 1811;79:265. 62 Odier A. Memoire sur la composition chemique des parties cornees des insectes. Mem Soc Hist Nat Paris 1823;1:29. 63 Johnson EL, Peniston QP. Utilization of shellfish waste for chitin and Chitosan production. Chp 19 In: Chemistry and Biochemistry of Marine Food Products. Martin RE, Flick GJ, Hebard CE and Ward DR (eds.) 1982. p.415-. AVI Publishing Co., Westport, CT. 64 Shahram H. Seafood waste: the potential for industrial use. Kem Kemi 1992;19(3),256-8. 65 Rouget C. Des substances amylacees dans le tissue des animux, specialement les Articules (Chitine). Compt Rend 1859;48:792. Commission on Natural Health Products. 1995 67 Peniston QP and Johnson EL. Method for Treating an Aqueous Medium with Chitosan and Derivatives of Chitin to Remove an Impurity. US Patent 3,533,940. Oct. 30:1970. 68 Poly-D-Glucosamine (Chitosan); Exemption from the Requirement of a Tolerance. Federal Register. 1995;60(75):19523-4. Rules and Regulations. Environmental Protection Agency 40 CFR Part 180. April, 19, 1995. 69 Arul J. “Use of Chitosan films to retard post-harvest spoilage of fruits and vegetables,” Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 70 Karlsen J, Skaugrud O. “Excipient properties of Chitosan,” Manufacturing Chemist. 1991;62:18-9. 71 Winterowd JG, Sandford PA. Chitin and Chitosan. In: Food Polysaccharides and their Applications. Ed: Stephen AM. Marcel Dekker 1995. 72 Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 73 Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 74 Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 75 Zikakis, JP. Chitin, Chitosan and Related Enzymes. Academic Press, Inc. 1984. 76 Abelin J and Lassus A. Fat binder as a weight reducer in patients with moderate obesity. ARS Medicina, Helsinki, Aug- October, 1994. 77 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Increasing effect of a Chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58(9):1617-20. 78 Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of Chitosan in adult males. Biosci Biotchnol Biochem1993;57(9):1439-44. 79 Kobayashi T, Otsuka S, Yugari Y. Effect of Chitosan on serum and liver cholesterol levels in cholesterol-fed rats. Nutritional Rep. Int., 1979;19(3):327-34. 80 Sugano M, Fujikawa T, Hiratsuji Y, Hasegawa Y. Hypocholesterolemic effects of Chitosan in cholesterol-fed rats. Nutr Rep. Int. 1978;18(5):531-7. 81 Vahouny G, Satchanandam S, Cassidy M, Lightfoot F, Furda I. Comparative effects of Chitosan and cholestryramine on lymphatic absorption of lipids in the rat. Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in Rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.
GINSENG and the Reproductive System
June 25, 2005 01:07 PM
There has been a lot of interest in the reported aphrodisiac effects of ginseng. It is often marketed as a sexual stimulant. Yet the results of most studies have been i n c o n c l u s i ve. Asian ginseng seemed to increase the sperm count in Rabbits as well as the egg laying of hens in some studies. A Korean study found the mating behavior of rats to increase with ginseng consumption.36 Hormonal secretions are thought to be stimulated by ginseng which may be one reason for its use as an aphrodisiac. 37 Ginseng has also been found to influence the growth of the testes and testosterone levels.38 Studies on Siberian ginseng have found its tonic effect to help with sexual function. It was found to increase the sperm count in animals.39 Ginseng has been used for thousands of years to strengthen the male reproductive system. Clinical studies and historical use seems to support the claims of ginseng use for the reproductive system. It is highly recommended alone or in combinations for male and female health. However, it is generally not recommended that women take it over long periods of time.
BLOOD SUGAR AND GARLIC
June 25, 2005 10:18 AM
BLOOD SUGAR AND GARLIC
The allicin compounds of garlic have been found to possess a significant blood sugar lowering action. Clinical studies have suggested that these compounds lower glucose levels by competing with insulin sites in the liver which results in an increase of free insulin.43 Research has found that animals and humans with diabetes experienced a decline in blood sugar while taking garlic. Interestingly, if blood sugar is normal, the garlic did not promote this lowering effect.
Several animal and human studies have shown that garlic may be a very valuable therapeutic agent for diabetes. Diabetics routinely struggle with high blood sugar readings. Studies in India conducted by medical doctors revealed that garlic is one of the few completely natural and harmless substances which is effective in the treatment of diabetes. Onion and garlic juice were given to Rabbits who had been turned into artificial diabetics. Immediately, their blood sugar levels decreased. Some diabetics who find it difficult to stabilize their blood sugars with insulin injections, may want to experiment with garlic.
Apparently, some of the sulfur-containing compounds of garlic have special sugar metabolism regulating capabilities. As mentioned earlier, these factors are desireable in cases of both low and high blood sugar disorders.
INFECTIONS AND GARLIC
June 25, 2005 10:12 AM
INFECTIONS AND GARLIC
With the advent of modern antibiotic drugs, garlic lost its status as an effective infection fighter. Unfortunately, Garlic’s past track record was diminished by the arrival of new and potent antibiotics like penicillin. Ironically, several years ago, garlic was reported to be more valuable than penicillin when treating throat infections.26
One reason for this may be that the allicin component of garlic is effective against the streptococci bacteria. Traditional Oriental medicine utilized garlic in a variety of forms to treat all kinds of infections: garlic juice for typhoid, and meningitis, garlic vapors for whooping cough, garlic suppositories for yeast infections and garlic soup for pneumonia.27 According to studies in the Journal of the National Medical Association, Garlic has proved its ability to act as a potent antibiotic against various gram-negative, gram-positive and acid fast bacteria.
In view of the fact that garlic has even been shown to be effective against some antibiotic-resistent organisms, it should be utilized more in standard medical treatments. Several medical practitioners have discovered that like throat infections, ear infections also respond nicely to garlic. The great advantage of using garlic over antibiotics is that Garlic will not kill friendly intestinal bacteria or make one more susceptible to future infections. Antibiotics will. In cases where antibiotics are deemed necessary, they should at the very least be supplemented with garlic.
Current research supports the fact that garlic does indeed inhibit bacterial growth.28 Several strains of Mycobacterium are suppressed by the presence of garlic. For anyone who fights chronic bladder infections, garlic may prove invaluable. It has been shown to inhibit the growth of several organisms associated with urinary tract infections.29
Evidence suggests that garlic can effectively treat bacterial ear infections, sore throats, and infected wounds. Several reports have shown that aged garlic extract is particularly effective for the kind of ear infections that children are prone to develop. (Note: Ingesting raw garlic is not a practical way to utilize its allicin compounds as an effective antibiotic. Too much raw garlic would be required to be effective.)
It is common knowledge that as of now, viruses do not respond to antibiotics and are extremely resistent to other forms of treatment. A virus usually has to run its course, as those of us who suffer periodically from colds and flu know all too well. Because viruses are so hardy, it is important to know that garlic possesses antiviral as well as antibacterial properties. Dr. Andrew Weil M.D. states that the best home remedy he has found for the treatment of colds is to eat several cloves of raw garlic at the first indication that a cold is developing.30 Several laboratory tests have shown that garlic is an effectual treatment for both the influenza B virus and herpes simplex virus.31
Two independent researchers in Japan and Romania have found that garlic is able to protect living organisms form the influenza virus.32 Chinese scientists have studies the effect of garlic on viral encephalitis for almost 30 years.
Clarissa McCord of Cloverdale, British Columbia used garlic extract to treat a stubborn virus that attacks horses. She relates:
“A bottle of liquid garlic administered on two successive days to each animal does the job of curing. One of my race hors es developed the virus symptoms and was to be scratched from the racing program scheduled for the following day. I gave one bottle of liquid garlic to the animal and he improved sufficiently to enter the race. He hit the board first, second and third.”33
In relation to human beings, it would seem that Garlic is especially effective in cases of influenza as both a treatment to shorten the duration of the disease and as a preventative. Again, garlic’s ability to stimulate the immune system seems intrinsically linked to its anti-viral action. Whether the infection is bacterial or viral, garlic mobilizes immune function, thereby potentiating the body’s ability to defend itself against infectious organisms.
Garlic in certain forms is considered a potent antibiotic and can be particularly effective against certain fungal infections. Like viruses, fungal infections are particularly difficult to treat . Traditional medical treatments for fungal infections are usually toxic and can be ineffectual over the long term. To the contrary, garlic has proven itself as an effective anti-fungal agent against candida, aspergillus and cryptococci.
A report from a Chinese medical journal delineates the use of intravenous garlic to treat a potentially fatal and rare fungal infection of the brain called cryptococcal meningitis. In the report, the Chinese compared the effectiveness of the garlic with standard medical treatment which involved a very toxic antibiotic called Amphotericin-B. The study revealed that intravenous garlic was more effective than the drug and was not toxic regardless of its dosage.34
One study using liquid garlic extract found that candida colonies were substantially reduced in mice that had been treated with the garlic. This same study also revealed that garlic stimulated phagocytic activity. This implies that infections such as candida may be controlled because garlic stimulates the body’s own defenses. Applied externally, garlic oil can be used to treat ringworm, skin parasites and warts. Lesions that were caused by skin fungi in Rabbits and guinea pigs were treated with external applications of garlic extract and began to heal after seven days.35
Allicin is primarily a fungistatic substance which can slow or completely stop the proliferation of the microorganisms. As an external treatment, garlic has also been found to effectively treat acne and thrush.
HIGH BLOOD PRESSURE AND GARLIC THERAPY
June 25, 2005 10:01 AM
HIGH BLOOD PRESSURE AND GARLIC THERAPY
Garlic has been used for generations in China and Japan for as a traditional medicine for hypertension. Even today, it continues to be a popular remedy for a disease that has become an epidemic in the western world. Taking a daily dose of garlic can result in a 12 to 30 mmHg reduction is systolic blood pressure and a 7 to 20 mmHg reduction in diastolic pressure in people who suffer from essential hypertension.12
One scientific study revealed that 40 out of 100 patients with high blood pressure experienced a reduction of 20 mmHg or more after a week of garlic treatment.13 Apparently, Rabbits and humans who have been tested with garlic have demonstrated a rapid and continued decrease in blood pressure. One reason for this is that garlic seems to dilate blood vessel walls.14 It is the methyl allyl trisulfide contained in garlic which creates this action. Evidently, the effectiveness of using garlic for high blood pressure is dependent to some extent on the type of garlic used. Bulgarian studies suggested that aged Garlic extracts were more effective although this view has been subject to debate. Most practitioners who use garlic for their hypertensive patients recommended a high dosages initially.
In 1992, an article in Planta Medica, a German scientific journal, suggested that gamma-glutamyl-S-allyl-cysteine, a peptide found in Garlic, inhibits a certain enzyme which is involved in the conversion of certain hormones that actually regulate blood pressure. Angiotensin I does not raise blood pressure, however, Angiotensin II can. The peptide found in garlic inhibited the enzyme that changes Angiotensin I into Angiotensin II.15 Consequently, blood pressure levels dropped.
In addition to the actions discussed above, the ajoene compounds in garlic also help to prevent high blood pressure by inhibiting the tendency of blood cells to adhere together and create clots. Garlic oil can increase the breakdown of fibrin by over 100 percent in humans.16 When the blood is discouraged from clotting, blood flow is not restricted, therefore, blood pressure does not rise. Some people who have been on hypertensive drugs have gradually been able to wean themselves off using garlic. If you decide to use garlic for high blood pressure, make sure you check with your doctor and do not abruptly stop taking your medication. (Note: People who have abnormally low blood pressure need not avoid eating garlic. There is evidence to suggest that hypotension benefits from the therapeutic effects of garlic as well as hypertension.
Considering these findings, it would seem that garlic acts to normalize blood pressure whether it be high or low, an action which prescription drugs cannot accomplish.)
GARLIC AND CARDIOVASCULAR HEALTH
June 25, 2005 09:59 AM
GARLIC AND CARDIOVASCULAR HEALTH
Recent research has supported the fact that garlic shows excellent potential in the treatment of cardiovascular diseases. Disorders of the heart and the circulatory system claim more lives than any other disease. It is the obstruction or clogging of the coronary arteries which causes more deaths that any other factor. The arteries, which supply the heart with blood and oxygen, become increasingly narrower as plaque builds up over time. When blood supply becomes so restricted that a certain portion of the heart is deprived of oxygen, a heart attack occurs.
The two greatest predictors of heart disease are high blood pressure and high blood serum cholesterol levels. Both of these determinants are directly impacted by the therapeutic action of Garlic. What is particularly relevant about the role of Garlic in coronary heart disease is that several studies done on Rabbits found that even pre-existing atherosclerotic deposits and lesions could actually be reversed if garlic was consistently consumed.4
Granted, the above study has not been performed on humans, however, its implications are extremely significant. It is important to remember that it is not always what we are eating that causes heart disease, but what we are not eating. Studies like the one just described suggest that even if our diets were high in cholesterol, adding chemical compounds like the ones found in garlic may keep us from developing cardiovascular disease. This might explain why some cultural groups which consume high fat diets do not suffer the coronary consequences so typical of our population.
What is particularly exciting about the potential of garlic for anyone suffering from heart disease is that it can help reverse the disease and substantially reduce the risk of a second heart attack. The longer garlic is used, the better its results are. For example; people who have heart disease showed more improvement after the third year of garlic therapy than before. A possible explanation for this is that using garlic consistently over time progressively reverses hardening of the arteries, therefore the longer the garlic usage, the less the risk of heart attack.5 The New York Times ran an article on garlic in their September 4, 1990 edition. Concerning heart disease and garlic, it stated:
“...most exciting to those attending the conference, which was co-sponsored by Pennsylvania State and the Federal Department of Agriculture, were the results of a three year study in India among 432 coronary patients who had already suffered one heart attack. The patients were randomly divid ed into two groups, with one group receiving daily supple ments of garlic juice in milk. Those who took the garlic sup plements suffered fewer additional heart attacks, had lower blood pressure and serum cholesterol levels and were less likely to die during the study. After three years, nearly twice as many patients had died in the group not taking garlic . . . Patients who drank the garlic supplement were more likely to report such subjective benefits as an increase in vigor, energy and sexual desire, improvements in exercise tolerance, and a decrease in joint pains and asthmatic tendencies.”
June 22, 2005 09:57 PM
CLA and Ather osclerosis
June 22, 2005 09:47 PM
CLA and Ather osclerosis
CLA may well have benefits in the battle against heart disease as well. The leading cause of death in the United States is heart disease or related diseases of the circulatory system. Indeed, U.S. statistics show that about half the people in the United States die that way.
In 1989, for example, some 2 million Americans died, and about 950,000 of those died as a direct or indirect result of heart disease. T h a t’s far more than the total number of deaths fro m AIDS, shootings, bombings and accidents combined.3 4 For pers p e c t i ve, let’s discuss what happens when a new s w o rthy accident o c c u r s — l e t’s say an airline crash that kills 200 people.
Statistically speaking, five times that many people will die the same day of heart disease, as many as two each minute. Thankfully, doctors have made great progress in battling these conditions, and researchers have discovered that a healthy lifestyle can help the heart. Indeed, as almost everyone knows, balanced nutrition, lower stress and plenty of exercise can lead a person to be more healthy and to run a lower risk of heart attack and other heart conditions. Evidently, at least in animals, CLA seems to possess the ability to cut risks as well. Dr. Pariza and two colleagues, Kisun Lee and David Kritchevsky, studied a group of 12 Rabbits that were fed a diet high in fat and cholesterol. They gave six of them CLA. In the academic journal Atherosclerosis, they reported that two dangerous compounds, LDL cholesterol and triglycerides, were “markedly lower” in the six that had diets supplemented with CLA.
When the scientists looked at the aortas—the largest artery leading from the heart—of these animals, they also found a lot less blockage than in those that didn’t have CLA. This is how they summarized their results: “CLA appears to be hypocholesterolemic and anti-atherogenic.”35 This is pretty bold stuff for cautious scientists. Though the words are complex, the statement is clear: CLA seems to cut cholesterol and makes it so veins won’t clog as easily. This finding was surprising to Dr. Pariza. Science shows that straightened fatty acids (trans-fatty acids) of which CLA is one, usually tend to increase the risk of heart disease. Pariza said it only made sense to test CLA with this kind of science. Indeed, the best he would hope for would be no effect.36 In 1996, another group studied atherosclerosis and hamsters supplementing diets with CLA. CLA didn’t cut the amount of cholesterol in the blood within three months, but it did cut the amount of fatty build-up in the aorta of the hamsters.37 The bottom line on heart disease and CLA? Because two different types of animals show less clogging of the arteries, it seems clear that a good chance exists for the same thing to happen in humans. Of course, as with the cancer research, solid studies in humans need to be conducted for researchers to say definitely that this can cut your risk of heart disease. But until that day, the news is good: A nutritional regimen that includes solid antioxidants like vitamin C and vitamin A, that includes magnesium,38 coenzyme Q10,39 and that includes other important circulatory system-fortifiers would likely benefit from CLA. Couple that nutrition with a healthful lifestyle, and your chances of living longer and living better will likely increase.
Policosanol and cholesterol control ...
May 17, 2005 06:25 PM
In addition, after 30 days of therapy, 20 and 40 mg/day policosanol significantly ( P < 0.01) reduced low-density lipoprotein– cholesterol (15.9 and 17.0%, respectively) and total cholesterol (12.4 and 12.3%, respectively; P < 0.05), yet increased high-density lipoprotein–cholesterol values by 5% in both groups ( P < 0.05).
Policosanol is a mixture of higher aliphatic primary alcohols purified from sugar cane ( Saccharum officinarum L) 4,5 wax, the main component of which is octacosanol, followed by triacontanol and hexacosanol; other alcohols (tetracosanol, heptacosanol, nonacosanol, dotriacontanol and tetratriacontanol) are minor components. The cholesterol-lowering effects of policosanol have been proven in healthy volunteers, 6,7 patients with type II hypercholesterolaemia 8–25 and in dyslipidaemia due to type II diabetes mellitus. 26,27
The hypocholesterolaemic effect of policosanol is associated with inhibition of cholesterol biosynthesis at a step located between acetate consumption and mevalonate production, although inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase has been discarded. 28–30 Policosanol also increases low-density lipoprotein (LDL) receptor-dependent processing in fibroblast cultures, 28 as well as the clearance of [ 125 I]-labelled LDL–cholesterol (LDL-C) administered to Rabbits with hypercholesterolaemia induced by a cholesterol-free casein-rich diet. 29
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Guggul – New Benefits for Heart Health
May 11, 2005 09:00 PM
Gum Guggul–New Benefits for Heart Health from an Age-Old Herbby Richard Conant, L.Ac., C.N.
The 1990's have seen a growing interest in herbs from India's ancient Ayurvedic tradition. One Ayurvedic herb in particular, "gum guggul," stands at the forefront, thanks to its rather remarkable benefits for the heart and cardiovascular health. A relative of myrrh and frankincense, gum guggul is a resin tapped from India's Commiphora mukul tree. Known more commonly in the Far East as simply "guggul," the herb has proven to be one of the most effective natural cholesterol-lowering agents ever discovered. Cholesterol reductions with guggul can be twenty percent or higher, and the herb also raises HDL, the more beneficial form of cholesterol. Studies also show guggul may help prevent atherosclerosis, by retarding the formation of fatty, cholesterol-laden deposits in blood vessel tissues.
Recent research on guggul has revealed that guggul also blocks the oxidation of LDL cholesterol, by acting as an antioxidant. LDL, which carries cholesterol from the liver to the rest of the body, is generally regarded as a key element in the development of atherosclerosis. But only when it is oxidized by free radicals does LDL accumulate in arteries. It its unoxidized or "native" state, LDL is more or less benign. Checking LDL oxidation is vital to keeping blood vessels free of plaque.1 (This is one of the major reasons why antioxidants are so important.) Guggul, by both lowering blood cholesterol and acting against LDL oxidation, now stands out as one of the world's most valuable herbs for heart health.
Guggul first caught the attention of the scientific world in1966, thanks to an Indian medical researcher who submitted a doctoral thesis on gum guggul.2 Her interest had been kindled by references to the herb in a centuries-old Ayurvedic text. Apparently, poor cardiovascular health and atherosclerosis were a problem back then just as they are today. Translated from Sanskrit, this text describes, in elegant detail, a condition called "coating and obstruction of channels." The cause, according to the ancient writers? Faulty metabolism due to overeating of fatty foods and lack of exercise. Death was said to be the end result of leaving this condition uncorrected. The recommended treatment plan emphasized diet and herbs, chiefly gum guggul.3
References to guggul in ancient literature actually go back even farther. The herb is mentioned in the Vedas, the holy scriptures of India believed to be anywhere from 3,000 to 10,000 years old. One stanza is translated as follows: "Disease (consumption) does not afflict and the curse never affects whom the delicious odor of the healing Guggul penetrates (spreads). The diseases also flee away in all directions from him like horses and deer, O Gugulu! Either born from Sindhu or from the sea. I chant your name for the removal of diseases."3
Struck by the obvious similarity between "coating and obstruction of channels" and atherosclerosis, the Indian researcher decided to study gum guggul's effect on blood fats in Rabbits. Over a two-year period, the animals were fed hydrogenated vegetable oil to artificially raise their cholesterol levels. Guggul was administered to one group of Rabbits, while the rest served as controls. At the end of the study the Rabbits given guggul had normal cholesterol and blood lipid levels. Their arteries showed no fatty streaks or plague deposits. This caught the attention of the Indian scientific community, and numerous clinical trials ensued, both on animals and humans. In study after study, guggul consistently produced substantial reductions in cholesterol and triglyceride levels, while raising HDL.
The active ingredients in guggul are a group of natural plant sterols. Among these, substances called "guggulsterones" are the most important ingredients for the cholesterol and blood fat lowering properties of guggul, with the other sterols acting as a synergistic supporting cast.4 A number of mechanisms are suggested, although not definitely proven, for how the herb works; these include reducing the synthesis of cholesterol in the liver, enhancing cholesterol removal from the gut, stimulating thyroid function and increasing the number of receptors in the liver for uptake of LDL.3,5
Guggul extracts are now standardized for guggulsterone content. The herb naturally contains about 2 percent guggulsterones. Quality extracts contain a minimum of 2.5 percent, which assures the user is getting a product potent enough to produce results. Since the late 1980's clinical trials have used the standardized extract.6,7,8 The product is readily available in the U.S.
The ability of guggulsterones to prevent oxidation of LDL was discovered in a 1997 study done by scientists at the Central Drug Research Institute in Lucknow, India.9 This study sheds light on how guggul works against "coating and obstruction of channels." Remember that oxidized LDL forms the plaque that coats and eventually obstructs blood vessels. The researchers mixed LDL from human blood with a free radical promoting agent, either alone or in combination with guggulsterones. Samples were then analyzed for the presence LDL oxidation byproducts. The results showed that guggulsterones strongly protect LDL from being oxidized. Guggulsterones block the formation of hydroxyl radicals, a potent type of free-radical that attacks cell membranes.
Guggulsterones may also help keep the heart muscle itself healthy. When the heart muscle is deprived of oxygen, a condition known as "myocardial ischemia," it can be severely damaged by free radicals. The body tries to counter this with SOD, a key enzyme present in cells that neutralizes free radicals. SOD levels are significantly reduced in damaged heart tissues. Guggulsterones have been found to reverse this decrease by more than two-fold.10
Like the writer of that age-old verse found in the Vedas, contemporary herbalists hold gum guggul in the highest regard. Backed as it is by scientific research linked to centuries of traditional use, gum guggul has a bright future as a natural resource for maintaining normal cholesterol and blood fats, and for protecting heart health.
1. Heinecke, J.W. Free radical modification of low density lipoprotein: mechanisms and biological consequences. Free Radical Biology & Medicine 1987;3:65-73.
2. Satyavati, G.V. Effect of an indigenous drug on disorders of lipid metabolism with special reference to atherosclerosis and obesity (Medoroga) M.D. thesis (Doctor of Ayurvedic Medicine). Banaras Hindu University, varanasi, 1966.
3. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.
4. Dev, S. A modern look at an age-old Ayurvedic drug-guggulu. Science Age July 1987:13-18.
5. Singh, V. et. al. Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats. Pharmacological Research 1990;22(1):37-44.
6. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.
7. Agarwal, R.C. et. al. Clinical trial of gugulipid-a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.
8. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.
9. Singh, K., Chandler, R. Kapoor, N.K. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytotherapy Research 1997;11:291-94.
10. Kaul, S. Kapoor, N.K. Reversal of chnages of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats. Indian Journal of Experimental Biology 1989;27:625-627.
Red Yeast Rice can Lower Cholesterol. Scientific Studies prooven
May 09, 2005 11:33 AM
Department of Biochemical Pharmacology, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100083, China.
Long-term effects of Cholestin (Monascus purpureus rice; red yeast rice) on serum lipids and severity of atherosclerosis were examined in Rabbits fed for 200 days on a semi-purified diet containing 0.25% cholesterol. Serum total cholesterol was 25 and 40% lower, respectively, in Rabbits fed 0.4 or 1.35 g/kg/day of Cholestin (Monascus purpureus rice; red yeast rice) compared to controls. This treatment also lowered serum LDL cholesterol. This 200-day treatment significantly reduced serum triglycerides and atherosclerotic index (ratio of non-HDL-cholesterol to HDL-cholesterol). Although similar reductions of total, LDL-cholesterol and triglycerides were observed, a parallel group of Rabbits fed lovastatin (0.0024 g/kg/day) failed to reduce the index significantly. Apolipoprotein A(1) was increased and apolipoprotein B was reduced in all treatment groups. Severity of atherosclerosis was reduced significantly in all treatment groups. The sudanophilic area of involvement was 80.6% in controls, and reduced significantly; to 30.1% on the low dose (Monascus purpureus rice; red yeast rice), and 17.2% on the high dose. Lovastatin reduced severity of lesions by 89% (sudanophilia) and 84% (visual). Visual grading of lesion severity showed reduction by 38% and 68%.
PMID: 12873712 [PubMed - indexed for MEDLINE]